Rab27b (RAB27B, member RAS oncogene family) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Behavioral & Substance Use Disorder Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: Rab27b (RAB27B, member RAS oncogene family) Rattus norvegicus
Analyze
Symbol: Rab27b
Name: RAB27B, member RAS oncogene family
RGD ID: 620114
Description: Enables G protein activity. Involved in anterograde axonal protein transport; regulation of exocytosis; and synaptic vesicle endocytosis. Located in apical plasma membrane and zymogen granule membrane. Is active in synaptic vesicle membrane. Orthologous to human RAB27B (RAB27B, member RAS oncogene family); INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: LOC108348810; ras-related protein Rab-27B; uncharacterized LOC108348810
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81865,870,230 - 66,069,597 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1865,876,342 - 66,067,700 (-)EnsemblGRCr8
mRatBN7.21863,597,554 - 63,794,124 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1863,600,937 - 63,757,180 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1865,691,199 - 65,753,434 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01866,369,540 - 66,432,265 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01864,251,252 - 64,313,623 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01868,486,006 - 68,644,595 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1868,488,942 - 68,551,558 (-)Ensemblrn6Rnor6.0
Rnor_5.01867,638,697 - 67,796,869 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41866,682,627 - 66,747,813 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1861,692,971 - 61,755,141 (-)NCBICelera
RGSC_v3.11866,755,827 - 66,821,014 (-)NCBI
Cytogenetic Map18q12.1NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
1,2-dimethylhydrazine  (ISO)
14-Deoxy-11,12-didehydroandrographolide  (ISO)
17beta-estradiol  (EXP,ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2-palmitoylglycerol  (ISO)
4,4'-sulfonyldiphenol  (ISO)
6-propyl-2-thiouracil  (EXP)
8-Br-cAMP  (ISO)
afimoxifene  (ISO)
aflatoxin B1  (ISO)
ammonium chloride  (EXP)
antirheumatic drug  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
Azoxymethane  (ISO)
benzo[a]pyrene  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
butanal  (ISO)
carbon nanotube  (ISO)
carmustine  (ISO)
chloropicrin  (ISO)
chloroprene  (ISO)
choline  (ISO)
Cuprizon  (EXP)
dextran sulfate  (ISO)
diarsenic trioxide  (ISO)
Dibutyl phosphate  (ISO)
disodium selenite  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
ethanol  (ISO)
flavonoids  (EXP)
fluvastatin  (ISO)
folic acid  (ISO)
fonofos  (ISO)
formaldehyde  (ISO)
gentamycin  (EXP)
GSK-J4  (ISO)
L-methionine  (ISO)
lead(0)  (ISO)
methyl methanesulfonate  (ISO)
methylmercury chloride  (ISO)
nickel sulfate  (ISO)
okadaic acid  (ISO)
parathion  (ISO)
pentachlorophenol  (ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phenol red  (ISO)
potassium chromate  (ISO)
progesterone  (ISO)
rotenone  (EXP,ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
SB 431542  (ISO)
Securinine  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
Soman  (EXP)
temozolomide  (ISO)
terbufos  (ISO)
testosterone  (EXP,ISO)
tetrachloromethane  (ISO)
titanium dioxide  (ISO)
trichostatin A  (ISO)
triphenyl phosphate  (ISO)
troglitazone  (ISO)
valproic acid  (ISO)
zalcitabine  (EXP)
zinc atom  (ISO)
zinc(0)  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function
G protein activity  (IEA,IMP)
GDP binding  (IEA,ISO,ISS)
GTP binding  (IBA,IEA,ISO,ISS)
GTPase activity  (IBA,IEA,ISO,ISS)
hydrolase activity  (IEA)
myosin V binding  (IEA,ISO)
nucleotide binding  (IEA)
protein binding  (IPI,ISO)
protein domain specific binding  (IEA,ISO)

References

References - curated
# Reference Title Reference Citation
1. Rab27b localizes to zymogen granules and regulates pancreatic acinar exocytosis. Chen X, etal., Biochem Biophys Res Commun 2004 Oct 29;323(4):1157-62.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. JIP3 mediates TrkB axonal anterograde transport and enhances BDNF signaling by directly bridging TrkB with kinesin-1. Huang SH, etal., J Neurosci. 2011 Jul 20;31(29):10602-14. doi: 10.1523/JNEUROSCI.0436-11.2011.
5. Functional involvement of Noc2, a Rab27 effector, in rat parotid acinar cells. Imai A, etal., Arch Biochem Biophys. 2006 Nov 15;455(2):127-35. Epub 2006 Oct 9.
6. The small GTPase Rab27B regulates amylase release from rat parotid acinar cells. Imai A, etal., J Cell Sci. 2004 Apr 15;117(Pt 10):1945-53. Epub 2004 Mar 23.
7. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
8. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
9. Quantitative analysis of synaptic vesicle Rabs uncovers distinct yet overlapping roles for Rab3a and Rab27b in Ca2+-triggered exocytosis. Pavlos NJ, etal., J Neurosci. 2010 Oct 6;30(40):13441-53. doi: 10.1523/JNEUROSCI.0907-10.2010.
10. GOA pipeline RGD automated data pipeline
11. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
12. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:9066979   PMID:14724135   PMID:15357836   PMID:16880209   PMID:18940604   PMID:19199708   PMID:19460344   PMID:19966785   PMID:20937701   PMID:22157766   PMID:23376485   PMID:23533145  
PMID:27325508   PMID:29167152   PMID:30771381  


Genomics

Comparative Map Data
Rab27b
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81865,870,230 - 66,069,597 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1865,876,342 - 66,067,700 (-)EnsemblGRCr8
mRatBN7.21863,597,554 - 63,794,124 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1863,600,937 - 63,757,180 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1865,691,199 - 65,753,434 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01866,369,540 - 66,432,265 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01864,251,252 - 64,313,623 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01868,486,006 - 68,644,595 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1868,488,942 - 68,551,558 (-)Ensemblrn6Rnor6.0
Rnor_5.01867,638,697 - 67,796,869 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41866,682,627 - 66,747,813 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1861,692,971 - 61,755,141 (-)NCBICelera
RGSC_v3.11866,755,827 - 66,821,014 (-)NCBI
Cytogenetic Map18q12.1NCBI
RAB27B
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381854,717,857 - 54,895,516 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1854,717,857 - 54,895,516 (+)Ensemblhg38GRCh38
GRCh371852,385,088 - 52,562,747 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361850,646,838 - 50,708,210 (+)NCBIBuild 36Build 36hg18NCBI36
Build 341850,646,837 - 50,708,205NCBI
Celera1849,213,386 - 49,274,789 (+)NCBICelera
Cytogenetic Map18q21.2NCBI
HuRef1849,204,866 - 49,271,963 (+)NCBIHuRef
CHM1_11852,490,951 - 52,557,996 (+)NCBICHM1_1
T2T-CHM13v2.01854,920,965 - 55,098,601 (+)NCBIT2T-CHM13v2.0
Rab27b
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391870,112,202 - 70,274,704 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1870,112,202 - 70,274,676 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381869,979,131 - 70,141,633 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1869,979,131 - 70,141,605 (-)Ensemblmm10GRCm38
MGSCv371870,138,785 - 70,301,244 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361870,109,025 - 70,178,955 (-)NCBIMGSCv36mm8
Celera1871,270,210 - 71,430,343 (-)NCBICelera
Cytogenetic Map18E2NCBI
cM Map1843.89NCBI
Rab27b
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540239,357,500 - 39,415,530 (+)Ensembl
ChiLan1.0NW_00495540239,357,500 - 39,415,530 (+)NCBIChiLan1.0ChiLan1.0
RAB27B
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21772,246,198 - 72,420,789 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11857,938,829 - 58,113,400 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01848,099,912 - 48,274,416 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11851,435,717 - 51,610,156 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1851,542,842 - 51,604,061 (+)EnsemblpanPan2panpan1.1
RAB27B
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1120,695,100 - 20,832,745 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl120,700,514 - 20,832,975 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha121,679,208 - 21,816,880 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0120,580,907 - 20,718,800 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl120,582,171 - 20,718,762 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1120,634,374 - 20,771,706 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0120,529,314 - 20,667,225 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0120,801,076 - 20,938,844 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Rab27b
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494433,802,183 - 33,937,163 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364979,039,546 - 9,098,039 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049364979,039,552 - 9,176,182 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
RAB27B
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1104,241,571 - 104,417,084 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11104,241,500 - 104,418,721 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21114,582,754 - 114,759,909 (+)NCBISscrofa10.2Sscrofa10.2susScr3
RAB27B
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11824,809,497 - 24,975,765 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1824,814,626 - 24,875,818 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_023666060559,919 - 728,023 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Rab27b
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624792307,608 - 363,568 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_004624792166,846 - 368,906 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Rab27b
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11561,092,723 - 61,282,292 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Rab27b
1227 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:16
Count of miRNA genes:16
Interacting mature miRNAs:16
Transcripts:ENSRNOT00000016369
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1331733Bp233Blood pressure QTL 2333.97196arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)182507112683910656Rat
1331730Scl27Serum cholesterol level QTL 273.826blood HDL cholesterol amount (VT:0000184)serum high density lipoprotein cholesterol level (CMO:0000361)185449080186134022Rat
1331741Bp232Blood pressure QTL 2323.59112arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)182349405785487725Rat
1331742Bp228Blood pressure QTL 2283.88752arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)183161050577371277Rat
1298072Cia26Collagen induced arthritis QTL 263.6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)186438376279484311Rat
1300125Rf26Renal function QTL 263.2urine potassium amount (VT:0010539)urine potassium excretion rate (CMO:0000761)185335052168120379Rat
631834Sach3Saccharin preference QTL 33.90.01consumption behavior trait (VT:0002069)calculated saccharin drink intake volume (CMO:0001600)183857591983575919Rat
12904668Bw188Body weight QTL 1880.03body mass (VT:0001259)body weight (CMO:0000012)182682218671822186Rat
12904669Cm125Cardiac mass QTL 1250.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)182682218671822186Rat
6893683Bw110Body weight QTL 1102.70.002body mass (VT:0001259)body weight (CMO:0000012)184562030686134022Rat
12904670Cm126Cardiac mass QTL 1260.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)182682218671822186Rat
7794793Mcs34Mammary carcinoma susceptibility QTL 341.54mammary gland integrity trait (VT:0010552)mammary tumor incidence/prevalence measurement (CMO:0000946)186563556785897775Rat
12904677Kidm72Kidney mass QTL 720.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)182682218671822186Rat
9589041Epfw12Epididymal fat weight QTL 1217.080.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)184891573786134022Rat
8694432Bw165Body weight QTL 1653.810.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)184891573786134022Rat
12904673Cm127Cardiac mass QTL 1270.005heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)182682218671822186Rat
12904675Am19Aortic mass QTL 190.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)182682218671822186Rat
1331774Bp226Blood pressure QTL 2264.41065arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)183161050577371277Rat
9589816Gluco68Glucose level QTL 687.250.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)183199089176990891Rat
1331770Bp234Blood pressure QTL 2343.807arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)184562030686134022Rat
2301969Bp324Blood pressure QTL 3244.05arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)186198220476619168Rat
2303120Mamtr8Mammary tumor resistance QTL 80.001mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)183161050585493247Rat
1578667Bss21Bone structure and strength QTL 213.5femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)181206648285493247Rat
12880368Bw187Body weight QTL 1870.045body mass (VT:0001259)body weight (CMO:0000012)183337915878379158Rat
724542Kidm2Kidney mass QTL 22.6kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)186144685386134022Rat
61367Iddm4Insulin dependent diabetes mellitus QTL 42.330.0074blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)184046238385462383Rat
1359020Ppulsi2Prepulse inhibition QTL 22.71prepulse inhibition trait (VT:0003088)acoustic startle response measurement (CMO:0001519)185449080176272247Rat
2312600Bp341Blood pressure QTL 3410.05arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)186160038472538878Rat
1331752Bw27Body weight QTL 272.963body mass (VT:0001259)body weight (CMO:0000012)185449080168120379Rat
9590318Scort22Serum corticosterone level QTL 227.640.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)183199089176990891Rat
1578661Bss20Bone structure and strength QTL 203.7femur morphology trait (VT:0000559)femoral neck cross-sectional area (CMO:0001697)181206648285493247Rat
1331754Bp230Blood pressure QTL 2304.61609arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)181564228086134022Rat
12904069Cm123Cardiac mass QTL 1230.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)183337915878379158Rat
1331798Bp224Blood pressure QTL 2243.53873arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)183161050577371277Rat
12904070Cm124Cardiac mass QTL 1240.01heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)183337915878379158Rat
2303584Gluco55Glucose level QTL 552blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)185079521286134022Rat
12904071Am18Aortic mass QTL 180.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)183337915878379158Rat
2301413Bp318Blood pressure QTL 3180.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)182682218671822186Rat
61383Bp47Blood pressure QTL 4717.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)183152278376522783Rat
12904067Cm122Cardiac mass QTL 1220.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)183337915878379158Rat
61384Bp48Blood pressure QTL 4819.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)186289225779484461Rat
2301417Bp319Blood pressure QTL 3190.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)183337915878379158Rat
12904073Kidm71Kidney mass QTL 710.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)183337915878379158Rat
738008Hcar14Hepatocarcinoma resistance QTL 144.3liver integrity trait (VT:0010547)liver nonremodeling tumorous lesion number (CMO:0001462)185782524385493247Rat
1331776Bp225Blood pressure QTL 2252.829arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)183161050577371277Rat
631518Bw11Body weight QTL 112.8body mass (VT:0001259)body weight (CMO:0000012)183612162681121626Rat
1641923Colcr8Colorectal carcinoma resistance QTL 83.10.0014intestine integrity trait (VT:0010554)poorly differentiated malignant colorectal tumor number (CMO:0002076)183199089176990891Rat
8694366Abfw8Abdominal fat weight QTL 86.380.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)184891573786134022Rat
631509Sald2Serum aldosterone level QTL 22.9blood aldosterone amount (VT:0005346)serum aldosterone level (CMO:0000487)182641582171415821Rat
631274Sprol1Serum protein level QTL 15.3blood total protein amount (VT:0005567)serum total protein level (CMO:0000661)183164450879484311Rat
1358193Emca2Estrogen-induced mammary cancer QTL 21.6mammary gland integrity trait (VT:0010552)post-insult time to mammary tumor formation (CMO:0000345)186584644786134022Rat
1598832Glom11Glomerulus QTL 112.9kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)185326667186134022Rat
1600373Mamtr6Mammary tumor resistance QTL 6mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)181955353285493247Rat
8694378Bw157Body weight QTL 1573.590.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)183199089176990891Rat
2303571Bw92Body weight QTL 923body mass (VT:0001259)body weight (CMO:0000012)185079521286134022Rat
631675Iddm15Insulin dependent diabetes mellitus QTL 15urine glucose amount (VT:0001758)percentage of study population developing diabetes mellitus during a period of time (CMO:0001114)186289225779484461Rat
61429Cia17Collagen induced arthritis QTL 174.6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)183161050572538878Rat
7411719Strs5Sensitivity to stroke QTL 59.4cerebrum integrity trait (VT:0010549)percentage of study population developing cerebrovascular lesions during a period of time (CMO:0000932)185219805968120379Rat

Markers in Region
D18Rat13  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21863,636,721 - 63,636,873 (+)MAPPERmRatBN7.2
Rnor_6.01868,524,848 - 68,524,999NCBIRnor6.0
Rnor_5.01867,677,951 - 67,678,102UniSTSRnor5.0
RGSC_v3.41866,720,035 - 66,720,186UniSTSRGSC3.4
Celera1861,728,726 - 61,728,877UniSTS
RH 3.4 Map18658.1UniSTS
RH 3.4 Map18658.1RGD
RH 2.0 Map18253.5RGD
SHRSP x BN Map1838.7899RGD
FHH x ACI Map1844.15RGD
Cytogenetic Map18q12.1UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 161 87 86 55 92 55 6 350 192 11 140 79 90 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000016369   ⟹   ENSRNOP00000016369
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1865,876,342 - 66,067,700 (-)Ensembl
mRatBN7.2 Ensembl1863,600,937 - 63,757,180 (-)Ensembl
Rnor_6.0 Ensembl1868,488,942 - 68,551,558 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000106463   ⟹   ENSRNOP00000095120
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1865,876,342 - 65,938,583 (-)Ensembl
mRatBN7.2 Ensembl1863,600,937 - 63,663,190 (-)Ensembl
RefSeq Acc Id: NM_053459   ⟹   NP_445911
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81865,876,342 - 65,938,583 (-)NCBI
mRatBN7.21863,600,937 - 63,663,190 (-)NCBI
Rnor_6.01868,489,136 - 68,551,310 (-)NCBI
Rnor_5.01867,638,697 - 67,796,869 (-)NCBI
RGSC_v3.41866,682,627 - 66,747,813 (-)RGD
Celera1861,692,971 - 61,755,141 (-)RGD
Sequence:
RefSeq Acc Id: XM_006254930   ⟹   XP_006254992
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81865,870,230 - 66,032,659 (-)NCBI
mRatBN7.21863,597,554 - 63,757,248 (-)NCBI
Rnor_6.01868,486,006 - 68,644,595 (-)NCBI
Rnor_5.01867,638,697 - 67,796,869 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017601046   ⟹   XP_017456535
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81865,870,230 - 65,887,694 (-)NCBI
mRatBN7.21863,597,554 - 63,612,293 (-)NCBI
Rnor_6.01868,486,006 - 68,500,436 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039097193   ⟹   XP_038953121
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81865,870,230 - 66,032,656 (-)NCBI
mRatBN7.21863,597,554 - 63,757,241 (-)NCBI
RefSeq Acc Id: XM_039097194   ⟹   XP_038953122
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81865,870,230 - 66,032,518 (-)NCBI
mRatBN7.21863,597,554 - 63,757,109 (-)NCBI
RefSeq Acc Id: XM_039097195   ⟹   XP_038953123
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81865,870,230 - 66,069,521 (-)NCBI
mRatBN7.21863,597,554 - 63,794,124 (-)NCBI
RefSeq Acc Id: XM_039097199   ⟹   XP_038953127
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81865,939,346 - 66,069,597 (-)NCBI
mRatBN7.21863,663,334 - 63,794,124 (-)NCBI
RefSeq Acc Id: XM_063277635   ⟹   XP_063133705
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81865,870,230 - 66,069,520 (-)NCBI
RefSeq Acc Id: XM_063277636   ⟹   XP_063133706
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81865,870,230 - 66,069,520 (-)NCBI
RefSeq Acc Id: NP_445911   ⟸   NM_053459
- UniProtKB: Q99P74 (UniProtKB/Swiss-Prot),   A6IXZ5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006254992   ⟸   XM_006254930
- Peptide Label: isoform X1
- UniProtKB: Q99P74 (UniProtKB/Swiss-Prot),   A6IXZ5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017456535   ⟸   XM_017601046
- Peptide Label: isoform X2
- UniProtKB: A0A8L2Q7R9 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000016369   ⟸   ENSRNOT00000016369
RefSeq Acc Id: XP_038953123   ⟸   XM_039097195
- Peptide Label: isoform X1
- UniProtKB: Q99P74 (UniProtKB/Swiss-Prot),   A6IXZ5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038953121   ⟸   XM_039097193
- Peptide Label: isoform X1
- UniProtKB: Q99P74 (UniProtKB/Swiss-Prot),   A6IXZ5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038953122   ⟸   XM_039097194
- Peptide Label: isoform X1
- UniProtKB: Q99P74 (UniProtKB/Swiss-Prot),   A6IXZ5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038953127   ⟸   XM_039097199
- Peptide Label: isoform X3
Ensembl Acc Id: ENSRNOP00000095120   ⟸   ENSRNOT00000106463
RefSeq Acc Id: XP_063133706   ⟸   XM_063277636
- Peptide Label: isoform X1
- UniProtKB: Q99P74 (UniProtKB/Swiss-Prot),   A6IXZ5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063133705   ⟸   XM_063277635
- Peptide Label: isoform X1
- UniProtKB: Q99P74 (UniProtKB/Swiss-Prot),   A6IXZ5 (UniProtKB/TrEMBL)

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q99P74-F1-model_v2 AlphaFold Q99P74 1-218 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620114 AgrOrtholog
BioCyc Gene G2FUF-7086 BioCyc
Ensembl Genes ENSRNOG00000012176 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000016369 ENTREZGENE
  ENSRNOT00000106463 ENTREZGENE
  ENSRNOT00000106463.1 UniProtKB/Swiss-Prot
Gene3D-CATH 3.40.50.300 UniProtKB/Swiss-Prot
InterPro P-loop_NTPase UniProtKB/Swiss-Prot
  Rab27a/b UniProtKB/Swiss-Prot
  Small_GTP-bd_dom UniProtKB/Swiss-Prot
  Small_GTPase UniProtKB/Swiss-Prot
  Small_GTPase_Rab UniProtKB/Swiss-Prot
KEGG Report rno:84590 UniProtKB/Swiss-Prot
NCBI Gene 84590 ENTREZGENE
PANTHER LD44762P UniProtKB/Swiss-Prot
Pfam Ras UniProtKB/Swiss-Prot
PhenoGen Rab27b PhenoGen
PRINTS RASTRNSFRMNG UniProtKB/Swiss-Prot
PROSITE RAB UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000012176 RatGTEx
SMART RAB UniProtKB/Swiss-Prot
  RAN UniProtKB/Swiss-Prot
  RAS UniProtKB/Swiss-Prot
  RHO UniProtKB/Swiss-Prot
Superfamily-SCOP SSF52540 UniProtKB/Swiss-Prot
UniProt A0A8L2Q7R9 ENTREZGENE, UniProtKB/TrEMBL
  A6IXZ5 ENTREZGENE, UniProtKB/TrEMBL
  Q99P74 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-03-09 Rab27b  RAB27B, member RAS oncogene family  LOC108348810  uncharacterized LOC108348810  Data merged from RGD:11375697 737654 PROVISIONAL
2016-08-02 LOC108348810  uncharacterized LOC108348810      Symbol and Name status set to provisional 70820 PROVISIONAL
2004-09-10 Rab27b  RAB27B, member RAS oncogene family      Symbol and Name status set to approved 1299863 APPROVED
2002-08-07 Rab27b  RAB27B, member RAS oncogene family      Symbol and Name status set to provisional 70820 PROVISIONAL