Fdx1 (ferredoxin 1) - Rat Genome Database

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Gene: Fdx1 (ferredoxin 1) Rattus norvegicus
Analyze
Symbol: Fdx1
Name: ferredoxin 1
RGD ID: 62036
Description: Contributes to cholesterol monooxygenase (side-chain-cleaving) activity. Involved in several processes, including cellular response to epinephrine stimulus; cellular response to forskolin; and cellular response to leptin stimulus. Located in mitochondrial crista and mitochondrial matrix. Biomarker of pancreatitis. Orthologous to human FDX1 (ferredoxin 1); PARTICIPATES IN aldosterone biosynthetic pathway; cortisol biosynthetic pathway; estradiol biosynthetic pathway; INTERACTS WITH 1-naphthyl isothiocyanate; 17alpha-ethynylestradiol; 2,2',4,4',5,5'-hexachlorobiphenyl.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: adrenal ferredoxin; adrenodoxin, mitochondrial; ferredoxin-1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8861,164,839 - 61,183,645 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl861,164,839 - 61,183,583 (-)EnsemblGRCr8
mRatBN7.2852,268,536 - 52,287,344 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl852,268,536 - 52,287,414 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx857,817,827 - 57,836,608 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0856,096,794 - 56,115,575 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0853,961,051 - 53,979,836 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0856,373,729 - 56,393,199 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl856,373,723 - 56,393,233 (-)Ensemblrn6Rnor6.0
Rnor_5.0854,958,315 - 54,977,222 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4855,291,396 - 55,310,507 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera851,793,129 - 51,811,786 (-)NCBICelera
RGSC_v3.1855,323,249 - 55,329,561 (-)NCBI
Cytogenetic Map8q24NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View
pancreatitis  (IEP)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1-naphthyl isothiocyanate  (EXP)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (EXP)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2,4-dinitrotoluene  (EXP)
2-hydroxypropanoic acid  (ISO)
3',5'-cyclic AMP  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
6-propyl-2-thiouracil  (EXP)
8-Br-cAMP  (ISO)
acetamide  (EXP)
aconitine  (EXP)
all-trans-retinoic acid  (ISO)
amitrole  (EXP)
ammonium chloride  (EXP)
arsenite(3-)  (ISO)
benzo[a]pyrene  (ISO)
beta-naphthoflavone  (EXP,ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
caffeine  (EXP)
carbon nanotube  (ISO)
CGP 52608  (ISO)
chloroprene  (ISO)
chlorpyrifos  (ISO)
cisplatin  (ISO)
clofibrate  (ISO)
colforsin daropate hydrochloride  (ISO)
copper(II) chloride  (ISO)
cyclosporin A  (ISO)
dexamethasone  (EXP,ISO)
dextran sulfate  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (EXP)
diethylstilbestrol  (EXP,ISO)
diuron  (ISO)
elesclomol  (ISO)
endosulfan  (EXP)
erianin  (ISO)
ethanol  (EXP)
Evodiamine  (ISO)
ferulic acid  (ISO)
flavonoids  (EXP)
folic acid  (ISO)
FR900359  (ISO)
glafenine  (EXP)
hydrogen peroxide  (ISO)
inulin  (ISO)
ketoconazole  (EXP)
lead(0)  (ISO)
lipopolysaccharide  (ISO)
methimazole  (EXP)
methoxyacetic acid  (EXP)
methoxychlor  (EXP)
methylmercury chloride  (EXP)
mono(2-ethylhexyl) phthalate  (EXP,ISO)
Monobutylphthalate  (EXP)
myricetin  (ISO)
N-nitrosodiethylamine  (EXP)
nefazodone  (EXP)
organophosphorus compound  (EXP)
ozone  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP)
perfluorooctane-1-sulfonic acid  (ISO)
phenylephrine  (EXP)
phosgene  (ISO)
pirinixic acid  (EXP,ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
quercetin  (ISO)
rac-lactic acid  (ISO)
resveratrol  (EXP)
rotenone  (EXP)
sodium arsenite  (ISO)
sodium dichromate  (EXP)
sulfadimethoxine  (EXP)
tert-butyl ethyl ether  (EXP)
tert-butyl hydroperoxide  (ISO)
testosterone  (EXP)
tetrachloromethane  (EXP,ISO)
tetracycline  (ISO)
titanium dioxide  (ISO)
trichloroethene  (EXP)
valproic acid  (ISO)
vinclozolin  (EXP)
zearalenone  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Leptin attenuates follicular apoptosis and accelerates the onset of puberty in immature rats. Almog B, etal., Mol Cell Endocrinol. 2001 Oct 25;183(1-2):179-91.
2. Localization of multiple forms of inducible cytochromes P450 in rat liver mitochondria: immunological characteristics and patterns of xenobiotic substrate metabolism. Anandatheerthavarada HK, etal., Arch Biochem Biophys. 1997 Mar 1;339(1):136-50.
3. Leptin modulates the glucocorticoid-induced ovarian steroidogenesis. Barkan D, etal., Endocrinology. 1999 Apr;140(4):1731-8.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. Induction and mitochondrial localization of cytochrome P450scc system enzymes in normal and transformed ovarian granulosa cells. Hanukoglu I, etal., J Cell Biol. 1990 Oct;111(4):1373-81.
6. Gonadotropin stimuli increase adrenodoxin immunoreactivity in the mitochondria of rat ovarian cells. Izumi S and Mitani F, Acta Histochem. 2005;107(4):269-77. Epub 2005 Sep 1.
7. Pancreatic gene expression during the initiation of acute pancreatitis: identification of EGR-1 as a key regulator. Ji B, etal., Physiol Genomics. 2003 Jun 24;14(1):59-72.
8. Iron-sulfur cluster biogenesis in mammalian cells: New insights into the molecular mechanisms of cluster delivery. Maio N and Rouault TA, Biochim Biophys Acta. 2015 Jun;1853(6):1493-512. doi: 10.1016/j.bbamcr.2014.09.009. Epub 2014 Sep 19.
9. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
10. Androgen synthesis in adrenarche. Miller WL Rev Endocr Metab Disord. 2009 Mar;10(1):3-17.
11. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
12. GOA pipeline RGD automated data pipeline
13. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
14. Mitochondrial targeted cytochrome P450 2E1 (P450 MT5) contains an intact N terminus and requires mitochondrial specific electron transfer proteins for activity. Robin MA, etal., J Biol Chem. 2001 Jul 6;276(27):24680-9. Epub 2001 Apr 26.
15. Expression of the P450 side-chain cleavage and adrenodoxin genes begins during early stages of adrenal cortex development. Rogler LE and Pintar JE, Mol Endocrinol. 1993 Mar;7(3):453-61.
16. cDNA cloning, overproduction and characterization of rat adrenodoxin reductase. Sagara Y, etal., Biochim Biophys Acta 1999 Oct 12;1434(2):284-95.
17. Purification and characterization of rat adrenodoxin. Sagara Y, etal., Biochimie. 1995;77(9):719-23.
18. Cloning and sequence analysis of a full-length cDNA of rat adrenodoxin. Sagara Y, etal., Biol Pharm Bull 1996 Jan;19(1):39-41.
19. Establishment and characterization of steroidogenic granulosa cells expressing beta(2)-adrenergic receptor: regulation of adrenodoxin and steroidogenic acute regulatory protein by adrenergic agents. Selvaraj N, etal., Mol Cell Endocrinol. 2000 Oct 25;168(1-2):53-63.
20. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
Additional References at PubMed
PMID:1863358   PMID:7495857   PMID:14651853   PMID:18614015   PMID:21636783   PMID:37858707  


Genomics

Comparative Map Data
Fdx1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8861,164,839 - 61,183,645 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl861,164,839 - 61,183,583 (-)EnsemblGRCr8
mRatBN7.2852,268,536 - 52,287,344 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl852,268,536 - 52,287,414 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx857,817,827 - 57,836,608 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0856,096,794 - 56,115,575 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0853,961,051 - 53,979,836 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0856,373,729 - 56,393,199 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl856,373,723 - 56,393,233 (-)Ensemblrn6Rnor6.0
Rnor_5.0854,958,315 - 54,977,222 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4855,291,396 - 55,310,507 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera851,793,129 - 51,811,786 (-)NCBICelera
RGSC_v3.1855,323,249 - 55,329,561 (-)NCBI
Cytogenetic Map8q24NCBI
FDX1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3811110,429,331 - 110,464,884 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl11110,429,379 - 110,464,884 (+)Ensemblhg38GRCh38
GRCh3711110,300,672 - 110,335,608 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3611109,805,804 - 109,840,815 (+)NCBIBuild 36Build 36hg18NCBI36
Build 3411109,805,803 - 109,840,814NCBI
Celera11107,454,082 - 107,489,091 (+)NCBICelera
Cytogenetic Map11q22.3NCBI
HuRef11106,225,358 - 106,260,247 (+)NCBIHuRef
CHM1_111110,183,752 - 110,218,730 (+)NCBICHM1_1
T2T-CHM13v2.011110,439,522 - 110,475,104 (+)NCBIT2T-CHM13v2.0
Fdx1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39951,854,323 - 51,874,902 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl951,854,606 - 51,874,856 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38951,943,023 - 51,963,602 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl951,943,306 - 51,963,556 (-)Ensemblmm10GRCm38
MGSCv37951,751,412 - 51,771,638 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36951,695,672 - 51,715,898 (-)NCBIMGSCv36mm8
Celera949,216,519 - 49,236,839 (-)NCBICelera
Cytogenetic Map9A5.3NCBI
cM Map928.62NCBI
Fdx1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541212,286,408 - 12,316,707 (+)Ensembl
ChiLan1.0NW_00495541212,280,900 - 12,312,930 (+)NCBIChiLan1.0ChiLan1.0
FDX1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v29111,170,868 - 111,207,767 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan111112,262,007 - 112,298,701 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v011105,311,613 - 105,345,414 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.111109,158,419 - 109,190,869 (+)NCBIPanPan1.1PanPan1.1panPan2
FDX1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1522,452,011 - 22,485,581 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl522,451,209 - 22,485,395 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha522,371,400 - 22,404,749 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0522,477,844 - 22,511,361 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl522,479,333 - 22,511,216 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1522,536,376 - 22,569,968 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0522,436,016 - 22,540,532 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0522,485,417 - 22,518,946 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Fdx1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494792,799,925 - 92,827,430 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366123,874,748 - 3,905,825 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049366123,878,179 - 3,905,678 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
FDX1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl938,375,984 - 38,404,832 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1938,376,147 - 38,399,026 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
FDX1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11101,777,499 - 101,813,753 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1101,777,678 - 101,816,379 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366604324,135,097 - 24,172,218 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Fdx1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247845,406,459 - 5,460,581 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Fdx1
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11454,595,982 - 54,614,845 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Fdx1
225 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:17
Count of miRNA genes:17
Interacting mature miRNAs:17
Transcripts:ENSRNOT00000016263
Prediction methods:Miranda
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1298065Scl16Serum cholesterol level QTL 163.8blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)83975280384752803Rat
2313057Bss76Bone structure and strength QTL 7630.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)83910625891341052Rat
1549908Neudeg1Neurodegradation QTL 15.50nervous system integrity trait (VT:0010566)logarithm of the ratio of the lesioned side motor neuron count to contralateral side motor neuron count (CMO:0001986)858337123103337123Rat
2317030Wbc5White blood cell count QTL 53.210.005leukocyte quantity (VT:0000217)white blood cell count (CMO:0000027)81699464261994642Rat
1554321Bmd3Bone mineral density QTL 37.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)849849908118871671Rat
2313067Bss77Bone structure and strength QTL 773.10.0001tibia size trait (VT:0100001)tibia midshaft endosteal cross-sectional area (CMO:0001716)83910625891341052Rat
1578769Uae31Urinary albumin excretion QTL 313.30.001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)839106363103375781Rat
1298079Activ2Activity QTL 29.50.000001voluntary movement trait (VT:0003491)rearing measurement (CMO:0001515)85076395195763951Rat
11556286Cm81Cardiac mass QTL 810.01heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)83910625884106258Rat
70161Bp62Blood pressure QTL 622.90.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)85158969999045312Rat
1358912Bw51Body weight QTL 512.95body mass (VT:0001259)body weight (CMO:0000012)860248093105248093Rat
1578765Klgr1Kidney lesion grade QTL 13.30.0001kidney morphology trait (VT:0002135)organ lesion measurement (CMO:0000677)839106363103375781Rat
61464Niddm11Non-insulin dependent diabetes mellitus QTL 113.10.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)84447792689477926Rat
2317051Aia18Adjuvant induced arthritis QTL 182.42joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)81699464261994642Rat
4889938Bss89Bone structure and strength QTL 893.8tibia size trait (VT:0100001)tibia cortical bone volume (CMO:0001725)85899169791341052Rat
1578755Pur5Proteinuria QTL 53.30.0001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)839106258103375958Rat
2313086Bss60Bone structure and strength QTL 604.10.0001tibia length (VT:0004357)tibia length (CMO:0000450)85899169791341052Rat
631210Bw3Body weight QTL35.9mesenteric fat pad mass (VT:0010427)mesenteric fat pad weight to body weight ratio (CMO:0000654)861019838121662124Rat
2313088Bss75Bone structure and strength QTL 753.10.0001body length (VT:0001256)body length, nose to rump (CMO:0000079)83910625891341052Rat
1358896Bp262Blood pressure QTL 2622.89arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)835464071107982864Rat
731182Uae24Urinary albumin excretion QTL 246.4urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)84754141992541419Rat
724514Uae15Urinary albumin excretion QTL 152.9urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)83776085961459705Rat
631648Stl5Serum triglyceride level QTL 540.0003blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)83546407171842899Rat
1331837Bw23Body weight QTL 234.190.00007body mass (VT:0001259)body weight (CMO:0000012)855428416107963099Rat
61353Bp35Blood pressure QTL 350.001arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)83910625884106258Rat
737824Hcar10Hepatocarcinoma resistance QTL 102.9liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)84961020468373388Rat
631842Inf1Infertility severity QTL 14.10.001seminal gland mass (VT:0010524)seminal vesicle wet weight (CMO:0001603)83154366176543661Rat
1331769Rf39Renal function QTL 393.871urine output (VT:0003620)timed urine volume (CMO:0000260)850763951107970527Rat
1359033Bp273Blood pressure QTL 273arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)83910625884106258Rat
1358906Bp253Blood pressure QTL 25340.0004arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)84961020494610204Rat
61358Bp39Blood pressure QTL 392arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)84444783789447837Rat
1358907Cm40Cardiac mass QTL 401.89heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)835464071107982864Rat
1598824Memor4Memory QTL 42.5exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)81799386262252873Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)855428333127966348Rat
1331744Bp217Blood pressure QTL 2173.398arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)83910625867378345Rat
2316950Scl66Serum cholesterol level QTL 664.1blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)839106363114525825Rat
2313046Bss78Bone structure and strength QTL 783.50.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)83910625891341052Rat
1582254Kidm31Kidney mass QTL 313kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)84924517894245178Rat
724540Uae8Urinary albumin excretion QTL 85urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)839106258103375958Rat
1358892Kidm26Kidney mass QTL 263.69kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)835464071107982864Rat
631216Stl9Serum triglyceride level QTL 94.710.0001blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)85076395167219641Rat
1582243Bw66Body weight QTL 663.40.0048body mass (VT:0001259)body weight (CMO:0000012)84924517894245178Rat
5684973Bss100Bone structure and strength QTL 1004.7tibia area (VT:1000281)tibia area measurement (CMO:0001382)85899169791341052Rat
61373Mcs4Mammary carcinoma susceptibility QTL 41.1mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)84447504389475043Rat

Markers in Region
RH139364  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2852,268,792 - 52,269,036 (+)MAPPERmRatBN7.2
Rnor_6.0856,373,986 - 56,374,229NCBIRnor6.0
Rnor_5.0854,958,572 - 54,958,815UniSTSRnor5.0
RGSC_v3.4855,291,653 - 55,291,896UniSTSRGSC3.4
Celera851,793,386 - 51,793,629UniSTS
RH 3.4 Map8564.29UniSTS
Cytogenetic Map8q24UniSTS
AI237068  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2852,286,253 - 52,286,430 (+)MAPPERmRatBN7.2
Rnor_6.0856,392,109 - 56,392,285NCBIRnor6.0
Rnor_5.0854,976,132 - 54,976,308UniSTSRnor5.0
RGSC_v3.4855,309,417 - 55,309,593UniSTSRGSC3.4
Celera851,810,696 - 51,810,872UniSTS
RH 3.4 Map8566.5UniSTS
Cytogenetic Map8q24UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000016263   ⟹   ENSRNOP00000016263
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl852,268,538 - 52,287,414 (-)Ensembl
Rnor_6.0 Ensembl856,373,723 - 56,393,233 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000117198   ⟹   ENSRNOP00000078211
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl861,164,839 - 61,183,583 (-)Ensembl
mRatBN7.2 Ensembl852,268,536 - 52,287,083 (-)Ensembl
RefSeq Acc Id: NM_017126   ⟹   NP_058822
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8861,164,839 - 61,183,645 (-)NCBI
mRatBN7.2852,268,536 - 52,287,344 (-)NCBI
Rnor_6.0856,373,729 - 56,393,199 (-)NCBI
Rnor_5.0854,958,315 - 54,977,222 (-)NCBI
RGSC_v3.4855,291,396 - 55,310,507 (-)RGD
Celera851,793,129 - 51,811,786 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_058822 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein ABB72481 (Get FASTA)   NCBI Sequence Viewer  
  BAA08927 (Get FASTA)   NCBI Sequence Viewer  
  EDL95505 (Get FASTA)   NCBI Sequence Viewer  
  P24483 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_058822   ⟸   NM_017126
- Peptide Label: precursor
- UniProtKB: P24483 (UniProtKB/Swiss-Prot),   G3V7L0 (UniProtKB/TrEMBL),   A6J4I2 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000016263   ⟸   ENSRNOT00000016263
Ensembl Acc Id: ENSRNOP00000078211   ⟸   ENSRNOT00000117198
Protein Domains
2Fe-2S ferredoxin-type

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P24483-F1-model_v2 AlphaFold P24483 1-188 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13695964
Promoter ID:EPDNEW_R6488
Type:initiation region
Name:Fdx1_1
Description:ferredoxin 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0856,393,224 - 56,393,284EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:62036 AgrOrtholog
BioCyc Gene G2FUF-30489 BioCyc
Ensembl Genes ENSRNOG00000012123 Ensembl
Gene3D-CATH 3.10.20.30 UniProtKB/Swiss-Prot
InterPro 2Fe-2S_ferredoxin-like_sf UniProtKB/Swiss-Prot
  2Fe-2S_ferredoxin-type UniProtKB/Swiss-Prot
  Adrenodoxin UniProtKB/Swiss-Prot
  Adrenodoxin_Fe-S_BS UniProtKB/Swiss-Prot
  Beta-grasp_dom_sf UniProtKB/Swiss-Prot
KEGG Report rno:29189 UniProtKB/Swiss-Prot
NCBI Gene 29189 ENTREZGENE
PANTHER ADRENODOXIN, MITOCHONDRIAL UniProtKB/Swiss-Prot
  PTHR23426 UniProtKB/Swiss-Prot
Pfam Fer2 UniProtKB/Swiss-Prot
PhenoGen Fdx1 PhenoGen
PRINTS ADRENODOXIN UniProtKB/Swiss-Prot
PROSITE 2FE2S_FER_2 UniProtKB/Swiss-Prot
  ADX UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000012123 RatGTEx
Superfamily-SCOP SSF54292 UniProtKB/Swiss-Prot
TIGR TC217098
UniProt A0A8I5Y749_RAT UniProtKB/TrEMBL
  A6J4I2 ENTREZGENE, UniProtKB/TrEMBL
  ADX_RAT UniProtKB/Swiss-Prot
  G3V7L0 ENTREZGENE
  P24483 ENTREZGENE
  Q2XTA9_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-06-10 Fdx1  ferredoxin 1      Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in rat adrenal 61585
gene_protein 124 amino acid residues 61585