Plpp3 (phospholipid phosphatase 3) - Rat Genome Database

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Gene: Plpp3 (phospholipid phosphatase 3) Rattus norvegicus
Analyze
Symbol: Plpp3
Name: phospholipid phosphatase 3
RGD ID: 620454
Description: Predicted to enable integrin binding activity and lipid phosphatase activity. Predicted to be involved in several processes, including cell-cell adhesion mediated by integrin; protein stabilization; and sphingolipid metabolic process. Predicted to act upstream of or within several processes, including Bergmann glial cell differentiation; positive regulation of peptidyl-tyrosine phosphorylation; and regulation of signal transduction. Located in endoplasmic reticulum membrane. Orthologous to human PLPP3 (phospholipid phosphatase 3); PARTICIPATES IN ether lipid metabolic pathway; ether lipid metabolic pathway; Fc gamma receptor mediated signaling pathway; INTERACTS WITH 17alpha-ethynylestradiol; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: differentially expressed in rat intestine; differentially expressed in rat intestine 42; Dri42; ER transmembrane protein Dri 42; lipid phosphate phosphohydrolase 3; PAP-2b; PAP2-beta; PAP2b; phosphatidate phosphohydrolase type 2b; phosphatidic acid phosphatase 2b; phosphatidic acid phosphatase type 2B; Ppap2b
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85125,156,000 - 125,231,119 (+)NCBIGRCr8
mRatBN7.25119,927,085 - 120,002,206 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5119,927,085 - 120,002,205 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx5122,548,651 - 122,624,021 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05124,271,713 - 124,347,083 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05124,322,955 - 124,398,328 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.05124,690,214 - 124,765,499 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5124,690,214 - 124,765,498 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05128,551,196 - 128,626,138 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45126,121,416 - 126,197,099 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.15126,126,641 - 126,202,324 (+)NCBI
Celera5118,477,102 - 118,551,973 (+)NCBICelera
Cytogenetic Map5q34NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-demecolcine  (ISO)
(-)-epigallocatechin 3-gallate  (ISO)
(1->4)-beta-D-glucan  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3',4,4',5-Pentachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (ISO)
2-amino-2-deoxy-D-glucopyranose  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (EXP,ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3-methylcholanthrene  (ISO)
3H-1,2-dithiole-3-thione  (EXP)
4,4'-diaminodiphenylmethane  (ISO)
4-\{[(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)carbonyl]amino\}benzoic acid  (ISO)
6alpha-methylprednisolone  (ISO)
acetamide  (EXP)
aflatoxin B1  (ISO)
aldehydo-D-glucosamine  (EXP)
all-trans-retinoic acid  (ISO)
amitrole  (EXP)
ammonium chloride  (EXP)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
ATP  (ISO)
azathioprine  (ISO)
benzene  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
beta-D-glucosamine  (EXP)
beta-lapachone  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
buspirone  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
cadmium sulfate  (ISO)
calyculin a  (ISO)
cannabidiol  (ISO)
carbon nanotube  (ISO)
chloroprene  (EXP)
choline  (ISO)
cisplatin  (ISO)
clofibric acid  (EXP)
cobalt dichloride  (EXP)
cocaine  (EXP)
copper(II) sulfate  (ISO)
crocidolite asbestos  (ISO)
Cuprizon  (EXP)
cyclosporin A  (ISO)
dexamethasone  (ISO)
diallyl disulfide  (ISO)
diarsenic trioxide  (ISO)
dibutyl phthalate  (EXP)
dieldrin  (EXP)
dioxygen  (ISO)
diuron  (EXP)
divanadium pentaoxide  (ISO)
doxorubicin  (ISO)
elemental selenium  (ISO)
endosulfan  (EXP)
entinostat  (ISO)
epoxiconazole  (ISO)
ethanol  (ISO)
finasteride  (EXP)
fipronil  (EXP)
flutamide  (EXP)
folic acid  (ISO)
formaldehyde  (ISO)
FR900359  (ISO)
fulvestrant  (ISO)
furan  (EXP)
gamma-hexachlorocyclohexane  (EXP)
genistein  (ISO)
gentamycin  (EXP)
glafenine  (EXP)
graphite  (EXP)
hydrogen chloride  (ISO)
hydrogen peroxide  (ISO)
indometacin  (ISO)
isoflavones  (ISO)
isotretinoin  (ISO)
L-methionine  (ISO)
lead diacetate  (ISO)
metacetamol  (ISO)
methapyrilene  (EXP)
methimazole  (EXP)
methotrexate  (ISO)
methylmercury chloride  (ISO)
N-nitrosodiethylamine  (EXP)
nefazodone  (EXP)
nickel dichloride  (EXP,ISO)
nimesulide  (EXP)
oxaliplatin  (EXP)
ozone  (ISO)
paracetamol  (EXP,ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP,ISO)
pirinixic acid  (EXP,ISO)
piroxicam  (ISO)
potassium chromate  (ISO)
prednisolone  (ISO)
pregnenolone 16alpha-carbonitrile  (EXP)
progesterone  (ISO)
propiconazole  (EXP,ISO)
raloxifene  (ISO)
Securinine  (ISO)
selenium atom  (ISO)
serpentine asbestos  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
sodium aurothiomalate  (ISO)
sodium dichromate  (EXP)
sodium dodecyl sulfate  (ISO)
sodium fluoride  (ISO)
succimer  (ISO)
sulfadimethoxine  (EXP)
tamoxifen  (ISO)
testosterone enanthate  (ISO)
tetrachloromethane  (EXP,ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
topotecan  (EXP)
triadimefon  (EXP)
triclosan  (ISO)
triphenyl phosphate  (EXP)
Triptolide  (EXP)
troglitazone  (ISO)
trovafloxacin  (EXP)
tunicamycin  (ISO)
valdecoxib  (EXP)
valproic acid  (ISO)
vinclozolin  (EXP)
vincristine  (ISO)
vitamin E  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. The Dri 42 gene, whose expression is up-regulated during epithelial differentiation, encodes a novel endoplasmic reticulum resident transmembrane protein. Barila D, etal., J Biol Chem 1996 Nov 22;271(47):29928-36.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
4. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
5. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
6. GOA pipeline RGD automated data pipeline
7. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
8. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
Additional References at PubMed
PMID:8055940   PMID:9305923   PMID:9705349   PMID:12660161   PMID:12925589   PMID:14527693   PMID:16099422   PMID:17005594   PMID:20123964   PMID:21319224   PMID:22871113   PMID:23376485  
PMID:23591818  


Genomics

Comparative Map Data
Plpp3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85125,156,000 - 125,231,119 (+)NCBIGRCr8
mRatBN7.25119,927,085 - 120,002,206 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5119,927,085 - 120,002,205 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx5122,548,651 - 122,624,021 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05124,271,713 - 124,347,083 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05124,322,955 - 124,398,328 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.05124,690,214 - 124,765,499 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5124,690,214 - 124,765,498 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05128,551,196 - 128,626,138 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45126,121,416 - 126,197,099 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.15126,126,641 - 126,202,324 (+)NCBI
Celera5118,477,102 - 118,551,973 (+)NCBICelera
Cytogenetic Map5q34NCBI
PLPP3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38156,494,761 - 56,579,563 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl156,494,761 - 56,645,301 (-)EnsemblGRCh38hg38GRCh38
GRCh37156,960,433 - 57,045,236 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36156,733,021 - 56,817,845 (-)NCBINCBI36Build 36hg18NCBI36
Celera155,245,253 - 55,330,133 (-)NCBICelera
Cytogenetic Map1p32.2NCBI
HuRef155,072,892 - 55,157,775 (-)NCBIHuRef
CHM1_1157,072,622 - 57,160,617 (-)NCBICHM1_1
T2T-CHM13v2.0156,373,591 - 56,458,441 (-)NCBIT2T-CHM13v2.0
Plpp3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394105,014,544 - 105,089,964 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl4105,014,544 - 105,089,961 (+)EnsemblGRCm39 Ensembl
GRCm384105,157,347 - 105,232,767 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4105,157,347 - 105,232,764 (+)EnsemblGRCm38mm10GRCm38
MGSCv374104,829,952 - 104,905,372 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv364104,655,279 - 104,730,699 (+)NCBIMGSCv36mm8
Celera4103,508,199 - 103,583,768 (+)NCBICelera
Cytogenetic Map4C6NCBI
cM Map449.18NCBI
Plpp3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554643,081,334 - 3,197,413 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554643,122,420 - 3,197,359 (+)NCBIChiLan1.0ChiLan1.0
PLPP3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21170,181,721 - 170,332,442 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11169,400,091 - 169,484,785 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0155,779,343 - 55,862,717 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1157,489,178 - 57,573,307 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl157,489,178 - 57,573,398 (-)Ensemblpanpan1.1panPan2
PLPP3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1552,924,443 - 53,006,298 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl552,923,833 - 53,005,493 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha552,992,430 - 53,074,349 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0553,112,365 - 53,194,538 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl553,112,379 - 53,194,536 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1553,055,985 - 53,137,860 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0553,001,878 - 53,083,760 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0553,386,869 - 53,468,888 (+)NCBIUU_Cfam_GSD_1.0
Plpp3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505870,341,999 - 70,423,866 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365224,992,322 - 5,074,313 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365224,992,333 - 5,074,295 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PLPP3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl6155,800,678 - 155,894,912 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.16155,800,838 - 155,894,919 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.26143,642,088 - 143,734,081 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PLPP3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12076,382,041 - 76,466,497 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2076,382,079 - 76,477,847 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603340,825,335 - 40,909,946 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Plpp3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248623,550,968 - 3,627,058 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248623,550,498 - 3,627,061 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Plpp3
404 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:739
Count of miRNA genes:283
Interacting mature miRNAs:381
Transcripts:ENSRNOT00000011237
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1331796Thshl2Thyroid stimulating hormone level QTL 22.3blood thyroid-stimulating hormone amount (VT:0005119)serum thyroid stimulating hormone level (CMO:0001248)597059760147465714Rat
1549845Scl44Serum cholesterol level QTL 446blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)540128307148607290Rat
8552960Pigfal15Plasma insulin-like growth factor 1 level QTL 15blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)5111416838156416838Rat
70212Niddm25Non-insulin dependent diabetes mellitus QTL 253.54blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)51131345958Rat
1298070Scl18Serum cholesterol level QTL 183.7blood LDL cholesterol amount (VT:0000181)calculated plasma low density lipoprotein cholesterol level (CMO:0001245)579584860124584860Rat
7794739Bp372Blood pressure QTL 3720.0058arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5117913688125222967Rat
61452Ciaa5CIA Autoantibody QTL 53.5blood autoantibody amount (VT:0003725)calculated serum anti-rat type 2 collagen autoantibody titer (CMO:0001281)594858972143070159Rat
1331801Rf33Renal function QTL 334.149kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)543726656129132602Rat
1582230Bw78Body weight QTL 783.20.0016epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)5119085612128034027Rat
7411582Foco3Food consumption QTL 37.50.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)587468046132468046Rat
61393Bp7Blood pressure QTL 74.50.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)560293434161481680Rat
1598859Cm66Cardiac mass QTL 662heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)579584860124584860Rat
7207486Bss109Bone structure and strength QTL 109femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)5106906205151906205Rat
7207481Bss106Bone structure and strength QTL 1067.9femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)5106906205151906205Rat
1302790Scl20Serum cholesterol level QTL 206.40.0001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)582394392166664054Rat
1578766Tcas11Tongue tumor susceptibility QTL 114.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)546711509161317411Rat
1549838Bss4Bone structure and strength QTL 49.2femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)5106906205151906205Rat
2317753Glom24Glomerulus QTL 243.1kidney glomerulus integrity trait (VT:0010546)kidney sclerotic glomeruli count to total glomeruli count ratio (CMO:0001269)597570330136479578Rat
7411564Bw135Body weight QTL 1350.001body mass (VT:0001259)body weight gain (CMO:0000420)587468046132468046Rat
8657050Bw146Body weight QTL 14619.840.001body mass (VT:0001259)body weight gain (CMO:0000420)5108938288153938288Rat
1576312Emca8Estrogen-induced mammary cancer QTL 84.1mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)550328551141643988Rat
7411601Foco12Food consumption QTL 1219.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)587468046132468046Rat
1641912Alcrsp18Alcohol response QTL 18response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)535189153141643988Rat
1576314Eutr1Estrogen induced uterine response QTL 1uterus integrity trait (VT:0010575)pyometritis severity score (CMO:0002009)52138965166875058Rat
2317056Wbc3White blood cell count QTL 32.510.01leukocyte quantity (VT:0000217)white blood cell count (CMO:0000027)5105999803150999803Rat
1598846Bp293Blood pressure QTL 2933.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)579584860124584860Rat
1598847Cm62Cardiac mass QTL 623.4heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)5108845856153845856Rat
1578673Bmd13Bone mineral density QTL 134.9femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)5103689353148689353Rat
1358909Kidm25Kidney mass QTL 251.87kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)590067849128034027Rat
70189Mcs5Mammary carcinoma susceptibility QTL 510.51mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)555805606132207589Rat
8694441Bw169Body weight QTL 16917.610.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)5111416838156416838Rat
7207488Bss110Bone structure and strength QTL 18.4femur strength trait (VT:0010010)femur stiffness (CMO:0001674)5106906205151906205Rat
631527Tls1T-lymphoma susceptibility QTL 100.001thymus integrity trait (VT:0010555)post-insult time to onset of T-cell lymphoma (CMO:0001907)590450144135450144Rat
7207491Bss112Bone structure and strength QTL 1127femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)5106906205151906205Rat
8694389Bw160Body weight QTL 1606.170.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)5111416838156416838Rat
1354598Srn6Serum renin concentration QTL 63.8blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)569540295151018848Rat
2290448Scl54Serum cholesterol level QTL 542.93blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)531663789131345958Rat
61426Scl2Serum cholesterol level QTL 27.30.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)559793399143070159Rat
8694198Abfw3Abdominal fat weight QTL 316.130.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)5111416838156416838Rat
1298086Bp156Blood pressure QTL 156arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)584132602129132602Rat
2306971Anxrr21Anxiety related response QTL 219.47fear/anxiety-related behavior trait (VT:1000241)number of entries into a discrete space in an experimental apparatus (CMO:0000960)566174080124160948Rat
1298089Scl14Serum cholesterol level QTL 145.80.0004blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)5108845856153845856Rat
1358895Bp254Blood pressure QTL 2543.60.0003arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)558829236128034027Rat
1358889Bp261Blood pressure QTL 2612.86arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)590067849128034027Rat
6903316Bw113Body weight QTL 11320.0103body mass (VT:0001259)body weight (CMO:0000012)587765973132765973Rat
1358187Emca1Estrogen-induced mammary cancer QTL 14.4mammary gland integrity trait (VT:0010552)post-insult time to mammary tumor formation (CMO:0000345)599216724148607142Rat

Markers in Region
RH129678  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25120,001,921 - 120,002,132 (+)MAPPERmRatBN7.2
Rnor_6.05124,765,215 - 124,765,425NCBIRnor6.0
Rnor_5.05128,625,854 - 128,626,064UniSTSRnor5.0
RGSC_v3.45126,196,815 - 126,197,025UniSTSRGSC3.4
Celera5118,551,689 - 118,551,899UniSTS
Cytogenetic Map5q34UniSTS
BF410958  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25119,936,995 - 119,937,085 (+)MAPPERmRatBN7.2
Rnor_6.05124,700,124 - 124,700,213NCBIRnor6.0
Rnor_5.05128,561,106 - 128,561,195UniSTSRnor5.0
RGSC_v3.45126,131,326 - 126,131,415UniSTSRGSC3.4
Celera5118,487,012 - 118,487,101UniSTS
Cytogenetic Map5q34UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000011237   ⟹   ENSRNOP00000011237
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl5119,927,085 - 120,002,205 (+)Ensembl
Rnor_6.0 Ensembl5124,690,214 - 124,765,498 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000106902   ⟹   ENSRNOP00000095295
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl5119,927,085 - 119,995,656 (+)Ensembl
RefSeq Acc Id: NM_138905   ⟹   NP_620260
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85125,156,000 - 125,231,119 (+)NCBI
mRatBN7.25119,927,085 - 120,002,206 (+)NCBI
Rnor_6.05124,690,214 - 124,765,499 (+)NCBI
Rnor_5.05128,551,196 - 128,626,138 (+)NCBI
RGSC_v3.45126,121,416 - 126,197,099 (+)RGD
Celera5118,477,102 - 118,551,973 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_620260 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH72544 (Get FASTA)   NCBI Sequence Viewer  
  CAA69106 (Get FASTA)   NCBI Sequence Viewer  
  EDL97884 (Get FASTA)   NCBI Sequence Viewer  
  EDL97885 (Get FASTA)   NCBI Sequence Viewer  
  EDL97886 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000011237.3
  ENSRNOP00000095295.1
GenBank Protein P97544 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_620260   ⟸   NM_138905
- UniProtKB: P97544 (UniProtKB/Swiss-Prot),   Q6IMX4 (UniProtKB/TrEMBL),   A6JRU2 (UniProtKB/TrEMBL),   F7FJE5 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000011237   ⟸   ENSRNOT00000011237
Ensembl Acc Id: ENSRNOP00000095295   ⟸   ENSRNOT00000106902
Protein Domains
Phosphatidic acid phosphatase type 2/haloperoxidase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P97544-F1-model_v2 AlphaFold P97544 1-312 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13693874
Promoter ID:EPDNEW_R4399
Type:multiple initiation site
Name:Plpp3_1
Description:phospholipid phosphatase 3
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.05124,690,244 - 124,690,304EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620454 AgrOrtholog
BioCyc Gene G2FUF-40477 BioCyc
Ensembl Genes ENSRNOG00000008116 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000011237.6 UniProtKB/TrEMBL
  ENSRNOT00000106902.1 UniProtKB/TrEMBL
Gene3D-CATH Phosphatidic acid phosphatase type 2/haloperoxidase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7105872 IMAGE-MGC_LOAD
InterPro P_Acid_Pase_2/haloperoxi_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  P_Acid_Pase_2/haloperoxidase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PLPP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:192270 UniProtKB/TrEMBL
MGC_CLONE MGC:91483 IMAGE-MGC_LOAD
NCBI Gene 192270 ENTREZGENE
PANTHER PTHR10165 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR10165:SF79 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam PAP2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Plpp3 PhenoGen
RatGTEx ENSRNOG00000008116 RatGTEx
SMART acidPPc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF48317 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I6AND8_RAT UniProtKB/TrEMBL
  A6JRU2 ENTREZGENE, UniProtKB/TrEMBL
  F7FJE5 ENTREZGENE, UniProtKB/TrEMBL
  P97544 ENTREZGENE, UniProtKB/Swiss-Prot
  Q6IMX4 ENTREZGENE
UniProt Secondary Q6IMX4 UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-10-26 Plpp3  phospholipid phosphatase 3  Ppap2b  phosphatidic acid phosphatase type 2B  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-30 Ppap2b  phosphatidic acid phosphatase type 2B    ER transmembrane protein Dri 42  Name updated 1299863 APPROVED
2004-09-10 Ppap2b  ER transmembrane protein Dri 42  Dri42    Symbol and Name updated 1299863 APPROVED
2002-08-07 Dri42  ER transmembrane protein Dri 42      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_cellular_localization resident in the endoplasmic reticulum 632577
gene_expression expressed in intestine 632577
gene_regulation increased during epithelial differentiation 632577