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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620114
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Rab27b
Name: RAB27B, member RAS oncogene family
Acc ID: CHEBI:29865
Term: benzo[a]pyrene
Definition: An ortho- and peri-fused polycyclic arene consisting of five fused benzene rings.
Chemical ID: MESH:D001564
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Rab27bdecreases expressionISORab27b (Mus musculus)6480464CTDBenzo(a)pyrene results in decreased expression of RAB27B mRNAPMID:15034205 PMID:21569818
Rab27bdecreases expressionISORAB27B (Homo sapiens)6480464CTDBenzo(a)pyrene results in decreased expression of RAB27B mRNAPMID:20106945
Rab27bincreases expressionISORab27b (Mus musculus)6480464CTDBenzo(a)pyrene results in increased expression of RAB27B mRNAPMID:15034205
Rab27bincreases methylationISORAB27B (Homo sapiens)6480464CTDBenzo(a)pyrene results in increased methylation of RAB27B 5' UTRPMID:27901495
Rab27bmultiple interactionsISORab27b (Mus musculus)6480464CTDAHR protein inhibits the reaction [Benzo(a)pyrene results in increased expression of RAB27B mRNA]; AHR protein promotes the reaction [Benzo(a)pyrene results in decreased expression of RAB27B mRNA]PMID:15034205
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