Gcsh Rat Gene (glycine cleavage system protein H (aminomethyl carrier))

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Keyword

Gene:
Gcsh ( Rattus norvegicus )
glycine cleavage system protein H (aminomethyl carrier)
Description: component of the mitochondrial multienzyme glycine cleavage system (GCS); deficiency of the GCS in human causes nonketotic hyperglycinemia (NKH), an inborn error of glycine metabolism
Synonyms: MGC108603;  (details...)
ArrayIDs: GE1243107; 6051023; 5704132; rc_AI103550_at; 1367908_at; 6658382; 6276489; 6468988; 6103011; 6196372; rc_AI172253_s_at; 5987114; 6575336; A_44_P262401; 6671357; 5735808; 6196118; 6424232;  (details...)
Gene Type: protein-coding

Additional Data

Homologs

Comparative Map Data
Species Symbol Map Name Chr. Position
Rattus norvegicus Gcsh Rat Celera Assembly 19 44309206 - 44319921
RGSC genome assembly v3.4 19 47091234 - 47101950
Cytogenetic 19 q12
genome assembly 3.1 19 47096114 - 47106831

View comparative maps:      NCBI MapViewer

Genome
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Annotation
Molecular Function

Note Reference

aminomethyl carrier 70249

Gene Ontology

aminomethyltransferase activity,  lipoic acid binding (details...)
Biological Process

Gene Ontology

glycine decarboxylation via glycine cleavage system (details...)
Cellular Component

Gene Ontology

mitochondrion,  glycine cleavage complex (details...)
Disease

Note Reference

may play a role in the forebrain and cerebellum neuropathogenesis of nonketotic hyperglycinemia (NKH) 708332

Ontology

Hyperglycinemia, Nonketotic (details...)
Expression

Note Reference

may be induced after certain types of damages to liver 70249

Protein

Note Reference

170 amino acids 708332

External Links
Databases
DATABASE ID SOURCE
PROSITE: LIPOYL IPI
UNIPARC: UPI00000E822F IPI
UNIPARC: UPI000019BCC4 IPI
KEGG Report: rno:171133 ENTREZGENE
HomoloGene Group ID: 90880 ENTREZGENE
Germonline: 619946
Pfam: GCV_H IPI
InterPro: Single_hybrid_motif. IPI
InterPro: GCV_H_sub. IPI
InterPro: 2-oxoA_DH_lipoyl-BS. IPI
InterPro: GCV_H. IPI
IPI: IPI00214454 IPI
IPI: IPI00831721 IPI
Ensembl Protein: ENSRNOP00000061677 IPI
Ensembl Protein: ENSRNOP00000015967 IPI
Entrez Gene: Gcsh ENTREZGENE
IMAGE_CLONE: IMAGE:7321648 IMAGE-MGC_LOAD
MGC_CLONE: MGC:108603 IMAGE-MGC_LOAD
UniProt: Q9QYU8_RAT IPI
UniProt: GCSH_RAT IPI
Ensembl Genes: ENSRNOG00000011535 IPI
Superfamily-SCOP: Hybrid_motif IPI
PANTHER: GCV_H IPI
TIGRFAMs: gcvH IPI
Sequences
Nucleotide: BC088114 Get FASTA Search GEO Profiles
Nucleotide: CH473972 Get FASTA Search GEO Profiles
Nucleotide: NM_133598 Get FASTA Search GEO Profiles
Nucleotide: CB609750 Get FASTA Search GEO Profiles
Nucleotide: Y17321 Get FASTA Search GEO Profiles
(View all 5 Nucleotide Accessions)
Protein: Q5I0P2 Get FASTA
Protein: EDL92643 Get FASTA
Protein: NP_598282 Get FASTA
Protein: AAH88114 Get FASTA
Protein: Q9QYU8 Get FASTA
Protein: CAB56621 Get FASTA
(View all 6 Protein Accessions)
Clusters
UniGene: 98456

References
Curated References
6 references in RGD related to Gcsh

Other References
5 other references at PubMed related to Gcsh

Database Information
RGD ID 619946
History

Date Current Symbol Current Name Previous Symbol Previous name Status Description Reference

10-SEP-04: Gcsh glycine cleavage system protein H (aminomethyl carrier) APPROVED Symbol and Name status set to approved 1299863

07-AUG-02: Gcsh glycine cleavage system protein H (aminomethyl carrier) PROVISIONAL Symbol and Name status set to provisional 70820