Ppat (phosphoribosyl pyrophosphate amidotransferase) - Rat Genome Database

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Gene: Ppat (phosphoribosyl pyrophosphate amidotransferase) Rattus norvegicus
Analyze
Symbol: Ppat
Name: phosphoribosyl pyrophosphate amidotransferase
RGD ID: 620237
Description: Enables amidophosphoribosyltransferase activity and identical protein binding activity. Involved in several processes, including G1/S transition of mitotic cell cycle; L-glutamine catabolic process; and lactation. Biomarker of hepatocellular carcinoma and renal cell carcinoma. Orthologous to human PPAT (phosphoribosyl pyrophosphate amidotransferase); PARTICIPATES IN 2-hydroxyglutaric aciduria pathway; adenine phoshoribosyltransferase deficiency pathway; adenosine monophosphate deaminase deficiency pathway; INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: amidophosphoribosyltransferase; Atase; glutamine phosphoribosylpyrophosphate amidotransferase; GPAT; MGC93251
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81431,570,010 - 31,604,410 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1431,551,388 - 31,604,405 (+)EnsemblGRCr8
mRatBN7.21431,215,741 - 31,250,144 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1431,216,165 - 31,250,144 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1431,593,072 - 31,627,368 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01432,901,403 - 32,935,708 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01431,386,077 - 31,420,375 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Dahl_SR_JrHsd1431,868,204 - 31,902,646 (+)NCBIDahl_SR_JrHsd
Lyon_Normotensive1431,983,734 - 32,018,176 (+)NCBILyon_Normotensive
Lyon_Hypertensive1431,980,808 - 32,015,250 (+)NCBILyon_Hypertensive
F344_StmMcwi1432,004,323 - 32,038,624 (+)NCBIF344_StmMcwi
Rnor_6.01433,580,541 - 33,614,919 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1433,580,541 - 33,614,919 (+)Ensemblrn6Rnor6.0
Rnor_5.01433,371,454 - 33,405,854 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41433,509,364 - 33,543,743 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1430,529,492 - 30,563,868 (+)NCBICelera
RGSC_v3.11433,509,363 - 33,543,743 (+)NCBI
Cytogenetic Map14p11NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-alpha-phellandrene  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2,4-dinitrotoluene  (EXP)
2-bromohexadecanoic acid  (ISO)
2-butoxyethanol  (ISO)
2-methylcholine  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3-chloropropane-1,2-diol  (EXP)
3H-1,2-dithiole-3-thione  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
6-propyl-2-thiouracil  (EXP)
all-trans-retinoic acid  (ISO)
alpha-phellandrene  (ISO)
ammonium chloride  (EXP)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
bromobenzene  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
chlorpyrifos  (ISO)
clofibrate  (ISO)
cobalt dichloride  (ISO)
copper atom  (EXP)
copper(0)  (EXP)
coumestrol  (ISO)
DDE  (ISO)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
dibenz[a,h]anthracene  (ISO)
Dibutyl phosphate  (ISO)
dioxygen  (ISO)
doxorubicin  (ISO)
elemental selenium  (ISO)
Enterolactone  (ISO)
enzyme inhibitor  (ISO)
epoxiconazole  (ISO)
ethyl methanesulfonate  (ISO)
flavonoids  (EXP)
flutamide  (EXP)
folic acid  (ISO)
glutathione  (EXP)
ivermectin  (ISO)
methotrexate  (ISO)
methyl methanesulfonate  (ISO)
nefazodone  (EXP)
okadaic acid  (ISO)
oxaliplatin  (EXP)
paracetamol  (EXP,ISO)
parathion  (ISO)
pentachlorophenol  (ISO)
phenobarbital  (ISO)
phorone  (EXP)
pinosylvin  (ISO)
pirinixic acid  (EXP,ISO)
rotenone  (EXP)
selenium atom  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
tamibarotene  (ISO)
tamoxifen  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
topotecan  (EXP)
trans-pinosylvin  (ISO)
trimellitic anhydride  (ISO)
triphenyl phosphate  (ISO)
valproic acid  (ISO)
vitamin E  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

References

References - curated
# Reference Title Reference Citation
1. Enzymes of the pathway of purine synthesis in the rat mammary gland. Changes in the lactation cycle and the effects of diabetes. Beardsley S, etal., Biochem J. 1988 Mar 1;250(2):395-9.
2. Pediatric neurological syndromes and inborn errors of purine metabolism. Camici M, etal., Neurochem Int. 2010 Feb;56(3):367-78. Epub 2009 Dec 11.
3. Rapid in vivo inactivation by acivicin of CTP synthetase, carbamoyl-phosphate synthetase II, and amidophosphoribosyltransferase in hepatoma. Denton JE, etal., Life Sci. 1982 Mar 29;30(13):1073-80.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
6. Increased rate of de novo purine synthesis and its mechanism in regenerating rat liver. Itakura M, etal., Am J Physiol. 1986 Nov;251(5 Pt 1):G585-90.
7. Malotilate (diisopropyl 1,3-dithiol-2-ylidenemalonate) increases liver de novo purine synthesis and amidophosphoribosyltransferase activity. Itakura M, etal., J Pharmacol Exp Ther. 1986 Jun;237(3):794-8.
8. Rat genomic structure of amidophosphoribosyltransferase, cDNA sequence of aminoimidazole ribonucleotide carboxylase, and cell cycle-dependent expression of these two physically linked genes. Iwahana H, etal., Biochim Biophys Acta 1995 Apr 26;1261(3):369-80.
9. An end-trimming method to amplify adjacent cDNA fragments by PCR. Iwahana H, etal., Biotechniques 1994 Jan;16(1):94-8.
10. Molecular cloning of rat amidophosphoribosyltransferase. Iwahana H, etal., J Biol Chem 1993 Apr 5;268(10):7225-37.
11. Renal hypertrophy in experimental diabetes. The activity of the 'de novo' and salvage pathways of purine synthesis. Kunjara S, etal., Biochem J. 1988 Feb 1;249(3):911-4.
12. Enzymic capacities of purine de Novo and salvage pathways for nucleotide synthesis in normal and neoplastic tissues. Natsumeda Y, etal., Cancer Res. 1984 Jun;44(6):2475-9.
13. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
14. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
15. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
16. Glutamine-phosphoribosylpyrophosphate amidotransferase (amidophosphoribosyltransferase, EC 2.4.2.14) activity in normal, differentiating, and neoplastic kidney. Prajda N, etal., Cancer Res. 1979 Oct;39(10):3909-14.
17. GOA pipeline RGD automated data pipeline
18. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
19. Increased de novo purine synthesis by insulin through selective enzyme induction in primary cultured rat hepatocytes. Tsuchiya M, etal., Am J Physiol. 1990 May;258(5 Pt 1):C841-8.
20. Rat liver glutamine 5-phosphoribosyl-1-pyrophosphate amidotransferase [EC 2.4.2.14]. Purification and properties. Tsuda M, etal., J Biochem. 1979 May;85(5):1347-54.
Additional References at PubMed
PMID:12477932   PMID:15489334  


Genomics

Comparative Map Data
Ppat
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81431,570,010 - 31,604,410 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1431,551,388 - 31,604,405 (+)EnsemblGRCr8
mRatBN7.21431,215,741 - 31,250,144 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1431,216,165 - 31,250,144 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1431,593,072 - 31,627,368 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01432,901,403 - 32,935,708 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01431,386,077 - 31,420,375 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Dahl_SR_JrHsd1431,868,204 - 31,902,646 (+)NCBIDahl_SR_JrHsd
Lyon_Normotensive1431,983,734 - 32,018,176 (+)NCBILyon_Normotensive
Lyon_Hypertensive1431,980,808 - 32,015,250 (+)NCBILyon_Hypertensive
F344_StmMcwi1432,004,323 - 32,038,624 (+)NCBIF344_StmMcwi
Rnor_6.01433,580,541 - 33,614,919 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1433,580,541 - 33,614,919 (+)Ensemblrn6Rnor6.0
Rnor_5.01433,371,454 - 33,405,854 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41433,509,364 - 33,543,743 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1430,529,492 - 30,563,868 (+)NCBICelera
RGSC_v3.11433,509,363 - 33,543,743 (+)NCBI
Cytogenetic Map14p11NCBI
PPAT
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38456,393,362 - 56,435,615 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl456,393,362 - 56,435,616 (-)Ensemblhg38GRCh38
GRCh37457,259,528 - 57,301,781 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36456,954,285 - 56,996,602 (-)NCBIBuild 36Build 36hg18NCBI36
Build 34457,100,458 - 57,142,773NCBI
Celera454,765,911 - 54,808,216 (-)NCBICelera
Cytogenetic Map4q12NCBI
HuRef453,213,663 - 53,255,937 (-)NCBIHuRef
CHM1_1457,294,641 - 57,336,915 (-)NCBICHM1_1
T2T-CHM13v2.0459,881,364 - 59,923,605 (-)NCBIT2T-CHM13v2.0
Ppat
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39577,061,096 - 77,099,425 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl577,061,096 - 77,099,425 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38576,913,249 - 76,951,578 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl576,913,249 - 76,951,578 (-)Ensemblmm10GRCm38
MGSCv37577,342,274 - 77,380,603 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36577,987,920 - 78,026,353 (-)NCBIMGSCv36mm8
Celera574,190,125 - 74,219,445 (-)NCBICelera
Cytogenetic Map5C3.3NCBI
cM Map541.45NCBI
Ppat
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495544714,574,407 - 14,607,416 (+)Ensembl
ChiLan1.0NW_00495544714,552,846 - 14,607,416 (+)NCBIChiLan1.0ChiLan1.0
PPAT
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2373,347,602 - 73,390,036 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1473,553,280 - 73,595,555 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0467,491,407 - 67,533,822 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1474,059,967 - 74,102,002 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl474,059,966 - 74,102,002 (+)EnsemblpanPan2panpan1.1
PPAT
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11348,618,460 - 48,656,164 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1348,620,714 - 48,655,780 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1348,509,175 - 48,546,691 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01349,233,071 - 49,270,374 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1349,207,789 - 49,270,306 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11348,904,984 - 48,942,482 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01348,433,951 - 48,471,441 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01349,380,077 - 49,417,387 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Ppat
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440528527,649,519 - 27,693,748 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493648218,606,124 - 18,648,681 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493648218,606,124 - 18,648,989 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PPAT
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl855,654,377 - 55,701,077 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1855,652,194 - 55,701,077 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2857,820,418 - 57,896,880 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PPAT
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1712,201,434 - 12,242,418 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl712,191,784 - 12,243,488 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366606612,869,154 - 12,912,322 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ppat
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476112,980,513 - 13,019,011 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462476112,980,508 - 13,017,818 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Ppat
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11133,664,751 - 33,698,961 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Ppat
129 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:1313
Count of miRNA genes:350
Interacting mature miRNAs:483
Transcripts:ENSRNOT00000002905
Prediction methods:Microtar, Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631528Scl11Serum cholesterol level QTL 114.9blood cholesterol amount (VT:0000180)blood total cholesterol level (CMO:0000051)141787564536079022Rat
7411573Bw139Body weight QTL 1394.70.001body mass (VT:0001259)body weight gain (CMO:0000420)14140068101Rat
9589814Gluco67Glucose level QTL 674.540.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)14140068101Rat
731183Pia20Pristane induced arthritis QTL 203.55joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)14939329839411170Rat
1300154Bp189Blood pressure QTL 1893.04arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)143123808072970315Rat
70187Pancm5Pancreatic morphology QTL 516.7pancreas mass (VT:0010144)pancreas weight to body weight ratio (CMO:0000630)143067446985041098Rat
2324617Coatc2Coat color QTL 20.001coat/hair pigmentation trait (VT:0010463)pigmented coat/hair area to total coat/hair area ratio (CMO:0001810)143112133339507682Rat
1358296Ael3Aortic elastin QTL 33.70.00051aorta elastin amount (VT:0003905)aortic elastin14862139853621398Rat
61420Pia6Pristane induced arthritis QTL 64.9joint integrity trait (VT:0010548)arthritic paw count (CMO:0001460)141891545442433608Rat
7387267Uae42Urinary albumin excretion QTL 420.61urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)142252151767521517Rat
631839Niddm37Non-insulin dependent diabetes mellitus QTL 373.37blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1411334716100078267Rat
2313397Coatc1Coat color QTL1coat/hair pigmentation trait (VT:0010463)coat/hair color measurement (CMO:0001808)141889519263895192Rat
631262Tcas4Tongue tumor susceptibility QTL 47.29tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)141790672654251504Rat
634352Apr6Acute phase response QTL 63.7blood interleukin-6 amount (VT:0008595)plasma interleukin-6 level (CMO:0001927)14141415516Rat
70204Niddm20Non-insulin dependent diabetes mellitus QTL 205.10.000008blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)14131893212Rat
2302045Pia39Pristane induced arthritis QTL 394.90.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G2a level (CMO:0002116)14862139853621398Rat

Markers in Region
RH141568  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21431,249,660 - 31,249,860 (+)MAPPERmRatBN7.2
Rnor_6.01433,614,458 - 33,614,657NCBIRnor6.0
Rnor_5.01433,405,371 - 33,405,570UniSTSRnor5.0
RGSC_v3.41433,543,282 - 33,543,481UniSTSRGSC3.4
Celera1430,563,407 - 30,563,606UniSTS
RH 3.4 Map14382.98UniSTS
Cytogenetic Map14p11UniSTS
PMC312758P2  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21431,216,183 - 31,216,360 (+)MAPPERmRatBN7.2
Rnor_6.01433,580,984 - 33,581,160NCBIRnor6.0
Rnor_5.01433,371,897 - 33,372,073UniSTSRnor5.0
RGSC_v3.41433,509,807 - 33,509,983UniSTSRGSC3.4
Celera1430,529,935 - 30,530,111UniSTS
Cytogenetic Map14p11UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 91 59 6 355 191 11 144 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000002905   ⟹   ENSRNOP00000002905
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1431,551,388 - 31,604,405 (+)Ensembl
mRatBN7.2 Ensembl1431,216,165 - 31,250,144 (+)Ensembl
Rnor_6.0 Ensembl1433,580,541 - 33,614,919 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000100016   ⟹   ENSRNOP00000087004
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1431,570,426 - 31,604,387 (+)Ensembl
mRatBN7.2 Ensembl1431,216,165 - 31,250,144 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000169394   ⟹   ENSRNOP00000106250
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1431,569,677 - 31,604,405 (+)Ensembl
RefSeq Acc Id: NM_057198   ⟹   NP_476546
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81431,570,010 - 31,604,388 (+)NCBI
mRatBN7.21431,215,741 - 31,250,122 (+)NCBI
Dahl_SR_JrHsd1431,868,204 - 31,902,646 (+)NCBI
Lyon_Normotensive1431,983,734 - 32,018,176 (+)NCBI
Lyon_Hypertensive1431,980,808 - 32,015,250 (+)NCBI
F344_StmMcwi1432,004,323 - 32,038,624 (+)NCBI
Rnor_6.01433,580,541 - 33,614,919 (+)NCBI
Rnor_5.01433,371,454 - 33,405,854 (+)NCBI
RGSC_v3.41433,509,364 - 33,543,743 (+)RGD
Celera1430,529,492 - 30,563,868 (+)RGD
Sequence:
RefSeq Acc Id: XM_039091566   ⟹   XP_038947494
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81431,570,565 - 31,604,410 (+)NCBI
mRatBN7.21431,216,234 - 31,250,144 (+)NCBI
RefSeq Acc Id: NP_476546   ⟸   NM_057198
- UniProtKB: P35433 (UniProtKB/Swiss-Prot),   A6JCX0 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000002905   ⟸   ENSRNOT00000002905
RefSeq Acc Id: XP_038947494   ⟸   XM_039091566
- Peptide Label: isoform X1
- UniProtKB: A0A8I6A2E8 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000087004   ⟸   ENSRNOT00000100016
Ensembl Acc Id: ENSRNOP00000106250   ⟸   ENSRNOT00000169394
Protein Domains
Glutamine amidotransferase type-2

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P35433-F1-model_v2 AlphaFold P35433 1-517 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13699271
Promoter ID:EPDNEW_R9796
Type:single initiation site
Name:Ppat_1
Description:phosphoribosyl pyrophosphate amidotransferase
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R9798  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01433,580,527 - 33,580,587EPDNEW
RGD ID:13699273
Promoter ID:EPDNEW_R9798
Type:initiation region
Name:Ppat_2
Description:phosphoribosyl pyrophosphate amidotransferase
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R9796  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01433,580,995 - 33,581,055EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620237 AgrOrtholog
BioCyc Gene G2FUF-15963 BioCyc
Ensembl Genes ENSRNOG00000002128 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000002905.4 UniProtKB/Swiss-Prot
  ENSRNOT00000100016 ENTREZGENE
  ENSRNOT00000169394 ENTREZGENE
Gene3D-CATH 3.40.50.2020 UniProtKB/Swiss-Prot
  3.60.20.10 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7189259 IMAGE-MGC_LOAD
InterPro GATase_2_dom UniProtKB/Swiss-Prot
  Ntn_hydrolases_N UniProtKB/Swiss-Prot
  PRibTrfase_dom UniProtKB/Swiss-Prot
  PRTase-like UniProtKB/Swiss-Prot
  PurF UniProtKB/Swiss-Prot
  PurF_N UniProtKB/Swiss-Prot
KEGG Report rno:117544 UniProtKB/Swiss-Prot
MGC_CLONE MGC:93251 IMAGE-MGC_LOAD
NCBI Gene 117544 ENTREZGENE
PANTHER AMIDOPHOSPHORIBOSYLTRANSFERASE UniProtKB/Swiss-Prot
Pfam GATase_6 UniProtKB/Swiss-Prot
PharmGKB PPAT RGD
PhenoGen Ppat PhenoGen
PIRSF Amd_phspho_trans UniProtKB/Swiss-Prot
PROSITE GATASE_TYPE_2 UniProtKB/Swiss-Prot
  PUR_PYR_PR_TRANSFER UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000002128 RatGTEx
Superfamily-SCOP SSF53271 UniProtKB/Swiss-Prot
  SSF56235 UniProtKB/Swiss-Prot
UniProt A0A8I6A2E8 ENTREZGENE, UniProtKB/TrEMBL
  A6JCX0 ENTREZGENE, UniProtKB/TrEMBL
  P35433 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-02-26 Ppat  phosphoribosyl pyrophosphate amidotransferase      Symbol and Name status set to approved 625702 APPROVED
2002-08-07 Ppat  phosphoribosyl pyrophosphate amidotransferase      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_expression ubiquitously expressed; enriched in brain, heart, liver, and stomach 633710
gene_protein 517 amino acids; 57.4 kDa 633710