Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | (1->4)-beta-D-glucan | multiple interactions | ISO | Smpd2 (Mus musculus) | 6480464 | [perfluorooctane sulfonic acid co-treated with Cellulose] results in increased expression of SMPD2 mRNA | CTD | PMID:36331819 | (25R)-cholest-5-ene-3beta,26-diol | decreases activity | ISO | SMPD2 (Homo sapiens) | 6480464 | 27-hydroxycholesterol results in decreased activity of SMPD2 protein | CTD | PMID:15261762 | 1,2-dimethylhydrazine | increases expression | ISO | Smpd2 (Mus musculus) | 6480464 | 1 and 2-Dimethylhydrazine results in increased expression of SMPD2 mRNA | CTD | PMID:22206623 | 1,2-dimethylhydrazine | multiple interactions | ISO | Smpd2 (Mus musculus) | 6480464 | Folic Acid inhibits the reaction [1 and 2-Dimethylhydrazine results in increased expression of SMPD2 mRNA] | CTD | PMID:22206623 | 17beta-hydroxy-5alpha-androstan-3-one | increases expression | ISO | SMPD2 (Homo sapiens) | 6480464 | Dihydrotestosterone results in increased expression of SMPD2 mRNA | CTD | PMID:29581250 | 2,3,7,8-tetrachlorodibenzodioxine | multiple interactions | ISO | Smpd2 (Mus musculus) | 6480464 | [decitabine co-treated with Tetrachlorodibenzodioxin] results in decreased expression of SMPD2 mRNA | CTD | PMID:15251184 | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | EXP | | 6480464 | Tetrachlorodibenzodioxin results in increased expression of SMPD2 mRNA | CTD | PMID:33387578 | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | ISO | Smpd2 (Mus musculus) | 6480464 | Tetrachlorodibenzodioxin affects the expression of SMPD2 mRNA | CTD | PMID:21570461 | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | ISO | Smpd2 (Mus musculus) | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of SMPD2 mRNA | CTD | PMID:15251184 and PMID:19770486 | 2,3,7,8-Tetrachlorodibenzofuran | increases expression | ISO | Smpd2 (Mus musculus) | 6480464 | 2 more ... | CTD | PMID:34097992 | 2,3,7,8-Tetrachlorodibenzofuran | multiple interactions | ISO | Smpd2 (Mus musculus) | 6480464 | AHR gene mutant form inhibits the reaction [2 more ... | CTD | PMID:34097992 | 2,4-dinitrotoluene | affects expression | EXP | | 6480464 | 2 and 4-dinitrotoluene affects the expression of SMPD2 mRNA | CTD | PMID:21346803 | 2,6-dinitrotoluene | affects expression | EXP | | 6480464 | 2 and 6-dinitrotoluene affects the expression of SMPD2 mRNA | CTD | PMID:21346803 | 26-hydroxycholesterol | decreases activity | ISO | SMPD2 (Homo sapiens) | 6480464 | 27-hydroxycholesterol results in decreased activity of SMPD2 protein | CTD | PMID:15261762 | 3,3',4,4'-tetrachlorobiphenyl | multiple interactions | ISO | Smpd2 (Mus musculus) | 6480464 | 3 more ... | CTD | PMID:19467301 | 5-aza-2'-deoxycytidine | multiple interactions | ISO | Smpd2 (Mus musculus) | 6480464 | [Decitabine co-treated with Tetrachlorodibenzodioxin] results in decreased expression of SMPD2 mRNA | CTD | PMID:15251184 | 5-aza-2'-deoxycytidine | decreases expression | ISO | Smpd2 (Mus musculus) | 6480464 | Decitabine results in decreased expression of SMPD2 mRNA | CTD | PMID:15251184 | 6-propyl-2-thiouracil | decreases expression | EXP | | 6480464 | Propylthiouracil results in decreased expression of SMPD2 mRNA | CTD | PMID:36843608 | acrylamide | increases expression | EXP | | 6480464 | Acrylamide results in increased expression of SMPD2 mRNA | CTD | PMID:28959563 | acrylamide | decreases expression | ISO | SMPD2 (Homo sapiens) | 6480464 | Acrylamide results in decreased expression of SMPD2 mRNA | CTD | PMID:32763439 | all-trans-retinoic acid | increases expression | ISO | SMPD2 (Homo sapiens) | 6480464 | Tretinoin results in increased expression of SMPD2 mRNA | CTD | PMID:33167477 | ammonium chloride | affects expression | EXP | | 6480464 | Ammonium Chloride affects the expression of SMPD2 mRNA | CTD | PMID:16483693 | ampicillin | multiple interactions | EXP | | 6480464 | [Ampicillin co-treated with Neomycin co-treated with Gentamicins co-treated with Metronidazole co-treated with Vancomycin] results in increased expression of SMPD2 protein | CTD | PMID:30545405 | antirheumatic drug | decreases expression | ISO | SMPD2 (Homo sapiens) | 6480464 | Antirheumatic Agents results in decreased expression of SMPD2 mRNA | CTD | PMID:24449571 | aristolochic acid A | decreases expression | ISO | SMPD2 (Homo sapiens) | 6480464 | aristolochic acid I results in decreased expression of SMPD2 mRNA | CTD | PMID:33212167 | benzo[a]pyrene | increases expression | EXP | | 6480464 | Benzo(a)pyrene results in increased expression of SMPD2 mRNA | CTD | PMID:21839799 | benzo[a]pyrene | decreases methylation | ISO | SMPD2 (Homo sapiens) | 6480464 | Benzo(a)pyrene results in decreased methylation of SMPD2 5' UTR | CTD | PMID:27901495 | benzo[a]pyrene | multiple interactions | ISO | Smpd2 (Mus musculus) | 6480464 | [Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of SMPD2 mRNA | CTD | PMID:27858113 | benzo[a]pyrene | decreases expression | EXP | | 6480464 | Benzo(a)pyrene results in decreased expression of SMPD2 mRNA | CTD | PMID:25490995 | benzo[a]pyrene | increases expression | ISO | Smpd2 (Mus musculus) | 6480464 | Benzo(a)pyrene results in increased expression of SMPD2 mRNA | CTD | PMID:22228805 | benzo[b]fluoranthene | multiple interactions | ISO | Smpd2 (Mus musculus) | 6480464 | [Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of SMPD2 mRNA | CTD | PMID:27858113 | bezafibrate | multiple interactions | EXP | | 6480464 | [Bezafibrate results in increased activity of PPARA protein] which results in decreased activity of SMPD2 protein | CTD | PMID:18024222 | bis(2-ethylhexyl) phthalate | decreases expression | ISO | Smpd2 (Mus musculus) | 6480464 | Diethylhexyl Phthalate results in decreased expression of SMPD2 mRNA | CTD | PMID:28085963 | bisphenol A | increases expression | EXP | | 6480464 | bisphenol A results in increased expression of SMPD2 mRNA | CTD | PMID:25181051 more ... | bisphenol A | decreases expression | EXP | | 6480464 | bisphenol A results in decreased expression of SMPD2 mRNA | CTD | PMID:34947998 | bisphenol A | increases expression | ISO | Smpd2 (Mus musculus) | 6480464 | bisphenol A results in increased expression of SMPD2 mRNA | CTD | PMID:33221593 | C60 fullerene | decreases expression | EXP | | 6480464 | fullerene C60 results in decreased expression of SMPD2 mRNA | CTD | PMID:19167457 | carmustine | increases expression | ISO | SMPD2 (Homo sapiens) | 6480464 | Carmustine results in increased expression of SMPD2 mRNA | CTD | PMID:15980968 | chrysene | multiple interactions | ISO | Smpd2 (Mus musculus) | 6480464 | [Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of SMPD2 mRNA | CTD | PMID:27858113 | cisplatin | multiple interactions | ISO | SMPD2 (Homo sapiens) | 6480464 | [Cisplatin co-treated with jinfukang] results in increased expression of SMPD2 mRNA | CTD | PMID:27392435 | clofibrate | decreases expression | ISO | Smpd2 (Mus musculus) | 6480464 | Clofibrate results in decreased expression of SMPD2 mRNA | CTD | PMID:17585979 | Cuprizon | decreases expression | EXP | | 6480464 | Cuprizone results in decreased expression of SMPD2 mRNA | CTD | PMID:26577399 | dexamethasone | increases expression | ISO | Smpd2 (Mus musculus) | 6480464 | Dexamethasone results in increased expression of SMPD2 mRNA | CTD | PMID:22733784 | dextran sulfate | decreases expression | ISO | Smpd2 (Mus musculus) | 6480464 | Dextran Sulfate results in decreased expression of SMPD2 mRNA | CTD | PMID:25035112 | dextran sulfate | multiple interactions | ISO | Smpd2 (Mus musculus) | 6480464 | Fenofibrate promotes the reaction [Dextran Sulfate results in decreased expression of SMPD2 mRNA] | CTD | PMID:25035112 | epoxiconazole | decreases expression | ISO | Smpd2 (Mus musculus) | 6480464 | epoxiconazole results in decreased expression of SMPD2 mRNA | CTD | PMID:35436446 | fenofibrate | multiple interactions | ISO | Smpd2 (Mus musculus) | 6480464 | Fenofibrate promotes the reaction [Dextran Sulfate results in decreased expression of SMPD2 mRNA] | CTD | PMID:25035112 | flavonoids | multiple interactions | EXP | | 6480464 | Flavonoids inhibits the reaction [Carbon Tetrachloride results in increased activity of SMPD2 protein] | CTD | PMID:18226198 | folic acid | multiple interactions | ISO | Smpd2 (Mus musculus) | 6480464 | Folic Acid inhibits the reaction [1 and 2-Dimethylhydrazine results in increased expression of SMPD2 mRNA] | CTD | PMID:22206623 | gentamycin | increases activity | EXP | | 6480464 | Gentamicins results in increased activity of SMPD2 protein | CTD | PMID:24798086 | gentamycin | multiple interactions | EXP | | 6480464 | [Ampicillin co-treated with Neomycin co-treated with Gentamicins co-treated with Metronidazole co-treated with Vancomycin] results in increased expression of SMPD2 protein | CTD | PMID:30545405 | gentamycin | increases expression | EXP | | 6480464 | Gentamicins results in increased expression of SMPD2 mRNA | CTD | PMID:22061828 and PMID:33387578 | inulin | multiple interactions | ISO | Smpd2 (Mus musculus) | 6480464 | [perfluorooctane sulfonic acid co-treated with Inulin] results in increased expression of SMPD2 mRNA | CTD | PMID:36331819 | metronidazole | multiple interactions | EXP | | 6480464 | [Ampicillin co-treated with Neomycin co-treated with Gentamicins co-treated with Metronidazole co-treated with Vancomycin] results in increased expression of SMPD2 protein | CTD | PMID:30545405 | NAD zwitterion | affects activity | ISO | SMPD2 (Homo sapiens) | 6480464 | NAD affects the activity of SMPD2 protein | CTD | PMID:20518072 | NAD(+) | affects activity | ISO | SMPD2 (Homo sapiens) | 6480464 | NAD affects the activity of SMPD2 protein | CTD | PMID:20518072 | neomycin | multiple interactions | EXP | | 6480464 | [Ampicillin co-treated with Neomycin co-treated with Gentamicins co-treated with Metronidazole co-treated with Vancomycin] results in increased expression of SMPD2 protein | CTD | PMID:30545405 | paracetamol | increases expression | EXP | | 6480464 | Acetaminophen results in increased expression of SMPD2 mRNA | CTD | PMID:33387578 | paraquat | increases expression | ISO | Smpd2 (Mus musculus) | 6480464 | Paraquat results in increased expression of SMPD2 mRNA | CTD | PMID:36108500 | perfluorononanoic acid | decreases expression | ISO | SMPD2 (Homo sapiens) | 6480464 | perfluoro-n-nonanoic acid results in decreased expression of SMPD2 mRNA | CTD | PMID:25812627 | perfluorooctane-1-sulfonic acid | multiple interactions | ISO | Smpd2 (Mus musculus) | 6480464 | [perfluorooctane sulfonic acid co-treated with Cellulose] results in increased expression of SMPD2 mRNA more ... | CTD | PMID:36331819 | perfluorooctane-1-sulfonic acid | decreases expression | ISO | SMPD2 (Homo sapiens) | 6480464 | perfluorooctane sulfonic acid results in decreased expression of SMPD2 mRNA | CTD | PMID:25812627 | perfluorooctanoic acid | decreases expression | ISO | SMPD2 (Homo sapiens) | 6480464 | perfluorooctanoic acid results in decreased expression of SMPD2 mRNA | CTD | PMID:25812627 | phenobarbital | multiple interactions | ISO | Smpd2 (Mus musculus) | 6480464 | NR1I3 protein affects the reaction [Phenobarbital results in increased expression of SMPD2 mRNA] | CTD | PMID:19482888 | phenobarbital | increases expression | ISO | Smpd2 (Mus musculus) | 6480464 | Phenobarbital results in increased expression of SMPD2 mRNA | CTD | PMID:19482888 | pirinixic acid | increases expression | ISO | Smpd2 (Mus musculus) | 6480464 | pirinixic acid results in increased expression of SMPD2 mRNA | CTD | PMID:18301758 | sodium dichromate | decreases expression | ISO | Smpd2 (Mus musculus) | 6480464 | sodium bichromate results in decreased expression of SMPD2 mRNA | CTD | PMID:22155349 | sphingosine 1-phosphate | multiple interactions | ISO | SMPD2 (Homo sapiens) | 6480464 | sphingosine 1-phosphate inhibits the reaction [Thalidomide results in increased activity of SMPD2 protein] | CTD | PMID:15741222 | sunitinib | decreases expression | ISO | SMPD2 (Homo sapiens) | 6480464 | Sunitinib results in decreased expression of SMPD2 mRNA | CTD | PMID:31533062 | tetrachloromethane | increases activity | EXP | | 6480464 | Carbon Tetrachloride results in increased activity of SMPD2 protein | CTD | PMID:18226198 | tetrachloromethane | multiple interactions | EXP | | 6480464 | Flavonoids inhibits the reaction [Carbon Tetrachloride results in increased activity of SMPD2 protein] | CTD | PMID:18226198 | tetraphene | multiple interactions | ISO | Smpd2 (Mus musculus) | 6480464 | [Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of SMPD2 mRNA | CTD | PMID:27858113 | thalidomide | multiple interactions | ISO | SMPD2 (Homo sapiens) | 6480464 | sphingosine 1-phosphate inhibits the reaction [Thalidomide results in increased activity of SMPD2 protein] | CTD | PMID:15741222 | trichloroethene | increases methylation | EXP | | 6480464 | Trichloroethylene results in increased methylation of SMPD2 gene | CTD | PMID:27618143 | triptonide | decreases expression | ISO | Smpd2 (Mus musculus) | 6480464 | triptonide results in decreased expression of SMPD2 mRNA | CTD | PMID:33045310 | valproic acid | affects expression | ISO | Smpd2 (Mus musculus) | 6480464 | Valproic Acid affects the expression of SMPD2 mRNA | CTD | PMID:17963808 | valproic acid | increases methylation | ISO | SMPD2 (Homo sapiens) | 6480464 | Valproic Acid results in increased methylation of SMPD2 gene | CTD | PMID:29154799 | vancomycin | multiple interactions | EXP | | 6480464 | [Ampicillin co-treated with Neomycin co-treated with Gentamicins co-treated with Metronidazole co-treated with Vancomycin] results in increased expression of SMPD2 protein | CTD | PMID:30545405 | |