Amph (amphiphysin) - Rat Genome Database

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Gene: Amph (amphiphysin) Rattus norvegicus
Analyze
Symbol: Amph
Name: amphiphysin
RGD ID: 620274
Description: Enables phosphatase binding activity. Involved in positive regulation of endocytosis. Located in axon terminus. Is active in postsynaptic endocytic zone. Is extrinsic component of synaptic vesicle membrane. Orthologous to human AMPH (amphiphysin); PARTICIPATES IN Fc gamma receptor mediated signaling pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 3,3',4,4',5-pentachlorobiphenyl; ammonium chloride.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Amph1; amphiphysin 1; amphiphysin-like; LOC100909679; LOC687233; similar to amphiphysin 1; uncharacterized protein LOC100909679
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81750,435,018 - 50,678,583 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1750,435,018 - 50,678,501 (-)EnsemblGRCr8
mRatBN7.21745,739,385 - 45,982,905 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1745,739,395 - 45,983,315 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1748,180,900 - 48,690,815 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01752,949,166 - 53,178,746 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01747,057,349 - 47,292,588 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01748,304,324 - 48,562,838 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1748,304,322 - 48,562,905 (-)Ensemblrn6Rnor6.0
Rnor_5.01746,357,604 - 46,621,763 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41753,558,804 - 53,802,936NCBIRGSC_v3.4RGSC_v3.4rn4
RGSC_v3.11753,561,655 - 53,805,777NCBI
Cytogenetic Map17q11NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View
COVID-19  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Syndapin I and endophilin I bind overlapping proline-rich regions of dynamin I: role in synaptic vesicle endocytosis. Anggono V and Robinson PJ, J Neurochem. 2007 Aug;102(3):931-43. Epub 2007 Apr 16.
2. Dynamics and nanoscale organization of the postsynaptic endocytic zone at excitatory synapses. Catsburg LA, etal., Elife. 2022 Jan 24;11:e74387. doi: 10.7554/eLife.74387.
3. Dynamin is a minibrain kinase/dual specificity Yak1-related kinase 1A substrate. Chen-Hwang MC, etal., J Biol Chem 2002 May 17;277(20):17597-604.
4. Decreased synaptic vesicle recycling efficiency and cognitive deficits in amphiphysin 1 knockout mice. Di Paolo G, etal., Neuron 2002 Feb 28;33(5):789-804.
5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
6. The calcineurin-binding protein cain is a negative regulator of synaptic vesicle endocytosis. Lai MM, etal., J Biol Chem. 2000 Nov 3;275(44):34017-20.
7. Amphiphysin, a novel protein associated with synaptic vesicles. Lichte B, etal., EMBO J. 1992 Jul;11(7):2521-30.
8. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
9. Synaptojanin forms two separate complexes in the nerve terminal. Interactions with endophilin and amphiphysin. Micheva KD, etal., J Biol Chem. 1997 Oct 24;272(43):27239-45. doi: 10.1074/jbc.272.43.27239.
10. Dynamin 2 cooperates with amphiphysin 1 in phagocytosis in sertoli cells. Nakanishi A, etal., Acta Med Okayama. 2008 Dec;62(6):385-91.
11. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
12. Identification and characterization of a synaptojanin 2 splice isoform predominantly expressed in nerve terminals. Nemoto Y, etal., J Biol Chem 2001 Nov 2;276(44):41133-42.
13. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
14. GOA pipeline RGD automated data pipeline
15. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
16. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
17. The NECAP PHear domain increases clathrin accessory protein binding potential. Ritter B, etal., EMBO J. 2007 Sep 19;26(18):4066-77. Epub 2007 Aug 30.
18. NECAP 1 regulates AP-2 interactions to control vesicle size, number, and cargo during clathrin-mediated endocytosis. Ritter B, etal., PLoS Biol. 2013 Oct;11(10):e1001670. doi: 10.1371/journal.pbio.1001670. Epub 2013 Oct 1.
19. The epsins define a family of proteins that interact with components of the clathrin coat and contain a new protein module. Rosenthal JA, etal., J Biol Chem 1999 Nov 26;274(48):33959-65.
20. TTP specifically regulates the internalization of the transferrin receptor. Tosoni D, etal., Cell. 2005 Dec 2;123(5):875-88.
21. Crystal structure of the alpha appendage of AP-2 reveals a recruitment platform for clathrin-coat assembly. Traub LM, etal., Proc Natl Acad Sci U S A. 1999 Aug 3;96(16):8907-12.
22. Amphiphysin heterodimers: potential role in clathrin-mediated endocytosis. Wigge P, etal., Mol Biol Cell 1997 Oct;8(10):2003-15.
23. Composition of isolated synaptic boutons reveals the amounts of vesicle trafficking proteins. Wilhelm BG, etal., Science. 2014 May 30;344(6187):1023-8. doi: 10.1126/science.1252884.
24. A single PXXP motif in the C-terminal region of srGAP3 mediates binding to multiple SH3 domains. Wuertenberger S and Groemping Y, FEBS Lett. 2015 Apr 28;589(10):1156-63. doi: 10.1016/j.febslet.2015.03.014. Epub 2015 Mar 24.
25. Expression of the endocytic proteins dynamin and amphiphysin in rat gastric enterochromaffin-like cells. Zanner R, etal., J Cell Sci. 2004 May 1;117(Pt 11):2369-76.
Additional References at PubMed
PMID:8552632   PMID:9195986   PMID:9259551   PMID:9694653   PMID:11382783   PMID:15090044   PMID:15207364   PMID:15262992   PMID:15821731   PMID:15953416   PMID:16903783   PMID:17855509  
PMID:18344231   PMID:19144635   PMID:19759398   PMID:21700703   PMID:22750946   PMID:22871113   PMID:23785143   PMID:28235806   PMID:29476059  


Genomics

Comparative Map Data
Amph
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81750,435,018 - 50,678,583 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1750,435,018 - 50,678,501 (-)EnsemblGRCr8
mRatBN7.21745,739,385 - 45,982,905 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1745,739,395 - 45,983,315 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1748,180,900 - 48,690,815 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01752,949,166 - 53,178,746 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01747,057,349 - 47,292,588 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01748,304,324 - 48,562,838 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1748,304,322 - 48,562,905 (-)Ensemblrn6Rnor6.0
Rnor_5.01746,357,604 - 46,621,763 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41753,558,804 - 53,802,936NCBIRGSC_v3.4RGSC_v3.4rn4
RGSC_v3.11753,561,655 - 53,805,777NCBI
Cytogenetic Map17q11NCBI
AMPH
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38738,383,704 - 38,631,373 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl738,383,700 - 38,631,507 (-)Ensemblhg38GRCh38
GRCh37738,423,305 - 38,670,973 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36738,389,830 - 38,637,545 (-)NCBIBuild 36Build 36hg18NCBI36
Build 34738,196,545 - 38,444,260NCBI
Celera738,411,134 - 38,658,846 (-)NCBICelera
Cytogenetic Map7p14.1NCBI
HuRef738,307,292 - 38,555,371 (-)NCBIHuRef
CHM1_1738,425,940 - 38,673,786 (-)NCBICHM1_1
T2T-CHM13v2.0738,540,588 - 38,788,026 (-)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v2738,460,969 - 38,708,834 (-)NCBI
Amph
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391319,132,524 - 19,335,089 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1319,132,375 - 19,335,091 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm381318,948,142 - 19,154,032 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1318,948,205 - 19,150,921 (+)Ensemblmm10GRCm38
MGSCv371319,040,240 - 19,242,784 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361318,955,836 - 19,158,380 (+)NCBIMGSCv36mm8
Celera1319,259,525 - 19,457,406 (+)NCBICelera
Cytogenetic Map13A2NCBI
cM Map136.89NCBI
Amph
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554604,804,442 - 5,023,202 (+)Ensembl
ChiLan1.0NW_0049554604,804,400 - 5,024,312 (+)NCBIChiLan1.0ChiLan1.0
LOC100995139
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2643,214,846 - 43,461,235 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1791,539,581 - 91,785,970 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0739,015,699 - 39,262,120 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1739,250,081 - 39,495,844 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl739,250,081 - 39,495,844 (-)EnsemblpanPan2panpan1.1
AMPH
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11811,132,078 - 11,261,847 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1811,143,446 - 11,260,841 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1810,903,625 - 11,114,792 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01811,099,548 - 11,310,938 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1811,098,056 - 11,309,936 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11811,076,355 - 11,287,485 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01811,044,639 - 11,263,972 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01811,160,063 - 11,371,410 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Amph
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440511894,747,942 - 94,972,174 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647813,960,771 - 14,183,764 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493647813,959,669 - 14,183,835 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
AMPH
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl9108,799,793 - 108,971,660 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.19108,800,718 - 108,971,575 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.29119,651,630 - 119,751,221 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Amph
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474022,399,244 - 22,614,608 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462474022,399,302 - 22,615,736 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Amph
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11437,782,731 - 37,978,540 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Amph
2153 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:81
Count of miRNA genes:78
Interacting mature miRNAs:81
Transcripts:ENSRNOT00000017102
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631497Bp98Blood pressure QTL 983.66arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)174949693265155015Rat
70210Cm15Cardiac mass QTL 156.5heart right ventricle mass (VT:0007033)heart right ventricle wet weight (CMO:0000072)173006647275066472Rat
8552966Pigfal18Plasma insulin-like growth factor 1 level QTL 188.7blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)171286094257860942Rat
152023626Bp403Blood pressure QTL 4033.86arterial blood pressure trait (VT:2000000)172413612784432719Rat
2301412Kidm40Kidney mass QTL 400.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)174238816487388164Rat
9590107Sffal7Serum free fatty acids level QTL 74.810.001blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)173310464578104645Rat
2302377Scl61Serum cholesterol level QTL 614.36blood HDL cholesterol amount (VT:0000184)serum high density lipoprotein cholesterol level (CMO:0000361)17622199858177198Rat
1354654Spl7Serum phospholipid level QTL 75.5blood phospholipid amount (VT:0006084)blood phospholipid level (CMO:0001169)173803135483031354Rat
70157Niddm32Non-insulin dependent diabetes mellitus QTL 324.34blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)172266079955604694Rat
9589151Insul30Insulin level QTL 308.820.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)171286094257860942Rat
1598871Memor5Memory QTL 55.3exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)174096801789341781Rat
1581512Cm55Cardiac mass QTL 552.80.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)172723344583975845Rat
1354628Stl13Serum triglyceride level QTL 133.8blood triglyceride amount (VT:0002644)blood triglyceride level (CMO:0000118)172149899450592236Rat
1354629Scl31Serum cholesterol level QTL 314.1blood cholesterol amount (VT:0000180)blood total cholesterol level (CMO:0000051)173803135483031354Rat
61394Bp8Blood pressure QTL 82.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)172328632264246472Rat
9589057Scfw6Subcutaneous fat weight QTL 68.620.001subcutaneous adipose mass (VT:1000472)abdominal subcutaneous fat pad weight (CMO:0002069)171286094257860942Rat
1600398Edcs5Endometrial carcinoma susceptibility QTL 52.2uterus morphology trait (VT:0001120)percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759)173544694975762341Rat
2317045Aia11Adjuvant induced arthritis QTL 114.06joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)172652205171522051Rat
1559055Bp278Blood pressure QTL 2780.04arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)172385892668858926Rat
9590154Scort9Serum corticosterone level QTL 923.570.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)171286094257860942Rat
10450503Bp386Blood pressure QTL 3860.28arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)172201970567019705Rat
152025238Slep14Serum leptin concentration QTL 144.62blood leptin amount (VT:0005667)172439059584432719Rat
1354638Insul1Insulin level QTL 14.8blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)173803135483031354Rat
9590088Insglur7Insulin/glucose ratio QTL 720.380.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)171286094257860942Rat
2313854Bp343Blood pressure QTL 3433.9life span trait (VT:0005372)age at time of death (CMO:0001193)173219953455604694Rat
2317053Aia25Adjuvant induced arthritis QTL 252.69joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)171060469455604694Rat
1354635Bp245Blood pressure QTL 2456arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)173803135483031354Rat
1331765Hrtrt15Heart rate QTL 154.094heart pumping trait (VT:2000009)heart rate (CMO:0000002)171553702560531414Rat
8552928Pigfal9Plasma insulin-like growth factor 1 level QTL 99blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)173310464578104645Rat
7411666Foco31Food consumption QTL 3111.40.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)171286094257860942Rat
12904736Cm121Cardiac mass QTL 1210.043heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)174238816487388164Rat
1300148Bp192Blood pressure QTL 1923.47arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)174605012691050126Rat
12903980Cm120Cardiac mass QTL 1200.002heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)172385892668858926Rat
4889891Eae32Experimental allergic encephalomyelitis QTL 324.80.0002nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis severity score (CMO:0001419)172723344572233445Rat
4889955Bss93Bone structure and strength QTL 934.4tibia size trait (VT:0100001)tibia cortical bone volume to tibia total bone volume ratio (CMO:0001727)172723344565155015Rat
12903981Am17Aortic mass QTL 170.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)172385892668858926Rat
12903982Kidm70Kidney mass QTL 700.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)172385892668858926Rat
2324621Coatc5Coat color QTL 5coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)174265489587654895Rat
12903978Cm118Cardiac mass QTL 1180.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)172385892668858926Rat
1354619Bp242Blood pressure QTL 2426.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)173768787782687877Rat
12903979Cm119Cardiac mass QTL 1190.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)172385892668858926Rat
1300129Rf25Renal function QTL 253.03blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)174106235286062352Rat
1354663Bvd5Brain ventricular dilatation QTL 53.510.001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)173219953486201342Rat
152023740Bp406Blood pressure QTL 4066.06arterial blood pressure trait (VT:2000000)172413612784432719Rat
7488966Bp370Blood pressure QTL 3700.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)172385892668858926Rat
152023737Bp405Blood pressure QTL 4055.06arterial blood pressure trait (VT:2000000)2413612784432719Rat
152023736Bp404Blood pressure QTL 4043.78arterial blood pressure trait (VT:2000000)172413612784432719Rat
724528Uae4Urinary albumin excretion QTL 44.90.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)173604553781045537Rat

Markers in Region
RH131007  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2863,318,169 - 63,318,360 (+)MAPPERmRatBN7.2
mRatBN7.21745,886,101 - 45,886,303 (+)MAPPERmRatBN7.2
Rnor_6.01748,455,564 - 48,455,765NCBIRnor6.0
Rnor_6.0867,747,980 - 67,748,170NCBIRnor6.0
Rnor_5.01746,508,844 - 46,509,045UniSTSRnor5.0
Rnor_5.0867,476,727 - 67,476,917UniSTSRnor5.0
RGSC_v3.4867,001,823 - 67,002,013UniSTSRGSC3.4
RGSC_v3.41753,705,754 - 53,705,955UniSTSRGSC3.4
Celera1741,984,143 - 41,984,344UniSTS
Celera862,733,083 - 62,733,273UniSTS
Cytogenetic Map17q11UniSTS
Cytogenetic Map8q24UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
11 10 67 158 49 48 19 79 19 6 296 177 11 137 81 92 29 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000017102   ⟹   ENSRNOP00000017102
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1750,435,018 - 50,678,478 (-)Ensembl
mRatBN7.2 Ensembl1745,739,395 - 45,983,315 (-)Ensembl
Rnor_6.0 Ensembl1748,304,322 - 48,562,838 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000080800   ⟹   ENSRNOP00000073615
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1750,435,018 - 50,678,501 (-)Ensembl
mRatBN7.2 Ensembl1745,739,395 - 45,982,989 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000084702   ⟹   ENSRNOP00000070116
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1750,435,018 - 50,678,501 (-)Ensembl
mRatBN7.2 Ensembl1745,739,395 - 45,983,315 (-)Ensembl
Rnor_6.0 Ensembl1748,304,329 - 48,562,905 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000129058   ⟹   ENSRNOP00000111039
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1750,435,018 - 50,532,386 (-)Ensembl
RefSeq Acc Id: NM_022217   ⟹   NP_071553
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81750,435,018 - 50,678,501 (-)NCBI
mRatBN7.21745,739,385 - 45,982,883 (-)NCBI
Rnor_6.01748,304,324 - 48,562,838 (-)NCBI
Rnor_5.01746,357,604 - 46,621,763 (-)NCBI
RGSC_v3.41753,558,804 - 53,802,936 (-)RGD
Sequence:
RefSeq Acc Id: XM_039096040   ⟹   XP_038951968
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81750,435,018 - 50,581,884 (-)NCBI
mRatBN7.21745,739,385 - 45,886,191 (-)NCBI
RefSeq Acc Id: XM_039096041   ⟹   XP_038951969
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81750,435,018 - 50,678,583 (-)NCBI
mRatBN7.21745,739,385 - 45,982,905 (-)NCBI
RefSeq Acc Id: XM_039096042   ⟹   XP_038951970
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81750,435,018 - 50,678,494 (-)NCBI
mRatBN7.21745,739,385 - 45,982,867 (-)NCBI
RefSeq Acc Id: XM_063276719   ⟹   XP_063132789
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81750,435,018 - 50,678,571 (-)NCBI
RefSeq Acc Id: NP_071553   ⟸   NM_022217
- UniProtKB: O08838 (UniProtKB/Swiss-Prot)
- Sequence:
Ensembl Acc Id: ENSRNOP00000070116   ⟸   ENSRNOT00000084702
Ensembl Acc Id: ENSRNOP00000017102   ⟸   ENSRNOT00000017102
RefSeq Acc Id: XP_038951969   ⟸   XM_039096041
- Peptide Label: isoform X2
- UniProtKB: O08838 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_038951970   ⟸   XM_039096042
- Peptide Label: isoform X3
- UniProtKB: O08838 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_038951968   ⟸   XM_039096040
- Peptide Label: isoform X1
- UniProtKB: O08838 (UniProtKB/Swiss-Prot),   A0A0G2K5Z4 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000073615   ⟸   ENSRNOT00000080800
RefSeq Acc Id: XP_063132789   ⟸   XM_063276719
- Peptide Label: isoform X4
- UniProtKB: A0A0G2JX32 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000111039   ⟸   ENSRNOT00000129058
Protein Domains
BAR   SH3

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-A0A0G2K5Z4-F1-model_v2 AlphaFold A0A0G2K5Z4 1-614 view protein structure
AF-O08838-F1-model_v2 AlphaFold O08838 1-683 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13700504
Promoter ID:EPDNEW_R11028
Type:initiation region
Name:Amph_1
Description:amphiphysin
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01748,562,914 - 48,562,974EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620274 AgrOrtholog
BIND 130419
  130420
  130421
  134465
  144371
BioCyc Gene G2FUF-9132 BioCyc
Ensembl Genes ENSRNOG00000012490 Ensembl
  ENSRNOG00000059510 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000017102 ENTREZGENE
  ENSRNOT00000080800 ENTREZGENE
  ENSRNOT00000084702 ENTREZGENE
Gene3D-CATH 1.20.1270.60 UniProtKB/Swiss-Prot
  SH3 Domains UniProtKB/Swiss-Prot
InterPro AH/BAR_dom_sf UniProtKB/Swiss-Prot
  Amphiphysin UniProtKB/Swiss-Prot
  Amphiphysin_1 UniProtKB/Swiss-Prot
  Amphiphysin_I_SH3 UniProtKB/Swiss-Prot
  BAR_dom UniProtKB/Swiss-Prot
  SH3-like_dom_sf UniProtKB/Swiss-Prot
  SH3_domain UniProtKB/Swiss-Prot
KEGG Report rno:60668 UniProtKB/Swiss-Prot
NCBI Gene 60668 ENTREZGENE
PANTHER AMPHIPHYSIN UniProtKB/Swiss-Prot
  PTHR46514:SF2 UniProtKB/Swiss-Prot
Pfam BAR UniProtKB/Swiss-Prot
PhenoGen Amph PhenoGen
PRINTS AMPHIPHYSIN UniProtKB/Swiss-Prot
  AMPHIPHYSIN1 UniProtKB/Swiss-Prot
  SH3DOMAIN UniProtKB/Swiss-Prot
PROSITE BAR UniProtKB/Swiss-Prot
  SH3 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000012490 RatGTEx
  ENSRNOG00000059510 RatGTEx
SMART BAR UniProtKB/Swiss-Prot
  SH3 UniProtKB/Swiss-Prot
Superfamily-SCOP SSF103657 UniProtKB/Swiss-Prot
  SSF50044 UniProtKB/Swiss-Prot
UniProt A0A0G2JX32 ENTREZGENE, UniProtKB/TrEMBL
  A0A0G2K5Z4 ENTREZGENE, UniProtKB/TrEMBL
  A0ABK0M3P1_RAT UniProtKB/TrEMBL
  AMPH_RAT UniProtKB/Swiss-Prot
  F1LPP0_RAT UniProtKB/TrEMBL
  O08838 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-03-09 Amph  amphiphysin  LOC100909679  amphiphysin-like  Data merged from RGD:6502395 737654 PROVISIONAL
2013-04-17 Amph  amphiphysin  LOC687233  similar to amphiphysin 1  Data merged from RGD:1587745 737654 PROVISIONAL
2012-07-05 LOC100909679  amphiphysin-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2008-02-22 Amph  amphiphysin  Amph1  amphiphysin 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-11-19 LOC687233  similar to amphiphysin 1      Symbol and Name status set to provisional 70820 PROVISIONAL
2005-01-20 Amph1  amphiphysin 1    amphiphysin  Symbol updated 1299863 APPROVED
2002-08-07 Amph1  amphiphysin      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_domains contains a src homology 3 domain 631926
gene_physical_interaction forms a heterodimer with Amph2 that activates dynamin GTPase activity 631926