Mpp2 (MAGUK p55 scaffold protein 2) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Gene: Mpp2 (MAGUK p55 scaffold protein 2) Rattus norvegicus
Analyze
Symbol: Mpp2
Name: MAGUK p55 scaffold protein 2
RGD ID: 620014
Description: Enables PDZ domain binding activity. A structural constituent of postsynaptic density. Involved in protein homooligomerization. Located in postsynaptic density. Is active in glutamatergic synapse. Orthologous to human MPP2 (MAGUK p55 scaffold protein 2); INTERACTS WITH 2,2',5,5'-tetrachlorobiphenyl; 6-propyl-2-thiouracil; ammonium chloride.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Dlg2; MAGUK p55 subfamily member 2; membrane palmitoylated protein 2; membrane protein, palmitoylated 2; membrane protein, palmitoylated 2 (MAGUK p55 subfamily member 2)
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81087,511,638 - 87,544,710 (-)NCBIGRCr8
mRatBN7.21087,011,434 - 87,043,883 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1087,011,434 - 87,043,896 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1092,042,631 - 92,073,088 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01091,514,685 - 91,545,060 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01086,907,996 - 86,938,375 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01089,998,284 - 90,030,766 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1089,999,917 - 90,030,639 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01089,787,735 - 89,819,927 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41091,125,953 - 91,156,804 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11091,144,644 - 91,168,093 (-)NCBI
Celera1085,731,908 - 85,761,512 (-)NCBICelera
Cytogenetic Map10q32.1NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. A tripartite protein complex with the potential to couple synaptic vesicle exocytosis to cell adhesion in brain. Butz S, etal., Cell 1998 Sep 18;94(6):773-82.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Protein trafficking and anchoring complexes revealed by proteomic analysis of inward rectifier potassium channel (Kir2.x)-associated proteins. Leonoudakis D, etal., J Biol Chem. 2004 May 21;279(21):22331-46. Epub 2004 Mar 15.
4. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
5. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
6. MPP2 is a postsynaptic MAGUK scaffold protein that links SynCAM1 cell adhesion molecules to core components of the postsynaptic density. Rademacher N, etal., Sci Rep. 2016 Oct 19;6:35283. doi: 10.1038/srep35283.
7. GOA pipeline RGD automated data pipeline
8. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:19665017   PMID:26880549   PMID:35075790  


Genomics

Comparative Map Data
Mpp2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81087,511,638 - 87,544,710 (-)NCBIGRCr8
mRatBN7.21087,011,434 - 87,043,883 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1087,011,434 - 87,043,896 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1092,042,631 - 92,073,088 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01091,514,685 - 91,545,060 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01086,907,996 - 86,938,375 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01089,998,284 - 90,030,766 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1089,999,917 - 90,030,639 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01089,787,735 - 89,819,927 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41091,125,953 - 91,156,804 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11091,144,644 - 91,168,093 (-)NCBI
Celera1085,731,908 - 85,761,512 (-)NCBICelera
Cytogenetic Map10q32.1NCBI
MPP2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381743,875,360 - 43,909,711 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1743,875,357 - 43,909,711 (-)EnsemblGRCh38hg38GRCh38
GRCh371741,952,728 - 41,987,079 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361739,308,253 - 39,340,639 (-)NCBINCBI36Build 36hg18NCBI36
Build 341739,308,252 - 39,340,639NCBI
Celera1738,660,767 - 38,693,150 (-)NCBICelera
Cytogenetic Map17q21.31NCBI
HuRef1737,716,788 - 37,751,379 (-)NCBIHuRef
CHM1_11742,188,320 - 42,222,639 (-)NCBICHM1_1
T2T-CHM13v2.01744,727,944 - 44,762,256 (-)NCBIT2T-CHM13v2.0
Mpp2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3911101,947,841 - 101,979,464 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl11101,947,841 - 101,979,341 (-)EnsemblGRCm39 Ensembl
GRCm3811102,057,015 - 102,088,638 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl11102,057,015 - 102,088,515 (-)EnsemblGRCm38mm10GRCm38
MGSCv3711101,918,331 - 101,949,829 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3611101,873,109 - 101,904,592 (-)NCBIMGSCv36mm8
Celera11113,762,219 - 113,794,313 (-)NCBICelera
Cytogenetic Map11DNCBI
cM Map1165.48NCBI
Mpp2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545117,132,181 - 17,144,521 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495545117,130,265 - 17,144,626 (-)NCBIChiLan1.0ChiLan1.0
MPP2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21920,988,640 - 21,030,648 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11722,942,870 - 22,994,935 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01713,487,459 - 13,519,978 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11713,653,155 - 13,685,751 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1713,651,433 - 13,685,752 (+)Ensemblpanpan1.1panPan2
MPP2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1919,411,796 - 19,440,947 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl919,413,619 - 19,438,909 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha918,801,600 - 18,830,160 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0920,107,180 - 20,135,794 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl920,106,929 - 20,136,184 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1918,960,167 - 18,988,743 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0919,149,762 - 19,171,973 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0919,288,295 - 19,316,904 (+)NCBIUU_Cfam_GSD_1.0
Mpp2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560218,747,927 - 18,773,871 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936541418,499 - 446,676 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936541420,546 - 446,671 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MPP2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1219,239,668 - 19,268,011 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11219,239,557 - 19,268,013 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21219,498,903 - 19,506,627 (-)NCBISscrofa10.2Sscrofa10.2susScr3
MPP2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11662,487,176 - 62,519,874 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1662,487,453 - 62,517,413 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607733,261,366 - 33,294,346 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Mpp2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624795915,814 - 937,982 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624795915,245 - 936,191 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Mpp2
161 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:202
Count of miRNA genes:137
Interacting mature miRNAs:150
Transcripts:ENSRNOT00000055190
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2312662Slep8Serum leptin concentration QTL 80.05blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)1057134272102134272Rat
2312668Scl65Serum cholesterol level QTL 650.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)1057134272102134272Rat
2312672Insul15Insulin level QTL 150.01blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1057134272102134272Rat
2306970Anxrr22Anxiety related response QTL 225.95fear/anxiety-related behavior trait (VT:1000241)number of periods of voluntary immobility (CMO:0001045)106134527698211570Rat
2316949Gluco60Glucose level QTL 603.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1014487011107057807Rat
2317029Aia19Adjuvant induced arthritis QTL 192.98joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)1066978955107211142Rat
2317039Aia6Adjuvant induced arthritis QTL 64.31joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)1066978955107211142Rat
1298069Bp168Blood pressure QTL 1685.5blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)102652195798003205Rat
1298078Stresp5Stress response QTL 52.990.00025blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)1042045676104670812Rat
2317754Glom25Glomerulus QTL 253.5urine protein amount (VT:0005160)urine protein level (CMO:0000591)1082685200107211142Rat
4889948Bss91Bone structure and strength QTL 914tibia area (VT:1000281)tibia midshaft total cross-sectional area (CMO:0001715)108256485692369470Rat
6893336Cm75Cardiac mass QTL 750.10.87heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)106134527699703528Rat
6893357Bw102Body weight QTL 1020.50.36body mass (VT:0001259)body weight (CMO:0000012)1080515287101325465Rat
6893366Bw106Body weight QTL 1060.30.47body mass (VT:0001259)body weight (CMO:0000012)1070199100107211142Rat
631269Cia22Collagen induced arthritis QTL 228.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040035094104060283Rat
631270Cia23Collagen induced arthritis QTL 233.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040035094104060283Rat
631530Tls3T-lymphoma susceptibility QTL 300.0001thymus integrity trait (VT:0010555)percentage of study population developing T-cell lymphomas during a period of time (CMO:0001911)105177461295600334Rat
631537Oia4Oil induced arthritis QTL 4joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)107563188787055282Rat
631542Bp82Blood pressure QTL 826.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)102652195798952741Rat
631547Bp87Blood pressure QTL 874.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)104736947092369470Rat
631555Bp134Blood pressure QTL 1340.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)108051528791230079Rat
9589030Epfw9Epididymal fat weight QTL 919.240.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)104444169989441699Rat
7411614Foco18Food consumption QTL 180.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)104444169989441699Rat
8694173Bw149Body weight QTL 1494.380.001body mass (VT:0001259)body weight gain (CMO:0000420)104444169989441699Rat
1300107Rf18Renal function QTL 183.41urine output (VT:0003620)timed urine volume (CMO:0000260)107877551698279596Rat
1302404Cia27Collagen induced arthritis QTL 272.60.0045joint integrity trait (VT:0010548)experimental arthritis severity measurement (CMO:0001459)1076452683107211142Rat
1354608Cm33Cardiac mass QTL 332.8heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)105480929299809292Rat
1359017Hrtrt21Heart rate QTL 212.4heart pumping trait (VT:2000009)heart rate (CMO:0000002)105177294096772940Rat
1558643Cm44Cardiac mass QTL 444.80.0000368heart mass (VT:0007028)heart wet weight (CMO:0000069)106134527699703528Rat
1549846Scl47Serum cholesterol level QTL 473.6blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)105057470795574707Rat
1554317Bmd4Bone mineral density QTL 49.40.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)101981604299406971Rat
1358188Ept9Estrogen-induced pituitary tumorigenesis QTL 93.9pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)107345313696120911Rat
1358915Stresp7Stress response QTL 73.52blood norepinephrine amount (VT:0005663)plasma norepinephrine level (CMO:0001010)107889965587307728Rat
1549831Bss6Bone structure and strength QTL 64lumbar vertebra strength trait (VT:0010574)vertebra ultimate force (CMO:0001678)1057576521102576521Rat
1579919Bp281Blood pressure QTL 2810.01arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)107437208494965338Rat
1576308Schws1Schwannoma susceptibility QTL 10.0041nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)1040035094102359817Rat
61354Pia10Pristane induced arthritis QTL 100.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
61396Bp9Blood pressure QTL 94.80.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1068420376107211142Rat
61427Cia16Collagen induced arthritis QTL 163.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)10635789696121100Rat
2292438Bp311Blood pressure QTL 311arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1076246085107211142Rat
2292617Ept18Estrogen-induced pituitary tumorigenesis QTL 183.9pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)107345313696120911Rat
631267Cia20Collagen induced arthritis QTL 203.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
631268Cia21Collagen induced arthritis QTL 213.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1014487011104060283Rat
61449Ciaa2CIA Autoantibody QTL 27.1blood autoantibody amount (VT:0003725)calculated serum anti-type 2 collagen antibody titer (CMO:0001279)1063221094107211142Rat
70164Bw21Body weight QTL 214.360.00005body mass (VT:0001259)body weight (CMO:0000012)105379749498952626Rat
70171Cari1Carrageenan-induced inflammation QTL 14.90.0005hypodermis integrity trait (VT:0010550)inflammatory exudate volume (CMO:0001429)1053797385107211142Rat
61325Aia5Adjuvant induced arthritis QTL 50.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
2298548Neuinf7Neuroinflammation QTL 73.4nervous system integrity trait (VT:0010566)spinal cord RT1-B protein level (CMO:0002132)1072224939107211142Rat
2300218Hpcl2Hepatic cholesterol level QTL 2liver cholesterol amount (VT:0010498)liver cholesterol level (CMO:0001597)104502965095600334Rat
2301967Cm73Cardiac mass QTL 734.55heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)101448701189062041Rat
2306792Ean4Experimental allergic neuritis QTL 44nervous system integrity trait (VT:0010566)IFNG-secreting splenocyte count (CMO:0002122)108402232193995963Rat
2306793Ean5Experimental allergic neuritis QTL 54.7nervous system integrity trait (VT:0010566)IFNG-secreting splenocyte count (CMO:0002122)107255241693995749Rat
2313105Bss79Bone structure and strength QTL 791.80.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)1062057807107057807Rat
1642980Bp300Blood pressure QTL 300arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1068383129107211142Rat
1331791Cm31Cardiac mass QTL 313.84606heart mass (VT:0007028)heart wet weight (CMO:0000069)1029299504107211142Rat
1357344Bp249Blood pressure QTL 2490.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)106674365598003205Rat
70193Mcs7Mammary carcinoma susceptibility QTL 72.38mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1072224939107211142Rat
4889492Pancm2Pancreatic morphology QTL 23.2pancreatic beta cell morphology trait (VT:0005217)ratio of insulin-positive cell area to total area of splenic region of pancreas (CMO:0001814)1076748906107211142Rat
2301398Kidm38Kidney mass QTL 380.002kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)108400727295933025Rat
2303589Bw87Body weight QTL 872body mass (VT:0001259)body weight (CMO:0000012)1081285008107211142Rat
10450498Bp384Blood pressure QTL 3840.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1067750049107211142Rat
2300172Bmd57Bone mineral density QTL 579.80.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)1069738412107211142Rat
2303118Mamtr7Mammary tumor resistance QTL 70.003mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)109658275104670812Rat
2293646Bss25Bone structure and strength QTL 2510.960.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)1069738412107211142Rat
2293663Bss33Bone structure and strength QTL 339.340.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)1069738412107211142Rat
70188BpQTLcluster1Blood pressure QTL cluster 14.864arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)14232313287323132Rat
70188BpQTLcluster1Blood pressure QTL cluster 14.864arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)14232313287323132Rat
70188BpQTLcluster1Blood pressure QTL cluster 14.864arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)14232313287323132Rat
70188BpQTLcluster1Blood pressure QTL cluster 14.864arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)14232313287323132Rat
1600367Mcs15Mammary carcinoma susceptibility QTL 154.5mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1085565469103884409Rat
10450495Bp383Blood pressure QTL 3830.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)107624608594965338Rat
61387Bp1Blood pressure QTL 15.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1051770177107211142Rat
61387Bp1Blood pressure QTL 15.1arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1051770177107211142Rat
631535Cm51Cardiac mass QTL 513heart mass (VT:0007028)calculated heart weight (CMO:0000073)105178628291669536Rat
70364Bp72Blood pressure QTL 72arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)105112110096121100Rat
12880055Am11Aortic mass QTL 110.004aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)108400727295933025Rat
2293698Bss43Bone structure and strength QTL 435.330.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra cross-sectional area (CMO:0001689)1059209888104209888Rat
2313103Bss80Bone structure and strength QTL 8020.0001tibia strength trait (VT:1000284)tibia midshaft endosteal cross-sectional area (CMO:0001716)1062057807107057807Rat
724556Pur2Proteinuria QTL 25.5urine protein amount (VT:0005160)urine protein level (CMO:0000591)102242750090627625Rat
70198BpQTLcluster9Blood pressure QTL cluster 92.94arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)104232313287323132Rat

Markers in Region
RH134320  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21087,011,634 - 87,011,838 (+)MAPPERmRatBN7.2
Rnor_6.01089,998,486 - 89,998,689NCBIRnor6.0
Rnor_5.01089,787,937 - 89,788,140UniSTSRnor5.0
RGSC_v3.41091,124,382 - 91,124,588UniSTSRGSC3.4
Celera1085,730,340 - 85,730,543UniSTS
RH 3.4 Map10885.6UniSTS
Cytogenetic Map10q32.1UniSTS
BE112030  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21087,039,575 - 87,039,762 (+)MAPPERmRatBN7.2
Rnor_6.01090,026,416 - 90,026,602NCBIRnor6.0
Rnor_5.01089,815,616 - 89,815,802UniSTSRnor5.0
RGSC_v3.41091,152,796 - 91,152,982UniSTSRGSC3.4
Celera1085,757,501 - 85,757,687UniSTS
RH 3.4 Map10882.8UniSTS
Cytogenetic Map10q32.1UniSTS
RH137648  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21087,012,461 - 87,012,651 (+)MAPPERmRatBN7.2
Rnor_6.01089,999,313 - 89,999,502NCBIRnor6.0
Rnor_5.01089,788,764 - 89,788,953UniSTSRnor5.0
RGSC_v3.41091,125,212 - 91,125,401UniSTSRGSC3.4
Celera1085,731,167 - 85,731,356UniSTS
RH 3.4 Map10887.0UniSTS
Cytogenetic Map10q32.1UniSTS
BE119088  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21087,025,881 - 87,026,036 (+)MAPPERmRatBN7.2
Rnor_6.01090,012,731 - 90,012,885NCBIRnor6.0
Rnor_5.01089,802,233 - 89,802,387UniSTSRnor5.0
RGSC_v3.41091,138,630 - 91,138,784UniSTSRGSC3.4
Celera1085,744,418 - 85,744,572UniSTS
RH 3.4 Map10882.9UniSTS
Cytogenetic Map10q32.1UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 10 4 4 4 72 4 3
Low 3 25 30 20 13 20 2 3 2 31 32 11 2
Below cutoff 8 22 16 6 16 6 8 6 6

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000090456   ⟹   ENSRNOP00000073193
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1087,011,434 - 87,043,896 (-)Ensembl
Rnor_6.0 Ensembl1089,999,917 - 90,030,639 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000092150   ⟹   ENSRNOP00000072422
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1087,011,434 - 87,043,773 (-)Ensembl
Rnor_6.0 Ensembl1090,000,054 - 90,030,423 (-)Ensembl
RefSeq Acc Id: NM_001414214   ⟹   NP_001401143
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81087,511,638 - 87,544,029 (-)NCBI
mRatBN7.21087,011,434 - 87,043,835 (-)NCBI
RefSeq Acc Id: NM_001414222   ⟹   NP_001401151
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81087,511,638 - 87,544,029 (-)NCBI
mRatBN7.21087,011,434 - 87,043,835 (-)NCBI
RefSeq Acc Id: NM_053513   ⟹   NP_445965
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81087,511,638 - 87,544,029 (-)NCBI
mRatBN7.21087,011,434 - 87,043,835 (-)NCBI
Rnor_6.01090,000,054 - 90,030,423 (-)NCBI
Rnor_5.01089,787,735 - 89,819,927 (-)NCBI
RGSC_v3.41091,125,953 - 91,156,804 (-)RGD
Celera1085,731,908 - 85,761,512 (-)RGD
Sequence:
RefSeq Acc Id: XM_008768128   ⟹   XP_008766350
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81087,511,638 - 87,538,557 (-)NCBI
mRatBN7.21087,011,434 - 87,037,591 (-)NCBI
Rnor_6.01089,998,284 - 90,027,381 (-)NCBI
Sequence:
RefSeq Acc Id: XM_063270001   ⟹   XP_063126071
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81087,511,638 - 87,544,710 (-)NCBI
RefSeq Acc Id: XM_063270002   ⟹   XP_063126072
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81087,511,638 - 87,544,648 (-)NCBI
Reference Protein Sequences
RefSeq Acc Id: NP_445965   ⟸   NM_053513
- UniProtKB: G3V8T8 (UniProtKB/Swiss-Prot),   D3ZAA9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008766350   ⟸   XM_008768128
- Peptide Label: isoform X1
- UniProtKB: A0A8L2R7D6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000072422   ⟸   ENSRNOT00000092150
RefSeq Acc Id: ENSRNOP00000073193   ⟸   ENSRNOT00000090456
RefSeq Acc Id: NP_001401143   ⟸   NM_001414214
- UniProtKB: D3ZAA9 (UniProtKB/Swiss-Prot),   G3V8T8 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: NP_001401151   ⟸   NM_001414222
- UniProtKB: D3ZAA9 (UniProtKB/Swiss-Prot),   G3V8T8 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_063126071   ⟸   XM_063270001
- Peptide Label: isoform X2
RefSeq Acc Id: XP_063126072   ⟸   XM_063270002
- Peptide Label: isoform X2
Protein Domains
Guanylate kinase-like   L27   PDZ   SH3

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZAA9-F1-model_v2 AlphaFold D3ZAA9 1-552 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13697780
Promoter ID:EPDNEW_R8296
Type:single initiation site
Name:Mpp2_1
Description:membrane palmitoylated protein 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01090,030,662 - 90,030,722EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620014 AgrOrtholog
BioCyc Gene G2FUF-23130 BioCyc
Ensembl Genes ENSRNOG00000059683 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSRNOG00055033391 UniProtKB/Swiss-Prot
  ENSRNOG00060015166 UniProtKB/Swiss-Prot
  ENSRNOG00065026717 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000090456.2 UniProtKB/TrEMBL
  ENSRNOT00000092150 ENTREZGENE
  ENSRNOT00000092150.2 UniProtKB/Swiss-Prot
  ENSRNOT00055057746 UniProtKB/Swiss-Prot
  ENSRNOT00060026017 UniProtKB/Swiss-Prot
  ENSRNOT00065046111 UniProtKB/Swiss-Prot
Gene3D-CATH 2.30.42.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.40.50.300 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  L27 domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH3 Domains UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro GK/Ca_channel_bsu UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Guanylate_kin-like_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Guanylate_kinase_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  L27_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  L27_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  L27_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MPP2_SH3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  P-loop_NTPase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PDZ UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PDZ_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH3-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH3_domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:85275 UniProtKB/Swiss-Prot
NCBI Gene 85275 ENTREZGENE
PANTHER MAGUK P55 SUBFAMILY MEMBER 2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MEMBRANE-ASSOCIATED GUANYLATE KINASE MAGUK UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Guanylate_kin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  L27 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PDZ UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH3_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Mpp2 PhenoGen
PROSITE GUANYLATE_KINASE_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GUANYLATE_KINASE_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  L27 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PDZ UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000059683 RatGTEx
  ENSRNOG00055033391 RatGTEx
  ENSRNOG00060015166 RatGTEx
  ENSRNOG00065026717 RatGTEx
SMART GuKc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  L27 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PDZ UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF101288 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF50044 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF50156 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF52540 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8L2R7D6 ENTREZGENE, UniProtKB/TrEMBL
  D3ZAA9 ENTREZGENE
  G3V8T8 ENTREZGENE
  MPP2_RAT UniProtKB/Swiss-Prot
UniProt Secondary G3V8T8 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-09-23 Mpp2  MAGUK p55 scaffold protein 2  Mpp2  membrane palmitoylated protein 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2016-04-14 Mpp2  membrane palmitoylated protein 2  Mpp2  membrane protein, palmitoylated 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2015-12-10 Mpp2  membrane protein, palmitoylated 2  Mpp2  membrane protein, palmitoylated 2 (MAGUK p55 subfamily member 2)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-09-10 Mpp2  membrane protein, palmitoylated 2 (MAGUK p55 subfamily member 2)      Symbol and Name status set to approved 1299863 APPROVED
2002-08-07 Mpp2  membrane protein, palmitoylated 2 (MAGUK p55 subfamily member 2)      Symbol and Name status set to provisional 70820 PROVISIONAL