Nucb1 (nucleobindin 1) - Rat Genome Database

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Gene: Nucb1 (nucleobindin 1) Rattus norvegicus
Analyze
Symbol: Nucb1
Name: nucleobindin 1
RGD ID: 620030
Description: Enables G-protein alpha-subunit binding activity; calcium ion binding activity; and guanyl-nucleotide exchange factor activity. Involved in regulation of protein targeting and small GTPase-mediated signal transduction. Located in Golgi apparatus; cytoplasmic vesicle; and extracellular space. Is extrinsic component of Golgi membrane. Orthologous to human NUCB1 (nucleobindin 1); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil; acrylamide.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: bone 63 kDa calcium-binding protein; CALNUC; Nucb; nucleobindin; nucleobindin-1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81105,104,793 - 105,135,730 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1105,104,793 - 105,135,837 (-)EnsemblGRCr8
mRatBN7.2195,968,325 - 95,999,183 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl195,968,326 - 96,003,220 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1101,353,752 - 101,373,866 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01109,826,428 - 109,846,542 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01103,116,822 - 103,136,934 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01101,480,160 - 101,511,029 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1101,480,145 - 101,500,850 (-)Ensemblrn6Rnor6.0
Rnor_5.01102,559,072 - 102,579,628 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4195,961,163 - 95,981,910 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera190,224,246 - 90,244,279 (-)NCBICelera
RGSC_v3.1196,039,273 - 96,060,021 (-)NCBI
Cytogenetic Map1q22NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
4,4'-sulfonyldiphenol  (ISO)
6-propyl-2-thiouracil  (EXP)
acrolein  (ISO)
acrylamide  (EXP,ISO)
all-trans-retinoic acid  (ISO)
alpha-pinene  (ISO)
ammonium chloride  (EXP)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
beta-naphthoflavone  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
Butylbenzyl phthalate  (ISO)
C60 fullerene  (EXP)
cadmium dichloride  (ISO)
caffeine  (ISO)
chlorpyrifos  (ISO)
cisplatin  (EXP)
clofibrate  (ISO)
cobalt dichloride  (ISO)
dextran sulfate  (ISO)
diallyl trisulfide  (ISO)
dimethylselenide  (ISO)
doxorubicin  (ISO)
elemental selenium  (ISO)
fluoxetine  (EXP)
folic acid  (ISO)
fonofos  (ISO)
FR900359  (ISO)
furan  (EXP)
gold atom  (ISO)
gold(0)  (ISO)
hydroxyl  (ISO)
ivermectin  (ISO)
lead(0)  (ISO)
lovastatin  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
methidathion  (ISO)
nickel sulfate  (ISO)
ozone  (ISO)
parathion  (ISO)
quercetin  (ISO)
resveratrol  (ISO)
rotenone  (EXP)
SB 431542  (ISO)
selenium atom  (ISO)
silicon dioxide  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
T-2 toxin  (EXP)
tamoxifen  (ISO)
terbufos  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (ISO)
titanium dioxide  (ISO)
trichloroethene  (EXP)
triphenyl phosphate  (ISO)
triptonide  (ISO)
tunicamycin  (ISO)
valproic acid  (ISO)
warfarin  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. A systematic analysis of 40 random genes in cultured vascular smooth muscle subtypes reveals a heterogeneity of gene expression and identifies the tight junction gene zonula occludens 2 as a marker of epithelioid "pup" smooth muscle cells and a participant in carotid neointimal formation. Adams LD, etal., Arterioscler Thromb Vasc Biol 1999 Nov;19(11):2600-8.
2. Calnuc binds to LRP9 and affects its endosomal sorting. Brodeur J, etal., Traffic. 2009 Aug;10(8):1098-114. doi: 10.1111/j.1600-0854.2009.00933.x. Epub 2009 May 30.
3. Proteomic analysis of cisplatin-induced cochlear damage: methods and early changes in protein expression. Coling DE, etal., Hear Res. 2007 Apr;226(1-2):140-56. Epub 2007 Jan 24.
4. Nucleobindin-2/nesfatin in the endocrine pancreas: distribution and relationship to glycaemic state. Foo KS, etal., J Endocrinol. 2010 Mar;204(3):255-63. doi: 10.1677/JOE-09-0254. Epub 2009 Dec 23.
5. G Protein binding sites on Calnuc (nucleobindin 1) and NUCB2 (nucleobindin 2) define a new class of G(alpha)i-regulatory motifs. Garcia-Marcos M, etal., J Biol Chem. 2011 Aug 12;286(32):28138-49. doi: 10.1074/jbc.M110.204099. Epub 2011 Jun 8.
6. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
7. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
8. Calnuc, an EF-hand Ca(2+)-binding protein, is stored and processed in the Golgi and secreted by the constitutive-like pathway in AtT20 cells. Lavoie C, etal., Mol Endocrinol. 2002 Nov;16(11):2462-74.
9. The mammalian calcium-binding protein, nucleobindin (CALNUC), is a Golgi resident protein. Lin P, etal., J Cell Biol. 1998 Jun 29;141(7):1515-27.
10. Overexpression of CALNUC (nucleobindin) increases agonist and thapsigargin releasable Ca2+ storage in the Golgi. Lin P, etal., J Cell Biol. 1999 Apr 19;145(2):279-89.
11. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
12. Nucleobindin is produced by bone cells and secreted into the osteoid, with a potential role as a modulator of matrix maturation. Petersson U, etal., Bone. 2004 Jun;34(6):949-60.
13. GOA pipeline RGD automated data pipeline
14. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
15. Isolation, characterization, and primary structure of a calcium-binding 63-kDa bone protein. Wendel M, etal., J Biol Chem 1995 Mar 17;270(11):6125-33.
Additional References at PubMed
PMID:10639138   PMID:12477932   PMID:15308636   PMID:16502470   PMID:16641100   PMID:19199708   PMID:19946888   PMID:20679342   PMID:23533145   PMID:23955309   PMID:25002582   PMID:25736948  
PMID:26666627  


Genomics

Comparative Map Data
Nucb1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81105,104,793 - 105,135,730 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1105,104,793 - 105,135,837 (-)EnsemblGRCr8
mRatBN7.2195,968,325 - 95,999,183 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl195,968,326 - 96,003,220 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1101,353,752 - 101,373,866 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01109,826,428 - 109,846,542 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01103,116,822 - 103,136,934 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01101,480,160 - 101,511,029 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1101,480,145 - 101,500,850 (-)Ensemblrn6Rnor6.0
Rnor_5.01102,559,072 - 102,579,628 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4195,961,163 - 95,981,910 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera190,224,246 - 90,244,279 (-)NCBICelera
RGSC_v3.1196,039,273 - 96,060,021 (-)NCBI
Cytogenetic Map1q22NCBI
NUCB1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381948,900,312 - 48,923,372 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1948,900,050 - 48,923,473 (+)Ensemblhg38GRCh38
GRCh371949,403,569 - 49,426,629 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361954,091,637 - 54,118,340 (+)NCBIBuild 36Build 36hg18NCBI36
Build 341954,095,852 - 54,118,337NCBI
Celera1946,270,663 - 46,293,902 (+)NCBICelera
Cytogenetic Map19q13.33NCBI
HuRef1945,779,769 - 45,802,972 (+)NCBIHuRef
CHM1_11949,405,174 - 49,428,729 (+)NCBICHM1_1
T2T-CHM13v2.01951,895,140 - 51,918,232 (+)NCBIT2T-CHM13v2.0
Nucb1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39745,142,300 - 45,159,813 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl745,139,882 - 45,159,830 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38745,492,674 - 45,510,408 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl745,490,458 - 45,510,406 (-)Ensemblmm10GRCm38
MGSCv37752,748,044 - 52,765,778 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36745,361,150 - 45,378,372 (-)NCBIMGSCv36mm8
Celera740,949,201 - 40,966,928 (-)NCBICelera
Cytogenetic Map7B3NCBI
cM Map729.33NCBI
Nucb1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555591,722,411 - 1,740,596 (-)Ensembl
ChiLan1.0NW_0049555591,723,986 - 1,739,776 (-)NCBIChiLan1.0ChiLan1.0
NUCB1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22055,003,893 - 55,026,955 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11956,930,112 - 56,953,069 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01945,900,098 - 45,923,056 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11954,831,582 - 54,856,711 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1954,832,426 - 54,855,962 (-)EnsemblpanPan2panpan1.1
NUCB1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11107,453,965 - 107,476,458 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1107,454,636 - 107,476,375 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1106,976,497 - 106,999,075 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01107,978,613 - 108,001,223 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1107,978,615 - 108,001,085 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11107,646,057 - 107,668,201 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01107,292,476 - 107,315,053 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01108,128,088 - 108,150,670 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Nucb1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934921,305,942 - 21,327,980 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366642,924,719 - 2,945,178 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049366642,924,186 - 2,946,035 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NUCB1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl654,180,038 - 54,209,930 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1654,186,610 - 54,209,457 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2650,119,224 - 50,141,964 (-)NCBISscrofa10.2Sscrofa10.2susScr3
NUCB1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1642,133,505 - 42,154,461 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366607322,017,037 - 22,040,686 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Nucb1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248325,071,869 - 5,085,623 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046248325,073,022 - 5,085,493 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Nucb1
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v12154,000,942 - 154,021,211 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Nucb1
382 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:148
Count of miRNA genes:100
Interacting mature miRNAs:119
Transcripts:ENSRNOT00000028390
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1582234Gluco18Glucose level QTL 183.40.0003blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)187889942132889942Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)151941022208479811Rat
1358359Sradr1Stress Responsive Adrenal Weight QTL 14.74adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)139728272132889942Rat
1331793Bp200Blood pressure QTL 2003.71601arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1102780511182384005Rat
1578654Bss10Bone structure and strength QTL 104femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)151940904168768703Rat
2300324Fetw1Fetal weight QTL 112.10.005fetal growth trait (VT:0004201)fetal body weight (CMO:0002080)192963855109494029Rat
1554320Bmd1Bone mineral density QTL 112.20.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)1101228864146228864Rat
1331800Scl25Serum cholesterol level QTL 253.013blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)187785026142582336Rat
7421628Bp361Blood pressure QTL 3610.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)183019780128019780Rat
631495Bp96Blood pressure QTL 964.52arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)166404680111404680Rat
70225Bp58Blood pressure QTL 583.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134184556172281316Rat
2298545Neuinf8Neuroinflammation QTL 84.6nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)166009857160501508Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134565911208798288Rat
631519Pia11Pristane induced arthritis QTL 115.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)193903998191260518Rat
1302788Scl19Serum cholesterol QTL 194.60.001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)166400974132889942Rat
1549903Bp267Blood pressure QTL 267arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)184107164115183752Rat
2313083Bmd74Bone mineral density QTL 7440.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)191302413136302413Rat
2313402Anxrr24Anxiety related response QTL 24aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)151511344153680016Rat
724567Tcas6Tongue tumor susceptibility QTL 66.85tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)1102359314153680016Rat
724521Uae1Urinary albumin excretion QTL 13.80.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)199645382182701046Rat
1358902Bw47Body weight QTL 471.67body mass (VT:0001259)body weight (CMO:0000012)199645382221502378Rat
1358192Ept13Estrogen-induced pituitary tumorigenesis QTL 133.4pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)186622262131622262Rat
2300164Bmd44Bone mineral density QTL 445.40.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)166077886111077886Rat
731168Bp154Blood pressure QTL 1543.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1103779152223964440Rat
631205Bp196Blood pressure QTL 19640.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)198879955208479939Rat
738022Anxrr13Anxiety related response QTL 134.60.00039locomotor behavior trait (VT:0001392)measurement of voluntary locomotion into, out of, or within a discrete space in an open field apparatus (CMO:0001514)192683681137683681Rat
10054135Gmadr2Adrenal mass QTL 21.970.0129adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)186993904131993904Rat
152025249Scl82Serum cholesterol level QTL 824.77blood cholesterol amount (VT:0000180)152891222109116986Rat
1331749Hrtrt11Heart rate QTL 112.973heart pumping trait (VT:2000009)heart rate (CMO:0000002)192683681137683681Rat
7411712Strs4Sensitivity to stroke QTL 48.7cerebrum integrity trait (VT:0010549)percentage of study population developing cerebrovascular lesions during a period of time (CMO:0000932)187558587132558587Rat
737977Bp160Blood pressure QTL 1600.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)197582336142582336Rat
2293142Bp314Blood pressure QTL 314arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1101594089146594089Rat
61433Cia2Collagen induced arthritis QTL 25joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1100345976145345976Rat
724529Cm16Cardiac mass QTL 162.7heart mass (VT:0007028)calculated heart weight (CMO:0000073)196717367160111531Rat

Markers in Region
RH127506  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2195,968,419 - 95,968,600 (+)MAPPERmRatBN7.2
Rnor_6.01101,480,255 - 101,480,435NCBIRnor6.0
Rnor_5.01102,559,167 - 102,559,347UniSTSRnor5.0
RGSC_v3.4195,961,257 - 95,961,437UniSTSRGSC3.4
Celera190,224,340 - 90,224,520UniSTS
RH 3.4 Map1909.6UniSTS
Cytogenetic Map1q22UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000028390   ⟹   ENSRNOP00000028390
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1105,104,793 - 105,125,430 (-)Ensembl
mRatBN7.2 Ensembl195,968,327 - 95,988,963 (-)Ensembl
Rnor_6.0 Ensembl1101,480,145 - 101,500,850 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000079633   ⟹   ENSRNOP00000075192
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1105,104,793 - 105,135,837 (-)Ensembl
mRatBN7.2 Ensembl195,968,326 - 96,003,220 (-)Ensembl
RefSeq Acc Id: NM_053463   ⟹   NP_445915
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81105,104,793 - 105,125,430 (-)NCBI
mRatBN7.2195,968,325 - 95,988,962 (-)NCBI
Rnor_6.01101,480,161 - 101,500,284 (-)NCBI
Rnor_5.01102,559,072 - 102,579,628 (-)NCBI
RGSC_v3.4195,961,163 - 95,981,910 (-)RGD
Celera190,224,246 - 90,244,279 (-)RGD
Sequence:
RefSeq Acc Id: XM_006229164   ⟹   XP_006229226
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81105,104,793 - 105,125,395 (-)NCBI
mRatBN7.2195,968,325 - 95,988,958 (-)NCBI
Rnor_6.01101,480,160 - 101,500,731 (-)NCBI
Rnor_5.01102,559,072 - 102,579,628 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017589801   ⟹   XP_017445290
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81105,104,793 - 105,135,725 (-)NCBI
mRatBN7.2195,968,325 - 95,999,183 (-)NCBI
Rnor_6.01101,480,160 - 101,511,029 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017589802   ⟹   XP_017445291
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81105,104,793 - 105,135,730 (-)NCBI
mRatBN7.2195,968,325 - 95,999,182 (-)NCBI
Rnor_6.01101,480,160 - 101,511,029 (-)NCBI
Sequence:
RefSeq Acc Id: NP_445915   ⟸   NM_053463
- Peptide Label: precursor
- UniProtKB: P97623 (UniProtKB/Swiss-Prot),   Q497A4 (UniProtKB/Swiss-Prot),   Q63083 (UniProtKB/Swiss-Prot),   A6JB42 (UniProtKB/TrEMBL),   A0A8L2UKK1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006229226   ⟸   XM_006229164
- Peptide Label: isoform X3
- UniProtKB: A0A8L2UKK1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017445291   ⟸   XM_017589802
- Peptide Label: isoform X2
- UniProtKB: A0A0G2K9Z3 (UniProtKB/TrEMBL),   A0A8L2UKK1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017445290   ⟸   XM_017589801
- Peptide Label: isoform X1
- UniProtKB: A0A8L2UKK1 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000028390   ⟸   ENSRNOT00000028390
Ensembl Acc Id: ENSRNOP00000075192   ⟸   ENSRNOT00000079633
Protein Domains
EF-hand   NUCB1-like N-terminal

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q63083-F1-model_v2 AlphaFold Q63083 1-459 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13690042
Promoter ID:EPDNEW_R567
Type:initiation region
Name:Nucb1_1
Description:nucleobindin 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01101,500,796 - 101,500,856EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620030 AgrOrtholog
BioCyc Gene G2FUF-59679 BioCyc
Ensembl Genes ENSRNOG00000020889 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000028390 ENTREZGENE
  ENSRNOT00000079633 ENTREZGENE
Gene3D-CATH EF-hand UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7930904 IMAGE-MGC_LOAD
InterPro EF-hand-dom_pair UniProtKB/Swiss-Prot
  EF_Hand_1_Ca_BS UniProtKB/Swiss-Prot
  EF_hand_dom UniProtKB/Swiss-Prot
  Nucleobindin UniProtKB/Swiss-Prot
KEGG Report rno:84595 UniProtKB/Swiss-Prot
MGC_CLONE MGC:124586 IMAGE-MGC_LOAD
NCBI Gene 84595 ENTREZGENE
PANTHER PTHR19237 UniProtKB/Swiss-Prot
  PTHR19237:SF21 UniProtKB/Swiss-Prot
Pfam NUCB1_N UniProtKB/Swiss-Prot
PhenoGen Nucb1 PhenoGen
PROSITE EF_HAND_1 UniProtKB/Swiss-Prot
  EF_HAND_2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000020889 RatGTEx
Superfamily-SCOP SSF47473 UniProtKB/Swiss-Prot
UniProt A0A0G2K9Z3 ENTREZGENE, UniProtKB/TrEMBL
  A0A8L2UKK1 ENTREZGENE, UniProtKB/TrEMBL
  A6JB39_RAT UniProtKB/TrEMBL
  A6JB42 ENTREZGENE, UniProtKB/TrEMBL
  A6JB44_RAT UniProtKB/TrEMBL
  NUCB1_RAT UniProtKB/Swiss-Prot
  P97623 ENTREZGENE
  Q497A4 ENTREZGENE
  Q63083 ENTREZGENE
  Q6P6Q3_RAT UniProtKB/TrEMBL
UniProt Secondary P97623 UniProtKB/Swiss-Prot
  Q497A4 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2005-01-20 Nucb1  nucleobindin 1  Nucb  nucleobindin  Symbol and Name updated 1299863 APPROVED
2002-08-07 Nucb  nucleobindin      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in calvaria of bone 633377