Asl (argininosuccinate lyase) - Rat Genome Database

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Gene: Asl (argininosuccinate lyase) Rattus norvegicus
Analyze
Symbol: Asl
Name: argininosuccinate lyase
RGD ID: 619974
Description: Enables argininosuccinate lyase activity. Involved in several processes, including argininosuccinate metabolic process; cellular response to cAMP; and cellular response to cytokine stimulus. Located in several cellular components, including cell body fiber; mitochondrial outer membrane; and perikaryon. Human ortholog(s) of this gene implicated in amino acid metabolic disorder and argininosuccinic aciduria. Orthologous to human ASL (argininosuccinate lyase); PARTICIPATES IN urea cycle pathway; AGAT deficiency pathway; arginine and proline metabolic pathway; INTERACTS WITH 1-naphthyl isothiocyanate; 17beta-estradiol; 17beta-estradiol 3-benzoate.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: arginosuccinase; ASAL
RGD Orthologs
Human
Mouse
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81232,295,779 - 32,313,257 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1232,295,633 - 32,317,261 (+)EnsemblGRCr8
mRatBN7.21226,659,664 - 26,677,136 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1226,659,565 - 26,679,662 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1227,807,557 - 27,824,901 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01228,418,086 - 28,435,430 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01227,479,553 - 27,496,930 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01230,160,922 - 30,178,348 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1230,165,694 - 30,178,341 (+)Ensemblrn6Rnor6.0
Rnor_5.01232,097,760 - 32,115,110 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41227,702,882 - 27,720,230 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1228,373,639 - 28,390,987 (+)NCBICelera
RGSC_v3.11227,570,168 - 27,583,445 (+)NCBI
Cytogenetic Map12q12NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,1-dichloroethene  (ISO)
1,2-dimethylhydrazine  (ISO)
1-naphthyl isothiocyanate  (EXP)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2,4-dinitrotoluene  (EXP)
2-hydroxypropanoic acid  (ISO)
3,3',4,4'-tetrachlorobiphenyl  (ISO)
3-chloropropane-1,2-diol  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one  (ISO)
acetylsalicylic acid  (ISO)
acrylamide  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
ammonium acetate  (EXP)
ammonium chloride  (EXP)
amphetamine  (EXP)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
atrazine  (EXP)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[b]fluoranthene  (ISO)
beta-lapachone  (ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
bisphenol F  (ISO)
bromobenzene  (EXP)
carbamazepine  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
chloroform  (EXP)
cisplatin  (ISO)
clofibrate  (ISO)
cobalt dichloride  (EXP,ISO)
copper(II) sulfate  (ISO)
crocidolite asbestos  (ISO)
cyclosporin A  (ISO)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
diazinon  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (ISO)
diclofenac  (ISO)
dorsomorphin  (ISO)
elemental selenium  (ISO)
epoxiconazole  (ISO)
fenthion  (ISO)
folic acid  (ISO)
fumonisin B1  (ISO)
furan  (EXP)
gentamycin  (EXP)
glafenine  (EXP)
indometacin  (ISO)
isoniazide  (EXP)
ivermectin  (ISO)
lead diacetate  (EXP)
lipopolysaccharide  (EXP)
lithium atom  (ISO)
lithium hydride  (ISO)
metformin  (EXP)
methamphetamine  (EXP)
methotrexate  (ISO)
N-nitrosomorpholine  (EXP)
nickel dichloride  (EXP)
ochratoxin A  (EXP)
oxycodone  (EXP)
ozone  (EXP)
paracetamol  (EXP,ISO)
parathion  (ISO)
perfluorooctanoic acid  (EXP)
phenformin  (EXP)
phenobarbital  (EXP)
pirinixic acid  (EXP,ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
quercetin  (ISO)
rac-lactic acid  (ISO)
rotenone  (EXP)
sarin  (ISO)
SB 431542  (ISO)
selenium atom  (ISO)
sevoflurane  (EXP)
silibinin  (EXP)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
tetrachloromethane  (EXP,ISO)
tetracycline  (EXP)
theophylline  (EXP)
thioacetamide  (EXP)
Torularhodin  (ISO)
triphenyl phosphate  (EXP,ISO)
Triptolide  (ISO)
valproic acid  (ISO)
vancomycin  (ISO)
zidovudine  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Amino acid sequence of rat argininosuccinate lyase deduced from cDNA. Amaya Y, etal., J Biochem (Tokyo) 1988 Jan;103(1):177-81.
2. Decreased urea synthesis in cafeteria-diet-induced obesity in the rat. Barber T, etal., Biochem J. 1985 Sep 15;230(3):675-81.
3. Transient ischemia increases neuronal nitric oxide synthase, argininosuccinate synthetase and argininosuccinate lyase co-expression in rat striatal neurons. Bizzoco E, etal., Exp Neurol. 2006 Dec 30;.
4. Activated microglia cells express argininosuccinate synthetase and argininosuccinate lyase in the rat brain after transient ischemia. Bizzoco E, etal., Exp Neurol. 2007 Nov;208(1):100-9. Epub 2007 Aug 17.
5. Measurement of nitric oxide-related enzymes in the brain by in situ hybridization. Braissant O Methods Mol Biol. 2004;279:113-24.
6. Hyperammonemia: regulation of argininosuccinate synthetase and argininosuccinate lyase genes in aggregating cell cultures of fetal rat brain. Braissant O, etal., Neurosci Lett. 1999 May 7;266(2):89-92.
7. Significant Down-Regulation of Urea Cycle Generates Clinically Relevant Proteomic Signature in Hepatocellular Carcinoma Patients with Macrovascular Invasion. Cao Y, etal., J Proteome Res. 2019 May 3;18(5):2032-2044. doi: 10.1021/acs.jproteome.8b00921. Epub 2019 Mar 29.
8. Argininosuccinate synthetase and argininosuccinate lyase are localized around mitochondria: an immunocytochemical study. Cohen NS and Kuda A, J Cell Biochem. 1996 Mar 1;60(3):334-40.
9. Arginine-metabolizing enzymes in the developing rat small intestine. De Jonge WJ, etal., Pediatr Res. 1998 Apr;43(4 Pt 1):442-51.
10. Ontogenesis of nitric oxide synthases in the ventilatory muscles. El Dwairi Q, etal., Am J Respir Cell Mol Biol. 1998 Jun;18(6):844-52.
11. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
12. Modulation of intestinal urea cycle by dietary spermine in suckling rat. Gharbi M, etal., Biochem Biophys Res Commun. 2005 Nov 4;336(4):1119-24.
13. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
14. Expression of the genes of arginine-synthesizing enzymes in the rat kidney during development. Goutal I, etal., Biol Neonate. 1999 Oct;76(4):253-60.
15. Effects of growth hormone on steroid-induced increase in ability of urea synthesis and urea enzyme mRNA levels. Grofte T, etal., Am J Physiol. 1998 Jul;275(1 Pt 1):E79-86.
16. Induction of astrocyte argininosuccinate synthetase and argininosuccinate lyase by dibutyryl cyclic AMP and dexamethasone. Jackson MJ, etal., Neurochem Res. 1996 Oct;21(10):1161-5.
17. Structural analysis of an extremely long 5'-noncoding region of rat brain argininosuccinate lyase mRNA: presence of multiple B1 repeats and multiple upstream AUG codons, and a possibility of translational control. Kawamoto S, etal., Biochim Biophys Acta 1993 Apr 29;1173(1):111-4.
18. Molecular cloning and nucleotide sequence of rat brain argininosuccinate lyase cDNA with an extremely long 5'-untranslated sequence: evidence for the identity of the brain and liver enzymes. Kawamoto S, etal., Brain Res Mol Brain Res 1989 May;5(3):235-41.
19. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
20. Clinical, enzymatic, and molecular genetic characterization of a biochemical variant type of argininosuccinic aciduria: prenatal and postnatal diagnosis in five unrelated families. Kleijer WJ, etal., J Inherit Metab Dis 2002 Sep;25(5):399-410.
21. Identification of argininosuccinate lyase as a hypoxia-responsive gene in rat hepatocytes. Latasa MU, etal., J Hepatol. 2000 Nov;33(5):709-15.
22. Structure of the rat argininosuccinate lyase gene: close similarity to chicken delta-crystallin genes. Matsubasa T, etal., Proc Natl Acad Sci U S A 1989 Jan;86(2):592-6.
23. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
24. The 'intestinal-renal' arginine biosynthetic axis in the aging rat. Mistry SK, etal., Mech Ageing Dev. 2002 Apr 30;123(8):1159-65.
25. Nutritional and hormonal regulation of mRNA abundance for arginine biosynthetic enzymes in kidney. Morris SM Jr, etal., Arch Biochem Biophys. 1989 Aug 15;273(1):230-7.
26. Coinduction of nitric oxide synthase, argininosuccinate synthetase, and argininosuccinate lyase in lipopolysaccharide-treated rats. RNA blot, immunoblot, and immunohistochemical analyses. Nagasaki A, etal., J Biol Chem. 1996 Feb 2;271(5):2658-62.
27. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
28. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
29. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
30. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
31. Peripheral genotype-phenotype correlations in Asian Indians with type 2 diabetes mellitus. Rao PV, etal., J Assoc Physicians India. 2005 Jun;53:521-6.
32. Changes in levels of argininosuccinate lyase mRNA during induction by glucagon and cyclic AMP in cultured foetal-rat hepatocytes. Renouf S, etal., Biochem J. 1993 Apr 15;291 ( Pt 2):609-13.
33. Developmental control of argininosuccinate lyase gene by methylation. Renouf S, etal., Biol Neonate. 1998;73(3):190-7.
34. GOA pipeline RGD automated data pipeline
35. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
36. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
37. Journal of animal physiology and animal nutrition Roth VH J Anim Physiol Anim Nutr (Berl). 2001 Feb;85(1-2):45-52.
38. Molecular basis of enzyme abnormalities in urea cycle disorders. With special reference to citrullinemia and argininosuccinic aciduria. Saheki T, etal., Enzyme. 1987;38(1-4):227-32.
39. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
40. Nitric oxide (no), citrulline - no cycle enzymes, glutamine synthetase and oxidative stress in anoxia (hypobaric hypoxia) and reperfusion in rat brain. Swamy M, etal., Int J Med Sci. 2010 May 31;7(3):147-54.
41. Regulation of genes for inducible nitric oxide synthase and urea cycle enzymes in rat liver in endotoxin shock. Tabuchi S, etal., Biochem Biophys Res Commun. 2000 Feb 5;268(1):221-4.
42. Messenger RNA profiles in liver injury and stress: a comparison of lethal and nonlethal rat models. Tygstrup N, etal., Biochem Biophys Res Commun 2002 Jan 11;290(1):518-25.
43. L-Citrulline attenuates arrested alveolar growth and pulmonary hypertension in oxygen-induced lung injury in newborn rats. Vadivel A, etal., Pediatr Res. 2010 Aug 27.
44. L-citrulline recycling by argininosuccinate synthetase and lyase in rat gastric fundus. Van Geldre LA, etal., Eur J Pharmacol. 2002 Nov 29;455(2-3):149-60.
45. Molecular analysis of human argininosuccinate lyase: mutant characterization and alternative splicing of the coding region. Walker DC, etal., Proc Natl Acad Sci U S A 1990 Dec;87(24):9625-9.
46. Urea cycle gene expression is suppressed by PFOA treatment in rats. Walters MW and Wallace KB, Toxicol Lett. 2010 Aug 1;197(1):46-50. Epub 2010 May 7.
47. Preparation of recombinant argininosuccinate synthetase and argininosuccinate lyase: expression of the enzymes in rat tissues. Yu Y, etal., J Biochem (Tokyo). 1995 May;117(5):952-7.
48. Coinduction of inducible nitric oxide synthase and arginine recycling enzymes in cytokine-stimulated PC12 cells and high output production of nitric oxide. Zhang WY, etal., Brain Res Mol Brain Res. 2000 Nov 10;83(1-2):1-8.
Additional References at PubMed
PMID:12559843   PMID:15489334   PMID:19056867   PMID:21988832   PMID:24904080   PMID:25416956   PMID:25502805   PMID:31515488  


Genomics

Comparative Map Data
Asl
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81232,295,779 - 32,313,257 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1232,295,633 - 32,317,261 (+)EnsemblGRCr8
mRatBN7.21226,659,664 - 26,677,136 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1226,659,565 - 26,679,662 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1227,807,557 - 27,824,901 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01228,418,086 - 28,435,430 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01227,479,553 - 27,496,930 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01230,160,922 - 30,178,348 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1230,165,694 - 30,178,341 (+)Ensemblrn6Rnor6.0
Rnor_5.01232,097,760 - 32,115,110 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41227,702,882 - 27,720,230 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1228,373,639 - 28,390,987 (+)NCBICelera
RGSC_v3.11227,570,168 - 27,583,445 (+)NCBI
Cytogenetic Map12q12NCBI
ASL
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38766,075,819 - 66,093,576 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl766,075,800 - 66,094,697 (+)Ensemblhg38GRCh38
GRCh37765,540,806 - 65,558,563 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36765,178,211 - 65,195,765 (+)NCBIBuild 36Build 36hg18NCBI36
Build 34764,984,963 - 65,002,090NCBI
Celera766,555,388 - 66,572,941 (-)NCBICelera
Cytogenetic Map7q11.21ENTREZGENE
HuRef761,727,625 - 61,745,174 (+)NCBIHuRef
CHM1_1765,636,440 - 65,653,994 (+)NCBICHM1_1
T2T-CHM13v2.0767,297,906 - 67,315,665 (+)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v2764,878,281 - 64,895,827 (+)NCBI
Asl
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm395130,040,099 - 130,053,222 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl5130,040,099 - 130,058,088 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm385130,011,258 - 130,024,381 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5130,011,258 - 130,029,247 (-)Ensemblmm10GRCm38
MGSCv375130,487,373 - 130,500,201 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv365130,296,206 - 130,309,034 (-)NCBIMGSCv36mm8
Celera5127,015,654 - 127,028,488 (-)NCBICelera
Cytogenetic Map5G1.3NCBI
cM Map568.37NCBI
Asl
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554568,411,220 - 8,416,992 (-)Ensembl
ChiLan1.0NW_0049554568,409,767 - 8,419,915 (-)NCBIChiLan1.0ChiLan1.0
ASL
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.16768,522 - 779,144 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl6730,358 - 779,424 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha62,468,962 - 2,479,644 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.06573,409 - 584,014 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl6565,544 - 584,326 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.16517,146 - 527,808 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.06511,138 - 521,729 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.06682,422 - 693,029 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Asl
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024409344126,336,725 - 126,347,816 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365437,688,741 - 7,699,851 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365437,688,788 - 7,699,842 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ASL
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl316,637,481 - 16,646,867 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1316,637,481 - 16,646,869 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2316,889,701 - 16,899,549 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ASL
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1281,782,434 - 1,800,581 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl281,782,553 - 1,802,517 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366607014,846,508 - 14,865,029 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Asl
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247408,414,733 - 8,423,777 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247408,414,664 - 8,423,797 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Asl
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11623,963,753 - 23,981,724 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Asl
278 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:63
Count of miRNA genes:60
Interacting mature miRNAs:63
Transcripts:ENSRNOT00000001211
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631560Apr1Acute phase response QTL 16.1orosomucoid 1 amount (VT:0010541)plasma orosomucoid 1 level (CMO:0001467)122480502252308831Rat
70213Niddm27Non-insulin dependent diabetes mellitus QTL 273.72blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)121120049452308831Rat
8552964Pigfal17Plasma insulin-like growth factor 1 level QTL 173.5blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)121120049452308831Rat
8693635Alc28Alcohol consumption QTL 282.70.439drinking behavior trait (VT:0001422)calculated ethanol drink intake rate (CMO:0001615)122871771850386405Rat
7411641Foco19Food consumption QTL 1927.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)121120049452308831Rat
7411643Foco20Food consumption QTL 200.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)122598935552308831Rat
5684888Pia42Pristane induced arthritis QTL 42joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)12348941648489416Rat
1331739Hrtrt14Heart rate QTL 143.56232heart pumping trait (VT:2000009)heart rate (CMO:0000002)12138687564Rat
1641928Alcrsp5Alcohol response QTL 5response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)121847304152308831Rat
8552912Pigfal6Plasma insulin-like growth factor 1 level QTL 65blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)121120049752308831Rat
1549829Scl48Serum cholesterol level QTL 485blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)121526424852308831Rat
61331Eau2Experimental allergic uveoretinitis QTL 20.0005uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)12133700600Rat
10059594Kidm46Kidney mass QTL 463.790.025kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)121174352852308831Rat
8552918Pigfal7Plasma insulin-like growth factor 1 level QTL 7blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)121120049452308831Rat
2293684Bmd26Bone mineral density QTL 264.40.0002femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)12138635130Rat
70169Eae13Experimental allergic encephalomyelitis QTL 130.032nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)122977552242298555Rat
61404Bw120Body weight QTL 1205.1body mass (VT:0001259)body mass index (BMI) (CMO:0000105)121746497946784661Rat
1331786Kidm11Kidney mass QTL 113.571kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)121618743852308831Rat
8693658Alc33Alcohol consumption QTL 332.10.68drinking behavior trait (VT:0001422)calculated ethanol drink intake rate (CMO:0001615)122871771849212240Rat
1331787Rf41Renal function QTL 412.998kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)12133700556Rat
2293699Bss49Bone structure and strength QTL 495.610.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra trabecular cross-sectional area (CMO:0001692)121613502952308831Rat
1331761Bp218Blood pressure QTL 2182.973arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)121618743851213550Rat
1331763Wbc2White blood cell count QTL 23.162leukocyte quantity (VT:0000217)total white blood cell count (CMO:0000365)121120049452308831Rat
61416Pia4Pristane induced arthritis QTL 48.4joint integrity trait (VT:0010548)arthritic paw count (CMO:0001460)121874946936488809Rat
7411547Bw129Body weight QTL 1290.001body mass (VT:0001259)body weight gain (CMO:0000420)61120049452308831Rat
7387292Kidm42Kidney mass QTL 423.030.0004kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)12141361854Rat
61421Cia12Collagen induced arthritis QTL 124.6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)121874946934312613Rat
1300157Rf21Renal function QTL 214.4renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)122963663737764351Rat
1298081Cia25Collagen induced arthritis QTL 254.7joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)12274769447747694Rat
2303569Gluco44Glucose level QTL 442blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)121847304152308831Rat
2303575Insul14Insulin level QTL 144blood insulin amount (VT:0001560)blood insulin level (CMO:0000349)12308718048087180Rat
7411588Foco6Food consumption QTL 60.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)121120049452308831Rat
7243862Mcs30Mammary carcinoma susceptibility QTL 308.62mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)12563330650633306Rat
2300186Bmd59Bone mineral density QTL 597.10.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)121613502952308831Rat
2293086Iddm30Insulin dependent diabetes mellitus QTL 303.82blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)12790162533938215Rat
7411597Foco10Food consumption QTL 100.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)121120049452308831Rat
1331755Bp219Blood pressure QTL 2193.041arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)121618743833700556Rat

Markers in Region
BF388305  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21226,661,399 - 26,661,549 (+)MAPPERmRatBN7.2
Rnor_6.01230,162,607 - 30,162,756NCBIRnor6.0
Rnor_5.01232,099,369 - 32,099,518UniSTSRnor5.0
RGSC_v3.41227,704,491 - 27,704,640UniSTSRGSC3.4
Celera1228,375,248 - 28,375,397UniSTS
RH 3.4 Map12454.3UniSTS
Cytogenetic Map12q13UniSTS
AA818673  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr81232,312,861 - 32,313,155 (+)Marker Load Pipeline
mRatBN7.21226,676,740 - 26,677,034 (+)MAPPERmRatBN7.2
Rnor_6.01230,177,953 - 30,178,246NCBIRnor6.0
Rnor_5.01232,114,715 - 32,115,008UniSTSRnor5.0
RGSC_v3.41227,719,837 - 27,720,130UniSTSRGSC3.4
Celera1228,390,594 - 28,390,887UniSTS
RH 3.4 Map12449.1UniSTS
Cytogenetic Map12q13UniSTS
ASL  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr81232,311,288 - 32,311,752 (+)Marker Load Pipeline
mRatBN7.21226,675,167 - 26,675,631 (+)MAPPERmRatBN7.2
Rnor_6.01230,176,380 - 30,176,843NCBIRnor6.0
Rnor_5.01232,113,142 - 32,113,605UniSTSRnor5.0
RGSC_v3.41227,718,264 - 27,718,727UniSTSRGSC3.4
Celera1228,389,021 - 28,389,484UniSTS
Cytogenetic Map12q13UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 163 91 90 59 92 59 6 356 192 11 142 81 92 31 17 17

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_021577 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006249245 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006249247 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039089715 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063271607 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063271608 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063271609 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC113710 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AH002140 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC078682 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC097270 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473973 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  D13978 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  D28501 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218737 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000012 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000001211   ⟹   ENSRNOP00000001211
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1232,295,633 - 32,313,257 (+)Ensembl
mRatBN7.2 Ensembl1226,667,915 - 26,677,132 (+)Ensembl
Rnor_6.0 Ensembl1230,165,694 - 30,178,341 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000103968   ⟹   ENSRNOP00000095504
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1232,295,873 - 32,317,261 (+)Ensembl
mRatBN7.2 Ensembl1226,659,565 - 26,677,132 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000110317   ⟹   ENSRNOP00000089055
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1232,295,873 - 32,315,828 (+)Ensembl
mRatBN7.2 Ensembl1226,659,565 - 26,679,662 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000132948   ⟹   ENSRNOP00000106091
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1232,295,873 - 32,315,025 (+)Ensembl
RefSeq Acc Id: NM_021577   ⟹   NP_067588
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81232,295,908 - 32,313,255 (+)NCBI
mRatBN7.21226,659,791 - 26,677,134 (+)NCBI
Rnor_6.01230,160,998 - 30,178,346 (+)NCBI
Rnor_5.01232,097,760 - 32,115,110 (+)NCBI
RGSC_v3.41227,702,882 - 27,720,230 (+)RGD
Celera1228,373,639 - 28,390,987 (+)RGD
Sequence:
RefSeq Acc Id: XM_006249245   ⟹   XP_006249307
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81232,295,782 - 32,313,257 (+)NCBI
mRatBN7.21226,659,665 - 26,677,136 (+)NCBI
Rnor_6.01230,160,923 - 30,178,348 (+)NCBI
Rnor_5.01232,097,760 - 32,115,110 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039089715   ⟹   XP_038945643
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81232,296,029 - 32,313,257 (+)NCBI
mRatBN7.21226,660,104 - 26,677,136 (+)NCBI
RefSeq Acc Id: XM_063271607   ⟹   XP_063127677
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81232,295,779 - 32,313,257 (+)NCBI
RefSeq Acc Id: XM_063271608   ⟹   XP_063127678
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81232,295,787 - 32,313,257 (+)NCBI
RefSeq Acc Id: XM_063271609   ⟹   XP_063127679
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81232,296,029 - 32,313,257 (+)NCBI
RefSeq Acc Id: NP_067588   ⟸   NM_021577
- UniProtKB: Q6AZ85 (UniProtKB/Swiss-Prot),   P20673 (UniProtKB/Swiss-Prot),   Q4QRB8 (UniProtKB/TrEMBL),   Z4YND9 (UniProtKB/TrEMBL),   A6J0N5 (UniProtKB/TrEMBL),   A0A8J8XG16 (UniProtKB/TrEMBL),   A0A8I6ARJ8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006249307   ⟸   XM_006249245
- Peptide Label: isoform X1
- UniProtKB: Q6AZ85 (UniProtKB/Swiss-Prot),   P20673 (UniProtKB/Swiss-Prot),   Q4QRB8 (UniProtKB/TrEMBL),   Z4YND9 (UniProtKB/TrEMBL),   A6J0N5 (UniProtKB/TrEMBL),   A0A8J8XG16 (UniProtKB/TrEMBL),   A0A8I6ARJ8 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000001211   ⟸   ENSRNOT00000001211
RefSeq Acc Id: XP_038945643   ⟸   XM_039089715
- Peptide Label: isoform X1
- UniProtKB: Q6AZ85 (UniProtKB/Swiss-Prot),   P20673 (UniProtKB/Swiss-Prot),   Z4YND9 (UniProtKB/TrEMBL),   Q4QRB8 (UniProtKB/TrEMBL),   A6J0N5 (UniProtKB/TrEMBL),   A0A8J8XG16 (UniProtKB/TrEMBL),   A0A8I6ARJ8 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000089055   ⟸   ENSRNOT00000110317
Ensembl Acc Id: ENSRNOP00000095504   ⟸   ENSRNOT00000103968
RefSeq Acc Id: XP_063127677   ⟸   XM_063271607
- Peptide Label: isoform X1
- UniProtKB: Q6AZ85 (UniProtKB/Swiss-Prot),   P20673 (UniProtKB/Swiss-Prot),   A0A8I6ARJ8 (UniProtKB/TrEMBL),   A6J0N5 (UniProtKB/TrEMBL),   Q4QRB8 (UniProtKB/TrEMBL),   Z4YND9 (UniProtKB/TrEMBL),   A0A8J8XG16 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063127678   ⟸   XM_063271608
- Peptide Label: isoform X1
- UniProtKB: Q6AZ85 (UniProtKB/Swiss-Prot),   P20673 (UniProtKB/Swiss-Prot),   A0A8I6ARJ8 (UniProtKB/TrEMBL),   A6J0N5 (UniProtKB/TrEMBL),   Q4QRB8 (UniProtKB/TrEMBL),   Z4YND9 (UniProtKB/TrEMBL),   A0A8J8XG16 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063127679   ⟸   XM_063271609
- Peptide Label: isoform X1
- UniProtKB: Q6AZ85 (UniProtKB/Swiss-Prot),   P20673 (UniProtKB/Swiss-Prot),   A0A8I6ARJ8 (UniProtKB/TrEMBL),   A6J0N5 (UniProtKB/TrEMBL),   Q4QRB8 (UniProtKB/TrEMBL),   Z4YND9 (UniProtKB/TrEMBL),   A0A8J8XG16 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000106091   ⟸   ENSRNOT00000132948
Protein Domains
Argininosuccinate lyase C-terminal   Fumarate lyase N-terminal

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P20673-F1-model_v2 AlphaFold P20673 1-461 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13698579
Promoter ID:EPDNEW_R9104
Type:multiple initiation site
Name:Asl_1
Description:argininosuccinate lyase
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01230,165,757 - 30,165,817EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:619974 AgrOrtholog
BioCyc Gene G2FUF-19522 BioCyc
BioCyc Pathway PWY-4983 [nitric oxide biosynthesis II (mammals)] BioCyc
  PWY-4984 [urea cycle] BioCyc
BioCyc Pathway Image PWY-4983 BioCyc
  PWY-4984 BioCyc
Ensembl Genes ENSRNOG00000000903 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000001211 ENTREZGENE
  ENSRNOT00000110317 ENTREZGENE
Gene3D-CATH 1.10.275.10 UniProtKB/Swiss-Prot
  Fumarase/aspartase (C-terminal domain) UniProtKB/Swiss-Prot
  Fumarase/aspartase (Central domain) UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7109106 IMAGE-MGC_LOAD
  IMAGE:7455735 IMAGE-MGC_LOAD
InterPro Arg_succ_lyase_C UniProtKB/Swiss-Prot
  Argininosuccinate_lyase UniProtKB/Swiss-Prot
  Fumarase/histidase_N UniProtKB/Swiss-Prot
  Fumarate_lyase_CS UniProtKB/Swiss-Prot
  Fumarate_lyase_fam UniProtKB/Swiss-Prot
  Fumarate_lyase_N UniProtKB/Swiss-Prot
  L-Aspartase-like UniProtKB/Swiss-Prot
KEGG Report rno:59085 UniProtKB/Swiss-Prot
MGC_CLONE MGC:114244 IMAGE-MGC_LOAD
  MGC:93044 IMAGE-MGC_LOAD
NCBI Gene 59085 ENTREZGENE
PANTHER ARGININOSUCCINATE LYASE UniProtKB/Swiss-Prot
  PTHR43814 UniProtKB/Swiss-Prot
Pfam ASL_C2 UniProtKB/Swiss-Prot
  Lyase_1 UniProtKB/Swiss-Prot
PhenoGen Asl PhenoGen
PRINTS ARGSUCLYASE UniProtKB/Swiss-Prot
  FUMRATELYASE UniProtKB/Swiss-Prot
PROSITE FUMARATE_LYASES UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000000903 RatGTEx
Superfamily-SCOP SSF48557 UniProtKB/Swiss-Prot
UniProt A0A8I6AB44_RAT UniProtKB/TrEMBL
  A0A8I6ARJ8 ENTREZGENE, UniProtKB/TrEMBL
  A0A8J8XG16 ENTREZGENE, UniProtKB/TrEMBL
  A0ABK0LWH7_RAT UniProtKB/TrEMBL
  A0ABZ3NND4_RAT UniProtKB/TrEMBL
  A6J0N5 ENTREZGENE, UniProtKB/TrEMBL
  ARLY_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q4QRB8 ENTREZGENE
  Q6AZ85 ENTREZGENE
  Z4YND9 ENTREZGENE
UniProt Secondary Q6AZ85 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-09-10 Asl  argininosuccinate lyase      Symbol and Name status set to approved 1299863 APPROVED
2002-08-07 Asl  argininosuccinate lyase      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_expression may be induced in high levels after some types of lethal liver damage 70249