Epn1 (Epsin 1) - Rat Genome Database

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Gene: Epn1 (Epsin 1) Rattus norvegicus
Analyze
Symbol: Epn1
Name: Epsin 1
RGD ID: 619772
Description: Enables clathrin adaptor activity and transmembrane transporter binding activity. Involved in several processes, including clathrin coat assembly; membrane fission; and positive regulation of clathrin coat assembly. Located in cytosol; postsynaptic membrane; and presynaptic membrane. Is active in Schaffer collateral - CA1 synapse and postsynapse. Biomarker of middle cerebral artery infarction. Orthologous to human EPN1 (epsin 1); PARTICIPATES IN clathrin-dependent synaptic vesicle endocytosis; endocytosis pathway; INTERACTS WITH 2,2',4,4'-Tetrabromodiphenyl ether; 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: EPS-15-interacting protein 1; epsin-1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8177,771,335 - 77,789,411 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl177,771,335 - 77,789,411 (-)EnsemblGRCr8
mRatBN7.2168,742,491 - 68,760,570 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl168,742,789 - 68,758,874 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx174,087,576 - 74,105,651 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0182,651,885 - 82,669,960 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0175,800,539 - 75,818,619 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0172,294,153 - 72,310,217 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl172,294,153 - 72,311,856 (-)Ensemblrn6Rnor6.0
Rnor_5.0176,226,173 - 76,242,237 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4167,479,998 - 67,496,066 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera168,360,140 - 68,376,208 (+)NCBICelera
RGSC_v3.1167,558,113 - 67,574,177 (-)NCBI
Cytogenetic Map1q12NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Epsin N-terminal homology domains perform an essential function regulating Cdc42 through binding Cdc42 GTPase-activating proteins. Aguilar RC, etal., Proc Natl Acad Sci U S A. 2006 Mar 14;103(11):4116-21. Epub 2006 Mar 6.
2. Accessory protein recruitment motifs in clathrin-mediated endocytosis. Brett TJ, etal., Structure. 2002 Jun;10(6):797-809.
3. Single particle fluorescence burst analysis of epsin induced membrane fission. Brooks A, etal., PLoS One. 2015 Mar 23;10(3):e0119563. doi: 10.1371/journal.pone.0119563. eCollection 2015.
4. Epsin is an EH-domain-binding protein implicated in clathrin-mediated endocytosis. Chen H, etal., Nature 1998 Aug 20;394(6695):793-7.
5. Epsin binds to clathrin by associating directly with the clathrin-terminal domain. Evidence for cooperative binding through two discrete sites. Drake MT, etal., J Biol Chem. 2000 Mar 3;275(9):6479-89.
6. Curvature of clathrin-coated pits driven by epsin. Ford MG, etal., Nature 2002 Sep 26;419(6905):361-6.
7. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
8. Epsin 1 undergoes nucleocytosolic shuttling and its eps15 interactor NH(2)-terminal homology (ENTH) domain, structurally similar to Armadillo and HEAT repeats, interacts with the transcription factor promyelocytic leukemia Zn(2)+ finger protein (PLZF). Hyman J, etal., J Cell Biol. 2000 May 1;149(3):537-46.
9. Unusual structural organization of the endocytic proteins AP180 and epsin 1. Kalthoff C, etal., J Biol Chem. 2002 Mar 8;277(10):8209-16. Epub 2001 Dec 26.
10. Deletion of a conserved noncoding sequence in Plzf intron leads to Plzf down-regulation in limb bud and polydactyly in the rat. Liska F, etal., Dev Dyn. 2009 Mar;238(3):673-84.
11. Notch ligand endocytosis generates mechanical pulling force dependent on dynamin, epsins, and actin. Meloty-Kapella L, etal., Dev Cell. 2012 Jun 12;22(6):1299-312. doi: 10.1016/j.devcel.2012.04.005. Epub 2012 May 31.
12. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
13. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
14. Purification of an EH domain-binding protein from rat brain that modulates the gating of the rat ether-a-go-go channel. Piros ET, etal., J Biol Chem. 1999 Nov 19;274(47):33677-83.
15. GOA pipeline RGD automated data pipeline
16. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
17. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
18. The NECAP PHear domain increases clathrin accessory protein binding potential. Ritter B, etal., EMBO J. 2007 Sep 19;26(18):4066-77. Epub 2007 Aug 30.
19. The epsins define a family of proteins that interact with components of the clathrin coat and contain a new protein module. Rosenthal JA, etal., J Biol Chem 1999 Nov 26;274(48):33959-65.
20. Calpain hydrolysis of alpha- and beta2-adaptins decreases clathrin-dependent endocytosis and may promote neurodegeneration. Rudinskiy N, etal., J Biol Chem. 2009 May 1;284(18):12447-58. doi: 10.1074/jbc.M804740200. Epub 2009 Feb 24.
21. Synaptic vesicle endocytosis. Saheki Y and De Camilli P, Cold Spring Harb Perspect Biol. 2012 Sep 1;4(9):a005645. doi: 10.1101/cshperspect.a005645.
22. Crystal structure of the alpha appendage of AP-2 reveals a recruitment platform for clathrin-coat assembly. Traub LM, etal., Proc Natl Acad Sci U S A. 1999 Aug 3;96(16):8907-12.
23. Composition of isolated synaptic boutons reveals the amounts of vesicle trafficking proteins. Wilhelm BG, etal., Science. 2014 May 30;344(6187):1023-8. doi: 10.1126/science.1252884.
24. Partially overlapping distribution of epsin1 and HIP1 at the synapse: analysis by immunoelectron microscopy. Yao PJ, etal., J Comp Neurol. 2006 Jan 10;494(2):368-79.
Additional References at PubMed
PMID:9920862   PMID:11161217   PMID:11382783   PMID:11919637   PMID:12234931   PMID:12750376   PMID:14657369   PMID:16885233   PMID:16903783   PMID:19536136   PMID:19666558   PMID:20366178  
PMID:22871113   PMID:25837255   PMID:28717225   PMID:29476059   PMID:32337703  


Genomics

Comparative Map Data
Epn1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8177,771,335 - 77,789,411 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl177,771,335 - 77,789,411 (-)EnsemblGRCr8
mRatBN7.2168,742,491 - 68,760,570 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl168,742,789 - 68,758,874 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx174,087,576 - 74,105,651 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0182,651,885 - 82,669,960 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0175,800,539 - 75,818,619 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0172,294,153 - 72,310,217 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl172,294,153 - 72,311,856 (-)Ensemblrn6Rnor6.0
Rnor_5.0176,226,173 - 76,242,237 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4167,479,998 - 67,496,066 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera168,360,140 - 68,376,208 (+)NCBICelera
RGSC_v3.1167,558,113 - 67,574,177 (-)NCBI
Cytogenetic Map1q12NCBI
EPN1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381955,675,226 - 55,709,533 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1955,675,109 - 55,709,858 (+)Ensemblhg38GRCh38
GRCh371956,186,592 - 56,220,899 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361960,878,404 - 60,898,945 (+)NCBIBuild 36Build 36hg18NCBI36
Build 341960,878,403 - 60,898,944NCBI
Celera1953,228,855 - 53,249,427 (+)NCBICelera
Cytogenetic Map19q13.42NCBI
HuRef1952,497,593 - 52,517,630 (+)NCBIHuRef
CHM1_11956,180,226 - 56,200,825 (+)NCBICHM1_1
T2T-CHM13v2.01958,772,202 - 58,806,505 (+)NCBIT2T-CHM13v2.0
Epn1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3975,083,207 - 5,101,178 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl75,083,234 - 5,101,177 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm3875,080,137 - 5,098,179 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl75,080,235 - 5,098,178 (+)Ensemblmm10GRCm38
MGSCv3775,031,907 - 5,049,778 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv3674,683,392 - 4,701,263 (+)NCBIMGSCv36mm8
Celera74,822,389 - 4,840,262 (+)NCBICelera
Cytogenetic Map7A1NCBI
cM Map72.94NCBI
Epn1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955567669,685 - 682,852 (-)Ensembl
ChiLan1.0NW_004955567669,333 - 683,283 (-)NCBIChiLan1.0ChiLan1.0
EPN1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22061,816,561 - 61,837,862 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11963,546,588 - 63,567,706 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01952,722,107 - 52,743,321 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11961,408,678 - 61,428,058 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1961,408,695 - 61,427,647 (+)EnsemblpanPan2panpan1.1
EPN1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11102,059,022 - 102,073,665 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1102,059,181 - 102,073,561 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1102,116,113 - 102,130,802 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01102,712,494 - 102,727,183 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1102,712,496 - 102,727,223 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11102,350,090 - 102,364,779 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01102,061,977 - 102,076,667 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01102,825,037 - 102,839,725 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Epn1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244093491,684,602 - 1,703,390 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936981194,157 - 213,066 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_004936981194,176 - 213,021 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
EPN1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl659,789,946 - 59,802,299 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1659,789,952 - 59,802,302 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2654,762,216 - 54,768,439 (-)NCBISscrofa10.2Sscrofa10.2susScr3
EPN1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1648,265,498 - 48,287,817 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl648,267,365 - 48,288,296 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_023666045922,638 - 944,920 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Epn1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248321,732,571 - 1,746,888 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046248321,732,895 - 1,746,963 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Epn1
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v12177,658,743 - 177,676,781 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Epn1
206 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:62
Count of miRNA genes:56
Interacting mature miRNAs:61
Transcripts:ENSRNOT00000021286
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1331732Srn4Serum renin concentration QTL 44.467renin activity (VT:0005581)plasma renin activity level (CMO:0000116)14345783787558729Rat
1578649Bmd8Bone mineral density QTL 84.9femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)151940904101229020Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)151941022208479811Rat
1358359Sradr1Stress Responsive Adrenal Weight QTL 14.74adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)139728272132889942Rat
4889929Bss87Bone structure and strength QTL 876.7tibia area (VT:1000281)tibia-fibula cortical bone endosteal cross-sectional area (CMO:0001722)14630261591302615Rat
1331792Rf29Renal function QTL 294.589urine potassium amount (VT:0010539)urine potassium level (CMO:0000128)14345783787558729Rat
2313062Bmd73Bone mineral density QTL 733.90.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)14630261591302615Rat
1578654Bss10Bone structure and strength QTL 104femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)151940904168768703Rat
8552900Pigfal1Plasma insulin-like growth factor 1 level QTL 17.4blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)14350995288509952Rat
1354643Foco2Food consumption QTL 27.170.0001eating behavior trait (VT:0001431)food intake rate (CMO:0000427)14212296887122968Rat
2313065Bss67Bone structure and strength QTL 673.10.0001tibia area (VT:1000281)tibia total energy absorbed before break (CMO:0001736)14630261591302615Rat
631495Bp96Blood pressure QTL 964.52arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)166404680111404680Rat
2313069Bss68Bone structure and strength QTL 682.90.0001tibia size trait (VT:0100001)tibia total energy absorbed before break (CMO:0001736)14630261591302615Rat
70225Bp58Blood pressure QTL 583.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134184556172281316Rat
2313075Bss66Bone structure and strength QTL 663.40.0001tibia length (VT:0004357)tibia length (CMO:0000450)14630261591302615Rat
2298545Neuinf8Neuroinflammation QTL 84.6nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)166009857160501508Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134565911208798288Rat
1331778Rf28Renal function QTL 284.66urine potassium amount (VT:0010539)urine potassium excretion rate (CMO:0000761)14345783787558729Rat
2313077Bss69Bone structure and strength QTL 693.50.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)14630261591302615Rat
1302788Scl19Serum cholesterol QTL 194.60.001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)166400974132889942Rat
2313402Anxrr24Anxiety related response QTL 24aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)151511344153680016Rat
1331785Rf27Renal function QTL 274.643urine sodium amount (VT:0006274)urine sodium level (CMO:0000129)13070837587558729Rat
61342Bp27Blood pressure QTL 273.40.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)16540563796805205Rat
1300172Bp172Blood pressure QTL 1723.56arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)13456572679565726Rat
4889962Bss94Bone structure and strength QTL 943.8tibia area (VT:1000281)tibia-fibula cortical bone endosteal cross-sectional area (CMO:0001722)15190920691302615Rat
6903308Scl36Serum cholesterol QTL 3620.0125blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)158769992103769992Rat
2300164Bmd44Bone mineral density QTL 445.40.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)166077886111077886Rat
2313092Bmd72Bone mineral density QTL 722.50.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)14630261591302615Rat
2313097Bss70Bone structure and strength QTL 703.50.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)14630261591302615Rat
9589820Insglur3Insulin/glucose ratio QTL 310.750.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)14350995288509952Rat
152025249Scl82Serum cholesterol level QTL 824.77blood cholesterol amount (VT:0000180)152891222109116986Rat
1354599Bw29Body weight QTL 293.460.001body mass (VT:0001259)body weight (CMO:0000012)14212296887122968Rat
4889919Bss86Bone structure and strength QTL 864.1tibia area (VT:1000281)tibia midshaft total cross-sectional area (CMO:0001715)14630261591302615Rat
8552948Pigfal11Plasma insulin-like growth factor 1 level QTL 114.7blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)14350995288509952Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 162 91 90 59 92 59 6 356 192 11 141 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000021286   ⟹   ENSRNOP00000021286
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl177,771,335 - 77,789,411 (-)Ensembl
mRatBN7.2 Ensembl168,742,789 - 68,758,874 (-)Ensembl
Rnor_6.0 Ensembl172,294,153 - 72,311,856 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000119836   ⟹   ENSRNOP00000092218
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl177,771,335 - 77,789,411 (-)Ensembl
mRatBN7.2 Ensembl168,742,789 - 68,758,874 (-)Ensembl
RefSeq Acc Id: NM_057136   ⟹   NP_476477
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8177,771,335 - 77,789,411 (-)NCBI
mRatBN7.2168,742,491 - 68,760,570 (-)NCBI
Rnor_6.0172,294,153 - 72,310,217 (-)NCBI
Rnor_5.0176,226,173 - 76,242,237 (+)NCBI
RGSC_v3.4167,479,998 - 67,496,066 (-)RGD
Celera168,360,140 - 68,376,208 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_476477 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAC33823 (Get FASTA)   NCBI Sequence Viewer  
  EDL75887 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000021286
GenBank Protein O88339 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_476477   ⟸   NM_057136
- UniProtKB: O88339 (UniProtKB/Swiss-Prot),   A6KNR8 (UniProtKB/TrEMBL),   A0A140TAC3 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000021286   ⟸   ENSRNOT00000021286
Ensembl Acc Id: ENSRNOP00000092218   ⟸   ENSRNOT00000119836
Protein Domains
ENTH   UIM

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-O88339-F1-model_v2 AlphaFold O88339 1-575 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13689688
Promoter ID:EPDNEW_R212
Type:initiation region
Name:Epn1_1
Description:Epsin 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0172,311,945 - 72,312,005EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:619772 AgrOrtholog
BIND 144372
BioCyc Gene G2FUF-60884 BioCyc
Ensembl Genes ENSRNOG00000015753 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000021286 ENTREZGENE
Gene3D-CATH 1.25.40.90 UniProtKB/Swiss-Prot
InterPro ENTH UniProtKB/Swiss-Prot
  ENTH_VHS UniProtKB/Swiss-Prot
  UIM_dom UniProtKB/Swiss-Prot
KEGG Report rno:117277 UniProtKB/Swiss-Prot
NCBI Gene 117277 ENTREZGENE
PANTHER EPSIN-1 UniProtKB/Swiss-Prot
  EPSIN/ENT-RELATED UniProtKB/Swiss-Prot
Pfam ENTH UniProtKB/Swiss-Prot
PhenoGen Epn1 PhenoGen
PROSITE ENTH UniProtKB/Swiss-Prot
  UIM UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000015753 RatGTEx
SMART ENTH UniProtKB/Swiss-Prot
  UIM UniProtKB/Swiss-Prot
Superfamily-SCOP SSF48464 UniProtKB/Swiss-Prot
UniProt A0A140TAC3 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6GJL1_RAT UniProtKB/TrEMBL
  A6KNR8 ENTREZGENE, UniProtKB/TrEMBL
  EPN1_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-09-10 Epn1  Epsin 1      Symbol and Name status set to approved 1299863 APPROVED
2002-08-07 Epn1  Epsin 1      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_expression enriched in brain 632726