Atp1a4 (ATPase Na+/K+ transporting subunit alpha 4) - Rat Genome Database

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Gene: Atp1a4 (ATPase Na+/K+ transporting subunit alpha 4) Rattus norvegicus
Analyze
Symbol: Atp1a4
Name: ATPase Na+/K+ transporting subunit alpha 4
RGD ID: 61952
Description: Enables P-type sodium:potassium-exchanging transporter activity. Involved in flagellated sperm motility; regulation of cellular pH; and spermatogenesis. Predicted to be located in rod photoreceptor outer segment and sperm midpiece. Predicted to be part of sodium:potassium-exchanging ATPase complex. Predicted to be active in cell projection and plasma membrane. Orthologous to human ATP1A4 (ATPase Na+/K+ transporting subunit alpha 4); PARTICIPATES IN acebutolol pharmacodynamics pathway; adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway; alfentanil pharmacodynamics pathway; INTERACTS WITH 2,2',4,4'-Tetrabromodiphenyl ether; ammonium chloride; bisphenol A.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: ATPase, Na+/K+ transporting, alpha 4 polypeptide; LOC100365885; MGC93426; na(+)/K(+) ATPase alpha-4 subunit; sodium pump subunit alpha-4; sodium/potassium-transporting ATPase subunit alpha-4; sodium/potassium-transporting ATPase subunit alpha-4-like
RGD Orthologs
Human
Mouse
Bonobo
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81387,216,139 - 87,252,155 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1387,216,139 - 87,251,724 (-)EnsemblGRCr8
mRatBN7.21384,683,766 - 84,719,790 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1384,683,768 - 84,719,687 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1387,187,089 - 87,223,004 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01388,587,350 - 88,623,276 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01385,772,091 - 85,807,950 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01390,605,792 - 90,642,032 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1390,605,794 - 90,641,772 (-)Ensemblrn6Rnor6.0
Rnor_5.01395,126,899 - 95,163,433 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41388,213,848 - 88,249,075 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1384,295,133 - 84,329,808 (-)NCBICelera
RGSC_v3.11388,402,731 - 88,437,959 (-)NCBI
Cytogenetic Map13q24NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
acebutolol pharmacodynamics pathway   (ISO)
adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway   (ISO)
aldosterone signaling pathway  (IEA)
alfentanil pharmacodynamics pathway  (ISO)
amiloride pharmacodynamics pathway  (ISO)
amiodarone pharmacodynamics pathway  (ISO)
amlodipine pharmacodynamics pathway  (ISO)
atenolol pharmacodynamics pathway  (ISO)
bendroflumethiazide pharmacodynamics pathway  (ISO)
betaxolol pharmacodynamics pathway  (ISO)
bile acid transport pathway  (IEA)
bisoprolol pharmacodynamics pathway  (ISO)
bumetanide pharmacodynamics pathway  (ISO)
bupivacaine pharmacodynamics pathway  (ISO)
bupranolol drug pathway  (ISO)
bupranolol pharmacodynamics pathway  (ISO)
buprenorphine pharmacodynamics pathway  (ISO)
carvedilol pharmacodynamics pathway  (ISO)
chloroprocaine pharmacodynamics pathway  (ISO)
chlorothiazide pharmacodynamics pathway  (ISO)
chlorthalidone pharmacodynamics pathway  (ISO)
citalopram pharmacodynamics pathway  (ISO)
cocaine pharmacodynamics pathway  (ISO)
codeine and morphine pharmacodynamics pathway  (ISO)
cystinuria pathway  (ISO)
desipramine pharmacodynamics pathway  (ISO)
diltiazem pharmacodynamics pathway  (ISO)
diphenoxylate pharmacodynamics pathway  (ISO)
disopyramide pharmacodynamics pathway  (ISO)
dobutamine pharmacodynamics pathway  (ISO)
eplerenone pharmacodynamics pathway  (ISO)
escitalopram pharmacodynamics pathway  (ISO)
esmolol pharmacodynamics pathway  (ISO)
etacrynic acid pharmacodynamics pathway  (ISO)
ethylmorphine pharmacodynamics pathway  (ISO)
fentanyl pharmacodynamics pathway  (ISO)
flecainde pharmacodynamics pathway  (ISO)
fluoxetine pharmacodynamics pathway  (ISO)
fosphenytoin pharmacodynamics pathway  (ISO)
furosemide pharmacodynamics pathway  (ISO)
Hartnup disease pathway  (ISO)
heroin pharmacodynamics pathway  (ISO)
hydrochlorothiazide pharmacodynamics pathway  (ISO)
hydrocodone pharmacodynamics pathway  (ISO)
hydroflumethiazide pharmacodynamics pathway  (ISO)
hydromorphone pharmacodynamics pathway  (ISO)
ibutilide pharmacodynamics pathway  (ISO)
iminoglycinuria pathway  (ISO)
imipramine pharmacodynamics pathway  (ISO)
isoprenaline pharmacodynamics pathway  (ISO)
isradipine pharmacodynamics pathway  (ISO)
lactose degradation pathway  (ISO)
levacetylmethadol pharmacodynamics pathway  (ISO)
levobunolol pharmacodynamics pathway  (ISO)
levobupivacaine phgarmacodynamics pathway  (ISO)
levorphanol pharmacodynamics pathway  (ISO)
lidocaine pharmacodynamics pathway  (ISO)
lysinuric protein intolerance pathway  (ISO)
mepivacaine pharmacodynamics pathway  (ISO)
methadone pharmacodynamics pathway  (ISO)
metolazone pharmacodynamics pathway  (ISO)
metoprolol pharmacodynamics pathway  (ISO)
mexiletine pharmacodynamics pathway  (ISO)
nadolol pharmacodynamics pathway  (ISO)
nalbuphine pharmacodynamics pathway  (ISO)
naloxone pharmacodynamics pathway  (ISO)
naltrexone pharmacodynamics pathway  (ISO)
nebivolol pharmacodynamics pathway  (ISO)
nicotine pharmacodynamics pathway  (ISO)
nifedipine pharmacodynamics pathway  (ISO)
nimodipine pharmacodynamics pathway  (ISO)
nisoldipine pharmacodynamics pathway  (ISO)
nitrendipine pharmacodynamics pathway  (ISO)
oxybuprocaine pharmacodynamics pathway  (ISO)
oxycodone pharmacodynamics pathway  (ISO)
oxymorphone pharmacodynamics pathway  (ISO)
penbutolol pharmacodynamics pathway  (ISO)
pentazocine pharmacodynamics pathway  (ISO)
phenytoin pharmacodynamics pathway  (ISO)
pindolol pharmacodynamics pathway  (ISO)
prilocaine pharmacodynamics pathway  (ISO)
procainamide pharmacodynamics pathway  (ISO)
procaine pharmacodynamics pathway  (ISO)
propranolol pharmacodynamics pathway  (ISO)
quinidine pharmacodynamics pathway  (ISO)
remifentanil pharmacodynamics pathway  (ISO)
ropivacaine pharmacodynamics pathway  (ISO)
sotalol pharmacodynamics pathway  (ISO)
spironolactone pharmacodynamics pathway  (ISO)
timolol pharmacodynamics pathway  (ISO)
torasemide pharmacodynamics pathway  (ISO)
tramadol pharmacodynamics pathway  (ISO)
trehalose degradation pathway  (ISO)
triamterene pharmacodynamics pathway  (ISO)
trichlormethiazide pharmacodynamics pathway  (ISO)
verapamil pharmacodynamics pathway  (ISO)

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
4. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
5. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
6. GOA pipeline RGD automated data pipeline
7. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
8. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
9. A putative fourth Na+,K(+)-ATPase alpha-subunit gene is expressed in testis. Shamraj OI and Lingrel JB, Proc Natl Acad Sci U S A 1994 Dec 20;91(26):12952-6.
10. The Na,K-ATPase alpha4 gene (Atp1a4) encodes a ouabain-resistant alpha subunit and is tightly linked to the alpha2 gene (Atp1a2) on mouse chromosome 1. Underhill DA, etal., Biochemistry. 1999 Nov 9;38(45):14746-51.
11. Different expression and activity of the alpha1 and alpha4 isoforms of the Na,K-ATPase during rat male germ cell ontogeny. Wagoner K, etal., Reproduction. 2005 Nov;130(5):627-41.
12. Roles of the Na,K-ATPase alpha4 isoform and the Na+/H+ exchanger in sperm motility. Woo AL, etal., Mol Reprod Dev 2002 Jul;62(3):348-56.
Additional References at PubMed
PMID:12477932   PMID:12763881   PMID:16861705   PMID:20179187   PMID:20826726   PMID:21187400   PMID:22441762   PMID:23229519   PMID:26373354   PMID:26476261   PMID:27599714   PMID:30053369  


Genomics

Comparative Map Data
Atp1a4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81387,216,139 - 87,252,155 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1387,216,139 - 87,251,724 (-)EnsemblGRCr8
mRatBN7.21384,683,766 - 84,719,790 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1384,683,768 - 84,719,687 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1387,187,089 - 87,223,004 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01388,587,350 - 88,623,276 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01385,772,091 - 85,807,950 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01390,605,792 - 90,642,032 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1390,605,794 - 90,641,772 (-)Ensemblrn6Rnor6.0
Rnor_5.01395,126,899 - 95,163,433 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41388,213,848 - 88,249,075 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1384,295,133 - 84,329,808 (-)NCBICelera
RGSC_v3.11388,402,731 - 88,437,959 (-)NCBI
Cytogenetic Map13q24NCBI
ATP1A4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381160,151,603 - 160,186,980 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1160,151,586 - 160,186,980 (+)Ensemblhg38GRCh38
GRCh371160,121,393 - 160,156,770 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361158,387,976 - 158,423,391 (+)NCBIBuild 36Build 36hg18NCBI36
Build 341156,934,435 - 156,969,836NCBI
Celera1133,190,120 - 133,225,532 (+)NCBICelera
Cytogenetic Map1q23.2NCBI
HuRef1131,478,471 - 131,513,484 (+)NCBIHuRef
CHM1_11161,516,689 - 161,552,120 (+)NCBICHM1_1
T2T-CHM13v2.01159,288,690 - 159,324,059 (+)NCBIT2T-CHM13v2.0
Atp1a4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391172,051,075 - 172,085,991 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1172,051,080 - 172,085,981 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381172,223,508 - 172,258,424 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1172,223,513 - 172,258,414 (-)Ensemblmm10GRCm38
MGSCv371174,153,639 - 174,188,555 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
Celera1175,079,480 - 175,114,351 (-)NCBICelera
Cytogenetic Map1H3NCBI
cM Map179.54NCBI
ATP1A4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2189,663,062 - 89,701,813 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1189,403,023 - 89,441,794 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01135,504,929 - 135,540,651 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11139,426,556 - 139,462,393 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1139,426,556 - 139,462,393 (+)EnsemblpanPan2panpan1.1
LOC101966280
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244050586,275,960 - 6,308,838 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936740445,952 - 478,532 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_004936740445,952 - 478,580 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ATP1A4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1203,759,509 - 3,794,106 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl203,759,597 - 3,793,980 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_0236660382,816,977 - 2,852,218 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Atp1a4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247941,068,056 - 1,108,303 (-)NCBIHetGla 1.0HetGla 1.0hetGla2

Variants

.
Variants in Atp1a4
277 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:209
Count of miRNA genes:155
Interacting mature miRNAs:177
Transcripts:ENSRNOT00000064601
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1298066Bp159Blood pressure QTL 1590.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134863963493639634Rat
10755495Bp387Blood pressure QTL 3873.78arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)133721624190057603Rat
1354655Bp241Blood pressure QTL 2413.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1338975045103588154Rat
8655951Rf63Renal function QTL 6312.2blood urea nitrogen amount (VT:0005265)plasma urea nitrogen level (CMO:0000586)1371610804109350286Rat
4889606Gluco63Glucose level QTL 632.860.003blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1383286150109350286Rat
8655945Rf61Renal function QTL 613.6blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)137161080489333251Rat
71119Thym2Thymus enlargement QTL 23.8thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)134874981487285480Rat
1331783Bp221Blood pressure QTL 2213.72886arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)137161080489333251Rat
8655959Pur32Proteinuria QTL 328.4urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)137298450699745408Rat
1300166Kidm6Kidney mass QTL 63.93kidney mass (VT:0002707)single kidney wet weight to body weight ratio (CMO:0000622)137161080489333251Rat
2293687Bss26Bone structure and strength QTL 264.60.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)1367635937109350286Rat
619615Bp80Blood pressure QTL 800.0354arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)13742179187286911Rat
1581573Uae36Urinary albumin excretion QTL 36urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)13600200888706694Rat
724564Uae11Urinary albumin excretion QTL 115.7urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)134735425894285672Rat
738027Lnnr6Liver neoplastic nodule remodeling QTL 63.3liver integrity trait (VT:0010547)liver remodeling tumorous lesion number (CMO:0001461)1365613454109350286Rat
7207885Glom27Glomerulus QTL 273.9kidney glomerulus integrity trait (VT:0010546)kidney crescentic glomeruli count to kidney normal glomeruli count ratio (CMO:0002139)1321120177109350286Rat
7387280Uae43Urinary albumin excretion QTL 435.690.4174urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1368983334109350286Rat
738026Lnnr5Liver neoplastic nodule remodeling QTL 53.29liver integrity trait (VT:0010547)liver remodeling tumorous lesion number (CMO:0001461)136242459288113509Rat
2293702Bss34Bone structure and strength QTL 344.610.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)1367635937109350286Rat
1576318Schws5Schwannoma susceptibility QTL 50.0351nervous system integrity trait (VT:0010566)post-insult time to trigeminal nerve neurilemmoma formation (CMO:0002019)1364497900109350286Rat
1354621Rf47Renal function QTL 473.7kidney renin amount (VT:0010559)kidney renin level (CMO:0002166)1311081740103588154Rat
1581554Pur11Proteinuria QTL 11urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)13600200888706694Rat
12879475Bp400Blood pressure QTL 400arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1364375743109350286Rat
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)131103588154Rat
2293341Glom15Glomerulus QTL 159.1kidney glomerulus integrity trait (VT:0010546)kidney sclerotic glomeruli count to total glomeruli count ratio (CMO:0001269)1367635937109350286Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
12 12 26 118 72 71 40 62 40 6 243 121 10 91 62 56 31 10 10

Sequence


Ensembl Acc Id: ENSRNOT00000064601   ⟹   ENSRNOP00000062079
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1387,216,139 - 87,251,724 (-)Ensembl
mRatBN7.2 Ensembl1384,683,768 - 84,719,687 (-)Ensembl
Rnor_6.0 Ensembl1390,605,794 - 90,641,772 (-)Ensembl
RefSeq Acc Id: NM_001271030   ⟹   NP_001257959
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81387,216,139 - 87,252,054 (-)NCBI
mRatBN7.21384,683,768 - 84,719,687 (-)NCBI
Rnor_6.01390,605,794 - 90,641,772 (-)NCBI
Rnor_5.01395,126,899 - 95,163,433 (-)NCBI
Celera1384,295,133 - 84,329,808 (-)NCBI
Sequence:
RefSeq Acc Id: NM_022848   ⟹   NP_074039
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81387,216,139 - 87,252,054 (-)NCBI
mRatBN7.21384,683,768 - 84,719,687 (-)NCBI
Rnor_6.01390,605,794 - 90,641,772 (-)NCBI
Rnor_5.01395,126,899 - 95,163,433 (-)NCBI
RGSC_v3.41388,213,848 - 88,249,075 (-)RGD
Celera1384,295,133 - 84,329,808 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017598762   ⟹   XP_017454251
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81387,216,139 - 87,252,155 (-)NCBI
mRatBN7.21384,683,766 - 84,719,790 (-)NCBI
Rnor_6.01390,605,792 - 90,642,032 (-)NCBI
Sequence:
RefSeq Acc Id: XM_063272202   ⟹   XP_063128272
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81387,216,139 - 87,252,130 (-)NCBI
RefSeq Acc Id: NP_074039   ⟸   NM_022848
- UniProtKB: Q64541 (UniProtKB/Swiss-Prot),   Q5PQV3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001257959   ⟸   NM_001271030
- UniProtKB: Q64541 (UniProtKB/Swiss-Prot),   Q5PQV3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017454251   ⟸   XM_017598762
- Peptide Label: isoform X1
- Sequence:
Ensembl Acc Id: ENSRNOP00000062079   ⟸   ENSRNOT00000064601
RefSeq Acc Id: XP_063128272   ⟸   XM_063272202
- Peptide Label: isoform X1
Protein Domains
Cation-transporting P-type ATPase N-terminal

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q64541-F1-model_v2 AlphaFold Q64541 1-1028 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13699023
Promoter ID:EPDNEW_R9548
Type:initiation region
Name:Atp1a4_1
Description:ATPase Na+/K+ transporting subunit alpha 4
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01390,641,776 - 90,641,836EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:61952 AgrOrtholog
BioCyc Gene G2FUF-17327 BioCyc
Ensembl Genes ENSRNOG00000032378 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000064601 ENTREZGENE
Gene3D-CATH 3.40.1110.10 UniProtKB/Swiss-Prot
  3.40.50.1000 UniProtKB/Swiss-Prot
  Calcium-transporting ATPase, cytoplasmic transduction domain A UniProtKB/Swiss-Prot
  Calcium-transporting ATPase, transmembrane domain UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7113151 IMAGE-MGC_LOAD
InterPro ATPase_P-typ_cation-transptr_C UniProtKB/Swiss-Prot
  ATPase_P-typ_cation-transptr_N UniProtKB/Swiss-Prot
  ATPase_P-typ_cyto_dom_N UniProtKB/Swiss-Prot
  ATPase_P-typ_P_site UniProtKB/Swiss-Prot
  ATPase_P-typ_TM_dom_sf UniProtKB/Swiss-Prot
  ATPase_P-typ_transduc_dom_A_sf UniProtKB/Swiss-Prot
  Cation_transp_ATPase_P-type UniProtKB/Swiss-Prot
  HAD-like_sf UniProtKB/Swiss-Prot
  HAD_sf UniProtKB/Swiss-Prot
  P-type_ATPase_IIC UniProtKB/Swiss-Prot
  P_typ_ATPase UniProtKB/Swiss-Prot
  P_typ_ATPase_HD_dom UniProtKB/Swiss-Prot
KEGG Report rno:29132 UniProtKB/Swiss-Prot
MGC_CLONE MGC:93426 IMAGE-MGC_LOAD
NCBI Gene 29132 ENTREZGENE
PANTHER SODIUM/POTASSIUM-TRANSPORTING ATPASE SUBUNIT ALPHA UniProtKB/Swiss-Prot
  SODIUM/POTASSIUM-TRANSPORTING ATPASE SUBUNIT ALPHA-4 UniProtKB/Swiss-Prot
Pfam Cation_ATPase UniProtKB/Swiss-Prot
  Cation_ATPase_C UniProtKB/Swiss-Prot
  Cation_ATPase_N UniProtKB/Swiss-Prot
  E1-E2_ATPase UniProtKB/Swiss-Prot
  Hydrolase UniProtKB/Swiss-Prot
PhenoGen Atp1a4 PhenoGen
PRINTS CATATPASE UniProtKB/Swiss-Prot
  NAKATPASE UniProtKB/Swiss-Prot
PROSITE ATPASE_E1_E2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000032378 RatGTEx
SMART Cation_ATPase_N UniProtKB/Swiss-Prot
Superfamily-SCOP SSF56784 UniProtKB/Swiss-Prot
  SSF81653 UniProtKB/Swiss-Prot
  SSF81660 UniProtKB/Swiss-Prot
  SSF81665 UniProtKB/Swiss-Prot
UniProt AT1A4_RAT UniProtKB/Swiss-Prot
  Q5PQV3 ENTREZGENE, UniProtKB/TrEMBL
  Q64541 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-17 Atp1a4  ATPase Na+/K+ transporting subunit alpha 4  Atp1a4  ATPase, Na+/K+ transporting, alpha 4 polypeptide  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2013-04-12 Atp1a4  ATPase, Na+/K+ transporting, alpha 4 polypeptide  LOC100365885  sodium/potassium-transporting ATPase subunit alpha-4-like  Data merged from RGD:2318203 737654 PROVISIONAL
2010-05-05 LOC100365885  sodium/potassium-transporting ATPase subunit alpha-4-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2002-06-10 Atp1a4  ATPase, Na+/K+ transporting, alpha 4 polypeptide      Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference