Ywhag (tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma) - Rat Genome Database

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Gene: Ywhag (tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma) Rattus norvegicus
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Symbol: Ywhag
Name: tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma
RGD ID: 62002
Description: Enables receptor tyrosine kinase binding activity. Involved in cellular response to insulin stimulus. Located in vesicle. Is active in presynapse. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 56. Orthologous to human YWHAG (tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma); PARTICIPATES IN insulin responsive facilitative sugar transporter mediated glucose transport pathway; interleukin-3 signaling pathway; mTOR signaling pathway; INTERACTS WITH (+)-schisandrin B; 1-naphthyl isothiocyanate; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 14-3-3 protein gamma; 14-3-3 protein gamma-subtype; 14-3-3G; 3-monooxygenase/tryptophan 5-monooxgenase activation protein gamma polypeptide; tryosine 3-monooxgenase/tryptophan 5 monooxgenase activation protein gamma; tryosine 3-monooxgenase/tryptophan 5-monooxgenase activation protein gamma polypeptide; tryosine 3-monooxgenase/tryptophan 5-monooxgenase activation protein, gamma polypeptide; tyrosine 3-monooxgenase/tryptophan 5-monooxgenase activation protein, gamma polypeptide; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide; tyrosine 3/tryptophan 5 -monooxygenase activation protein gamma polypeptide; tyrosine 3/tryptophan 5 -monooxygenase activation protein, gamma polypeptide
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81226,381,106 - 26,409,466 (+)NCBIGRCr8
mRatBN7.21220,744,500 - 20,772,828 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1220,744,535 - 20,772,827 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1221,886,692 - 21,914,903 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01222,499,081 - 22,527,298 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01221,564,574 - 21,592,894 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01223,789,547 - 23,817,884 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1223,789,638 - 23,817,883 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01225,788,140 - 25,816,532 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41221,859,804 - 21,888,050 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11221,847,105 - 21,875,295 (+)NCBI
Celera1222,507,939 - 22,536,185 (+)NCBICelera
RH 3.4 Map12300.5RGD
Cytogenetic Map12q12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model



  
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Original Reference(s)
YwhagRatCOVID-19  ISOYWHAG (Homo sapiens)9068941mRNA:increased expression:peripheral blood mononuclear cell (human)RGDPMID:32228226 and REF_RGD_ID:28912744
YwhagRatCreutzfeldt-Jakob disease  ISOYWHAG (Homo sapiens)127284887protein:increased expression:CSF (human)RGD 
YwhagRatCreutzfeldt-Jakob disease  ISOYWHAG (Homo sapiens)127284881protein:increased expression:CSF (human)RGD 
YwhagRatCreutzfeldt-Jakob disease  ISOYWHAG (Homo sapiens)127284880protein:increased expression:CSF (human)RGD 
YwhagRatSporadic Creutzfeldt-Jakob Disease  ISOYWHAG (Homo sapiens)127284887protein:increased expression:CSF (human)RGD 
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YwhagRatChromosome 7q11.23 Deletion Syndrome, Distal, 1.2-MB  ISOYWHAG (Homo sapiens)8554872ClinVar Annotator: match by term: DISTAL CHROMOSOME 7q11.23 DELETION SYNDROMEClinVar 
YwhagRatConstipation  ISOYWHAG (Homo sapiens)8554872ClinVar Annotator: match by term: ConstipationClinVarPMID:25741868 more ...
YwhagRatdevelopmental and epileptic encephalopathy 56  ISOYWHAG (Homo sapiens)8554872ClinVar more ...ClinVarPMID:23934111 more ...
YwhagRatepilepsy  ISOYWHAG (Homo sapiens)8554872ClinVar more ...ClinVarPMID:25741868 more ...
YwhagRatFailure to Thrive  ISOYWHAG (Homo sapiens)8554872ClinVar Annotator: match by term: Failure to thriveClinVarPMID:25741868 more ...
YwhagRatgenetic disease  ISOYWHAG (Homo sapiens)8554872ClinVar Annotator: match by term: Inborn genetic diseasesClinVarPMID:25741868 more ...
YwhagRatintellectual disability  ISOYWHAG (Homo sapiens)8554872ClinVar Annotator: match by term: intellectual disabilitiesClinVarPMID:25741868 more ...
YwhagRatlearning disability  ISOYWHAG (Homo sapiens)8554872ClinVar Annotator: match by term: Specific learning disabilityClinVar 
YwhagRatmicrocephaly  ISOYWHAG (Homo sapiens)8554872ClinVar Annotator: match by term: MicrocephalyClinVarPMID:25741868 more ...
YwhagRatMuscle Hypotonia  ISOYWHAG (Homo sapiens)8554872ClinVar Annotator: match by term: poor muscle toneClinVarPMID:25741868 more ...
YwhagRatMuscle Spasticity  ISOYWHAG (Homo sapiens)8554872ClinVar Annotator: match by term: SpasticityClinVarPMID:25741868 more ...
YwhagRatpleomorphic xanthoastrocytoma  ISOYWHAG (Homo sapiens)8554872ClinVar Annotator: match by term: Pleomorphic xanthoastrocytomaClinVarPMID:28299358
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YwhagRatExperimental Liver Cirrhosis  ISOYWHAG (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:25380136
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YwhagRatdevelopmental and epileptic encephalopathy 56  ISOYWHAG (Homo sapiens)7240710 OMIM 

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Original Reference(s)
YwhagRat(+)-schisandrin B multiple interactionsEXP 6480464schizandrin B inhibits the reaction [Carbon Tetrachloride results in increased expression of YWHAG mRNA]CTDPMID:31150632
YwhagRat(-)-epigallocatechin 3-gallate multiple interactionsISOYWHAG (Homo sapiens)6480464[potassium chromate(VI) co-treated with epigallocatechin gallate] results in increased expression of YWHAG mRNACTDPMID:22079256
YwhagRat(1->4)-beta-D-glucan multiple interactionsISOYwhag (Mus musculus)6480464[perfluorooctane sulfonic acid co-treated with Cellulose] results in increased expression of YWHAG mRNACTDPMID:36331819
YwhagRat1,2-dimethylhydrazine multiple interactionsISOYwhag (Mus musculus)6480464[1 and 2-Dimethylhydrazine co-treated with Folic Acid] results in decreased expression of YWHAG mRNACTDPMID:22206623
YwhagRat1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine decreases expressionISOYwhag (Mus musculus)64804641-Methyl-4-phenyl-1 more ...CTDPMID:15329391
YwhagRat1-naphthyl isothiocyanate increases expressionEXP 64804641-Naphthylisothiocyanate results in increased expression of YWHAG mRNACTDPMID:25380136
YwhagRat17beta-estradiol affects expressionISOYWHAG (Homo sapiens)6480464Estradiol affects the expression of YWHAG mRNACTDPMID:22574217
YwhagRat17beta-estradiol increases expressionISOYWHAG (Homo sapiens)6480464Estradiol results in increased expression of YWHAG mRNACTDPMID:31614463
YwhagRat2,3,7,8-tetrachlorodibenzodioxine affects expressionISOYwhag (Mus musculus)6480464Tetrachlorodibenzodioxin affects the expression of YWHAG mRNACTDPMID:21570461
YwhagRat2,3,7,8-tetrachlorodibenzodioxine decreases expressionEXP 6480464Tetrachlorodibenzodioxin results in decreased expression of YWHAG mRNACTDPMID:33387578
YwhagRat2,3,7,8-tetrachlorodibenzodioxine increases expressionEXP 6480464Tetrachlorodibenzodioxin results in increased expression of YWHAG mRNACTDPMID:26232522 and PMID:34747641
YwhagRat2,4-dibromophenyl 2,4,5-tribromophenyl ether decreases expressionEXP 64804642 more ...CTDPMID:19954255
YwhagRat2,4-dinitrotoluene affects expressionEXP 64804642 and 4-dinitrotoluene affects the expression of YWHAG mRNACTDPMID:21346803
YwhagRat2,6-dimethoxyphenol multiple interactionsISOYWHAG (Homo sapiens)6480464[Sodium Chloride co-treated with pyrogallol 1 more ...CTDPMID:38598786
YwhagRat2,6-dinitrotoluene affects expressionEXP 64804642 and 6-dinitrotoluene affects the expression of YWHAG mRNACTDPMID:21346803
YwhagRat2-hydroxypropanoic acid increases expressionISOYWHAG (Homo sapiens)6480464Lactic Acid results in increased expression of YWHAG mRNACTDPMID:30851411
YwhagRat3,3',5,5'-tetrabromobisphenol A decreases expressionISOYWHAG (Homo sapiens)6480464tetrabromobisphenol A results in decreased expression of YWHAG proteinCTDPMID:31675489
YwhagRat3,4-methylenedioxymethamphetamine increases expressionISOYwhag (Mus musculus)6480464N-Methyl-3 and 4-methylenedioxyamphetamine results in increased expression of YWHAG mRNACTDPMID:20188158
YwhagRat3-chloropropane-1,2-diol increases expressionEXP 6480464alpha-Chlorohydrin results in increased expression of YWHAG proteinCTDPMID:34915118
YwhagRat4,4'-diaminodiphenylmethane increases expressionEXP 64804644 and 4'-diaminodiphenylmethane results in increased expression of YWHAG mRNACTDPMID:25380136

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Biological Process
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YwhagRatcellular response to glucose starvation involved_inISOYWHAG (Homo sapiens)1624291 PMID:36732624RGDPMID:36732624
YwhagRatcellular response to glucose starvation involved_inIEAUniProtKB:P61981 and ensembl:ENSP000003063301600115GO_REF:0000107EnsemblGO_REF:0000107
YwhagRatcellular response to insulin stimulus  IDA 7247577 RGD 
YwhagRatnegative regulation of TORC1 signaling involved_inISOYWHAG (Homo sapiens)1624291 PMID:36732624RGDPMID:36732624
YwhagRatnegative regulation of TORC1 signaling involved_inIEAUniProtKB:P61981 and ensembl:ENSP000003063301600115GO_REF:0000107EnsemblGO_REF:0000107
YwhagRatpositive regulation of cell-cell adhesion involved_inISSUniProtKB:P619811600115GO_REF:0000024UniProtGO_REF:0000024
YwhagRatpositive regulation of cell-cell adhesion involved_inIEAUniProtKB:P61981 and ensembl:ENSP000003063301600115GO_REF:0000107EnsemblGO_REF:0000107
YwhagRatpositive regulation of cell-cell adhesion involved_inISOYWHAG (Homo sapiens)1624291 PMID:29678907RGDPMID:29678907
YwhagRatpositive regulation of T cell activation involved_inISOYWHAG (Homo sapiens)1624291 PMID:38377992RGDPMID:38377992
YwhagRatpositive regulation of T cell activation involved_inIEAUniProtKB:P61981 and ensembl:ENSP000003063301600115GO_REF:0000107EnsemblGO_REF:0000107
YwhagRatpositive regulation of T cell mediated immune response to tumor cell involved_inISOYWHAG (Homo sapiens)1624291 PMID:38377992RGDPMID:38377992
YwhagRatpositive regulation of T cell mediated immune response to tumor cell involved_inIEAUniProtKB:P61981 and ensembl:ENSP000003063301600115GO_REF:0000107EnsemblGO_REF:0000107
YwhagRatprotein localization involved_inIBAFB:FBgn0004907 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
YwhagRatprotein targeting acts_upstream_of_or_withinISOYwhag (Mus musculus)1624291 PMID:12446771RGDPMID:12446771
YwhagRatregulation of neuron differentiation involved_inISSUniProtKB:P619811600115GO_REF:0000024UniProtGO_REF:0000024
YwhagRatregulation of neuron differentiation involved_inIEAUniProtKB:P61981 and ensembl:ENSP000003063301600115GO_REF:0000107EnsemblGO_REF:0000107
YwhagRatregulation of neuron differentiation involved_inISOYWHAG (Homo sapiens)1624291 PMID:11824616RGDPMID:11824616
YwhagRatregulation of protein localization involved_inISSUniProtKB:P619811600115GO_REF:0000024UniProtGO_REF:0000024
YwhagRatregulation of protein localization involved_inIEAUniProtKB:P61981 and ensembl:ENSP000003063301600115GO_REF:0000107EnsemblGO_REF:0000107
YwhagRatregulation of protein localization involved_inISOYWHAG (Homo sapiens)1624291 PMID:29678907RGDPMID:29678907
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Cellular Component
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YwhagRatcytoplasm located_inISOYwhag (Mus musculus)1624291 PMID:29678907RGDPMID:29678907
YwhagRatcytoplasm located_inIEAUniProtKB-KW:KW-09631600115GO_REF:0000043UniProtGO_REF:0000043
YwhagRatcytoplasm is_active_inIBAFB:FBgn0020238 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
YwhagRatcytoplasm located_inISSUniProtKB:P619821600115GO_REF:0000024UniProtGO_REF:0000024
YwhagRatcytosol located_inIEAUniProtKB:P61981 and ensembl:ENSP000003063301600115GO_REF:0000107EnsemblGO_REF:0000107
YwhagRatcytosol located_inIEAUniProtKB-SubCell:SL-00911600115GO_REF:0000044UniProtGO_REF:0000044
YwhagRatcytosol located_inISOYWHAG (Homo sapiens)1624291 PMID:22532927 and PMID:31906564RGDPMID:22532927 and PMID:31906564
YwhagRatmitochondrial matrix located_inISOYWHAG (Homo sapiens)1624291 PMID:22532927RGDPMID:22532927
YwhagRatmitochondrial matrix located_inIEAUniProtKB-SubCell:SL-01701600115GO_REF:0000044UniProtGO_REF:0000044
YwhagRatmitochondrial matrix located_inIEAUniProtKB:P61981 and ensembl:ENSP000003063301600115GO_REF:0000107EnsemblGO_REF:0000107
YwhagRatmitochondrion located_inIEAUniProtKB-KW:KW-04961600115GO_REF:0000043UniProtGO_REF:0000043
YwhagRatnucleus located_inISOYWHAG (Homo sapiens)1624291 PMID:31906564RGDPMID:31906564
YwhagRatnucleus located_inIEAUniProtKB:P61981 and ensembl:ENSP000003063301600115GO_REF:0000107EnsemblGO_REF:0000107
YwhagRatpresynapse is_active_inIDA 13702169PMID:16982421SynGO 
YwhagRatsynapse is_active_inIEP 13702149PMID:7964746SynGO 
YwhagRatsynapse is_active_inIDA 13702149PMID:7964746SynGO 
YwhagRatvesicle  IDA 7247577 RGD 
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Molecular Function
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YwhagRatactin binding enablesISSUniProtKB:P685101600115GO_REF:0000024UniProtGO_REF:0000024
YwhagRatenzyme regulator activity  TAS 61782 RGD 
YwhagRatidentical protein binding enablesIEAUniProtKB:P61981 and ensembl:ENSP000003063301600115GO_REF:0000107EnsemblGO_REF:0000107
YwhagRatidentical protein binding enablesISOYWHAG (Homo sapiens)1624291UniProtKB:P61981 more ...RGDPMID:17085597 more ...
YwhagRatinsulin-like growth factor receptor binding enablesISSUniProtKB:P619811600115GO_REF:0000024UniProtGO_REF:0000024
YwhagRatinsulin-like growth factor receptor binding enablesIEAUniProtKB:P61981 and ensembl:ENSP000003063301600115GO_REF:0000107EnsemblGO_REF:0000107
YwhagRatinsulin-like growth factor receptor binding enablesISOYWHAG (Homo sapiens)1624291UniProtKB:P08069 and PMID:12482592RGDPMID:12482592
YwhagRatphosphorylation-dependent protein binding enablesISOYWHAG (Homo sapiens)1624291 PMID:36732624 and PMID:38377992RGDPMID:36732624 and PMID:38377992
YwhagRatphosphorylation-dependent protein binding enablesIEAUniProtKB:P61981 and ensembl:ENSP000003063301600115GO_REF:0000107EnsemblGO_REF:0000107
YwhagRatphosphorylation-dependent protein binding enablesISSUniProtKB:P619811600115GO_REF:0000024UniProtGO_REF:0000024
YwhagRatprotein binding  IPITbc1d4 (Rattus norvegicus)7247577 RGD 
YwhagRatprotein binding enablesISOYWHAG (Homo sapiens)1624291UniProtKB:A0JLT2-2 more ...RGDPMID:10559254 more ...
YwhagRatprotein binding enablesIPIUniProtKB:Q5S0078554682PMID:24351927IntAct 
YwhagRatprotein binding enablesISOYwhag (Mus musculus)1624291UniProtKB:Q08460 more ...RGDPMID:19423573 more ...
YwhagRatprotein domain specific binding enablesISOYwhag (Mus musculus)1624291 PMID:12446771RGDPMID:12446771
YwhagRatprotein kinase C binding enablesISSUniProtKB:P619811600115GO_REF:0000024UniProtGO_REF:0000024
YwhagRatprotein kinase C binding enablesIEAUniProtKB:P61981 and ensembl:ENSP000003063301600115GO_REF:0000107EnsemblGO_REF:0000107
YwhagRatprotein kinase C binding enablesIBAPANTHER:PTN002705681 and UniProtKB:P619811600115GO_REF:0000033GO_CentralGO_REF:0000033
YwhagRatprotein kinase C binding enablesISOYWHAG (Homo sapiens)1624291UniProtKB:P04049 and PMID:10433554RGDPMID:10433554
YwhagRatprotein sequestering activity enablesISOYWHAG (Homo sapiens)1624291 PMID:36732624 and PMID:38377992RGDPMID:36732624 and PMID:38377992
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Imported Annotations - KEGG (archival)

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Original Reference(s)
YwhagRatcell cycle pathway, mitotic  IEA 6907045 KEGGrno:04110
YwhagRatneurotrophic factor signaling pathway  IEA 6907045 KEGGrno:04722

Imported Annotations - PID (archival)


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Reference Title
Reference Citation
1. Diagnostic value of surrogate CSF biomarkers for Creutzfeldt-Jakob disease in the era of RT-QuIC. Abu-Rumeileh S, etal., J Neurol. 2019 Dec;266(12):3136-3143. doi: 10.1007/s00415-019-09537-0. Epub 2019 Sep 20.
2. Inhibition of calcium/calmodulin-dependent protein kinase kinase by protein 14-3-3. Davare MA, etal., J Biol Chem. 2004 Dec 10;279(50):52191-9. Epub 2004 Oct 6.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. 14-3-3 Proteins directly regulate Ca(2+)/calmodulin-dependent protein kinase kinase alpha through phosphorylation-dependent multisite binding. Ichimura T, etal., FEBS Lett. 2008 Mar 5;582(5):661-5. doi: 10.1016/j.febslet.2008.01.037. Epub 2008 Jan 31.
5. Cerebrospinal fluid neurofilament light in suspected sporadic Creutzfeldt-Jakob disease. Kanata E, etal., J Clin Neurosci. 2019 Feb;60:124-127. doi: 10.1016/j.jocn.2018.09.031. Epub 2018 Oct 9.
6. AS160 phosphotyrosine-binding domain constructs inhibit insulin-stimulated GLUT4 vesicle fusion with the plasma membrane. Koumanov F, etal., J Biol Chem. 2011 May 13;286(19):16574-82. doi: 10.1074/jbc.M111.226092. Epub 2011 Mar 17.
7. High-density rat radiation hybrid maps containing over 24,000 SSLPs, genes, and ESTs provide a direct link to the rat genome sequence. Kwitek AE, etal., Genome Res. 2004 Apr;14(4):750-7
8. Modulation of inactivation properties of CaV2.2 channels by 14-3-3 proteins. Li Y, etal., Neuron. 2006 Sep 21;51(6):755-71. doi: 10.1016/j.neuron.2006.08.014.
9. Subcellular localisation of 14-3-3 isoforms in rat brain using specific antibodies. Martin H, etal., J Neurochem. 1994 Dec;63(6):2259-65.
10. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
11. Parkinson-related LRRK2 mutation R1441C/G/H impairs PKA phosphorylation of LRRK2 and disrupts its interaction with 14-3-3. Muda K, etal., Proc Natl Acad Sci U S A. 2014 Jan 7;111(1):E34-43. doi: 10.1073/pnas.1312701111. Epub 2013 Dec 18.
12. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
13. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
14. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
15. GOA pipeline RGD automated data pipeline
16. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
17. Neurofilaments in blood and CSF for diagnosis and prediction of onset in Creutzfeldt-Jakob disease. Steinacker P, etal., Sci Rep. 2016 Dec 8;6:38737. doi: 10.1038/srep38737.
18. 14-3-3 gamma associates with muscle specific kinase and regulates synaptic gene transcription at vertebrate neuromuscular synapse. Strochlic L, etal., Proc Natl Acad Sci U S A. 2004 Dec 28;101(52):18189-94. Epub 2004 Dec 16.
19. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
20. Molecular cloning of rat cDNAs for beta and gamma subtypes of 14-3-3 protein and developmental changes in expression of their mRNAs in the nervous system. Watanabe M, etal., Brain Res Mol Brain Res 1993 Jan;17(1-2):135-46.
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PMID:10433554   PMID:11824616   PMID:12446771   PMID:12477932   PMID:12482592   PMID:12650640   PMID:15677482   PMID:16854843   PMID:17085597   PMID:17634366   PMID:19056867   PMID:19199708  
PMID:19946888   PMID:20458337   PMID:20639859   PMID:21423176   PMID:22658674   PMID:22871113   PMID:23432726   PMID:24743739   PMID:26316108   PMID:29476059   PMID:30093406   PMID:30478609  
PMID:32357304   PMID:35352799   PMID:36427097  



Ywhag
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81226,381,106 - 26,409,466 (+)NCBIGRCr8
mRatBN7.21220,744,500 - 20,772,828 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1220,744,535 - 20,772,827 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1221,886,692 - 21,914,903 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01222,499,081 - 22,527,298 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01221,564,574 - 21,592,894 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01223,789,547 - 23,817,884 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1223,789,638 - 23,817,883 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01225,788,140 - 25,816,532 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41221,859,804 - 21,888,050 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11221,847,105 - 21,875,295 (+)NCBI
Celera1222,507,939 - 22,536,185 (+)NCBICelera
RH 3.4 Map12300.5RGD
Cytogenetic Map12q12NCBI
YWHAG
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38776,326,799 - 76,358,991 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl776,326,799 - 76,358,991 (-)EnsemblGRCh38hg38GRCh38
GRCh37775,956,116 - 75,988,308 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36775,794,052 - 75,826,252 (-)NCBINCBI36Build 36hg18NCBI36
Build 34775,600,767 - 75,632,967NCBI
Celera770,824,607 - 70,856,862 (-)NCBICelera
Cytogenetic Map7q11.23NCBI
HuRef771,042,455 - 71,074,829 (-)NCBIHuRef
CHM1_1775,886,202 - 75,918,463 (-)NCBICHM1_1
T2T-CHM13v2.0777,614,271 - 77,646,485 (-)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v2775,289,172 - 75,321,406 (-)NCBI
Ywhag
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm395135,937,233 - 135,963,495 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl5135,937,263 - 135,963,470 (-)EnsemblGRCm39 Ensembl
GRCm385135,908,379 - 135,934,641 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5135,908,409 - 135,934,616 (-)EnsemblGRCm38mm10GRCm38
MGSCv375136,384,249 - 136,410,511 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv365136,193,036 - 136,219,151 (-)NCBIMGSCv36mm8
Celera5132,916,950 - 132,946,032 (-)NCBICelera
Cytogenetic Map5G2NCBI
cM Map575.53NCBI
Ywhag
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545614,939,084 - 14,970,248 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495545614,939,130 - 14,970,248 (-)NCBIChiLan1.0ChiLan1.0
YWHAG
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2693,594,488 - 93,627,035 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan17141,859,428 - 141,891,673 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0767,661,589 - 67,693,814 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1782,773,779 - 82,777,252 (-)NCBIpanpan1.1PanPan1.1panPan2
YWHAG
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.167,504,834 - 7,548,097 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl67,507,608 - 7,532,409 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha69,200,437 - 9,228,221 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.067,325,329 - 7,353,135 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl67,325,457 - 7,353,171 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.167,294,343 - 7,322,128 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.067,257,314 - 7,285,076 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.067,420,808 - 7,448,168 (-)NCBIUU_Cfam_GSD_1.0
Ywhag
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024409344131,940,360 - 131,974,428 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365432,061,794 - 2,096,525 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365432,062,137 - 2,096,207 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
YWHAG
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl39,994,836 - 10,023,289 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.139,994,802 - 10,023,296 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.239,882,655 - 9,911,118 (+)NCBISscrofa10.2Sscrofa10.2susScr3
YWHAG
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12810,462,984 - 10,494,500 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2810,462,859 - 10,494,457 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660705,923,909 - 5,955,125 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ywhag
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474014,959,089 - 14,995,548 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474014,960,105 - 14,995,522 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

.

.
Variants in Ywhag
186 total Variants

Predicted Target Of
Summary Value
Count of predictions:369
Count of miRNA genes:219
Interacting mature miRNAs:260
Transcripts:ENSRNOT00000001954
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 55 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
631560Apr1Acute phase response QTL 16.1orosomucoid 1 amount (VT:0010541)plasma orosomucoid 1 level (CMO:0001467)121914436246669029Rat
61443Btemp2Thermal response to stress QTL 23.30.000094body temperature trait (VT:0005535)core body temperature (CMO:0001036)121502518320794014Rat
8552964Pigfal17Plasma insulin-like growth factor 1 level QTL 173.5blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)12556449546669029Rat
61324Eae5Experimental allergic encephalomyelitis QTL 514nervous system integrity trait (VT:0010566)percentage of study population developing relapsing-remitting experimental autoimmune encephalomyelitis during a period of time (CMO:0001402)121961087046669029Rat
9590147Scort7Serum corticosterone level QTL 713.610.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)12142110980Rat
1549829Scl48Serum cholesterol level QTL 485blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)12960327746669029Rat
61331Eau2Experimental allergic uveoretinitis QTL 20.0005uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)12852542328064601Rat
737822Alc10Alcohol consumption QTL 102.2consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)121961087040218516Rat
2293684Bmd26Bone mineral density QTL 264.40.0002femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)121587265332974238Rat
6893681Bw109Body weight QTL 1092.30.004body mass (VT:0001259)body weight (CMO:0000012)12123297788Rat

1 to 10 of 55 rows
BE098443  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21220,771,063 - 20,771,237 (+)MAPPERmRatBN7.2
Rnor_6.01223,816,120 - 23,816,293NCBIRnor6.0
Rnor_5.01225,814,768 - 25,814,941UniSTSRnor5.0
RGSC_v3.41221,886,286 - 21,886,459UniSTSRGSC3.4
Celera1222,534,421 - 22,534,594UniSTS
RH 3.4 Map12301.7UniSTS
Cytogenetic Map12q12UniSTS
RH142408  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21220,771,298 - 20,771,491 (+)MAPPERmRatBN7.2
Rnor_6.01223,816,355 - 23,816,547NCBIRnor6.0
Rnor_5.01225,815,003 - 25,815,195UniSTSRnor5.0
RGSC_v3.41221,886,521 - 21,886,713UniSTSRGSC3.4
Celera1222,534,656 - 22,534,848UniSTS
RH 3.4 Map12300.5UniSTS
Cytogenetic Map12q12UniSTS
RH137270  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21220,771,291 - 20,771,490 (+)MAPPERmRatBN7.2
Rnor_6.01223,816,348 - 23,816,546NCBIRnor6.0
Rnor_5.01225,814,996 - 25,815,194UniSTSRnor5.0
RGSC_v3.41221,886,514 - 21,886,712UniSTSRGSC3.4
Celera1222,534,649 - 22,534,847UniSTS
RH 3.4 Map12298.6UniSTS
Cytogenetic Map12q12UniSTS
BF417900  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21220,764,953 - 20,765,155 (+)MAPPERmRatBN7.2
Rnor_6.01223,810,010 - 23,810,211NCBIRnor6.0
Rnor_5.01225,808,658 - 25,808,859UniSTSRnor5.0
RGSC_v3.41221,880,176 - 21,880,377UniSTSRGSC3.4
Celera1222,528,311 - 22,528,512UniSTS
RH 3.4 Map12300.61UniSTS
Cytogenetic Map12q12UniSTS
SSC3D06  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21220,772,547 - 20,772,744 (+)MAPPERmRatBN7.2
Rnor_6.01223,817,604 - 23,817,800NCBIRnor6.0
Rnor_5.01225,816,252 - 25,816,448UniSTSRnor5.0
RGSC_v3.41221,887,770 - 21,887,966UniSTSRGSC3.4
Celera1222,535,905 - 22,536,101UniSTS
Cytogenetic Map12q12UniSTS




alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31



Ensembl Acc Id: ENSRNOT00000001954   ⟹   ENSRNOP00000001954
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1220,744,535 - 20,772,827 (+)Ensembl
Rnor_6.0 Ensembl1223,789,638 - 23,817,883 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000084730   ⟹   ENSRNOP00000069671
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1220,744,567 - 20,772,825 (+)Ensembl
Rnor_6.0 Ensembl1223,789,675 - 23,817,865 (+)Ensembl
RefSeq Acc Id: NM_019376   ⟹   NP_062249
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81226,381,219 - 26,409,466 (+)NCBI
mRatBN7.21220,744,580 - 20,772,828 (+)NCBI
Rnor_6.01223,789,638 - 23,817,884 (+)NCBI
Rnor_5.01225,788,140 - 25,816,532 (+)NCBI
RGSC_v3.41221,859,804 - 21,888,050 (+)RGD
Celera1222,507,939 - 22,536,185 (+)RGD
Sequence:
RefSeq Acc Id: XM_006249184   ⟹   XP_006249246
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81226,381,106 - 26,409,466 (+)NCBI
mRatBN7.21220,744,500 - 20,772,828 (+)NCBI
Rnor_6.01223,789,547 - 23,817,884 (+)NCBI
Rnor_5.01225,788,140 - 25,816,532 (+)NCBI
Sequence:
1 to 10 of 10 rows
Protein RefSeqs NP_001423349 (Get FASTA)   NCBI Sequence Viewer  
  NP_062249 (Get FASTA)   NCBI Sequence Viewer  
  XP_006249246 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA13844 (Get FASTA)   NCBI Sequence Viewer  
  AAI27497 (Get FASTA)   NCBI Sequence Viewer  
  BAA04261 (Get FASTA)   NCBI Sequence Viewer  
  EDM13340 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000001954.2
  ENSRNOP00000069671
GenBank Protein P61983 (Get FASTA)   NCBI Sequence Viewer  
1 to 10 of 10 rows
RefSeq Acc Id: NP_062249   ⟸   NM_019376
- UniProtKB: A0JPM0 (UniProtKB/Swiss-Prot),   P61983 (UniProtKB/Swiss-Prot),   A6J0A1 (UniProtKB/TrEMBL),   A0A8L2R1A5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006249246   ⟸   XM_006249184
- Peptide Label: isoform X1
- UniProtKB: A0JPM0 (UniProtKB/Swiss-Prot),   P61983 (UniProtKB/Swiss-Prot),   A6J0A1 (UniProtKB/TrEMBL),   A0A8L2R1A5 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000069671   ⟸   ENSRNOT00000084730
Ensembl Acc Id: ENSRNOP00000001954   ⟸   ENSRNOT00000001954
14-3-3

Name Modeler Protein Id AA Range Protein Structure
AF-P61983-F1-model_v2 AlphaFold P61983 1-247 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13698545
Promoter ID:EPDNEW_R9068
Type:initiation region
Name:Ywhag_1
Description:tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activationprotein, gamma
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01223,789,595 - 23,789,655EPDNEW


1 to 34 of 34 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-19639 BioCyc
Ensembl Genes ENSRNOG00000001436 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000001954.4 UniProtKB/Swiss-Prot
  ENSRNOT00000084730 ENTREZGENE
Gene3D-CATH 1.20.190.20 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:8372306 IMAGE-MGC_LOAD
InterPro 14-3-3 UniProtKB/Swiss-Prot
  14-3-3_CS UniProtKB/Swiss-Prot
  14-3-3_dom_sf UniProtKB/Swiss-Prot
  14-3-3_domain UniProtKB/Swiss-Prot
KEGG Report rno:56010 UniProtKB/Swiss-Prot
MGC_CLONE MGC:156653 IMAGE-MGC_LOAD
NCBI Gene 56010 ENTREZGENE
PANTHER PTHR18860 UniProtKB/Swiss-Prot
Pfam 14-3-3 UniProtKB/Swiss-Prot
PhenoGen Ywhag PhenoGen
PIRSF 14-3-3 UniProtKB/Swiss-Prot
PRINTS 1433ZETA UniProtKB/Swiss-Prot
PROSITE 1433_1 UniProtKB/Swiss-Prot
  1433_2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000001436 RatGTEx
SMART 14_3_3 UniProtKB/Swiss-Prot
Superfamily-SCOP SSF48445 UniProtKB/Swiss-Prot
TIGR TC228360
UniProt 1433G_RAT UniProtKB/Swiss-Prot
  A0A8L2R1A5 ENTREZGENE, UniProtKB/TrEMBL
  A0JPM0 ENTREZGENE
  A6J0A1 ENTREZGENE, UniProtKB/TrEMBL
  P61983 ENTREZGENE
UniProt Secondary A0JPM0 UniProtKB/Swiss-Prot
  O70457 UniProtKB/Swiss-Prot
  P35214 UniProtKB/Swiss-Prot
  Q9UDP2 UniProtKB/Swiss-Prot
  Q9UN99 UniProtKB/Swiss-Prot
1 to 34 of 34 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-12-11 Ywhag  tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma  Ywhag  tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-06-27     Ywhag  tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-30 Ywhag  tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide    tyrosine 3-monooxgenase/tryptophan 5-monooxgenase activation protein, gamma polypeptide   Name updated 1299863 APPROVED
2002-06-10 Ywhag  tyrosine 3-monooxgenase/tryptophan 5-monooxgenase activation protein, gamma polypeptide       Name updated 70584 APPROVED
2002-01-14 Ywhag  tryosine 3-monooxgenase/tryptophan 5-monooxgenase activation protein, gamma polypeptide      correction to spelling of name 68926 APPROVED
2001-10-22 Ywhag  tryosine 3-monooxgenase/tryptophan 5 monooxgenase activation protein, gamma      Name updated 68913 WITHDRAWN
2001-10-22 Ywhag  tryosine 3-monooxgenase/tryptophan 5 monooxgenase activation protein, gamma polypeptide      Name updated 68913 APPROVED
2001-07-23 Ywhag  tryosine 3-monooxgenase/tryptophan 5 monooxgenase activation protein, gamma      Name updated to reflect Human and Mouse nomenclature 67952 APPROVED
2001-07-23 Ywhag  3-monooxgenase/tryptophan 5-monooxgenase activation protein, gamma polypeptide      Name withdrawn 67952 WITHDRAWN

Note Type Note Reference
gene_evolution 14-3-3 family of proteins is highly conserved among both plants and animals 61782
gene_homology protein shares 100% sequence identity with human ywhag 61782