Rasgrf1 (RAS protein-specific guanine nucleotide-releasing factor 1) - Rat Genome Database

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Gene: Rasgrf1 (RAS protein-specific guanine nucleotide-releasing factor 1) Rattus norvegicus
Analyze
Symbol: Rasgrf1
Name: RAS protein-specific guanine nucleotide-releasing factor 1
RGD ID: 620395
Description: Enables receptor tyrosine kinase binding activity and small GTPase binding activity. Involved in several processes, including cellular response to insulin stimulus; modulation of chemical synaptic transmission; and positive regulation of Ras protein signal transduction. Located in several cellular components, including apical dendrite; apicolateral plasma membrane; and basolateral plasma membrane. Is active in glutamatergic synapse and postsynapse. Orthologous to human RASGRF1 (Ras protein specific guanine nucleotide releasing factor 1); PARTICIPATES IN mitogen activated protein kinase signaling pathway; INTERACTS WITH 1,2-dimethylhydrazine; 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: GNRP; guanine nucleotide-releasing protein; P140 RAS-GRF; ras-GRF1; ras-specific guanine nucleotide-releasing factor 1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8899,324,986 - 99,454,099 (+)NCBIGRCr8
mRatBN7.2890,445,154 - 90,574,274 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl890,445,154 - 90,574,269 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx896,124,511 - 96,254,135 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0894,323,932 - 94,453,555 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0892,167,140 - 92,296,111 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0897,277,250 - 97,405,095 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl897,277,456 - 97,405,102 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0896,778,440 - 96,905,934 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4894,802,467 - 94,811,501 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1894,955,729 - 94,955,978 (+)NCBI
Celera889,989,217 - 90,117,860 (+)NCBICelera
Cytogenetic Map8q31NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Ras-specific exchange factor GRF: oligomerization through its Dbl homology domain and calcium-dependent activation of Raf. Anborgh PH, etal., Mol Cell Biol. 1999 Jul;19(7):4611-22.
2. SCLIP, a microtubule-destabilizing factor, interacts with RasGRF1 and inhibits its ability to promote Rac activation and neurite outgrowth. Baldassa S, etal., J Biol Chem. 2007 Jan 26;282(4):2333-45. Epub 2006 Nov 29.
3. Inhibition of Ras-guanine nucleotide-releasing factor 1 (Ras-GRF1) signaling in the striatum reverts motor symptoms associated with L-dopa-induced dyskinesia. Fasano S, etal., Proc Natl Acad Sci U S A. 2010 Dec 14;107(50):21824-9. doi: 10.1073/pnas.1012071107. Epub 2010 Nov 29.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
6. The NMDA receptor is coupled to the ERK pathway by a direct interaction between NR2B and RasGRF1. Krapivinsky G, etal., Neuron. 2003 Nov 13;40(4):775-84.
7. p75-Ras-GRF1 is a c-Jun/AP-1 target protein: its up regulation results in increased Ras activity and is necessary for c-Jun-induced nonadherent growth of Rat1a cells. Leaner VD, etal., Mol Cell Biol. 2005 Apr;25(8):3324-37.
8. Requirement for Plk2 in orchestrated ras and rap signaling, homeostatic structural plasticity, and memory. Lee KJ, etal., Neuron. 2011 Mar 10;69(5):957-73. doi: 10.1016/j.neuron.2011.02.004.
9. Activity-dependent interaction of the intracellular domain of rat trkA with intermediate filament proteins, the beta-6 proteasomal subunit, Ras-GRF1, and the p162 subunit of eIF3. MacDonald JI, etal., J Mol Neurosci. 1999 Aug-Oct;13(1-2):141-58.
10. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
11. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
12. Association between ZIC2, RASGRF1, and SHISA6 genes and high myopia in Japanese subjects. Oishi M, etal., Invest Ophthalmol Vis Sci. 2013 Nov 13;54(12):7492-7. doi: 10.1167/iovs.13-12825.
13. Amphetamine alters Ras-guanine nucleotide-releasing factor expression in the rat striatum in vivo. Parelkar NK, etal., Eur J Pharmacol. 2009 Oct 1;619(1-3):50-6. doi: 10.1016/j.ejphar.2009.08.006. Epub 2009 Aug 14.
14. A direct repeat sequence at the Rasgrf1 locus and imprinted expression. Pearsall RS, etal., Genomics 1999 Jan 15;55(2):194-201.
15. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
16. GOA pipeline RGD automated data pipeline
17. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
18. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
19. Molecular cloning of cDNAs encoding a guanine-nucleotide-releasing factor for Ras p21. Shou C, etal., Nature. 1992 Jul 23;358(6384):351-4.
20. A 54-kDa protein related to ras-guanine nucleotide release factor expressed in the rat exocrine pancreas. Tung PS, etal., Cell Tissue Res. 1997 Sep;289(3):505-15.
21. Phosphorylation of the Ras-GRF1 exchange factor at Ser916/898 reveals activation of Ras signaling in the cerebral cortex. Yang H, etal., J Biol Chem. 2003 Apr 11;278(15):13278-85. Epub 2003 Jan 21.
22. Decreased expression of Ras-GRF1 in the brain tissue of the intractable epilepsy patients and experimental rats. Zhu Q, etal., Brain Res. 2013 Feb 1;1493:99-109. doi: 10.1016/j.brainres.2012.11.033. Epub 2012 Nov 27.
23. Hypoinsulinemia alleviates the GRF1/Ras/Akt anti-apoptotic pathway and induces alterations of mitochondrial ras trafficking in neuronal cells. Zhuravliova E, etal., Neurochem Res. 2009 Jun;34(6):1076-82. doi: 10.1007/s11064-008-9877-4. Epub 2008 Nov 11.
Additional References at PubMed
PMID:8889548   PMID:11749043   PMID:12024021   PMID:12477932   PMID:12805218   PMID:14749369   PMID:15029245   PMID:16710293   PMID:17931779   PMID:19446794   PMID:20107120   PMID:22871113  
PMID:25644714   PMID:26890742   PMID:27856453   PMID:30053369   PMID:31245854  


Genomics

Comparative Map Data
Rasgrf1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8899,324,986 - 99,454,099 (+)NCBIGRCr8
mRatBN7.2890,445,154 - 90,574,274 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl890,445,154 - 90,574,269 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx896,124,511 - 96,254,135 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0894,323,932 - 94,453,555 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0892,167,140 - 92,296,111 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0897,277,250 - 97,405,095 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl897,277,456 - 97,405,102 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0896,778,440 - 96,905,934 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4894,802,467 - 94,811,501 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1894,955,729 - 94,955,978 (+)NCBI
Celera889,989,217 - 90,117,860 (+)NCBICelera
Cytogenetic Map8q31NCBI
RASGRF1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381578,959,906 - 79,090,780 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1578,959,906 - 79,090,780 (-)EnsemblGRCh38hg38GRCh38
GRCh371579,252,248 - 79,383,122 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361577,041,341 - 77,169,895 (-)NCBINCBI36Build 36hg18NCBI36
Build 341577,041,340 - 77,085,057NCBI
Celera1556,188,621 - 56,319,894 (-)NCBICelera
Cytogenetic Map15q25.1NCBI
HuRef1556,012,219 - 56,142,688 (-)NCBIHuRef
CHM1_11579,370,538 - 79,501,430 (-)NCBICHM1_1
T2T-CHM13v2.01576,823,565 - 76,954,487 (-)NCBIT2T-CHM13v2.0
Rasgrf1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39989,791,565 - 89,909,032 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl989,791,961 - 89,909,030 (+)EnsemblGRCm39 Ensembl
GRCm38989,909,508 - 90,026,979 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl989,909,908 - 90,026,977 (+)EnsemblGRCm38mm10GRCm38
MGSCv37989,804,613 - 89,921,817 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36989,707,668 - 89,827,694 (+)NCBIMGSCv36mm8
Celera989,525,851 - 89,642,271 (+)NCBICelera
Cytogenetic Map9E3.1NCBI
cM Map947.31NCBI
Rasgrf1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495553370,897 - 167,460 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495553369,736 - 167,626 (-)NCBIChiLan1.0ChiLan1.0
RASGRF1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21668,218,024 - 68,348,582 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11572,383,681 - 72,514,345 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01557,933,152 - 58,063,824 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11576,891,556 - 77,022,437 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1576,891,556 - 77,022,534 (-)Ensemblpanpan1.1panPan2
RASGRF1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1357,995,092 - 58,085,395 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl357,995,786 - 58,085,380 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha360,655,204 - 60,748,389 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0358,431,317 - 58,524,707 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl358,431,335 - 58,524,707 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1357,928,254 - 58,021,585 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0358,136,616 - 58,229,853 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0358,484,151 - 58,578,346 (+)NCBIUU_Cfam_GSD_1.0
Rasgrf1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640119,325,532 - 119,429,648 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647137,171,297 - 37,278,529 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647137,173,595 - 37,278,356 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
RASGRF1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl748,121,419 - 48,246,749 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1748,121,415 - 48,246,749 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2753,659,631 - 53,785,342 (-)NCBISscrofa10.2Sscrofa10.2susScr3
RASGRF1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1264,298,091 - 4,431,606 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl264,299,116 - 4,432,420 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666048137,418,910 - 137,548,979 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Rasgrf1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624941110,676 - 222,092 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624941110,752 - 222,143 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Rasgrf1
652 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:480
Count of miRNA genes:218
Interacting mature miRNAs:253
Transcripts:ENSRNOT00000018702, ENSRNOT00000018794
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1581557Eae16Experimental allergic encephalomyelitis QTL 163.8nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)88462195110921472Rat
631650Stl6Serum triglyceride level QTL 640.0019blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)810378157112202585Rat
731182Uae24Urinary albumin excretion QTL 246.4urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)81933115293965294Rat
1358892Kidm26Kidney mass QTL 263.69kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)82720571599103503Rat
1358896Bp262Blood pressure QTL 2622.89arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)82720571599103503Rat
1358907Cm40Cardiac mass QTL 401.89heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)82720571599103503Rat
8662823Vetf5Vascular elastic tissue fragility QTL 51.9artery integrity trait (VT:0010639)patent ductus arteriosus score (CMO:0002566)82824291299525068Rat
1549908Neudeg1Neurodegradation QTL 15.50nervous system integrity trait (VT:0010566)logarithm of the ratio of the lesioned side motor neuron count to contralateral side motor neuron count (CMO:0001986)83018886794457446Rat
1578755Pur5Proteinuria QTL 53.30.0001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)830848154101699754Rat
1578765Klgr1Kidney lesion grade QTL 13.30.0001kidney morphology trait (VT:0002135)organ lesion measurement (CMO:0000677)830848154101699754Rat
1578769Uae31Urinary albumin excretion QTL 313.30.001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)830848154101699754Rat
2316950Scl66Serum cholesterol level QTL 664.1blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)830848259105647037Rat
1331838Niddm61Non-insulin dependent diabetes mellitus QTL 613.530.0004blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)83646953599083736Rat
1358906Bp253Blood pressure QTL 25340.0004arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)84071306693965294Rat
1554321Bmd3Bone mineral density QTL 37.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)840952565123900184Rat
12879882Am8Aortic mass QTL 80.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)84329616998968765Rat
12879878Bw183Body weight QTL 1830.001body mass (VT:0001259)body weight (CMO:0000012)84329616998968765Rat
12879879Cm99Cardiac mass QTL 990.001heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)84329616998968765Rat
12879880Cm100Cardiac mass QTL 1000.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)84329616998968765Rat
12879881Cm101Cardiac mass QTL 1010.001heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)84329616998968765Rat
12879883Kidm65Kidney mass QTL 650.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)84329616998968765Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)846531639119088626Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)846531639119088626Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)absolute change in systolic blood pressure (CMO:0000607)846531639119088626Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)846531639119088626Rat
1331837Bw23Body weight QTL 234.190.00007body mass (VT:0001259)body weight (CMO:0000012)84653172299083736Rat
2303570Gluco48Glucose level QTL 482blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)84980583194805831Rat
1358912Bw51Body weight QTL 512.95body mass (VT:0001259)body weight (CMO:0000012)851351728107062046Rat
10402857Bp380Blood pressure QTL 3800.95arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)85396876598968765Rat
2301402Bp316Blood pressure QTL 3160.005arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)85396876598968765Rat
2293697Bmd39Bone mineral density QTL 39femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)85404374498968765Rat
631664Hcar3Hepatocarcinoma resistance QTL 32.90.0005liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)85423764499103503Rat
1300177Cm2Cardiac mass QTL 23.65heart mass (VT:0007028)heart weight (CMO:0000017)854259986100382532Rat
2303171Bp331Blood pressure QTL 3315.570.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)861290298119084929Rat
631653Bp125Blood pressure QTL 1253.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)866142385111142385Rat
631210Bw3Body weight QTL35.9mesenteric fat pad mass (VT:0010427)mesenteric fat pad weight to body weight ratio (CMO:0000654)869349194112783834Rat
1300171Bp184Blood pressure QTL 1843.66arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)870513503118219066Rat
8694446Bw170Body weight QTL 17012.070.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)871888757116888757Rat
9590292Uminl3Urine mineral level QTL 33.620.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)871888757116888757Rat
8694200Abfw4Abdominal fat weight QTL 49.070.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)871888757116888757Rat
8694392Bw161Body weight QTL 1618.060.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)871888757116888757Rat
1549909Stresp11Stress response QTL 116.830.0019stress-related behavior trait (VT:0010451)number of approaches toward negative stimulus before onset of defensive burying response (CMO:0001960)873473045118473045Rat
2300181Bmd55Bone mineral density QTL 555.70.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)876468691121468691Rat
61437Cia6Collagen induced arthritis QTL 6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)882460758122812818Rat
2313400Anxrr25Anxiety related response QTL 25aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)889265192114019816Rat

Markers in Region
D8Rat20  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2890,508,442 - 90,508,589 (+)MAPPERmRatBN7.2
Rnor_6.0897,339,298 - 97,339,444NCBIRnor6.0
Rnor_5.0896,840,137 - 96,840,283UniSTSRnor5.0
RGSC_v3.4894,870,172 - 94,870,319RGDRGSC3.4
RGSC_v3.4894,870,173 - 94,870,319UniSTSRGSC3.4
RGSC_v3.1894,889,628 - 94,889,774RGD
Celera890,052,436 - 90,052,582UniSTS
RH 3.4 Map81013.3RGD
RH 3.4 Map81013.3UniSTS
RH 2.0 Map8792.0RGD
SHRSP x BN Map852.75RGD
Cytogenetic Map8q31UniSTS
D8Got142  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2890,568,562 - 90,568,797 (+)MAPPERmRatBN7.2
Rnor_6.0897,399,384 - 97,399,618NCBIRnor6.0
Rnor_5.0896,900,223 - 96,900,457UniSTSRnor5.0
RGSC_v3.4894,930,960 - 94,931,195RGDRGSC3.4
RGSC_v3.4894,930,961 - 94,931,195UniSTSRGSC3.4
RGSC_v3.1894,950,416 - 94,950,650RGD
Celera890,112,168 - 90,112,396UniSTS
RH 3.4 Map81013.6UniSTS
RH 3.4 Map81013.6RGD
RH 2.0 Map8788.4RGD
Cytogenetic Map8q31UniSTS
D8Got309  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2890,529,607 - 90,529,705 (+)MAPPERmRatBN7.2
Rnor_6.0897,360,499 - 97,360,596NCBIRnor6.0
Rnor_5.0896,861,338 - 96,861,435UniSTSRnor5.0
RGSC_v3.4894,891,335 - 94,891,432UniSTSRGSC3.4
Celera890,073,494 - 90,073,585UniSTS
Cytogenetic Map8q31UniSTS
RH132198  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2890,451,928 - 90,452,125 (+)MAPPERmRatBN7.2
Rnor_6.0897,284,181 - 97,284,377NCBIRnor6.0
Rnor_5.0896,785,020 - 96,785,216UniSTSRnor5.0
RGSC_v3.4894,810,623 - 94,810,819UniSTSRGSC3.4
Celera889,995,984 - 89,996,180UniSTS
RH 3.4 Map81013.6UniSTS
Cytogenetic Map8q31UniSTS
RH133787  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2890,573,916 - 90,574,127 (+)MAPPERmRatBN7.2
Rnor_6.0897,404,738 - 97,404,948NCBIRnor6.0
Rnor_5.0896,905,577 - 96,905,787UniSTSRnor5.0
RGSC_v3.4894,936,315 - 94,936,525UniSTSRGSC3.4
Celera890,117,503 - 90,117,713UniSTS
RH 3.4 Map81013.3UniSTS
Cytogenetic Map8q31UniSTS
AU046538  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2890,444,761 - 90,444,897 (+)MAPPERmRatBN7.2
Rnor_6.0897,276,860 - 97,276,993NCBIRnor6.0
Rnor_5.0896,778,050 - 96,778,183UniSTSRnor5.0
RGSC_v3.4894,802,077 - 94,802,210UniSTSRGSC3.4
Celera889,988,827 - 89,988,960UniSTS
Cytogenetic Map8q31UniSTS
AU049054  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2890,456,224 - 90,456,426 (+)MAPPERmRatBN7.2
Rnor_6.0897,288,476 - 97,288,677NCBIRnor6.0
Rnor_5.0896,789,315 - 96,789,516UniSTSRnor5.0
RGSC_v3.4894,814,918 - 94,815,119UniSTSRGSC3.4
Celera890,000,279 - 90,000,480UniSTS
Cytogenetic Map8q31UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 54
Low 8 2 2 10 23 1 2
Below cutoff 2 16 16 8 15 8 6 6 8 6 11 10 6

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000018794   ⟹   ENSRNOP00000018794
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl890,445,230 - 90,574,269 (+)Ensembl
Rnor_6.0 Ensembl897,291,580 - 97,405,102 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000082757   ⟹   ENSRNOP00000070883
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl890,445,230 - 90,564,900 (+)Ensembl
Rnor_6.0 Ensembl897,277,456 - 97,404,768 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000094519   ⟹   ENSRNOP00000090813
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl890,445,154 - 90,446,959 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000106070   ⟹   ENSRNOP00000077058
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl890,445,154 - 90,452,807 (+)Ensembl
RefSeq Acc Id: NM_001105753   ⟹   NP_001099223
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8899,324,986 - 99,332,636 (+)NCBI
mRatBN7.2890,445,154 - 90,452,807 (+)NCBI
Rnor_6.0897,277,250 - 97,285,059 (+)NCBI
Rnor_5.0896,778,440 - 96,905,934 (+)NCBI
RGSC_v3.4894,802,467 - 94,811,501 (+)RGD
Celera889,989,217 - 89,996,862 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001170531   ⟹   NP_001164002
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8899,325,062 - 99,454,099 (+)NCBI
mRatBN7.2890,445,230 - 90,574,274 (+)NCBI
Rnor_6.0897,277,326 - 97,405,095 (+)NCBI
Rnor_5.0896,778,440 - 96,905,934 (+)NCBI
Celera889,989,293 - 90,117,860 (+)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_001099223   ⟸   NM_001105753
- Peptide Label: isoform 2
- UniProtKB: A0A8I5Y148 (UniProtKB/TrEMBL),   A6I210 (UniProtKB/TrEMBL),   A0A8I6AEJ3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001164002   ⟸   NM_001170531
- Peptide Label: isoform 1
- UniProtKB: P28818 (UniProtKB/Swiss-Prot),   A6I209 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000070883   ⟸   ENSRNOT00000082757
RefSeq Acc Id: ENSRNOP00000018794   ⟸   ENSRNOT00000018794
RefSeq Acc Id: ENSRNOP00000077058   ⟸   ENSRNOT00000106070
RefSeq Acc Id: ENSRNOP00000090813   ⟸   ENSRNOT00000094519
Protein Domains
DH   IQ   N-terminal Ras-GEF   PH   Ras-GEF

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P28818-F1-model_v2 AlphaFold P28818 1-1244 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13696178
Promoter ID:EPDNEW_R6700
Type:multiple initiation site
Name:Rasgrf1_1
Description:RAS protein-specific guanine nucleotide-releasing factor 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0897,291,549 - 97,291,609EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620395 AgrOrtholog
BioCyc Gene G2FUF-29576 BioCyc
Ensembl Genes ENSRNOG00000014025 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000018794 ENTREZGENE
  ENSRNOT00000018794.9 UniProtKB/TrEMBL
  ENSRNOT00000082757.2 UniProtKB/TrEMBL
  ENSRNOT00000094519.1 UniProtKB/TrEMBL
  ENSRNOT00000106070 ENTREZGENE
  ENSRNOT00000106070.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.840.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  1.20.900.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  2.30.29.30 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Son of sevenless (SoS) protein Chain: S domain 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7312874 IMAGE-MGC_LOAD
InterPro DBL_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DH-domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GDS_CDC24_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  IQ_motif_EF-hand-BS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PH-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PH_domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ras-like_GEF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ras-like_Gua-exchang_fac_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ras_G-nucl-exch_fac_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ras_GEF_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RASGEF_cat_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RASGEF_cat_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:192213 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:109293 IMAGE-MGC_LOAD
NCBI Gene 192213 ENTREZGENE
PANTHER PTHR23113 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR23113:SF193 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam PF00169 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RasGEF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RasGEF_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RhoGEF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Rasgrf1 PhenoGen
PROSITE DH_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DH_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PH_DOMAIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PS50096 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RASGEF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RASGEF_CAT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RASGEF_NTER UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000014025 RatGTEx
SMART RasGEF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RasGEFN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RhoGEF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SM00233 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP PH domain-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF48065 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF48366 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0G2JZ23_RAT UniProtKB/TrEMBL
  A0A8I5Y148 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6AEJ3 ENTREZGENE, UniProtKB/TrEMBL
  A6I209 ENTREZGENE, UniProtKB/TrEMBL
  A6I210 ENTREZGENE, UniProtKB/TrEMBL
  F1LM43_RAT UniProtKB/TrEMBL
  P28818 ENTREZGENE
  Q5BJV1_RAT UniProtKB/TrEMBL
  Q71UW1_RAT UniProtKB/TrEMBL
  RGRF1_RAT UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2005-01-20 Rasgrf1  RAS protein-specific guanine nucleotide-releasing factor 1      Symbol and Name status set to approved 1299863 APPROVED
2002-08-07 Rasgrf1  RAS protein-specific guanine nucleotide-releasing factor 1      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_expression paternal-specific monoallelic expression in neonatal brain 1299269