S100a8 (S100 calcium binding protein A8) - Rat Genome Database

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Gene: S100a8 (S100 calcium binding protein A8) Rattus norvegicus
Analyze
Symbol: S100a8
Name: S100 calcium binding protein A8
RGD ID: 620265
Description: Predicted to enable calcium ion binding activity and calcium-dependent protein binding activity. Involved in several processes, including autocrine signaling; response to ethanol; and response to lipopolysaccharide. Located in extracellular space. Biomarker of urinary bladder cancer. Human ortholog(s) of this gene implicated in myocarditis. Orthologous to human S100A8 (S100 calcium binding protein A8); INTERACTS WITH (S)-colchicine; 1,2-dimethylhydrazine; 1-naphthyl isothiocyanate.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: calgranulin-A; migration inhibitory factor-related protein 8; MRP-8; Mrp8; p8; protein S100-A8; S100 calcium binding protein A8 (calgranulin A); S100 calcium-binding protein A8; S100 calcium-binding protein A8 (calgranulin A)
RGD Orthologs
Human
Mouse
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82178,464,095 - 178,465,223 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl2178,464,702 - 178,465,221 (+)EnsemblGRCr8
mRatBN7.22176,166,517 - 176,167,645 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2176,167,124 - 176,167,643 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx2183,307,416 - 183,307,935 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02181,329,670 - 181,330,189 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02175,929,499 - 175,930,018 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.02190,073,239 - 190,074,333 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2190,073,815 - 190,074,354 (+)Ensemblrn6Rnor6.0
Rnor_5.02209,507,598 - 209,508,692 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.42182,961,994 - 182,962,513 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera2170,099,876 - 170,100,395 (+)NCBICelera
RGSC_v3.12182,912,099 - 182,912,619 (+)NCBI
Cytogenetic Map2q34NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
(R)-noradrenaline  (ISO)
(S)-colchicine  (EXP)
1,2-dimethylhydrazine  (EXP)
1,4-dichlorobenzene  (ISO)
1-naphthyl isothiocyanate  (EXP)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (EXP)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-trinitrobenzenesulfonic acid  (ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
5-aza-2'-deoxycytidine  (ISO)
6-propyl-2-thiouracil  (EXP,ISO)
7,12-dimethyltetraphene  (EXP,ISO)
9-cis-retinoic acid  (ISO)
acetamide  (EXP)
acrylonitrile  (ISO)
Actein  (EXP)
aflatoxin B1  (ISO)
alachlor  (EXP)
aldehydo-D-glucose  (ISO)
all-trans-4-oxoretinoic acid  (ISO)
all-trans-retinoic acid  (ISO)
allopurinol  (EXP)
aluminium oxide  (ISO)
ammonium chloride  (EXP)
antirheumatic drug  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
aspartame  (ISO)
astemizole  (EXP)
azathioprine  (ISO)
benzo[a]pyrene  (ISO)
benzo[b]fluoranthene  (ISO)
Benzo[k]fluoranthene  (ISO)
beta-naphthoflavone  (EXP,ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
bleomycin A2  (EXP)
buta-1,3-diene  (ISO)
butan-1-ol  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
calcitriol  (ISO)
calcium atom  (ISO)
calcium dichloride  (ISO)
calcium(0)  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
carnosic acid  (ISO)
CGP 52608  (ISO)
chloroform  (EXP)
chloropicrin  (ISO)
chloroprene  (ISO)
chlorothalonil  (ISO)
cholesterol  (EXP)
choline  (EXP,ISO)
cisplatin  (ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
corn oil  (EXP)
Cuprizon  (EXP)
curcumin  (ISO)
cyanocob(III)alamin  (ISO)
cyclosporin A  (ISO)
cypermethrin  (ISO)
cyproconazole  (ISO)
D-glucose  (ISO)
D-penicillamine  (EXP)
dantrolene  (ISO)
decabromodiphenyl ether  (EXP)
dexamethasone  (ISO)
dextran sulfate  (ISO)
diarsenic trioxide  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (EXP)
dichloroacetic acid  (ISO)
diclofenac  (ISO)
dicloxacillin  (ISO)
diethylstilbestrol  (ISO)
diiodine  (ISO)
dimethyl sulfoxide  (ISO)
dimethylarsinous acid  (ISO)
dioxygen  (EXP)
dipotassium bis[mu-tartrato(4-)]diantimonate(2-) trihydrate  (ISO)
disodium selenite  (ISO)
diuron  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
doxycycline  (ISO)
endosulfan  (ISO)
epoxiconazole  (ISO)
erythromycin estolate  (EXP)
ethanol  (EXP,ISO)
fentanyl  (EXP)
flucloxacillin  (ISO)
flutamide  (ISO)
folic acid  (EXP,ISO)
fragrance  (ISO)
gadolinium trichloride  (EXP)
gefitinib  (ISO)
gemfibrozil  (ISO)
genistein  (ISO)
gentamycin  (EXP)
glafenine  (EXP)
glucose  (ISO)
glycine betaine  (ISO)
graphene oxide  (ISO)
halothane  (ISO)
hexachlorobenzene  (EXP)
hydralazine  (ISO)
indinavir  (ISO)
isobutanol  (ISO)
isoflavones  (EXP)
isoprenaline  (ISO)
isotretinoin  (ISO)
L-methionine  (EXP,ISO)
lamivudine  (ISO)
lead diacetate  (ISO)
lidocaine  (EXP,ISO)
lipopolysaccharide  (ISO)
lovastatin  (ISO)
maneb  (ISO)
mebendazole  (ISO)
mercury dichloride  (ISO)
metacetamol  (ISO)
methapyrilene  (EXP,ISO)
methimazole  (EXP)
methylmercury chloride  (EXP)
methylparaben  (ISO)
Miglitol  (EXP)
Moniliformin  (ISO)
monosodium L-glutamate  (ISO)
N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine  (ISO)
N-methyl-4-phenylpyridinium  (EXP)
N-nitrosodiethylamine  (EXP)
N-Nitrosopyrrolidine  (ISO)
naphthalene  (ISO)
nickel atom  (ISO)
nickel sulfate  (ISO)
nitrofen  (EXP)
ozone  (EXP,ISO)
paracetamol  (EXP,ISO)
paraquat  (ISO)
pentanal  (ISO)
perfluorodecanoic acid  (ISO)
perfluoroheptanoic acid  (ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorohexanoic acid  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
phenacetin  (EXP)
phenanthrene  (ISO)
phenobarbital  (ISO)
phenylhydrazine  (EXP)
phenytoin  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
pioglitazone  (ISO)
pirinixic acid  (ISO)
platycodin D  (ISO)
potassium bromate  (EXP)
pregnenolone 16alpha-carbonitrile  (ISO)
primidone  (ISO)
progesterone  (ISO)
propanal  (ISO)
propiconazole  (ISO)
pyridaben  (ISO)
reactive oxygen species  (ISO)
Rebamipide  (EXP)
resveratrol  (EXP)
ryanodine  (ISO)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (EXP,ISO)
saquinavir  (ISO)
SB 431542  (ISO)
silicon dioxide  (EXP,ISO)
simvastatin  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (EXP,ISO)
sodium cholate  (EXP)
sodium dichromate  (EXP)
streptozocin  (ISO)
succimer  (ISO)
sulforaphane  (ISO)
tamibarotene  (ISO)
tamoxifen  (ISO)
testosterone  (EXP,ISO)
tetrachloromethane  (EXP,ISO)
tetracycline  (EXP)
tetrathiomolybdate(2-)  (ISO)
thioacetamide  (EXP)
thiram  (ISO)
titanium dioxide  (EXP,ISO)
tremolite asbestos  (ISO)
triadimefon  (ISO)
tributylstannane  (ISO)
trichloroethene  (EXP,ISO)
triclosan  (ISO)
triphenyl phosphate  (ISO)
troglitazone  (ISO)
tungsten  (ISO)
valproic acid  (ISO)
vincaleukoblastine  (EXP)
vinclozolin  (EXP)
vincristine  (EXP,ISO)
vitamin D  (EXP)
XL147  (ISO)
zidovudine  (ISO)
zinc atom  (EXP,ISO)
zinc(0)  (EXP,ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. Expression and cloning of migration inhibitory factor-related protein (MRP)8 and MRP14 in arthritis-susceptible rats. Imamichi T, etal., Biochem Biophys Res Commun 1993 Jul 30;194(2):819-25.
4. Elucidating the molecular physiopathology of acute respiratory distress syndrome in severe acute respiratory syndrome patients. Kong SL, etal., Virus Res. 2009 Nov;145(2):260-9. Epub 2009 Jul 25.
5. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
6. CD68 on rat macrophages binds tightly to S100A8 and S100A9 and helps to regulate the cells' immune functions. Okada K, etal., J Leukoc Biol. 2016 Nov;100(5):1093-1104. doi: 10.1189/jlb.2A0415-170RRR. Epub 2016 Jun 16.
7. Suppression of inflammation in rat autoimmune myocarditis by S100A8/A9 through modulation of the proinflammatory cytokine network. Otsuka K, etal., Eur J Heart Fail. 2009 Mar;11(3):229-37. Epub 2009 Jan 16.
8. Identification of posttranslational modifications and cDNA sequencing errors in the rat S100 proteins MRP8 and 14 using electrospray ionization mass spectrometry. Raftery MJ and Geczy CL, Anal Biochem 1998 May 1;258(2):285-92.
9. FGF-2, IL-1beta and TGF-beta regulate fibroblast expression of S100A8. Rahimi F, etal., FEBS J. 2005 Jun;272(11):2811-27.
10. GOA pipeline RGD automated data pipeline
11. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
12. Comprehensive gene review and curation RGD comprehensive gene curation
13. PSMD11, PTPRM and PTPRB as novel biomarkers of pancreatic cancer progression. Sahni S, etal., Biochim Biophys Acta Gen Subj. 2020 Nov;1864(11):129682. doi: 10.1016/j.bbagen.2020.129682. Epub 2020 Jul 12.
14. Two-dimensional electrophoresis protein profiling and identification in rat bronchoalveolar lavage fluid following allergen and endotoxin challenge. Signor L, etal., Proteomics. 2004 Jul;4(7):2101-10.
15. Zinc replenishment reverses overexpression of the proinflammatory mediator S100A8 and esophageal preneoplasia in the rat. Taccioli C, etal., Gastroenterology. 2009 Mar;136(3):953-66. Epub 2008 Nov 24.
16. Expression of S100 protein family members in the pathogenesis of bladder tumors. Yao R, etal., Anticancer Res. 2007 Sep-Oct;27(5A):3051-8.
17. Alcohol intoxication inhibits pulmonary S100A8 and S100A9 expression in rats challenged with intratracheal lipopolysaccharide. Zhang P, etal., Alcohol Clin Exp Res. 2007 Jan;31(1):113-21.
Additional References at PubMed
PMID:1299962   PMID:12626582   PMID:16502470   PMID:18063312   PMID:18820689   PMID:19056867   PMID:19199708   PMID:19667050   PMID:19935772   PMID:21630459   PMID:21805676   PMID:21887593  
PMID:22381691   PMID:22577135   PMID:22664934   PMID:23376485   PMID:23533145   PMID:23982744   PMID:25417112   PMID:25485702   PMID:25820336   PMID:26920052   PMID:27035526   PMID:27068509  
PMID:28088518   PMID:28161820   PMID:28913572   PMID:36299239   PMID:36634215   PMID:37219522   PMID:38697446   PMID:39111720   PMID:39390946  


Genomics

Comparative Map Data
S100a8
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82178,464,095 - 178,465,223 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl2178,464,702 - 178,465,221 (+)EnsemblGRCr8
mRatBN7.22176,166,517 - 176,167,645 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2176,167,124 - 176,167,643 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx2183,307,416 - 183,307,935 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02181,329,670 - 181,330,189 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02175,929,499 - 175,930,018 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.02190,073,239 - 190,074,333 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2190,073,815 - 190,074,354 (+)Ensemblrn6Rnor6.0
Rnor_5.02209,507,598 - 209,508,692 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.42182,961,994 - 182,962,513 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera2170,099,876 - 170,100,395 (+)NCBICelera
RGSC_v3.12182,912,099 - 182,912,619 (+)NCBI
Cytogenetic Map2q34NCBI
S100A8
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381153,390,032 - 153,422,583 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1153,390,032 - 153,391,142 (-)Ensemblhg38GRCh38
GRCh371153,362,508 - 153,395,059 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361151,629,132 - 151,630,173 (-)NCBIBuild 36Build 36hg18NCBI36
Build 341150,175,581 - 150,176,622NCBI
Celera1126,433,763 - 126,434,804 (-)NCBICelera
Cytogenetic Map1q21.3NCBI
HuRef1124,725,919 - 124,727,075 (-)NCBIHuRef
CHM1_11154,758,221 - 154,759,377 (-)NCBICHM1_1
T2T-CHM13v2.01152,527,256 - 152,559,808 (-)NCBIT2T-CHM13v2.0
S100a8
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39390,576,378 - 90,577,341 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl390,576,285 - 90,577,342 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38390,669,071 - 90,670,034 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl390,668,978 - 90,670,035 (+)Ensemblmm10GRCm38
MGSCv37390,472,993 - 90,473,956 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36390,755,012 - 90,755,961 (+)NCBIMGSCv36mm8
Celera390,710,479 - 90,711,442 (+)NCBICelera
Cytogenetic Map3F1NCBI
cM Map339.9NCBI
S100A8
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2196,446,588 - 96,447,727 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1196,182,294 - 96,183,433 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01128,741,378 - 128,742,520 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11132,370,435 - 132,371,591 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1132,370,435 - 132,371,591 (-)EnsemblpanPan2panpan1.1
S100A8
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1743,540,667 - 43,541,604 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl743,501,989 - 43,541,604 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha743,033,549 - 43,034,484 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0743,490,339 - 43,491,275 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl743,451,730 - 43,491,276 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1743,192,654 - 43,193,589 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0743,246,467 - 43,247,402 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0743,530,107 - 43,531,042 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
S100a8
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505824,226,017 - 24,226,645 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365803,256,417 - 3,256,913 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365803,256,399 - 3,256,913 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
S100A8
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl496,209,659 - 96,210,602 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1496,209,670 - 96,210,603 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.24105,091,816 - 105,092,749 (-)NCBISscrofa10.2Sscrofa10.2susScr3
S100A8
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12010,363,142 - 10,364,293 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2010,363,287 - 10,364,317 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_0236660389,831,912 - 9,833,063 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
S100a8
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_004624885784,528 - 785,623 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
S100a8
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1362,941,873 - 62,942,388 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in S100a8
10 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:75
Count of miRNA genes:68
Interacting mature miRNAs:75
Transcripts:ENSRNOT00000015473
Prediction methods:Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1358356Srcrt1Stress Responsive Cort QTL13.66blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)2163997722225110681Rat
1578648Bss11Bone structure and strength QTL 114.7femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)2169358774214358774Rat
1331734Bp204Blood pressure QTL 2043.61192arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2170656145239614549Rat
631566Bp90Blood pressure QTL 900.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2149957381221199885Rat
1298074Bp164Blood pressure QTL 1640.003arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)244537979205135428Rat
1354648Bp239Blood pressure QTL 2390.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)267845370229470703Rat
1354649Kidm17Kidney mass QTL 172.9kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)283465462229820014Rat
10755499Bp389Blood pressure QTL 3892.61arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)220695736231474293Rat
1298076Bp166Blood pressure QTL 1660.0009arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2138595962205135428Rat
1581576Pur7Proteinuria QTL 70.0001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)280396178220931218Rat
152025245Scl81Serum cholesterol level QTL 813.49blood cholesterol amount (VT:0000180)2124537199209621565Rat
1581578Cm49Cardiac mass QTL 494.90.01heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)2145807215220931416Rat
631198Cm22Cardiac mass QTL 224.30.0008heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)278269809208420281Rat
1554319Bmd2Bone mineral density QTL 213.40.0001lumbar vertebra area (VT:0010570)lumbar vertebra cross-sectional area (CMO:0001689)2122597372215234002Rat
12879836Kidm61Kidney mass QTL 610.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)2154723085199723085Rat
1581569Uae32Urinary albumin excretion QTL 320.0001urine protein amount (VT:0005160)urine albumin excretion rate (CMO:0000757)280396178220931218Rat
10043136Iddm54Insulin dependent diabetes mellitus QTL 543.40.0001blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)2145807215190807215Rat
12879837Am2Aortic mass QTL 20.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)2154723085199723085Rat
10043139Iddm55Insulin dependent diabetes mellitus QTL 553.10.0001blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)2150313808195313808Rat
12879838Cm86Cardiac mass QTL 860.002heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)2154723085199723085Rat
1302793Bw16Body weight QTL 1650.0001body mass (VT:0001259)body weight (CMO:0000012)2159440891205135267Rat
12879839Cm85Cardiac mass QTL 850.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)2154723085199723085Rat
1549833Bp257Blood pressure QTL 2570.003arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2170652929215652929Rat
1358900Bw48Body weight QTL 484.88body mass (VT:0001259)body weight (CMO:0000012)2159440891220931218Rat
4889834Pur24Proteinuria QTL 245.80.014urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)2171994826205135428Rat
1359030Bp277Blood pressure QTL 277arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)2143565208188565208Rat
1331760Bp206Blood pressure QTL 2063.62454arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)24265106205135428Rat
12879840Bw179Body weight QTL 1790.005body mass (VT:0001259)body weight (CMO:0000012)2154723085199723085Rat
1581502Esta3Estrogen-induced thymic atrophy QTL 3thymus mass (VT:0004954)thymus wet weight (CMO:0000855)2139067258192287892Rat
1359032Hrtrt18Heart rate QTL 18heart pumping trait (VT:2000009)heart rate (CMO:0000002)2159440760195313808Rat
2301966Bp322Blood pressure QTL 3223.58arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2144882354205135428Rat
1298080Bp163Blood pressure QTL 1630.02arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)267845182205135428Rat
1357991Ael2Aortic elastin QTL 24.20.000071aorta elastin amount (VT:0003905)aortic elastin2169227906214227906Rat
8662832Vetf7Vascular elastic tissue fragility QTL 73.5aorta elastin amount (VT:0003905)aorta wall extracellular elastin dry weight to aorta wall dry weight ratio (CMO:0002002)283400752223709938Rat
1298085Bp165Blood pressure QTL 1650.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)244537979205135428Rat
1578671Bmd10Bone mineral density QTL 105.4femur mineral mass (VT:0010011)compact volumetric bone mineral density (CMO:0001730)2175931416220931416Rat
1359022Ppulsi1Prepulse inhibition QTL 13.63prepulse inhibition trait (VT:0003088)acoustic startle response measurement (CMO:0001519)2139067258184067258Rat
1641891Alcrsp17Alcohol response QTL 17response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)2151869660251712708Rat
724534Uae6Urinary albumin excretion QTL 610urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)280396034220931416Rat
61374Edpm2Estrogen-dependent pituitary mass QTL 24.420.86pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)278269809205135428Rat
8662843Vetf9Vascular elastic tissue fragility QTL 92.05thoracic aorta molecular composition trait (VT:0010568)aorta wall extracellular elastin dry weight to aorta wall extracellular collagen weight ratio (CMO:0002003)2159440760228950743Rat
1331794Bp202Blood pressure QTL 2023.66819arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2143344967251712708Rat
71113Cari2Carrageenan-induced inflammation QTL 22.70.009hypodermis integrity trait (VT:0010550)inflammatory exudate volume (CMO:0001429)2143746578205135428Rat
1331805Cm29Cardiac mass QTL 293.50746heart mass (VT:0007028)heart wet weight (CMO:0000069)2143344967251712708Rat
634308Sach6Saccharin preference QTL 64.9taste sensitivity trait (VT:0001986)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)2114384617215381366Rat
1598805Memor8Memory QTL 83exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)2150096616195096616Rat
1358917Cm42Cardiac mass QTL 422.82heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)227148328206613235Rat
724568Uae13Urinary albumin excretion QTL 134.4urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)2145306936212705578Rat
1358913Cm41Cardiac mass QTL 412.73heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)227148328206613235Rat
1300165Rf9Renal function QTL 93.28kidney glomerulus integrity trait (VT:0010546)index of glomerular damage (CMO:0001135)2113746222205135428Rat
61401Niddm2Non-insulin dependent diabetes mellitus QTL 24.54blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)2147287892192287892Rat
631507Bp105Blood pressure QTL 1050.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2114384617215381366Rat
1641925Alcrsp2Alcohol response QTL 2response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)2151869660223841096Rat
1354609Niddm62Non-insulin dependent diabetes mellitus QTL 624.720.000006insulin secretion trait (VT:0003564)plasma insulin level (CMO:0000342)2117415288205135428Rat
1598833Bp295Blood pressure QTL 2953.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2150096616195096616Rat
1354622Kidm16Kidney mass QTL 163kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)283465462225110681Rat
631266Bp132Blood pressure QTL 1320.0005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)247856345205135428Rat
631522Bp74Blood pressure QTL 740.05arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2175008837220008837Rat
7488927Bp365Blood pressure QTL 3650.008arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2165453811210453811Rat
7488925Bp364Blood pressure QTL 3640.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2163253030208253030Rat
2293843Kiddil6Kidney dilation QTL 63.1kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)244537979184731399Rat
2306901Bp337Blood pressure QTL 3370.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2166372086229820014Rat
1354605Rf48Renal function QTL 482.9blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)276328396209350714Rat

Markers in Region
AI323541  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22176,167,157 - 176,167,242 (+)MAPPERmRatBN7.2
Rnor_6.02190,073,846 - 190,073,930NCBIRnor6.0
Rnor_5.02209,508,205 - 209,508,289UniSTSRnor5.0
RGSC_v3.42182,962,028 - 182,962,112UniSTSRGSC3.4
Celera2170,099,908 - 170,099,992UniSTS
Cytogenetic Map2q34UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
15 10 61 139 89 90 59 92 59 6 331 179 11 110 70 76 31 8 8

Sequence


Ensembl Acc Id: ENSRNOT00000015473   ⟹   ENSRNOP00000015473
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl2178,464,702 - 178,465,221 (+)Ensembl
mRatBN7.2 Ensembl2176,167,124 - 176,167,643 (+)Ensembl
Rnor_6.0 Ensembl2190,073,815 - 190,074,354 (+)Ensembl
RefSeq Acc Id: NM_053822   ⟹   NP_446274
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82178,464,704 - 178,465,223 (+)NCBI
mRatBN7.22176,167,126 - 176,167,645 (+)NCBI
Rnor_6.02190,073,814 - 190,074,333 (+)NCBI
Rnor_5.02209,507,598 - 209,508,692 (+)NCBI
RGSC_v3.42182,961,994 - 182,962,513 (+)RGD
Celera2170,099,876 - 170,100,395 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006232565   ⟹   XP_006232627
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82178,464,095 - 178,465,223 (+)NCBI
mRatBN7.22176,166,517 - 176,167,645 (+)NCBI
Rnor_6.02190,073,239 - 190,074,333 (+)NCBI
Rnor_5.02209,507,598 - 209,508,692 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_446274 (Get FASTA)   NCBI Sequence Viewer  
  XP_006232627 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA41637 (Get FASTA)   NCBI Sequence Viewer  
  EDM00536 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000015473
  ENSRNOP00000015473.1
GenBank Protein P50115 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_446274   ⟸   NM_053822
- UniProtKB: P50115 (UniProtKB/Swiss-Prot),   A6J6Q3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006232627   ⟸   XM_006232565
- Peptide Label: isoform X1
- UniProtKB: P50115 (UniProtKB/Swiss-Prot),   A6J6Q3 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000015473   ⟸   ENSRNOT00000015473
Protein Domains
EF-hand

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P50115-F1-model_v2 AlphaFold P50115 1-89 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620265 AgrOrtholog
BioCyc Gene G2FUF-52324 BioCyc
Ensembl Genes ENSRNOG00000011557 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000015473 ENTREZGENE
  ENSRNOT00000015473.4 UniProtKB/Swiss-Prot
Gene3D-CATH EF-hand UniProtKB/Swiss-Prot
InterPro EF-hand-dom_pair UniProtKB/Swiss-Prot
  EF_Hand_1_Ca_BS UniProtKB/Swiss-Prot
  EF_hand_dom UniProtKB/Swiss-Prot
  S100/CaBP-9k_CS UniProtKB/Swiss-Prot
  S100_Ca-bd_sub UniProtKB/Swiss-Prot
KEGG Report rno:116547 UniProtKB/Swiss-Prot
NCBI Gene 116547 ENTREZGENE
PANTHER PTHR11639:SF5 UniProtKB/Swiss-Prot
  S100 CALCIUM-BINDING PROTEIN UniProtKB/Swiss-Prot
Pfam S_100 UniProtKB/Swiss-Prot
PharmGKB S100A8 RGD
PhenoGen S100a8 PhenoGen
PROSITE EF_HAND_1 UniProtKB/Swiss-Prot
  EF_HAND_2 UniProtKB/Swiss-Prot
  S100_CABP UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000011557 RatGTEx
SMART S_100 UniProtKB/Swiss-Prot
Superfamily-SCOP SSF47473 UniProtKB/Swiss-Prot
UniProt A6J6Q3 ENTREZGENE, UniProtKB/TrEMBL
  P50115 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-09-18 S100a8  S100 calcium binding protein A8  S100a8  S100 calcium binding protein A8 (calgranulin A)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-09-10 S100a8  S100 calcium binding protein A8 (calgranulin A)    S100 calcium-binding protein A8 (calgranulin A)  Name updated 1299863 APPROVED
2002-08-07 S100a8  S100 calcium-binding protein A8 (calgranulin A)      Symbol and Name status set to provisional 70820 PROVISIONAL