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Gene: Slc26a1 (solute carrier family 26 member 1) Rattus norvegicus

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Symbol:

Slc26a1

Name:

solute carrier family 26 member 1

RGD ID:

620136

Description:

Enables sulfate:bicarbonate antiporter activity. Involved in sulfate transmembrane transport. Located in basolateral plasma membrane. Human ortholog(s) of this gene implicated in calcium oxalate nephrolithiasis. Orthologous to human SLC26A1 (solute carrier family 26 member 1); INTERACTS WITH 17beta-estradiol 3-benzoate; 2,2',4,4'-Tetrabromodiphenyl ether; 2,3,7,8-tetrachlorodibenzodioxine.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

canalicular sulfate transporter; sat-1; solute carrier family 26 (anion exchanger), member 1; solute carrier family 26 (sulfate transporter), member 1; sulfate anion transporter; sulfate anion transporter 1; sulfate/carbonate antiporter

RGD Orthologs

Alliance Orthologs

More Info

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More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	SLC26A1 (solute carrier family 26 member 1)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, Treefam
Mus musculus (house mouse):	Slc26a1 (solute carrier family 26 (sulfate transporter), member 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Slc26a1 (solute carrier family 26 member 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	SLC26A1 (solute carrier family 26 member 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	SLC26A1 (solute carrier family 26 member 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Slc26a1 (solute carrier family 26 member 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	SLC26A1 (solute carrier family 26 member 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	SLC26A1 (solute carrier family 26 member 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Slc26a1 (solute carrier family 26 member 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus rattus (black rat):	Slc26a1 (solute carrier family 26 member 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Other homologs ²
Homo sapiens (human):	IDUA (alpha-L-iduronidase)	HGNC	OrthoDB
Alliance orthologs ³
Mus musculus (house mouse):	Slc26a1 (solute carrier family 26 (sulfate transporter), member 1)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Homo sapiens (human):	SLC26A1 (solute carrier family 26 member 1)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	slc26a1 (solute carrier family 26 member 1)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	Prestin	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	Prestin	Alliance	DIOPT (OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB)
Saccharomyces cerevisiae (baker's yeast):	YPR003C	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|PANTHER)
Saccharomyces cerevisiae (baker's yeast):	YPR003C	Alliance	DIOPT (OMA\|OrthoFinder)
Caenorhabditis elegans (roundworm):	sulp-1	Alliance	DIOPT (OrthoFinder\|PANTHER\|PhylomeDB)
Caenorhabditis elegans (roundworm):	sulp-2	Alliance	DIOPT (Ensembl Compara\|OMA\|OrthoFinder\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	sulp-3	Alliance	DIOPT (Ensembl Compara\|InParanoid\|OrthoFinder\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	sulp-3	Alliance	DIOPT (InParanoid\|OrthoFinder\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	sulp-4	Alliance	DIOPT (Ensembl Compara\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	sulp-5	Alliance	DIOPT (Ensembl Compara\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	sulp-5	Alliance	DIOPT (InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	sulp-7	Alliance	DIOPT (OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	slc26a1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB)
Xenopus tropicalis (tropical clawed frog):	slc26a1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	14	1,180,465 - 1,190,257 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	14	1,184,649 - 1,190,255 (+)	Ensembl				GRCr8
mRatBN7.2	14	1,040,565 - 1,045,851 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	14	1,040,243 - 1,045,849 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	14	940,390 - 945,676 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	14	2,242,167 - 2,247,453 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	14	938,860 - 944,146 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	14	2,050,805 - 2,056,091 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	14	2,050,483 - 2,056,089 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	14	2,046,346 - 2,051,632 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	14	1,581,589 - 1,586,875 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	14	1,079,905 - 1,085,191 (+)	NCBI		Celera
RGSC_v3.1	14	1,581,266 - 1,586,873 (+)	NCBI
Cytogenetic Map	14	p22	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

calcium oxalate nephrolithiasis (ISO)

Calcium Oxalate Nephrolithiasis 1 (ISO)

genetic disease (ISO)

Hyperoxaluria (ISO)

nephrocalcinosis (ISO)

nephrolithiasis (ISO)

urolithiasis (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(1->4)-beta-D-glucan (ISO)

1,1-dichloroethene (ISO)

17beta-estradiol (ISO)

17beta-estradiol 3-benzoate (EXP)

2,2',4,4'-Tetrabromodiphenyl ether (EXP)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,3,7,8-Tetrachlorodibenzofuran (EXP)

2,4-dibromophenyl 2,4,5-tribromophenyl ether (ISO)

2,4-dinitrotoluene (EXP)

4,4'-diaminodiphenylmethane (ISO)

4,4'-sulfonyldiphenol (ISO)

acetamide (EXP)

aflatoxin B1 (ISO)

ammonium chloride (EXP)

antirheumatic drug (ISO)

aristolochic acid A (EXP)

Azoxymethane (ISO)

Benoxacor (ISO)

benzo[a]pyrene (ISO)

bisphenol A (EXP)

Butylbenzyl phthalate (ISO)

cadmium dichloride (EXP)

cisplatin (ISO)

clofibric acid (EXP)

copper atom (EXP,ISO)

copper(0) (EXP,ISO)

dextran sulfate (ISO)

Diisodecyl phthalate (ISO)

endosulfan (ISO)

epoxiconazole (ISO)

Estradiol dipropionate (EXP)

ethylene glycol (EXP)

eugenol (EXP)

fenthion (ISO)

flavonoids (EXP)

flutamide (EXP)

furan (EXP)

gentamycin (EXP)

inulin (ISO)

N-nitrosodiethylamine (EXP)

okadaic acid (ISO)

p-toluidine (EXP)

paracetamol (EXP,ISO)

perfluorohexanesulfonic acid (ISO)

perfluorooctane-1-sulfonic acid (ISO)

phenobarbital (ISO)

pirinixic acid (EXP,ISO)

progesterone (EXP)

propanal (ISO)

resveratrol (ISO)

tauroursodeoxycholic acid (EXP)

tetrachloromethane (EXP,ISO)

thioacetamide (EXP)

titanium dioxide (ISO)

triptonide (ISO)

urethane (ISO)

ursodeoxycholic acid (EXP)

valproic acid (ISO)

vancomycin (ISO)

zidovudine (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

bicarbonate transport (IEA)

chloride transmembrane transport (IBA,IEA)

chloride transport (ISO)

monoatomic ion transmembrane transport (IEA)

monoatomic ion transport (IEA)

oxalate transport (IEA,ISO)

sulfate transmembrane transport (IBA,IDA,IEA,ISO)

transmembrane transport (IEA)

Cellular Component

basolateral plasma membrane (IDA,IEA,ISO)

membrane (IEA)

plasma membrane (IBA,IEA,ISO)

Molecular Function

antiporter activity (IEA)

chloride transmembrane transporter activity (IEA,ISO,ISS)

chloride:bicarbonate antiporter activity (IBA)

oxalate transmembrane transporter activity (IBA,IEA,ISO,ISS)

protein binding (ISO)

secondary active sulfate transmembrane transporter activity (IEA)

solute:inorganic anion antiporter activity (IDA,IEA,ISO)

sulfate transmembrane transporter activity (IBA,IEA,ISO)

sulfate:bicarbonate antiporter activity (IDA,IEA,ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Functional expression cloning of the canalicular sulfate transport system of rat hepatocytes.	Bissig M, etal., J Biol Chem 1994 Jan 28;269(4):3017-21.
2.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
4.	Immunolocalization of sat-1 sulfate/oxalate/bicarbonate anion exchanger in the rat kidney.	Karniski LP, etal., Am J Physiol. 1998 Jul;275(1):F79-87. doi: 10.1152/ajprenal.1998.275.1.F79.
5.	Ability of sat-1 to transport sulfate, bicarbonate, or oxalate under physiological conditions.	Krick W, etal., Am J Physiol Renal Physiol. 2009 Jul;297(1):F145-54. doi: 10.1152/ajprenal.90401.2008. Epub 2009 Apr 15.
6.	Bicarbonate sulfate exchange in canalicular rat liver plasma membrane vesicles.	Meier PJ, etal., Am J Physiol. 1987 Oct;253(4 Pt 1):G461-8. doi: 10.1152/ajpgi.1987.253.4.G461.
7.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
8.	Electronic Transfer of LocusLink and RefSeq Data	NCBI rat LocusLink and RefSeq merged data July 26, 2002
9.	Localization of the sulfate/anion exchanger in the rat liver.	Quondamatteo F, etal., Am J Physiol Gastrointest Liver Physiol. 2006 May;290(5):G1075-81. doi: 10.1152/ajpgi.00492.2005. Epub 2005 Dec 15.
10.	GOA pipeline	RGD automated data pipeline
11.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
12.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
13.	Glyoxylate is a substrate of the sulfate-oxalate exchanger, sat-1, and increases its expression in HepG2 cells.	Schnedler N, etal., J Hepatol. 2011 Mar;54(3):513-20. doi: 10.1016/j.jhep.2010.07.036. Epub 2010 Sep 19.

Additional References at PubMed

PMID:12217875	PMID:12477932	PMID:12590734	PMID:15070814	PMID:19002488	PMID:26671068

Genomics

Comparative Map Data

Slc26a1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	14	1,180,465 - 1,190,257 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	14	1,184,649 - 1,190,255 (+)	Ensembl				GRCr8
mRatBN7.2	14	1,040,565 - 1,045,851 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	14	1,040,243 - 1,045,849 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	14	940,390 - 945,676 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	14	2,242,167 - 2,247,453 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	14	938,860 - 944,146 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	14	2,050,805 - 2,056,091 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	14	2,050,483 - 2,056,089 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	14	2,046,346 - 2,051,632 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	14	1,581,589 - 1,586,875 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	14	1,079,905 - 1,085,191 (+)	NCBI		Celera
RGSC_v3.1	14	1,581,266 - 1,586,873 (+)	NCBI
Cytogenetic Map	14	p22	NCBI

SLC26A1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	4	978,991 - 993,404 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	4	979,073 - 997,659 (-)	Ensembl			hg38	GRCh38
GRCh37	4	972,823 - 987,192 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	4	962,861 - 977,224 (-)	NCBI	Build 36	Build 36	hg18	NCBI36
Build 34	4	971,274 - 977,013	NCBI
Celera	4	909,807 - 924,170 (-)	NCBI		Celera
Cytogenetic Map	4	p16.3	NCBI
HuRef	4	944,081 - 958,446 (-)	NCBI		HuRef
CHM1_1	4	972,645 - 987,011 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	4	977,118 - 991,535 (-)	NCBI		T2T-CHM13v2.0

Slc26a1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	5	108,817,744 - 108,826,246 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	5	108,817,744 - 108,823,435 (-)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	5	108,669,878 - 108,678,380 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	5	108,669,878 - 108,675,569 (-)	Ensembl			mm10	GRCm38
MGSCv37	5	109,099,560 - 109,104,668 (-)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	5	108,910,180 - 108,915,871 (-)	NCBI		MGSCv36	mm8
Celera	5	105,792,486 - 105,798,328 (-)	NCBI		Celera
Cytogenetic Map	5	F	NCBI
cM Map	5	53.24	NCBI

Slc26a1
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955514	475,731 - 479,616 (-)	Ensembl
ChiLan1.0	NW_004955514	476,062 - 484,710 (-)	NCBI	ChiLan1.0	ChiLan1.0

SLC26A1
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	3	1,305,579 - 1,320,531 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	4	1,273,068 - 1,293,527 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	4	1,102,938 - 1,112,987 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	4	1,021,157 - 1,026,402 (-)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	4	1,012,920 - 1,026,402 (-)	Ensembl			panPan2	panpan1.1

SLC26A1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	3	91,528,045 - 91,534,104 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	3	91,485,270 - 91,534,115 (+)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	3	93,996,593 - 94,000,624 (+)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	3	92,526,061 - 92,532,133 (+)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	3	92,482,112 - 92,532,144 (+)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	3	91,699,880 - 91,705,945 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	3	91,752,838 - 91,758,900 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	3	92,136,646 - 92,142,712 (+)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Slc26a1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405285	68,507,763 - 68,519,289 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936477	22,208,451 - 22,213,592 (+)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936477	22,209,445 - 22,213,592 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

SLC26A1
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	8	335,427 - 342,444 (-)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	8	335,420 - 345,955 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1

SLC26A1
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	27	47,787,201 - 47,802,834 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	27	47,789,705 - 47,793,743 (+)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666808	62,915 - 72,446 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Slc26a1
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624755	26,164,795 - 26,169,365 (+)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624755	26,162,730 - 26,168,443 (+)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Slc26a1
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	11	18,461,758 - 18,465,817 (-)	NCBI		Rrattus_CSIRO_v1

Variants

Variants in Slc26a1
29 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	281
Count of miRNA genes:	182
Interacting mature miRNAs:	202
Transcripts:	ENSRNOT00000000047
Prediction methods:	Microtar, Miranda, Rnahybrid
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
7411573	Bw139	Body weight QTL 139	4.7	0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	14	1	40068101	Rat
9589814	Gluco67	Glucose level QTL 67	4.54	0.001	blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	14	1	40068101	Rat
634352	Apr6	Acute phase response QTL 6	3.7		blood interleukin-6 amount (VT:0008595)	plasma interleukin-6 level (CMO:0001927)	14	1	41415516	Rat
71115	Niddm15	Non-insulin dependent diabetes mellitus QTL 15	4.8		blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	14	1	11334906	Rat
71117	Niddm17	Non-insulin dependent diabetes mellitus QTL 17	2.35		blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	14	1	17877928	Rat
70204	Niddm20	Non-insulin dependent diabetes mellitus QTL 20	5.1	0.000008	blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	14	1	31893212	Rat

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
16	12	65	160	91	90	59	85	59	6	347	183	11	139	81	90	31	17	17

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_022287	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063273574	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC117047	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC085735	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH474079	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000014	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	L23413	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000000047 ⟹ ENSRNOP00000000047

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	14	1,184,649 - 1,190,255 (+)	Ensembl
mRatBN7.2 Ensembl	14	1,040,243 - 1,045,849 (+)	Ensembl
Rnor_6.0 Ensembl	14	2,050,483 - 2,056,089 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000111929 ⟹ ENSRNOP00000095191

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	14	1,185,663 - 1,190,255 (+)	Ensembl
mRatBN7.2 Ensembl	14	1,040,879 - 1,045,849 (+)	Ensembl

RefSeq Acc Id:

NM_022287 ⟹ NP_071623

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	14	1,184,971 - 1,190,257 (+)	NCBI
mRatBN7.2	14	1,040,565 - 1,045,851 (+)	NCBI
Rnor_6.0	14	2,050,805 - 2,056,091 (+)	NCBI
Rnor_5.0	14	2,046,346 - 2,051,632 (+)	NCBI
RGSC_v3.4	14	1,581,589 - 1,586,875 (+)	RGD
Celera	14	1,079,905 - 1,085,191 (+)	RGD

Sequence:

show sequence

GCCGGCCTGGTGTCCCAGATTAGCCAAAGAGCCTGGTGTGACAGGATGGATGCTTCTCCTGAGC
CCCCGCAGAAGGGCGGGACACTGGTACTGGTCCGACGGCAGCCCCCTGTGTCCCAGGGCTTGCT
GGAAACACTGAAGGCCAGGCTGAAGAAGAGCTGCACCTGCAGTATGCCATGCGCTCAGGCTCTG
GTGCAAGGTCTGTTTCCTGTCATACGCTGGCTGCCCCAGTACCGCCTTAAGGAATACCTGGCAG
GTGATGTCATGTCGGGATTGGTCATTGGCATTATCCTGGTGCCACAGGCCATAGCCTACTCACT
GCTGGCTGGGTTGCAGCCCATCTACAGTCTCTACACTTCCTTCTTCGCCAACCTTATCTACTTC
CTCATGGGTACCTCCCGCCACGTTAATGTGGGCATCTTCAGCCTGCTGTGTCTCATGGTGGGTC
AGGTGGTGGACCGAGAACTCCAGTTGGCTGGCTTTGACCCCTCCCAGGATTCTCTAGGGCCCGG
GAACAATGACAGCACCCTCAACAACACAGCCACACTGACAGTTGGGCTACAGGACTGTGGGCGG
GACTGCCATGCCATTCGTATCGCCACTGCCCTCACTCTGATGGCCGGGCTTTATCAGGTCCTCA
TGGGGATCCTCCGGCTGGGCTTCGTGTCTACCTATCTCTCGCAACCCCTGCTCGATGGCTTTGC
TATGGGAGCTTCTGTGACCATCTTGACTTCTCAGGCTAAACACCTGCTGGGCGTGCGGATCCCT
CGGCACCAGGGCCTAGGCATGGTGATCCACACTTGGCTGAGCTTGCTGCAGAACGTGGGACAGG
CTAATCTGTGTGATGTGGTCACCAGTGCCGTGTGCCTGGCAGTGCTGCTGACAGCTAAGGAACT
CTCGGATCGCTATCGACACTATCTGAAAGTGCCAGTGCCCACAGAGCTATTAGTTATTGTGGTG
GCCACGATTGCGTCCCATTTTGGACAGCTCCATACACGGTTTGGCTCGAGTGTGGCCGGCAACA
TTCCCACTGGTTTTGTGGCCCCACAGATACCAGACCCTAAGATAATGTGGAGTGTGGCCCTGGA
TGCCATGTCCCTGGCCCTCGTGGGCTCAGCCTTCTCCATCTCCTTGGCAGAAATGTTTGCACGT
AGTCATGGCTACTCTGTCAGTGCCAACCAAGAGCTGCTAGCTGTGGGCTGTTGCAACGTGCTGC
CTGCCTTCTTCCACTGTTTTGCCACTAGTGCTGCTCTGTCCAAAACTCTGGTGAAGATAGCCAC
TGGCTGCCAGACCCAGTTGTCCAGTGTGGTCAGTGCTGCTGTGGTGTTGCTGGTGCTGCTGGTG
CTGGCGCCATTGTTTCACGATCTGCAGCGGTGTGTGTTAGCTTGCATCATTGTCGTCAGCCTGA
GGGGGGCGCTGCGCAAGGTGAAGGATCTCCCACAACTTTGGCGGCTAAGCCCTGCGGACGCACT
GGTCTGGGTGGCTACTGCAGCGACCTGTGTTCTAGTCAGCATCGAGGCTGGGCTATTAGCTGGG
GTGTTCTTCTCACTGCTCAGCCTGGCAGGCCGCACGCAGCGTCCACGGGCTGCCCTTCTGGCTC
GAATTGGAGACTCGACCTTCTATGAGGATGCTGCTGAGTTTGAGGGCCTCCTGCCCCCGCCCGA
GGTGCGAGTGTTCCGTTTCACAGGTCCGCTCTACTATGCCAACAAGGATTTCTTCCTTCGGTCA
CTCTACAGTCTGACAGGGCTGGATGCTGGGTACTCAGCCACCAGGAAGGATCGGGGCACAGAGG
TGGGTGTCAGTAACAGAAGTCTTGTTGACCGCAAGGATCTGGGTTCAGTGAGCAGTGGGGATGG
GCTGGTTGTACCCCTGGCATTTGGTTTCCACACAGTGGTCATTGACTGTGCACCACTGCTGTTC
CTGGATGTGGCTGGCATGGCCACATTGAAGGACCTGCGCAAAAACTACAGGGCCCTGGACATCA
CCCTGCTTCTGGCTTGCTGCAGTCCCTCAGTGAGAGACACACTGAGAAAAGGGGGCTTCCTTGG
GGAAGACCAGGGAACTGAAGAGGAGCTGCTGTTCCCCAGTGTACACAGCGCTGTGGAGACAGCA
TGTGCCCGCCGTGAGGAGCTGATGGCTGCTGACTCTGCCCTCTAGCAGGGCCCGCTTCCTCAAG
AGCCAAGACCTGTGTCCACGAGCCAGTCCTGAGCTCTTTTGTAGGAGTGACATGAATGATAAAG
TCATTATAGATAAATCCTTGGACCGCCTTTGCCCTGGAGAAGCCAGGGAACTCCAAGTAGGAAA
GGAAAGTGCAGTACCCTTAACACATTGGAGGATTCCAAACATTCAGTGATTGAGGCGCTCTACC
TCTGAGCCCACTGCTGCCCCCTGGTGCCTATTCAACCCTAGTAGTTGCACCCACACACATGATT
CCCTCAGCCAACACAGTGCCCAGTTTGATAGTCTGTTTATGTTGTCATCTGAAACAGAGTCCTG
CAAATTATATGACCTCCATGATGCCAAAAGGACACTTTCCCATTCCCTGAACCATCGGGTACCA
GATGTGAGCTGAATATGTGGCCACACCTCAAGGGTCTGAATTTCCGAAAGGCCTCCTTAGGCCT
GGTGCTCATCTTGATTGGACCCTTGCAAAGGCAGCCACCTGCTCCAGAGTCACAGTCCAGTGTC
ACTGTCTAACCGATGTGACTGACATAACCTCAACCTGACTTTCGGGCACAATGTCCCAATACAG
CTTATACTGGTAACCACAACGTGGCGTATGTATGGTACAAAGCCAGGCACAGTAGACACTTACC
CCATTCTGCTGTACTTCTAAGAAAACCTCAGGAGGAAACCACCTGTGCTCCATCCAGGGCCTGC
CTTTGGCACAGCCAAGCAGACATTCCCCTCCTCCTCTGCCCAACAGGATGCTCTAACTGGAAGC
ACACCCCAGCCCTGTGCACTACCATGATTCTCCCCCACCCACAGCCCAGCATTGTGTTCCACAG
CTGGCCCCAAAAACGTCAGCTCCACCATCTCGGCTCTCTTAAAACAAGCTCTGACCAGCAATTC
CCAGGGTACCCATTTCAGCGTCACCCACCTGGCTGTGATGAGGTCCAGCAGCCAGTGTATCCGG
ACCTGCTCAATGCCACTGTGAGGCACAGCACCTATGTAGGCAAGGTTCAGTTGCTGGTCCCAAC
TAAGGTCGTACTGGTCAGCCTGGTCGTGAGGCAGTGGGGGGCTAGGGATAGGACAAAGAAGTGA
AGTGTTTGTCCTAAGCAGGGGCCTGCATCATACCAGACTTTACACATGTTATCACCTGACTACC
TAGACCCTTGAGGATGAACTGTGTATCTCCAGAATGTATGATAAAGTAGCCCACTAACCAGAAA
AAAAAAAAAAAAAAAAAAAAAA

hide sequence

RefSeq Acc Id:

XM_063273574 ⟹ XP_063129644

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	14	1,180,465 - 1,190,257 (+)	NCBI

Protein Sequences


Protein RefSeqs	NP_071623	(Get FASTA)	NCBI Sequence Viewer
	XP_063129644	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAA17545	(Get FASTA)	NCBI Sequence Viewer
	AAH85735	(Get FASTA)	NCBI Sequence Viewer
	EDL84026	(Get FASTA)	NCBI Sequence Viewer
	EDL84027	(Get FASTA)	NCBI Sequence Viewer
	EDL84028	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000000047
GenBank Protein	P45380	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

NP_071623 ⟸ NM_022287

- UniProtKB:

P45380 (UniProtKB/Swiss-Prot), Q5RKK1 (UniProtKB/TrEMBL), A6KPE0 (UniProtKB/TrEMBL), F7EVA2 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MDASPEPPQKGGTLVLVRRQPPVSQGLLETLKARLKKSCTCSMPCAQALVQGLFPVIRWLPQYR
LKEYLAGDVMSGLVIGIILVPQAIAYSLLAGLQPIYSLYTSFFANLIYFLMGTSRHVNVGIFSL
LCLMVGQVVDRELQLAGFDPSQDSLGPGNNDSTLNNTATLTVGLQDCGRDCHAIRIATALTLMA
GLYQVLMGILRLGFVSTYLSQPLLDGFAMGASVTILTSQAKHLLGVRIPRHQGLGMVIHTWLSL
LQNVGQANLCDVVTSAVCLAVLLTAKELSDRYRHYLKVPVPTELLVIVVATIASHFGQLHTRFG
SSVAGNIPTGFVAPQIPDPKIMWSVALDAMSLALVGSAFSISLAEMFARSHGYSVSANQELLAV
GCCNVLPAFFHCFATSAALSKTLVKIATGCQTQLSSVVSAAVVLLVLLVLAPLFHDLQRCVLAC
IIVVSLRGALRKVKDLPQLWRLSPADALVWVATAATCVLVSIEAGLLAGVFFSLLSLAGRTQRP
RAALLARIGDSTFYEDAAEFEGLLPPPEVRVFRFTGPLYYANKDFFLRSLYSLTGLDAGYSATR
KDRGTEVGVSNRSLVDRKDLGSVSSGDGLVVPLAFGFHTVVIDCAPLLFLDVAGMATLKDLRKN
YRALDITLLLACCSPSVRDTLRKGGFLGEDQGTEEELLFPSVHSAVETACARREELMAADSAL

hide sequence

Ensembl Acc Id:

ENSRNOP00000000047 ⟸ ENSRNOT00000000047

Ensembl Acc Id:

ENSRNOP00000095191 ⟸ ENSRNOT00000111929

RefSeq Acc Id:	XP_063129644 ⟸ XM_063273574
- Peptide Label:	isoform X1
- UniProtKB:	P45380 (UniProtKB/Swiss-Prot), A6KPE0 (UniProtKB/TrEMBL), F7EVA2 (UniProtKB/TrEMBL), Q5RKK1 (UniProtKB/TrEMBL)

Protein Domains

STAS

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-P45380-F1-model_v2	AlphaFold	P45380	1-703	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13699143

Promoter ID:

EPDNEW_R9667

Type:

initiation region

Name:

Slc26a1_1

Description:

solute carrier family 26 member 1

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	14	2,050,725 - 2,050,785	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:620136	AgrOrtholog
BioCyc Gene	G2FUF-16684	BioCyc
Ensembl Genes	ENSRNOG00000000041	Ensembl, ENTREZGENE
Ensembl Transcript	ENSRNOT00000000047	ENTREZGENE
Gene3D-CATH	3.30.750.24	UniProtKB/Swiss-Prot
IMAGE_CLONE	IMAGE:7108820	IMAGE-MGC_LOAD
InterPro	S04_transporter_CS	UniProtKB/Swiss-Prot
	SLC26A/SulP_dom	UniProtKB/Swiss-Prot
	SLC26A/SulP_fam	UniProtKB/Swiss-Prot
	STAS_dom	UniProtKB/Swiss-Prot
	STAS_dom_sf	UniProtKB/Swiss-Prot
MGC_CLONE	MGC:93448	IMAGE-MGC_LOAD
NCBI Gene	64076	ENTREZGENE
PANTHER	PTHR11814	UniProtKB/Swiss-Prot
Pfam	STAS	UniProtKB/Swiss-Prot
	Sulfate_transp	UniProtKB/Swiss-Prot
PhenoGen	Slc26a1	PhenoGen
PROSITE	SLC26A	UniProtKB/Swiss-Prot
	STAS	UniProtKB/Swiss-Prot
RatGTEx	ENSRNOG00000000041	RatGTEx
Superfamily-SCOP	SSF52091	UniProtKB/Swiss-Prot
UniProt	A0A8I6B257_RAT	UniProtKB/TrEMBL
	A6KPE0	ENTREZGENE, UniProtKB/TrEMBL
	F7EVA2	ENTREZGENE, UniProtKB/TrEMBL
	P45380	ENTREZGENE
	Q5RKK1	ENTREZGENE
	S26A1_RAT	UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2016-03-09	Slc26a1	solute carrier family 26 member 1	Slc26a1	solute carrier family 26 (anion exchanger), member 1	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2013-08-02	Slc26a1	solute carrier family 26 (anion exchanger), member 1	Slc26a1	solute carrier family 26 (sulfate transporter), member 1	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2004-02-26	Slc26a1	solute carrier family 26 (sulfate transporter), member 1			Symbol and Name status set to approved	625702	APPROVED
2003-05-07	Slc26a1	solute carrier family 26 (sulfate transporter), member 1	sat-1	sulfate anion transporter	Symbol and Name updated to reflect Human and Mouse nomenclature	628472	PROVISIONAL
2002-08-07	sat-1	sulfate anion transporter			Symbol and Name status set to provisional	70820	PROVISIONAL

RGD Curation Notes

Note Type	Note	Reference
gene_domains	contains 12 putative transmembrane spanning domains	730015
gene_process	channel functions in Na(+)-independent sulfate uptake	730015

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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