Plpp3 (phospholipid phosphatase 3) - Rat Genome Database

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Gene: Plpp3 (phospholipid phosphatase 3) Rattus norvegicus
Analyze
Symbol: Plpp3
Name: phospholipid phosphatase 3
RGD ID: 620454
Description: Predicted to enable delta-catenin binding activity; integrin binding activity; and lipid phosphatase activity. Predicted to be involved in several processes, including positive regulation of cell adhesion; regulation of DNA-templated transcription; and sphingolipid metabolic process. Predicted to act upstream of or within several processes, including Bergmann glial cell differentiation; positive regulation of peptidyl-tyrosine phosphorylation; and regulation of signal transduction. Located in endoplasmic reticulum membrane. Orthologous to human PLPP3 (phospholipid phosphatase 3); PARTICIPATES IN ether lipid metabolic pathway; ether lipid metabolic pathway; Fc gamma receptor mediated signaling pathway; INTERACTS WITH 17alpha-ethynylestradiol; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: differentially expressed in rat intestine; differentially expressed in rat intestine 42; Dri42; ER transmembrane protein Dri 42; lipid phosphate phosphohydrolase 3; PAP-2b; PAP2-beta; PAP2b; phosphatidate phosphohydrolase type 2b; phosphatidic acid phosphatase 2b; phosphatidic acid phosphatase type 2B; Ppap2b
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85125,156,000 - 125,231,119 (+)NCBIGRCr8
mRatBN7.25119,927,085 - 120,002,206 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5119,927,085 - 120,002,205 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx5122,548,651 - 122,624,021 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05124,271,713 - 124,347,083 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05124,322,955 - 124,398,328 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.05124,690,214 - 124,765,499 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5124,690,214 - 124,765,498 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05128,551,196 - 128,626,138 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45126,121,416 - 126,197,099 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.15126,126,641 - 126,202,324 (+)NCBI
Celera5118,477,102 - 118,551,973 (+)NCBICelera
Cytogenetic Map5q34NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Object Symbol
Species
Term
Qualifier
Evidence
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Reference
Notes
Source
Original Reference(s)
Plpp3RatCardiomegaly  ISOPLPP3 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:28982073
Plpp3Ratcoronary artery disease  ISOPLPP3 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:21378990
Plpp3RatVentricular Dysfunction, Left  ISOPLPP3 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:28982073

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Original Reference(s)
Plpp3Rat(-)-demecolcine increases expressionISOPLPP3 (Homo sapiens)6480464Demecolcine results in increased expression of PLPP3 mRNACTDPMID:23649840
Plpp3Rat(-)-epigallocatechin 3-gallate multiple interactionsISOPLPP3 (Homo sapiens)6480464[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of PLPP3 mRNACTDPMID:22079256
Plpp3Rat(1->4)-beta-D-glucan multiple interactionsISOPlpp3 (Mus musculus)6480464[perfluorooctane sulfonic acid co-treated with Cellulose] results in decreased expression of PLPP3 mRNACTDPMID:36331819
Plpp3Rat1,2-dichloroethane increases expressionISOPlpp3 (Mus musculus)6480464ethylene dichloride results in increased expression of PLPP3 mRNA and ethylene dichloride results in increased expression of PPAP2B mRNACTDPMID:28189721 and PMID:28960355
Plpp3Rat1,2-dimethylhydrazine multiple interactionsISOPlpp3 (Mus musculus)6480464[1 and 2-Dimethylhydrazine co-treated with Folic Acid] results in decreased expression of PLPP3 mRNACTDPMID:22206623
Plpp3Rat17alpha-ethynylestradiol affects expressionISOPlpp3 (Mus musculus)6480464Ethinyl Estradiol affects the expression of PLPP3 mRNACTDPMID:17555576
Plpp3Rat17alpha-ethynylestradiol decreases expressionEXP 6480464Ethinyl Estradiol results in decreased expression of PLPP3 mRNACTDPMID:17557909
Plpp3Rat17beta-estradiol multiple interactionsISOPLPP3 (Homo sapiens)6480464[Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of PLPP3 mRNA and [Estradiol co-treated with TGFB1 protein] results in decreased expression of PLPP3 mRNACTDPMID:19619570 and PMID:30165855
Plpp3Rat17beta-estradiol decreases expressionEXP 6480464Estradiol results in decreased expression of PPAP2B mRNACTDPMID:32145629
Plpp3Rat17beta-estradiol increases expressionISOPLPP3 (Homo sapiens)6480464Estradiol results in increased expression of PLPP3 mRNACTDPMID:23019147
Plpp3Rat17beta-estradiol decreases expressionISOPLPP3 (Homo sapiens)6480464Estradiol results in decreased expression of PLPP3 mRNACTDPMID:16474171 and PMID:19619570
Plpp3Rat17beta-hydroxy-5alpha-androstan-3-one increases expressionISOPLPP3 (Homo sapiens)6480464Dihydrotestosterone results in increased expression of PLPP3 mRNACTDPMID:29581250
Plpp3Rat2,2',4,4'-Tetrabromodiphenyl ether increases expressionISOPLPP3 (Homo sapiens)64804642 more ...CTDPMID:23146750
Plpp3Rat2,3',4,4',5-Pentachlorobiphenyl increases expressionISOPlpp3 (Mus musculus)64804642 more ...CTDPMID:31388691
Plpp3Rat2,3,7,8-tetrachlorodibenzodioxine multiple interactionsISOPLPP3 (Homo sapiens)6480464[Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of PLPP3 mRNACTDPMID:19619570
Plpp3Rat2,3,7,8-tetrachlorodibenzodioxine decreases expressionEXP 6480464Tetrachlorodibenzodioxin results in decreased expression of PLPP3 mRNACTDPMID:33387578
Plpp3Rat2,3,7,8-tetrachlorodibenzodioxine affects expressionEXP 6480464Tetrachlorodibenzodioxin affects the expression of PLPP3 mRNACTDPMID:34747641
Plpp3Rat2,3,7,8-tetrachlorodibenzodioxine affects expressionISOPlpp3 (Mus musculus)6480464Tetrachlorodibenzodioxin affects the expression of PLPP3 mRNACTDPMID:16962184 more ...
Plpp3Rat2,3,7,8-tetrachlorodibenzodioxine decreases expressionISOPLPP3 (Homo sapiens)6480464Tetrachlorodibenzodioxin results in decreased expression of PLPP3 mRNACTDPMID:11007951 more ...
Plpp3Rat2,3,7,8-tetrachlorodibenzodioxine increases expressionISOPlpp3 (Mus musculus)6480464Tetrachlorodibenzodioxin results in increased expression of PLPP3 mRNACTDPMID:18796159 more ...

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Biological Process
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Original Reference(s)
Plpp3RatBergmann glial cell differentiation acts_upstream_of_or_withinISOPlpp3 (Mus musculus)1624291MGI:2176173 more ...RGDPMID:21319224
Plpp3Ratblood vessel development acts_upstream_of_or_withinISOPlpp3 (Mus musculus)1624291MGI:2674217 PMID:12925589RGDPMID:12925589
Plpp3Ratcell adhesion acts_upstream_of_or_withinISOPlpp3 (Mus musculus)1624291 PMID:16099422RGDPMID:16099422
Plpp3Ratcell-cell adhesion acts_upstream_of_or_withinISOPlpp3 (Mus musculus)1624291 PMID:16099422RGDPMID:16099422
Plpp3Ratcell-cell adhesion involved_inIBAMGI:1915166 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Plpp3Ratcell-cell adhesion mediated by integrin involved_inISSUniProtKB:O144951600115GO_REF:0000024UniProtGO_REF:0000024
Plpp3Ratcell-cell adhesion mediated by integrin involved_inISOPLPP3 (Homo sapiens)1624291 PMID:12660161RGDPMID:12660161
Plpp3Ratceramide metabolic process involved_inISSUniProtKB:O144951600115GO_REF:0000024UniProtGO_REF:0000024
Plpp3Ratceramide metabolic process involved_inISOPLPP3 (Homo sapiens)1624291 PMID:9305923 and PMID:9705349RGDPMID:9305923 and PMID:9705349
Plpp3Ratgastrulation with mouth forming second acts_upstream_of_or_withinISOPlpp3 (Mus musculus)1624291MGI:2674217 PMID:12925589RGDPMID:12925589
Plpp3Ratintegrin-mediated signaling pathway acts_upstream_ofISSUniProtKB:O144951600115GO_REF:0000024UniProtGO_REF:0000024
Plpp3Ratintegrin-mediated signaling pathway acts_upstream_ofISOPLPP3 (Homo sapiens)1624291 PMID:12660161RGDPMID:12660161
Plpp3Ratlipid metabolic process involved_inIEAUniProtKB-KW:KW-04431600115GO_REF:0000043UniProtGO_REF:0000043
Plpp3Ratphospholipid dephosphorylation involved_inISOPLPP3 (Homo sapiens)1624291 PMID:9305923 and PMID:9705349RGDPMID:9305923 and PMID:9705349
Plpp3Ratphospholipid dephosphorylation involved_inIBAMGI:108412 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Plpp3Ratphospholipid dephosphorylation involved_inISSUniProtKB:O144951600115GO_REF:0000024UniProtGO_REF:0000024
Plpp3Ratphospholipid metabolic process involved_inISSUniProtKB:O144951600115GO_REF:0000024UniProtGO_REF:0000024
Plpp3Ratphospholipid metabolic process acts_upstream_of_or_withinISOPlpp3 (Mus musculus)1624291MGI:2674217 PMID:12925589RGDPMID:12925589
Plpp3Ratphospholipid metabolic process involved_inIBAMGI:108412 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Plpp3Ratphospholipid metabolic process involved_inIEAInterPro:IPR0432161600115GO_REF:0000002InterProGO_REF:0000002
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Cellular Component
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Original Reference(s)
Plpp3Ratadherens junction located_inISOPLPP3 (Homo sapiens)1624291 PMID:20123964RGDPMID:20123964
Plpp3Ratbasolateral plasma membrane located_inISOPLPP3 (Homo sapiens)1624291 PMID:14527693RGDPMID:14527693
Plpp3Ratbasolateral plasma membrane located_inIEAUniProtKB-SubCell:SL-00261600115GO_REF:0000044UniProtGO_REF:0000044
Plpp3Ratendoplasmic reticulum located_inIEAUniProtKB-KW:KW-02561600115GO_REF:0000043UniProtGO_REF:0000043
Plpp3Ratendoplasmic reticulum exit site located_inISSUniProtKB:O144951600115GO_REF:0000024UniProtGO_REF:0000024
Plpp3Ratendoplasmic reticulum exit site located_inISOPLPP3 (Homo sapiens)1624291 PMID:23591818RGDPMID:23591818
Plpp3Ratendoplasmic reticulum membrane  IDA 632577 RGD 
Plpp3Ratendoplasmic reticulum membrane located_inIEAUniProtKB-SubCell:SL-00971600115GO_REF:0000044UniProtGO_REF:0000044
Plpp3Ratendoplasmic reticulum-Golgi intermediate compartment membrane located_inISOPLPP3 (Homo sapiens)1624291 PMID:23591818RGDPMID:23591818
Plpp3Ratendoplasmic reticulum-Golgi intermediate compartment membrane located_inIEAUniProtKB-SubCell:SL-00991600115GO_REF:0000044UniProtGO_REF:0000044
Plpp3Ratendoplasmic reticulum-Golgi intermediate compartment membrane located_inISSUniProtKB:O144951600115GO_REF:0000024UniProtGO_REF:0000024
Plpp3RatGolgi apparatus located_inISSUniProtKB:O144951600115GO_REF:0000024UniProtGO_REF:0000024
Plpp3RatGolgi apparatus located_inIEAUniProtKB-KW:KW-03331600115GO_REF:0000043UniProtGO_REF:0000043
Plpp3RatGolgi apparatus located_inIEAUniProtKB-SubCell:SL-01321600115GO_REF:0000044UniProtGO_REF:0000044
Plpp3RatGolgi apparatus located_inISOPLPP3 (Homo sapiens)1624291 PMID:23591818RGDGO_REF:0000052 and PMID:23591818
Plpp3RatGolgi membrane located_inIEAUniProtKB-SubCell:SL-01341600115GO_REF:0000044UniProtGO_REF:0000044
Plpp3Ratmembrane located_inIEAUniProtKB-SubCell:SL-01621600115GO_REF:0000044UniProtGO_REF:0000044
Plpp3Ratmembrane located_inISOPLPP3 (Homo sapiens)1624291 PMID:9305923 and PMID:9705349RGDPMID:9305923 and PMID:9705349
Plpp3Ratmembrane located_inISSUniProtKB:O144951600115GO_REF:0000024UniProtGO_REF:0000024
Plpp3Ratmembrane located_inIEAUniProtKB-KW:KW-04721600115GO_REF:0000043UniProtGO_REF:0000043
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Molecular Function
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Original Reference(s)
Plpp3Ratceramide-1-phosphate phosphatase activity enablesISSUniProtKB:O144951600115GO_REF:0000024UniProtGO_REF:0000024
Plpp3Ratceramide-1-phosphate phosphatase activity enablesISOPLPP3 (Homo sapiens)1624291 PMID:9705349RGDPMID:9705349
Plpp3Ratdelta-catenin binding enablesISOPLPP3 (Homo sapiens)1624291UniProtKB:O60716 and PMID:20123964RGDPMID:20123964
Plpp3Rathydrolase activity enablesIEAUniProtKB-KW:KW-03781600115GO_REF:0000043UniProtGO_REF:0000043
Plpp3Ratintegrin binding enablesISOPLPP3 (Homo sapiens)1624291 PMID:12660161RGDPMID:12660161
Plpp3Ratintegrin binding enablesISOPlpp3 (Mus musculus)1624291 PMID:16099422RGDPMID:16099422
Plpp3Ratintegrin binding enablesISSUniProtKB:O144951600115GO_REF:0000024UniProtGO_REF:0000024
Plpp3Ratlipid phosphatase activity enablesISOPlpp3 (Mus musculus)1624291MGI:2674217 PMID:12925589RGDPMID:12925589
Plpp3Ratphosphatidate phosphatase activity enablesISSUniProtKB:O144951600115GO_REF:0000024UniProtGO_REF:0000024
Plpp3Ratphosphatidate phosphatase activity enablesIEARHEA:274291600115GO_REF:0000116RHEAGO_REF:0000116
Plpp3Ratphosphatidate phosphatase activity enablesIBAMGI:108412 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Plpp3Ratphosphatidate phosphatase activity enablesIEAEC:3.1.3.41600115GO_REF:0000003UniProtGO_REF:0000003
Plpp3Ratphosphatidate phosphatase activity enablesISOPLPP3 (Homo sapiens)1624291 PMID:9305923 and PMID:9705349RGDPMID:9305923 and PMID:9705349
Plpp3Ratprotein binding enablesISOPLPP3 (Homo sapiens)1624291UniProtKB:O60716 and PMID:20123964RGDPMID:20123964
Plpp3Ratsphingosine-1-phosphate phosphatase activity enablesISSUniProtKB:O144951600115GO_REF:0000024UniProtGO_REF:0000024
Plpp3Ratsphingosine-1-phosphate phosphatase activity enablesIEARHEA:275181600115GO_REF:0000116RHEAGO_REF:0000116
Plpp3Ratsphingosine-1-phosphate phosphatase activity enablesISOPlpp3 (Mus musculus)1624291MGI:2176173 more ...RGDPMID:21319224
Plpp3Ratsphingosine-1-phosphate phosphatase activity enablesIBAMGI:1915166 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Plpp3Ratsphingosine-1-phosphate phosphatase activity enablesISOPLPP3 (Homo sapiens)1624291 PMID:9305923 and PMID:9705349RGDPMID:9305923 and PMID:9705349
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Imported Annotations - KEGG (archival)

Object Symbol
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Original Reference(s)
Plpp3Ratether lipid metabolic pathway  IEA 6907045 KEGGrno:00565
Plpp3Ratether lipid metabolic pathway  IEA 6907045 KEGGrno:00565
Plpp3RatFc gamma receptor mediated signaling pathway  IEA 6907045 KEGGrno:04666
Plpp3Ratglycerolipid metabolic pathway  IEA 6907045 KEGGrno:00561
Plpp3Ratglycerophospholipid metabolic pathway  IEA 6907045 KEGGrno:00564
Plpp3Ratsphingolipid metabolic pathway  IEA 6907045 KEGGrno:00600

#
Reference Title
Reference Citation
1. The Dri 42 gene, whose expression is up-regulated during epithelial differentiation, encodes a novel endoplasmic reticulum resident transmembrane protein. Barila D, etal., J Biol Chem 1996 Nov 22;271(47):29928-36.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
4. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
5. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
6. GOA pipeline RGD automated data pipeline
7. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
8. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
PMID:8055940   PMID:9305923   PMID:9705349   PMID:12660161   PMID:12925589   PMID:14527693   PMID:16099422   PMID:17005594   PMID:20123964   PMID:21319224   PMID:22871113   PMID:23376485  
PMID:23591818  



Plpp3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85125,156,000 - 125,231,119 (+)NCBIGRCr8
mRatBN7.25119,927,085 - 120,002,206 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5119,927,085 - 120,002,205 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx5122,548,651 - 122,624,021 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05124,271,713 - 124,347,083 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05124,322,955 - 124,398,328 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.05124,690,214 - 124,765,499 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5124,690,214 - 124,765,498 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05128,551,196 - 128,626,138 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45126,121,416 - 126,197,099 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.15126,126,641 - 126,202,324 (+)NCBI
Celera5118,477,102 - 118,551,973 (+)NCBICelera
Cytogenetic Map5q34NCBI
PLPP3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38156,494,761 - 56,579,563 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl156,494,761 - 56,645,301 (-)EnsemblGRCh38hg38GRCh38
GRCh37156,960,433 - 57,045,236 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36156,733,021 - 56,817,845 (-)NCBINCBI36Build 36hg18NCBI36
Celera155,245,253 - 55,330,133 (-)NCBICelera
Cytogenetic Map1p32.2NCBI
HuRef155,072,892 - 55,157,775 (-)NCBIHuRef
CHM1_1157,072,622 - 57,160,617 (-)NCBICHM1_1
T2T-CHM13v2.0156,373,591 - 56,458,441 (-)NCBIT2T-CHM13v2.0
Plpp3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394105,014,544 - 105,089,964 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl4105,014,544 - 105,089,961 (+)EnsemblGRCm39 Ensembl
GRCm384105,157,347 - 105,232,767 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4105,157,347 - 105,232,764 (+)EnsemblGRCm38mm10GRCm38
MGSCv374104,829,952 - 104,905,372 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv364104,655,279 - 104,730,699 (+)NCBIMGSCv36mm8
Celera4103,508,199 - 103,583,768 (+)NCBICelera
Cytogenetic Map4C6NCBI
cM Map449.18NCBI
Plpp3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554643,081,334 - 3,197,413 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554643,122,420 - 3,197,359 (+)NCBIChiLan1.0ChiLan1.0
PLPP3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21170,181,721 - 170,332,442 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11169,400,091 - 169,484,785 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0155,779,343 - 55,862,717 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1157,489,178 - 57,573,307 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl157,489,178 - 57,573,398 (-)Ensemblpanpan1.1panPan2
PLPP3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1552,924,443 - 53,006,298 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl552,923,833 - 53,005,493 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha552,992,430 - 53,074,349 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0553,112,365 - 53,194,538 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl553,112,379 - 53,194,536 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1553,055,985 - 53,137,860 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0553,001,878 - 53,083,760 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0553,386,869 - 53,468,888 (+)NCBIUU_Cfam_GSD_1.0
Plpp3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505870,341,999 - 70,423,866 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365224,992,322 - 5,074,313 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365224,992,333 - 5,074,295 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PLPP3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl6155,800,678 - 155,894,912 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.16155,800,838 - 155,894,919 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.26143,642,088 - 143,734,081 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PLPP3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12076,382,041 - 76,466,497 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2076,382,079 - 76,477,847 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603340,825,335 - 40,909,946 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Plpp3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248623,550,968 - 3,627,058 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248623,550,498 - 3,627,061 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

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Variants in Plpp3
404 total Variants

Predicted Target Of
Summary Value
Count of predictions:739
Count of miRNA genes:283
Interacting mature miRNAs:381
Transcripts:ENSRNOT00000011237
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 46 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
1331796Thshl2Thyroid stimulating hormone level QTL 22.3blood thyroid-stimulating hormone amount (VT:0005119)serum thyroid stimulating hormone level (CMO:0001248)597059760147465714Rat
1549845Scl44Serum cholesterol level QTL 446blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)540128307148607290Rat
8552960Pigfal15Plasma insulin-like growth factor 1 level QTL 15blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)5111416838156416838Rat
70212Niddm25Non-insulin dependent diabetes mellitus QTL 253.54blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)51131345958Rat
1298070Scl18Serum cholesterol level QTL 183.7blood LDL cholesterol amount (VT:0000181)calculated plasma low density lipoprotein cholesterol level (CMO:0001245)579584860124584860Rat
7794739Bp372Blood pressure QTL 3720.0058arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5117913688125222967Rat
61452Ciaa5CIA Autoantibody QTL 53.5blood autoantibody amount (VT:0003725)calculated serum anti-rat type 2 collagen autoantibody titer (CMO:0001281)594858972143070159Rat
1331801Rf33Renal function QTL 334.149kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)543726656129132602Rat
1582230Bw78Body weight QTL 783.20.0016epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)5119085612128034027Rat
7411582Foco3Food consumption QTL 37.50.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)587468046132468046Rat

1 to 10 of 46 rows
RH129678  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr85125,230,834 - 125,231,045 (+)Marker Load Pipeline
mRatBN7.25120,001,921 - 120,002,132 (+)MAPPERmRatBN7.2
Rnor_6.05124,765,215 - 124,765,425NCBIRnor6.0
Rnor_5.05128,625,854 - 128,626,064UniSTSRnor5.0
RGSC_v3.45126,196,815 - 126,197,025UniSTSRGSC3.4
Celera5118,551,689 - 118,551,899UniSTS
Cytogenetic Map5q34UniSTS
BF410958  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25119,936,995 - 119,937,085 (+)MAPPERmRatBN7.2
Rnor_6.05124,700,124 - 124,700,213NCBIRnor6.0
Rnor_5.05128,561,106 - 128,561,195UniSTSRnor5.0
RGSC_v3.45126,131,326 - 126,131,415UniSTSRGSC3.4
Celera5118,487,012 - 118,487,101UniSTS
Cytogenetic Map5q34UniSTS




alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31



Ensembl Acc Id: ENSRNOT00000011237   ⟹   ENSRNOP00000011237
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl5119,927,085 - 120,002,205 (+)Ensembl
Rnor_6.0 Ensembl5124,690,214 - 124,765,498 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000106902   ⟹   ENSRNOP00000095295
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl5119,927,085 - 119,995,656 (+)Ensembl
RefSeq Acc Id: NM_138905   ⟹   NP_620260
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85125,156,000 - 125,231,119 (+)NCBI
mRatBN7.25119,927,085 - 120,002,206 (+)NCBI
Rnor_6.05124,690,214 - 124,765,499 (+)NCBI
Rnor_5.05128,551,196 - 128,626,138 (+)NCBI
RGSC_v3.45126,121,416 - 126,197,099 (+)RGD
Celera5118,477,102 - 118,551,973 (+)RGD
Sequence:
Protein RefSeqs NP_620260 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH72544 (Get FASTA)   NCBI Sequence Viewer  
  CAA69106 (Get FASTA)   NCBI Sequence Viewer  
  EDL97884 (Get FASTA)   NCBI Sequence Viewer  
  EDL97885 (Get FASTA)   NCBI Sequence Viewer  
  EDL97886 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000011237
GenBank Protein P97544 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_620260   ⟸   NM_138905
- UniProtKB: P97544 (UniProtKB/Swiss-Prot),   Q6IMX4 (UniProtKB/TrEMBL),   A6JRU2 (UniProtKB/TrEMBL),   F7FJE5 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000011237   ⟸   ENSRNOT00000011237
Ensembl Acc Id: ENSRNOP00000095295   ⟸   ENSRNOT00000106902
Name Modeler Protein Id AA Range Protein Structure
AF-P97544-F1-model_v2 AlphaFold P97544 1-312 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13693874
Promoter ID:EPDNEW_R4399
Type:multiple initiation site
Name:Plpp3_1
Description:phospholipid phosphatase 3
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.05124,690,244 - 124,690,304EPDNEW


1 to 22 of 22 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-40477 BioCyc
Ensembl Genes ENSRNOG00000008116 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000011237 ENTREZGENE
Gene3D-CATH Phosphatidic acid phosphatase type 2/haloperoxidase UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7105872 IMAGE-MGC_LOAD
InterPro P_Acid_Pase_2/haloperoxi_sf UniProtKB/Swiss-Prot
  P_Acid_Pase_2/haloperoxidase UniProtKB/Swiss-Prot
  PLPP UniProtKB/Swiss-Prot
MGC_CLONE MGC:91483 IMAGE-MGC_LOAD
NCBI Gene 192270 ENTREZGENE
PANTHER PTHR10165 UniProtKB/Swiss-Prot
  PTHR10165:SF79 UniProtKB/Swiss-Prot
Pfam PAP2 UniProtKB/Swiss-Prot
PhenoGen Plpp3 PhenoGen
RatGTEx ENSRNOG00000008116 RatGTEx
SMART acidPPc UniProtKB/Swiss-Prot
Superfamily-SCOP SSF48317 UniProtKB/Swiss-Prot
UniProt A0A8I6AND8_RAT UniProtKB/TrEMBL
  A6JRU2 ENTREZGENE, UniProtKB/TrEMBL
  F7FJE5 ENTREZGENE, UniProtKB/TrEMBL
  P97544 ENTREZGENE, UniProtKB/Swiss-Prot
  Q6IMX4 ENTREZGENE
1 to 22 of 22 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-10-26 Plpp3  phospholipid phosphatase 3  Ppap2b  phosphatidic acid phosphatase type 2B  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-30 Ppap2b  phosphatidic acid phosphatase type 2B    ER transmembrane protein Dri 42  Name updated 1299863 APPROVED
2004-09-10 Ppap2b  ER transmembrane protein Dri 42  Dri42    Symbol and Name updated 1299863 APPROVED
2002-08-07 Dri42  ER transmembrane protein Dri 42      Symbol and Name status set to provisional 70820 PROVISIONAL

Note Type Note Reference
gene_cellular_localization resident in the endoplasmic reticulum 632577
gene_expression expressed in intestine 632577
gene_regulation increased during epithelial differentiation 632577