Cfh (complement factor H) - Rat Genome Database

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Gene: Cfh (complement factor H) Rattus norvegicus
Analyze
Symbol: Cfh
Name: complement factor H
RGD ID: 620428
Description: Predicted to enable several functions, including complement component C3b binding activity; heparan sulfate proteoglycan binding activity; and heparin binding activity. Involved in several processes, including cellular response to hydrogen peroxide; cellular response to lipopolysaccharide; and cellular response to type II interferon. Located in extracellular space. Used to study atypical hemolytic-uremic syndrome. Biomarker of amphetamine abuse; membranous glomerulonephritis; obstructive jaundice; proteinuria (multiple); and retinal degeneration. Human ortholog(s) of this gene implicated in several diseases, including atypical hemolytic-uremic syndrome; eye disease (multiple); hemolytic-uremic syndrome; lupus nephritis; and systemic lupus erythematosus. Orthologous to human CFH (complement factor H); PARTICIPATES IN coagulation cascade pathway; complement system pathway; Staphylococcus aureus infection pathway; INTERACTS WITH (+)-schisandrin B; 17alpha-ethynylestradiol; 17beta-estradiol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: adrenomedullin binding protein-1; AMBP-1; AMBP1; complement component factor H; complement inhibitory factor H; Fh; platelet complement factor H
RGD Orthologs
Human
Mouse
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81354,063,079 - 54,164,523 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1354,062,531 - 54,164,532 (-)EnsemblGRCr8
mRatBN7.21351,512,376 - 51,613,829 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1351,511,828 - 51,613,838 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1354,104,450 - 54,199,522 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01355,392,371 - 55,487,454 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01352,655,305 - 52,757,017 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01356,979,155 - 57,080,540 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1356,978,607 - 57,080,622 (-)Ensemblrn6Rnor6.0
Rnor_5.01361,997,444 - 62,094,826 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41353,252,249 - 53,355,987 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1351,770,541 - 51,871,522 (-)NCBICelera
RGSC_v3.11353,266,346 - 53,370,041 (-)NCBI
Cytogenetic Map13q13NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View
age related macular degeneration 4  (ISO,ISS)
amphetamine abuse  (IEP,ISO)
anterior uveitis  (ISO)
atypical hemolytic-uremic syndrome  (IMP,ISO,ISS)
Bacteremia  (ISO)
basal laminar drusen  (ISO)
brain infarction  (ISO)
C3 Glomerulopathy 3  (ISO)
cardiovascular system disease  (ISO)
Cerebral Hemorrhage  (ISO)
Chemical and Drug Induced Liver Injury  (ISO)
Choroidal Neovascularization  (ISO)
chronic kidney disease  (ISO)
Complement Factor H Deficiency  (ISO)
COVID-19  (ISO)
diabetic retinopathy  (ISO)
Experimental Arthritis  (ISO)
focal segmental glomerulosclerosis  (ISO)
fundus dystrophy  (ISO)
genetic disease  (ISO)
glaucoma  (ISO)
glomerulonephritis  (ISO)
Glomerulonephritis with Isolated C3 Deposits and Factor H Deficiency  (ISO)
hemolytic-uremic syndrome  (ISO,ISS)
Hemorrhagic Shock  (IEP,ISO)
Intestinal Ischemia  (IEP)
kidney disease  (ISO)
Kidney Reperfusion Injury  (IEP,ISO)
Liver Reperfusion Injury  (IEP,ISO)
lupus nephritis  (ISO)
macular degeneration  (ISO)
membranoproliferative glomerulonephritis  (ISO,ISS)
membranous glomerulonephritis  (IEP)
Meningococcal Infections  (ISO)
Multifocal Choroiditis  (ISO)
multiple sclerosis  (ISO)
nephrosis  (IEP)
obstructive jaundice  (IEP)
optic atrophy  (ISO)
panuveitis  (ISO)
Pneumococcal Infections  (ISO)
Polypoidal Choroidal Vasculopathy  (ISO)
posterior uveitis  (ISO)
primary immunodeficiency disease  (ISO)
proteinuria  (IEP)
psoriasis  (ISO)
Reperfusion Injury  (IEP)
retinal degeneration  (IEP)
retinal detachment  (ISO)
retinal drusen  (ISO)
retinitis pigmentosa 1  (ISO)
sarcoidosis  (ISO)
Sepsis  (IEP,ISO)
squamous cell carcinoma  (ISO)
stroke  (IEP)
Systemic Inflammatory Response Syndrome  (ISO)
systemic lupus erythematosus  (ISO)
Thrombotic Microangiopathies  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(1->4)-beta-D-glucan  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1-naphthyl isothiocyanate  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-tribromophenol  (ISO)
2,4,6-trinitrobenzenesulfonic acid  (ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2,4-dinitrotoluene  (EXP)
2,6-dinitrotoluene  (EXP)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
acetamide  (EXP)
aflatoxin B1  (EXP,ISO)
ammonium chloride  (EXP)
arsenite(3-)  (ISO)
astemizole  (EXP)
Azoxymethane  (ISO)
benzo[a]pyrene  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
butanal  (ISO)
butyric acid  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
carbon nanotube  (ISO)
chlorpromazine  (ISO)
chromium(6+)  (ISO)
cisplatin  (ISO)
clofibrate  (EXP,ISO)
clorgyline  (ISO)
cobalt dichloride  (EXP)
cocaine  (EXP)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) chloride  (ISO)
crocidolite asbestos  (ISO)
cyclosporin A  (ISO)
cylindrospermopsin  (ISO)
dextran sulfate  (ISO)
dichloroacetic acid  (ISO)
diclofenac  (ISO)
diquat  (ISO)
diuron  (EXP)
doxorubicin  (EXP,ISO)
elemental selenium  (ISO)
endosulfan  (EXP,ISO)
erianin  (ISO)
ethanol  (EXP,ISO)
flutamide  (EXP)
fumonisin B1  (ISO)
furan  (EXP)
gentamycin  (EXP)
inulin  (ISO)
isoprenaline  (ISO)
lipopolysaccharide  (ISO)
N-Acetyl-S-(1,2-dichlorovinyl)-cysteine  (ISO)
N-nitrosodiethylamine  (EXP)
nefazodone  (EXP)
nickel atom  (ISO)
nimesulide  (EXP)
nitrofen  (EXP)
okadaic acid  (ISO)
olanzapine  (ISO)
oxaliplatin  (EXP)
ozone  (ISO)
paracetamol  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
phenobarbital  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
pirinixic acid  (ISO)
progesterone  (EXP,ISO)
propiconazole  (ISO)
resveratrol  (EXP)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
selenium atom  (ISO)
senecionine  (ISO)
silicon dioxide  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (EXP)
sotorasib  (ISO)
tamoxifen  (ISO)
testosterone enanthate  (ISO)
tetrachloromethane  (EXP)
thioacetamide  (EXP)
thiram  (ISO)
titanium dioxide  (ISO)
topotecan  (EXP)
trametinib  (ISO)
trichostatin A  (ISO)
trimellitic anhydride  (ISO)
triphenyl phosphate  (ISO)
Triptolide  (EXP,ISO)
triptonide  (ISO)
troglitazone  (ISO)
valproic acid  (ISO)
vancomycin  (ISO)
vinclozolin  (EXP)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
activation of membrane attack complex  (ISO)
angiogenesis  (ISO)
ATP metabolic process  (ISO)
blood coagulation  (IEA)
bone development  (ISO)
cartilage development  (ISO)
cellular response to hydrogen peroxide  (IEP)
cellular response to lipopolysaccharide  (IEP,ISO)
cellular response to type II interferon  (IEP)
central nervous system myelination  (ISO)
complement activation  (IBA,IEA,IEP,ISO)
complement activation, alternative pathway  (IEA,ISO)
determination of adult lifespan  (ISO)
gene expression  (ISO)
glomerulus development  (ISO)
immune complex clearance  (ISO)
immune response  (ISO)
immune system process  (IEA)
immunoglobulin mediated immune response  (ISO)
inflammatory response  (ISO)
inflammatory response to wounding  (ISO)
innate immune response  (IEA)
kidney development  (ISO)
mitochondrial DNA metabolic process  (ISO)
mitochondrial gene expression  (ISO)
mitochondrion organization  (ISO)
monocyte aggregation  (ISO)
neuromuscular process  (ISO)
neutrophil homeostasis  (ISO)
organ or tissue specific immune response  (ISO)
photoreceptor cell differentiation  (ISO)
platelet aggregation  (ISO)
proteolysis  (ISO)
regulation of complement activation  (IDA,IEA,ISO)
regulation of complement activation, alternative pathway  (ISO)
regulation of complement-dependent cytotoxicity  (ISO)
response to cytokine  (ISO)
response to dietary excess  (ISO)
retina development in camera-type eye  (ISO)
retinal pigment epithelium development  (ISO)
retinal rod cell development  (ISO)
vascular associated smooth muscle cell differentiation  (ISO)
visual perception  (ISO)

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Association of Single Nucleotide Polymorphisms in CFH, ARMS2 and HTRA1 Genes with Risk of Age-related Macular Degeneration in Egyptian Patients. Abbas RO and Azzazy HM, Ophthalmic Genet. 2013 Jan 30.
2. Genetic variability in complement activation modulates the systemic inflammatory response syndrome in children. Agbeko RS, etal., Pediatr Crit Care Med. 2010 Sep;11(5):561-7.
3. Mouse podocyte complement factor H: the functional analog to human complement receptor 1. Alexander JJ, etal., J Am Soc Nephrol. 2007 Apr;18(4):1157-66. Epub 2007 Mar 7.
4. Complement Factor H Y402H polymorphism is associated with an increased risk of mortality after intracerebral hemorrhage. Appelboom G, etal., J Clin Neurosci. 2011 Nov;18(11):1439-43. Epub 2011 Aug 25.
5. Genome-wide association study identifies two susceptibility loci for exudative age-related macular degeneration in the Japanese population. Arakawa S, etal., Nat Genet. 2011 Sep 11;43(10):1001-4. doi: 10.1038/ng.938.
6. Targeted inhibition of the complement alternative pathway with complement receptor 2 and factor H attenuates collagen antibody-induced arthritis in mice. Banda NK, etal., J Immunol. 2009 Nov 1;183(9):5928-37. Epub 2009 Oct 14.
7. Complement factor H mutations and gene polymorphisms in haemolytic uraemic syndrome: the C-257T, the A2089G and the G2881T polymorphisms are strongly associated with the disease. Caprioli J, etal., Hum Mol Genet. 2003 Dec 15;12(24):3385-95. Epub 2003 Oct 28.
8. Adrenomedullin and adrenomedullin-binding protein-1 downregulate inflammatory cytokines and attenuate tissue injury after gut ischemia-reperfusion. Carrizo GJ, etal., Surgery. 2007 Feb;141(2):245-53. Epub 2006 Sep 14.
9. Major single nucleotide polymorphisms in polypoidal choroidal vasculopathy: a comparative analysis between Thai and other Asian populations. Chantaren P, etal., Clin Ophthalmol. 2012;6:465-71. doi: 10.2147/OPTH.S30529. Epub 2012 Mar 22.
10. Peripheral administration of human adrenomedullin and its binding protein attenuates stroke-induced apoptosis and brain injury in rats. Chaung WW, etal., Mol Med. 2011;17(9-10):1075-83. doi: 10.2119/molmed.2010.00104. Epub 2011 Jun 17.
11. Complement deposition and microglial activation in the outer retina in light-induced retinopathy: inhibition by a 5-HT1A agonist. Collier RJ, etal., Invest Ophthalmol Vis Sci. 2011 Oct 11;52(11):8108-16. doi: 10.1167/iovs.10-6418.
12. CFH (rs1410996), HTRA1 (rs112000638) and ARMS2 (rs10490923) Gene Polymorphisms are Associated with AMD Risk in Spanish Patients. Cruz-Gonzalez F, etal., Ophthalmic Genet. 2013 Mar 27.
13. Rat complement factor H: molecular cloning, sequencing and quantification with a newly established ELISA. Demberg T, etal., Scand J Immunol 2002 Aug;56(2):149-60.
14. Analysis of major alleles associated with age-related macular degeneration in patients with multifocal choroiditis: strong association with complement factor H. Ferrara DC, etal., Arch Ophthalmol. 2008 Nov;126(11):1562-6. doi: 10.1001/archopht.126.11.1562.
15. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
16. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
17. No association between complement factor H gene polymorphism and exudative age-related macular degeneration in Japanese. Gotoh N, etal., Hum Genet. 2006 Aug;120(1):139-43. Epub 2006 May 19.
18. Binding of complement factor H (fH) to Neisseria meningitidis is specific for human fH and inhibits complement activation by rat and rabbit sera. Granoff DM, etal., Infect Immun. 2009 Feb;77(2):764-9. doi: 10.1128/IAI.01191-08. Epub 2008 Dec 1.
19. Complement factor H-related protein 1 deficiency and factor H antibodies in pediatric patients with atypical hemolytic uremic syndrome. Hofer J, etal., Clin J Am Soc Nephrol. 2013 Mar;8(3):407-15. doi: 10.2215/CJN.01260212. Epub 2012 Dec 14.
20. Complement regulator factor H in multiple sclerosis. Ingram G, etal., J Cell Biochem. 2011 Oct;112(10):2653-4. doi: 10.1002/jcb.23204.
21. Mutations in genes encoding complement inhibitors CD46 and CFH affect the age at nephritis onset in patients with systemic lupus erythematosus. Jonsen A, etal., Arthritis Res Ther. 2011 Dec 15;13(6):R206.
22. Intravitreal human complement factor H in a rat model of laser-induced choroidal neovascularisation. Kim SJ, etal., Br J Ophthalmol. 2013 Mar;97(3):367-70. doi: 10.1136/bjophthalmol-2012-302307. Epub 2012 Dec 19.
23. Association of the Y402H polymorphism in complement factor H gene and neovascular age-related macular degeneration in Chinese patients. Lau LI, etal., Invest Ophthalmol Vis Sci. 2006 Aug;47(8):3242-6.
24. Complement mutation-associated de novo thrombotic microangiopathy following kidney transplantation. Le Quintrec M, etal., Am J Transplant. 2008 Aug;8(8):1694-701. doi: 10.1111/j.1600-6143.2008.02297.x. Epub 2008 Jun 28.
25. Association analysis of CFH, C2, BF, and HTRA1 gene polymorphisms in Chinese patients with polypoidal choroidal vasculopathy. Lee KY, etal., Invest Ophthalmol Vis Sci. 2008 Jun;49(6):2613-9. doi: 10.1167/iovs.07-0860.
26. Genetic factors for choroidal neovascularization associated with high myopia. Leveziel N, etal., Invest Ophthalmol Vis Sci. 2012 Jul 27;53(8):5004-9. doi: 10.1167/iovs.12-9538.
27. Mutations in alternative pathway complement proteins in American patients with atypical hemolytic uremic syndrome. Maga TK, etal., Hum Mutat. 2010 Jun;31(6):E1445-60. doi: 10.1002/humu.21256.
28. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
29. Hypocomplementemic autosomal recessive hemolytic uremic syndrome with decreased factor H. Ohali M, etal., Pediatr Nephrol. 1998 Oct;12(8):619-24.
30. Increased plasma concentrations of complement modulating proteins (C1 inhibitor, C4-binding protein, factor H and factor I) in psoriasis. Ohkohchi K, etal., Tohoku J Exp Med. 1988 Apr;154(4):315-21.
31. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
32. Spontaneous hemolytic uremic syndrome triggered by complement factor H lacking surface recognition domains. Pickering MC, etal., J Exp Med. 2007 Jun 11;204(6):1249-56. Epub 2007 May 21.
33. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
34. Purification and characterization of human adrenomedullin binding protein-1. Qiang X, etal., Mol Med. 2008 Jul-Aug;14(7-8):443-50. doi: 10.2119/2008-00015.Qiang.
35. Immune complement and coagulation dysfunction in adverse outcomes of SARS-CoV-2 infection. Ramlall V, etal., Nat Med. 2020 Aug 3. pii: 10.1038/s41591-020-1021-2. doi: 10.1038/s41591-020-1021-2.
36. A rare penetrant mutation in CFH confers high risk of age-related macular degeneration. Raychaudhuri S, etal., Nat Genet. 2011 Oct 23;43(12):1232-6. doi: 10.1038/ng.976.
37. Isolation and Characterization of a Novel Rat Factor H-related Protein That Is Up-regulated in Glomeruli under Complement Attack. Ren G, etal., J Biol Chem 2002 Dec 13;277(50):48351-8.
38. Rat glomerular epithelial cells produce and bear factor H on their surface that is up-regulated under complement attack. Ren G, etal., Kidney Int. 2003 Sep;64(3):914-22.
39. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
40. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
41. Comprehensive gene review and curation RGD comprehensive gene curation
42. Complement factor H: a biomarker for progression of cutaneous squamous cell carcinoma. Riihila PM, etal., J Invest Dermatol. 2014 Feb;134(2):498-506. doi: 10.1038/jid.2013.346. Epub 2013 Aug 12.
43. Constitutive expression and regulation of rat complement factor H in primary cultures of hepatocytes, Kupffer cells, and two hepatoma cell lines. Schlaf G, etal., Lab Invest 2002 Feb;82(2):183-92.
44. Peripheral retinal drusen and reticular pigment: association with CFHY402H and CFHrs1410996 genotypes in family and twin studies. Seddon JM, etal., Invest Ophthalmol Vis Sci. 2009 Feb;50(2):586-91. doi: 10.1167/iovs.08-2514. Epub 2008 Oct 20.
45. Association of CFH Y402H and LOC387715 A69S with progression of age-related macular degeneration. Seddon JM, etal., JAMA. 2007 Apr 25;297(16):1793-800.
46. Distribution of immunoreactivity for the adrenomedullin binding protein, complement factor H, in the rat brain. Serrano J, etal., Neuroscience 2003;116(4):947-62.
47. Attenuation of renal ischemia and reperfusion injury by human adrenomedullin and its binding protein. Shah KG, etal., J Surg Res. 2010 Sep;163(1):110-7. doi: 10.1016/j.jss.2010.03.064. Epub 2010 Apr 24.
48. Fusion protein comprising factor H domains 6 and 7 and human IgG1 Fc as an antibacterial immunotherapeutic. Shaughnessy J, etal., Clin Vaccine Immunol. 2014 Oct;21(10):1452-9. doi: 10.1128/CVI.00444-14. Epub 2014 Aug 20.
49. Serum proteomics of methamphetamine addicts and up-regulation of complement factor H related to methamphetamine addiction. Shi WL, etal., Neurosci Lett. 2012 Sep 6;525(1):23-8. doi: 10.1016/j.neulet.2012.07.026. Epub 2012 Jul 31.
50. Y402H complement factor H polymorphism associated with exudative age-related macular degeneration in the French population. Souied EH, etal., Mol Vis. 2005 Dec 19;11:1135-40.
51. Oxidative stress and the regulation of complement activation in human glaucoma. Tezel G, etal., Invest Ophthalmol Vis Sci. 2010 Oct;51(10):5071-82. doi: 10.1167/iovs.10-5289. Epub 2010 May 19.
52. Association of complement factor H tyrosine 402 histidine genotype with posterior involvement in sarcoid-related uveitis. Thompson IA, etal., Am J Ophthalmol. 2013 Jun;155(6):1068-1074.e1. doi: 10.1016/j.ajo.2013.01.019. Epub 2013 Mar 14.
53. [Role of CFH and ARMS2 polymorphisms in retinopathy and coronary artery disease in type 1 diabetes]. Toni M, etal., An Sist Sanit Navar. 2012 Sep-Dec;35(3):425-32.
54. Clinical evaluation of 3 families with basal laminar drusen caused by novel mutations in the complement factor H gene. van de Ven JP, etal., Arch Ophthalmol. 2012 Aug;130(8):1038-47.
55. Complement Factor H Serum Levels Determine Resistance to Pneumococcal Invasive Disease. van der Maten E, etal., J Infect Dis. 2016 Jun 1;213(11):1820-7. doi: 10.1093/infdis/jiw029. Epub 2016 Jan 21.
56. Enhanced bacteremia in human factor H transgenic rats infected by Neisseria meningitidis. Vu DM, etal., Infect Immun. 2012 Feb;80(2):643-50. doi: 10.1128/IAI.05604-11. Epub 2011 Nov 21.
57. Association of CFH and CFB gene polymorphisms with retinopathy in type 2 diabetic patients. Wang J, etal., Mediators Inflamm. 2013;2013:748435. doi: 10.1155/2013/748435. Epub 2013 Jun 24.
58. Mechanisms responsible for vascular hyporesponsiveness to adrenomedullin after hemorrhage: the central role of adrenomedullin binding protein-1. Wu R, etal., Ann Surg. 2005 Jul;242(1):115-23.
59. Reversing established sepsis in rats with human vasoactive hormone adrenomedullin and its binding protein. Wu R, etal., Mol Med. 2009 Jan-Feb;15(1-2):28-33. doi: 10.2119/molmed.2008.00092. Epub 2008 Oct 10.
60. Human vasoactive hormone adrenomedullin and its binding protein rescue experimental animals from shock. Wu R, etal., Peptides. 2008 Jul;29(7):1223-30. doi: 10.1016/j.peptides.2008.02.021. Epub 2008 Mar 8.
61. Human adrenomedullin and its binding protein attenuate organ injury and reduce mortality after hepatic ischemia-reperfusion. Yang J, etal., Ann Surg. 2009 Feb;249(2):310-7. doi: 10.1097/SLA.0b013e3181961d43.
62. Human adrenomedullin and its binding protein ameliorate sepsis-induced organ injury and mortality in jaundiced rats. Yang J, etal., Peptides. 2010 May;31(5):872-7. doi: 10.1016/j.peptides.2010.01.010. Epub 2010 Feb 2.
63. Association of C2 and CFB polymorphisms with anterior uveitis. Yang MM, etal., Invest Ophthalmol Vis Sci. 2012 Jul 27;53(8):4969-74. doi: 10.1167/iovs.12-9478.
64. Complement factor H gene mutation associated with autosomal recessive atypical hemolytic uremic syndrome. Ying L, etal., Am J Hum Genet. 1999 Dec;65(6):1538-46.
65. Factor h and properdin recognize different epitopes on renal tubular epithelial heparan sulfate. Zaferani A, etal., J Biol Chem. 2012 Sep 7;287(37):31471-81. doi: 10.1074/jbc.M112.380386. Epub 2012 Jul 19.
66. Association of genetic variants in complement factor H and factor H-related genes with systemic lupus erythematosus susceptibility. Zhao J, etal., PLoS Genet. 2011 May;7(5):e1002079. Epub 2011 May 26.
Additional References at PubMed
PMID:12477932   PMID:12947022   PMID:15574507   PMID:16023208   PMID:16769899   PMID:17028856   PMID:17921253   PMID:18947875   PMID:19299737   PMID:19411110   PMID:19541934   PMID:19850925  
PMID:20675597   PMID:20702729   PMID:20813971   PMID:21148255   PMID:22471560   PMID:22516433   PMID:23487775   PMID:23533145   PMID:23844226   PMID:24006456   PMID:24835392   PMID:24929970  
PMID:25284781   PMID:25991857   PMID:26149919   PMID:26468283   PMID:27564415   PMID:28057640   PMID:28228282   PMID:29070671   PMID:29590637   PMID:30705315  


Genomics

Comparative Map Data
Cfh
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81354,063,079 - 54,164,523 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1354,062,531 - 54,164,532 (-)EnsemblGRCr8
mRatBN7.21351,512,376 - 51,613,829 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1351,511,828 - 51,613,838 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1354,104,450 - 54,199,522 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01355,392,371 - 55,487,454 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01352,655,305 - 52,757,017 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01356,979,155 - 57,080,540 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1356,978,607 - 57,080,622 (-)Ensemblrn6Rnor6.0
Rnor_5.01361,997,444 - 62,094,826 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41353,252,249 - 53,355,987 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1351,770,541 - 51,871,522 (-)NCBICelera
RGSC_v3.11353,266,346 - 53,370,041 (-)NCBI
Cytogenetic Map13q13NCBI
CFH
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381196,652,043 - 196,747,504 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1196,651,754 - 196,752,476 (+)Ensemblhg38GRCh38
GRCh371196,621,173 - 196,716,634 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361194,887,764 - 194,983,257 (+)NCBIBuild 36Build 36hg18NCBI36
Build 341193,352,831 - 193,448,257NCBI
Celera1169,729,995 - 169,825,611 (+)NCBICelera
Cytogenetic Map1q31.3NCBI
HuRef1167,862,965 - 167,958,566 (+)NCBIHuRef
CHM1_11198,042,727 - 198,138,292 (+)NCBICHM1_1
T2T-CHM13v2.01195,998,386 - 196,093,925 (+)NCBIT2T-CHM13v2.0
Cfh
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391140,013,593 - 140,111,149 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1140,012,446 - 140,111,502 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381140,085,855 - 140,183,411 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1140,084,708 - 140,183,764 (-)Ensemblmm10GRCm38
MGSCv371141,982,432 - 142,079,988 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361141,902,290 - 141,999,733 (-)NCBIMGSCv36mm8
Celera1142,720,865 - 142,812,024 (-)NCBICelera
Cytogenetic Map1FNCBI
cM Map161.62NCBI
CFH
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2153,056,725 - 53,152,308 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1152,576,787 - 52,757,831 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01172,155,882 - 172,251,632 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11176,434,107 - 176,507,049 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1176,455,247 - 176,525,521 (+)EnsemblpanPan2panpan1.1
CFH
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1382,878,677 - 2,956,226 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha382,970,756 - 3,047,389 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0382,876,209 - 2,953,077 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl382,875,485 - 2,953,035 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1382,869,120 - 2,945,692 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0383,262,568 - 3,340,656 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0383,463,162 - 3,540,549 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
CFH
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa10.21024,337,539 - 24,406,888 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CFH
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12532,557,697 - 32,744,763 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366605533,547,560 - 33,658,543 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Cfh
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247983,332,549 - 3,414,435 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Cfh
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11020,205,390 - 20,304,398 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Cfh
1451 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:524
Count of miRNA genes:165
Interacting mature miRNAs:188
Transcripts:ENSRNOT00000017749, ENSRNOT00000060111
Prediction methods:Microtar, Miranda
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1298066Bp159Blood pressure QTL 1590.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134863963493639634Rat
10755495Bp387Blood pressure QTL 3873.78arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)133721624190057603Rat
9589141Insul28Insulin level QTL 2810.820.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)131186625456866254Rat
1354655Bp241Blood pressure QTL 2413.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1338975045103588154Rat
70220Bp55Blood pressure QTL 555.75arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)133992469384924693Rat
71119Thym2Thymus enlargement QTL 23.8thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)134874981487285480Rat
61391Bp5Blood pressure QTL 55.6arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)132485392569853925Rat
4889861Pur29Proteinuria QTL 2913.80.005urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)133996821183286298Rat
2317040Aia21Adjuvant induced arthritis QTL 212.75joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)131238432057384320Rat
631645Bp121Blood pressure QTL 1213.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)131746828262468282Rat
2317046Aia8Adjuvant induced arthritis QTL 83.9700000286102295joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)131238432057384320Rat
619615Bp80Blood pressure QTL 800.0354arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)13742179187286911Rat
1331784Bp222Blood pressure QTL 2222.944arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)132433543255601132Rat
61340Bp25Blood pressure QTL 254.20.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)133708798382087983Rat
1581573Uae36Urinary albumin excretion QTL 36urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)13600200888706694Rat
1549897Stresp12Stress response QTL 123.35stress-related behavior trait (VT:0010451)number of approaches toward negative stimulus before onset of defensive burying response (CMO:0001960)134098358585983585Rat
724564Uae11Urinary albumin excretion QTL 115.7urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)134735425894285672Rat
7207885Glom27Glomerulus QTL 273.9kidney glomerulus integrity trait (VT:0010546)kidney crescentic glomeruli count to kidney normal glomeruli count ratio (CMO:0002139)1321120177109350286Rat
1558644Cm45Cardiac mass QTL 453.60.002heart mass (VT:0007028)heart wet weight (CMO:0000069)132624480871244808Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)133379409678794096Rat
61349Bp31Blood pressure QTL 315.75arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)133992469384924693Rat
2303563Bw89Body weight QTL 896body mass (VT:0001259)body weight (CMO:0000012)133483494779834947Rat
1354621Rf47Renal function QTL 473.7kidney renin amount (VT:0010559)kidney renin level (CMO:0002166)1311081740103588154Rat
2301962Cm72Cardiac mass QTL 724.12heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)133379409660914504Rat
1581554Pur11Proteinuria QTL 11urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)13600200888706694Rat
12879477Bp401Blood pressure QTL 401arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)133981472684814726Rat
1331750Bp220Blood pressure QTL 2202.98arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)133996821184968211Rat
6893338Cm76Cardiac mass QTL 7600.99heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)132624480871244808Rat
11530006Niddm72Non-insulin dependent diabetes mellitus QTL 720.001blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)133828629883286298Rat
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)131103588154Rat
9589164Gluco66Glucose level QTL 666.670.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)131771133662711336Rat
7411662Foco29Food consumption QTL 2920.80.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)131186625456866254Rat

Markers in Region
Cfh  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21351,595,293 - 51,595,835 (+)MAPPERmRatBN7.2
Rnor_6.01357,062,011 - 57,062,552NCBIRnor6.0
Rnor_5.01362,076,228 - 62,076,769UniSTSRnor5.0
RGSC_v3.41353,337,425 - 53,337,966UniSTSRGSC3.4
Celera1351,853,213 - 51,853,754UniSTS
Cytogenetic Map13q13UniSTS
RH130216  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21351,512,407 - 51,512,612 (+)MAPPERmRatBN7.2
Rnor_6.01356,979,187 - 56,979,391NCBIRnor6.0
Rnor_5.01361,997,476 - 61,997,680UniSTSRnor5.0
RGSC_v3.41353,252,281 - 53,252,485UniSTSRGSC3.4
Celera1351,770,573 - 51,770,777UniSTS
Cytogenetic Map13q13UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 65 161 91 90 59 92 59 6 354 190 11 140 81 92 31 13 13

Sequence


Ensembl Acc Id: ENSRNOT00000017749   ⟹   ENSRNOP00000017749
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1356,979,648 - 57,080,491 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000060111   ⟹   ENSRNOP00000056859
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1354,063,079 - 54,164,523 (-)Ensembl
mRatBN7.2 Ensembl1351,512,376 - 51,613,829 (-)Ensembl
Rnor_6.0 Ensembl1356,979,169 - 57,080,622 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000086572   ⟹   ENSRNOP00000072850
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1354,062,531 - 54,164,532 (-)Ensembl
mRatBN7.2 Ensembl1351,511,828 - 51,613,838 (-)Ensembl
Rnor_6.0 Ensembl1356,978,607 - 57,080,549 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000134445   ⟹   ENSRNOP00000100857
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1354,063,079 - 54,164,523 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000156729   ⟹   ENSRNOP00000106026
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1354,063,079 - 54,164,523 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000157491   ⟹   ENSRNOP00000106291
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1354,063,079 - 54,164,523 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000171353   ⟹   ENSRNOP00000103626
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1354,063,079 - 54,164,523 (-)Ensembl
RefSeq Acc Id: NM_130409   ⟹   NP_569093
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81354,063,079 - 54,164,523 (-)NCBI
mRatBN7.21351,512,376 - 51,613,829 (-)NCBI
Rnor_6.01356,979,155 - 57,080,540 (-)NCBI
Rnor_5.01361,997,444 - 62,094,826 (-)NCBI
RGSC_v3.41353,252,249 - 53,355,987 (-)RGD
Celera1351,770,541 - 51,871,522 (-)RGD
Sequence:
RefSeq Acc Id: NP_569093   ⟸   NM_130409
- Peptide Label: precursor
- UniProtKB: G3V9R2 (UniProtKB/TrEMBL),   Q91YB6 (UniProtKB/TrEMBL),   A6ICN2 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000072850   ⟸   ENSRNOT00000086572
Ensembl Acc Id: ENSRNOP00000056859   ⟸   ENSRNOT00000060111
Ensembl Acc Id: ENSRNOP00000017749   ⟸   ENSRNOT00000017749
Ensembl Acc Id: ENSRNOP00000100857   ⟸   ENSRNOT00000134445
Ensembl Acc Id: ENSRNOP00000106291   ⟸   ENSRNOT00000157491
Ensembl Acc Id: ENSRNOP00000103626   ⟸   ENSRNOT00000171353
Ensembl Acc Id: ENSRNOP00000106026   ⟸   ENSRNOT00000156729
Protein Domains
Sushi

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-G3V9R2-F1-model_v2 AlphaFold G3V9R2 1-1235 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13698882
Promoter ID:EPDNEW_R9394
Type:initiation region
Name:Cfh_1
Description:complement factor H
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01357,080,570 - 57,080,630EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620428 AgrOrtholog
BioCyc Gene G2FUF-18064 BioCyc
Ensembl Genes ENSRNOG00000030715 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000060111 ENTREZGENE
  ENSRNOT00000060111.6 UniProtKB/TrEMBL
  ENSRNOT00000086572.3 UniProtKB/TrEMBL
  ENSRNOT00000134445.1 UniProtKB/TrEMBL
  ENSRNOT00000156729.1 UniProtKB/TrEMBL
  ENSRNOT00000157491.1 UniProtKB/TrEMBL
  ENSRNOT00000171353.1 UniProtKB/TrEMBL
Gene3D-CATH Complement Module, domain 1 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7096787 IMAGE-MGC_LOAD
InterPro ComplSys_Reg/VirEntry_Med UniProtKB/TrEMBL
  Sushi/SCR/CCP_sf UniProtKB/TrEMBL
  Sushi_SCR_CCP UniProtKB/TrEMBL
KEGG Report rno:155012 UniProtKB/TrEMBL
MGC_CLONE MGC:91522 IMAGE-MGC_LOAD
NCBI Gene 155012 ENTREZGENE
PANTHER COMPLEMENT FACTOR H UniProtKB/TrEMBL
  COMPLEMENT FACTOR H-RELATED UniProtKB/TrEMBL
Pfam Sushi UniProtKB/TrEMBL
PhenoGen Cfh PhenoGen
PROSITE SUSHI UniProtKB/TrEMBL
RatGTEx ENSRNOG00000030715 RatGTEx
SMART CCP UniProtKB/TrEMBL
Superfamily-SCOP Complement_control_module UniProtKB/TrEMBL
UniProt A0ABK0KZJ3_RAT UniProtKB/TrEMBL
  A0ABK0LJD6_RAT UniProtKB/TrEMBL
  A0ABK0LMR3_RAT UniProtKB/TrEMBL
  A0ABK0LS19_RAT UniProtKB/TrEMBL
  A6ICN2 ENTREZGENE, UniProtKB/TrEMBL
  G3V9R2 ENTREZGENE, UniProtKB/TrEMBL
  Q5XJW6_RAT UniProtKB/TrEMBL
  Q91YB6 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-10-23 Cfh  complement factor H  Cfh  complement component factor H  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-01-20 Cfh  complement component factor H    complement component factor h  Name updated 1299863 APPROVED
2002-08-07 Cfh  complement component factor h      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_cellular_localization localized to the cytoplasm and nucleus 632369
gene_domains 11 short consensus repeats (SCRs); each SCR contains four characteristic cysteine residues 628500
gene_expression expressed in neurons of telencephalon, diencephalon, mesencephalon, pons, medulla, and cerebellum 632369
gene_expression expressed in glomerular epithelial cells, liver 628500
gene_function beta globulin 628500
gene_homology shows 24-79% homology to SCRs from human FHR-5 protein 628500
gene_physical_interaction binds to C3b 628500
gene_process may be involved in the decay of C3 convertase 628500
gene_process acts as a regulator of the activation of complement cascade 628500
gene_protein two N-linked glycosylation sites at positions 136 and 388 628500
gene_protein 76 kDa(predicted) 628500
gene_regulation may be induced as a response to glomerular injury 628500
gene_transcript 2729 bp long;568 bp long 3-UTR 628500