Mmp16 (matrix metallopeptidase 16) - Rat Genome Database

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Gene: Mmp16 (matrix metallopeptidase 16) Rattus norvegicus
Analyze
Symbol: Mmp16
Name: matrix metallopeptidase 16
RGD ID: 620199
Description: Predicted to enable metalloaminopeptidase activity; metalloendopeptidase activity; and zinc ion binding activity. Involved in response to odorant. Predicted to be located in extracellular matrix. Predicted to be active in extracellular space and plasma membrane. Orthologous to human MMP16 (matrix metallopeptidase 16); INTERACTS WITH 17alpha-ethynylestradiol; 17beta-estradiol 3-benzoate; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: matrix metalloproteinase 16; matrix metalloproteinase-16; membrane-type matrix metalloproteinase 3; membrane-type-3 matrix metalloproteinase; MMP-16; MT-MMP 3; Mt3-mmp; MT3MMP; MTMMP3
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Candidate Gene For: Vetf3
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8536,109,265 - 36,353,252 (+)NCBIGRCr8
mRatBN7.2531,312,280 - 31,556,276 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl531,312,280 - 31,548,388 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx533,458,804 - 33,703,762 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0535,051,511 - 35,296,458 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0534,991,048 - 35,235,995 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0531,568,344 - 31,818,368 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl531,568,419 - 31,810,484 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0536,239,463 - 36,484,341 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4532,352,311 - 32,586,469 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1532,352,489 - 32,586,648 (+)NCBI
Celera530,477,009 - 30,710,815 (+)NCBICelera
Cytogenetic Map5q13NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (ISO)
17beta-estradiol 3-benzoate  (EXP)
17beta-hydroxy-17-methylestra-4,9,11-trien-3-one  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2-palmitoylglycerol  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-sulfonyldiphenol  (EXP)
5-aza-2'-deoxycytidine  (ISO)
6-propyl-2-thiouracil  (EXP)
8-Br-cAMP  (ISO)
acetamide  (EXP)
acrylamide  (ISO)
afimoxifene  (ISO)
aflatoxin B1  (ISO)
amitriptyline  (EXP)
ammonium chloride  (EXP)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
benzo[a]pyrene  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP)
Butylbenzyl phthalate  (ISO)
calcitriol  (ISO)
cefaloridine  (EXP)
chromium(6+)  (ISO)
cisplatin  (ISO)
cobalt dichloride  (ISO)
colforsin daropate hydrochloride  (ISO)
coumestrol  (ISO)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
dibutyl phthalate  (ISO)
diclofenac  (ISO)
diethyl phthalate  (ISO)
diisobutyl phthalate  (ISO)
diisononyl phthalate  (ISO)
diuron  (EXP)
dorsomorphin  (ISO)
elemental selenium  (ISO)
entinostat  (ISO)
ethanol  (ISO)
geldanamycin  (ISO)
genistein  (ISO)
gentamycin  (EXP)
mercury dibromide  (ISO)
methotrexate  (ISO)
methylmercury chloride  (ISO)
microcystin-LR  (ISO)
mifepristone  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
nickel sulfate  (ISO)
ozone  (ISO)
paclitaxel  (ISO)
paracetamol  (EXP,ISO)
phenylmercury acetate  (ISO)
pirinixic acid  (EXP)
potassium chromate  (ISO)
progesterone  (ISO)
resveratrol  (ISO)
SB 431542  (ISO)
selenium atom  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium fluoride  (ISO)
testosterone  (ISO)
tetrachloromethane  (EXP)
thimerosal  (ISO)
titanium dioxide  (ISO)
trichostatin A  (ISO)
triptonide  (ISO)
valproic acid  (EXP,ISO)
vinclozolin  (EXP)
vorinostat  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Novel odors affect gene expression for cytokines and proteinases in the rat amygdala and hippocampus. Irwin LN and Byers DM, Brain Res. 2012 Dec 13;1489:1-7. doi: 10.1016/j.brainres.2012.10.034. Epub 2012 Oct 26.
3. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
4. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
5. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
6. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
7. Expression of three membrane-type matrix metalloproteinases (MT-MMPs) in rat vascular smooth muscle cells and characterization of MT3-MMPs with and without transmembrane domain. Shofuda K, etal., J Biol Chem 1997 Apr 11;272(15):9749-54.
Additional References at PubMed
PMID:7559440   PMID:18022611   PMID:18784838   PMID:24970228   PMID:27229514  


Genomics

Comparative Map Data
Mmp16
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8536,109,265 - 36,353,252 (+)NCBIGRCr8
mRatBN7.2531,312,280 - 31,556,276 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl531,312,280 - 31,548,388 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx533,458,804 - 33,703,762 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0535,051,511 - 35,296,458 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0534,991,048 - 35,235,995 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0531,568,344 - 31,818,368 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl531,568,419 - 31,810,484 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0536,239,463 - 36,484,341 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4532,352,311 - 32,586,469 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1532,352,489 - 32,586,648 (+)NCBI
Celera530,477,009 - 30,710,815 (+)NCBICelera
Cytogenetic Map5q13NCBI
MMP16
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38888,032,011 - 88,327,483 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl888,032,011 - 88,328,025 (-)EnsemblGRCh38hg38GRCh38
GRCh37889,044,239 - 89,339,712 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36889,118,576 - 89,408,833 (-)NCBINCBI36Build 36hg18NCBI36
Build 34889,150,576 - 89,408,664NCBI
Celera885,244,102 - 85,534,339 (-)NCBICelera
Cytogenetic Map8q21.3NCBI
HuRef884,259,378 - 84,549,728 (-)NCBIHuRef
CHM1_1889,091,126 - 89,381,311 (-)NCBICHM1_1
T2T-CHM13v2.0889,155,362 - 89,450,838 (-)NCBIT2T-CHM13v2.0
Mmp16
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39417,853,072 - 18,117,479 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl417,852,893 - 18,119,145 (+)EnsemblGRCm39 Ensembl
GRCm38417,853,072 - 18,117,479 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl417,852,893 - 18,119,145 (+)EnsemblGRCm38mm10GRCm38
MGSCv37417,780,629 - 18,045,881 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36417,780,629 - 18,043,779 (+)NCBIMGSCv36mm8
Celera417,643,862 - 17,905,148 (+)NCBICelera
Cytogenetic Map4A3NCBI
cM Map47.08NCBI
Mmp16
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554175,303,290 - 5,545,589 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554175,298,334 - 5,545,121 (-)NCBIChiLan1.0ChiLan1.0
MMP16
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v27105,448,631 - 105,738,792 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1880,982,570 - 81,272,589 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0884,736,752 - 85,026,711 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1886,693,022 - 86,983,028 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl886,701,882 - 86,982,518 (-)Ensemblpanpan1.1panPan2
MMP16
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12933,896,133 - 34,207,560 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2933,917,907 - 34,207,466 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2934,056,176 - 34,360,687 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02934,093,268 - 34,403,773 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2934,120,818 - 34,403,822 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12934,106,198 - 34,398,221 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02934,114,566 - 34,418,869 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02934,536,488 - 34,840,936 (-)NCBIUU_Cfam_GSD_1.0
Mmp16
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440530345,246,022 - 45,504,496 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365442,298,028 - 2,546,689 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365442,297,698 - 2,546,683 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MMP16
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl448,556,967 - 48,862,985 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1448,556,826 - 48,867,959 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2453,295,213 - 53,606,489 (+)NCBISscrofa10.2Sscrofa10.2susScr3
MMP16
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1883,122,904 - 83,407,910 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl883,132,315 - 83,407,933 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603957,498,698 - 57,789,347 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Mmp16
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247443,544,552 - 3,796,821 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247443,544,258 - 3,806,097 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Mmp16
1471 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:583
Count of miRNA genes:265
Interacting mature miRNAs:342
Transcripts:ENSRNOT00000050137
Prediction methods:Microtar, Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1331756Rf34Renal function QTL 344.16275kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)5190450412Rat
70212Niddm25Non-insulin dependent diabetes mellitus QTL 253.54blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)51131345958Rat
1331771Rf35Renal function QTL 354.36965kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)572947086724018Rat
2312562Pur18Proteinuria QTL 182.60.001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)5213896532656739Rat
1576314Eutr1Estrogen induced uterine response QTL 1uterus integrity trait (VT:0010575)pyometritis severity score (CMO:0002009)52138965166875058Rat
8662454Vetf3Vascular elastic tissue fragility QTL 327.4artery integrity trait (VT:0010639)number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)5228222669540447Rat
1300117Hrtrt8Heart rate QTL 83.49heart pumping trait (VT:2000009)heart rate (CMO:0000002)5384401847869213Rat
61462Niddm10Non-insulin dependent diabetes mellitus QTL 103.90.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)5511215947171491Rat
2293666Bmd38Bone mineral density QTL 384.4femur size trait (VT:1000369)femoral neck cortical cross-sectional area (CMO:0001702)5894822853948228Rat
7394712Emca13Estrogen-induced mammary cancer QTL 13mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)5982326699753708Rat
1641903Alcrsp3Alcohol response QTL 3response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)51268928557689285Rat
634305Mamtr1Mammary tumor resistance QTL 10.0001mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)512789751113558310Rat
1600358Mamtr5Mammary tumor resistance QTL 5mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)51887394763873947Rat
1358353Srcrtb2Stress Responsive Cort Basal QTL 23.480.003blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)51887394774251464Rat
8552954Pigfal14Plasma insulin-like growth factor 1 level QTL 149blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)52122674466226744Rat
1549901Neudeg2Neurodegradation QTL 240nervous system integrity trait (VT:0010566)mononuclear cell count (CMO:0002119)52483871044045280Rat
1578767Stresp17Stress response QTL 174.30.01blood aldosterone amount (VT:0005346)plasma aldosterone level (CMO:0000551)52795544072955440Rat
1578776Stresp18Stress response QTL 182.9thymus mass (VT:0004954)thymus wet weight (CMO:0000855)52795544072955440Rat
6903292Stl28Serum triglyceride level QTL 282.60.0073blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)52851548973515489Rat
6903306Scl35Serum cholesterol QTL 352.60.0073blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)52851548973515489Rat

Markers in Region
D5Wox36  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2531,547,367 - 31,547,578 (+)MAPPERmRatBN7.2
Rnor_6.0531,809,466 - 31,809,674NCBIRnor6.0
Rnor_5.0536,478,685 - 36,478,893UniSTSRnor5.0
RGSC_v3.4532,585,451 - 32,585,659UniSTSRGSC3.4
Celera530,709,797 - 30,710,005UniSTS
Cytogenetic Map5q13UniSTS
AW532313  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2531,360,600 - 31,360,759 (+)MAPPERmRatBN7.2
Rnor_6.0531,616,409 - 31,616,567NCBIRnor6.0
Rnor_5.0536,287,477 - 36,287,635UniSTSRnor5.0
RGSC_v3.4532,400,967 - 32,401,125UniSTSRGSC3.4
Celera530,525,242 - 30,525,400UniSTS
RH 3.4 Map5162.72UniSTS
Cytogenetic Map5q13UniSTS
AB021228  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2531,547,101 - 31,547,244 (+)MAPPERmRatBN7.2
Rnor_6.0531,809,200 - 31,809,342NCBIRnor6.0
Rnor_5.0536,478,419 - 36,478,561UniSTSRnor5.0
RGSC_v3.4532,585,185 - 32,585,327UniSTSRGSC3.4
Celera530,709,531 - 30,709,673UniSTS
Cytogenetic Map5q13UniSTS
BE115606  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2531,548,182 - 31,548,350 (+)MAPPERmRatBN7.2
Rnor_6.0531,810,279 - 31,810,446NCBIRnor6.0
Rnor_5.0536,479,498 - 36,479,665UniSTSRnor5.0
RGSC_v3.4532,586,264 - 32,586,431UniSTSRGSC3.4
Celera530,710,610 - 30,710,777UniSTS
RH 3.4 Map5162.82UniSTS
Cytogenetic Map5q13UniSTS
MMP16_920  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2531,546,930 - 31,547,841 (+)MAPPERmRatBN7.2
Rnor_6.0531,809,029 - 31,809,937NCBIRnor6.0
Rnor_5.0536,478,248 - 36,479,156UniSTSRnor5.0
RGSC_v3.4532,585,014 - 32,585,922UniSTSRGSC3.4
Celera530,709,360 - 30,710,268UniSTS
Cytogenetic Map5q13UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 2 2 2 72 12 28 9
Low 3 37 54 39 18 39 7 7 2 12 13 2 7
Below cutoff 6 1 1 1 4 11 1

Sequence


RefSeq Acc Id: ENSRNOT00000050137   ⟹   ENSRNOP00000040229
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl531,312,280 - 31,548,388 (+)Ensembl
Rnor_6.0 Ensembl531,568,419 - 31,810,484 (+)Ensembl
RefSeq Acc Id: NM_080776   ⟹   NP_542954
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8536,109,265 - 36,353,252 (+)NCBI
mRatBN7.2531,312,280 - 31,556,276 (+)NCBI
Rnor_6.0531,568,419 - 31,810,484 (+)NCBI
Rnor_5.0536,239,463 - 36,484,341 (+)NCBI
RGSC_v3.4532,352,311 - 32,586,469 (+)RGD
Celera530,477,009 - 30,710,815 (+)RGD
Sequence:
RefSeq Acc Id: XM_039110732   ⟹   XP_038966660
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8536,265,806 - 36,345,365 (+)NCBI
mRatBN7.2531,468,802 - 31,556,274 (+)NCBI
Protein Sequences
Protein RefSeqs NP_542954 (Get FASTA)   NCBI Sequence Viewer  
  XP_038966660 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein BAA22223 (Get FASTA)   NCBI Sequence Viewer  
  EDL98489 (Get FASTA)   NCBI Sequence Viewer  
  EDL98490 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000040229
  ENSRNOP00000040229.6
GenBank Protein O35548 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_542954   ⟸   NM_080776
- Peptide Label: precursor
- UniProtKB: O35548 (UniProtKB/Swiss-Prot),   O35541 (UniProtKB/Swiss-Prot),   F1M7F5 (UniProtKB/TrEMBL),   A6IIB9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000040229   ⟸   ENSRNOT00000050137
RefSeq Acc Id: XP_038966660   ⟸   XM_039110732
- Peptide Label: isoform X1
Protein Domains
Peptidase metallopeptidase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-O35548-F1-model_v2 AlphaFold O35548 1-607 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13693583
Promoter ID:EPDNEW_R4108
Type:initiation region
Name:Mmp16_1
Description:matrix metallopeptidase 16
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0531,568,431 - 31,568,491EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620199 AgrOrtholog
BioCyc Gene G2FUF-41847 BioCyc
Ensembl Genes ENSRNOG00000005708 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000050137 ENTREZGENE
  ENSRNOT00000050137.6 UniProtKB/TrEMBL
Gene3D-CATH 2.110.10.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.40.390.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Hemopexin-like_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Hemopexin-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Hemopexin-like_repeat UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Hemopexin_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  M10A_MMP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MetalloPept_cat_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pept_M10_metallopeptidase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pept_M10A UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pept_M10A_metallopeptidase_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pept_M10A_Zn_BS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_Metallo UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidoglycan-bd-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PGBD-like_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:65205 UniProtKB/Swiss-Prot
NCBI Gene 65205 ENTREZGENE
PANTHER MATRIX METALLOPROTEINASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR10201:SF26 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam DUF3377 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Hemopexin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_M10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PG_binding_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Mmp16 PhenoGen
PIRSF Peptidase_M10A_matrix UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS MATRIXIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE CYSTEINE_SWITCH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HEMOPEXIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HEMOPEXIN_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ZINC_PROTEASE UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000005708 RatGTEx
SMART SM00120 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ZnMc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP Metalloproteases ('zincins'), catalytic domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF47090 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF50923 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A6IIB9 ENTREZGENE, UniProtKB/TrEMBL
  F1M7F5 ENTREZGENE, UniProtKB/TrEMBL
  MMP16_RAT UniProtKB/Swiss-Prot
  O35541 ENTREZGENE
  O35548 ENTREZGENE
UniProt Secondary O35541 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-02-22 Mmp16  matrix metallopeptidase 16  Mmp16  matrix metalloproteinase 16  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-02-26 Mmp16  matrix metalloproteinase 16      Symbol and Name status set to approved 625702 APPROVED
2002-08-07 Mmp16        Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_function cleaves endogenous progelatinase A to its mature form 729074
gene_protein 607 amino acids 729074