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Gene: Dynlrb1 (dynein light chain roadblock-type 1) Rattus norvegicus

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Symbol:

Dynlrb1

Name:

dynein light chain roadblock-type 1

RGD ID:

619910

Description:

Predicted to enable dynein intermediate chain binding activity and identical protein binding activity. Involved in visual behavior. Located in cytoplasm. Orthologous to human DYNLRB1 (dynein light chain roadblock-type 1); PARTICIPATES IN mitochondria transport pathway; transforming growth factor-beta Smad dependent signaling pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 4,4'-sulfonyldiphenol; acrylamide.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

bithoraxoid-like protein; BLP; Dncl2a; dynein light chain 2A, cytoplasmic; dynein, cytoplasmic, light chain 2A; dynein-associated protein Km23; dynein-associated protein RKM23; km23; robl/LC7-like

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	DYNLRB1 (dynein light chain roadblock-type 1)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, Panther, PhylomeDB
Mus musculus (house mouse):	Dynlrb1 (dynein light chain roadblock-type 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Dynlrb1 (dynein light chain roadblock-type 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	DYNLRB1 (dynein light chain roadblock-type 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	DYNLRB1 (dynein light chain roadblock-type 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Dynlrb1 (dynein light chain roadblock-type 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	DYNLRB1 (dynein light chain roadblock-type 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	DYNLRB1 (dynein light chain roadblock-type 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Dynlrb1 (dynein light chain roadblock-type 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus rattus (black rat):	Dynlrb1 (dynein light chain roadblock-type 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Other homologs ²
Homo sapiens (human):	DYNLRB2 (dynein light chain roadblock-type 2)	HGNC	OrthoDB
Homo sapiens (human):	RPL7A (ribosomal protein L7a)	HGNC	OMA
Alliance orthologs ³
Homo sapiens (human):	DYNLRB1 (dynein light chain roadblock-type 1)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Dynlrb1 (dynein light chain roadblock-type 1)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	dynlrb1 (dynein, light chain, roadblock-type 1)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	dynlrb1 (dynein, light chain, roadblock-type 1)	Alliance	DIOPT (Ensembl Compara\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	dyrb-1	Alliance	DIOPT (Ensembl Compara\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	dyrb-1	Alliance	DIOPT (Ensembl Compara\|InParanoid\|OMA\|OrthoInspector\|PANTHER\|SonicParanoid)
Drosophila melanogaster (fruit fly):	robl	Alliance	DIOPT (Ensembl Compara\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|SonicParanoid)
Drosophila melanogaster (fruit fly):	robl	Alliance	DIOPT (Ensembl Compara\|OMA\|OrthoFinder)
Drosophila melanogaster (fruit fly):	robl22E	Alliance	DIOPT (OrthoFinder\|PANTHER\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	dynlrb1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB)
Xenopus tropicalis (tropical clawed frog):	dynlrb1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	3	164,197,892 - 164,224,409 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	3	164,202,953 - 164,224,409 (+)	Ensembl				GRCr8
mRatBN7.2	3	143,742,427 - 143,764,227 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	3	143,742,586 - 143,764,227 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	3	147,609,132 - 147,630,292 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	3	156,226,410 - 156,247,571 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	3	153,965,953 - 153,987,108 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	3	150,761,329 - 150,782,493 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	3	150,761,329 - 150,782,493 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	3	157,129,655 - 157,150,710 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	3	145,718,890 - 145,740,187 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	3	142,470,841 - 142,491,890 (+)	NCBI		Celera
RGSC_v3.1	3	145,624,519 - 145,645,809 (+)	NCBI
Cytogenetic Map	3	q41	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

hepatocellular carcinoma (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,2-dimethylhydrazine (ISO)

17beta-estradiol (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

3-phenylprop-2-enal (ISO)

4,4'-diaminodiphenylmethane (ISO)

4,4'-sulfonyldiphenol (EXP,ISO)

acrylamide (EXP)

actinomycin D (ISO)

aflatoxin B1 (EXP)

Aflatoxin B2 alpha (ISO)

ammonium chloride (EXP)

arsenite(3-) (ISO)

benzo[a]pyrene (EXP,ISO)

beta-lapachone (ISO)

beta-naphthoflavone (ISO)

bis(2-ethylhexyl) phthalate (ISO)

bisphenol A (EXP,ISO)

bisphenol F (EXP,ISO)

Brodifacoum (EXP)

CGP 52608 (ISO)

chlorpyrifos (ISO)

clofibrate (ISO)

cyclosporin A (ISO)

diallyl trisulfide (ISO)

Dibutyl phosphate (ISO)

dicrotophos (ISO)

elemental selenium (ISO)

epoxiconazole (ISO)

fenthion (ISO)

flavonoids (EXP)

flutamide (EXP)

hydrogen peroxide (ISO)

lithium atom (EXP)

lithium hydride (EXP)

methidathion (ISO)

nitrates (ISO)

Nutlin-3 (ISO)

paracetamol (ISO)

pirinixic acid (ISO)

progesterone (ISO)

resveratrol (ISO)

selenium atom (ISO)

sodium fluoride (ISO)

temozolomide (ISO)

tert-butyl hydroperoxide (ISO)

triptonide (ISO)

valproic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

microtubule-based movement (IBA,IEA)

response to light stimulus (IEP)

retrograde axonal transport (NAS)

visual behavior (IDA)

Cellular Component

axon cytoplasm (IEA)

centrosome (IBA,ISO)

cytoplasm (IBA,IDA)

cytoplasmic dynein complex (IBA,IEA,ISO,ISS)

cytoskeleton (IEA)

dynein complex (IEA)

microtubule (IEA)

Molecular Function

dynein intermediate chain binding (IBA)

identical protein binding (ISO)

protein binding (ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

mitochondria transport pathway (ISO)

transforming growth factor-beta Smad dependent signaling pathway (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Cytoplasmic dynein.	Allan VJ, Biochem Soc Trans. 2011 Oct;39(5):1169-78. doi: 10.1042/BST0391169.
2.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3.	Identification of two novel human dynein light chain genes, DNLC2A and DNLC2B, and their expression changes in hepatocellular carcinoma tissues from 68 Chinese patients.	Jiang J, etal., Gene. 2001 Dec 27;281(1-2):103-13.
4.	Electronic Transfer of LocusLink and RefSeq Data	NCBI rat LocusLink and RefSeq merged data July 26, 2002
5.	PID Annotation Import Pipeline	Pipeline to import Pathway Interaction Database annotations from NCI into RGD
6.	GOA pipeline	RGD automated data pipeline
7.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
8.	Comprehensive gene review and curation	RGD comprehensive gene curation
9.	Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.	Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
10.	Light-induced down-regulation of the rat class 1 dynein-associated protein robl/LC7-like gene in visual cortex.	Ye F, etal., J Biol Chem 2000 Sep 1;275(35):27172-6.

Additional References at PubMed

PMID:14752807	PMID:15489334	PMID:19946888	PMID:21399614	PMID:22871113	PMID:26272270	PMID:35352799

Genomics

Comparative Map Data

Dynlrb1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	3	164,197,892 - 164,224,409 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	3	164,202,953 - 164,224,409 (+)	Ensembl				GRCr8
mRatBN7.2	3	143,742,427 - 143,764,227 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	3	143,742,586 - 143,764,227 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	3	147,609,132 - 147,630,292 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	3	156,226,410 - 156,247,571 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	3	153,965,953 - 153,987,108 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	3	150,761,329 - 150,782,493 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	3	150,761,329 - 150,782,493 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	3	157,129,655 - 157,150,710 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	3	145,718,890 - 145,740,187 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	3	142,470,841 - 142,491,890 (+)	NCBI		Celera
RGSC_v3.1	3	145,624,519 - 145,645,809 (+)	NCBI
Cytogenetic Map	3	q41	NCBI

DYNLRB1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	20	34,515,602 - 34,540,958 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	20	34,516,379 - 34,540,958 (+)	Ensembl			hg38	GRCh38
GRCh37	20	33,103,407 - 33,128,762 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	20	32,567,865 - 32,592,423 (+)	NCBI	Build 36	Build 36	hg18	NCBI36
Build 34	20	32,567,864 - 32,592,422	NCBI
Celera	20	29,853,678 - 29,877,913 (+)	NCBI		Celera
Cytogenetic Map	20	q11.22	NCBI
HuRef	20	29,885,141 - 29,909,381 (+)	NCBI		HuRef
CHM1_1	20	33,005,407 - 33,029,599 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	20	36,238,779 - 36,264,135 (+)	NCBI		T2T-CHM13v2.0

Dynlrb1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	2	155,078,453 - 155,092,197 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	2	155,078,453 - 155,092,197 (+)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	2	155,236,533 - 155,250,277 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	2	155,236,533 - 155,250,277 (+)	Ensembl			mm10	GRCm38
MGSCv37	2	155,062,269 - 155,076,013 (+)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	2	154,928,013 - 154,941,714 (+)	NCBI		MGSCv36	mm8
Celera	2	161,168,778 - 161,182,651 (+)	NCBI		Celera
Cytogenetic Map	2	H1	NCBI
cM Map	2	77.07	NCBI

Dynlrb1
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955422	26,787,699 - 26,807,901 (-)	Ensembl
ChiLan1.0	NW_004955422	26,787,879 - 26,807,901 (-)	NCBI	ChiLan1.0	ChiLan1.0

DYNLRB1
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	21	40,248,384 - 40,274,192 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	20	40,242,989 - 40,267,295 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	20	30,845,447 - 30,869,776 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	20	31,976,943 - 32,001,199 (+)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	20	31,976,941 - 32,001,199 (+)	Ensembl			panPan2	panpan1.1

DYNLRB1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	24	23,633,580 - 23,653,273 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	24	23,633,579 - 23,673,921 (+)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	24	23,279,355 - 23,299,011 (+)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	24	24,324,114 - 24,343,784 (+)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	24	24,323,853 - 24,364,441 (+)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	24	23,611,632 - 23,631,299 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	24	23,706,715 - 23,726,388 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	24	24,145,608 - 24,165,309 (+)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Dynlrb1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024408640	172,614,488 - 172,630,700 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936561	6,119,190 - 6,123,653 (-)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936561	6,118,849 - 6,135,001 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

DYNLRB1
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	17	37,923,475 - 37,945,880 (+)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	17	37,923,451 - 37,941,851 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	17	43,121,861 - 43,139,869 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

DYNLRB1
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	2	38,813,852 - 38,839,905 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	2	38,825,574 - 38,839,903 (+)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666050	87,991,707 - 88,018,052 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Dynlrb1
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624842	4,817,469 - 4,837,824 (-)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624842	4,817,469 - 4,837,843 (-)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Dynlrb1
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	5	134,593,003 - 134,614,100 (+)	NCBI		Rrattus_CSIRO_v1

Variants

Variants in Dynlrb1
566 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	39
Count of miRNA genes:	35
Interacting mature miRNAs:	39
Transcripts:	ENSRNOT00000067854
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
12879876	Bw182	Body weight QTL 182		0.003	body mass (VT:0001259)	body weight (CMO:0000012)	3	141555229	186555229	Rat
2301411	Bp320	Blood pressure QTL 320		0.001	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	3	141555229	186555229	Rat
1582233	Insul10	Insulin level QTL 10	5.4	0.0015	blood insulin amount (VT:0001560)	serum insulin level times blood glucose level (CMO:0002040)	3	133259579	178259579	Rat
12879872	Cm97	Cardiac mass QTL 97		0.001	heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	3	141555229	186555229	Rat
12879873	Cm96	Cardiac mass QTL 96		0.001	heart mass (VT:0007028)	heart wet weight to body weight ratio (CMO:0002408)	3	141555229	186555229	Rat
1578653	Vnigr3	Vascular neointimal growth QTL 3	3.1		artery morphology trait (VT:0002191)	artery neointimal hyperplastic lesion area (CMO:0001414)	3	151075912	189428310	Rat
2302373	Gluco39	Glucose level QTL 39	5.01		blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	3	129154923	182114333	Rat
12879874	Cm98	Cardiac mass QTL 98		0.005	heart right ventricle mass (VT:0007033)	heart right ventricle weight to body weight ratio (CMO:0000914)	3	141555229	186555229	Rat
12879875	Kidm64	Kidney mass QTL 64		0.001	kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	3	141555229	186555229	Rat
1298068	Bp167	Blood pressure QTL 167		0.004	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	3	161492708	189428310	Rat
70216	Cm14	Cardiac mass QTL 14	2.1		heart mass (VT:0007028)	heart wet weight (CMO:0000069)	3	51581665	184004958	Rat
2292591	Esta4	Estrogen-induced thymic atrophy QTL 4			thymus mass (VT:0004954)	thymus wet weight (CMO:0000855)	3	67641776	167835660	Rat
61335	Bp20	Blood pressure QTL 20	3		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	3	161799493	176036425	Rat
1578754	Stresp16	Stress response QTL 16	4	0.001	blood renin amount (VT:0003349)	plasma renin activity level (CMO:0000116)	3	133134628	178134628	Rat
1331726	Bp208	Blood pressure QTL 208	3.129		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	3	161799270	187311134	Rat
1582213	Insul6	Insulin level QTL 6	3.7	0.0009	blood insulin amount (VT:0001560)	calculated serum insulin level (CMO:0000359)	3	155759447	189428310	Rat
1300173	Rf11	Renal function QTL 11	3.38		renal blood flow trait (VT:2000006)	absolute change in renal blood flow rate (CMO:0001168)	3	141508991	166376254	Rat
9589106	Insul23	Insulin level QTL 23	13.86	0.001	blood insulin amount (VT:0001560)	plasma insulin level (CMO:0000342)	3	152055202	189428310	Rat
10755461	Coatc16	Coat color QTL 16			coat/hair pigmentation trait (VT:0010463)	pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)	3	142898802	187898802	Rat
8662816	Vetf4	Vascular elastic tissue fragility QTL 4	4		renal artery integrity trait (VT:0010642)	number of ruptures of the internal elastic lamina of the renal arteries (CMO:0002563)	3	79649560	177741895	Rat
1559282	Emca5	Estrogen-induced mammary cancer QTL 5	3.9		mammary gland integrity trait (VT:0010552)	percentage of study population developing mammary tumors during a period of time (CMO:0000948)	3	145335553	189428310	Rat
2303620	Vencon4	Ventilatory control QTL 4	3.9		respiration trait (VT:0001943)	tidal volume (CMO:0000222)	3	125116475	170116475	Rat
1582256	Insul9	Insulin level QTL 9	4.4	0.0016	blood insulin amount (VT:0001560)	absolute change in serum insulin level (CMO:0002038)	3	155759447	189428310	Rat
1576306	Schws3	Schwannoma susceptibility QTL 3		0.001	nervous system integrity trait (VT:0010566)	percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)	3	139299381	184299381	Rat
5686842	Rf59	Renal function QTL 59			urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	3	122395989	167395989	Rat
1300159	Kidm4	Kidney mass QTL 4	3.83		kidney mass (VT:0002707)	right kidney wet weight to body weight ratio (CMO:0001953)	3	141508991	177728348	Rat
2301971	Cm71	Cardiac mass QTL 71	4.63		heart left ventricle mass (VT:0007031)	heart left ventricle weight (CMO:0000776)	3	131036586	176036586	Rat
631673	Iddm13	Insulin dependent diabetes mellitus QTL 13	1.3	0.663	blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	3	137114333	182114333	Rat
1582248	Insul7	Insulin level QTL 7	3.9	0.0041	blood insulin amount (VT:0001560)	calculated serum insulin level (CMO:0000359)	3	155759447	189428310	Rat
2301970	Bw81	Body weight QTL 81	5.19		body mass (VT:0001259)	body weight (CMO:0000012)	3	131036586	176036586	Rat
1581546	Pur13	Proteinuria QTL 13	2.93	0.0335	urine total protein amount (VT:0000032)	urine protein excretion rate (CMO:0000759)	3	98651826	167012663	Rat
1578666	Vnigr1	Vascular neointimal growth QTL 1	4.6		artery morphology trait (VT:0002191)	artery lumen area (CMO:0001409)	3	151075912	189428310	Rat
1578656	Vnigr2	Vascular neointimal growth QTL 2	4.2		artery morphology trait (VT:0002191)	lesioned artery residual lumen area (CMO:0001417)	3	151075912	189428310	Rat
12879871	Am7	Aortic mass QTL 7		0.001	aorta mass (VT:0002845)	aorta weight to aorta length to body weight ratio (CMO:0002722)	3	141555229	186555229	Rat
631541	Bp81	Blood pressure QTL 81	4		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	3	144575244	189428310	Rat
2293087	Iddm27	Insulin dependent diabetes mellitus QTL 27	2.68		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	3	160357340	167835660	Rat

Markers in Region

RH141051

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	3	143,763,911 - 143,764,119 (+)	MAPPER	mRatBN7.2
Rnor_6.0	3	150,782,179 - 150,782,386	NCBI	Rnor6.0
Rnor_5.0	3	157,150,396 - 157,150,603	UniSTS	Rnor5.0
RGSC_v3.4	3	145,739,873 - 145,740,080	UniSTS	RGSC3.4
Celera	3	142,491,576 - 142,491,783	UniSTS
RH 3.4 Map	3	1303.2	UniSTS
Cytogenetic Map	3	q42	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
16	12	67	165	91	90	59	92	59	6	356	192	11	144	81	92	31	17	17

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_131910	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039104174	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063283030	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC140696	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AF073839	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AY026512	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC058437	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH474050	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FM080737	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FM084891	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000003	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000067854 ⟹ ENSRNOP00000060800

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	3	164,203,548 - 164,224,409 (+)	Ensembl
mRatBN7.2 Ensembl	3	143,743,276 - 143,764,227 (+)	Ensembl
Rnor_6.0 Ensembl	3	150,761,329 - 150,782,493 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000105966 ⟹ ENSRNOP00000081755

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	3	143,752,948 - 143,763,290 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000106591 ⟹ ENSRNOP00000085894

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	3	164,202,953 - 164,224,409 (+)	Ensembl
mRatBN7.2 Ensembl	3	143,742,586 - 143,764,227 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000107177 ⟹ ENSRNOP00000085034

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	3	143,742,952 - 143,763,290 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000122357 ⟹ ENSRNOP00000110838

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	3	164,203,239 - 164,224,409 (+)	Ensembl

RefSeq Acc Id:

NM_131910 ⟹ NP_571985

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	3	164,203,239 - 164,224,409 (+)	NCBI
mRatBN7.2	3	143,743,053 - 143,764,227 (+)	NCBI
Rnor_6.0	3	150,761,329 - 150,782,493 (+)	NCBI
Rnor_5.0	3	157,129,655 - 157,150,710 (+)	NCBI
RGSC_v3.4	3	145,718,890 - 145,740,187 (+)	RGD
Celera	3	142,470,841 - 142,491,890 (+)	RGD

Sequence:

show sequence

GAAGAAACCCTGACAAGGACACAACGTGAGCAGGTGCTTTGGGCGTCAGGCCTCGTGCCGAATT
CGGCACGAGACTCGGCTGAGTGTTGGCGATTCGGAGCTGCTGTGTCTGTCCGAGATGGCAGAGG
TGGAGGAAACACTCAAGAGGCTTCAGAGCCAGAAAGGAGTGCAGGGCATCATCGTGGTGAACAC
AGAAGGCATTCCCATCAAGAGCACAATGGACAATCCCACCACGACACAGTACGCCAACCTCATG
CACAACTTCATCTTAAAGGCTCGGAGCACTGTGCGTGAGATTGACCCCCAGAATGACCTAACCT
TCCTTCGAATTCGCTCCAAGAAAAATGAAATTATGGTGGCACCAGATAAAGACTATTTCCTGAT
TGTGATTCAGAATCCAACTGAATAAGGCACTGTCTTGGCTTCCTGTGTCATTCCTTAATTTAAC
GTCCCCCGAGAATAATAGCGTTAATCATGTCAGTGGGCACATGTGGCTGCCTGGAGCCATGCAG
ACCTTGGCATTGGTGAAGGGCAGCTCTGCCCACCCCACCAAGGAGTGCCTCTGATGATCCGGTC
AGTCCCCAGAAGAGCTCAGTTCTCTCTCCAGGCTTTGGAATGAGAGCTCTTGATGAGCCCACAG
CCAGCTTCCTTCTAACCTTCATTTCACTTTGTCCCCCTTGGAAGCTGTTTTTGTTTTTTTAAAC
TAAAAATAACTTCAACCCCAAAAAAAAAAAAAAAAAAA

hide sequence

RefSeq Acc Id:

XM_039104174 ⟹ XP_038960102

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	3	164,199,171 - 164,224,409 (+)	NCBI
mRatBN7.2	3	143,742,427 - 143,764,227 (+)	NCBI

RefSeq Acc Id:

XM_063283030 ⟹ XP_063139100

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	3	164,197,892 - 164,224,409 (+)	NCBI

Protein Sequences


Protein RefSeqs	NP_571985	(Get FASTA)	NCBI Sequence Viewer
	XP_038960102	(Get FASTA)	NCBI Sequence Viewer
	XP_063139100	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAC25580	(Get FASTA)	NCBI Sequence Viewer
	AAH58437	(Get FASTA)	NCBI Sequence Viewer
	AAK18711	(Get FASTA)	NCBI Sequence Viewer
	EDL85932	(Get FASTA)	NCBI Sequence Viewer
	EDL85933	(Get FASTA)	NCBI Sequence Viewer
	EDL85934	(Get FASTA)	NCBI Sequence Viewer
	EDL85935	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000085894
	ENSRNOP00000110838
GenBank Protein	P62628	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:	NP_571985 ⟸ NM_131910
- UniProtKB:	P62628 (UniProtKB/Swiss-Prot), A6KI20 (UniProtKB/TrEMBL), A0A8I6A1D3 (UniProtKB/TrEMBL)
- Sequence:	show sequence MAEVEETLKRLQSQKGVQGIIVVNTEGIPIKSTMDNPTTTQYANLMHNFILKARSTVREIDPQN DLTFLRIRSKKNEIMVAPDKDYFLIVIQNPTE hide sequence

Ensembl Acc Id:

ENSRNOP00000060800 ⟸ ENSRNOT00000067854

RefSeq Acc Id:	XP_038960102 ⟸ XM_039104174
- Peptide Label:	isoform X2

Ensembl Acc Id:

ENSRNOP00000085034 ⟸ ENSRNOT00000107177

Ensembl Acc Id:

ENSRNOP00000085894 ⟸ ENSRNOT00000106591

Ensembl Acc Id:

ENSRNOP00000081755 ⟸ ENSRNOT00000105966

RefSeq Acc Id:	XP_063139100 ⟸ XM_063283030
- Peptide Label:	isoform X1
- UniProtKB:	A0A8I6A2M7 (UniProtKB/TrEMBL)

Ensembl Acc Id:

ENSRNOP00000110838 ⟸ ENSRNOT00000122357

Protein Domains

Roadblock/LAMTOR2

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-P62628-F1-model_v2	AlphaFold	P62628	1-96	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13692580

Promoter ID:

EPDNEW_R3105

Type:

initiation region

Name:

Dynlrb1_1

Description:

dynein light chain roadblock-type 1

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	3	150,761,324 - 150,761,384	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:619910	AgrOrtholog
BioCyc Gene	G2FUF-47147	BioCyc
Ensembl Genes	ENSRNOG00000025715	Ensembl, ENTREZGENE
Ensembl Transcript	ENSRNOT00000106591	ENTREZGENE
	ENSRNOT00000122357	ENTREZGENE
Gene3D-CATH	Dynein light chain 2a, cytoplasmic	UniProtKB/Swiss-Prot
IMAGE_CLONE	IMAGE:6921076	IMAGE-MGC_LOAD
InterPro	DYNLRB1/2	UniProtKB/Swiss-Prot
	Roadblock/LAMTOR2_dom	UniProtKB/Swiss-Prot
KEGG Report	rno:170714	UniProtKB/Swiss-Prot
MGC_CLONE	MGC:72642	IMAGE-MGC_LOAD
NCBI Gene	170714	ENTREZGENE
PANTHER	DYNEIN LIGHT CHAIN ROADBLOCK	UniProtKB/Swiss-Prot
Pfam	Robl_LC7	UniProtKB/Swiss-Prot
PhenoGen	Dynlrb1	PhenoGen
PIRSF	DLC7	UniProtKB/Swiss-Prot
RatGTEx	ENSRNOG00000025715	RatGTEx
SMART	Robl_LC7	UniProtKB/Swiss-Prot
Superfamily-SCOP	Roadblock/LC7 domain	UniProtKB/Swiss-Prot
UniProt	A0A8I6A1D3	ENTREZGENE
	A0A8I6A2M7	ENTREZGENE, UniProtKB/TrEMBL
	A0A8L2QTT3_RAT	UniProtKB/TrEMBL
	A6KI20	ENTREZGENE, UniProtKB/TrEMBL
	DLRB1_RAT	UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary	O88567	UniProtKB/Swiss-Prot
	Q9D812	UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2008-02-22	Dynlrb1	dynein light chain roadblock-type 1	Dncl2a	dynein, cytoplasmic, light chain 2A	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2005-01-20	Dncl2a	dynein, cytoplasmic, light chain 2A	km23	dynein-associated protein RKM23	Symbol and Name updated	1299863	APPROVED
2002-08-07	km23	dynein-associated protein RKM23			Symbol and Name status set to provisional	70820	PROVISIONAL

RGD Curation Notes

Note Type	Note	Reference
gene_expression	expressed in the neocortex	633064
gene_process	involved in synaptic stimulation	633064
gene_regulation	sensory stimulation down regulates the activity	633064

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

RGD Manual Annotations

Imported Annotations - PID (archival)

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RGD Manual Annotations

Imported Annotations - PID (archival)