Slfn4 (schlafen family member 4) - Rat Genome Database

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Pathways
Gene: Slfn4 (schlafen family member 4) Rattus norvegicus
Analyze
Symbol: Slfn4 (Ensembl: Slfn4l1)
Name: schlafen family member 4 (Ensembl:schlafen family member 4 like 1)
RGD ID: 620455
Description: Predicted to enable RNA nuclease activity and ribosome binding activity. Involved in lung alveolus development. Predicted to be located in cytosol and nucleus. Orthologous to several human genes including SLFN12 (schlafen family member 12); INTERACTS WITH 17alpha-ethynylestradiol; 17beta-estradiol; 17beta-estradiol 3-benzoate.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Cdk107; LOC102553282; schlafen 3; schlafen 4; Slfn3; uncharacterized LOC102553282
RGD Orthologs
Human
Mouse
Bonobo
Dog
Green Monkey
Alliance Orthologs
More Info more info ...
Candidate Gene For: Bp312
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81068,492,135 - 68,515,674 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1068,508,916 - 68,513,991 (+)EnsemblGRCr8
mRatBN7.21067,994,601 - 68,018,141 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1067,994,632 - 68,018,138 (+)EnsemblmRatBN7.2
mRatBN7.2 Ensembl1068,000,028 - 68,018,138 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1072,614,701 - 72,638,151 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01072,120,085 - 72,143,535 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01067,584,123 - 67,607,575 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01070,411,686 - 70,435,162 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1070,411,738 - 70,435,156 (+)Ensemblrn6Rnor6.0
Rnor_5.01070,045,721 - 70,069,233 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41071,277,765 - 71,301,183 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1066,943,545 - 66,961,594 (+)NCBICelera
RGSC_v3.11071,291,014 - 71,314,467 (+)NCBI
Cytogenetic Map10q26NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytosol  (ISO)
nucleus  (ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Gene expression profiling in lung fibroblasts reveals new players in alveolarization. Boucherat O, etal., Physiol Genomics. 2007 Dec 19;32(1):128-41. Epub 2007 Oct 2.
2. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
3. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
5. Schlafen, a new family of growth regulatory genes that affect thymocyte development. Schwarz DA, etal., Immunity 1998 Nov;9(5):657-68.
6. Human T-cell leukemia virus type 1 Tax protein stimulates the interferon-responsive enhancer element via NF-kappaB activity. Shimizu T, etal., FEBS Lett 2003 Mar 27;539(1-3):73-7.
Additional References at PubMed
PMID:19228883   PMID:19703412   PMID:19996332   PMID:20299602   PMID:21596996   PMID:22906252   PMID:23012479   PMID:24089532   PMID:24244554  


Genomics

Comparative Map Data
Slfn4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81068,492,135 - 68,515,674 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1068,508,916 - 68,513,991 (+)EnsemblGRCr8
mRatBN7.21067,994,601 - 68,018,141 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1067,994,632 - 68,018,138 (+)EnsemblmRatBN7.2
mRatBN7.2 Ensembl1068,000,028 - 68,018,138 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1072,614,701 - 72,638,151 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01072,120,085 - 72,143,535 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01067,584,123 - 67,607,575 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01070,411,686 - 70,435,162 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1070,411,738 - 70,435,156 (+)Ensemblrn6Rnor6.0
Rnor_5.01070,045,721 - 70,069,233 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41071,277,765 - 71,301,183 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1066,943,545 - 66,961,594 (+)NCBICelera
RGSC_v3.11071,291,014 - 71,314,467 (+)NCBI
Cytogenetic Map10q26NCBI
SLFN12
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381735,410,922 - 35,433,174 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1735,409,347 - 35,433,475 (-)Ensemblhg38GRCh38
GRCh371733,737,941 - 33,760,193 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361730,762,192 - 30,783,656 (-)NCBIBuild 36Build 36hg18NCBI36
Celera1730,648,230 - 30,669,690 (-)NCBICelera
Cytogenetic Map17q12NCBI
HuRef1729,923,102 - 29,944,498 (-)NCBIHuRef
CHM1_11733,802,400 - 33,823,865 (-)NCBICHM1_1
T2T-CHM13v2.01736,351,811 - 36,381,711 (-)NCBIT2T-CHM13v2.0
Slfn4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391183,066,001 - 83,081,042 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1183,066,012 - 83,081,042 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm381183,175,172 - 83,190,216 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1183,175,186 - 83,190,216 (+)Ensemblmm10GRCm38
MGSCv371182,988,688 - 83,003,718 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361182,991,381 - 83,006,411 (+)NCBIMGSCv36mm8
Celera1192,764,702 - 92,779,735 (+)NCBICelera
Cytogenetic Map11CNCBI
cM Map1150.3NCBI
SLFN12
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21929,039,285 - 29,068,736 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11730,920,265 - 30,949,716 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01721,359,252 - 21,384,308 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11721,652,566 - 21,676,326 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1721,652,566 - 21,676,326 (+)EnsemblpanPan2panpan1.1
SLFN12
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1938,140,071 - 38,146,347 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha937,363,941 - 37,370,841 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0938,951,413 - 38,958,375 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
UMICH_Zoey_3.1937,735,395 - 37,742,344 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0938,020,063 - 38,027,019 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0938,107,811 - 38,114,775 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
SLFN12
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11628,883,628 - 28,913,393 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1628,883,886 - 28,912,880 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_0236660751,067,844 - 1,099,183 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0

Variants

.
Variants in Slfn4
169 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:177
Count of miRNA genes:137
Interacting mature miRNAs:160
Transcripts:ENSRNOT00000055955, ENSRNOT00000071656, ENSRNOT00000072281
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1549846Scl47Serum cholesterol level QTL 473.6blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)105107189796071897Rat
152025229Scl83Serum cholesterol level QTL 834.33blood cholesterol amount (VT:0000180)103621155669161158Rat
1578779Tcas10Tongue tumor susceptibility QTL 103.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)103179628176796281Rat
631565Hcuc4Hepatic copper content QTL 44.15liver copper amount (VT:0003065)liver copper weight to liver dry weight ratio (CMO:0001512)106743947373950209Rat
152025227Bw195Body weight QTL 1955.73body mass (VT:0001259)104748901769161158Rat
1298069Bp168Blood pressure QTL 1685.5blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)102702353598502431Rat
8657410Bp374Blood pressure QTL 374heart left ventricle size trait (VT:0002753)heart left ventricle end-diastolic diameter (CMO:0000982)1067476608107713808Rat
2293669Bmd33Bone mineral density QTL 334.50.0001femur strength trait (VT:0010010)femoral neck polar moment of inertia (CMO:0001670)102744378772443787Rat
152025224Bw193Body weight QTL 1936.47body mass (VT:0001259)105216243375582749Rat
61449Ciaa2CIA Autoantibody QTL 27.1blood autoantibody amount (VT:0003725)calculated serum anti-type 2 collagen antibody titer (CMO:0001279)1063719161107713808Rat
631552Vetf2Vascular elastic tissue fragility QTL 24.50.0002aorta elastic tissue integrity trait (VT:0010556)artery internal elastic lamina non-tumorous lesion count (CMO:0001913)103550938391417879Rat
631557Bp136Blood pressure QTL 1360.003arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)105686844076129113Rat
61325Aia5Adjuvant induced arthritis QTL 50.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023948641107713808Rat
1298078Stresp5Stress response QTL 52.990.00025blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)1042546145107713808Rat
2293679Bmd30Bone mineral density QTL 303.50.0001femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)102744378772443787Rat
1549831Bss6Bone structure and strength QTL 64lumbar vertebra strength trait (VT:0010574)vertebra ultimate force (CMO:0001678)1058073360103073360Rat
12903252Cm113Cardiac mass QTL 1130.047heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)1066817119107713808Rat
70164Bw21Body weight QTL 214.360.00005body mass (VT:0001259)body weight (CMO:0000012)105429633699451733Rat
2298548Neuinf7Neuroinflammation QTL 73.4nervous system integrity trait (VT:0010566)spinal cord RT1-B protein level (CMO:0002132)1064939013107713808Rat
61463Bp12Blood pressure QTL 126.30.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)104183127886831278Rat
1579919Bp281Blood pressure QTL 2810.01arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)105046480295464802Rat
2300218Hpcl2Hepatic cholesterol level QTL 2liver cholesterol amount (VT:0010498)liver cholesterol level (CMO:0001597)104552916496099749Rat
8694173Bw149Body weight QTL 1494.380.001body mass (VT:0001259)body weight gain (CMO:0000420)104493935989939359Rat
70171Cari1Carrageenan-induced inflammation QTL 14.90.0005hypodermis integrity trait (VT:0010550)inflammatory exudate volume (CMO:0001429)1054296227107713808Rat
12903269Am15Aortic mass QTL 150.042aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)1066817119107713808Rat
10450493Bp382Blood pressure QTL 3820.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)105086028895860288Rat
724527Bp148Blood pressure QTL 1480.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)102895035373950353Rat
12903266Cm114Cardiac mass QTL 1140.02heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)1066817119107713808Rat
2300171Bmd58Bone mineral density QTL 584.90.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)102744378772443787Rat
61354Pia10Pristane induced arthritis QTL 100.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023948641107713808Rat
2301967Cm73Cardiac mass QTL 734.55heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)101499153586964295Rat
2313103Bss80Bone structure and strength QTL 8020.0001tibia strength trait (VT:1000284)tibia midshaft endosteal cross-sectional area (CMO:0001716)1062556066107556066Rat
70188BpQTLcluster1Blood pressure QTL cluster 14.864arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)14282327487823274Rat
12880372Am12Aortic mass QTL 120.003aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)1066817119107713808Rat
2313105Bss79Bone structure and strength QTL 791.80.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)1062556066107556066Rat
12880375Kidm66Kidney mass QTL 660.009kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1066817119107713808Rat
1357344Bp249Blood pressure QTL 2490.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)106724133498502431Rat
9589030Epfw9Epididymal fat weight QTL 919.240.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)104493935989939359Rat
2293652Bmd22Bone mineral density QTL 224.90.0001femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)102744378772443787Rat
2316949Gluco60Glucose level QTL 603.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1014991535107556066Rat
12880370Cm105Cardiac mass QTL 1050.008heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)1066817119107713808Rat
70198BpQTLcluster9Blood pressure QTL cluster 92.94arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)104282327487823274Rat
12880371Cm106Cardiac mass QTL 1060.007heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)1066817119107713808Rat
2306970Anxrr22Anxiety related response QTL 225.95fear/anxiety-related behavior trait (VT:1000241)number of periods of voluntary immobility (CMO:0001045)106184349698710773Rat
11565453Kidm58Kidney mass QTL 580.002kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1066817119107713808Rat
7387312Bw125Body weight QTL 12530.0047retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight (CMO:0000356)1065390777107713808Rat
2317029Aia19Adjuvant induced arthritis QTL 192.98joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)106747660873695498Rat
724556Pur2Proteinuria QTL 25.5urine protein amount (VT:0005160)urine protein level (CMO:0000591)102293137391127454Rat
8662860Vetf10Vascular elastic tissue fragility QTL 10artery integrity trait (VT:0010639)number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)10666092373950353Rat
2306792Ean4Experimental allergic neuritis QTL 44nervous system integrity trait (VT:0010566)IFNG-secreting splenocyte count (CMO:0002122)104949549294495492Rat
61387Bp1Blood pressure QTL 15.1arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1052269185107713808Rat
2317039Aia6Adjuvant induced arthritis QTL 64.31joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)106747660873695498Rat
1354587Kidm21Kidney mass QTL 213.3kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)101553301273695498Rat
634329Pia15Pristane induced arthritis QTL 153.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)102466212373695339Rat
2298481Eau9Experimental allergic uveoretinitis QTL 90.0169uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)106413959783061459Rat
2298480Eau7Experimental allergic uveoretinitis QTL 70.0049uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)103550938380509383Rat
1358915Stresp7Stress response QTL 73.52blood norepinephrine amount (VT:0005663)plasma norepinephrine level (CMO:0001010)1065307813107713808Rat
70363Bp71Blood pressure QTL 710.04arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1061843496106843496Rat
61402Niddm3Non-insulin dependent diabetes mellitus QTL 34.58blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)106184363383061236Rat
1331791Cm31Cardiac mass QTL 313.84606heart mass (VT:0007028)heart wet weight (CMO:0000069)102980091091417879Rat
2289985Bp305Blood pressure QTL 305arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)102907697874076978Rat
631530Tls3T-lymphoma susceptibility QTL 300.0001thymus integrity trait (VT:0010555)percentage of study population developing T-cell lymphomas during a period of time (CMO:0001911)102758722696099902Rat
1354608Cm33Cardiac mass QTL 332.8heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)105530797293608131Rat
1558643Cm44Cardiac mass QTL 444.80.0000368heart mass (VT:0007028)heart wet weight (CMO:0000069)1061843496100198886Rat
8552805Bw145Body weight QTL 1452.2body mass (VT:0001259)change in body weight to body weight ratio (CMO:0002216)104360879388608793Rat
631267Cia20Collagen induced arthritis QTL 203.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023948641107713808Rat
2293705Bmd25Bone mineral density QTL 257.10.0001femur mineral mass (VT:0010011)compact volumetric bone mineral density (CMO:0001730)102744378772443787Rat
631269Cia22Collagen induced arthritis QTL 228.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040535708107713808Rat
1576308Schws1Schwannoma susceptibility QTL 10.0041nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)1040535708107713808Rat
631268Cia21Collagen induced arthritis QTL 213.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1014991535107713808Rat
7207811Bmd90Bone mineral density QTL 905.2femur size trait (VT:1000369)femoral neck cross-sectional area (CMO:0001697)104994371094943710Rat
631270Cia23Collagen induced arthritis QTL 233.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040535708107713808Rat
1581559Eae18Experimental allergic encephalomyelitis QTL 180.00002nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis severity score (CMO:0001419)1066108888107555881Rat
1576311Pia26Pristane induced arthritis QTL 26joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)103112911376129113Rat
7411614Foco18Food consumption QTL 180.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)104493935989939359Rat
6893336Cm75Cardiac mass QTL 750.10.87heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)1061843496100198886Rat
631547Bp87Blood pressure QTL 874.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)104786912992869129Rat
61427Cia16Collagen induced arthritis QTL 163.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)10686461896620484Rat
2292436Bp310Blood pressure QTL 310arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)105060467795604677Rat
12880050Am10Aortic mass QTL 100.016aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)103950348784503487Rat
6893342Cm78Cardiac mass QTL 780.10.88heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)103550938388177745Rat
634354Rends3Renal damage susceptibility QTL 30.05kidney blood vessel morphology trait (VT:0000530)organ lesion measurement (CMO:0000677)1061997479106997479Rat
2301405Cm69Cardiac mass QTL 690.031heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)1066817119107713808Rat
631542Bp82Blood pressure QTL 826.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)102702353599451848Rat

Markers in Region
D10Wox51  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21068,011,827 - 68,012,018 (+)MAPPERmRatBN7.2
Rnor_6.01070,428,844 - 70,429,034NCBIRnor6.0
Rnor_5.01070,062,921 - 70,063,111UniSTSRnor5.0
RGSC_v3.41071,294,871 - 71,295,061UniSTSRGSC3.4
Celera1066,955,281 - 66,955,471UniSTS
Cytogenetic Map10q26UniSTS
D10Chm244  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21067,997,294 - 67,997,472 (+)MAPPERmRatBN7.2
Rnor_6.01070,414,348 - 70,414,525NCBIRnor6.0
Rnor_5.01070,048,485 - 70,048,662UniSTSRnor5.0
RGSC_v3.41071,280,375 - 71,280,552UniSTSRGSC3.4
Cytogenetic Map10q26UniSTS
D10Chm179  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21067,993,369 - 67,993,618 (+)MAPPERmRatBN7.2
Rnor_6.01070,415,748 - 70,415,996NCBIRnor6.0
Rnor_6.01070,410,423 - 70,410,671NCBIRnor6.0
Rnor_5.01070,049,790 - 70,050,072UniSTSRnor5.0
Rnor_5.01070,041,305 - 70,041,553UniSTSRnor5.0
RGSC_v3.41071,276,450 - 71,276,698UniSTSRGSC3.4
RGSC_v3.41071,281,775 - 71,282,023UniSTSRGSC3.4
Celera1066,942,185 - 66,942,433UniSTS
Cytogenetic Map10q26UniSTS
D10Mco86  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21067,993,370 - 67,993,646 (+)MAPPERmRatBN7.2
Rnor_6.01070,415,749 - 70,416,024NCBIRnor6.0
Rnor_6.01070,410,424 - 70,410,699NCBIRnor6.0
Rnor_5.01070,049,791 - 70,050,100UniSTSRnor5.0
Rnor_5.01070,041,306 - 70,041,581UniSTSRnor5.0
RGSC_v3.41071,276,451 - 71,276,726UniSTSRGSC3.4
RGSC_v3.41071,281,776 - 71,282,051UniSTSRGSC3.4
Celera1066,942,186 - 66,942,461UniSTS
Cytogenetic Map10q26UniSTS
RH132185  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21068,017,879 - 68,018,082 (+)MAPPERmRatBN7.2
Rnor_6.01070,434,896 - 70,435,098NCBIRnor6.0
Rnor_5.01070,068,973 - 70,069,175UniSTSRnor5.0
RGSC_v3.41071,300,923 - 71,301,125UniSTSRGSC3.4
Celera1066,961,334 - 66,961,536UniSTS
Cytogenetic Map10q26UniSTS
AU046963  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21067,993,465 - 67,993,640 (+)MAPPERmRatBN7.2
Rnor_6.01070,415,844 - 70,416,018NCBIRnor6.0
Rnor_6.01070,410,519 - 70,410,693NCBIRnor6.0
Rnor_5.01070,049,886 - 70,050,094UniSTSRnor5.0
Rnor_5.01070,041,401 - 70,041,575UniSTSRnor5.0
RGSC_v3.41071,276,546 - 71,276,720UniSTSRGSC3.4
RGSC_v3.41071,281,871 - 71,282,045UniSTSRGSC3.4
Celera1066,942,281 - 66,942,455UniSTS
Cytogenetic Map10q26UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 156 91 90 59 92 59 6 356 192 11 135 81 92 31 9 9

Sequence


Ensembl Acc Id: ENSRNOT00000078046   ⟹   ENSRNOP00000074064
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1068,000,028 - 68,018,138 (+)Ensembl
Rnor_6.0 Ensembl1070,411,738 - 70,435,156 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000078946
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1070,412,352 - 70,417,724 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000079325   ⟹   ENSRNOP00000072460
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1067,994,632 - 68,018,138 (+)Ensembl
Rnor_6.0 Ensembl1070,417,108 - 70,435,156 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000087606   ⟹   ENSRNOP00000073148
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1068,508,916 - 68,513,991 (+)Ensembl
mRatBN7.2 Ensembl1068,011,383 - 68,016,458 (+)Ensembl
RefSeq Acc Id: NM_053687   ⟹   NP_446139
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81068,492,220 - 68,515,673 (+)NCBI
mRatBN7.21067,994,685 - 68,018,140 (+)NCBI
Rnor_6.01070,411,738 - 70,435,156 (+)NCBI
Rnor_5.01070,045,721 - 70,069,233 (+)NCBI
RGSC_v3.41071,277,765 - 71,301,183 (+)RGD
Celera1066,943,545 - 66,961,594 (+)RGD
Sequence:
RefSeq Acc Id: XM_008767933   ⟹   XP_008766155
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81068,492,135 - 68,515,674 (+)NCBI
mRatBN7.21067,994,601 - 68,018,141 (+)NCBI
Rnor_6.01070,411,686 - 70,435,162 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017596949   ⟹   XP_017452438
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81068,492,135 - 68,515,674 (+)NCBI
mRatBN7.21067,994,601 - 68,018,141 (+)NCBI
Rnor_6.01070,411,686 - 70,435,162 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039085031   ⟹   XP_038940959
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81068,492,135 - 68,515,674 (+)NCBI
mRatBN7.21067,994,601 - 68,018,141 (+)NCBI
RefSeq Acc Id: NP_446139   ⟸   NM_053687
- UniProtKB: Q9TPX1 (UniProtKB/TrEMBL),   A0A0G2K750 (UniProtKB/TrEMBL),   A0A0G2K4S0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008766155   ⟸   XM_008767933
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_017452438   ⟸   XM_017596949
- Peptide Label: isoform X2
- UniProtKB: A0A0G2K4S0 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000072460   ⟸   ENSRNOT00000079325
Ensembl Acc Id: ENSRNOP00000074064   ⟸   ENSRNOT00000078046
RefSeq Acc Id: XP_038940959   ⟸   XM_039085031
- Peptide Label: isoform X1
- UniProtKB: Q9TPX1 (UniProtKB/TrEMBL),   A0A0G2K750 (UniProtKB/TrEMBL),   A0A0G2K4S0 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000073148   ⟸   ENSRNOT00000087606
Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9TPX1-F1-model_v2 AlphaFold Q9TPX1 1-587 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13697525
Promoter ID:EPDNEW_R8050
Type:initiation region
Name:Slfn4_1
Description:schlafen 4
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R8051  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01070,411,716 - 70,411,776EPDNEW
RGD ID:13697530
Promoter ID:EPDNEW_R8051
Type:initiation region
Name:Slfn4_2
Description:schlafen 4
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R8050  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01070,417,014 - 70,417,074EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620455 AgrOrtholog
BioCyc Gene G2FUF-23905 BioCyc
Ensembl Genes ENSRNOG00000057092 Ensembl
  ENSRNOG00000062983 Ensembl, UniProtKB/TrEMBL
  ENSRNOG00000063541 Ensembl
Ensembl Transcript ENSRNOT00000087606.3 UniProtKB/TrEMBL
Gene3D-CATH 3.30.950.30 UniProtKB/TrEMBL
InterPro ATPase_AAA-4 UniProtKB/TrEMBL
  Poxin-SLFN/SLFN_N UniProtKB/TrEMBL
  Schlafen UniProtKB/TrEMBL
  Schlafen_AAA_dom_sf UniProtKB/TrEMBL
  SLFN_GTPase-like UniProtKB/TrEMBL
KEGG Report rno:114247 UniProtKB/TrEMBL
NCBI Gene 114247 ENTREZGENE
PANTHER PTHR12155 UniProtKB/TrEMBL
  SCHLAFEN 3-RELATED UniProtKB/TrEMBL
Pfam AAA_4 UniProtKB/TrEMBL
  B3R UniProtKB/TrEMBL
  SLFN_GTPase-like UniProtKB/TrEMBL
PhenoGen Slfn4 PhenoGen
RatGTEx ENSRNOG00000057092 RatGTEx
  ENSRNOG00000062983 RatGTEx
  ENSRNOG00000063541 RatGTEx
UniProt A0A0G2K4S0 ENTREZGENE, UniProtKB/TrEMBL
  A0A0G2K750 ENTREZGENE, UniProtKB/TrEMBL
  Q9QYU5_RAT UniProtKB/TrEMBL
  Q9TPX1 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-10-04 Slfn4  schlafen family member 4  Slfn4  schlafen 4  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2015-10-28 Slfn4l  schlafen 4l  Slfn3  schlafen 3  Name and Symbol changed 629549 APPROVED
2015-10-28 Slfn4  schlafen 4  Slfn4l  schlafen 4l  Name and Symbol changed 629549 APPROVED
2015-07-29 Slfn3  schlafen 3  LOC102553282  uncharacterized LOC102553282  Data merged from RGD:7631613 737654 PROVISIONAL
2013-12-18 LOC102553282  uncharacterized LOC102553282      Symbol and Name status set to provisional 70820 PROVISIONAL
2008-09-17 Slfn3  schlafen 3  Cdk107  CDK107  Data merged from RGD:621336 1643240 APPROVED
2004-09-10 Slfn3  schlafen 3  Slfn4  schlafen 4  Symbol and Name updated 1299863 APPROVED
2002-08-07 Slfn4  schlafen 4      Symbol and Name status set to provisional 70820 PROVISIONAL
2002-08-07 Cdk107  CDK107      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_process indirectly activates an interferon-responsive enhancer element in a nuclear factor-kappaB pathway-dependent manner 633613