Dlk1 (delta like non-canonical Notch ligand 1)

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Gene: Dlk1 (delta like non-canonical Notch ligand 1) Rattus norvegicus

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Symbol:

Dlk1

Name:

delta like non-canonical Notch ligand 1

RGD ID:

619931

Description:

Predicted to enable calcium ion binding activity. Involved in cell differentiation. Predicted to be located in external side of plasma membrane and extracellular space. Predicted to be active in membrane. Orthologous to human DLK1 (delta like non-canonical Notch ligand 1); PARTICIPATES IN forkhead class A signaling pathway; Notch signaling pathway; p38 MAPK signaling pathway; INTERACTS WITH 17alpha-ethynylestradiol; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

delta-like 1; delta-like 1 homolog; delta-like 1 homolog (Drosophila); delta-like homolog (Drosophila); DLK-1; preadipocyte factor 1; preadipocyte factor-1; Pref-1; protein delta homolog 1; Zog

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	6	134,192,491 - 134,199,779 (+)	NCBI		GRCr8
mRatBN7.2	6	128,410,216 - 128,417,518 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	6	128,410,316 - 128,417,522 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	6	128,550,763 - 128,557,963 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	6	128,846,606 - 128,853,806 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	6	128,207,854 - 128,215,027 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	6	133,576,513 - 133,583,751 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	6	133,552,821 - 133,583,751 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	6	142,742,149 - 142,749,166 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	6	134,022,016 - 134,043,058 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	6	134,028,202 - 134,035,262 (+)	NCBI
Celera	6	125,960,411 - 125,967,475 (+)	NCBI		Celera
Cytogenetic Map	6	q32	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

biliary atresia (ISO)

central precocious puberty (ISO)

Experimental Autoimmune Encephalomyelitis (ISO)

Fetal Growth Retardation (ISO)

genetic disease (ISO)

hepatocellular carcinoma (ISO)

high grade glioma (ISO)

Kagami-Ogata syndrome (ISO)

myelodysplastic syndrome (ISO)

Silver-Russell Syndrome 1 (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,2-dimethylhydrazine (ISO)

1,4-bis(2-ethylhexyl) sulfosuccinate (ISO)

17alpha-ethynylestradiol (EXP)

17beta-estradiol (EXP,ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2-acetamidofluorene (EXP)

2-amino-2-deoxy-D-glucopyranose 6-phosphate (ISO)

2-methylcholine (ISO)

3,3',4,4',5-pentachlorobiphenyl (EXP)

3,3',5,5'-tetrabromobisphenol A (ISO)

3-isobutyl-1-methyl-7H-xanthine (ISO)

4,4'-sulfonyldiphenol (ISO)

5-aza-2'-deoxycytidine (ISO)

5-azacytidine (ISO)

5-fluorouracil (ISO)

6-propyl-2-thiouracil (EXP)

aflatoxin B1 (ISO)

aldehydo-D-glucosamine 6-phosphate (ISO)

aldehydo-D-glucose (ISO)

all-trans-retinoic acid (ISO)

amitrole (EXP)

arsane (ISO)

arsenic atom (ISO)

arsenous acid (ISO)

atrazine (ISO)

baicalein (ISO)

benzalkonium chloride (ISO)

benzo[a]pyrene (ISO)

benzo[e]pyrene (ISO)

bezafibrate (EXP)

bis(2-ethylhexyl) phthalate (ISO)

bisphenol A (EXP,ISO)

Bisphenol A diglycidyl ether (ISO)

bisphenol F (ISO)

bleomycin A2 (ISO)

carbamazepine (ISO)

chlorpyrifos (ISO)

cisplatin (ISO)

cobalt atom (ISO)

copper atom (EXP)

copper(0) (EXP)

copper(II) sulfate (ISO)

Cuprizon (EXP)

cyclosporin A (ISO)

D-glucose (ISO)

dexamethasone (EXP,ISO)

dextran sulfate (ISO)

diarsenic trioxide (ISO)

diethylstilbestrol (EXP)

dorsomorphin (ISO)

doxorubicin (ISO)

entinostat (ISO)

ethanol (ISO)

fipronil (EXP)

flavonoids (EXP)

folic acid (ISO)

fructose (ISO)

genistein (ISO)

glucose (ISO)

glycidol (EXP)

glyphosate (ISO)

herbicide (ISO)

hydrogen peroxide (ISO)

indometacin (ISO)

inulin (ISO)

ketoconazole (EXP)

lead(0) (ISO)

lipopolysaccharide (ISO)

manganese(II) chloride (ISO)

methapyrilene (ISO)

methylmercury chloride (ISO)

monosodium L-glutamate (EXP)

N-methyl-4-phenylpyridinium (ISO)

panobinostat (ISO)

paraquat (EXP)

pentanal (ISO)

perfluorooctane-1-sulfonic acid (ISO)

phenylmercury acetate (ISO)

phorbol 13-acetate 12-myristate (ISO)

prednisone (ISO)

pregnenolone 16alpha-carbonitrile (EXP)

resveratrol (ISO)

rotenone (ISO)

sarin (ISO)

SB 431542 (ISO)

silibinin (ISO)

silicon dioxide (EXP,ISO)

sodium arsenite (ISO)

sunitinib (ISO)

tetrachloromethane (ISO)

thalidomide (ISO)

thapsigargin (ISO)

titanium dioxide (EXP,ISO)

tributylstannane (ISO)

trichostatin A (ISO)

triflumizole (ISO)

tunicamycin (ISO)

valproic acid (ISO)

vorinostat (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

bone mineralization (ISO)

cell differentiation (IDA)

embryonic skeletal system development (ISO)

multicellular organism growth (ISO)

negative regulation of fat cell differentiation (ISO)

negative regulation of Notch signaling pathway (IBA,ISO)

negative regulation of vascular endothelial cell proliferation (ISO)

ossification (ISO)

osteoblast differentiation (ISO)

positive regulation of bone resorption (ISO)

positive regulation of cytokine production (ISO)

post-embryonic development (ISO)

regulation of gene expression (ISO)

Cellular Component

cytoplasm (IEA)

external side of plasma membrane (ISO)

extracellular space (ISO)

membrane (IBA,IEA)

Molecular Function

calcium ion binding (IEA)

protein binding (IPI,ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

forkhead class A signaling pathway (ISO)

Notch signaling pathway (ISO)

p38 MAPK signaling pathway (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Growth hormone and prolactin stimulate the expression of rat preadipocyte factor-1/delta-like protein in pancreatic islets: molecular cloning and expression pattern during development and growth of the endocrine pancreas.	Carlsson C, etal., Endocrinology 1997 Sep;138(9):3940-8.
2.	Mechanisms and functions of p38 MAPK signalling.	Cuadrado A and Nebreda AR, Biochem J. 2010 Aug 1;429(3):403-17. doi: 10.1042/BJ20100323.
3.	Hepatocyte-Specific Arid1a Deficiency Initiates Mouse Steatohepatitis and Hepatocellular Carcinoma.	Fang JZ, etal., PLoS One. 2015 Nov 16;10(11):e0143042. doi: 10.1371/journal.pone.0143042. eCollection 2015.
4.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
6.	Cloning of a membrane-spanning protein with epidermal growth factor-like repeat motifs from adrenal glomerulosa cells.	Halder SK, etal., Endocrinology 1998 Jul;139(7):3316-28.
7.	The human Delta-like 1 homologue is implicated in the progression of liver fibrosis in biliary atresia.	Huang CC, etal., J Pathol. 2004 Feb;202(2):172-9.
8.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
9.	Electronic Transfer of LocusLink and RefSeq Data	NCBI rat LocusLink and RefSeq merged data July 26, 2002
10.	PID Annotation Import Pipeline	Pipeline to import Pathway Interaction Database annotations from NCI into RGD
11.	GOA pipeline	RGD automated data pipeline
12.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
13.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
14.	Comprehensive gene review and curation	RGD comprehensive gene curation
15.	Parent-of-origin effects implicate epigenetic regulation of experimental autoimmune encephalomyelitis and identify imprinted Dlk1 as a novel risk gene.	Stridh P, etal., PLoS Genet. 2014 Mar 27;10(3):e1004265. doi: 10.1371/journal.pgen.1004265. eCollection 2014 Mar.
16.	Sh3rf2/POSHER protein promotes cell survival by ring-mediated proteasomal degradation of the c-Jun N-terminal kinase scaffold POSH (Plenty of SH3s) protein.	Wilhelm M, etal., J Biol Chem. 2012 Jan 13;287(3):2247-56. doi: 10.1074/jbc.M111.269431. Epub 2011 Nov 28.
17.	DLK1: increased expression in gliomas and associated with oncogenic activities.	Yin D, etal., Oncogene. 2006 Mar 23;25(13):1852-61.

Additional References at PubMed

PMID:7925474	PMID:8500166	PMID:12477932	PMID:12655782	PMID:18751720	PMID:18988804	PMID:19084046	PMID:19247431	PMID:19515692	PMID:19661059	PMID:21308776	PMID:21419176
PMID:22298767	PMID:23387476	PMID:24584117	PMID:24913911	PMID:25093684	PMID:25268256	PMID:25342302	PMID:25723595	PMID:27044861	PMID:29453913	PMID:30145985	PMID:31091532
PMID:33472171	PMID:35050550

Genomics

Comparative Map Data

Dlk1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	6	134,192,491 - 134,199,779 (+)	NCBI		GRCr8
mRatBN7.2	6	128,410,216 - 128,417,518 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	6	128,410,316 - 128,417,522 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	6	128,550,763 - 128,557,963 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	6	128,846,606 - 128,853,806 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	6	128,207,854 - 128,215,027 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	6	133,576,513 - 133,583,751 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	6	133,552,821 - 133,583,751 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	6	142,742,149 - 142,749,166 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	6	134,022,016 - 134,043,058 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	6	134,028,202 - 134,035,262 (+)	NCBI
Celera	6	125,960,411 - 125,967,475 (+)	NCBI		Celera
Cytogenetic Map	6	q32	NCBI

DLK1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	14	100,726,892 - 100,738,224 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	14	100,725,705 - 100,738,224 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	14	101,193,229 - 101,204,561 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	14	100,263,006 - 100,271,213 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	14	100,263,005 - 100,271,210	NCBI
Celera	14	81,247,286 - 81,255,551 (+)	NCBI		Celera
Cytogenetic Map	14	q32.2	NCBI
HuRef	14	81,373,717 - 81,381,968 (+)	NCBI		HuRef
CHM1_1	14	101,130,974 - 101,139,248 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	14	94,961,805 - 94,973,139 (+)	NCBI		T2T-CHM13v2.0

Dlk1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	12	109,418,411 - 109,429,262 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	12	109,418,749 - 109,429,262 (+)	Ensembl		GRCm39 Ensembl
GRCm38	12	109,452,485 - 109,463,336 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	12	109,452,823 - 109,463,336 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	12	110,691,033 - 110,701,546 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	12	109,901,030 - 109,908,498 (+)	NCBI		MGSCv36	mm8
Celera	12	110,648,411 - 110,658,915 (+)	NCBI		Celera
Cytogenetic Map	12	F1	NCBI
cM Map	12	60.17	NCBI

Dlk1
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955627	38,128 - 43,728 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955627	37,886 - 43,730 (-)	NCBI	ChiLan1.0	ChiLan1.0

DLK1
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	15	101,879,300 - 101,887,554 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	14	101,095,796 - 101,104,047 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	14	81,348,380 - 81,356,607 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	14	100,654,965 - 100,668,020 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	14	100,654,965 - 100,668,019 (+)	Ensembl	panpan1.1		panPan2

DLK1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	8	68,961,975 - 68,970,106 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	8	68,961,744 - 68,972,761 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	8	68,479,790 - 68,487,872 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	8	69,245,619 - 69,253,709 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	8	69,245,491 - 69,256,384 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	8	68,906,950 - 68,915,034 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	8	68,973,041 - 68,981,107 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	8	69,370,948 - 69,379,035 (+)	NCBI		UU_Cfam_GSD_1.0

Dlk1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024408640	5,567,786 - 5,578,803 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936604	4,504,503 - 4,511,910 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936604	4,504,519 - 4,511,897 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

DLK1
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	7	121,565,854 - 121,576,654 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	7	121,565,844 - 121,577,493 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	7	132,339,547 - 132,345,907 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

DLK1
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	24	78,687,542 - 78,695,782 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	24	78,687,668 - 78,695,607 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666053	65,824,853 - 65,833,295 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Dlk1
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624734	3,363,001 - 3,372,694 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624734	3,363,084 - 3,372,790 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Dlk1
18 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	81
Count of miRNA genes:	59
Interacting mature miRNAs:	63
Transcripts:	ENSRNOT00000006339
Prediction methods:	Microtar, Miranda, Rnahybrid
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
12801411	Schws8	Schwannoma susceptibility QTL 8			nervous system integrity trait (VT:0010566)	percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)	6	94968928	139968928	Rat
1331797	Bp213	Blood pressure QTL 213	3.291		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	6	104085867	128713626	Rat
1331799	Bp211	Blood pressure QTL 211	3.66407		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	6	72202632	130919985	Rat
71111	Iddm8	Insulin dependent diabetes mellitus QTL 8	1.9	0.002	blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	6	105156861	140994061	Rat
1358355	Srcrt4	Stress Responsive Cort QTL 4	6.39		blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	6	100364669	140994061	Rat
61329	Eae9	Experimental allergic encephalomyelitis QTL 9	3.7		body mass (VT:0001259)	change in body weight (CMO:0002045)	6	122549046	140994061	Rat
2312560	Pur20	Proteinuria QTL 20	2.1	0.005	urine total protein amount (VT:0000032)	urine total protein excretion rate (CMO:0000756)	6	125628133	137801795	Rat
2313399	Anxrr28	Anxiety related response QTL 28			aggression-related behavior trait (VT:0015014)	tameness/aggressiveness composite score (CMO:0002136)	6	100671796	132340886	Rat
1331725	Bp212	Blood pressure QTL 212	3.52475		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	6	93701310	128713626	Rat
8552796	Vie3	Viral induced encephalitis QTL 3	2.6		brain integrity trait (VT:0010579)	encephalitis incidence/prevalence measurement (CMO:0002361)	6	96833997	140994061	Rat
4145118	Mcs26	Mammary carcinoma susceptibility QTL 26		0.0001	mammary gland integrity trait (VT:0010552)	post-insult time to mammary tumor formation (CMO:0000345)	6	106752656	132339866	Rat
1581563	Uae33	Urinary albumin excretion QTL 33			urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	6	72227641	130729205	Rat
10054138	Gmadr3	Adrenal mass QTL 3	3.68	0.00045	adrenal gland mass (VT:0010420)	both adrenal glands wet weight (CMO:0000164)	6	85140138	130140138	Rat
1641917	Colcr5	Colorectal carcinoma resistance QTL 5	3.18	0.0009	intestine integrity trait (VT:0010554)	benign colorectal tumor number (CMO:0001795)	6	122549046	137801795	Rat
61414	Pia3	Pristane induced arthritis QTL 3	4.5		joint integrity trait (VT:0010548)	post-insult time to onset of experimental arthritis (CMO:0001450)	6	94968928	137848904	Rat
724513	Uae14	Urinary albumin excretion QTL 14	6.5		urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	6	85311061	133478515	Rat
2303624	Vencon5	Ventilatory control QTL 5	4.45		respiration trait (VT:0001943)	minute ventilation (CMO:0000132)	6	88047916	133047916	Rat
731173	Uae22	Urinary albumin excretion QTL 22	10.1		urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	6	65531555	140994061	Rat
10054123	Srcrt6	Stress Responsive Cort QTL 6	2.5	0.0043	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	6	85140138	130140138	Rat
724536	Uae7	Urinary albumin excretion QTL 7	3.5		urine albumin amount (VT:0002871)	urine albumin level (CMO:0000130)	6	72202632	130729475	Rat
737976	Pia24	Pristane induced arthritis QTL 24			joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	6	112636280	140994061	Rat
1298087	Iddm18	Insulin dependent diabetes mellitus QTL 18		0.0001	urine glucose amount (VT:0001758)	percentage of study population developing diabetes mellitus during a period of time (CMO:0001114)	6	116506292	130245370	Rat
1581550	Pur8	Proteinuria QTL 8			urine total protein amount (VT:0000032)	urine total protein excretion rate (CMO:0000756)	6	72227641	130729205	Rat
738034	Anxrr5	Anxiety related response QTL 5	5.9		exploratory behavior trait (VT:0010471)	percentage of entries into a discrete space in an experimental apparatus (CMO:0000961)	6	84130881	129130881	Rat
2290393	Uae37	Urinary albumin excretion QTL 37		0.0001	urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	6	65531555	140994061	Rat
1300076	Glom8	Glomerulus QTL 8	7	9e-09	kidney glomerulus morphology trait (VT:0005325)	count of superficial glomeruli directly contacting the kidney surface (CMO:0001001)	6	86894788	131894788	Rat
2293085	Iddm29	Insulin dependent diabetes mellitus QTL 29	7.66		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	6	122549046	140286318	Rat

Markers in Region

BE115497

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	6	128,417,114 - 128,417,264 (+)	MAPPER	mRatBN7.2
Rnor_6.0	6	133,583,346 - 133,583,495	NCBI	Rnor6.0
Rnor_5.0	6	142,748,927 - 142,749,076	UniSTS	Rnor5.0
RGSC_v3.4	6	134,028,833 - 134,028,982	UniSTS	RGSC3.4
Celera	6	125,967,189 - 125,967,338	UniSTS
RH 3.4 Map	6	791.5	UniSTS
Cytogenetic Map	6	q32	UniSTS

UniSTS:259449

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	6	128,416,706 - 128,417,270 (+)	MAPPER	mRatBN7.2
Rnor_6.0	6	133,582,938 - 133,583,501	NCBI	Rnor6.0
Rnor_5.0	6	142,748,519 - 142,749,082	UniSTS	Rnor5.0
RGSC_v3.4	6	134,028,425 - 134,028,988	UniSTS	RGSC3.4
Celera	6	125,966,781 - 125,967,344	UniSTS
Cytogenetic Map	6	q32	UniSTS

Dlk1

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	6	128,416,794 - 128,417,010 (+)	MAPPER	mRatBN7.2
Rnor_6.0	6	133,583,026 - 133,583,241	NCBI	Rnor6.0
Rnor_5.0	6	142,748,607 - 142,748,822	UniSTS	Rnor5.0
RGSC_v3.4	6	134,028,513 - 134,028,728	UniSTS	RGSC3.4
Celera	6	125,966,869 - 125,967,084	UniSTS
Cytogenetic Map	6	q32	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	nervous system	renal system	reproductive system	respiratory system
9	11	48	113	85	84	53	24	53	6	204	95	93	39	60	31

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_053744	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_008764917	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063261397	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AB046763	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC167752	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	D84336	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000006	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	U25680	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000006339 ⟹ ENSRNOP00000006339

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	6	128,410,969 - 128,417,522 (+)	Ensembl
Rnor_6.0 Ensembl	6	133,552,821 - 133,583,498 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000085933 ⟹ ENSRNOP00000069391

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	6	128,410,316 - 128,417,522 (+)	Ensembl
Rnor_6.0 Ensembl	6	133,576,568 - 133,583,751 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000107076 ⟹ ENSRNOP00000086145

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	6	128,410,316 - 128,417,267 (+)	Ensembl

RefSeq Acc Id:

NM_053744 ⟹ NP_446196

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	6	134,192,597 - 134,199,779 (+)	NCBI
mRatBN7.2	6	128,410,335 - 128,417,518 (+)	NCBI
Rnor_6.0	6	133,576,568 - 133,583,751 (+)	NCBI
Rnor_5.0	6	142,742,149 - 142,749,166 (+)	NCBI
RGSC_v3.4	6	134,022,016 - 134,043,058 (+)	RGD
Celera	6	125,960,411 - 125,967,475 (+)	NCBI

Sequence:

show sequence

CCCGGTGCAACCCTGGCTTTCTTTCCGCTGGACACCCGTGCCCCCTTCGTGGTCCGCAACCAGA
AGCCCAGCGCAGCCCCGGAGCAGCCCCTGCACCGCCACCGCTACCCGGACCACGACCCAGGCCG
CCCCGAGATGATCGCGACCGGAGCCCTCCTGCGCGTCCTCTTGCTCCTGCTGGCTTTCGGCCAC
AGCACCTATGGGGCTGAGTGCGACCCGGCCTGTGACCCTCAGCATGGATTCTGTGAGGCTGACA
ATGTCTGCAGGTGTGAGCCTGGCTGGGAGGGCCCCCTGTGTGAGAAGTGCGTAACCTCCCCTGG
CTGTGTTAATGGACTCTGTGAAGAACCATGGCAGTGTGTCTGCAAGGAAGGCTGGGACGGGAAA
TTCTGCGAAATAGATATTCGGGCTTGCACCTCTACCCCCTGCGCCAACAATGGGACTTGCGTGG
ACCTCGAGAAAGGCCAGTACGAATGCTCCTGCACCCCTGGATTCTCTGGAAAGGACTGTCAGCA
CAAGGCTGGGCCCTGCGTGATCAATGGTTCTCCCTGCCAGCACGGAGGCGCCTGCGTGGATGAT
GAGGGCCGGGCCTCGCATGCTTCCTGCCTGTGCCCCCCTGGCTTCTCGGGCAACTTCTGTGAGA
TCGTGACCAACAGCTGTACCCCTAACCCATGCGAGAACGATGGCGTCTGCACCGACATCGGGGG
CGACTTCCGTTGCCGCTGCCCAGCTGGATTCGTCGACAAGACCTGCAGCCGTCCGGTGAGCAAC
TGCGCCAGTGGCCCGTGCCTGAACGGGGGCACCTGCCTCCAGCACACCCAGGTGAGCTTCGAGT
GTCTGTGCAAGCCCCCGTTCATGGGTCCCACATGCGCGAAGAAGCGCGGGACCAGCCCCGTGCA
GGTCACCCACCTACCCAGCGGCTACGGGCTCACCTACCGCCTGACCCCCGGGGTGCACGAGCTA
CCTGTCCAGCAGCCCGAGCACCACATCCTGAAGGTGTCCATGAAAGAGCTCAACAAGAGTGCCC
CTCTCCTCACCGAGGGACAGGCCATCTGCTTCACCATCCTGGGCGTGCTCACCAGCCTGGTTGT
GCTGGGCACCGTGGCCATCGTCTTTCTCAACAAGTGCGAGGCCTGGGTGTCCAACCTGCGCTAC
AACCACATGCTTCGCAAGAAGAAGAACCTGCTGTTGCAGTACAACAGCGGCGAGGAGCTGGCGG
TCAATATCATCTTCCCGGAGAAGATCGACATGACCACCTTCAACAAGGAGGCTGGTGATGAGGA
TATCTAAGCAGCGTGTCCCCTCCCCCTCCCCCAGGCCCTTCTACATTATCGGGGTTCCTCACAG
CTCCCTCTATGCGCTCTATGCTTCTTTGTGGTGGAGTTCGCTCTTGTGTGGAATCTAGTGAACG
CTACGCTTACATTTATTTTCTCGTGTTGCTGTGTGACAAGCTGCCGCTAAGAACCCCTCCCTCC
CTCCCTCCCTCCCTCCCTATTAATGCATGATATAATGAATAATAATAAGAATTTCATCTCTAAA
TG

hide sequence

RefSeq Acc Id:

XM_008764917 ⟹ XP_008763139

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	6	134,192,491 - 134,199,777 (+)	NCBI
mRatBN7.2	6	128,410,216 - 128,417,397 (+)	NCBI
Rnor_6.0	6	133,576,513 - 133,583,742 (+)	NCBI

Sequence:

show sequence

GCGGCGCGCGGGCCGCAGCGGCAGCTCCTCGGCAGCCGCACTTAGTAGCGTGCGCCCCGGTGCA
ACCCTGGCTTTCTTTCCGCTGGACACCCGTGCCCCCTTCGTGGTCCGCAACCAGAAGCCCAGCG
CAGCCCCCGGAGCAGCCCCTGCACCGCCACCGCTACCCGGACCACGACCCAGGCCGCCCCGAGA
TGATCGCGACCGGAGCCCTCCTGCGCGTCCTCTTGCTCCTGCTGGCTTTCGGCCACAGCACCTA
TGGGGCTGAGTGCGACCCGGCCTGTGACCCTCAGCATGGATTCTGTGAGGCTGACAATGTCTGC
AGGTGTGAGCCTGGCTGGGAGGGCCCCCTGTGTGAGAAGTGCGTAACCTCCCCTGGCTGTGTTA
ATGGACTCTGTGAAGAACCATGGCAGTGTGTCTGCAAGGAAGGCTGGGACGGGAAATTCTGCGA
AATAGATATTCGGGCTTGCACCTCTACCCCCTGCGCCAACAATGGGACTTGCGTGGACCTCGAG
AAAGGCCAGTACGAATGCTCCTGCACCCCTGGATTCTCTGGAAAGGACTGTCAGCACAAGGCTG
GGCCCTGCGTGATCAATGGTTCTCCCTGCCAGCACGGAGGCGCCTGCGTGGATGATGAGGGCCG
GGCCTCGCATGCTTCCTGCCTGTGCCCCCCTGGCTTCTCGGGCAACTTCTGTGAGATCGTGACC
AACAGCTGTACCCCTAACCCATGCGAGAACGATGGCGTCTGCACCGACATCGGGGGCGACTTCC
GTTGCCGCTGCCCAGCTGGATTCGTCGACAAGACCTGCAGCCGTCCGGTGAGCAACTGCGCCAG
TGGCCCGTGCCTGAACGGGGGCACCTGCCTCCAGCACACCCAGCCCGAGCACCACATCCTGAAG
GTGTCCATGAAAGAGCTCAACAAGAGTGCCCCTCTCCTCACCGAGGGACAGGCCATCTGCTTCA
CCATCCTGGGCGTGCTCACCAGCCTGGTTGTGCTGGGCACCGTGGCCATCGTCTTTCTCAACAA
GTGCGAGGCCTGGGTGTCCAACCTGCGCTACAACCACATGCTTCGCAAGAAGAAGAACCTGCTG
TTGCAGTACAACAGCGGCGAGGAGCTGGCGGTCAATATCATCTTCCCGGAGAAGATCGACATGA
CCACCTTCAACAAGGAGGCTGGTGATGAGGATATCTAAGCAGCGTGTCCCCTCCCCCTCCCCCA
GGCCCTTCTACATTATCGGGGTTCCTCACAGCTCCCTCTATGCGCTCTATGCTTCTTTGTGGGT
GGATTCGCTCATTGTGTGGATCTAGTGAACGCTAGCTTACATTTATTGTCTCGTGTTGCTGTGT
GACAAGCTTGCCGCTAAGAACCCCTCCGCCTCCCTCCCTCCCTCCTCCTATTAATCGCATAGAT
ATTAATGGAATAATAATAAGATTTCA

hide sequence

RefSeq Acc Id:

XM_063261397 ⟹ XP_063117467

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	6	134,192,503 - 134,199,777 (+)	NCBI

Protein Sequences


Protein RefSeqs	NP_446196	(Get FASTA)	NCBI Sequence Viewer
	XP_008763139	(Get FASTA)	NCBI Sequence Viewer
	XP_063117467	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAB87095	(Get FASTA)	NCBI Sequence Viewer
	AAI67752	(Get FASTA)	NCBI Sequence Viewer
	BAA25881	(Get FASTA)	NCBI Sequence Viewer
	BAB12399	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000006339.5
	ENSRNOP00000069391.1
	ENSRNOP00000086145.1
	ENSRNOP00055039933
	ENSRNOP00060023942
	ENSRNOP00065036922
GenBank Protein	O70534	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:	NP_446196 ⟸ NM_053744
- Peptide Label:	precursor
- UniProtKB:	Q62779 (UniProtKB/Swiss-Prot), O70534 (UniProtKB/TrEMBL), A6KBJ4 (UniProtKB/TrEMBL)
- Sequence:	show sequence MIATGALLRVLLLLLAFGHSTYGAECDPACDPQHGFCEADNVCRCEPGWEGPLCEKCVTSPGCV NGLCEEPWQCVCKEGWDGKFCEIDIRACTSTPCANNGTCVDLEKGQYECSCTPGFSGKDCQHKA GPCVINGSPCQHGGACVDDEGRASHASCLCPPGFSGNFCEIVTNSCTPNPCENDGVCTDIGGDF RCRCPAGFVDKTCSRPVSNCASGPCLNGGTCLQHTQVSFECLCKPPFMGPTCAKKRGTSPVQVT HLPSGYGLTYRLTPGVHELPVQQPEHHILKVSMKELNKSAPLLTEGQAICFTILGVLTSLVVLG TVAIVFLNKCEAWVSNLRYNHMLRKKKNLLLQYNSGEELAVNIIFPEKIDMTTFNKEAGDEDI hide sequence

RefSeq Acc Id:	XP_008763139 ⟸ XM_008764917
- Peptide Label:	isoform X1
- UniProtKB:	A0A8I6GDQ5 (UniProtKB/TrEMBL), A6KBJ4 (UniProtKB/TrEMBL)
- Sequence:	show sequence MIATGALLRVLLLLLAFGHSTYGAECDPACDPQHGFCEADNVCRCEPGWEGPLCEKCVTSPGCV NGLCEEPWQCVCKEGWDGKFCEIDIRACTSTPCANNGTCVDLEKGQYECSCTPGFSGKDCQHKA GPCVINGSPCQHGGACVDDEGRASHASCLCPPGFSGNFCEIVTNSCTPNPCENDGVCTDIGGDF RCRCPAGFVDKTCSRPVSNCASGPCLNGGTCLQHTQPEHHILKVSMKELNKSAPLLTEGQAICF TILGVLTSLVVLGTVAIVFLNKCEAWVSNLRYNHMLRKKKNLLLQYNSGEELAVNIIFPEKIDM TTFNKEAGDEDI hide sequence

Ensembl Acc Id:

ENSRNOP00000006339 ⟸ ENSRNOT00000006339

Ensembl Acc Id:

ENSRNOP00000069391 ⟸ ENSRNOT00000085933

Ensembl Acc Id:

ENSRNOP00000086145 ⟸ ENSRNOT00000107076

RefSeq Acc Id:	XP_063117467 ⟸ XM_063261397
- Peptide Label:	isoform X2

Protein Domains

EGF-like

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-O70534-F1-model_v2	AlphaFold	O70534	1-383	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13694825

Promoter ID:

EPDNEW_R5349

Type:

single initiation site

Name:

Dlk1_1

Description:

delta like non-canonical Notch ligand 1

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	6	133,576,535 - 133,576,595	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:619931	AgrOrtholog
BioCyc Gene	G2FUF-36264	BioCyc
Ensembl Genes	ENSRNOG00000019584	Ensembl, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	ENSRNOG00055028031	UniProtKB/Swiss-Prot
	ENSRNOG00060017366	UniProtKB/Swiss-Prot
	ENSRNOG00065026096	UniProtKB/Swiss-Prot
Ensembl Transcript	ENSRNOT00000006339.7	UniProtKB/TrEMBL
	ENSRNOT00000085933.2	UniProtKB/Swiss-Prot
	ENSRNOT00000107076.1	UniProtKB/TrEMBL
	ENSRNOT00055048579	UniProtKB/Swiss-Prot
	ENSRNOT00060029726	UniProtKB/Swiss-Prot
	ENSRNOT00065045038	UniProtKB/Swiss-Prot
Gene3D-CATH	Laminin	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE	IMAGE:8365650	IMAGE-MGC_LOAD
InterPro	EGF-like_Ca-bd_dom	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	EGF-like_CS	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	EGF-like_dom	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	EGF-type_Asp/Asn_hydroxyl_site	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	MEGF_diff_regulators	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	rno:114587	UniProtKB/Swiss-Prot
MGC_CLONE	MGC:187346	IMAGE-MGC_LOAD
NCBI Gene	114587	ENTREZGENE
PANTHER	DELTA-RELATED	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	NIMROD A, ISOFORM E	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam	DL-JAG_EGF-like	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	EGF	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	hEGF	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen	Dlk1	PhenoGen
PRINTS	EGFBLOOD	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE	ASX_HYDROXYL	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	EGF_1	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	EGF_2	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	EGF_3	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000019584	RatGTEx
	ENSRNOG00055028031	RatGTEx
	ENSRNOG00060017366	RatGTEx
	ENSRNOG00065026096	RatGTEx
SMART	EGF	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	EGF_CA	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP	EGF/Laminin	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt	A0A8I6GDQ5	ENTREZGENE, UniProtKB/TrEMBL
	A0A8L2Q3B5_RAT	UniProtKB/TrEMBL
	A6KBJ4	ENTREZGENE, UniProtKB/TrEMBL
	DLK1_RAT	UniProtKB/Swiss-Prot, ENTREZGENE
	Q62779	ENTREZGENE
UniProt Secondary	Q62779	UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2016-05-20	Dlk1	delta like non-canonical Notch ligand 1	Dlk1	delta-like 1 homolog (Drosophila)	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2004-09-10	Dlk1	delta-like 1 homolog (Drosophila)		delta-like homolog (Drosophila)	Name updated	1299863	APPROVED
2002-08-07	Dlk1	delta-like homolog (Drosophila)			Symbol and Name status set to provisional	70820	PROVISIONAL

RGD Curation Notes

Note Type	Note	Reference
gene_process	involved in both differentiation and growth of beta-cells	632566

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

RGD Manual Annotations

Imported Annotations - PID (archival)

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

RGD Manual Annotations

Imported Annotations - PID (archival)