RGD Reference Report - Possible implications of MCAM expression in metastasis and non-metastatic of primary uveal melanoma patients. - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources

Possible implications of MCAM expression in metastasis and non-metastatic of primary uveal melanoma patients.

Authors: Beutel, J  Wegner, J  Wegner, R  Ziemssen, F  Nassar, K  Rohrbach, JM  Hilgers, RD  Luke, M  Grisanti, S 
Citation: Beutel J, etal., Curr Eye Res. 2009 Nov;34(11):1004-9. doi: 10.3109/02713680903262205.
RGD ID: 7364775
Pubmed: PMID:19958117   (View Abstract at PubMed)
DOI: DOI:10.3109/02713680903262205   (Journal Full-text)

PURPOSE: To evaluate the expression of melanoma cell adhesion molecule (MCAM) as prognostic factor in uveal melanoma patients. METHODS: Paraffin sections from 35 primary uveal melanomas were analyzed immunhistochemically for the expression of MCAM. Further known prognostic factors such as cell type, ciliary body invasion, tumor stage, and local extension were evaluated. In 16 cases, patients had developed metastatic disease. The patients without metastasis (n = 19) had a mean follow-up of 10.6 (9-13) years. RESULTS: All tumors were positive for MCAM (mean: 57.05%). In the group without metastasis, an average MCAM expression of 35.37% (SD 19.66%) compared to 82.78% (SD 11.73%) in the metastasis group was found. The Cox regression analysis showed a significant association of an enhanced MCAM expression and death due to metastasis (HR: 365.48, 95% CI: 18.51, 7217.85). CONCLUSION: MCAM expression of primary uveal melanomas can serve as a possible prognostic parameter for metastasis. If further experiments approve the cellular adhesion molecules to account for early micrometastasis of tumor cells, a possible target might be available for future treatment.



RGD Manual Disease Annotations    Click to see Annotation Detail View
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
MCAMHumanuveal melanoma disease_progressionIEP  RGD 
McamRatuveal melanoma disease_progressionISOMCAM (Homo sapiens) RGD 
McamMouseuveal melanoma disease_progressionISOMCAM (Homo sapiens) RGD 

Objects Annotated

Genes (Rattus norvegicus)
Mcam  (melanoma cell adhesion molecule)

Genes (Mus musculus)
Mcam  (melanoma cell adhesion molecule)

Genes (Homo sapiens)
MCAM  (melanoma cell adhesion molecule)


Additional Information