Amph (amphiphysin) - Rat Genome Database

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Gene: Amph (amphiphysin) Rattus norvegicus
Analyze
Symbol: Amph
Name: amphiphysin
RGD ID: 620274
Description: Enables phosphatase binding activity. Involved in positive regulation of GTPase activity and positive regulation of endocytosis. Located in axon terminus. Is active in postsynaptic endocytic zone. Is extrinsic component of synaptic vesicle membrane. Orthologous to human AMPH (amphiphysin); PARTICIPATES IN Fc gamma receptor mediated signaling pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 3,3',4,4',5-pentachlorobiphenyl; ammonium chloride.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Amph1; amphiphysin 1; amphiphysin-like; LOC100909679; LOC687233; similar to amphiphysin 1; uncharacterized protein LOC100909679
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81750,435,018 - 50,678,583 (-)NCBIGRCr8
mRatBN7.21745,739,385 - 45,982,905 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1745,739,395 - 45,983,315 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1748,180,900 - 48,690,815 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01752,949,166 - 53,178,746 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01747,057,349 - 47,292,588 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01748,304,324 - 48,562,838 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1748,304,322 - 48,562,905 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01746,357,604 - 46,621,763 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41753,558,804 - 53,802,936NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11753,561,655 - 53,805,777NCBI
Cytogenetic Map17q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model



  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
AmphRatCOVID-19  ISOAMPH (Homo sapiens)9068941mRNA:increased expression:peripheral blood mononuclear cell (human)RGDPMID:32228226 and REF_RGD_ID:28912744
Object Symbol
Species
Term
Qualifier
Evidence
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Reference
Notes
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Original Reference(s)
AmphRatpleomorphic xanthoastrocytoma  ISOAMPH (Homo sapiens)8554872ClinVar Annotator: match by term: Pleomorphic xanthoastrocytomaClinVarPMID:28299358

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Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
AmphRat1,2-dichloroethane decreases expressionISOAmph (Mus musculus)6480464ethylene dichloride results in decreased expression of AMPH mRNACTDPMID:28960355
AmphRat1,2-dimethylhydrazine multiple interactionsISOAmph (Mus musculus)6480464[1 and 2-Dimethylhydrazine co-treated with Folic Acid] results in increased expression of AMPH mRNACTDPMID:22206623
AmphRat17alpha-ethynylestradiol multiple interactionsISOAmph (Mus musculus)6480464[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of AMPH mRNACTDPMID:17942748
AmphRat2,3,7,8-tetrachlorodibenzodioxine multiple interactionsISOAmph (Mus musculus)6480464[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of AMPH mRNACTDPMID:17942748
AmphRat2,3,7,8-tetrachlorodibenzodioxine increases expressionEXP 6480464Tetrachlorodibenzodioxin results in increased expression of AMPH mRNACTDPMID:33387578
AmphRat2,3,7,8-tetrachlorodibenzodioxine decreases expressionEXP 6480464Tetrachlorodibenzodioxin results in decreased expression of AMPH mRNACTDPMID:22808131
AmphRat3,3',4,4',5-pentachlorobiphenyl decreases expressionEXP 64804643 more ...CTDPMID:23196670
AmphRat3-isobutyl-1-methyl-7H-xanthine multiple interactionsISOAMPH (Homo sapiens)6480464[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of AMPH mRNACTDPMID:28628672
AmphRat4-hydroxynon-2-enal decreases expressionISOAMPH (Homo sapiens)64804644-hydroxy-2-nonenal results in decreased expression of AMPH mRNACTDPMID:12419474
AmphRataflatoxin B1 decreases methylationISOAMPH (Homo sapiens)6480464Aflatoxin B1 results in decreased methylation of AMPH geneCTDPMID:27153756
AmphRataflatoxin B1 increases methylationISOAMPH (Homo sapiens)6480464Aflatoxin B1 results in increased methylation of AMPH intronCTDPMID:30157460
AmphRatall-trans-retinoic acid decreases expressionISOAMPH (Homo sapiens)6480464Tretinoin results in decreased expression of AMPH mRNACTDPMID:21934132
AmphRatammonium chloride affects expressionEXP 6480464Ammonium Chloride affects the expression of AMPH mRNACTDPMID:16483693
AmphRatantirheumatic drug increases expressionISOAMPH (Homo sapiens)6480464Antirheumatic Agents results in increased expression of AMPH mRNACTDPMID:24449571
AmphRatbenzo[a]pyrene increases methylationISOAMPH (Homo sapiens)6480464Benzo(a)pyrene results in increased methylation of AMPH 5' UTRCTDPMID:27901495
AmphRatbenzo[a]pyrene increases expressionISOAMPH (Homo sapiens)6480464Benzo(a)pyrene results in increased expression of AMPH mRNACTDPMID:32234424
AmphRatbenzo[a]pyrene affects methylationISOAMPH (Homo sapiens)6480464Benzo(a)pyrene affects the methylation of AMPH 3' UTRCTDPMID:27901495
AmphRatbenzo[a]pyrene increases methylationISOAmph (Mus musculus)6480464Benzo(a)pyrene results in increased methylation of AMPH intronCTDPMID:27901495
AmphRatbis(2-ethylhexyl) phthalate decreases expressionISOAMPH (Homo sapiens)6480464Diethylhexyl Phthalate results in decreased expression of AMPH mRNACTDPMID:31163220
AmphRatbisphenol A decreases expressionEXP 6480464bisphenol A results in decreased expression of AMPH mRNACTDPMID:25181051 more ...

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Biological Process

  

Cellular Component
1 to 20 of 23 rows

  
Object Symbol
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Evidence
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Original Reference(s)
AmphRataxon terminus  IDA 631926 RGD 
AmphRatcytoplasm located_inIEAUniProtKB-SubCell:SL-00861600115GO_REF:0000044UniProtGO_REF:0000044
AmphRatcytoplasm located_inIEAUniProtKB-KW:KW-09631600115GO_REF:0000043UniProtGO_REF:0000043
AmphRatcytoplasm located_inIEAInterPro:IPR0041481600115GO_REF:0000002InterProGO_REF:0000002
AmphRatcytoplasmic vesicle located_inIEAUniProtKB-KW:KW-09681600115GO_REF:0000043UniProtGO_REF:0000043
AmphRatcytoskeleton located_inIEAUniProtKB-KW:KW-02061600115GO_REF:0000043UniProtGO_REF:0000043
AmphRatcytoskeleton located_inIEAUniProtKB-SubCell:SL-00901600115GO_REF:0000044UniProtGO_REF:0000044
AmphRatextrinsic component of synaptic vesicle membrane is_active_inIDA 13702221PMID:1628617SynGO 
AmphRatglutamatergic synapse is_active_inISOAmph (Mus musculus)1624291 PMID:11879655RGDPMID:11879655
AmphRatleading edge membrane located_inISOAMPH (Homo sapiens)1624291 PMID:22750946RGDPMID:22750946
AmphRatleading edge membrane located_inIEAUniProtKB:P49418 and ensembl:ENSP000003486021600115GO_REF:0000107EnsemblGO_REF:0000107
AmphRatmembrane located_inIEAUniProtKB-KW:KW-04721600115GO_REF:0000043UniProtGO_REF:0000043
AmphRatphotoreceptor ribbon synapse is_active_inISOAmph (Mus musculus)1624291 PMID:23785143RGDPMID:23785143
AmphRatplasma membrane is_active_inIBAFB:FBgn0027356 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
AmphRatpostsynaptic endocytic zone is_active_inIDA 405650252PMID:35072626SynGO 
AmphRatpostsynaptic endocytic zone is_active_inIMP 405650252PMID:35072626SynGO 
AmphRatpresynapse is_active_inISOAmph (Mus musculus)1624291 PMID:11879655RGDPMID:11879655
AmphRatpresynaptic endocytic zone is_active_inISOAmph (Mus musculus)1624291 PMID:23785143RGDPMID:23785143
AmphRatsynapse located_inIEAUniProtKB-KW:KW-07701600115GO_REF:0000043UniProtGO_REF:0000043
AmphRatsynaptic vesicle located_inISOAmph (Mus musculus)1624291 PMID:11879655RGDPMID:11879655
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Molecular Function
1 to 20 of 22 rows

  
Object Symbol
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Reference
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Source
Original Reference(s)
AmphRatphosphatase binding  IPISynj1 (Rattus norvegicus)628465protein C-terminus bindingRGD 
AmphRatphospholipid binding enablesISOAMPH (Homo sapiens)1624291 PMID:22750946RGDPMID:22750946
AmphRatphospholipid binding enablesIBAPANTHER:PTN002509858 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
AmphRatphospholipid binding enablesIEAUniProtKB:P49418 and ensembl:ENSP000003486021600115GO_REF:0000107EnsemblGO_REF:0000107
AmphRatprotein binding  IPISynj2_v1 (Rattus norvegicus)628465protein C-terminus bindingRGD 
AmphRatprotein binding  IPISynj2_v2 (Rattus norvegicus)628465protein C-terminus bindingRGD 
AmphRatprotein binding  IPISynj2_v3 (Rattus norvegicus)628465protein C-terminus bindingRGD 
AmphRatprotein binding enablesIPIUniProtKB:O4329510047166PMID:25819436IntAct 
AmphRatprotein binding enablesIPIUniProtKB:P215758554440PMID:17437541IntAct 
AmphRatprotein binding enablesIPIUniProtKB:O08839631926PMID:9348539IntAct 
AmphRatprotein binding enablesISOAMPH (Homo sapiens)1624291UniProtKB:O00499 more ...RGDPMID:17762867 more ...
AmphRatprotein binding enablesIPIUniProtKB:Q9CR9513432276PMID:24130457IntAct 
AmphRatprotein binding enablesIPIUniProtKB:P21575631926PMID:9348539IntAct 
AmphRatprotein binding enablesIPIUniProtKB:Q9CR958554310PMID:17762867IntAct 
AmphRatprotein binding enablesIPIUniProtKB:P390528554402PMID:16325581IntAct 
AmphRatprotein binding enablesIPIUniProtKB:O35179 and UniProtKB:P21575401827132PMID:9341169UniProt 
AmphRatprotein binding enablesISOAmph (Mus musculus)1624291PR:Q8CHC4 more ...RGDPMID:12456676 more ...
AmphRatprotein binding  IPICabin1 (Rattus norvegicus) and Dnm1 (Rattus norvegicus)10054396 RGD 
AmphRatprotein binding  IPIDnm1 (Rattus norvegicus)8554781 RGD 
AmphRatprotein binding  IPIDnm2 (Rattus norvegicus)9685149 RGD 
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Imported Annotations - KEGG (archival)

Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
AmphRatFc gamma receptor mediated signaling pathway  IEA 6907045 KEGGrno:04666

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#
Reference Title
Reference Citation
1. Syndapin I and endophilin I bind overlapping proline-rich regions of dynamin I: role in synaptic vesicle endocytosis. Anggono V and Robinson PJ, J Neurochem. 2007 Aug;102(3):931-43. Epub 2007 Apr 16.
2. Dynamics and nanoscale organization of the postsynaptic endocytic zone at excitatory synapses. Catsburg LA, etal., Elife. 2022 Jan 24;11:e74387. doi: 10.7554/eLife.74387.
3. Dynamin is a minibrain kinase/dual specificity Yak1-related kinase 1A substrate. Chen-Hwang MC, etal., J Biol Chem 2002 May 17;277(20):17597-604.
4. Decreased synaptic vesicle recycling efficiency and cognitive deficits in amphiphysin 1 knockout mice. Di Paolo G, etal., Neuron 2002 Feb 28;33(5):789-804.
5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
6. The calcineurin-binding protein cain is a negative regulator of synaptic vesicle endocytosis. Lai MM, etal., J Biol Chem. 2000 Nov 3;275(44):34017-20.
7. Amphiphysin, a novel protein associated with synaptic vesicles. Lichte B, etal., EMBO J. 1992 Jul;11(7):2521-30.
8. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
9. Synaptojanin forms two separate complexes in the nerve terminal. Interactions with endophilin and amphiphysin. Micheva KD, etal., J Biol Chem. 1997 Oct 24;272(43):27239-45. doi: 10.1074/jbc.272.43.27239.
10. Dynamin 2 cooperates with amphiphysin 1 in phagocytosis in sertoli cells. Nakanishi A, etal., Acta Med Okayama. 2008 Dec;62(6):385-91.
11. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
12. Identification and characterization of a synaptojanin 2 splice isoform predominantly expressed in nerve terminals. Nemoto Y, etal., J Biol Chem 2001 Nov 2;276(44):41133-42.
13. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
14. GOA pipeline RGD automated data pipeline
15. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
16. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
17. The NECAP PHear domain increases clathrin accessory protein binding potential. Ritter B, etal., EMBO J. 2007 Sep 19;26(18):4066-77. Epub 2007 Aug 30.
18. NECAP 1 regulates AP-2 interactions to control vesicle size, number, and cargo during clathrin-mediated endocytosis. Ritter B, etal., PLoS Biol. 2013 Oct;11(10):e1001670. doi: 10.1371/journal.pbio.1001670. Epub 2013 Oct 1.
19. The epsins define a family of proteins that interact with components of the clathrin coat and contain a new protein module. Rosenthal JA, etal., J Biol Chem 1999 Nov 26;274(48):33959-65.
20. TTP specifically regulates the internalization of the transferrin receptor. Tosoni D, etal., Cell. 2005 Dec 2;123(5):875-88.
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PMID:8552632   PMID:9195986   PMID:9259551   PMID:9694653   PMID:11382783   PMID:15090044   PMID:15207364   PMID:15262992   PMID:15821731   PMID:15953416   PMID:16903783   PMID:17855509  
PMID:18344231   PMID:19144635   PMID:19759398   PMID:21700703   PMID:22750946   PMID:22871113   PMID:23785143   PMID:28235806   PMID:29476059  



Amph
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81750,435,018 - 50,678,583 (-)NCBIGRCr8
mRatBN7.21745,739,385 - 45,982,905 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1745,739,395 - 45,983,315 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1748,180,900 - 48,690,815 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01752,949,166 - 53,178,746 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01747,057,349 - 47,292,588 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01748,304,324 - 48,562,838 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1748,304,322 - 48,562,905 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01746,357,604 - 46,621,763 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41753,558,804 - 53,802,936NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11753,561,655 - 53,805,777NCBI
Cytogenetic Map17q11NCBI
AMPH
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38738,383,704 - 38,631,373 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl738,383,704 - 38,631,420 (-)EnsemblGRCh38hg38GRCh38
GRCh37738,423,305 - 38,670,973 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36738,389,830 - 38,637,545 (-)NCBINCBI36Build 36hg18NCBI36
Build 34738,196,545 - 38,444,260NCBI
Celera738,411,134 - 38,658,846 (-)NCBICelera
Cytogenetic Map7p14.1NCBI
HuRef738,307,292 - 38,555,371 (-)NCBIHuRef
CHM1_1738,425,940 - 38,673,786 (-)NCBICHM1_1
T2T-CHM13v2.0738,540,588 - 38,788,026 (-)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v2738,460,969 - 38,708,834 (-)NCBI
Amph
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391319,132,524 - 19,335,089 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1319,132,375 - 19,335,091 (+)EnsemblGRCm39 Ensembl
GRCm381318,948,142 - 19,154,032 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1318,948,205 - 19,150,921 (+)EnsemblGRCm38mm10GRCm38
MGSCv371319,040,240 - 19,242,784 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361318,955,836 - 19,158,380 (+)NCBIMGSCv36mm8
Celera1319,259,525 - 19,457,406 (+)NCBICelera
Cytogenetic Map13A2NCBI
cM Map136.89NCBI
Amph
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554604,804,442 - 5,023,202 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554604,804,400 - 5,024,312 (+)NCBIChiLan1.0ChiLan1.0
LOC100995139
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2643,214,846 - 43,461,235 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1791,539,581 - 91,785,970 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0739,015,699 - 39,262,120 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1739,250,081 - 39,495,844 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl739,250,081 - 39,495,844 (-)Ensemblpanpan1.1panPan2
AMPH
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11811,132,078 - 11,261,847 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1811,143,446 - 11,260,841 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1810,903,625 - 11,114,792 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01811,099,548 - 11,310,938 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1811,098,056 - 11,309,936 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11811,076,355 - 11,287,485 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01811,044,639 - 11,263,972 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01811,160,063 - 11,371,410 (+)NCBIUU_Cfam_GSD_1.0
Amph
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440511894,747,942 - 94,972,174 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647813,960,771 - 14,183,764 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647813,959,669 - 14,183,835 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
AMPH
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl9108,799,793 - 108,971,660 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.19108,800,718 - 108,971,575 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.29119,651,630 - 119,751,221 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Amph
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474022,399,244 - 22,614,608 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474022,399,302 - 22,615,736 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

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Variants in Amph
3807 total Variants

Predicted Target Of
Summary Value
Count of predictions:81
Count of miRNA genes:78
Interacting mature miRNAs:81
Transcripts:ENSRNOT00000017102
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


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The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
631497Bp98Blood pressure QTL 983.66arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)174135465160463643Rat
1354581Bp247Blood pressure QTL 2474.5arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)17169599340Rat
1358295Aocep1Aortic cell protein QTL 16.17e-07thoracic aorta cellular protein amount (VT:0010598)aortic cell percentage174099000585990005Rat
1354640Scl32Serum cholesterol level QTL 325.4blood HDL cholesterol amount (VT:0000184)blood high density lipoprotein cholesterol level (CMO:0000052)171578159260781592Rat
152023626Bp403Blood pressure QTL 4033.86arterial blood pressure trait (VT:2000000)172393042179524188Rat
2301412Kidm40Kidney mass QTL 400.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)173747984782479847Rat
9590107Sffal7Serum free fatty acids level QTL 74.810.001blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)172840914773409147Rat
2302377Scl61Serum cholesterol level QTL 614.36blood HDL cholesterol amount (VT:0000184)serum high density lipoprotein cholesterol level (CMO:0000361)172738994653481766Rat
70157Niddm32Non-insulin dependent diabetes mellitus QTL 324.34blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)172245492450909196Rat
724549Niddm56Non-insulin dependent diabetes mellitus QTL 560.03blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)173199078476990784Rat

1 to 10 of 48 rows
RH131007  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2863,318,169 - 63,318,360 (+)MAPPERmRatBN7.2
mRatBN7.21745,886,101 - 45,886,303 (+)MAPPERmRatBN7.2
Rnor_6.01748,455,564 - 48,455,765NCBIRnor6.0
Rnor_6.0867,747,980 - 67,748,170NCBIRnor6.0
Rnor_5.01746,508,844 - 46,509,045UniSTSRnor5.0
Rnor_5.0867,476,727 - 67,476,917UniSTSRnor5.0
RGSC_v3.4867,001,823 - 67,002,013UniSTSRGSC3.4
RGSC_v3.41753,705,754 - 53,705,955UniSTSRGSC3.4
Celera1741,984,143 - 41,984,344UniSTS
Celera862,733,083 - 62,733,273UniSTS
Cytogenetic Map17q11UniSTS
Cytogenetic Map8q24UniSTS




alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
6 9 49 113 49 48 19 22 19 6 170 92 93 45 60 29



Ensembl Acc Id: ENSRNOT00000017102   ⟹   ENSRNOP00000017102
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1745,739,395 - 45,983,315 (-)Ensembl
Rnor_6.0 Ensembl1748,304,322 - 48,562,838 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000080800   ⟹   ENSRNOP00000073615
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1745,739,395 - 45,982,989 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000084702   ⟹   ENSRNOP00000070116
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1745,739,395 - 45,983,315 (-)Ensembl
Rnor_6.0 Ensembl1748,304,329 - 48,562,905 (-)Ensembl
RefSeq Acc Id: NM_022217   ⟹   NP_071553
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81750,435,018 - 50,678,501 (-)NCBI
mRatBN7.21745,739,385 - 45,982,883 (-)NCBI
Rnor_6.01748,304,324 - 48,562,838 (-)NCBI
Rnor_5.01746,357,604 - 46,621,763 (-)NCBI
RGSC_v3.41753,558,804 - 53,802,936 (-)RGD
Sequence:
RefSeq Acc Id: XM_039096040   ⟹   XP_038951968
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81750,435,018 - 50,581,884 (-)NCBI
mRatBN7.21745,739,385 - 45,886,191 (-)NCBI
RefSeq Acc Id: XM_039096041   ⟹   XP_038951969
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81750,435,018 - 50,678,583 (-)NCBI
mRatBN7.21745,739,385 - 45,982,905 (-)NCBI
RefSeq Acc Id: XM_039096042   ⟹   XP_038951970
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81750,435,018 - 50,678,494 (-)NCBI
mRatBN7.21745,739,385 - 45,982,867 (-)NCBI
RefSeq Acc Id: XM_063276719   ⟹   XP_063132789
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81750,435,018 - 50,678,571 (-)NCBI
1 to 10 of 10 rows
Protein RefSeqs NP_071553 (Get FASTA)   NCBI Sequence Viewer  
  XP_038951968 (Get FASTA)   NCBI Sequence Viewer  
  XP_038951969 (Get FASTA)   NCBI Sequence Viewer  
  XP_038951970 (Get FASTA)   NCBI Sequence Viewer  
  XP_063132789 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein CAA73808 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000017102
  ENSRNOP00000070116
  ENSRNOP00000073615
GenBank Protein O08838 (Get FASTA)   NCBI Sequence Viewer  
1 to 10 of 10 rows
RefSeq Acc Id: NP_071553   ⟸   NM_022217
- UniProtKB: O08838 (UniProtKB/Swiss-Prot)
- Sequence:
Ensembl Acc Id: ENSRNOP00000070116   ⟸   ENSRNOT00000084702
Ensembl Acc Id: ENSRNOP00000017102   ⟸   ENSRNOT00000017102
RefSeq Acc Id: XP_038951969   ⟸   XM_039096041
- Peptide Label: isoform X2
- UniProtKB: O08838 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_038951970   ⟸   XM_039096042
- Peptide Label: isoform X3
- UniProtKB: O08838 (UniProtKB/Swiss-Prot)
BAR   SH3

Name Modeler Protein Id AA Range Protein Structure
AF-A0A0G2K5Z4-F1-model_v2 AlphaFold A0A0G2K5Z4 1-614 view protein structure
AF-O08838-F1-model_v2 AlphaFold O08838 1-683 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13700504
Promoter ID:EPDNEW_R11028
Type:initiation region
Name:Amph_1
Description:amphiphysin
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01748,562,914 - 48,562,974EPDNEW


1 to 40 of 42 rows
Database
Acc Id
Source(s)
BIND 130419
  130420
  130421
  134465
  144371
BioCyc Gene G2FUF-9132 BioCyc
Ensembl Genes ENSRNOG00000012490 Ensembl
  ENSRNOG00000059510 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000017102 ENTREZGENE
  ENSRNOT00000080800 ENTREZGENE
  ENSRNOT00000084702 ENTREZGENE
Gene3D-CATH 1.20.1270.60 UniProtKB/Swiss-Prot
  SH3 Domains UniProtKB/Swiss-Prot
InterPro AH/BAR_dom_sf UniProtKB/Swiss-Prot
  Amphiphysin UniProtKB/Swiss-Prot
  Amphiphysin_1 UniProtKB/Swiss-Prot
  Amphiphysin_I_SH3 UniProtKB/Swiss-Prot
  BAR_dom UniProtKB/Swiss-Prot
  SH3-like_dom_sf UniProtKB/Swiss-Prot
  SH3_domain UniProtKB/Swiss-Prot
KEGG Report rno:60668 UniProtKB/Swiss-Prot
NCBI Gene 60668 ENTREZGENE
PANTHER AMPHIPHYSIN UniProtKB/Swiss-Prot
  PTHR46514:SF2 UniProtKB/Swiss-Prot
Pfam BAR UniProtKB/Swiss-Prot
PhenoGen Amph PhenoGen
PRINTS AMPHIPHYSIN UniProtKB/Swiss-Prot
  AMPHIPHYSIN1 UniProtKB/Swiss-Prot
  SH3DOMAIN UniProtKB/Swiss-Prot
PROSITE BAR UniProtKB/Swiss-Prot
  SH3 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000012490 RatGTEx
  ENSRNOG00000059510 RatGTEx
SMART BAR UniProtKB/Swiss-Prot
  SH3 UniProtKB/Swiss-Prot
Superfamily-SCOP SSF103657 UniProtKB/Swiss-Prot
  SSF50044 UniProtKB/Swiss-Prot
UniProt A0A0G2JX32 ENTREZGENE, UniProtKB/TrEMBL
  A0A0G2K5Z4 ENTREZGENE, UniProtKB/TrEMBL
  AMPH_RAT UniProtKB/Swiss-Prot
1 to 40 of 42 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-03-09 Amph  amphiphysin  LOC100909679  amphiphysin-like  Data merged from RGD:6502395 737654 PROVISIONAL
2013-04-17 Amph  amphiphysin  LOC687233  similar to amphiphysin 1  Data merged from RGD:1587745 737654 PROVISIONAL
2012-07-05 LOC100909679  amphiphysin-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2008-02-22 Amph  amphiphysin  Amph1  amphiphysin 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-11-19 LOC687233  similar to amphiphysin 1      Symbol and Name status set to provisional 70820 PROVISIONAL
2005-01-20 Amph1  amphiphysin 1    amphiphysin  Symbol updated 1299863 APPROVED
2002-08-07 Amph1  amphiphysin      Symbol and Name status set to provisional 70820 PROVISIONAL

Note Type Note Reference
gene_domains contains a src homology 3 domain 631926
gene_physical_interaction forms a heterodimer with Amph2 that activates dynamin GTPase activity 631926