Azin1 (antizyme inhibitor 1) - Rat Genome Database

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Gene: Azin1 (antizyme inhibitor 1) Rattus norvegicus
Analyze
Symbol: Azin1
Name: antizyme inhibitor 1
RGD ID: 61934
Description: Predicted to enable ornithine decarboxylase activator activity and ornithine decarboxylase activity. Involved in several processes, including estrous cycle; negative regulation of protein catabolic process; and positive regulation of centrosome duplication. Located in centrosome. Biomarker of pneumocystosis. Human ortholog(s) of this gene implicated in esophagus squamous cell carcinoma; hepatocellular carcinoma; and liver cirrhosis. Orthologous to human AZIN1 (antizyme inhibitor 1); PARTICIPATES IN polyamine metabolic pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene; 2,6-dinitrotoluene.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: AZI; Oazi; Oazin; ornithine decarboxylase antizyme inhibitor
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8771,539,711 - 71,566,515 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl771,539,711 - 71,566,515 (-)EnsemblGRCr8
mRatBN7.2769,654,773 - 69,681,578 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl769,654,663 - 69,681,578 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx771,536,617 - 71,563,437 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0773,739,154 - 73,765,974 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0773,607,179 - 73,633,999 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0777,345,646 - 77,372,398 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl777,345,646 - 77,372,398 (-)Ensemblrn6Rnor6.0
Rnor_5.0777,448,669 - 77,475,344 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4774,159,130 - 74,189,447 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera766,713,070 - 66,739,866 (-)NCBICelera
RGSC_v3.1774,179,861 - 74,210,177 (-)NCBI
Cytogenetic Map7q22NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
(1->4)-beta-D-glucan  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (EXP)
2,6-dinitrotoluene  (EXP)
2-amino-2-deoxy-D-glucopyranose  (EXP)
2-butoxyethanol  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3H-1,2-dithiole-3-thione  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-(ethoxymethylene)-2-phenyloxazol-5-one  (ISO)
4-hydroxyphenyl retinamide  (ISO)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
acrolein  (ISO)
aflatoxin B1  (ISO)
aldehydo-D-glucosamine  (EXP)
all-trans-retinoic acid  (ISO)
alpha-pinene  (ISO)
amitrole  (EXP)
ammonium chloride  (EXP)
arsenite(3-)  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
beta-D-glucosamine  (EXP)
beta-lapachone  (ISO)
bisphenol A  (EXP,ISO)
buspirone  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
cadmium sulfate  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
choline  (ISO)
chromium(6+)  (ISO)
cisplatin  (ISO)
cobalt dichloride  (ISO)
copper(II) sulfate  (ISO)
coumarin  (ISO)
cyclosporin A  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (EXP,ISO)
diclofenac  (ISO)
dioxygen  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
epoxiconazole  (ISO)
ethanol  (ISO)
flutamide  (EXP)
folic acid  (ISO)
fulvestrant  (ISO)
gentamycin  (EXP)
graphite  (EXP)
GSK-J4  (ISO)
L-methionine  (ISO)
methapyrilene  (EXP)
methimazole  (EXP)
N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine  (ISO)
nefazodone  (EXP)
nickel subsulfide  (EXP)
nickel sulfate  (ISO)
ozone  (EXP,ISO)
paracetamol  (EXP,ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP)
phenobarbital  (EXP,ISO)
pirinixic acid  (ISO)
potassium chromate  (ISO)
potassium dichromate  (ISO)
resveratrol  (ISO)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sulfadimethoxine  (EXP)
sulfasalazine  (ISO)
sunitinib  (ISO)
tamibarotene  (ISO)
tamoxifen  (ISO)
tert-butyl hydroperoxide  (ISO)
tetraphene  (ISO)
titanium dioxide  (ISO)
valproic acid  (EXP,ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
centrosome  (IDA)
cytoplasm  (IBA)
nucleus  (IEA,ISO,ISS)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Recoding RNA editing of AZIN1 predisposes to hepatocellular carcinoma. Chen L, etal., Nat Med. 2013 Feb;19(2):209-16. doi: 10.1038/nm.3043. Epub 2013 Jan 6.
2. Expression of ODC1, SPD, SPM and AZIN1 in the hypothalamus, ovary and uterus during rat estrous cycle. Fernandes JRD, etal., Gen Comp Endocrinol. 2017 May 15;246:9-22. doi: 10.1016/j.ygcen.2017.03.005. Epub 2017 Mar 16.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
5. Regulation of cell proliferation by the antizyme inhibitor: evidence for an antizyme-independent mechanism. Kim SW, etal., J Cell Sci. 2006 Jun 15;119(Pt 12):2583-91. doi: 10.1242/jcs.02966. Epub 2006 May 30.
6. Cloning and sequencing of a human cDNA encoding ornithine decarboxylase antizyme inhibitor. Koguchi K, etal., Biochim Biophys Acta 1997 Sep 12;1353(3):209-16.
7. Pneumocystis mediates overexpression of antizyme inhibitor resulting in increased polyamine levels and apoptosis in alveolar macrophages. Liao CP, etal., J Biol Chem. 2009 Mar 20;284(12):8174-84. doi: 10.1074/jbc.M805787200. Epub 2009 Jan 20.
8. Antizyme, a mediator of ubiquitin-independent proteasomal degradation and its inhibitor localize to centrosomes and modulate centriole amplification. Mangold U, etal., Oncogene. 2008 Jan 24;27(5):604-13. doi: 10.1038/sj.onc.1210685. Epub 2007 Jul 30.
9. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
10. Cloning of antizyme inhibitor, a highly homologous protein to ornithine decarboxylase. Murakami Y, etal., J Biol Chem 1996 Feb 16;271(7):3340-2.
11. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
12. Enhanced AZIN1 RNA editing and overexpression of its regulatory enzyme ADAR1 are important prognostic biomarkers in gastric cancer. Okugawa Y, etal., J Transl Med. 2018 Dec 18;16(1):366. doi: 10.1186/s12967-018-1740-z.
13. Evidence of a role for antizyme and antizyme inhibitor as regulators of human cancer. Olsen RR and Zetter BR, Mol Cancer Res. 2011 Oct;9(10):1285-93. doi: 10.1158/1541-7786.MCR-11-0178. Epub 2011 Aug 17.
14. [Polymorphism of ornithine decarboxylase antizyme inhibitor 1 gene is associated with liver cirrhosis in Chinese hepatitis B patients]. Peng LJ, etal., Zhonghua Gan Zang Bing Za Zhi. 2011 Mar;19(3):169-73. doi: 10.3760/cma.j.issn.1007-3418.2011.03.005.
15. Adenosine-to-inosine RNA editing mediated by ADARs in esophageal squamous cell carcinoma. Qin YR, etal., Cancer Res. 2014 Feb 1;74(3):840-51. doi: 10.1158/0008-5472.CAN-13-2545. Epub 2013 Dec 3.
16. GOA pipeline RGD automated data pipeline
17. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
18. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
19. AZIN1 RNA editing confers cancer stemness and enhances oncogenic potential in colorectal cancer. Shigeyasu K, etal., JCI Insight. 2018 Jun 21;3(12). pii: 99976. doi: 10.1172/jci.insight.99976. eCollection 2018 Jun 21.
20. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
21. Pancreatic Kininogenase Ameliorates Renal Fibrosis in Streptozotocin Induced-Diabetic Nephropathy Rat. Zhu D, etal., Kidney Blood Press Res. 2016;41(1):9-17. doi: 10.1159/000368542. Epub 2016 Jan 8.
Additional References at PubMed
PMID:2713421   PMID:16916800   PMID:17900240   PMID:18508777   PMID:19426728   PMID:19449338   PMID:19920120   PMID:25961839  


Genomics

Comparative Map Data
Azin1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8771,539,711 - 71,566,515 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl771,539,711 - 71,566,515 (-)EnsemblGRCr8
mRatBN7.2769,654,773 - 69,681,578 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl769,654,663 - 69,681,578 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx771,536,617 - 71,563,437 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0773,739,154 - 73,765,974 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0773,607,179 - 73,633,999 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0777,345,646 - 77,372,398 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl777,345,646 - 77,372,398 (-)Ensemblrn6Rnor6.0
Rnor_5.0777,448,669 - 77,475,344 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4774,159,130 - 74,189,447 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera766,713,070 - 66,739,866 (-)NCBICelera
RGSC_v3.1774,179,861 - 74,210,177 (-)NCBI
Cytogenetic Map7q22NCBI
AZIN1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh388102,826,302 - 102,864,200 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl8102,826,111 - 102,893,864 (-)Ensemblhg38GRCh38
GRCh378103,838,530 - 103,876,428 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 368103,907,712 - 103,945,573 (-)NCBIBuild 36Build 36hg18NCBI36
Build 348103,909,226 - 103,945,551NCBI
Celera8100,025,705 - 100,063,568 (-)NCBICelera
Cytogenetic Map8q22.3NCBI
HuRef899,039,532 - 99,077,262 (-)NCBIHuRef
CHM1_18103,878,803 - 103,916,656 (-)NCBICHM1_1
T2T-CHM13v2.08103,954,549 - 103,992,441 (-)NCBIT2T-CHM13v2.0
Azin1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391538,487,674 - 38,523,506 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1538,487,671 - 38,519,510 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381538,487,430 - 38,519,294 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1538,487,427 - 38,519,266 (-)Ensemblmm10GRCm38
MGSCv371538,417,185 - 38,449,021 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361538,432,019 - 38,463,855 (-)NCBIMGSCv36mm8
Celera1539,113,891 - 39,145,734 (-)NCBICelera
Cytogenetic Map15B3.1NCBI
cM Map1515.17NCBI
Azin1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541727,231,696 - 27,259,564 (-)Ensembl
ChiLan1.0NW_00495541727,231,695 - 27,259,564 (-)NCBIChiLan1.0ChiLan1.0
AZIN1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v27120,193,169 - 120,231,424 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1895,729,217 - 95,767,340 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0899,483,027 - 99,521,151 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.18101,639,950 - 101,678,604 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl8101,639,950 - 101,678,604 (-)EnsemblpanPan2panpan1.1
AZIN1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1134,363,996 - 4,396,069 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl134,361,340 - 4,396,040 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha134,364,236 - 4,396,246 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0134,523,489 - 4,555,507 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl134,523,405 - 4,555,498 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1134,365,307 - 4,397,317 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0134,482,535 - 4,514,517 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0134,495,739 - 4,527,724 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Azin1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440530333,375,842 - 33,406,444 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647040,801,943 - 40,834,003 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493647040,801,943 - 40,832,543 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
AZIN1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl434,234,679 - 34,257,134 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1434,221,368 - 34,257,261 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2437,079,181 - 37,109,691 (+)NCBISscrofa10.2Sscrofa10.2susScr3
AZIN1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1897,679,775 - 97,717,486 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl897,679,468 - 97,696,928 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366603942,881,918 - 42,921,274 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Azin1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476319,643,980 - 19,667,125 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462476319,643,980 - 19,667,125 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Azin1
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11212,533,983 - 212,560,793 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Azin1
271 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:406
Count of miRNA genes:215
Interacting mature miRNAs:273
Transcripts:ENSRNOT00000007999
Prediction methods:Microtar, Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
10053722Scort27Serum corticosterone level QTL 272.410.0083blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)74511390390113903Rat
1549840Bss5Bone structure and strength QTL 59.8femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)72663805771638057Rat
2317035Aia16Adjuvant induced arthritis QTL 162.71joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)771103011106126789Rat
1357336Gluco6Glucose level QTL 63.4blood glucose amount (VT:0000188)serum glucose level (CMO:0000543)75170064396700643Rat
1300127Srn1Serum renin concentration QTL 13.87blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)72417947886817926Rat
1358361Sradr5Stress Responsive Adrenal Weight QTL 55.55adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)731770293110435881Rat
1298525Cm1Cardiac mass QTL 12.7heart mass (VT:0007028)heart wet weight (CMO:0000069)756625161101625161Rat
631513Scl7Serum cholesterol level QTL 74.1blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)73984590284845902Rat
631504Cm27Cardiac mass QTL 273.45heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)746307490127866166Rat
10755453Coatc12Coat color QTL 120coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)73299870277998702Rat
1559283Emca4Estrogen-induced mammary cancer QTL 43.7mammary gland integrity trait (VT:0010552)percentage of study population developing mammary tumors during a period of time (CMO:0000948)763889858108889858Rat
1300151Bp181Blood pressure QTL 1813.36arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)755498584105834451Rat
7411605Foco14Food consumption QTL 1424.10.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)73617876481178764Rat
738030Anxrr8Anxiety related response QTL 84.1exploratory behavior trait (VT:0010471)number of entries into a discrete space in an experimental apparatus (CMO:0000960)74847504993475049Rat
1643004Pain2Pain QTL 21mechanical nociception trait (VT:0002734)self mutilation severity score (CMO:0002145)71011291699900612Rat
1300149Cm6Cardiac mass QTL 64.09heart mass (VT:0007028)heart left ventricle weight to body weight ratio (CMO:0000530)71104117804Rat
631534Lnnr1Liver neoplastic nodule remodeling QTL 13.850.001liver integrity trait (VT:0010547)liver remodeling tumorous lesion number to liver total tumorous lesion number ratio (CMO:0001705)73617876481178764Rat
634336Anxrr17Anxiety related response QTL 173.66locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)71509236116977875Rat
61357Bp38Blood pressure QTL 381.60.052arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)740540077123682549Rat
2316947Rf58Renal function QTL 587.8kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)749682832115766396Rat
1298528Bp169Blood pressure QTL 1690.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)762963207107963207Rat
1576303Ept7Estrogen-induced pituitary tumorigenesis QTL 73.7pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)763889858108889858Rat
1300132Bp182Blood pressure QTL 1823.49arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)72154197786817926Rat
2316955Stl24Serum triglyceride level QTL 247.1blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)749682832115766396Rat
2316952Pur22Proteinuria QTL 225.2urine protein amount (VT:0005160)urine protein level (CMO:0000591)749682832115766396Rat
2303582Gluco53Glucose level QTL 533blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)74860308793603087Rat
61439Cia8Collagen induced arthritis QTL 85.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)72718291472182914Rat

Markers in Region
A001V45  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2769,656,097 - 69,656,204 (+)MAPPERmRatBN7.2
Rnor_6.0777,346,971 - 77,347,077NCBIRnor6.0
Rnor_5.0777,449,969 - 77,450,075UniSTSRnor5.0
RGSC_v3.4774,160,426 - 74,160,532UniSTSRGSC3.4
Celera766,714,395 - 66,714,501UniSTS
Cytogenetic Map7q22UniSTS
WI-9274  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21548,855,525 - 48,855,642 (+)MAPPERmRatBN7.2
mRatBN7.2769,655,461 - 69,655,578 (+)MAPPERmRatBN7.2
Rnor_6.0777,346,335 - 77,346,451NCBIRnor6.0
Rnor_6.01555,565,025 - 55,565,141NCBIRnor6.0
Rnor_5.0777,449,333 - 77,449,449UniSTSRnor5.0
Rnor_5.01559,286,894 - 59,287,010UniSTSRnor5.0
RGSC_v3.4774,159,790 - 74,159,906UniSTSRGSC3.4
RGSC_v3.41554,317,220 - 54,317,336UniSTSRGSC3.4
Celera766,713,759 - 66,713,875UniSTS
Cytogenetic Map7q22UniSTS
RH143277  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2769,680,631 - 69,680,771 (+)MAPPERmRatBN7.2
Rnor_6.0777,371,453 - 77,371,592NCBIRnor6.0
Rnor_5.0777,474,451 - 77,474,590UniSTSRnor5.0
RGSC_v3.4774,188,553 - 74,188,692UniSTSRGSC3.4
Celera766,738,920 - 66,739,059UniSTS
RH 3.4 Map7633.7UniSTS
Cytogenetic Map7q22UniSTS
RH140733  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21548,855,193 - 48,855,329 (+)MAPPERmRatBN7.2
mRatBN7.2769,655,122 - 69,655,265 (+)MAPPERmRatBN7.2
Rnor_6.0777,345,996 - 77,346,138NCBIRnor6.0
Rnor_6.01555,564,686 - 55,564,828NCBIRnor6.0
Rnor_5.0777,448,994 - 77,449,136UniSTSRnor5.0
Rnor_5.01559,286,555 - 59,286,697UniSTSRnor5.0
RGSC_v3.4774,159,451 - 74,159,593UniSTSRGSC3.4
Celera766,713,420 - 66,713,562UniSTS
RH 3.4 Map7633.3UniSTS
Cytogenetic Map7q22UniSTS
G19701  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2769,656,097 - 69,656,204 (+)MAPPERmRatBN7.2
Rnor_6.0777,346,971 - 77,347,077NCBIRnor6.0
Rnor_5.0777,449,969 - 77,450,075UniSTSRnor5.0
RGSC_v3.4774,160,426 - 74,160,532UniSTSRGSC3.4
Celera766,714,395 - 66,714,501UniSTS
Cytogenetic Map7q22UniSTS
Azin1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2769,658,063 - 69,659,554 (+)MAPPERmRatBN7.2
Rnor_6.0777,348,937 - 77,350,427NCBIRnor6.0
Rnor_5.0777,451,935 - 77,453,425UniSTSRnor5.0
Celera766,716,361 - 66,717,851UniSTS
Cytogenetic Map7q22UniSTS
Azin1rgdv877215464-A  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.0777,371,405 - 77,371,405 (+)RGDRnor6.0


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000007999   ⟹   ENSRNOP00000007999
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl771,539,711 - 71,566,515 (-)Ensembl
mRatBN7.2 Ensembl769,654,773 - 69,681,578 (-)Ensembl
Rnor_6.0 Ensembl777,345,646 - 77,372,398 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000079644   ⟹   ENSRNOP00000069785
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl769,654,663 - 69,681,542 (-)Ensembl
Rnor_6.0 Ensembl777,345,646 - 77,372,398 (-)Ensembl
RefSeq Acc Id: NM_001301702   ⟹   NP_001288631
RefSeq Status: REVIEWED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8771,539,711 - 71,566,515 (-)NCBI
mRatBN7.2769,654,773 - 69,681,578 (-)NCBI
Rnor_6.0777,345,646 - 77,372,398 (-)NCBI
Celera766,713,070 - 66,739,866 (-)NCBI
Sequence:
RefSeq Acc Id: NM_022585   ⟹   NP_072107
RefSeq Status: REVIEWED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8771,539,711 - 71,566,515 (-)NCBI
mRatBN7.2769,654,773 - 69,681,578 (-)NCBI
Rnor_6.0777,345,646 - 77,372,398 (-)NCBI
Rnor_5.0777,448,669 - 77,475,344 (-)NCBI
RGSC_v3.4774,159,130 - 74,189,447 (-)RGD
Celera766,713,070 - 66,739,866 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006241568   ⟹   XP_006241630
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8771,539,736 - 71,566,265 (-)NCBI
mRatBN7.2769,654,798 - 69,681,573 (-)NCBI
Rnor_6.0777,345,671 - 77,372,393 (-)NCBI
Rnor_5.0777,448,669 - 77,475,344 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006241569   ⟹   XP_006241631
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8771,539,736 - 71,566,265 (-)NCBI
mRatBN7.2769,654,798 - 69,681,573 (-)NCBI
Rnor_6.0777,345,671 - 77,372,393 (-)NCBI
Rnor_5.0777,448,669 - 77,475,344 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017595068   ⟹   XP_017450557
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8771,539,736 - 71,551,907 (-)NCBI
mRatBN7.2769,654,798 - 69,666,970 (-)NCBI
Rnor_6.0777,345,671 - 77,358,161 (-)NCBI
Sequence:
RefSeq Acc Id: XM_063264178   ⟹   XP_063120248
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8771,539,736 - 71,566,265 (-)NCBI
RefSeq Acc Id: NP_072107   ⟸   NM_022585
- UniProtKB: Q63764 (UniProtKB/Swiss-Prot),   Q6P7R3 (UniProtKB/TrEMBL),   F7FJZ4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006241631   ⟸   XM_006241569
- Peptide Label: isoform X2
- UniProtKB: Q63764 (UniProtKB/Swiss-Prot),   A0A0G2JW87 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006241630   ⟸   XM_006241568
- Peptide Label: isoform X1
- UniProtKB: Q63764 (UniProtKB/Swiss-Prot),   Q6P7R3 (UniProtKB/TrEMBL),   F7FJZ4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001288631   ⟸   NM_001301702
- UniProtKB: Q63764 (UniProtKB/Swiss-Prot),   Q6P7R3 (UniProtKB/TrEMBL),   F7FJZ4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017450557   ⟸   XM_017595068
- Peptide Label: isoform X1
- UniProtKB: Q63764 (UniProtKB/Swiss-Prot),   Q6P7R3 (UniProtKB/TrEMBL),   F7FJZ4 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000069785   ⟸   ENSRNOT00000079644
Ensembl Acc Id: ENSRNOP00000007999   ⟸   ENSRNOT00000007999
RefSeq Acc Id: XP_063120248   ⟸   XM_063264178
- Peptide Label: isoform X2
- UniProtKB: Q63764 (UniProtKB/Swiss-Prot),   A0A0G2JW87 (UniProtKB/TrEMBL)
Protein Domains
Orn/DAP/Arg decarboxylase 2 C-terminal   Orn/DAP/Arg decarboxylase 2 N-terminal

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q63764-F1-model_v2 AlphaFold Q63764 1-448 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13695302
Promoter ID:EPDNEW_R5827
Type:single initiation site
Name:Azin1_1
Description:antizyme inhibitor 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0777,372,366 - 77,372,426EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:61934 AgrOrtholog
BioCyc Gene G2FUF-33587 BioCyc
Ensembl Genes ENSRNOG00000005333 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000007999 ENTREZGENE
Gene3D-CATH 3.20.20.10 UniProtKB/Swiss-Prot
  Lyase, Ornithine Decarboxylase, Chain A, domain 1 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:6918922 IMAGE-MGC_LOAD
InterPro Ala_racemase/Decarboxylase_C UniProtKB/Swiss-Prot
  Azin1 UniProtKB/Swiss-Prot
  De-COase2_C UniProtKB/Swiss-Prot
  De-COase2_CS UniProtKB/Swiss-Prot
  De-COase2_N UniProtKB/Swiss-Prot
  Orn/DAP/Arg_de-COase UniProtKB/Swiss-Prot
  Orn_de-COase UniProtKB/Swiss-Prot
  PLP-binding_barrel UniProtKB/Swiss-Prot
MGC_CLONE MGC:72823 IMAGE-MGC_LOAD
NCBI Gene 58961 ENTREZGENE
PANTHER PTHR11482 UniProtKB/Swiss-Prot
  PTHR11482:SF7 UniProtKB/Swiss-Prot
Pfam Orn_Arg_deC_N UniProtKB/Swiss-Prot
  Orn_DAP_Arg_deC UniProtKB/Swiss-Prot
PhenoGen Azin1 PhenoGen
PRINTS ODADCRBXLASE UniProtKB/Swiss-Prot
  ORNDCRBXLASE UniProtKB/Swiss-Prot
PROSITE ODR_DC_2_2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000005333 RatGTEx
Superfamily-SCOP SSF50621 UniProtKB/Swiss-Prot
  SSF51419 UniProtKB/Swiss-Prot
UniProt A0A0G2JW87 ENTREZGENE
  AZIN1_RAT UniProtKB/Swiss-Prot
  F7FJZ4 ENTREZGENE, UniProtKB/TrEMBL
  Q63764 ENTREZGENE
  Q6P7R3 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2006-03-30 Azin1  antizyme inhibitor 1  Oazin  ornithine decarboxylase antizyme inhibitor  Symbol and Name updated 1299863 APPROVED
2004-09-10 Oazin  ornithine decarboxylase antizyme inhibitor  Oazi  ornithine decarboxylase antizyme inhibitor   Symbol updated 1299863 APPROVED
2002-06-10 Oazi  ornithine decarboxylase antizyme inhibitor       Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_physical_interaction binds to the antizyme releasing ornithine decarboxylase from ornithine decarboxylase-antizyme complex 633334