Adam15 (ADAM metallopeptidase domain 15) - Rat Genome Database

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Gene: Adam15 (ADAM metallopeptidase domain 15) Rattus norvegicus
Analyze
Symbol: Adam15
Name: ADAM metallopeptidase domain 15
RGD ID: 620402
Description: Predicted to enable SH3 domain binding activity; metalloendopeptidase activity; and signaling receptor binding activity. Involved in male gonad development; response to hypobaric hypoxia; and tissue regeneration. Predicted to be located in cell surface and extracellular exosome. Predicted to be active in extracellular space. Orthologous to human ADAM15 (ADAM metallopeptidase domain 15); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2-amino-2-deoxy-D-glucopyranose; 4,4'-sulfonyldiphenol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: a disintegrin and metallopeptidase domain 15 (metargidin); a disintegrin and metalloproteinase domain (ADAM) 15 (metargidin); a disintegrin and metalloproteinase domain 15; a disintegrin and metalloproteinase domain 15 (metargidin); ADAM 15; CRII-7; disintegrin and metalloproteinase domain-containing protein 15; MDC-15; MDC15; metalloprotease RGD disintegrin protein; metalloproteinase-like, disintegrin-like, and cysteine-rich protein 15; metargidin; tMDC VI; tMDCVI
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82177,052,363 - 177,062,879 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl2177,052,363 - 177,062,849 (-)EnsemblGRCr8
mRatBN7.22174,754,629 - 174,765,136 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2174,754,633 - 174,765,113 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx2181,899,637 - 181,910,172 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02179,922,013 - 179,932,548 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02174,522,552 - 174,533,074 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.02188,661,831 - 188,672,337 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2188,661,699 - 188,672,247 (-)Ensemblrn6Rnor6.0
Rnor_5.02208,071,874 - 208,082,531 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.42181,527,175 - 181,537,640 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera2168,696,199 - 168,706,661 (-)NCBICelera
RGSC_v3.12181,477,282 - 181,487,746 (-)NCBI
Cytogenetic Map2q34NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Integrin alpha5beta1 and ADAM-17 interact in vitro and co-localize in migrating HeLa cells. Bax DV, etal., J Biol Chem. 2004 May 21;279(21):22377-86. Epub 2004 Feb 16.
2. Homeostatic effects of the metalloproteinase disintegrin ADAM15 in degenerative cartilage remodeling. Bohm BB, etal., Arthritis Rheum. 2005 Apr;52(4):1100-9.
3. Cellular localization of the disintegrin CRII-7/rMDC15 mRNA in rat PNS and CNS and regulated expression in postnatal development and after nerve injury. Bosse F, etal., Glia 2000 Dec;32(3):313-27.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. Interaction of the metalloprotease disintegrins MDC9 and MDC15 with two SH3 domain-containing proteins, endophilin I and SH3PX1. Howard L, etal., J Biol Chem. 1999 Oct 29;274(44):31693-9.
6. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
7. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
8. GOA pipeline RGD automated data pipeline
9. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
10. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
11. Chronological gene expression of ADAMs during testicular development: prespermatogonia (gonocytes) express fertilin beta (ADAM2). Rosselot C, etal., Dev Dyn. 2003 Jul;227(3):458-67.
12. Differential expression of ADAM15 and ADAM17 metalloproteases in the rat brain after severe hypobaric hypoxia and hypoxic preconditioning. Rybnikova E, etal., Neurosci Res. 2012 Apr;72(4):364-73. doi: 10.1016/j.neures.2011.12.010. Epub 2012 Jan 2.
13. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
14. Increased expression of ADAM 9 and ADAM 15 mRNA in pancreatic cancer. Yamada D, etal., Anticancer Res. 2007 Mar-Apr;27(2):793-9.
Additional References at PubMed
PMID:9291465   PMID:12777399   PMID:19156209   PMID:22167186   PMID:22505472   PMID:24006456  


Genomics

Comparative Map Data
Adam15
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82177,052,363 - 177,062,879 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl2177,052,363 - 177,062,849 (-)EnsemblGRCr8
mRatBN7.22174,754,629 - 174,765,136 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2174,754,633 - 174,765,113 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx2181,899,637 - 181,910,172 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02179,922,013 - 179,932,548 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02174,522,552 - 174,533,074 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.02188,661,831 - 188,672,337 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2188,661,699 - 188,672,247 (-)Ensemblrn6Rnor6.0
Rnor_5.02208,071,874 - 208,082,531 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.42181,527,175 - 181,537,640 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera2168,696,199 - 168,706,661 (-)NCBICelera
RGSC_v3.12181,477,282 - 181,487,746 (-)NCBI
Cytogenetic Map2q34NCBI
ADAM15
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381155,051,316 - 155,062,775 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1155,050,566 - 155,062,780 (+)Ensemblhg38GRCh38
GRCh371155,023,792 - 155,035,251 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361153,290,386 - 153,301,876 (+)NCBIBuild 36Build 36hg18NCBI36
Build 341151,836,834 - 151,848,325NCBI
Celera1128,094,785 - 128,106,774 (+)NCBICelera
Cytogenetic Map1q21.3NCBI
HuRef1126,385,749 - 126,397,256 (+)NCBIHuRef
CHM1_11156,419,572 - 156,431,076 (+)NCBICHM1_1
T2T-CHM13v2.01154,190,701 - 154,202,162 (+)NCBIT2T-CHM13v2.0
Adam15
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39389,246,947 - 89,257,589 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl389,245,849 - 89,257,303 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38389,339,640 - 89,350,028 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl389,338,542 - 89,349,996 (-)Ensemblmm10GRCm38
MGSCv37389,143,562 - 89,153,932 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36389,424,469 - 89,435,909 (-)NCBIMGSCv36mm8
Celera389,374,683 - 89,385,053 (-)NCBICelera
Cytogenetic Map3F1NCBI
cM Map339.07NCBI
Adam15
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555451,545,635 - 1,555,614 (+)Ensembl
ChiLan1.0NW_0049555451,545,532 - 1,555,826 (+)NCBIChiLan1.0ChiLan1.0
ADAM15
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2194,778,158 - 94,789,698 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1194,510,197 - 94,521,712 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01130,398,961 - 130,410,860 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11134,008,959 - 134,020,467 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1134,008,959 - 134,020,467 (+)EnsemblpanPan2panpan1.1
ADAM15
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1742,432,067 - 42,443,463 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl742,428,113 - 42,443,429 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha741,923,026 - 41,933,600 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0742,301,837 - 42,312,428 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl742,301,842 - 42,312,494 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1742,081,565 - 42,092,138 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0742,135,440 - 42,145,971 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0742,418,961 - 42,429,316 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Adam15
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505825,557,826 - 25,568,277 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365804,588,039 - 4,599,014 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365804,588,182 - 4,598,659 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ADAM15
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl494,736,646 - 94,748,098 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1494,736,639 - 94,748,093 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.24103,518,254 - 103,529,683 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ADAM15
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1208,767,836 - 8,779,399 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl208,768,112 - 8,779,311 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_0236660388,102,189 - 8,113,704 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Adam15
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248852,441,217 - 2,451,057 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046248852,441,298 - 2,451,061 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Adam15
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1364,320,156 - 64,330,802 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Adam15
430 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:260
Count of miRNA genes:160
Interacting mature miRNAs:170
Transcripts:ENSRNOT00000027970, ENSRNOT00000050868
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1358356Srcrt1Stress Responsive Cort QTL13.66blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)2163997722225110681Rat
1578648Bss11Bone structure and strength QTL 114.7femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)2169358774214358774Rat
1331734Bp204Blood pressure QTL 2043.61192arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2170656145239614549Rat
631566Bp90Blood pressure QTL 900.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2149957381221199885Rat
1298074Bp164Blood pressure QTL 1640.003arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)244537979205135428Rat
1354648Bp239Blood pressure QTL 2390.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)267845370229470703Rat
1354649Kidm17Kidney mass QTL 172.9kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)283465462229820014Rat
10755499Bp389Blood pressure QTL 3892.61arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)220695736231474293Rat
1298076Bp166Blood pressure QTL 1660.0009arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2138595962205135428Rat
1581576Pur7Proteinuria QTL 70.0001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)280396178220931218Rat
61457Niddm8Non-insulin dependent diabetes mellitus QTL 84.10.01blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)2176840779178247591Rat
152025245Scl81Serum cholesterol level QTL 813.49blood cholesterol amount (VT:0000180)2124537199209621565Rat
1581578Cm49Cardiac mass QTL 494.90.01heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)2145807215220931416Rat
631198Cm22Cardiac mass QTL 224.30.0008heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)278269809208420281Rat
1554319Bmd2Bone mineral density QTL 213.40.0001lumbar vertebra area (VT:0010570)lumbar vertebra cross-sectional area (CMO:0001689)2122597372215234002Rat
12879836Kidm61Kidney mass QTL 610.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)2154723085199723085Rat
1581569Uae32Urinary albumin excretion QTL 320.0001urine protein amount (VT:0005160)urine albumin excretion rate (CMO:0000757)280396178220931218Rat
10043136Iddm54Insulin dependent diabetes mellitus QTL 543.40.0001blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)2145807215190807215Rat
12879837Am2Aortic mass QTL 20.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)2154723085199723085Rat
10043139Iddm55Insulin dependent diabetes mellitus QTL 553.10.0001blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)2150313808195313808Rat
12879838Cm86Cardiac mass QTL 860.002heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)2154723085199723085Rat
1302793Bw16Body weight QTL 1650.0001body mass (VT:0001259)body weight (CMO:0000012)2159440891205135267Rat
12879839Cm85Cardiac mass QTL 850.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)2154723085199723085Rat
1549833Bp257Blood pressure QTL 2570.003arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2170652929215652929Rat
1358900Bw48Body weight QTL 484.88body mass (VT:0001259)body weight (CMO:0000012)2159440891220931218Rat
4889834Pur24Proteinuria QTL 245.80.014urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)2171994826205135428Rat
12879845Cm89Cardiac mass QTL 890.008heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)2154723085178247591Rat
61473Bp19Blood pressure QTL 196.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2175008837178247591Rat
1359030Bp277Blood pressure QTL 277arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)2143565208188565208Rat
12879846Cm90Cardiac mass QTL 900.011heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)2154723085178247591Rat
12879847Am4Aortic mass QTL 40.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)2154723085178247591Rat
1331760Bp206Blood pressure QTL 2063.62454arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)24265106205135428Rat
12879840Bw179Body weight QTL 1790.005body mass (VT:0001259)body weight (CMO:0000012)2154723085199723085Rat
1581502Esta3Estrogen-induced thymic atrophy QTL 3thymus mass (VT:0004954)thymus wet weight (CMO:0000855)2139067258192287892Rat
1359032Hrtrt18Heart rate QTL 18heart pumping trait (VT:2000009)heart rate (CMO:0000002)2159440760195313808Rat
2301966Bp322Blood pressure QTL 3223.58arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2144882354205135428Rat
1298080Bp163Blood pressure QTL 1630.02arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)267845182205135428Rat
1357991Ael2Aortic elastin QTL 24.20.000071aorta elastin amount (VT:0003905)aortic elastin2169227906214227906Rat
8662832Vetf7Vascular elastic tissue fragility QTL 73.5aorta elastin amount (VT:0003905)aorta wall extracellular elastin dry weight to aorta wall dry weight ratio (CMO:0002002)283400752223709938Rat
1298085Bp165Blood pressure QTL 1650.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)244537979205135428Rat
1578671Bmd10Bone mineral density QTL 105.4femur mineral mass (VT:0010011)compact volumetric bone mineral density (CMO:0001730)2175931416220931416Rat
1359022Ppulsi1Prepulse inhibition QTL 13.63prepulse inhibition trait (VT:0003088)acoustic startle response measurement (CMO:0001519)2139067258184067258Rat
1641891Alcrsp17Alcohol response QTL 17response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)2151869660251712708Rat
724534Uae6Urinary albumin excretion QTL 610urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)280396034220931416Rat
61374Edpm2Estrogen-dependent pituitary mass QTL 24.420.86pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)278269809205135428Rat
8662843Vetf9Vascular elastic tissue fragility QTL 92.05thoracic aorta molecular composition trait (VT:0010568)aorta wall extracellular elastin dry weight to aorta wall extracellular collagen weight ratio (CMO:0002003)2159440760228950743Rat
2301415Cm67Cardiac mass QTL 670.003heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)2154723085178247591Rat
1331794Bp202Blood pressure QTL 2023.66819arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2143344967251712708Rat
71113Cari2Carrageenan-induced inflammation QTL 22.70.009hypodermis integrity trait (VT:0010550)inflammatory exudate volume (CMO:0001429)2143746578205135428Rat
1331805Cm29Cardiac mass QTL 293.50746heart mass (VT:0007028)heart wet weight (CMO:0000069)2143344967251712708Rat
11565180Kidm56Kidney mass QTL 560.003kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)2154723085178247591Rat
634308Sach6Saccharin preference QTL 64.9taste sensitivity trait (VT:0001986)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)2114384617215381366Rat
1598805Memor8Memory QTL 83exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)2150096616195096616Rat
11565181Bw176Body weight QTL 1760.002body mass (VT:0001259)body weight (CMO:0000012)2154723085178247591Rat
1358917Cm42Cardiac mass QTL 422.82heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)227148328206613235Rat
724568Uae13Urinary albumin excretion QTL 134.4urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)2145306936212705578Rat
1358913Cm41Cardiac mass QTL 412.73heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)227148328206613235Rat
1300165Rf9Renal function QTL 93.28kidney glomerulus integrity trait (VT:0010546)index of glomerular damage (CMO:0001135)2113746222205135428Rat
61401Niddm2Non-insulin dependent diabetes mellitus QTL 24.54blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)2147287892192287892Rat
631507Bp105Blood pressure QTL 1050.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2114384617215381366Rat
1641925Alcrsp2Alcohol response QTL 2response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)2151869660223841096Rat
1354609Niddm62Non-insulin dependent diabetes mellitus QTL 624.720.000006insulin secretion trait (VT:0003564)plasma insulin level (CMO:0000342)2117415288205135428Rat
1598833Bp295Blood pressure QTL 2953.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2150096616195096616Rat
1354622Kidm16Kidney mass QTL 163kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)283465462225110681Rat
631266Bp132Blood pressure QTL 1320.0005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)247856345205135428Rat
631522Bp74Blood pressure QTL 740.05arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2175008837220008837Rat
7488927Bp365Blood pressure QTL 3650.008arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2165453811210453811Rat
7488925Bp364Blood pressure QTL 3640.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2163253030208253030Rat
2293843Kiddil6Kidney dilation QTL 63.1kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)244537979184731399Rat
2306901Bp337Blood pressure QTL 3370.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2166372086229820014Rat
1354605Rf48Renal function QTL 482.9blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)276328396209350714Rat
7488904Bp363Blood pressure QTL 3630.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2175279960178247591Rat

Markers in Region
RH135252  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22174,760,548 - 174,760,742 (+)MAPPERmRatBN7.2
Rnor_6.02188,667,749 - 188,667,942NCBIRnor6.0
Rnor_5.02208,077,790 - 208,077,983UniSTSRnor5.0
RGSC_v3.42181,533,091 - 181,533,284UniSTSRGSC3.4
Celera2168,702,118 - 168,702,311UniSTS
RH 3.4 Map21155.9UniSTS
Cytogenetic Map2q34UniSTS
RH139781  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22174,754,659 - 174,754,849 (+)MAPPERmRatBN7.2
Rnor_6.02188,661,860 - 188,662,049NCBIRnor6.0
Rnor_5.02208,071,901 - 208,072,090UniSTSRnor5.0
RGSC_v3.42181,527,202 - 181,527,391UniSTSRGSC3.4
Celera2168,696,226 - 168,696,415UniSTS
RH 3.4 Map21156.4UniSTS
Cytogenetic Map2q34UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 162 91 90 59 92 59 6 356 192 11 141 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000027970   ⟹   ENSRNOP00000027970
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl2177,052,363 - 177,062,849 (-)Ensembl
mRatBN7.2 Ensembl2174,754,635 - 174,765,098 (-)Ensembl
Rnor_6.0 Ensembl2188,661,699 - 188,672,226 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000050868   ⟹   ENSRNOP00000039351
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl2177,052,363 - 177,062,849 (-)Ensembl
mRatBN7.2 Ensembl2174,754,665 - 174,765,088 (-)Ensembl
Rnor_6.0 Ensembl2188,661,835 - 188,672,247 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000105677   ⟹   ENSRNOP00000091249
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl2177,052,363 - 177,062,849 (-)Ensembl
mRatBN7.2 Ensembl2174,754,633 - 174,765,113 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000125476   ⟹   ENSRNOP00000100663
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl2177,052,363 - 177,062,849 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000167246   ⟹   ENSRNOP00000109701
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl2177,053,132 - 177,062,849 (-)Ensembl
RefSeq Acc Id: NM_001399128   ⟹   NP_001386057
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82177,052,363 - 177,062,849 (-)NCBI
mRatBN7.22174,754,629 - 174,765,116 (-)NCBI
RefSeq Acc Id: NM_001399129   ⟹   NP_001386058
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82177,052,363 - 177,062,849 (-)NCBI
mRatBN7.22174,754,629 - 174,765,116 (-)NCBI
RefSeq Acc Id: NM_020308   ⟹   NP_064704
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82177,052,363 - 177,062,849 (-)NCBI
mRatBN7.22174,754,629 - 174,765,116 (-)NCBI
Rnor_6.02188,661,833 - 188,672,297 (-)NCBI
Rnor_5.02208,071,874 - 208,082,531 (-)NCBI
RGSC_v3.42181,527,175 - 181,537,640 (-)RGD
Celera2168,696,199 - 168,706,661 (-)RGD
Sequence:
RefSeq Acc Id: XM_006232744   ⟹   XP_006232806
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82177,052,365 - 177,062,865 (-)NCBI
mRatBN7.22174,754,631 - 174,765,136 (-)NCBI
Rnor_6.02188,661,831 - 188,672,337 (-)NCBI
Rnor_5.02208,071,874 - 208,082,531 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008761203   ⟹   XP_008759425
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82177,052,365 - 177,062,879 (-)NCBI
mRatBN7.22174,754,631 - 174,765,136 (-)NCBI
Rnor_6.02188,661,831 - 188,672,337 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008761204   ⟹   XP_008759426
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82177,052,365 - 177,062,865 (-)NCBI
mRatBN7.22174,754,631 - 174,765,136 (-)NCBI
Rnor_6.02188,661,831 - 188,672,337 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017591056   ⟹   XP_017446545
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82177,053,217 - 177,062,866 (-)NCBI
mRatBN7.22174,755,487 - 174,765,136 (-)NCBI
Rnor_6.02188,662,680 - 188,672,337 (-)NCBI
Sequence:
RefSeq Acc Id: XM_063282423   ⟹   XP_063138493
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82177,053,184 - 177,062,866 (-)NCBI
RefSeq Acc Id: NP_064704   ⟸   NM_020308
- Peptide Label: isoform 3 precursor
- UniProtKB: A6J6F0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006232806   ⟸   XM_006232744
- Peptide Label: isoform X4
- UniProtKB: A0A8I6AF83 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008759426   ⟸   XM_008761204
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_008759425   ⟸   XM_008761203
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_017446545   ⟸   XM_017591056
- Peptide Label: isoform X2
- Sequence:
Ensembl Acc Id: ENSRNOP00000027970   ⟸   ENSRNOT00000027970
Ensembl Acc Id: ENSRNOP00000039351   ⟸   ENSRNOT00000050868
Ensembl Acc Id: ENSRNOP00000091249   ⟸   ENSRNOT00000105677
RefSeq Acc Id: NP_001386057   ⟸   NM_001399128
- Peptide Label: isoform 1 precursor
- UniProtKB: Q9QYV0 (UniProtKB/Swiss-Prot),   Q6P779 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: NP_001386058   ⟸   NM_001399129
- Peptide Label: isoform 2 precursor
RefSeq Acc Id: XP_063138493   ⟸   XM_063282423
- Peptide Label: isoform X5
Ensembl Acc Id: ENSRNOP00000100663   ⟸   ENSRNOT00000125476
Ensembl Acc Id: ENSRNOP00000109701   ⟸   ENSRNOT00000167246
Protein Domains
Disintegrin   EGF-like   Peptidase M12B

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9QYV0-F1-model_v2 AlphaFold Q9QYV0 1-864 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13691486
Promoter ID:EPDNEW_R1996
Type:initiation region
Name:Adam15_1
Description:ADAM metallopeptidase domain 15
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.02188,672,315 - 188,672,375EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620402 AgrOrtholog
BioCyc Gene G2FUF-52412 BioCyc
Ensembl Genes ENSRNOG00000020590 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000027970 ENTREZGENE
  ENSRNOT00000027970.5 UniProtKB/Swiss-Prot
  ENSRNOT00000050868 ENTREZGENE
  ENSRNOT00000050868.5 UniProtKB/Swiss-Prot
  ENSRNOT00000105677 ENTREZGENE
  ENSRNOT00000125476 ENTREZGENE
  ENSRNOT00000167246 ENTREZGENE
Gene3D-CATH 3.40.390.10 UniProtKB/Swiss-Prot
  4.10.70.10 UniProtKB/Swiss-Prot
  Galactose-binding domain-like UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:5597908 IMAGE-MGC_LOAD
InterPro ADAM_Cys-rich UniProtKB/Swiss-Prot
  Disintegrin_dom UniProtKB/Swiss-Prot
  Disintegrin_dom_sf UniProtKB/Swiss-Prot
  EGF-like_dom UniProtKB/Swiss-Prot
  MetalloPept_cat_dom_sf UniProtKB/Swiss-Prot
  Peptidase_M12B UniProtKB/Swiss-Prot
  Peptidase_M12B_N UniProtKB/Swiss-Prot
  Reprolysin_adamalysin UniProtKB/Swiss-Prot
KEGG Report rno:57025 UniProtKB/Swiss-Prot
MGC_CLONE MGC:72471 IMAGE-MGC_LOAD
NCBI Gene 57025 ENTREZGENE
PANTHER ADAM A DISINTEGRIN AND METALLOPROTEASE DOMAIN UniProtKB/Swiss-Prot
  PTHR11905:SF130 UniProtKB/Swiss-Prot
Pfam ADAM_CR UniProtKB/Swiss-Prot
  Disintegrin UniProtKB/Swiss-Prot
  Pep_M12B_propep UniProtKB/Swiss-Prot
  Reprolysin UniProtKB/Swiss-Prot
PhenoGen Adam15 PhenoGen
PROSITE ADAM_MEPRO UniProtKB/Swiss-Prot
  DISINTEGRIN_2 UniProtKB/Swiss-Prot
  EGF_2 UniProtKB/Swiss-Prot
  EGF_3 UniProtKB/Swiss-Prot
  ZINC_PROTEASE UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000020590 RatGTEx
SMART ACR UniProtKB/Swiss-Prot
  DISIN UniProtKB/Swiss-Prot
Superfamily-SCOP Metalloproteases ('zincins'), catalytic domain UniProtKB/Swiss-Prot
  SSF57552 UniProtKB/Swiss-Prot
UniProt A0A8I6AF83 ENTREZGENE, UniProtKB/TrEMBL
  A0ABK0LBJ4_RAT UniProtKB/TrEMBL
  A0ABK0M3R3_RAT UniProtKB/TrEMBL
  A6J6F0 ENTREZGENE, UniProtKB/TrEMBL
  ADA15_RAT UniProtKB/Swiss-Prot
  Q6P779 ENTREZGENE
  Q9QYV0 ENTREZGENE
UniProt Secondary Q6P779 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-02-21 Adam15  ADAM metallopeptidase domain 15  Adam15  a disintegrin and metallopeptidase domain 15 (metargidin)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-30 Adam15  a disintegrin and metallopeptidase domain 15 (metargidin)    a disintegrin and metalloproteinase domain 15 (metargidin)  Name updated 1299863 APPROVED
2004-09-10 Adam15  a disintegrin and metalloproteinase domain 15 (metargidin)    a disintegrin and metalloproteinase domain (ADAM) 15 (metargidin)  Name updated 1299863 APPROVED
2002-08-07 Adam15  a disintegrin and metalloproteinase domain (ADAM) 15 (metargidin)      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_domains contains a disintegrin and a metalloprotease domain 632016
gene_expression expressed in Schwann cells, brain, spinal cord and endothelial cells of peripheral nerve 632016
gene_expression differentially expressed during Wallerian degeneration and nerve regeneration 632016
gene_protein 85 kDa 632016