Azin1 (antizyme inhibitor 1) - Rat Genome Database

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Gene: Azin1 (antizyme inhibitor 1) Rattus norvegicus
Analyze
Symbol: Azin1
Name: antizyme inhibitor 1
RGD ID: 61934
Description: Predicted to enable ornithine decarboxylase activator activity and ornithine decarboxylase activity. Involved in several processes, including estrous cycle; negative regulation of protein catabolic process; and positive regulation of centrosome duplication. Located in centrosome. Biomarker of pneumocystosis. Human ortholog(s) of this gene implicated in esophagus squamous cell carcinoma; hepatocellular carcinoma; and liver cirrhosis. Orthologous to human AZIN1 (antizyme inhibitor 1); PARTICIPATES IN polyamine metabolic pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene; 2,6-dinitrotoluene.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: AZI; Oazi; Oazin; ornithine decarboxylase antizyme inhibitor
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8771,539,711 - 71,566,515 (-)NCBIGRCr8
mRatBN7.2769,654,773 - 69,681,578 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl769,654,663 - 69,681,578 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx771,536,617 - 71,563,437 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0773,739,154 - 73,765,974 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0773,607,179 - 73,633,999 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0777,345,646 - 77,372,398 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl777,345,646 - 77,372,398 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0777,448,669 - 77,475,344 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4774,159,130 - 74,189,447 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1774,179,861 - 74,210,177 (-)NCBI
Celera766,713,070 - 66,739,866 (-)NCBICelera
Cytogenetic Map7q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model



  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Azin1RatDiabetic Nephropathies treatmentIEP 14700801 RGD 
Azin1Ratesophagus squamous cell carcinoma  ISOAZIN1 (Homo sapiens)14700707 RGD 
Azin1Rathepatocellular carcinoma disease_progressionISOAZIN1 (Homo sapiens)14700705RNA:increased editing:liverRGD 
Azin1Ratliver cirrhosis  ISOAZIN1 (Homo sapiens)14700702associated with hepatitis B and DNA SNP: :rs2679757 (human)RGD 
Azin1Ratliver cirrhosis  ISOAZIN1 (Homo sapiens)14700705associated with hepatocellular carcinoma and RNA:increased editing:liverRGD 
Azin1RatNeoplasm Metastasis  ISOAZIN1 (Homo sapiens)14700704associated with colorectal cancer and RNA:increased editing:colorectumRGD 
Azin1RatNeoplasm Metastasis  ISOAZIN1 (Homo sapiens)14700703associated with stomach cancer and RNA:increased editing:stomachRGD 
Azin1Ratpneumocystosis  IEP 14700806mRNA:increased expression:alveolar macrophageRGD 
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Azin1RatCohen syndrome  ISOAZIN1 (Homo sapiens)8554872ClinVar Annotator: match by term: Cohen syndromeClinVarPMID:28492532

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Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Azin1Rat(-)-epigallocatechin 3-gallate multiple interactionsISOAZIN1 (Homo sapiens)6480464[potassium chromate(VI) co-treated with epigallocatechin gallate] results in increased expression of AZIN1 mRNACTDPMID:22079256
Azin1Rat(1->4)-beta-D-glucan multiple interactionsISOAzin1 (Mus musculus)6480464[perfluorooctane sulfonic acid co-treated with Cellulose] results in decreased expression of AZIN1 mRNACTDPMID:36331819
Azin1Rat1,2-dichloroethane decreases expressionISOAzin1 (Mus musculus)6480464ethylene dichloride results in decreased expression of AZIN1 mRNACTDPMID:28960355
Azin1Rat1,2-dimethylhydrazine multiple interactionsISOAzin1 (Mus musculus)6480464[1 and 2-Dimethylhydrazine co-treated with Folic Acid] results in decreased expression of AZIN1 mRNACTDPMID:22206623
Azin1Rat1,2-dimethylhydrazine decreases expressionISOAzin1 (Mus musculus)64804641 and 2-Dimethylhydrazine results in decreased expression of AZIN1 mRNACTDPMID:22206623
Azin1Rat1-chloro-2,4-dinitrobenzene decreases expressionISOAZIN1 (Homo sapiens)6480464Dinitrochlorobenzene results in decreased expression of AZIN1 mRNACTDPMID:17374397
Azin1Rat17alpha-ethynylestradiol increases expressionISOAzin1 (Mus musculus)6480464Ethinyl Estradiol results in increased expression of AZIN1 mRNACTDPMID:17942748
Azin1Rat17beta-estradiol decreases expressionISOAzin1 (Mus musculus)6480464Estradiol results in decreased expression of AZIN1 mRNACTDPMID:39298647
Azin1Rat17beta-estradiol increases expressionISOAZIN1 (Homo sapiens)6480464Estradiol results in increased expression of AZIN1 mRNACTDPMID:31614463
Azin1Rat2,3,7,8-tetrachlorodibenzodioxine decreases expressionEXP 6480464Tetrachlorodibenzodioxin results in decreased expression of AZIN1 mRNACTDPMID:21215274 and PMID:34747641
Azin1Rat2,3,7,8-tetrachlorodibenzodioxine multiple interactionsISOAzin1 (Mus musculus)6480464[TIPARP gene mutant form results in increased susceptibility to Tetrachlorodibenzodioxin] which results in decreased expression of AZIN1 mRNACTDPMID:25975270
Azin1Rat2,3,7,8-tetrachlorodibenzodioxine affects expressionISOAzin1 (Mus musculus)6480464Tetrachlorodibenzodioxin affects the expression of AZIN1 mRNACTDPMID:21570461 and PMID:28922406
Azin1Rat2,4-dinitrotoluene affects expressionEXP 64804642 and 4-dinitrotoluene affects the expression of AZIN1 mRNACTDPMID:21346803
Azin1Rat2,6-dinitrotoluene affects expressionEXP 64804642 and 6-dinitrotoluene affects the expression of AZIN1 mRNACTDPMID:21346803
Azin1Rat2-amino-2-deoxy-D-glucopyranose decreases expressionEXP 6480464Glucosamine results in decreased expression of AZIN1 mRNACTDPMID:17109745
Azin1Rat2-amino-2-deoxy-D-glucopyranose multiple interactionsEXP 6480464IL1B promotes the reaction [Glucosamine results in increased expression of AZIN1 mRNA]CTDPMID:17109745
Azin1Rat2-butoxyethanol increases expressionISOAzin1 (Mus musculus)6480464n-butoxyethanol results in increased expression of AZIN1 mRNACTDPMID:19812364
Azin1Rat3,4-methylenedioxymethamphetamine increases expressionISOAzin1 (Mus musculus)6480464N-Methyl-3 and 4-methylenedioxyamphetamine results in increased expression of AZIN1 mRNACTDPMID:20188158
Azin1Rat3H-1,2-dithiole-3-thione decreases expressionEXP 64804641 and 2-dithiol-3-thione results in decreased expression of AZIN1 mRNACTDPMID:19162173
Azin1Rat4,4'-sulfonyldiphenol decreases expressionISOAzin1 (Mus musculus)6480464bisphenol S results in decreased expression of AZIN1 mRNACTDPMID:33297965 and PMID:39298647

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Biological Process
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Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Azin1Ratestrous cycle  IEP 14700804 RGD 
Azin1Ratnegative regulation of protein catabolic process  IDA 633334downregulates antizyme degradation of ODCRGD 
Azin1Ratnegative regulation of protein catabolic process involved_inIBAPANTHER:PTN002608075 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Azin1Ratnegative regulation of protein catabolic process involved_inISOAZIN1 (Homo sapiens)1624291 PMID:17900240RGDPMID:17900240
Azin1Ratnegative regulation of protein catabolic process involved_inIEAUniProtKB:O14977 and ensembl:ENSP000003371801600115GO_REF:0000107EnsemblGO_REF:0000107
Azin1Ratnegative regulation of protein catabolic process involved_inISSUniProtKB:O149771600115GO_REF:0000024UniProtGO_REF:0000024
Azin1Ratpolyamine biosynthetic process involved_inIEAInterPro:IPR0024331600115GO_REF:0000002InterProGO_REF:0000002
Azin1Ratpolyamine biosynthetic process involved_inIEAUniProtKB-KW:KW-06201600115GO_REF:0000043UniProtGO_REF:0000043
Azin1Ratpositive regulation of centrosome duplication  IMP 14700805 RGD 
Azin1Ratpositive regulation of epithelial cell proliferation  IDA 14700807 RGD 
Azin1Ratpositive regulation of polyamine transmembrane transport involved_inIEAUniProtKB:O35484 and ensembl:ENSMUSP000000655441600115GO_REF:0000107EnsemblGO_REF:0000107
Azin1Ratpositive regulation of polyamine transmembrane transport involved_inISOAzin1 (Mus musculus)1624291 PMID:18508777RGDPMID:18508777
Azin1Ratpositive regulation of polyamine transmembrane transport involved_inIBAMGI:1859169 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Azin1Ratpositive regulation of polyamine transmembrane transport involved_inISOAZIN1 (Homo sapiens)1624291 PMID:18508777RGDPMID:18508777
Azin1Ratpositive regulation of polyamine transmembrane transport involved_inIEAUniProtKB:O14977 and ensembl:ENSP000003371801600115GO_REF:0000107EnsemblGO_REF:0000107
Azin1Ratputrescine biosynthetic process from arginine, via ornithine involved_inIBAMGI:97402 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
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Cellular Component

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Azin1Ratcentrosome located_inIDA 14700805 RGD 
Azin1Ratcytoplasm is_active_inIBAMGI:2442093 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Azin1Ratnucleus located_inISOAzin1 (Mus musculus)1624291 PMID:19449338RGDPMID:19449338
Azin1Ratnucleus located_inIEAUniProtKB-SubCell:SL-01911600115GO_REF:0000044UniProtGO_REF:0000044
Azin1Ratnucleus located_inIEAUniProtKB-KW:KW-05391600115GO_REF:0000043UniProtGO_REF:0000043
Azin1Ratnucleus located_inIEAUniProtKB:O35484 and ensembl:ENSMUSP000000655441600115GO_REF:0000107EnsemblGO_REF:0000107
Azin1Ratnucleus located_inISSUniProtKB:O354841600115GO_REF:0000024UniProtGO_REF:0000024

Molecular Function
1 to 10 of 10 rows

  
1 to 10 of 10 rows

RGD Manual Annotations


  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Azin1Ratpolyamine metabolic pathway   ISOAZIN1 (Homo sapiens)7244195 RGD 

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#
Reference Title
Reference Citation
1. Recoding RNA editing of AZIN1 predisposes to hepatocellular carcinoma. Chen L, etal., Nat Med. 2013 Feb;19(2):209-16. doi: 10.1038/nm.3043. Epub 2013 Jan 6.
2. Expression of ODC1, SPD, SPM and AZIN1 in the hypothalamus, ovary and uterus during rat estrous cycle. Fernandes JRD, etal., Gen Comp Endocrinol. 2017 May 15;246:9-22. doi: 10.1016/j.ygcen.2017.03.005. Epub 2017 Mar 16.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
5. Regulation of cell proliferation by the antizyme inhibitor: evidence for an antizyme-independent mechanism. Kim SW, etal., J Cell Sci. 2006 Jun 15;119(Pt 12):2583-91. doi: 10.1242/jcs.02966. Epub 2006 May 30.
6. Cloning and sequencing of a human cDNA encoding ornithine decarboxylase antizyme inhibitor. Koguchi K, etal., Biochim Biophys Acta 1997 Sep 12;1353(3):209-16.
7. Pneumocystis mediates overexpression of antizyme inhibitor resulting in increased polyamine levels and apoptosis in alveolar macrophages. Liao CP, etal., J Biol Chem. 2009 Mar 20;284(12):8174-84. doi: 10.1074/jbc.M805787200. Epub 2009 Jan 20.
8. Antizyme, a mediator of ubiquitin-independent proteasomal degradation and its inhibitor localize to centrosomes and modulate centriole amplification. Mangold U, etal., Oncogene. 2008 Jan 24;27(5):604-13. doi: 10.1038/sj.onc.1210685. Epub 2007 Jul 30.
9. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
10. Cloning of antizyme inhibitor, a highly homologous protein to ornithine decarboxylase. Murakami Y, etal., J Biol Chem 1996 Feb 16;271(7):3340-2.
11. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
12. Enhanced AZIN1 RNA editing and overexpression of its regulatory enzyme ADAR1 are important prognostic biomarkers in gastric cancer. Okugawa Y, etal., J Transl Med. 2018 Dec 18;16(1):366. doi: 10.1186/s12967-018-1740-z.
13. Evidence of a role for antizyme and antizyme inhibitor as regulators of human cancer. Olsen RR and Zetter BR, Mol Cancer Res. 2011 Oct;9(10):1285-93. doi: 10.1158/1541-7786.MCR-11-0178. Epub 2011 Aug 17.
14. [Polymorphism of ornithine decarboxylase antizyme inhibitor 1 gene is associated with liver cirrhosis in Chinese hepatitis B patients]. Peng LJ, etal., Zhonghua Gan Zang Bing Za Zhi. 2011 Mar;19(3):169-73. doi: 10.3760/cma.j.issn.1007-3418.2011.03.005.
15. Adenosine-to-inosine RNA editing mediated by ADARs in esophageal squamous cell carcinoma. Qin YR, etal., Cancer Res. 2014 Feb 1;74(3):840-51. doi: 10.1158/0008-5472.CAN-13-2545. Epub 2013 Dec 3.
16. GOA pipeline RGD automated data pipeline
17. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
18. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
19. AZIN1 RNA editing confers cancer stemness and enhances oncogenic potential in colorectal cancer. Shigeyasu K, etal., JCI Insight. 2018 Jun 21;3(12). pii: 99976. doi: 10.1172/jci.insight.99976. eCollection 2018 Jun 21.
20. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
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PMID:2713421   PMID:16916800   PMID:17900240   PMID:18508777   PMID:19426728   PMID:19449338   PMID:19920120   PMID:25961839  



Azin1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8771,539,711 - 71,566,515 (-)NCBIGRCr8
mRatBN7.2769,654,773 - 69,681,578 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl769,654,663 - 69,681,578 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx771,536,617 - 71,563,437 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0773,739,154 - 73,765,974 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0773,607,179 - 73,633,999 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0777,345,646 - 77,372,398 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl777,345,646 - 77,372,398 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0777,448,669 - 77,475,344 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4774,159,130 - 74,189,447 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1774,179,861 - 74,210,177 (-)NCBI
Celera766,713,070 - 66,739,866 (-)NCBICelera
Cytogenetic Map7q22NCBI
AZIN1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh388102,826,302 - 102,864,200 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl8102,826,111 - 102,893,864 (-)EnsemblGRCh38hg38GRCh38
GRCh378103,838,530 - 103,876,428 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 368103,907,712 - 103,945,573 (-)NCBINCBI36Build 36hg18NCBI36
Build 348103,909,226 - 103,945,551NCBI
Celera8100,025,705 - 100,063,568 (-)NCBICelera
Cytogenetic Map8q22.3NCBI
HuRef899,039,532 - 99,077,262 (-)NCBIHuRef
CHM1_18103,878,803 - 103,916,656 (-)NCBICHM1_1
T2T-CHM13v2.08103,954,549 - 103,992,441 (-)NCBIT2T-CHM13v2.0
Azin1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391538,487,674 - 38,523,506 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1538,487,671 - 38,519,510 (-)EnsemblGRCm39 Ensembl
GRCm381538,487,430 - 38,519,294 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1538,487,427 - 38,519,266 (-)EnsemblGRCm38mm10GRCm38
MGSCv371538,417,185 - 38,449,021 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361538,432,019 - 38,463,855 (-)NCBIMGSCv36mm8
Celera1539,113,891 - 39,145,734 (-)NCBICelera
Cytogenetic Map15B3.1NCBI
cM Map1515.17NCBI
Azin1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541727,231,696 - 27,259,564 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495541727,231,695 - 27,259,564 (-)NCBIChiLan1.0ChiLan1.0
AZIN1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v27120,193,169 - 120,231,424 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1895,729,217 - 95,767,340 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0899,483,027 - 99,521,151 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.18101,639,950 - 101,678,604 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl8101,639,950 - 101,678,604 (-)Ensemblpanpan1.1panPan2
AZIN1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1134,363,996 - 4,396,069 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl134,361,340 - 4,396,040 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha134,364,236 - 4,396,246 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0134,523,489 - 4,555,507 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl134,523,405 - 4,555,498 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1134,365,307 - 4,397,317 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0134,482,535 - 4,514,517 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0134,495,739 - 4,527,724 (-)NCBIUU_Cfam_GSD_1.0
Azin1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440530333,375,842 - 33,406,444 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647040,801,943 - 40,834,003 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647040,801,943 - 40,832,543 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
AZIN1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl434,234,679 - 34,257,134 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1434,221,368 - 34,257,261 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2437,079,181 - 37,109,691 (+)NCBISscrofa10.2Sscrofa10.2susScr3
AZIN1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1897,679,775 - 97,717,486 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl897,679,468 - 97,696,928 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603942,881,918 - 42,921,274 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Azin1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476319,643,980 - 19,667,125 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462476319,643,980 - 19,667,125 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

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Variants in Azin1
93 total Variants

Predicted Target Of
Summary Value
Count of predictions:406
Count of miRNA genes:215
Interacting mature miRNAs:273
Transcripts:ENSRNOT00000007999
Prediction methods:Microtar, Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 35 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
1300179Kidm5Kidney mass QTL 53.51kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)743747012135012528Rat
2293667Bss42Bone structure and strength QTL 427.250.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra cross-sectional area (CMO:0001689)74765143992651439Rat
10053722Scort27Serum corticosterone level QTL 272.410.0083blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)74322875088228750Rat
1549840Bss5Bone structure and strength QTL 59.8femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)72475184169751841Rat
2317035Aia16Adjuvant induced arthritis QTL 162.71joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)759238038104238038Rat
1300127Srn1Serum renin concentration QTL 13.87blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)72940968384928080Rat
2293678Bss24Bone structure and strength QTL 246.710.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)74765143992651439Rat
1358361Sradr5Stress Responsive Adrenal Weight QTL 55.55adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)743747012108555253Rat
631513Scl7Serum cholesterol level QTL 74.1blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)73796056982960569Rat
2293685Bmd21Bone mineral density QTL 214.20.0003femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)74765143992651439Rat

1 to 10 of 35 rows
A001V45  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2769,656,097 - 69,656,204 (+)MAPPERmRatBN7.2
Rnor_6.0777,346,971 - 77,347,077NCBIRnor6.0
Rnor_5.0777,449,969 - 77,450,075UniSTSRnor5.0
RGSC_v3.4774,160,426 - 74,160,532UniSTSRGSC3.4
Celera766,714,395 - 66,714,501UniSTS
Cytogenetic Map7q22UniSTS
WI-9274  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21548,855,525 - 48,855,642 (+)MAPPERmRatBN7.2
mRatBN7.2769,655,461 - 69,655,578 (+)MAPPERmRatBN7.2
Rnor_6.0777,346,335 - 77,346,451NCBIRnor6.0
Rnor_6.01555,565,025 - 55,565,141NCBIRnor6.0
Rnor_5.0777,449,333 - 77,449,449UniSTSRnor5.0
Rnor_5.01559,286,894 - 59,287,010UniSTSRnor5.0
RGSC_v3.4774,159,790 - 74,159,906UniSTSRGSC3.4
RGSC_v3.41554,317,220 - 54,317,336UniSTSRGSC3.4
Celera766,713,759 - 66,713,875UniSTS
Cytogenetic Map7q22UniSTS
RH143277  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2769,680,631 - 69,680,771 (+)MAPPERmRatBN7.2
Rnor_6.0777,371,453 - 77,371,592NCBIRnor6.0
Rnor_5.0777,474,451 - 77,474,590UniSTSRnor5.0
RGSC_v3.4774,188,553 - 74,188,692UniSTSRGSC3.4
Celera766,738,920 - 66,739,059UniSTS
RH 3.4 Map7633.7UniSTS
Cytogenetic Map7q22UniSTS
RH140733  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21548,855,193 - 48,855,329 (+)MAPPERmRatBN7.2
mRatBN7.2769,655,122 - 69,655,265 (+)MAPPERmRatBN7.2
Rnor_6.0777,345,996 - 77,346,138NCBIRnor6.0
Rnor_6.01555,564,686 - 55,564,828NCBIRnor6.0
Rnor_5.0777,448,994 - 77,449,136UniSTSRnor5.0
Rnor_5.01559,286,555 - 59,286,697UniSTSRnor5.0
RGSC_v3.4774,159,451 - 74,159,593UniSTSRGSC3.4
Celera766,713,420 - 66,713,562UniSTS
RH 3.4 Map7633.3UniSTS
Cytogenetic Map7q22UniSTS
G19701  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2769,656,097 - 69,656,204 (+)MAPPERmRatBN7.2
Rnor_6.0777,346,971 - 77,347,077NCBIRnor6.0
Rnor_5.0777,449,969 - 77,450,075UniSTSRnor5.0
RGSC_v3.4774,160,426 - 74,160,532UniSTSRGSC3.4
Celera766,714,395 - 66,714,501UniSTS
Cytogenetic Map7q22UniSTS
Azin1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2769,658,063 - 69,659,554 (+)MAPPERmRatBN7.2
Rnor_6.0777,348,937 - 77,350,427NCBIRnor6.0
Rnor_5.0777,451,935 - 77,453,425UniSTSRnor5.0
Celera766,716,361 - 66,717,851UniSTS
Cytogenetic Map7q22UniSTS
Azin1rgdv877215464-A  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.0777,371,405 - 77,371,405 (+)RGDRnor6.0




alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31



Ensembl Acc Id: ENSRNOT00000007999   ⟹   ENSRNOP00000007999
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl769,654,773 - 69,681,578 (-)Ensembl
Rnor_6.0 Ensembl777,345,646 - 77,372,398 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000079644   ⟹   ENSRNOP00000069785
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl769,654,663 - 69,681,542 (-)Ensembl
Rnor_6.0 Ensembl777,345,646 - 77,372,398 (-)Ensembl
RefSeq Acc Id: NM_001301702   ⟹   NP_001288631
RefSeq Status: REVIEWED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8771,539,711 - 71,566,515 (-)NCBI
mRatBN7.2769,654,773 - 69,681,578 (-)NCBI
Rnor_6.0777,345,646 - 77,372,398 (-)NCBI
Celera766,713,070 - 66,739,866 (-)NCBI
Sequence:
RefSeq Acc Id: NM_022585   ⟹   NP_072107
RefSeq Status: REVIEWED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8771,539,711 - 71,566,515 (-)NCBI
mRatBN7.2769,654,773 - 69,681,578 (-)NCBI
Rnor_6.0777,345,646 - 77,372,398 (-)NCBI
Rnor_5.0777,448,669 - 77,475,344 (-)NCBI
RGSC_v3.4774,159,130 - 74,189,447 (-)RGD
Celera766,713,070 - 66,739,866 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006241568   ⟹   XP_006241630
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8771,539,736 - 71,566,265 (-)NCBI
mRatBN7.2769,654,798 - 69,681,573 (-)NCBI
Rnor_6.0777,345,671 - 77,372,393 (-)NCBI
Rnor_5.0777,448,669 - 77,475,344 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006241569   ⟹   XP_006241631
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8771,539,736 - 71,566,265 (-)NCBI
mRatBN7.2769,654,798 - 69,681,573 (-)NCBI
Rnor_6.0777,345,671 - 77,372,393 (-)NCBI
Rnor_5.0777,448,669 - 77,475,344 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017595068   ⟹   XP_017450557
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8771,539,736 - 71,551,907 (-)NCBI
mRatBN7.2769,654,798 - 69,666,970 (-)NCBI
Rnor_6.0777,345,671 - 77,358,161 (-)NCBI
Sequence:
RefSeq Acc Id: XM_063264178   ⟹   XP_063120248
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8771,539,736 - 71,566,265 (-)NCBI
RefSeq Acc Id: NP_072107   ⟸   NM_022585
- UniProtKB: Q63764 (UniProtKB/Swiss-Prot),   Q6P7R3 (UniProtKB/TrEMBL),   F7FJZ4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006241631   ⟸   XM_006241569
- Peptide Label: isoform X2
- UniProtKB: Q63764 (UniProtKB/Swiss-Prot),   A0A0G2JW87 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006241630   ⟸   XM_006241568
- Peptide Label: isoform X1
- UniProtKB: Q63764 (UniProtKB/Swiss-Prot),   Q6P7R3 (UniProtKB/TrEMBL),   F7FJZ4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001288631   ⟸   NM_001301702
- UniProtKB: Q63764 (UniProtKB/Swiss-Prot),   Q6P7R3 (UniProtKB/TrEMBL),   F7FJZ4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017450557   ⟸   XM_017595068
- Peptide Label: isoform X1
- UniProtKB: Q63764 (UniProtKB/Swiss-Prot),   Q6P7R3 (UniProtKB/TrEMBL),   F7FJZ4 (UniProtKB/TrEMBL)
- Sequence:
Orn/DAP/Arg decarboxylase 2 C-terminal   Orn/DAP/Arg decarboxylase 2 N-terminal

Name Modeler Protein Id AA Range Protein Structure
AF-Q63764-F1-model_v2 AlphaFold Q63764 1-448 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13695302
Promoter ID:EPDNEW_R5827
Type:single initiation site
Name:Azin1_1
Description:antizyme inhibitor 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0777,372,366 - 77,372,426EPDNEW


1 to 32 of 32 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-33587 BioCyc
Ensembl Genes ENSRNOG00000005333 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000007999 ENTREZGENE
Gene3D-CATH 3.20.20.10 UniProtKB/Swiss-Prot
  Lyase, Ornithine Decarboxylase, Chain A, domain 1 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:6918922 IMAGE-MGC_LOAD
InterPro Ala_racemase/Decarboxylase_C UniProtKB/Swiss-Prot
  Azin1 UniProtKB/Swiss-Prot
  De-COase2_C UniProtKB/Swiss-Prot
  De-COase2_CS UniProtKB/Swiss-Prot
  De-COase2_N UniProtKB/Swiss-Prot
  Orn/DAP/Arg_de-COase UniProtKB/Swiss-Prot
  Orn_de-COase UniProtKB/Swiss-Prot
  PLP-binding_barrel UniProtKB/Swiss-Prot
MGC_CLONE MGC:72823 IMAGE-MGC_LOAD
NCBI Gene 58961 ENTREZGENE
PANTHER PTHR11482 UniProtKB/Swiss-Prot
  PTHR11482:SF7 UniProtKB/Swiss-Prot
Pfam Orn_Arg_deC_N UniProtKB/Swiss-Prot
  Orn_DAP_Arg_deC UniProtKB/Swiss-Prot
PhenoGen Azin1 PhenoGen
PRINTS ODADCRBXLASE UniProtKB/Swiss-Prot
  ORNDCRBXLASE UniProtKB/Swiss-Prot
PROSITE ODR_DC_2_2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000005333 RatGTEx
Superfamily-SCOP SSF50621 UniProtKB/Swiss-Prot
  SSF51419 UniProtKB/Swiss-Prot
UniProt A0A0G2JW87 ENTREZGENE, UniProtKB/TrEMBL
  AZIN1_RAT UniProtKB/Swiss-Prot
  F7FJZ4 ENTREZGENE, UniProtKB/TrEMBL
  Q63764 ENTREZGENE
  Q6P7R3 ENTREZGENE, UniProtKB/TrEMBL
1 to 32 of 32 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2006-03-30 Azin1  antizyme inhibitor 1  Oazin  ornithine decarboxylase antizyme inhibitor  Symbol and Name updated 1299863 APPROVED
2004-09-10 Oazin  ornithine decarboxylase antizyme inhibitor  Oazi  ornithine decarboxylase antizyme inhibitor   Symbol updated 1299863 APPROVED
2002-06-10 Oazi  ornithine decarboxylase antizyme inhibitor       Name updated 70584 APPROVED

Note Type Note Reference
gene_physical_interaction binds to the antizyme releasing ornithine decarboxylase from ornithine decarboxylase-antizyme complex 633334