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Gene: Sgk2 (serum/glucocorticoid regulated kinase 2) Rattus norvegicus

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Symbol:

Sgk2

Name:

serum/glucocorticoid regulated kinase 2

RGD ID:

620232

Description:

Predicted to enable potassium channel regulator activity and protein serine/threonine kinase activity. Predicted to be involved in intracellular signal transduction. Predicted to be located in cytoplasm and nucleoplasm. Orthologous to human SGK2 (serum/glucocorticoid regulated kinase 2); INTERACTS WITH 17beta-estradiol; 2,4,6-trinitrotoluene; 2-amino-4,6-dinitrotoluene.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

serine/threonine-protein kinase Sgk2; serum/glucocorticoid-regulated kinase 2; SGK2, serine/threonine kinase 2

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	SGK2 (serum/glucocorticoid regulated kinase 2)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Mus musculus (house mouse):	Sgk2 (serum/glucocorticoid regulated kinase 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Sgk2 (serum/glucocorticoid regulated kinase 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	SGK2 (serum/glucocorticoid regulated kinase 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	SGK2 (serum/glucocorticoid regulated kinase 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Sgk2 (serum/glucocorticoid regulated kinase 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	SGK2 (serum/glucocorticoid regulated kinase 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	SGK2 (serum/glucocorticoid regulated kinase 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Sgk2 (serum/glucocorticoid regulated kinase 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus rattus (black rat):	Sgk2 (serum/glucocorticoid regulated kinase 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Other homologs ²
Homo sapiens (human):	APCDD1 (APC down-regulated 1)	HGNC	OMA
Alliance orthologs ³
Homo sapiens (human):	SGK2 (serum/glucocorticoid regulated kinase 2)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Sgk2 (serum/glucocorticoid regulated kinase 2)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	sgk2a (serum/glucocorticoid regulated kinase 2a)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Saccharomyces cerevisiae (baker's yeast):	YPK1	Alliance	DIOPT (InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)
Saccharomyces cerevisiae (baker's yeast):	YPK1	Alliance	DIOPT (InParanoid\|OrthoInspector\|PANTHER\|SonicParanoid)
Saccharomyces cerevisiae (baker's yeast):	YPK2	Alliance	DIOPT (InParanoid\|OrthoFinder\|OrthoInspector\|SonicParanoid)
Saccharomyces cerevisiae (baker's yeast):	YPK2	Alliance	DIOPT (InParanoid\|OrthoInspector\|SonicParanoid)
Caenorhabditis elegans (roundworm):	sgk-1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Saccharomyces cerevisiae (baker's yeast):	SCH9	Alliance	DIOPT (OrthoFinder\|OrthoInspector\|PANTHER)
Xenopus tropicalis (tropical clawed frog):	sgk2	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB)
Xenopus tropicalis (tropical clawed frog):	sgk2	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PhylomeDB\|SonicParanoid)

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	3	172,063,625 - 172,089,000 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	3	172,063,776 - 172,089,011 (+)	Ensembl				GRCr8
mRatBN7.2	3	151,644,102 - 151,669,480 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	3	151,644,102 - 151,669,480 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	3	155,452,311 - 155,477,655 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	3	163,951,255 - 163,976,603 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	3	161,694,860 - 161,720,202 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	3	159,361,313 - 159,385,843 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	3	159,368,273 - 159,384,775 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	3	165,557,662 - 165,581,916 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	3	153,849,825 - 153,890,111 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	3	150,301,782 - 150,326,821 (+)	NCBI		Celera
RGSC_v3.1	3	153,778,278 - 153,794,932 (+)	NCBI
Cytogenetic Map	3	q42	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

colorectal cancer (ISO)

Experimental Liver Cirrhosis (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(2,4,5-trichlorophenoxy)acetic acid (ISO)

1,1-dichloroethene (ISO)

1,2-dimethylhydrazine (ISO)

17alpha-ethynylestradiol (ISO)

17beta-estradiol (EXP,ISO)

2,3,7,8-tetrachlorodibenzodioxine (ISO)

2,4,6-trinitrotoluene (EXP)

2-amino-4,6-dinitrotoluene (EXP)

3,3',4,4',5-pentachlorobiphenyl (EXP)

3,3',5,5'-tetrabromobisphenol A (ISO)

4,4'-sulfonyldiphenol (ISO)

4-hydroxyphenyl retinamide (ISO)

6-propyl-2-thiouracil (EXP)

aflatoxin B1 (ISO)

aldehydo-D-glucose (ISO)

ammonium chloride (EXP)

ampicillin (ISO)

aristolochic acid A (ISO)

arsane (ISO)

arsenic atom (ISO)

atorvastatin calcium (ISO)

Azoxymethane (ISO)

azoxystrobin (ISO)

barium(0) (ISO)

benzo[a]pyrene (ISO)

Benzo[ghi]perylene (ISO)

beta-naphthoflavone (EXP,ISO)

bis(2-ethylhexyl) phthalate (ISO)

bisphenol A (EXP)

bromobenzene (EXP)

buta-1,3-diene (ISO)

cadmium atom (ISO)

cadmium dichloride (ISO)

captan (ISO)

carbon nanotube (ISO)

CGP 52608 (ISO)

chlorpyrifos (ISO)

chromium(6+) (ISO)

cisplatin (ISO)

clofibrate (ISO)

clothianidin (ISO)

copper(II) sulfate (ISO)

Cuprizon (EXP)

cyclosporin A (ISO)

D-glucose (ISO)

dextran sulfate (ISO)

dichloroacetic acid (ISO)

diclofenac (ISO)

dicrotophos (ISO)

dioxygen (ISO)

diquat (ISO)

dorsomorphin (ISO)

doxorubicin (ISO)

endosulfan (EXP)

fenofibrate (ISO)

fluvastatin (ISO)

glucose (ISO)

glutathione (EXP)

GW 4064 (ISO)

hydrogen peroxide (ISO)

isotretinoin (ISO)

Licochalcone B (ISO)

menadione (ISO)

metformin (EXP)

methylmercury chloride (ISO)

N-methylformamide (ISO)

N-nitrosodiethylamine (EXP)

nickel atom (ISO)

ouabain (ISO)

paracetamol (EXP,ISO)

paraquat (EXP,ISO)

PCB138 (EXP)

perfluorohexanesulfonic acid (ISO)

phenobarbital (ISO)

picoxystrobin (ISO)

pirinixic acid (ISO)

potassium atom (ISO)

pregnenolone 16alpha-carbonitrile (ISO)

propiconazole (ISO)

quinolin-8-ol (ISO)

rifampicin (ISO)

rotenone (ISO)

SB 431542 (ISO)

silicon dioxide (ISO)

simvastatin (ISO)

sodium arsenite (EXP,ISO)

streptozocin (ISO)

tert-butyl hydroperoxide (ISO)

tetrachloroethene (ISO)

tetrachloromethane (ISO)

titanium dioxide (ISO)

tremolite asbestos (ISO)

troglitazone (EXP,ISO)

urethane (ISO)

valproic acid (ISO)

vancomycin (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

intracellular signal transduction (IBA,IEA,ISO)

Cellular Component

cytoplasm (IEA)

nucleoplasm (IEA,ISO)

nucleus (IEA)

Molecular Function

ATP binding (IEA)

kinase activity (IEA)

nucleotide binding (IEA)

potassium channel regulator activity (IBA,IEA,ISO,ISS)

protein binding (ISO)

protein kinase activity (IEA)

protein serine kinase activity (IEA)

protein serine/threonine kinase activity (IBA,IEA,ISO)

transferase activity (IEA)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
3.	Electronic Transfer of LocusLink and RefSeq Data	NCBI rat LocusLink and RefSeq merged data July 26, 2002
4.	GOA pipeline	RGD automated data pipeline
5.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
6.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:12397388	PMID:15057822	PMID:19447520	PMID:20926631

Genomics

Comparative Map Data

Sgk2
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	3	172,063,625 - 172,089,000 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	3	172,063,776 - 172,089,011 (+)	Ensembl				GRCr8
mRatBN7.2	3	151,644,102 - 151,669,480 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	3	151,644,102 - 151,669,480 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	3	155,452,311 - 155,477,655 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	3	163,951,255 - 163,976,603 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	3	161,694,860 - 161,720,202 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	3	159,361,313 - 159,385,843 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	3	159,368,273 - 159,384,775 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	3	165,557,662 - 165,581,916 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	3	153,849,825 - 153,890,111 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	3	150,301,782 - 150,326,821 (+)	NCBI		Celera
RGSC_v3.1	3	153,778,278 - 153,794,932 (+)	NCBI
Cytogenetic Map	3	q42	NCBI

SGK2
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	20	43,559,027 - 43,585,627 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	20	43,558,968 - 43,588,237 (+)	Ensembl			hg38	GRCh38
GRCh37	20	42,187,667 - 42,214,267 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	20	41,621,100 - 41,647,687 (+)	NCBI	Build 36	Build 36	hg18	NCBI36
Build 34	20	41,621,099 - 41,647,686	NCBI
Celera	20	38,895,152 - 38,921,737 (+)	NCBI		Celera
Cytogenetic Map	20	q13.12	NCBI
HuRef	20	38,923,264 - 38,950,126 (+)	NCBI		HuRef
CHM1_1	20	42,091,437 - 42,118,025 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	20	45,292,229 - 45,318,829 (+)	NCBI		T2T-CHM13v2.0

Sgk2
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	2	162,829,249 - 162,856,059 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	2	162,829,250 - 162,856,047 (+)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	2	162,987,327 - 163,014,139 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	2	162,987,330 - 163,014,127 (+)	Ensembl			mm10	GRCm38
MGSCv37	2	162,813,217 - 162,839,863 (+)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	2	162,678,987 - 162,705,568 (+)	NCBI		MGSCv36	mm8
Celera	2	168,934,488 - 168,961,119 (+)	NCBI		Celera
Cytogenetic Map	2	H2	NCBI
cM Map	2	83.93	NCBI

Sgk2
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955445	13,581,145 - 13,625,320 (-)	Ensembl
ChiLan1.0	NW_004955445	13,581,145 - 13,625,320 (-)	NCBI	ChiLan1.0	ChiLan1.0

SGK2
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	21	49,304,906 - 49,331,003 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	20	49,298,365 - 49,324,092 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	20	39,897,338 - 39,924,767 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	20	40,992,171 - 41,018,587 (+)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	20	40,997,536 - 41,018,587 (+)	Ensembl			panPan2	panpan1.1

SGK2
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	24	31,272,395 - 31,294,409 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	24	31,272,493 - 31,294,195 (+)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	24	30,916,070 - 30,938,174 (+)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	24	31,986,104 - 32,001,288 (+)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	24	31,980,261 - 32,001,114 (+)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	24	31,243,810 - 31,265,914 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	24	31,355,174 - 31,377,248 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	24	31,895,633 - 31,917,764 (+)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Sgk2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024408640	180,280,673 - 180,302,503 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936530	3,008,161 - 3,024,218 (-)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936530	3,007,934 - 3,025,552 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

SGK2
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	17	46,188,265 - 46,208,804 (+)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	17	46,188,160 - 46,208,807 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	17	51,626,067 - 51,649,666 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

SGK2
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	2	20,217,768 - 20,245,675 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	2	20,218,420 - 20,246,186 (-)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666050	68,961,022 - 68,988,744 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Sgk2
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624790	10,726,486 - 10,752,235 (-)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624790	10,727,125 - 10,749,060 (-)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Sgk2
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	5	154,969,860 - 154,988,115 (-)	NCBI		Rrattus_CSIRO_v1

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	541
Count of miRNA genes:	281
Interacting mature miRNAs:	361
Transcripts:	ENSRNOT00000041688
Prediction methods:	Microtar, Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
12879876	Bw182	Body weight QTL 182		0.003	body mass (VT:0001259)	body weight (CMO:0000012)	3	141555229	186555229	Rat
2301411	Bp320	Blood pressure QTL 320		0.001	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	3	141555229	186555229	Rat
1582233	Insul10	Insulin level QTL 10	5.4	0.0015	blood insulin amount (VT:0001560)	serum insulin level times blood glucose level (CMO:0002040)	3	133259579	178259579	Rat
1300113	Bp176	Blood pressure QTL 176	3.9		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	3	166376089	177728348	Rat
12879872	Cm97	Cardiac mass QTL 97		0.001	heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	3	141555229	186555229	Rat
12879873	Cm96	Cardiac mass QTL 96		0.001	heart mass (VT:0007028)	heart wet weight to body weight ratio (CMO:0002408)	3	141555229	186555229	Rat
1578653	Vnigr3	Vascular neointimal growth QTL 3	3.1		artery morphology trait (VT:0002191)	artery neointimal hyperplastic lesion area (CMO:0001414)	3	151075912	189428310	Rat
2302373	Gluco39	Glucose level QTL 39	5.01		blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	3	129154923	182114333	Rat
12879874	Cm98	Cardiac mass QTL 98		0.005	heart right ventricle mass (VT:0007033)	heart right ventricle weight to body weight ratio (CMO:0000914)	3	141555229	186555229	Rat
12879875	Kidm64	Kidney mass QTL 64		0.001	kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	3	141555229	186555229	Rat
1298068	Bp167	Blood pressure QTL 167		0.004	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	3	161492708	189428310	Rat
70216	Cm14	Cardiac mass QTL 14	2.1		heart mass (VT:0007028)	heart wet weight (CMO:0000069)	3	51581665	184004958	Rat
8552791	Vie2	Viral induced encephalitis QTL 2	4.1		brain integrity trait (VT:0010579)	encephalitis incidence/prevalence measurement (CMO:0002361)	3	166376089	189428310	Rat
61335	Bp20	Blood pressure QTL 20	3		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	3	161799493	176036425	Rat
1578754	Stresp16	Stress response QTL 16	4	0.001	blood renin amount (VT:0003349)	plasma renin activity level (CMO:0000116)	3	133134628	178134628	Rat
1331726	Bp208	Blood pressure QTL 208	3.129		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	3	161799270	187311134	Rat
1582213	Insul6	Insulin level QTL 6	3.7	0.0009	blood insulin amount (VT:0001560)	calculated serum insulin level (CMO:0000359)	3	155759447	189428310	Rat
1598854	Memor10	Memory QTL 10	2		exploratory behavior trait (VT:0010471)	average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)	3	166376089	189428310	Rat
9589106	Insul23	Insulin level QTL 23	13.86	0.001	blood insulin amount (VT:0001560)	plasma insulin level (CMO:0000342)	3	152055202	189428310	Rat
10755461	Coatc16	Coat color QTL 16			coat/hair pigmentation trait (VT:0010463)	pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)	3	142898802	187898802	Rat
8662816	Vetf4	Vascular elastic tissue fragility QTL 4	4		renal artery integrity trait (VT:0010642)	number of ruptures of the internal elastic lamina of the renal arteries (CMO:0002563)	3	79649560	177741895	Rat
1559282	Emca5	Estrogen-induced mammary cancer QTL 5	3.9		mammary gland integrity trait (VT:0010552)	percentage of study population developing mammary tumors during a period of time (CMO:0000948)	3	145335553	189428310	Rat
1582256	Insul9	Insulin level QTL 9	4.4	0.0016	blood insulin amount (VT:0001560)	absolute change in serum insulin level (CMO:0002038)	3	155759447	189428310	Rat
1576306	Schws3	Schwannoma susceptibility QTL 3		0.001	nervous system integrity trait (VT:0010566)	percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)	3	139299381	184299381	Rat
1300159	Kidm4	Kidney mass QTL 4	3.83		kidney mass (VT:0002707)	right kidney wet weight to body weight ratio (CMO:0001953)	3	141508991	177728348	Rat
2301971	Cm71	Cardiac mass QTL 71	4.63		heart left ventricle mass (VT:0007031)	heart left ventricle weight (CMO:0000776)	3	131036586	176036586	Rat
631673	Iddm13	Insulin dependent diabetes mellitus QTL 13	1.3	0.663	blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	3	137114333	182114333	Rat
1582248	Insul7	Insulin level QTL 7	3.9	0.0041	blood insulin amount (VT:0001560)	calculated serum insulin level (CMO:0000359)	3	155759447	189428310	Rat
2301970	Bw81	Body weight QTL 81	5.19		body mass (VT:0001259)	body weight (CMO:0000012)	3	131036586	176036586	Rat
1578666	Vnigr1	Vascular neointimal growth QTL 1	4.6		artery morphology trait (VT:0002191)	artery lumen area (CMO:0001409)	3	151075912	189428310	Rat
1578656	Vnigr2	Vascular neointimal growth QTL 2	4.2		artery morphology trait (VT:0002191)	lesioned artery residual lumen area (CMO:0001417)	3	151075912	189428310	Rat
12879871	Am7	Aortic mass QTL 7		0.001	aorta mass (VT:0002845)	aorta weight to aorta length to body weight ratio (CMO:0002722)	3	141555229	186555229	Rat
631541	Bp81	Blood pressure QTL 81	4		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	3	144575244	189428310	Rat

Markers in Region

RH140959

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	3	151,669,089 - 151,669,271 (+)	MAPPER	mRatBN7.2
Rnor_6.0	3	159,385,453 - 159,385,634	NCBI	Rnor6.0
Rnor_5.0	3	165,581,526 - 165,581,707	UniSTS	Rnor5.0
RGSC_v3.4	3	153,889,721 - 153,889,902	UniSTS	RGSC3.4
Celera	3	150,326,431 - 150,326,612	UniSTS
RH 3.4 Map	3	1388.3	UniSTS
Cytogenetic Map	3	q42	UniSTS

AA891709

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	3	151,654,302 - 151,654,514 (+)	MAPPER	mRatBN7.2
Rnor_6.0	3	159,371,555 - 159,371,766	NCBI	Rnor6.0
Rnor_5.0	3	165,567,628 - 165,567,839	UniSTS	Rnor5.0
RGSC_v3.4	3	153,874,936 - 153,875,147	UniSTS	RGSC3.4
Celera	3	150,311,646 - 150,311,857	UniSTS
RH 3.4 Map	3	1389.0	UniSTS
Cytogenetic Map	3	q42	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
16	6	10	94	90	90	59	36	59	6	227	67	2	75	81	74	31	12	12

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_134463	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AF361756	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH474005	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000003	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000041688 ⟹ ENSRNOP00000040718

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	3	172,071,081 - 172,089,011 (+)	Ensembl
mRatBN7.2 Ensembl	3	151,651,515 - 151,669,480 (+)	Ensembl
Rnor_6.0 Ensembl	3	159,368,273 - 159,384,775 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000095429 ⟹ ENSRNOP00000090611

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	3	172,063,776 - 172,089,011 (+)	Ensembl
mRatBN7.2 Ensembl	3	151,644,102 - 151,669,480 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000108319 ⟹ ENSRNOP00000081213

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	3	172,063,776 - 172,089,011 (+)	Ensembl
mRatBN7.2 Ensembl	3	151,644,102 - 151,669,480 (+)	Ensembl

RefSeq Acc Id:

NM_134463 ⟹ NP_604458

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	3	172,063,625 - 172,089,000 (+)	NCBI
mRatBN7.2	3	151,644,102 - 151,669,480 (+)	NCBI
Rnor_6.0	3	159,361,313 - 159,385,843 (+)	NCBI
Rnor_5.0	3	165,557,662 - 165,581,916 (+)	NCBI
RGSC_v3.4	3	153,849,825 - 153,890,111 (+)	RGD
Celera	3	150,301,782 - 150,326,821 (+)	RGD

Sequence:

show sequence

CAGCTGTCCGGGAGCCAGTGGTACAGCAACCACGGTGATTCAGTCCAGCAGTTAATTAGTAACC
GGAAGGTCTCGAAGCTGGCTGTCAGCTGGCAGGGCTGGGAGGCTGGACCTGTGCTGGTTTGAGA
GTCAGGCGAGTGGGTGACAGGTCACTCCTGCTTAGGAAGGTTGTAGGGTGAGTCAGGATTGGGT
TTCAGGTCAGAAGGACGGTGCAAAGGGAGAGAACCTTTATTCTCCAGGACCTGCGCTGGAACCT
GGGGGTTTCCAGGGAGAAATGGTGACCCCGTGGGAACAGAGGTCTCCCATCCCATCCTAAGCTG
CTGGATCCTGCGTGACATCACCAGTCCCCTCGCTGCTGCCACTGTTGGAAGCTCTGAGCTCTGT
GCTGGGGGCACCAGGCACTGACACTTGGCTCTTGTTGAGAGAACAGTGAGAGTCTCTCTTGTCC
ACGGCCTGTGCTCCGCTCCAACTGCTGCATCTCCCAGAGGCTCTGCTCTGCCCAGGCTGCATAG
AGCCTATCAGATCATAGCTACAGAATGGCCTCCAGCCCAGTTGGAGTTCCTAGCCCCCAGCCCT
CTAGGGCCAATGGGAACATCAACCTGGGGCCATCAGCCAACCCAAATGCCCGACCCACAGACTT
TGATTTCCTCAAAGTCATTGGCAAAGGGAACTATGGGAAGGTCCTACTGGCCAAGCGCAAGTCA
GACGGAGCCTTCTATGCCGTGAAGGTGCTGCAGAAGAAGTCCATCTTAAAAAACAAAGAGCAGA
GCCACATCATGGCAGAACGCAACGTGCTACTGAAGAACGTGCGGCACCCCTTCCTTGTGGGCCT
GCGCTACTCCTTCCAGACCCCAGAGAAGCTCTACTTTGTGCTTGACTATGTCAACGGGGGAGAG
CTTTTCTTCCATCTCCAGCGGGAACACAGGTTCCTGGAGCCCCGGGCCCGGTTCTACACGGCAG
AGGTGGCAAGCGCCATCGGTTATCTTCACTCTCTCAACATCATCTACAGAGACCTGAAGCCAGA
AAACATTCTCTTGGACTGCCAGGGTCACGTGGTACTGACAGATTTCGGCCTTTGCAAGGAATGT
GTAGAGCCCGAGGAGACCACATCCACCTTCTGCGGCACCCCTGAGTACTTGGCTCCAGAAGTCC
TTCGTAAAGAGCCTTACGATCGAGCAGTCGACTGGTGGTGCTTAGGGGCCGTTCTCTACGAGAT
GCTGCACGGCCTGCCCCCCTTCTTCAACACAGATGTGGCCCAGATGTATGAGAACATTTTGCAT
CAGCCGCTACAGATCCCTGGAGGCCGGACAGTGGCTGCCTGTGACCTCCTGCAGGGTCTTCTCC
ACAAGGACCAGAGGCAGCGGCTGGGCTCCAAGGAAGACTTTCTCGACATAAAGAACCACATGTT
CTTCAGTCCCATAAATTGGGATGATCTGTACCACAAGAGGCTGACTCCACCCTTCAACCCAAAC
GTGGAGGGACCCGCTGACTTGAAACACTTTGACCCAGAGTTCACCCAGGAGGCTGTGTCCAAGT
CCATTGGCTGCACCCCTGACACCATGTCCAGCAGTTCTGGGGCCTCAAGTGCATTCCTCGGATT
CTCCTATGCACAGGATGATGATGACATCTTGGACTCTTGAGAGCCAAGTGCTTGGAAAGCCACC
AAGCCCAGCTGGGACCTGCAGGAACTACCTTCTGCTGCACTAAGACACGACGAGTCCCGAAGAA
GTCAGATGCAGTAGCTCAGGGAAGAGGGGAGCATTTTCCATCCCATAAAAGAACGGTGAAGGGT
TCAGGCTGGCTGACTAGGCTCCCGAGTACCCAGCCGTCTGCGGTTGAGACTTGCCCTTCTTGAG
AAATGACTTCTGTGCTTGGTTTTTCATTTTTGGTTTTGTTTGTTGTTGCTGAGGCTGTGACAAA
GTATGCAAGAAAAGTAATGTAAAGAATATCTATTTGGGCTCACAGTTTCAGAAGGTTCAGCCCA
TAGTTGGCTGATCCATTGCTGTGGTCTTTAGCCGAAGTTGAGTCATCTTGCTGGAAGGAGTGAC
TTACCCTATGCCTAGCAGGAAACAGAAACTGAGTCTGGGTTGGGAATAAGATACCTTCTGATAA
GATATTTCTGAGTGACCCACTCCCTTCCAGTGGGGCCAATGTCCTAGTTATCACCTCTCCGTGC
TATAAAATTACAAATCTGTGAATGGACTAACTTGCTGAGGAAGCCTGAGCCCCTCCCTCATTGC
ATAGTGATCCAATCAGTTACGAAAGGCCTTATCAGCTGAACACCACAACCTTCAGAAAACACTT
CAGATCAGAAGCACGATGGCTTTGAATATTGGGTTACGAGACCACAAAGTGGCCTGCTGGTCAC
TTTTGTGTTCTAAGCAAGAGAAAAGGAGGAACGGGACAGAAGTGGGTTGCCCGGAAGCCCGGTC
TGGTGGCTTCCTTTAGTGTGTCATAAATTCTCCAGCTCTACTGGAATAGAGCCTGGGCACAAGC
TACCTCTCTTAGTAAGAGGGTTCGAATGCTGAGGGAGAGGGGAGAATGTGGCGGAGGCGACCGG
CACTCTGGGAGAGGACCTCTTGGTAGCTGGATTTTTATTTCTGTGTATAAATTGATGAAATGTA
GTGAGCCTGTCATGTGTTGCCTTCGGTTTCACATTGCTCTGTGGGTGGTGTCTTTGTTTGAGGT
GGCATTAAACACACTGGATA

hide sequence

Protein Sequences


Protein RefSeqs	NP_604458	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAL91351	(Get FASTA)	NCBI Sequence Viewer
	EDL96598	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000081213
	ENSRNOP00000081213.1
GenBank Protein	Q8R4U9	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

NP_604458 ⟸ NM_134463

- UniProtKB:

Q8R4U9 (UniProtKB/Swiss-Prot), A6JX11 (UniProtKB/TrEMBL), A0A8I6A9X9 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MASSPVGVPSPQPSRANGNINLGPSANPNARPTDFDFLKVIGKGNYGKVLLAKRKSDGAFYAVK
VLQKKSILKNKEQSHIMAERNVLLKNVRHPFLVGLRYSFQTPEKLYFVLDYVNGGELFFHLQRE
HRFLEPRARFYTAEVASAIGYLHSLNIIYRDLKPENILLDCQGHVVLTDFGLCKECVEPEETTS
TFCGTPEYLAPEVLRKEPYDRAVDWWCLGAVLYEMLHGLPPFFNTDVAQMYENILHQPLQIPGG
RTVAACDLLQGLLHKDQRQRLGSKEDFLDIKNHMFFSPINWDDLYHKRLTPPFNPNVEGPADLK
HFDPEFTQEAVSKSIGCTPDTMSSSSGASSAFLGFSYAQDDDDILDS

hide sequence

Ensembl Acc Id:

ENSRNOP00000040718 ⟸ ENSRNOT00000041688

Ensembl Acc Id:

ENSRNOP00000090611 ⟸ ENSRNOT00000095429

Ensembl Acc Id:

ENSRNOP00000081213 ⟸ ENSRNOT00000108319

Protein Domains

AGC-kinase C-terminal Protein kinase

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q8R4U9-F1-model_v2	AlphaFold	Q8R4U9	1-367	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:620232	AgrOrtholog
BioCyc Gene	G2FUF-46926	BioCyc
Ensembl Genes	ENSRNOG00000033573	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript	ENSRNOT00000108319	ENTREZGENE
	ENSRNOT00000108319.1	UniProtKB/Swiss-Prot
Gene3D-CATH	Phosphorylase Kinase, domain 1	UniProtKB/Swiss-Prot
	Transferase(Phosphotransferase) domain 1	UniProtKB/Swiss-Prot
InterPro	AGC-kinase_C	UniProtKB/Swiss-Prot
	Kinase-like_dom_sf	UniProtKB/Swiss-Prot
	Pkinase_C	UniProtKB/Swiss-Prot
	Prot_kinase_dom	UniProtKB/Swiss-Prot
	Protein_kinase_ATP_BS	UniProtKB/Swiss-Prot
	Ser/Thr_kinase_AS	UniProtKB/Swiss-Prot
KEGG Report	rno:171497	UniProtKB/Swiss-Prot
NCBI Gene	171497	ENTREZGENE
PANTHER	RIBOSOMAL PROTEIN S6 KINASE	UniProtKB/Swiss-Prot
Pfam	Pkinase	UniProtKB/Swiss-Prot
	Pkinase_C	UniProtKB/Swiss-Prot
PhenoGen	Sgk2	PhenoGen
PROSITE	AGC_KINASE_CTER	UniProtKB/Swiss-Prot
	PROTEIN_KINASE_ATP	UniProtKB/Swiss-Prot
	PROTEIN_KINASE_DOM	UniProtKB/Swiss-Prot
	PROTEIN_KINASE_ST	UniProtKB/Swiss-Prot
RatGTEx	ENSRNOG00000033573	RatGTEx
SMART	S_TK_X	UniProtKB/Swiss-Prot
	S_TKc	UniProtKB/Swiss-Prot
Superfamily-SCOP	SSF56112	UniProtKB/Swiss-Prot
UniProt	A0A8I6A9X9	ENTREZGENE, UniProtKB/TrEMBL
	A6JX11	ENTREZGENE, UniProtKB/TrEMBL
	Q8R4U9	ENTREZGENE
	R9PXX7_RAT	UniProtKB/TrEMBL
	SGK2_RAT	UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2019-04-02	Sgk2	serum/glucocorticoid regulated kinase 2	Sgk2	SGK2, serine/threonine kinase 2	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2017-05-12	Sgk2	SGK2, serine/threonine kinase 2	Sgk2	serum/glucocorticoid regulated kinase 2	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2004-09-10	Sgk2	serum/glucocorticoid regulated kinase 2			Symbol and Name status set to approved	1299863	APPROVED
2002-08-07	Sgk2	serum/glucocorticoid regulated kinase 2			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD