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Gene: C7 (complement C7) Rattus norvegicus

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Symbol:

Name:

complement C7

RGD ID:

620318

Description:

Biomarker of membranous glomerulonephritis and myocardial infarction. Human ortholog(s) of this gene implicated in complement component 7 deficiency. Orthologous to human C7 (complement C7); PARTICIPATES IN coagulation cascade pathway; complement system pathway; prion disease pathway; INTERACTS WITH 1-naphthyl isothiocyanate; 1-nitropropane; 17beta-estradiol.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

complement component 7; complement component C7; complement component C7-like; LOC103694886; LOC310126

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	C7 (complement C7)	HGNC	Ensembl, HomoloGene, Inparanoid, NCBI, Panther
Mus musculus (house mouse):	C7 (complement component 7)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	C7 (complement C7)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	C7 (complement C7)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	C7 (complement C7)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	C7 (complement C7)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	C7 (complement C7)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	C7 (complement C7)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	C7 (complement C7)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus rattus (black rat):	C7 (complement C7)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Other homologs ²
Homo sapiens (human):	MTNR1A (melatonin receptor 1A)	HGNC	OMA
Alliance orthologs ³
Homo sapiens (human):	C7 (complement C7)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Homo sapiens (human):	C7 (complement C7)	Alliance	DIOPT (HGNC)
Mus musculus (house mouse):	C7 (complement component 7)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	c7a (complement component 7a)	Alliance	DIOPT (Ensembl Compara\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	c7b (complement component 7b)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	c7	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	2	55,815,687 - 55,892,605 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	2	55,816,807 - 55,892,672 (-)	Ensembl				GRCr8
mRatBN7.2	2	54,088,116 - 54,165,102 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	2	54,088,116 - 54,158,535 (-)	Ensembl				mRatBN7.2
Rnor_6.0	2	54,707,621 - 54,781,624 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	2	54,709,138 - 54,777,729 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	2	73,735,309 - 73,806,693 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	2	54,147,136 - 54,250,803 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	2	49,739,049 - 49,813,376 (-)	NCBI		Celera
RGSC_v3.1	2	54,080,702 - 54,129,568 (-)	NCBI
Cytogenetic Map	2	q16	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

complement component 7 deficiency (ISO)

Experimental Liver Cirrhosis (ISO)

Experimental Seizures (IDA)

genetic disease (ISO)

membranous glomerulonephritis (IEP)

myocardial infarction (IEP)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(S)-nicotine (ISO)

1,2,4-trichloro-5-(2,5-dichlorophenyl)benzene (ISO)

1-naphthyl isothiocyanate (EXP)

1-nitropropane (EXP)

17beta-estradiol (EXP)

17beta-estradiol 3-benzoate (EXP)

2,2',4,4',5,5'-hexachlorobiphenyl (ISO)

2,2',4,4'-Tetrabromodiphenyl ether (ISO)

2,2',5,5'-tetrachlorobiphenyl (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP)

2,4,4'-trichlorobiphenyl (ISO)

2,4-diaminotoluene (EXP)

2,4-dibromophenyl 2,4,5-tribromophenyl ether (ISO)

2,6-diaminotoluene (EXP)

2-acetamidofluorene (EXP)

2-nitro-p-phenylenediamine (EXP)

2-nitropropane (EXP)

3,4-methylenedioxymethamphetamine (ISO)

4,4'-diaminodiphenylmethane (EXP)

4-acetylaminofluorene (EXP)

4-nitro-1,2-phenylenediamine (EXP)

5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole (EXP)

6-propyl-2-thiouracil (EXP)

acrylamide (EXP)

aflatoxin B1 (EXP)

amiodarone (EXP)

ammonium chloride (EXP)

amphetamine (EXP)

antirheumatic drug (ISO)

arsane (ISO)

arsenic atom (ISO)

atrazine (EXP)

benzbromarone (EXP)

benzo[a]pyrene (ISO)

benzo[b]fluoranthene (ISO)

bisphenol A (EXP,ISO)

bisphenol AF (EXP)

carbon nanotube (ISO)

chlordecone (ISO)

chrysene (ISO)

cisplatin (ISO)

clofibrate (EXP)

corosolic acid (ISO)

crocidolite asbestos (ISO)

Cuprizon (EXP)

diazinon (EXP)

dichloroacetic acid (ISO)

dimethylarsinic acid (ISO)

diquat (ISO)

diuron (EXP)

folic acid (ISO)

furan (EXP)

glyphosate (EXP)

hydrogen peroxide (ISO)

indole-3-methanol (EXP)

inulin (ISO)

irinotecan (EXP)

L-ethionine (EXP)

Mecamylamine (ISO)

nickel atom (ISO)

nickel dichloride (EXP)

nicotine (ISO)

okadaic acid (ISO)

omeprazole (EXP)

ozone (ISO)

paracetamol (ISO)

PCB138 (ISO)

perfluorooctane-1-sulfonic acid (ISO)

phenylarsine oxide (ISO)

pirinixic acid (EXP)

silicon dioxide (EXP,ISO)

sotorasib (ISO)

sunitinib (ISO)

testosterone (EXP)

tetraphene (ISO)

thioacetamide (EXP)

trametinib (ISO)

triclosan (ISO)

tris(2-chloroethyl) phosphate (ISO)

tubocurarine (ISO)

vinclozolin (EXP)

zinc atom (ISO)

zinc(0) (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

complement activation (ISO)

complement activation, classical pathway (IEA)

complement activation, GZMK pathway (ISO)

immune response (IEA)

immune system process (IEA)

innate immune response (IEA)

intracellular sodium ion homeostasis (IMP)

killing of cells of another organism (IEA,ISO)

transmembrane transport (IEA)

Cellular Component

extracellular region (IEA)

membrane attack complex (IEA,ISO)

other organism cell membrane (IEA,ISO)

plasma membrane (ISO)

Molecular Function

wide pore channel activity (ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

coagulation cascade pathway (IEA)

complement system pathway (IEA)

prion disease pathway (IEA)

systemic lupus erythematosus pathway (IEA)

References

References - curated

#	Reference Title	Reference Citation
1.	Detection of terminal complement components in experimental immune glomerular injury.	Adler S, etal., Kidney Int. 1984 Dec;26(6):830-7.
2.	The membrane attack complex of complement induces caspase activation and apoptosis.	Nauta AJ, etal., Eur J Immunol 2002 Mar;32(3):783-92.
3.	Electronic Transfer of LocusLink and RefSeq Data	NCBI rat LocusLink and RefSeq merged data July 26, 2002
4.	Sublytic complement attack increases intracellular sodium in rat skeletal muscle.	Okamoto K, etal., J Surg Res. 2000 May 15;90(2):174-82.
5.	OMIM Disease Annotation Pipeline	OMIM Disease Annotation Pipeline
6.	KEGG Annotation Import Pipeline	Pipeline to import KEGG annotations from KEGG into RGD
7.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
8.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
9.	Comprehensive gene review and curation	RGD comprehensive gene curation
10.	C5b-9 terminal complement complex protects oligodendrocytes from death by regulating Bad through phosphatidylinositol 3-kinase/Akt pathway.	Soane L, etal., J Immunol. 2001 Aug 15;167(4):2305-11.
11.	Time course studies on the initiation of complement activation in acute myocardial infarction induced by coronary artery ligation in rats.	Sumitra M, etal., Mol Cell Biochem. 2005 Jan;268(1-2):149-58.
12.	Formation of complement membrane attack complex in mammalian cerebral cortex evokes seizures and neurodegeneration.	Xiong ZQ, etal., J Neurosci. 2003 Feb 1;23(3):955-60.

Additional References at PubMed

PMID:9688553	PMID:18178252	PMID:22832194	PMID:23376485	PMID:23533145

Genomics

Comparative Map Data

C7
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	2	55,815,687 - 55,892,605 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	2	55,816,807 - 55,892,672 (-)	Ensembl				GRCr8
mRatBN7.2	2	54,088,116 - 54,165,102 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	2	54,088,116 - 54,158,535 (-)	Ensembl				mRatBN7.2
Rnor_6.0	2	54,707,621 - 54,781,624 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	2	54,709,138 - 54,777,729 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	2	73,735,309 - 73,806,693 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	2	54,147,136 - 54,250,803 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	2	49,739,049 - 49,813,376 (-)	NCBI		Celera
RGSC_v3.1	2	54,080,702 - 54,129,568 (-)	NCBI
Cytogenetic Map	2	q16	NCBI

C7
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	5	40,909,497 - 40,984,643 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	5	40,909,419 - 41,020,216 (+)	Ensembl			hg38	GRCh38
GRCh37	5	40,909,599 - 40,984,745 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	5	40,945,356 - 41,018,798 (+)	NCBI	Build 36	Build 36	hg18	NCBI36
Build 34	5	40,945,355 - 41,018,796	NCBI
Celera	5	40,798,197 - 40,871,625 (+)	NCBI		Celera
Cytogenetic Map	5	p13.1	NCBI
HuRef	5	40,861,350 - 40,935,010 (+)	NCBI		HuRef
CHM1_1	5	40,911,673 - 40,985,046 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	5	41,165,912 - 41,241,067 (+)	NCBI		T2T-CHM13v2.0

C7
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	15	5,017,232 - 5,093,230 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	15	5,018,244 - 5,093,222 (-)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	15	4,987,750 - 5,063,773 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	15	4,988,762 - 5,063,740 (-)	Ensembl			mm10	GRCm38
MGSCv37	15	4,938,822 - 5,013,662 (-)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	15	4,936,037 - 5,010,877 (-)	NCBI		MGSCv36	mm8
Celera	15	4,838,417 - 4,913,553 (-)	NCBI		Celera
Cytogenetic Map	15	A1	NCBI
cM Map	15	1.98	NCBI

C7
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0	NW_004955426	25,173,463 - 25,230,897 (+)	NCBI	ChiLan1.0	ChiLan1.0

C7
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	4	69,354,717 - 69,429,838 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	5	67,510,052 - 67,583,432 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	5	69,405,041 - 69,478,445 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	5	74,447,559 - 74,520,730 (-)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	5	74,447,559 - 74,520,649 (-)	Ensembl			panPan2	panpan1.1

C7
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	4	68,450,660 - 68,502,753 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	4	68,451,578 - 68,513,386 (-)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	4	68,133,714 - 68,185,839 (-)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	4	68,962,923 - 69,015,455 (-)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	4	68,962,925 - 69,015,307 (-)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	4	68,722,997 - 68,775,078 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	4	68,835,383 - 68,888,145 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	4	69,374,269 - 69,426,946 (-)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

C7
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024407213	229,634,993 - 229,684,377 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936518	1,689,328 - 1,731,770 (-)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936518	1,687,482 - 1,736,463 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

C7
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	16	25,846,860 - 25,903,980 (+)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	16	25,846,860 - 25,902,707 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	16	27,055,926 - 27,111,985 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

C7
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	4	39,671,625 - 39,752,336 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	4	39,671,551 - 39,753,626 (+)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666071	30,096,885 - 30,178,561 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

C7
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624759	13,992,681 - 14,114,411 (-)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624759	13,991,104 - 14,114,271 (-)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

C7
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	3	175,254,868 - 175,329,097 (+)	NCBI		Rrattus_CSIRO_v1

Variants

Variants in C7
127 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	538
Count of miRNA genes:	260
Interacting mature miRNAs:	321
Transcripts:	ENSRNOT00000060343
Prediction methods:	Microtar, Miranda, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
10755430	Coatc6	Coat color QTL 6		0.02576	coat/hair pigmentation trait (VT:0010463)	pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)	2	13325041	58325041	Rat
7387318	Stl32	Serum triglyceride level QTL 32	3.2	0.0003	blood triglyceride amount (VT:0002644)	plasma triglyceride level (CMO:0000548)	2	24117813	69117813	Rat
10755436	Coatc8	Coat color QTL 8		0.02431	coat/hair pigmentation trait (VT:0010463)	pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)	2	36750344	81750344	Rat
1298074	Bp164	Blood pressure QTL 164		0.003	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	44537979	205135428	Rat
10755499	Bp389	Blood pressure QTL 389	2.61		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	2	20695736	231474293	Rat
1358917	Cm42	Cardiac mass QTL 42	2.82		heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	2	27148328	206613235	Rat
1579916	Bp270	Blood pressure QTL 270		0.003	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	2	16051883	61051883	Rat
731167	Glom4	Glomerulus QTL 4	2.4	0.0082	kidney glomerulus morphology trait (VT:0005325)	count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)	2	22038044	67038044	Rat
1358913	Cm41	Cardiac mass QTL 41	2.73		heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	2	27148328	206613235	Rat
152025242	Bw191	Body weight QTL 191	3.62		body mass (VT:0001259)		2	40306867	124537199	Rat
1302794	Stl27	Serum triglyceride level QTL 27	4.4	0.0001	blood triglyceride amount (VT:0002644)	plasma triglyceride level (CMO:0000548)	2	27148328	145807373	Rat
9590095	Sffal3	Serum free fatty acids level QTL 3	6.78	0.001	blood free fatty acid amount (VT:0001553)	plasma free fatty acids level (CMO:0000546)	2	28889991	73889991	Rat
70174	BpQTLCluster2	Blood pressure QTL cluster 2	4.24		arterial blood pressure trait (VT:2000000)	absolute change in mean arterial blood pressure (CMO:0000533)	2	41801363	104744824	Rat
1331764	Bp205	Blood pressure QTL 205	3.476		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	2	14368707	59368707	Rat
1358901	Cm38	Cardiac mass QTL 38	2		heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	2	27148328	159440891	Rat
631208	Bw1	Body weight QTL1	5.09		mesenteric fat pad mass (VT:0010427)	mesenteric fat pad weight to body weight ratio (CMO:0000654)	2	44904355	85286097	Rat
1331760	Bp206	Blood pressure QTL 206	3.62454		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	2	4265106	205135428	Rat
1358899	Kidm23	Kidney mass QTL 23	3.88		kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	2	27148328	159440891	Rat
1358908	Bw49	Body weight QTL 49	3.36		body mass (VT:0001259)	body weight (CMO:0000012)	2	27148557	159440760	Rat
1300155	Bp174	Blood pressure QTL 174	4.09		arterial blood pressure trait (VT:2000000)	absolute change in mean arterial blood pressure (CMO:0000533)	2	44537979	112567334	Rat
2293835	Kiddil5	Kidney dilation QTL 5	3.8		kidney pelvis morphology trait (VT:0004194)	hydronephrosis severity score (CMO:0001208)	2	44537979	159440891	Rat
1358910	Kidm27	Kidney mass QTL 27	5.77		kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	2	27148328	159440891	Rat
61355	Bp36	Blood pressure QTL 36	2.9		blood pressure trait (VT:0000183)	systolic blood pressure (CMO:0000004)	2	7605533	104774005	Rat
1358911	Kidm28	Kidney mass QTL 28	5.42		kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	2	27148328	159440891	Rat
631266	Bp132	Blood pressure QTL 132		0.0005	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	47856345	205135428	Rat
1358904	Cm39	Cardiac mass QTL 39	2.26		heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	2	27148328	159440891	Rat
1354617	Bp240	Blood pressure QTL 240	4		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	2	28652666	83465677	Rat
1359034	Bp274	Blood pressure QTL 274			arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	2	51266859	96266859	Rat
2293843	Kiddil6	Kidney dilation QTL 6	3.1		kidney pelvis morphology trait (VT:0004194)	hydronephrosis severity score (CMO:0001208)	2	44537979	184731399	Rat
1358887	Bw50	Body weight QTL 50	2.39		body mass (VT:0001259)	body weight (CMO:0000012)	2	27148557	159440760	Rat
2306903	Bp336	Blood pressure QTL 336		0.01	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	38426449	111295694	Rat
1298085	Bp165	Blood pressure QTL 165		0.0006	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	44537979	205135428	Rat
2290453	Scl55	Serum cholesterol level QTL 55	2.83		blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	2	28652666	139067443	Rat
152025206	Hrtrt23	Heart rate QTL 23	5.98		heart pumping trait (VT:2000009)		2	30219200	171802126	Rat
1358894	Kidm24	Kidney mass QTL 24	4.03		kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	2	27148328	159440891	Rat
731184	Mamtr4	Mammary tumor resistance QTL 4		0.0003	mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	2	18227137	63227137	Rat
152025204	Hrtrt22	Heart rate QTL 22	5.6		heart pumping trait (VT:2000009)		2	30219200	171802126	Rat
61371	Edpm1	Estrogen-dependent pituitary mass QTL 1	4	0.05	pituitary gland mass (VT:0010496)	pituitary gland wet weight (CMO:0000853)	2	36868643	81868643	Rat
1354601	Slep1	Serum leptin concentration QTL 1	5.39		blood leptin amount (VT:0005667)	serum leptin level (CMO:0000780)	2	44904355	89904355	Rat
1582246	Cm60	Cardiac mass QTL 60	5.8		heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	2	33269996	78269996	Rat
1354603	Bp243	Blood pressure QTL 243	3.9		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	2	28652666	73652666	Rat

Markers in Region

D2Got406

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	2	54,095,032 - 54,095,332 (+)	MAPPER	mRatBN7.2
Rnor_6.0	2	54,713,408 - 54,713,707	NCBI	Rnor6.0
Rnor_5.0	2	73,741,096 - 73,741,395	UniSTS	Rnor5.0
RGSC_v3.4	2	54,151,124 - 54,151,423	UniSTS	RGSC3.4
Celera	2	49,744,841 - 49,745,140	UniSTS
Cytogenetic Map	2	q16	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
16	12	67	156	91	90	59	38	59	6	301	138	11	135	80	92	31	12	12

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001432331	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	NM_001432332	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_001054007	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_008760831	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_008775078	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063282844	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063282845	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC094562	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AF309948	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH474048	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000002	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000082548 ⟹ ENSRNOP00000074387

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	2	55,816,807 - 55,892,672 (-)	Ensembl
mRatBN7.2 Ensembl	2	54,088,116 - 54,158,535 (-)	Ensembl
Rnor_6.0 Ensembl	2	54,709,138 - 54,777,729 (-)	Ensembl

RefSeq Acc Id:

XM_063282844 ⟹ XP_063138914

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	2	55,815,687 - 55,892,605 (-)	NCBI

RefSeq Acc Id:

XM_063282845 ⟹ XP_063138915

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	2	55,815,687 - 55,892,594 (-)	NCBI

Protein Sequences


Protein RefSeqs	NP_001419260	(Get FASTA)	NCBI Sequence Viewer
	NP_001419261	(Get FASTA)	NCBI Sequence Viewer
	XP_063138914	(Get FASTA)	NCBI Sequence Viewer
	XP_063138915	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAG32053	(Get FASTA)	NCBI Sequence Viewer
	EDL75730	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000112708
	ENSRNOP00000112708.1

Ensembl Acc Id:

ENSRNOP00000074387 ⟸ ENSRNOT00000082548

RefSeq Acc Id:	XP_063138914 ⟸ XM_063282844
- Peptide Label:	isoform X1

RefSeq Acc Id:	XP_063138915 ⟸ XM_063282845
- Peptide Label:	isoform X2

Protein Domains

MACPF

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-A0A0G2K7X7-F1-model_v2	AlphaFold	A0A0G2K7X7	1-846	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:620318	AgrOrtholog
BioCyc Gene	G2FUF-54182	BioCyc
Ensembl Genes	ENSRNOG00000061379	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000082548	ENTREZGENE
	ENSRNOT00000082548.3	UniProtKB/TrEMBL
Gene3D-CATH	Low-density Lipoprotein Receptor	UniProtKB/TrEMBL
	Thrombospondin type-1 (TSP1) repeat	UniProtKB/TrEMBL
InterPro	LDL_receptor-like_sf	UniProtKB/TrEMBL
	LDLR_class-A_CS	UniProtKB/TrEMBL
	LDrepeatLR_classA_rpt	UniProtKB/TrEMBL
	MAC_perforin	UniProtKB/TrEMBL
	MACPF	UniProtKB/TrEMBL
	MACPF_CS	UniProtKB/TrEMBL
	TSP1_rpt	UniProtKB/TrEMBL
	TSP1_rpt_sf	UniProtKB/TrEMBL
NCBI Gene	117517	ENTREZGENE
PANTHER	COMPLEMENT COMPONENT C6	UniProtKB/TrEMBL
	COMPLEMENT COMPONENT C7	UniProtKB/TrEMBL
Pfam	Ldl_recept_a	UniProtKB/TrEMBL
	MACPF	UniProtKB/TrEMBL
	TSP_1	UniProtKB/TrEMBL
PhenoGen	C7	PhenoGen
PRINTS	COMPLEMENTC9	UniProtKB/TrEMBL
	TSP1REPEAT	UniProtKB/TrEMBL
PROSITE	LDLRA_1	UniProtKB/TrEMBL
	LDLRA_2	UniProtKB/TrEMBL
	MACPF_1	UniProtKB/TrEMBL
	MACPF_2	UniProtKB/TrEMBL
	TSP1	UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000061379	RatGTEx
SMART	LDLa	UniProtKB/TrEMBL
	MACPF	UniProtKB/TrEMBL
	TSP1	UniProtKB/TrEMBL
Superfamily-SCOP	LDL receptor-like module	UniProtKB/TrEMBL
	TSP-1 type 1 repeat	UniProtKB/TrEMBL
UniProt	A0ABK0M8W6_RAT	UniProtKB/TrEMBL
	A6KGD5_RAT	UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2021-03-09	C7	complement C7	LOC103694886	complement component C7-like	Data merged from RGD:9123610	737654	PROVISIONAL
2016-08-18	C7	complement C7	C7	complement component 7	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2014-08-25	LOC103694886	complement component C7-like			Symbol and Name status set to provisional	70820	PROVISIONAL
2006-04-27	C7	complement component 7	C7_predicted	complement component 7 (predicted)	Data merged from RGD:1307923	737654	APPROVED
2005-01-20	C7	complement component 7			Symbol and Name status set to approved	1299863	APPROVED
2005-01-12	C7_predicted	complement component 7 (predicted)			Symbol and Name status set to approved	70820	APPROVED
2002-08-07	C7	complement component 7			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

Imported Annotations - KEGG (archival)

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

Imported Annotations - KEGG (archival)