Vcan (versican) - Rat Genome Database

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Gene: Vcan (versican) Rattus norvegicus
Analyze
Symbol: Vcan
Name: versican
RGD ID: 619940
Description: Predicted to enable protein phosphatase binding activity and protein tyrosine phosphatase activator activity. Involved in axon regeneration. Located in cell surface and perineuronal net. Is active in synapse. Biomarker of myocardial infarction. Human ortholog(s) of this gene implicated in intracranial aneurysm. Orthologous to human VCAN (versican); INTERACTS WITH 1-naphthyl isothiocyanate; 17beta-estradiol; 17beta-estradiol 3-benzoate.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: chondroitin sulfate proteoglycan 2; chondroitin sulfate proteoglycan 2 (versican); chondroitin sulfate proteoglycan core protein 2; Cspg2; GHAP; glial hyaluronate-binding protein; large fibroblast proteoglycan; PG-M; versican core protein
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8222,497,035 - 22,595,955 (-)NCBIGRCr8
mRatBN7.2220,761,718 - 20,860,637 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl220,761,718 - 20,860,637 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx227,798,986 - 27,898,522 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0225,899,274 - 25,998,816 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0220,683,909 - 20,782,542 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0218,490,102 - 18,587,340 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl218,490,102 - 18,565,842 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0218,363,890 - 18,463,115 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4219,712,629 - 19,801,443 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1219,634,740 - 19,688,742 (-)NCBI
Celera216,903,548 - 17,002,158 (-)NCBICelera
Cytogenetic Map2q12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model



  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
VcanRatarteriosclerosis  TAS 632588 RGD 
VcanRatHyaloideoretinal Degeneration of Wagner  ISOVCAN (Homo sapiens)1598496DNA:SNPs:intron:c.4004-5T>C more ...RGD 
VcanRatintracranial aneurysm  ISOVCAN (Homo sapiens)1598495DNA:SNP: :rs173686 (human)RGD 
VcanRatmyocardial infarction  IEP 1598497 RGD 
VcanRatMyocardial Reperfusion Injury  IEP 1598497mRNA:increased expression:heartRGD 
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
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Original Reference(s)
VcanRatfundus dystrophy  ISOVCAN (Homo sapiens)8554872ClinVar Annotator: match by term: Retinal dystrophyClinVarPMID:16043844 more ...
VcanRatgenetic disease  ISOVCAN (Homo sapiens)8554872ClinVar Annotator: match by term: Inborn genetic diseasesClinVarPMID:16043844 more ...
VcanRatHyaloideoretinal Degeneration of Wagner  ISOVCAN (Homo sapiens)8554872ClinVar more ...ClinVarPMID:10333105 more ...
VcanRatNeurodevelopmental Disorders  ISOVCAN (Homo sapiens)8554872ClinVar Annotator: match by term: Neurodevelopmental disorderClinVarPMID:25741868
VcanRatprostate cancer  ISOVCAN (Homo sapiens)8554872ClinVar Annotator: match by term: Malignant tumor of prostateClinVarPMID:23265383 and PMID:28492532
VcanRatStickler syndrome  ISOVCAN (Homo sapiens)8554872ClinVar Annotator: match by term: Stickler syndromeClinVarPMID:16877430 and PMID:25741868
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
VcanRatadenoid cystic carcinoma  ISOVCAN (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:16762588
VcanRatbasal cell carcinoma  ISOVCAN (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:36428691
VcanRatendometriosis  ISOVCAN (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:21063030
VcanRatHyaloideoretinal Degeneration of Wagner  ISOVCAN (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTD 
VcanRatSalivary Gland Neoplasms  ISOVCAN (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:16762588
Object Symbol
Species
Term
Qualifier
Evidence
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Reference
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Original Reference(s)
VcanRatHyaloideoretinal Degeneration of Wagner  ISOVCAN (Homo sapiens)7240710 OMIM 

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Object Symbol
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Reference
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Original Reference(s)
VcanRat(S)-nicotine increases expressionISOVCAN (Homo sapiens)6480464Nicotine results in increased expression of VCAN mRNACTDPMID:23825647
VcanRat1-naphthyl isothiocyanate increases expressionEXP 64804641-Naphthylisothiocyanate results in increased expression of VCAN mRNACTDPMID:30723492
VcanRat1-nitropyrene increases expressionISOVCAN (Homo sapiens)64804641-nitropyrene results in increased expression of VCAN mRNACTDPMID:19041380
VcanRat17beta-estradiol increases expressionISOVcan (Mus musculus)6480464Estradiol results in increased expression of VCAN mRNACTDPMID:19484750 and PMID:30077407
VcanRat17beta-estradiol multiple interactionsEXP 6480464[estradiol 3-benzoate co-treated with [Testosterone co-treated with Estradiol]] results in increased expression of VCAN mRNACTDPMID:32741896
VcanRat17beta-estradiol multiple interactionsISOVcan (Mus musculus)6480464[Polyphenols co-treated with Estradiol] results in increased expression of VCAN mRNACTDPMID:30077407
VcanRat17beta-estradiol multiple interactionsISOVCAN (Homo sapiens)6480464[Estradiol co-treated with Progesterone] results in decreased expression of VCAN mRNA and [Estradiol co-treated with TGFB1 protein] results in increased expression of VCAN mRNACTDPMID:20660070 and PMID:30165855
VcanRat17beta-estradiol 3-benzoate multiple interactionsEXP 6480464[estradiol 3-benzoate co-treated with [Testosterone co-treated with Estradiol]] results in increased expression of VCAN mRNACTDPMID:32741896
VcanRat2,2',4,4'-Tetrabromodiphenyl ether increases expressionISOVCAN (Homo sapiens)64804642 more ...CTDPMID:31675489
VcanRat2,3,7,8-tetrachlorodibenzodioxine increases expressionISOVCAN (Homo sapiens)6480464Tetrachlorodibenzodioxin results in increased expression of VCAN mRNACTDPMID:21998131
VcanRat2,3,7,8-tetrachlorodibenzodioxine affects expressionISOVCAN (Homo sapiens)6480464Tetrachlorodibenzodioxin affects the expression of VCAN mRNACTDPMID:36370075
VcanRat2,3,7,8-tetrachlorodibenzodioxine affects expressionEXP 6480464Tetrachlorodibenzodioxin affects the expression of VCAN mRNACTDPMID:34747641
VcanRat2,3,7,8-tetrachlorodibenzodioxine decreases expressionEXP 6480464Tetrachlorodibenzodioxin results in decreased expression of VCAN mRNACTDPMID:32109520 and PMID:33387578
VcanRat2,3,7,8-tetrachlorodibenzodioxine increases expressionISOVcan (Mus musculus)6480464Tetrachlorodibenzodioxin results in increased expression of VCAN mRNACTDPMID:27562557
VcanRat2,3,7,8-tetrachlorodibenzodioxine affects expressionISOVcan (Mus musculus)6480464Tetrachlorodibenzodioxin affects the expression of VCAN mRNACTDPMID:18691609 and PMID:26377647
VcanRat2,3,7,8-tetrachlorodibenzodioxine increases expressionEXP 6480464Tetrachlorodibenzodioxin results in increased expression of VCAN mRNACTDPMID:22808131
VcanRat2,3,7,8-tetrachlorodibenzodioxine decreases expressionISOVCAN (Homo sapiens)6480464Tetrachlorodibenzodioxin results in decreased expression of VCAN mRNACTDPMID:20106945 and PMID:21632981
VcanRat2,4,6-tribromophenol increases expressionISOVCAN (Homo sapiens)64804642 more ...CTDPMID:31675489
VcanRat2,4,6-trinitrobenzenesulfonic acid multiple interactionsISOVcan (Mus musculus)6480464Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of VCAN mRNA]CTDPMID:18200517
VcanRat2,4,6-trinitrobenzenesulfonic acid increases expressionISOVcan (Mus musculus)6480464Trinitrobenzenesulfonic Acid results in increased expression of VCAN mRNACTDPMID:18200517

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Biological Process

  
Object Symbol
Species
Term
Qualifier
Evidence
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Reference
Notes
Source
Original Reference(s)
VcanRataxon regeneration  IEP 632591 RGD 
VcanRatcell adhesion involved_inIEAInterPro:IPR0005381600115GO_REF:0000002InterProGO_REF:0000002
VcanRatcentral nervous system development involved_inIBAMGI:1096385 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
VcanRatglial cell migration involved_inISOVCAN (Homo sapiens) more ...1624291 PMID:18431253RGDPMID:18431253
VcanRatheart development acts_upstream_of_or_withinISOVcan (Mus musculus)1624291MGI:1857689 PMID:9758703RGDPMID:9758703
VcanRatskeletal system development involved_inIBAMGI:99602 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
VcanRatureteric bud development involved_inISOVcan (Mus musculus)1624291 PMID:16545622RGDPMID:16545622

Cellular Component
1 to 19 of 19 rows

  
Object Symbol
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Source
Original Reference(s)
VcanRatcell periphery located_inIEAARBA:ARBA000274431600115GO_REF:0000117UniProtGO_REF:0000117
VcanRatcell projection located_inIEAUniProtKB-KW:KW-09661600115GO_REF:0000043UniProtGO_REF:0000043
VcanRatcell surface  IDA 1299255 RGD 
VcanRatcollagen-containing extracellular matrix  IDA 1299255 RGD 
VcanRatextracellular matrix located_inIEAARBA:ARBA000273961600115GO_REF:0000117UniProtGO_REF:0000117
VcanRatextracellular matrix located_inISOVcan (Mus musculus)1624291 PMID:14620382RGDPMID:14620382
VcanRatextracellular region located_inIEAUniProtKB-KW:KW-09641600115GO_REF:0000043UniProtGO_REF:0000043
VcanRatextracellular region located_inISSUniProtKB:P136111600115GO_REF:0000024UniProtGO_REF:0000024
VcanRatextracellular region located_inISOVCAN (Homo sapiens)1624291 PMID:25122765RGDPMID:25122765
VcanRatextracellular region located_inIEAUniProtKB-SubCell:SL-02431600115GO_REF:0000044UniProtGO_REF:0000044
VcanRatextracellular region located_inIEAUniProtKB:P13611 and ensembl:ENSP000002650771600115GO_REF:0000107EnsemblGO_REF:0000107
VcanRatextracellular space is_active_inIBAPANTHER:PTN008374273 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
VcanRatinterphotoreceptor matrix located_inIEAUniProtKB-SubCell:SL-01461600115GO_REF:0000044UniProtGO_REF:0000044
VcanRatperineuronal net  IDA 9589827MMO:0000669 and MMO:0000662RGD 
VcanRatperineuronal net is_active_inIBAMGI:1096385 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
VcanRatphotoreceptor outer segment located_inIEAUniProtKB-SubCell:SL-04581600115GO_REF:0000044UniProtGO_REF:0000044
VcanRatsynapse is_active_inEXP 13702274PMID:16507876SynGO 
VcanRatsynapse is_active_inIBAMGI:104694 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
VcanRatsynapse is_active_inIDA 13702274PMID:16507876SynGO 
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Molecular Function
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Reference Title
Reference Citation
1. Versican is upregulated in CNS injury and is a product of oligodendrocyte lineage cells. Asher RA, etal., J Neurosci 2002 Mar 15;22(6):2225-36.
2. Relative and absolute quantification of postsynaptic density proteome isolated from rat forebrain and cerebellum. Cheng D, etal., Mol Cell Proteomics. 2006 Jun;5(6):1158-70. doi: 10.1074/mcp.D500009-MCP200. Epub 2006 Feb 28.
3. Composition of perineuronal net extracellular matrix in rat brain: a different disaccharide composition for the net-associated proteoglycans. Deepa SS, etal., J Biol Chem. 2006 Jun 30;281(26):17789-800. Epub 2006 Apr 27.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
6. Expression of a chondroitin sulfate proteoglycan, versican (PG-M), during development of rat cornea. Koga T, etal., Curr Eye Res. 2005 Jun;30(6):455-63.
7. Versican/PG-M isoforms in vascular smooth muscle cells. Lemire JM, etal., Arterioscler Thromb Vasc Biol 1999 Jul;19(7):1630-9.
8. Overexpression of the V3 variant of versican alters arterial smooth muscle cell adhesion, migration, and proliferation in vitro. Lemire JM, etal., J Cell Physiol 2002 Jan;190(1):38-45.
9. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
10. Differential regulation of expression of hyaluronan-binding proteoglycans in developing brain: aggrecan, versican, neurocan, and brevican. Milev P, etal., Biochem Biophys Res Commun 1998 Jun 18;247(2):207-12.
11. Erosive vitreoretinopathy and wagner disease are caused by intronic mutations in CSPG2/Versican that result in an imbalance of splice variants. Mukhopadhyay A, etal., Invest Ophthalmol Vis Sci. 2006 Aug;47(8):3565-72.
12. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
13. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
14. GOA pipeline RGD automated data pipeline
15. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
16. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
17. The versican gene and the risk of intracranial aneurysms. Ruigrok YM, etal., Stroke. 2006 Sep;37(9):2372-4. Epub 2006 Aug 17.
18. Hormone-regulated expression and localization of versican in the rodent ovary. Russell DL, etal., Endocrinology 2003 Mar;144(3):1020-31.
19. Changes in distribution, cell associations, and protein expression levels of NG2, neurocan, phosphacan, brevican, versican V2, and tenascin-C during acute to chronic maturation of spinal cord scar tissue. Tang X, etal., J Neurosci Res 2003 Feb 1;71(3):427-44.
20. Versican is induced in infiltrating monocytes in myocardial infarction. Toeda K, etal., Mol Cell Biochem. 2005 Dec;280(1-2):47-56.
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PMID:9434070   PMID:9758703   PMID:12701107   PMID:14620382   PMID:15464361   PMID:15668231   PMID:16187070   PMID:16200461   PMID:16210410   PMID:16510873   PMID:16545622   PMID:16648628  
PMID:17972319   PMID:18431253   PMID:18616564   PMID:19437549   PMID:20489207   PMID:20551380   PMID:21976490   PMID:23658023   PMID:24006456   PMID:24719328   PMID:25845936   PMID:26152723  
PMID:26395512   PMID:27068509   PMID:27559042   PMID:29476059   PMID:31429356   PMID:32001344  



Vcan
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8222,497,035 - 22,595,955 (-)NCBIGRCr8
mRatBN7.2220,761,718 - 20,860,637 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl220,761,718 - 20,860,637 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx227,798,986 - 27,898,522 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0225,899,274 - 25,998,816 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0220,683,909 - 20,782,542 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0218,490,102 - 18,587,340 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl218,490,102 - 18,565,842 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0218,363,890 - 18,463,115 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4219,712,629 - 19,801,443 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1219,634,740 - 19,688,742 (-)NCBI
Celera216,903,548 - 17,002,158 (-)NCBICelera
Cytogenetic Map2q12NCBI
VCAN
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38583,471,744 - 83,582,302 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl583,471,618 - 83,582,303 (+)EnsemblGRCh38hg38GRCh38
GRCh37582,767,563 - 82,878,121 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36582,803,339 - 82,912,737 (+)NCBINCBI36Build 36hg18NCBI36
Build 34582,803,338 - 82,912,737NCBI
Celera578,672,557 - 78,783,162 (+)NCBICelera
Cytogenetic Map5q14.2-q14.3NCBI
HuRef577,975,785 - 78,086,373 (+)NCBIHuRef
CHM1_1582,200,193 - 82,311,247 (+)NCBICHM1_1
T2T-CHM13v2.0583,960,520 - 84,071,053 (+)NCBIT2T-CHM13v2.0
Vcan
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391389,803,429 - 89,891,146 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1389,803,431 - 89,890,628 (-)EnsemblGRCm39 Ensembl
GRCm381389,655,309 - 89,743,027 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1389,655,312 - 89,742,509 (-)EnsemblGRCm38mm10GRCm38
MGSCv371389,794,915 - 89,882,117 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361390,129,514 - 90,216,773 (-)NCBIMGSCv36mm8
Celera1393,253,094 - 93,340,280 (-)NCBICelera
Cytogenetic Map13C3NCBI
cM Map1345.5NCBI
Vcan
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_00495541826,967,595 - 27,078,430 (-)NCBIChiLan1.0ChiLan1.0
VCAN
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2431,721,703 - 31,832,599 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1529,875,328 - 29,986,197 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0531,699,278 - 31,810,169 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1532,019,709 - 32,130,350 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl532,019,709 - 32,130,351 (-)Ensemblpanpan1.1panPan2
VCAN
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1324,127,293 - 24,238,859 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl324,119,181 - 24,239,192 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha325,365,073 - 25,476,286 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0324,026,612 - 24,144,361 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl324,026,612 - 24,144,477 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1323,995,927 - 24,107,068 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0323,956,080 - 24,067,483 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0324,243,468 - 24,354,843 (-)NCBIUU_Cfam_GSD_1.0
Vcan
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213179,937,730 - 180,040,914 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364692,585,134 - 2,688,029 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364692,585,142 - 2,688,029 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
VCAN
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl291,384,391 - 91,811,208 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1291,682,177 - 91,811,674 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2293,783,322 - 93,895,492 (+)NCBISscrofa10.2Sscrofa10.2susScr3
VCAN
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1477,581,627 - 77,692,495 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl477,593,449 - 77,690,616 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604926,489,259 - 26,600,350 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Vcan
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247433,635,086 - 3,743,332 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

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Variants in Vcan
687 total Variants


Assembly: mRatBN7.2

Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Strain Variant Page
2 20798941 20798942 C T snv WKY/NCrl (2019), WKY/N (2020), BUF/MnaMcwi (2022), WKY/NCrl (2019NG), European Variation Archive Release 4, European Variation Archive Release 6, SHR/NHsd (2021), European Variation Archive Release 3 View more Information
2 20800394 20800395 A C snv ACI/EurMcwi (2019), ACI/N (2020), BXH2/CubMcwi (2020), BXH3/CubMcwi (2020), DA/OlaHsd (2019), F344/DuCrl (2019), F344/NCrl (2019), F344/N (2020), F344/Stm (2019), FHH/EurMcwi (2019), FXLE16/Stm (2020), FXLE18/Stm (2020), GK/FarMcwi (2019), HXB20/IpcvMcwi (2020), HXB31/IpcvMcwi (2019), LEW/Crl (2019), LEXF11/Stm (2020), LEXF1A/Stm (2019), LEXF1C/Stm (2019), LEXF2B/Stm (2019), LEXF3/Stm (2020), LEXF4/Stm (2020), LE/Stm (2019), LH/MavRrrcAek (2020), LL/MavRrrcAek (2020), LN/MavRrrcAek (2020), LEXF10A/StmMcwi (2020), MR/N (2020), MWF/Hsd (2019), PVG/Seac (2019), SHRSP/A3NCrl (2019), SHR/OlalpcvMcwi (2019), SR/JrHsd (2020), SS/JrHsdMcwi (2019), WKY/NCrl (2019), WKY/N (2020), WN/N (2020), ACI/EurMcwi (2019NG), BDIX/NemOdaMcwi (2022), BUF/MnaMcwi (2022), DA/OlaHsd (2019NG), F344/DuCrl (2019NG), F344/DuCrl (2019NG), F344/DuCrl (2021), European Variation Archive Release 3, European Variation Archive Release 4, LEXF2A/StmMcwi (2023), FXLE26/StmMcwi (2023), FXLE22/StmMcwi (2023), FXLE20/StmMcwi (2023), LEXF8D/StmMcwi (2023), BXH2/CubMcwi (2023), FXLE23/StmMcwi (2023), LEXF10C/StmMcwi (2023), FXLE17/StmMcwi (2023), LEXF6B/StmMcwi (2023), FXLE15/StmMcwi (2023), FXLE14/StmMcwi (2023), FXLE21/StmMcwi (2023), FXLE13/StmMcwi (2023), LEXF5/StmMcwi (2023), FXLE25/StmMcwi (2023), FXLE12/StmMcwi (2023), European Variation Archive Release 6, F344/NHsd (2021), F344/StmMcwi (2019), FHH/EurMcwi (2019NG), FXLE12/StmMcwi (2021), FXLE12/Stm (2019NG), FXLE13/Stm (2019NG), FXLE14/Stm (2019NG), FXLE15/StmMcwi (2021), FXLE15/Stm (2019NG), FXLE17/Stm (2019NG), FXLE19/StmMcwi (2022), FXLE20/Stm (2019NG), FXLE23/Stm (2022), FXLE25/Stm (2022), FXLE26/Stm (2022), GK/FarMcwi (2019NG), HXB18/IpcvMcwi (2021), LEW/Crl (2019NG), LEXF10B/StmMcwi (2022), LEXF10C/Stm (2022), LEXF1C/StmMcwi (2021), LEXF2A/Stm (2022), LEXF2C/StmMcwi (2022), LEXF5/Stm (2019NG), LEXF6B/Stm (2019NG), LEXF7A/Stm (2019NG), LEXF7B/StmMcwi (2022), LEXF7C/StmMcwi (2022), LEXF8A/StmMcwi (2021), LEXF8D/Stm (2022), LEXF9/StmMcwi (2022), MR/NRrrc (2022), MWF/SimwMcwi (2019NG), MWF/SimwMcwi (2019), SHRSP/A3NCrl (2019NG), SHR/NCrl (2021), SHR/NHsd (2021), SHR/NHsd (2021), SHR/OlalpcvMcwi (2019NG), SS/HsdMcwiCrl (2021), SS/JrHsdMcwi (2019NG), SS/JrHsd (2021), WKY/NCrl (2019NG) View more Information
2 20816442 20816443 A G snv MR/N (2020), PVG/Seac (2019), WKY/NCrl (2019), WKY/N (2020), WN/N (2020), WKY/NCrl (2019NG), European Variation Archive Release 3, European Variation Archive Release 4, European Variation Archive Release 6, MR/NRrrc (2022), SHR/NHsd (2021), BUF/MnaMcwi (2022) View more Information

Predicted Target Of
Summary Value
Count of predictions:1336
Count of miRNA genes:308
Interacting mature miRNAs:399
Transcripts:ENSRNOT00000045532, ENSRNOT00000063821, ENSRNOT00000067456
Prediction methods:Microtar, Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 13 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
10755430Coatc6Coat color QTL 60.02576coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)21159110056591100Rat
1600379Mcs18Mammary carcinoma susceptibility QTL 182.6mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)2788777242804738Rat
631682Bp115Blood pressure QTL 1154.30.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2137410502Rat
61355Bp36Blood pressure QTL 362.9blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)25873687102844969Rat
2300168Bmd47Bone mineral density QTL 476.60.0001femur mineral mass (VT:0010011)bone mineral density (CMO:0001226)22066244865662448Rat
10755499Bp389Blood pressure QTL 3892.61arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)218960362228801039Rat
1578664Bmd9Bone mineral QTL density 95femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)21185206249003364Rat
738010Lnnr3Liver neoplastic nodule remodeling QTL 32.94liver integrity trait (VT:0010547)liver remodeling tumorous lesion number (CMO:0001461)2141244106Rat
1357990Ael1Aortic elastin QTL 13.10.00091aorta elastin amount (VT:0003905)aortic elastin21907682564076825Rat
731167Glom4Glomerulus QTL 42.40.0082kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)22030467265304672Rat

1 to 10 of 13 rows
RH134008  
Rat AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map2q12UniSTS
RH143691  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2220,762,051 - 20,762,170 (+)MAPPERmRatBN7.2
Rnor_6.0218,490,436 - 18,490,554NCBIRnor6.0
Rnor_5.0218,364,224 - 18,364,342UniSTSRnor5.0
RGSC_v3.4219,712,963 - 19,713,081UniSTSRGSC3.4
Celera216,903,882 - 16,904,000UniSTS
Cytogenetic Map2q12UniSTS




alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31



Ensembl Acc Id: ENSRNOT00000045532   ⟹   ENSRNOP00000045935
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl220,761,718 - 20,860,539 (-)Ensembl
Rnor_6.0 Ensembl218,514,668 - 18,565,842 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000063821   ⟹   ENSRNOP00000062961
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl220,761,718 - 20,860,539 (-)Ensembl
Rnor_6.0 Ensembl218,490,102 - 18,565,842 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000067456   ⟹   ENSRNOP00000058873
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl220,761,718 - 20,860,539 (-)Ensembl
Rnor_6.0 Ensembl218,490,102 - 18,565,842 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000088313   ⟹   ENSRNOP00000074854
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl220,761,718 - 20,860,637 (-)Ensembl
Rnor_6.0 Ensembl218,492,018 - 18,531,210 (-)Ensembl
RefSeq Acc Id: NM_001170558   ⟹   NP_001164029
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8222,497,035 - 22,595,857 (-)NCBI
mRatBN7.2220,761,718 - 20,860,539 (-)NCBI
Rnor_6.0218,490,102 - 18,587,242 (-)NCBI
Rnor_5.0218,363,890 - 18,463,115 (-)NCBI
Celera216,903,548 - 17,002,060 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001170559   ⟹   NP_001164030
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8222,497,035 - 22,595,857 (-)NCBI
mRatBN7.2220,761,718 - 20,860,539 (-)NCBI
Rnor_6.0218,490,102 - 18,587,242 (-)NCBI
Rnor_5.0218,363,890 - 18,463,115 (-)NCBI
Celera216,903,548 - 17,002,060 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001170560   ⟹   NP_001164031
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8222,497,035 - 22,595,857 (-)NCBI
mRatBN7.2220,761,718 - 20,860,539 (-)NCBI
Rnor_6.0218,490,102 - 18,587,242 (-)NCBI
Rnor_5.0218,363,890 - 18,463,115 (-)NCBI
Celera216,903,548 - 17,002,060 (-)NCBI
Sequence:
RefSeq Acc Id: NM_053663   ⟹   NP_446115
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8222,497,035 - 22,595,955 (-)NCBI
mRatBN7.2220,761,718 - 20,860,637 (-)NCBI
Rnor_6.0218,490,102 - 18,587,340 (-)NCBI
Rnor_5.0218,363,890 - 18,463,115 (-)NCBI
Celera216,903,548 - 17,002,158 (-)NCBI
Sequence:
RefSeq Acc Id: NP_446115   ⟸   NM_053663
- Peptide Label: isoform 2 precursor
- UniProtKB: Q9R1K4 (UniProtKB/Swiss-Prot),   Q9ERB4 (UniProtKB/Swiss-Prot),   O88564 (UniProtKB/Swiss-Prot),   O08592 (UniProtKB/Swiss-Prot),   A0A0G2K944 (UniProtKB/TrEMBL),   A6I4N2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001164030   ⟸   NM_001170559
- Peptide Label: isoform 4 precursor
- UniProtKB: A6I4N1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001164031   ⟸   NM_001170560
- Peptide Label: isoform 3 precursor
- UniProtKB: D3Z9N6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001164029   ⟸   NM_001170558
- Peptide Label: isoform 1 precursor
- UniProtKB: D4A8Y6 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000058873   ⟸   ENSRNOT00000067456
C-type lectin   EGF-like   Ig-like   Ig-like V-type   Link   Sushi


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen



1 to 40 of 77 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-54903 BioCyc
Ensembl Genes ENSRNOG00000029212 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000045532 ENTREZGENE
  ENSRNOT00000063821 ENTREZGENE
  ENSRNOT00000063821.4 UniProtKB/Swiss-Prot
  ENSRNOT00000067456 ENTREZGENE
  ENSRNOT00000088313 ENTREZGENE
Gene3D-CATH 2.60.40.10 UniProtKB/Swiss-Prot
  3.10.100.10 UniProtKB/Swiss-Prot
  Complement Module, domain 1 UniProtKB/Swiss-Prot
  Laminin UniProtKB/Swiss-Prot
InterPro C-type_lectin-like UniProtKB/Swiss-Prot
  C-type_lectin-like/link_sf UniProtKB/Swiss-Prot
  C-type_lectin_CS UniProtKB/Swiss-Prot
  CSPG_CTLD UniProtKB/Swiss-Prot
  CTDL_fold UniProtKB/Swiss-Prot
  EGF-like_Ca-bd_dom UniProtKB/Swiss-Prot
  EGF-like_dom UniProtKB/Swiss-Prot
  EGF-type_Asp/Asn_hydroxyl_site UniProtKB/Swiss-Prot
  EGF_Ca-bd_CS UniProtKB/Swiss-Prot
  Hyaluronan_bind_Proteoglycan UniProtKB/Swiss-Prot
  Ig-like_dom UniProtKB/Swiss-Prot
  Ig-like_dom_sf UniProtKB/Swiss-Prot
  Ig-like_fold UniProtKB/Swiss-Prot
  Ig_sub UniProtKB/Swiss-Prot
  Ig_V-set UniProtKB/Swiss-Prot
  Link_dom UniProtKB/Swiss-Prot
  Sushi/SCR/CCP_sf UniProtKB/Swiss-Prot
  Sushi_SCR_CCP_dom UniProtKB/Swiss-Prot
KEGG Report rno:114122 UniProtKB/Swiss-Prot
NCBI Gene 114122 ENTREZGENE
PANTHER AGGRECAN/VERSICAN PROTEOGLYCAN UniProtKB/Swiss-Prot
  VERSICAN CORE PROTEIN UniProtKB/Swiss-Prot
Pfam EGF UniProtKB/Swiss-Prot
  Lectin_C UniProtKB/Swiss-Prot
  Sushi UniProtKB/Swiss-Prot
  V-set UniProtKB/Swiss-Prot
  Xlink UniProtKB/Swiss-Prot
PhenoGen Vcan PhenoGen
PRINTS LINKMODULE UniProtKB/Swiss-Prot
1 to 40 of 77 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-02-22 Vcan  versican  Cspg2  chondroitin sulfate proteoglycan 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-01-20 Cspg2  chondroitin sulfate proteoglycan 2    chondroitin sulfate proteoglycan 2 (versican)  Name updated 1299863 APPROVED
2002-08-07 Cspg2  chondroitin sulfate proteoglycan 2 (versican)      Symbol and Name status set to provisional 70820 PROVISIONAL

Note Type Note Reference
gene_expression present in vascular smooth muscle cells (SMCs) 632588
gene_expression localized around newly formed corpora lutea and vasculature immediately after ovulation 1299255
gene_regulation FSH and testosterone increase mRNA expression in ovarian tissue 1299255