Dync1i2 (dynein cytoplasmic 1 intermediate chain 2) - Rat Genome Database

Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Pathways
Gene: Dync1i2 (dynein cytoplasmic 1 intermediate chain 2) Rattus norvegicus
Analyze
Symbol: Dync1i2
Name: dynein cytoplasmic 1 intermediate chain 2
RGD ID: 620174
Description: Predicted to enable dynein heavy chain binding activity and dynein light chain binding activity. Involved in cellular response to nerve growth factor stimulus and negative regulation of neuron projection development. Predicted to be located in centrosome; microtubule; and vesicle. Predicted to be part of cytoplasmic dynein complex and outer dynein arm. Orthologous to human DYNC1I2 (dynein cytoplasmic 1 intermediate chain 2); PARTICIPATES IN mitochondria transport pathway; phagocytosis pathway; vasopressin signaling pathway via receptor type 2; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dibromophenyl 2,4,5-tribromophenyl ether; 2,6-dinitrotoluene.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: cytoplasmic dynein 1 intermediate chain 2; cytoplasmic dynein intermediate chain 2; DH IC-2; Dnci2; Dncic2; dynein intermediate chain 2, cytosolic; dynein, cytoplasmic, intermediate chain 2; dynein, cytoplasmic, intermediate polypeptide 2; MGC93277; oncofetal protein (OFP)
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8376,441,621 - 76,492,782 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl376,424,469 - 76,492,782 (+)EnsemblGRCr8
mRatBN7.2356,033,882 - 56,085,080 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl356,033,917 - 56,085,080 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx359,431,604 - 59,482,847 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0368,015,213 - 68,066,454 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0365,777,439 - 65,828,519 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0357,817,677 - 57,868,854 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl357,817,693 - 57,868,854 (+)Ensemblrn6Rnor6.0
Rnor_5.0364,314,254 - 64,364,653 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4353,480,918 - 53,533,222 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera355,581,617 - 55,633,089 (+)NCBICelera
RGSC_v3.1353,377,289 - 53,429,594 (+)NCBI
Cytogenetic Map3q22NCBI
JBrowse:




Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Cytoplasmic dynein. Allan VJ, Biochem Soc Trans. 2011 Oct;39(5):1169-78. doi: 10.1042/BST0391169.
2. Live cell imaging reveals differential modifications to cytoplasmic dynein properties by phospho- and dephosphomimic mutations of the intermediate chain 2C S84. Blasier KR, etal., J Neurosci Res. 2014 Sep;92(9):1143-54. doi: 10.1002/jnr.23388. Epub 2014 May 5.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
5. Integrated proteomics identified novel activation of dynein IC2-GR-COX-1 signaling in neurofibromatosis type I (NF1) disease model cells. Hirayama M, etal., Mol Cell Proteomics. 2013 May;12(5):1377-94. doi: 10.1074/mcp.M112.024802. Epub 2013 Jan 28.
6. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
7. Identification and developmental regulation of a neuron-specific subunit of cytoplasmic dynein. Pfister KK, etal., Mol Biol Cell. 1996 Feb;7(2):331-43.
8. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
9. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
10. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
11. Growth factor regulation of cytoplasmic dynein intermediate chain subunit expression preceding neurite extension. Salata MW, etal., J Neurosci Res. 2001 Sep 1;65(5):408-16.
12. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
13. Cytoplasmic dynein binds dynactin through a direct interaction between the intermediate chains and p150Glued. Vaughan KT and Vallee RB, J Cell Biol 1995 Dec;131(6 Pt 1):1507-16.
Additional References at PubMed
PMID:20682791   PMID:21399614   PMID:21525035   PMID:23836931   PMID:25002582   PMID:27353389  


Genomics

Comparative Map Data
Dync1i2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8376,441,621 - 76,492,782 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl376,424,469 - 76,492,782 (+)EnsemblGRCr8
mRatBN7.2356,033,882 - 56,085,080 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl356,033,917 - 56,085,080 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx359,431,604 - 59,482,847 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0368,015,213 - 68,066,454 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0365,777,439 - 65,828,519 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0357,817,677 - 57,868,854 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl357,817,693 - 57,868,854 (+)Ensemblrn6Rnor6.0
Rnor_5.0364,314,254 - 64,364,653 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4353,480,918 - 53,533,222 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera355,581,617 - 55,633,089 (+)NCBICelera
RGSC_v3.1353,377,289 - 53,429,594 (+)NCBI
Cytogenetic Map3q22NCBI
DYNC1I2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382171,687,469 - 171,750,158 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2171,687,409 - 171,750,158 (+)Ensemblhg38GRCh38
GRCh372172,543,979 - 172,606,668 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362172,252,228 - 172,313,165 (+)NCBIBuild 36Build 36hg18NCBI36
Build 342172,369,488 - 172,430,426NCBI
Celera2166,160,554 - 166,221,488 (+)NCBICelera
Cytogenetic Map2q31.1NCBI
HuRef2164,429,292 - 164,492,025 (+)NCBIHuRef
CHM1_12172,550,676 - 172,613,534 (+)NCBICHM1_1
T2T-CHM13v2.02172,164,878 - 172,227,564 (+)NCBIT2T-CHM13v2.0
Dync1i2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39271,041,999 - 71,093,647 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl271,042,050 - 71,093,647 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38271,211,676 - 71,263,303 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl271,211,706 - 71,263,303 (+)Ensemblmm10GRCm38
MGSCv37271,050,070 - 71,101,351 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36271,012,852 - 71,064,133 (+)NCBIMGSCv36mm8
Celera272,870,734 - 72,922,164 (+)NCBICelera
Cytogenetic Map2C2NCBI
cM Map242.38NCBI
Dync1i2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554493,204,839 - 3,255,853 (-)Ensembl
ChiLan1.0NW_0049554493,204,839 - 3,256,059 (-)NCBIChiLan1.0ChiLan1.0
DYNC1I2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21374,364,029 - 74,424,938 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12B74,379,007 - 74,441,659 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02B58,977,379 - 59,039,514 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12B176,436,442 - 176,498,638 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B176,436,471 - 176,498,638 (+)EnsemblpanPan2panpan1.1
DYNC1I2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13616,103,480 - 16,163,232 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3616,103,751 - 16,162,215 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha3616,113,452 - 16,173,236 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.03616,224,349 - 16,284,203 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3616,224,362 - 16,284,112 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13616,311,937 - 16,372,018 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03616,311,893 - 16,371,695 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03616,414,689 - 16,474,496 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Dync1i2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405303133,361,095 - 133,415,960 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365091,914,893 - 1,973,943 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365091,915,006 - 1,969,857 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DYNC1I2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1577,803,350 - 77,860,041 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11577,803,601 - 77,859,559 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21587,190,717 - 87,246,863 (+)NCBISscrofa10.2Sscrofa10.2susScr3
DYNC1I2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11057,182,245 - 57,242,359 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1057,182,220 - 57,244,510 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_023666040142,304,754 - 142,365,418 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Dync1i2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247879,103,271 - 9,167,043 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247879,103,392 - 9,164,695 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Dync1i2
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1548,506,236 - 48,555,946 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Dync1i2
243 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:723
Count of miRNA genes:157
Interacting mature miRNAs:180
Transcripts:ENSRNOT00000013400, ENSRNOT00000047243, ENSRNOT00000067729
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300178Hrtrt4Heart rate QTL 43.74heart pumping trait (VT:2000009)heart rate (CMO:0000002)351490129111359995Rat
61377Edpm3Estrogen-dependent pituitary mass QTL 37.050.038pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)373592611110333156Rat
1358293Bw38Body weight QTL 3860.0000031body mass (VT:0001259)body weight (CMO:0000012)374364268119364268Rat
1582238Bw68Body weight QTL 683.20.0064body mass (VT:0001259)body weight (CMO:0000012)373592512136118980Rat
1331795Rf30Renal function QTL 303.708urine potassium amount (VT:0010539)urine potassium level (CMO:0000128)35986366387321459Rat
1582239Epfw1Epididymal fat weight QTL 14.50.0006epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)373592512136118980Rat
70216Cm14Cardiac mass QTL 142.1heart mass (VT:0007028)heart wet weight (CMO:0000069)351581665184004958Rat
1354589Bw31Body weight QTL 313.3body mass (VT:0001259)body weight (CMO:0000012)35365182698651826Rat
2303593Gluco46Glucose level QTL 463blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)34887661993876619Rat
1354590Despr11Despair related QTL 110.000031locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)34887661993876619Rat
2298542Neuinf11Neuroinflammation QTL 113.9nervous system integrity trait (VT:0010566)spinal cord complement component 1, q subcomponent, B chain mRNA level (CMO:0002126)33540319997383526Rat
2292591Esta4Estrogen-induced thymic atrophy QTL 4thymus mass (VT:0004954)thymus wet weight (CMO:0000855)367641776167835660Rat
1358362Srcrt2Stress Responsive Cort QTL 22.78blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)358601291153936591Rat
631832Sach1Saccharin preference QTL 12.70.02consumption behavior trait (VT:0002069)calculated saccharin drink intake volume (CMO:0001600)34790417292904172Rat
737818Hcar12Hepatocarcinoma resistance QTL 122.6liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)349872657138829559Rat
1582218Bw74Body weight QTL 743.90.0021body mass (VT:0001259)body weight (CMO:0000012)373592512136118980Rat
1331777Bw24Body weight QTL 243.503body mass (VT:0001259)body weight (CMO:0000012)35986366387321459Rat
631647Bp122Blood pressure QTL 1226.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)35109256196092561Rat
1300169Bp177Blood pressure QTL 1772.96arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)33642511681425116Rat
9590286Uminl1Urine mineral level QTL 13.50.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)34865774493657744Rat
724523Tsu1Thymus enlargement suppressive QTL 13.84thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)370845569136091483Rat
4889966Bss95Bone structure and strength QTL 954.4tibia area (VT:1000281)tibia-fibula cross-sectional area (CMO:0001718)33779691982796919Rat
2302276Bw82Body weight QTL 824.32body mass (VT:0001259)body weight (CMO:0000012)35986366383358329Rat
2292613Ept16Estrogen-induced pituitary tumorigenesis QTL 168.3pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)367641995130815812Rat
738019Anxrr10Anxiety related response QTL 103.9exploratory behavior trait (VT:0010471)number of entries into a discrete space in an experimental apparatus (CMO:0000960)358925062103925062Rat
631841Niddm39Non-insulin dependent diabetes mellitus QTL 393.36blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)370311536115311536Rat
9590136Scort3Serum corticosterone level QTL 323.370.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)34865774493657744Rat
61419Cia11Collagen induced arthritis QTL 115.6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)35076614595766145Rat
61356Bp37Blood pressure QTL 373blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)35109256196092561Rat
1358905Hrtrt17Heart rate QTL 175.90.000014heart pumping trait (VT:2000009)heart rate (CMO:0000002)336721849110333156Rat
1558650Cm48Cardiac mass QTL 4840.0001heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)35076614595766145Rat
8694196Abfw2Abdominal fat weight QTL 216.580.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)34865774493657744Rat
1358885Bp251Blood pressure QTL 2513.8arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)31141509147Rat
1354597Kidm13Kidney mass QTL 132.9kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)342158111124558371Rat
1582249Bw77Body weight QTL 773.20.0025epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)37359251285062403Rat
2325840Bp345Blood pressure QTL 3450.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)33870893183708931Rat
8552950Pigfal12Plasma insulin-like growth factor 1 level QTL 127.3blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)34865774493657744Rat
631676Cm8Cardiac mass QTL 87.030.0001aorta mass (VT:0002845)aorta weight (CMO:0000076)33736373482363734Rat
2290452Scl56Serum cholesterol level QTL 562.26blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)33610140381101403Rat
8694386Bw159Body weight QTL 1594.520.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)34865774493657744Rat
1354604Bw36Body weight QTL 362.9body mass (VT:0001259)body weight (CMO:0000012)342158111124558371Rat
1358888Bp264Blood pressure QTL 2644.43arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)35675975141509147Rat
1358186Ept2Estrogen-induced pituitary tumorigenesis QTL 28.3pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)367641995130815812Rat

Markers in Region
RH134802  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2356,084,688 - 56,084,897 (+)MAPPERmRatBN7.2
Rnor_6.0357,868,463 - 57,868,671NCBIRnor6.0
Rnor_5.0364,364,262 - 64,364,470UniSTSRnor5.0
RGSC_v3.4353,532,841 - 53,533,049UniSTSRGSC3.4
Celera355,632,698 - 55,632,906UniSTS
Cytogenetic Map3q21UniSTS
RH135346  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2356,084,461 - 56,084,675 (+)MAPPERmRatBN7.2
Rnor_6.0357,868,236 - 57,868,449NCBIRnor6.0
Rnor_5.0364,364,035 - 64,364,248UniSTSRnor5.0
RGSC_v3.4353,532,614 - 53,532,827UniSTSRGSC3.4
Celera355,632,471 - 55,632,684UniSTS
Cytogenetic Map3q21UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001270624 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001270625 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001429705 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001429706 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001429707 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001429708 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001429709 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001429710 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001429711 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_053880 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006234344 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006234346 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017591432 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039104115 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063283000 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063283001 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063283002 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063283003 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063283004 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063283005 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063283006 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063283007 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC107446 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC078764 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CB733957 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473949 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FM076575 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FM110655 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000003 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U39044 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U39045 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U39046 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X56145 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000013400   ⟹   ENSRNOP00000013400
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl376,441,842 - 76,492,774 (+)Ensembl
mRatBN7.2 Ensembl356,033,926 - 56,085,058 (+)Ensembl
Rnor_6.0 Ensembl357,817,693 - 57,868,854 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000047243   ⟹   ENSRNOP00000042414
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl376,441,621 - 76,492,782 (+)Ensembl
mRatBN7.2 Ensembl356,033,917 - 56,085,080 (+)Ensembl
Rnor_6.0 Ensembl357,817,693 - 57,868,854 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000067729   ⟹   ENSRNOP00000060919
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl376,441,621 - 76,492,782 (+)Ensembl
mRatBN7.2 Ensembl356,033,917 - 56,085,080 (+)Ensembl
Rnor_6.0 Ensembl357,817,693 - 57,868,854 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000144709   ⟹   ENSRNOP00000110714
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl376,424,469 - 76,492,782 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000154744   ⟹   ENSRNOP00000101529
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl376,441,621 - 76,492,782 (+)Ensembl
RefSeq Acc Id: NM_001270624   ⟹   NP_001257553
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8376,441,621 - 76,492,782 (+)NCBI
mRatBN7.2356,033,917 - 56,085,080 (+)NCBI
Rnor_6.0357,817,693 - 57,868,854 (+)NCBI
Rnor_5.0364,314,254 - 64,364,653 (+)NCBI
Celera355,581,617 - 55,633,089 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001270625   ⟹   NP_001257554
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8376,441,621 - 76,492,782 (+)NCBI
mRatBN7.2356,033,917 - 56,085,080 (+)NCBI
Rnor_6.0357,817,693 - 57,868,854 (+)NCBI
Rnor_5.0364,314,254 - 64,364,653 (+)NCBI
Celera355,581,617 - 55,633,089 (+)NCBI
Sequence:
RefSeq Acc Id: NM_053880   ⟹   NP_446332
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8376,441,621 - 76,492,782 (+)NCBI
mRatBN7.2356,033,917 - 56,085,080 (+)NCBI
Rnor_6.0357,817,693 - 57,868,854 (+)NCBI
Rnor_5.0364,314,254 - 64,364,653 (+)NCBI
RGSC_v3.4353,480,918 - 53,533,222 (+)RGD
Celera355,581,617 - 55,633,089 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006234344   ⟹   XP_006234406
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8376,441,653 - 76,492,769 (+)NCBI
mRatBN7.2356,033,882 - 56,084,766 (+)NCBI
Rnor_6.0357,817,678 - 57,868,671 (+)NCBI
Rnor_5.0364,314,254 - 64,364,653 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006234346   ⟹   XP_006234408
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8376,441,651 - 76,492,769 (+)NCBI
mRatBN7.2356,033,883 - 56,084,766 (+)NCBI
Rnor_6.0357,817,679 - 57,868,671 (+)NCBI
Rnor_5.0364,314,254 - 64,364,653 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017591432   ⟹   XP_017446921
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8376,441,720 - 76,492,769 (+)NCBI
mRatBN7.2356,033,918 - 56,084,766 (+)NCBI
Rnor_6.0357,817,677 - 57,868,671 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039104115   ⟹   XP_038960043
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8376,441,653 - 76,492,769 (+)NCBI
mRatBN7.2356,033,882 - 56,084,766 (+)NCBI
RefSeq Acc Id: XM_063283000   ⟹   XP_063139070
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8376,441,698 - 76,492,769 (+)NCBI
RefSeq Acc Id: XM_063283001   ⟹   XP_063139071
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8376,441,720 - 76,492,769 (+)NCBI
RefSeq Acc Id: XM_063283002   ⟹   XP_063139072
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8376,441,720 - 76,492,769 (+)NCBI
RefSeq Acc Id: XM_063283003   ⟹   XP_063139073
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8376,441,720 - 76,492,769 (+)NCBI
RefSeq Acc Id: XM_063283004   ⟹   XP_063139074
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8376,441,720 - 76,492,769 (+)NCBI
RefSeq Acc Id: XM_063283005   ⟹   XP_063139075
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8376,441,720 - 76,492,769 (+)NCBI
RefSeq Acc Id: XM_063283006   ⟹   XP_063139076
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8376,441,653 - 76,492,769 (+)NCBI
RefSeq Acc Id: XM_063283007   ⟹   XP_063139077
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8376,441,653 - 76,492,769 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001257553 (Get FASTA)   NCBI Sequence Viewer  
  NP_001257554 (Get FASTA)   NCBI Sequence Viewer  
  NP_001416634 (Get FASTA)   NCBI Sequence Viewer  
  NP_001416635 (Get FASTA)   NCBI Sequence Viewer  
  NP_001416636 (Get FASTA)   NCBI Sequence Viewer  
  NP_001416637 (Get FASTA)   NCBI Sequence Viewer  
  NP_001416638 (Get FASTA)   NCBI Sequence Viewer  
  NP_001416639 (Get FASTA)   NCBI Sequence Viewer  
  NP_001416640 (Get FASTA)   NCBI Sequence Viewer  
  NP_446332 (Get FASTA)   NCBI Sequence Viewer  
  XP_006234406 (Get FASTA)   NCBI Sequence Viewer  
  XP_006234408 (Get FASTA)   NCBI Sequence Viewer  
  XP_017446921 (Get FASTA)   NCBI Sequence Viewer  
  XP_038960043 (Get FASTA)   NCBI Sequence Viewer  
  XP_063139070 (Get FASTA)   NCBI Sequence Viewer  
  XP_063139071 (Get FASTA)   NCBI Sequence Viewer  
  XP_063139072 (Get FASTA)   NCBI Sequence Viewer  
  XP_063139073 (Get FASTA)   NCBI Sequence Viewer  
  XP_063139074 (Get FASTA)   NCBI Sequence Viewer  
  XP_063139075 (Get FASTA)   NCBI Sequence Viewer  
  XP_063139076 (Get FASTA)   NCBI Sequence Viewer  
  XP_063139077 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA89163 (Get FASTA)   NCBI Sequence Viewer  
  AAA89164 (Get FASTA)   NCBI Sequence Viewer  
  AAA89165 (Get FASTA)   NCBI Sequence Viewer  
  AAH78764 (Get FASTA)   NCBI Sequence Viewer  
  CAA39610 (Get FASTA)   NCBI Sequence Viewer  
  EDL79094 (Get FASTA)   NCBI Sequence Viewer  
  EDL79095 (Get FASTA)   NCBI Sequence Viewer  
  EDL79096 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000042414
  ENSRNOP00000060919
  ENSRNOP00000101529
  ENSRNOP00000110714
GenBank Protein Q62871 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_446332   ⟸   NM_053880
- Peptide Label: isoform 1
- UniProtKB: Q62873 (UniProtKB/Swiss-Prot),   Q62872 (UniProtKB/Swiss-Prot),   Q62871 (UniProtKB/Swiss-Prot),   G3V9V3 (UniProtKB/TrEMBL),   A6HM43 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001257553   ⟸   NM_001270624
- Peptide Label: isoform 2
- UniProtKB: Q62873 (UniProtKB/Swiss-Prot),   Q62872 (UniProtKB/Swiss-Prot),   Q62871 (UniProtKB/Swiss-Prot),   Q6AZ35 (UniProtKB/TrEMBL),   A6HM44 (UniProtKB/TrEMBL),   F7FJ03 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001257554   ⟸   NM_001270625
- Peptide Label: isoform 3
- UniProtKB: Q62873 (UniProtKB/Swiss-Prot),   Q62872 (UniProtKB/Swiss-Prot),   Q62871 (UniProtKB/Swiss-Prot),   D3ZU74 (UniProtKB/TrEMBL),   A6HM45 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006234406   ⟸   XM_006234344
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_006234408   ⟸   XM_006234346
- Peptide Label: isoform X6
- Sequence:
RefSeq Acc Id: XP_017446921   ⟸   XM_017591432
- Peptide Label: isoform X1
- UniProtKB: Q62873 (UniProtKB/Swiss-Prot),   Q62872 (UniProtKB/Swiss-Prot),   Q62871 (UniProtKB/Swiss-Prot),   G3V9V3 (UniProtKB/TrEMBL),   A6HM43 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000060919   ⟸   ENSRNOT00000067729
Ensembl Acc Id: ENSRNOP00000013400   ⟸   ENSRNOT00000013400
Ensembl Acc Id: ENSRNOP00000042414   ⟸   ENSRNOT00000047243
RefSeq Acc Id: XP_038960043   ⟸   XM_039104115
- Peptide Label: isoform X1
RefSeq Acc Id: XP_063139076   ⟸   XM_063283006
- Peptide Label: isoform X4
RefSeq Acc Id: XP_063139077   ⟸   XM_063283007
- Peptide Label: isoform X7
RefSeq Acc Id: XP_063139070   ⟸   XM_063283000
- Peptide Label: isoform X2
- UniProtKB: Q62873 (UniProtKB/Swiss-Prot),   Q62872 (UniProtKB/Swiss-Prot),   Q62871 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_063139073   ⟸   XM_063283003
- Peptide Label: isoform X5
- UniProtKB: Q62873 (UniProtKB/Swiss-Prot),   Q62872 (UniProtKB/Swiss-Prot),   Q62871 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_063139071   ⟸   XM_063283001
- Peptide Label: isoform X3
RefSeq Acc Id: XP_063139072   ⟸   XM_063283002
- Peptide Label: isoform X4
- UniProtKB: Q62873 (UniProtKB/Swiss-Prot),   Q62872 (UniProtKB/Swiss-Prot),   Q62871 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_063139074   ⟸   XM_063283004
- Peptide Label: isoform X6
RefSeq Acc Id: XP_063139075   ⟸   XM_063283005
- Peptide Label: isoform X7
- UniProtKB: Q62873 (UniProtKB/Swiss-Prot),   Q62872 (UniProtKB/Swiss-Prot),   Q62871 (UniProtKB/Swiss-Prot)
Ensembl Acc Id: ENSRNOP00000110714   ⟸   ENSRNOT00000144709
Ensembl Acc Id: ENSRNOP00000101529   ⟸   ENSRNOT00000154744

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q62871-F1-model_v2 AlphaFold Q62871 1-638 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13692134
Promoter ID:EPDNEW_R2658
Type:initiation region
Name:Dync1i2_1
Description:dynein cytoplasmic 1 intermediate chain 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R2659  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0357,817,745 - 57,817,805EPDNEW
RGD ID:13692135
Promoter ID:EPDNEW_R2659
Type:multiple initiation site
Name:Dync1i2_2
Description:dynein cytoplasmic 1 intermediate chain 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R2658  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0357,817,939 - 57,817,999EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620174 AgrOrtholog
BioCyc Gene G2FUF-49473 BioCyc
Ensembl Genes ENSRNOG00000009781 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000047243 ENTREZGENE
  ENSRNOT00000067729 ENTREZGENE
  ENSRNOT00000144709 ENTREZGENE
  ENSRNOT00000154744 ENTREZGENE
Gene3D-CATH 2.130.10.10 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7113840 IMAGE-MGC_LOAD
InterPro DYNC1I1/DYNC1I2 UniProtKB/Swiss-Prot
  Dynein_IC UniProtKB/Swiss-Prot
  WD40/YVTN_repeat-like_dom_sf UniProtKB/Swiss-Prot
  WD40_repeat UniProtKB/Swiss-Prot
  WD40_repeat_dom_sf UniProtKB/Swiss-Prot
MGC_CLONE MGC:93277 IMAGE-MGC_LOAD
NCBI Gene 116659 ENTREZGENE
PANTHER CYTOPLASMIC DYNEIN 1 INTERMEDIATE CHAIN 2 UniProtKB/Swiss-Prot
  DYNEIN INTERMEDIATE CHAIN UniProtKB/Swiss-Prot
Pfam Dynein_IC2 UniProtKB/Swiss-Prot
  WD40 UniProtKB/Swiss-Prot
PhenoGen Dync1i2 PhenoGen
PROSITE WD_REPEATS_2 UniProtKB/Swiss-Prot
  WD_REPEATS_REGION UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000009781 RatGTEx
SMART WD40 UniProtKB/Swiss-Prot
Superfamily-SCOP SSF50978 UniProtKB/Swiss-Prot
UniProt A0ABK0LDV3_RAT UniProtKB/TrEMBL
  A0ABK0M5F7_RAT UniProtKB/TrEMBL
  A0ABZ3NN81_RAT UniProtKB/TrEMBL
  A6HM43 ENTREZGENE, UniProtKB/TrEMBL
  A6HM44 ENTREZGENE, UniProtKB/TrEMBL
  A6HM45 ENTREZGENE, UniProtKB/TrEMBL
  D3ZU74 ENTREZGENE, UniProtKB/TrEMBL
  DC1I2_RAT UniProtKB/Swiss-Prot
  F7FJ03 ENTREZGENE, UniProtKB/TrEMBL
  G3V9V3 ENTREZGENE, UniProtKB/TrEMBL
  Q62871 ENTREZGENE
  Q62872 ENTREZGENE
  Q62873 ENTREZGENE
  Q6AZ35 ENTREZGENE
UniProt Secondary Q62872 UniProtKB/Swiss-Prot
  Q62873 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-02-19 Dync1i2  dynein cytoplasmic 1 intermediate chain 2  Dncic2  dynein, cytoplasmic, intermediate chain 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-11-17 Dncic2  dynein, cytoplasmic, intermediate chain 2    dynein, cytoplasmic, intermediate polypeptide 2  Name updated 1299863 APPROVED
2004-01-09 Dncic2    Dnci2  dynein, cytoplasmic, intermediate polypeptide 2  Symbol updated to reflect Human and Mouse nomenclature 625702 APPROVED
2002-08-07 Dnci2  dynein, cytoplasmic, intermediate polypeptide 2      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_function may bind organelles via interaction with the p150Glued doublet of the dynactic complex 728206
gene_physical_interaction binds with p150Glued via aa 1-123 of dncic2 and aa 200-811 of p150Glued 728206