Atp5mc1 (ATP synthase membrane subunit c locus 1) - Rat Genome Database

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Gene: Atp5mc1 (ATP synthase membrane subunit c locus 1) Rattus norvegicus
Analyze
Symbol: Atp5mc1
Name: ATP synthase membrane subunit c locus 1
RGD ID: 61933
Description: Enables ligand-gated channel activity. Involved in several processes, including cellular response to L-glutamate; cold acclimation; and negative regulation of mitochondrial membrane potential. Located in distal axon and neuronal cell body. Part of proton-transporting ATP synthase complex. Orthologous to human ATP5MC1 (ATP synthase membrane subunit c locus 1); PARTICIPATES IN Alzheimer's disease pathway; Huntington's disease pathway; oxidative phosphorylation pathway; INTERACTS WITH 17alpha-ethynylestradiol; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: ATP synthase F(0) complex subunit C1, mitochondrial; ATP synthase H+ transporting mitochondrial F0 complex subunit c (subunit 9); ATP synthase H+ transporting mitochondrial F0 complex subunit c (subunit 9) isoform 1; ATP synthase lipid-binding protein; ATP synthase lipid-binding protein, mitochondrial; ATP synthase proteolipid P1; ATP synthase, H+ transporting, mitochondrial F0 complex, subunit c (subunit 9); ATP synthase, H+ transporting, mitochondrial F0 complex, subunit c (subunit 9), isoform 1; ATP synthase, H+ transporting, mitochondrial F0 complex, subunit c, isoform 1; ATP synthase, H+ transporting, mitochondrial F0 complex, subunit C1 (subunit 9); ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C1 (subunit 9); Atp5g1; ATPase protein 9; ATPase subunit c; proton-conducting channel, ATP synthase F(0) complex subunit c
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81081,520,762 - 81,523,735 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1081,520,765 - 81,523,363 (-)EnsemblGRCr8
mRatBN7.21081,024,056 - 81,026,780 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1081,024,064 - 81,026,284 (+)EnsemblmRatBN7.2
mRatBN7.2 Ensembl1081,023,925 - 81,027,124 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1085,972,277 - 85,974,869 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01085,470,315 - 85,472,907 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01080,863,050 - 80,865,635 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01083,895,941 - 83,898,640 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1083,895,947 - 83,898,527 (-)Ensemblrn6Rnor6.0
Rnor_5.01083,700,811 - 83,703,481 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41084,788,650 - 84,791,230 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1079,791,879 - 79,794,459 (-)NCBICelera
RGSC_v3.11084,803,019 - 84,805,600 (-)NCBI
Cytogenetic Map10q26NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
1,2,4-trichloro-5-(2,5-dichlorophenyl)benzene  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,4'-trichlorobiphenyl  (ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2-nitrofluorene  (EXP)
3,4-methylenedioxymethamphetamine  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one  (EXP)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
alpha-Zearalanol  (EXP)
amitrole  (EXP)
ammonium chloride  (EXP)
Aroclor 1254  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
atrazine  (ISO)
azoxystrobin  (EXP)
benzo[a]pyrene  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
Butylbenzyl phthalate  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
carbon nanotube  (ISO)
celastrol  (ISO)
CGP 52608  (ISO)
chlorpyrifos  (EXP,ISO)
cisplatin  (ISO)
cobalt dichloride  (ISO)
copper atom  (EXP)
copper(0)  (EXP)
copper(II) sulfate  (ISO)
coumestrol  (ISO)
cyclosporin A  (ISO)
DDE  (ISO)
diarsenic trioxide  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (EXP,ISO)
diquat  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
Enterolactone  (ISO)
ethanol  (EXP)
ethyl methanesulfonate  (ISO)
fipronil  (EXP)
flutamide  (EXP)
formaldehyde  (ISO)
genistein  (EXP)
gentamycin  (EXP)
glafenine  (EXP)
glyphosate  (EXP)
imidacloprid  (EXP)
isoniazide  (ISO)
isoprenaline  (EXP)
leflunomide  (ISO)
lipopolysaccharide  (ISO)
maneb  (ISO)
methimazole  (EXP)
methoxychlor  (EXP)
methyl methanesulfonate  (ISO)
methylparaben  (ISO)
N-nitrosodimethylamine  (EXP)
nefazodone  (EXP)
nimesulide  (EXP)
nitrofen  (EXP)
paracetamol  (ISO)
paraquat  (ISO)
PCB138  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP)
phenobarbital  (ISO)
PhIP  (EXP)
piroxicam  (ISO)
potassium dichromate  (ISO)
quercetin  (ISO)
resveratrol  (ISO)
SB 431542  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenite  (ISO)
sulfadimethoxine  (EXP)
sulforaphane  (ISO)
sunitinib  (ISO)
tamoxifen  (EXP,ISO)
tetrachloroethene  (ISO)
thapsigargin  (ISO)
thiabendazole  (EXP)
thiram  (ISO)
titanium dioxide  (ISO)
trichloroethene  (ISO)
tungsten  (ISO)
tunicamycin  (ISO)
urethane  (ISO)
valproic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. ATP synthase subunit c expression: physiological regulation of the P1 and P2 genes. Andersson U, etal., Biochem J. 1997 Apr 15;323 ( Pt 2):379-85.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Molecular cloning and sequence of cDNAs for the import precursors of oligomycin sensitivity conferring protein, ATPase inhibitor protein, and subunit c of H(+)-ATP synthase in rat mitochondria. Higuti T, etal., Biochim Biophys Acta 1993 Mar 20;1172(3):311-4.
4. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
5. Mitochondrial F(0)F(1) ATP synthase. Subunit regions on the F1 motor shielded by F(0), Functional significance, and evidence for an involvement of the unique F(0) subunit F(6). Ko YH, etal., J Biol Chem. 2000 Oct 20;275(42):32931-9.
6. Rat mitochondrial ATP synthase ATP5G3: cloning and upregulation in pancreas after chronic ethanol feeding. Li HS, etal., Physiol Genomics 2001 Jul 17;6(2):91-8.
7. Batten disease and the control of the Fo subunit c pore by cGMP and calcium. McGeoch JE and Guidotti G, Eur J Paediatr Neurol. 2001;5 Suppl A:147-50.
8. Identification of two proteins associated with mammalian ATP synthase. Meyer B, etal., Mol Cell Proteomics. 2007 Oct;6(10):1690-9. Epub 2007 Jun 17.
9. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
10. Local translation of ATP synthase subunit 9 mRNA alters ATP levels and the production of ROS in the axon. Natera-Naranjo O, etal., Mol Cell Neurosci. 2012 Mar;49(3):263-70. doi: 10.1016/j.mcn.2011.12.006. Epub 2011 Dec 21.
11. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
12. Inhibition of Bcl-xL prevents pro-death actions of ¿N-Bcl-xL at the mitochondrial inner membrane during glutamate excitotoxicity. Park HA, etal., Cell Death Differ. 2017 Nov;24(11):1963-1974. doi: 10.1038/cdd.2017.123. Epub 2017 Aug 4.
13. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
14. GOA pipeline RGD automated data pipeline
15. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
16. Comprehensive gene review and curation RGD comprehensive gene curation
17. Molecular cloning and expression of rat betacellulin cDNA. Tada H, etal., Biochim Biophys Acta 2000 Jun 21;1492(1):285-8.
18. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
Additional References at PubMed
PMID:12865426   PMID:14651853   PMID:16778019   PMID:18614015   PMID:22773120   PMID:23343770  


Genomics

Comparative Map Data
Atp5mc1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81081,520,762 - 81,523,735 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1081,520,765 - 81,523,363 (-)EnsemblGRCr8
mRatBN7.21081,024,056 - 81,026,780 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1081,024,064 - 81,026,284 (+)EnsemblmRatBN7.2
mRatBN7.2 Ensembl1081,023,925 - 81,027,124 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1085,972,277 - 85,974,869 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01085,470,315 - 85,472,907 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01080,863,050 - 80,865,635 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01083,895,941 - 83,898,640 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1083,895,947 - 83,898,527 (-)Ensemblrn6Rnor6.0
Rnor_5.01083,700,811 - 83,703,481 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41084,788,650 - 84,791,230 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1079,791,879 - 79,794,459 (-)NCBICelera
RGSC_v3.11084,803,019 - 84,805,600 (-)NCBI
Cytogenetic Map10q26NCBI
ATP5MC1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381748,892,787 - 48,895,871 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1748,892,765 - 48,895,875 (+)Ensemblhg38GRCh38
GRCh371746,970,149 - 46,973,233 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361744,325,147 - 44,328,232 (+)NCBIBuild 36Build 36hg18NCBI36
Build 341744,325,146 - 44,328,229NCBI
Celera1743,424,432 - 43,427,516 (+)NCBICelera
Cytogenetic Map17q21.32NCBI
HuRef1742,337,759 - 42,340,843 (+)NCBIHuRef
CHM1_11747,036,030 - 47,039,110 (+)NCBICHM1_1
T2T-CHM13v2.01749,756,527 - 49,759,610 (+)NCBIT2T-CHM13v2.0
Atp5mc1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391195,963,619 - 95,966,520 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1195,959,678 - 95,966,496 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381196,072,793 - 96,075,694 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1196,068,852 - 96,075,670 (-)Ensemblmm10GRCm38
MGSCv371195,934,107 - 95,937,008 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361195,884,942 - 95,891,127 (-)NCBIMGSCv36mm8
Celera11105,723,080 - 105,725,981 (-)NCBICelera
Cytogenetic Map11DNCBI
cM Map1159.33NCBI
Atp5mc1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545112,426,309 - 12,429,395 (-)Ensembl
ChiLan1.0NW_00495545112,426,309 - 12,429,460 (-)NCBIChiLan1.0ChiLan1.0
ATP5MC1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21916,207,230 - 16,210,352 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11718,172,819 - 18,175,941 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0178,641,273 - 8,644,395 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1178,828,117 - 8,831,213 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl178,828,117 - 8,831,190 (-)EnsemblpanPan2panpan1.1
ATP5MC1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1925,123,194 - 25,125,959 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl925,123,241 - 25,127,909 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha924,584,393 - 24,587,136 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0925,918,467 - 25,921,213 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl925,918,581 - 25,921,227 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1924,686,561 - 24,689,301 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0924,944,602 - 24,947,346 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0925,073,511 - 25,076,255 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Atp5mc1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560224,523,210 - 24,526,094 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493649012,548,813 - 12,552,278 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493649012,549,045 - 12,551,895 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ATP5MC1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1225,110,528 - 25,113,478 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11225,110,540 - 25,113,481 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21225,066,551 - 25,069,489 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ATP5MC1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11669,307,094 - 69,312,257 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1669,307,175 - 69,312,254 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366607740,408,597 - 40,411,665 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Atp5mc1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247955,297,161 - 5,301,746 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247955,297,475 - 5,300,526 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Atp5mc1
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1958,317,205 - 58,319,905 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Atp5mc1
26 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:81
Count of miRNA genes:69
Interacting mature miRNAs:75
Transcripts:ENSRNOT00000009815
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1549846Scl47Serum cholesterol level QTL 473.6blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)105107189796071897Rat
1298069Bp168Blood pressure QTL 1685.5blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)102702353598502431Rat
8657410Bp374Blood pressure QTL 374heart left ventricle size trait (VT:0002753)heart left ventricle end-diastolic diameter (CMO:0000982)1067476608107713808Rat
61449Ciaa2CIA Autoantibody QTL 27.1blood autoantibody amount (VT:0003725)calculated serum anti-type 2 collagen antibody titer (CMO:0001279)1063719161107713808Rat
631552Vetf2Vascular elastic tissue fragility QTL 24.50.0002aorta elastic tissue integrity trait (VT:0010556)artery internal elastic lamina non-tumorous lesion count (CMO:0001913)103550938391417879Rat
631555Bp134Blood pressure QTL 1340.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)108101207791729860Rat
61325Aia5Adjuvant induced arthritis QTL 50.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023948641107713808Rat
1298078Stresp5Stress response QTL 52.990.00025blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)1042546145107713808Rat
1549831Bss6Bone structure and strength QTL 64lumbar vertebra strength trait (VT:0010574)vertebra ultimate force (CMO:0001678)1058073360103073360Rat
12903252Cm113Cardiac mass QTL 1130.047heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)1066817119107713808Rat
70164Bw21Body weight QTL 214.360.00005body mass (VT:0001259)body weight (CMO:0000012)105429633699451733Rat
2298548Neuinf7Neuroinflammation QTL 73.4nervous system integrity trait (VT:0010566)spinal cord RT1-B protein level (CMO:0002132)1064939013107713808Rat
61463Bp12Blood pressure QTL 126.30.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)104183127886831278Rat
1302404Cia27Collagen induced arthritis QTL 272.60.0045joint integrity trait (VT:0010548)experimental arthritis severity measurement (CMO:0001459)1076951790107713808Rat
1579919Bp281Blood pressure QTL 2810.01arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)105046480295464802Rat
1300107Rf18Renal function QTL 183.41urine output (VT:0003620)timed urine volume (CMO:0000260)1079272424102982300Rat
70168Eae12Experimental allergic encephalomyelitis QTL 120.0009nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)1073599825107713808Rat
2300218Hpcl2Hepatic cholesterol level QTL 2liver cholesterol amount (VT:0010498)liver cholesterol level (CMO:0001597)104552916496099749Rat
8694173Bw149Body weight QTL 1494.380.001body mass (VT:0001259)body weight gain (CMO:0000420)104493935989939359Rat
70171Cari1Carrageenan-induced inflammation QTL 14.90.0005hypodermis integrity trait (VT:0010550)inflammatory exudate volume (CMO:0001429)1054296227107713808Rat
10450495Bp383Blood pressure QTL 3830.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)107674313395464802Rat
12903269Am15Aortic mass QTL 150.042aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)1066817119107713808Rat
10450493Bp382Blood pressure QTL 3820.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)105086028895860288Rat
12903266Cm114Cardiac mass QTL 1140.02heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)1066817119107713808Rat
61354Pia10Pristane induced arthritis QTL 100.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023948641107713808Rat
2292617Ept18Estrogen-induced pituitary tumorigenesis QTL 183.9pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)107395035396620293Rat
2301967Cm73Cardiac mass QTL 734.55heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)101499153586964295Rat
2313103Bss80Bone structure and strength QTL 8020.0001tibia strength trait (VT:1000284)tibia midshaft endosteal cross-sectional area (CMO:0001716)1062556066107556066Rat
70188BpQTLcluster1Blood pressure QTL cluster 14.864arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)14282327487823274Rat
724516Uae17Urinary albumin excretion QTL 173.6urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)107870758585720738Rat
70193Mcs7Mammary carcinoma susceptibility QTL 72.38mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1072724423107713808Rat
12880372Am12Aortic mass QTL 120.003aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)1066817119107713808Rat
2313105Bss79Bone structure and strength QTL 791.80.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)1062556066107556066Rat
12880375Kidm66Kidney mass QTL 660.009kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1066817119107713808Rat
1357344Bp249Blood pressure QTL 2490.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)106724133498502431Rat
9589030Epfw9Epididymal fat weight QTL 919.240.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)104493935989939359Rat
2316949Gluco60Glucose level QTL 603.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1014991535107556066Rat
12880370Cm105Cardiac mass QTL 1050.008heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)1066817119107713808Rat
70198BpQTLcluster9Blood pressure QTL cluster 92.94arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)104282327487823274Rat
12880371Cm106Cardiac mass QTL 1060.007heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)1066817119107713808Rat
2306970Anxrr22Anxiety related response QTL 225.95fear/anxiety-related behavior trait (VT:1000241)number of periods of voluntary immobility (CMO:0001045)106184349698710773Rat
1359017Hrtrt21Heart rate QTL 212.4heart pumping trait (VT:2000009)heart rate (CMO:0000002)107369533997272278Rat
11565453Kidm58Kidney mass QTL 580.002kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1066817119107713808Rat
7387312Bw125Body weight QTL 12530.0047retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight (CMO:0000356)1065390777107713808Rat
6893357Bw102Body weight QTL 1020.50.36body mass (VT:0001259)body weight (CMO:0000012)1081012077101828297Rat
724556Pur2Proteinuria QTL 25.5urine protein amount (VT:0005160)urine protein level (CMO:0000591)102293137391127454Rat
2306793Ean5Experimental allergic neuritis QTL 54.7nervous system integrity trait (VT:0010566)IFNG-secreting splenocyte count (CMO:0002122)107304965694495280Rat
2306792Ean4Experimental allergic neuritis QTL 44nervous system integrity trait (VT:0010566)IFNG-secreting splenocyte count (CMO:0002122)104949549294495492Rat
61387Bp1Blood pressure QTL 15.1arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1052269185107713808Rat
2317043Aia7Adjuvant induced arthritis QTL 73.82joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)107369533983061459Rat
2317042Aia20Adjuvant induced arthritis QTL 203.38joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)107369533983061459Rat
2298481Eau9Experimental allergic uveoretinitis QTL 90.0169uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)106413959783061459Rat
61396Bp9Blood pressure QTL 94.80.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1068920187107713808Rat
1358915Stresp7Stress response QTL 73.52blood norepinephrine amount (VT:0005663)plasma norepinephrine level (CMO:0001010)1065307813107713808Rat
70363Bp71Blood pressure QTL 710.04arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1061843496106843496Rat
61402Niddm3Non-insulin dependent diabetes mellitus QTL 34.58blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)106184363383061236Rat
1331791Cm31Cardiac mass QTL 313.84606heart mass (VT:0007028)heart wet weight (CMO:0000069)102980091091417879Rat
6893366Bw106Body weight QTL 1060.30.47body mass (VT:0001259)body weight (CMO:0000012)1070698731107713808Rat
631530Tls3T-lymphoma susceptibility QTL 300.0001thymus integrity trait (VT:0010555)percentage of study population developing T-cell lymphomas during a period of time (CMO:0001911)102758722696099902Rat
1354608Cm33Cardiac mass QTL 332.8heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)105530797293608131Rat
1558643Cm44Cardiac mass QTL 444.80.0000368heart mass (VT:0007028)heart wet weight (CMO:0000069)1061843496100198886Rat
8552805Bw145Body weight QTL 1452.2body mass (VT:0001259)change in body weight to body weight ratio (CMO:0002216)104360879388608793Rat
631267Cia20Collagen induced arthritis QTL 203.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023948641107713808Rat
631269Cia22Collagen induced arthritis QTL 228.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040535708107713808Rat
1576308Schws1Schwannoma susceptibility QTL 10.0041nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)1040535708107713808Rat
631268Cia21Collagen induced arthritis QTL 213.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1014991535107713808Rat
7207811Bmd90Bone mineral density QTL 905.2femur size trait (VT:1000369)femoral neck cross-sectional area (CMO:0001697)104994371094943710Rat
2325836Bp346Blood pressure QTL 3460.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)107674313384503487Rat
631270Cia23Collagen induced arthritis QTL 233.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040535708107713808Rat
1581559Eae18Experimental allergic encephalomyelitis QTL 180.00002nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis severity score (CMO:0001419)1066108888107555881Rat
7411614Foco18Food consumption QTL 180.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)104493935989939359Rat
6893336Cm75Cardiac mass QTL 750.10.87heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)1061843496100198886Rat
12880053Cm104Cardiac mass QTL 1040.009heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)107395020983959619Rat
631547Bp87Blood pressure QTL 874.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)104786912992869129Rat
61427Cia16Collagen induced arthritis QTL 163.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)10686461896620484Rat
2292438Bp311Blood pressure QTL 311arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)107674313395604677Rat
2292436Bp310Blood pressure QTL 310arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)105060467795604677Rat
12880050Am10Aortic mass QTL 100.016aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)103950348784503487Rat
1600367Mcs15Mammary carcinoma susceptibility QTL 154.5mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1072724423107713808Rat
6893342Cm78Cardiac mass QTL 780.10.88heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)103550938388177745Rat
631537Oia4Oil induced arthritis QTL 4joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1076128947107713808Rat
1358188Ept9Estrogen-induced pituitary tumorigenesis QTL 93.9pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)107395035396620293Rat
634354Rends3Renal damage susceptibility QTL 30.05kidney blood vessel morphology trait (VT:0000530)organ lesion measurement (CMO:0000677)1061997479106997479Rat
2301405Cm69Cardiac mass QTL 690.031heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)1066817119107713808Rat
631542Bp82Blood pressure QTL 826.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)102702353599451848Rat

Markers in Region
RH127939  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr81081,520,810 - 81,521,290 (+)Marker Load Pipeline
mRatBN7.21204,077,165 - 204,077,371 (+)MAPPERmRatBN7.2
mRatBN7.21081,024,105 - 81,024,585 (+)MAPPERmRatBN7.2
Rnor_6.01222,142,698 - 222,142,903NCBIRnor6.0
Rnor_6.01083,895,993 - 83,896,472NCBIRnor6.0
Rnor_5.01229,133,164 - 229,133,369UniSTSRnor5.0
Rnor_5.01083,700,863 - 83,701,342UniSTSRnor5.0
RGSC_v3.41209,560,365 - 209,560,570UniSTSRGSC3.4
RGSC_v3.41084,788,696 - 84,789,175UniSTSRGSC3.4
Celera1079,791,925 - 79,792,404UniSTS
Celera1201,611,163 - 201,611,368UniSTS
Cytogenetic Map1q43UniSTS
Cytogenetic Map10q31UniSTS
BI282209  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21081,024,112 - 81,024,585 (+)MAPPERmRatBN7.2
mRatBN7.21204,077,165 - 204,077,364 (+)MAPPERmRatBN7.2
Rnor_6.01222,142,698 - 222,142,896NCBIRnor6.0
Rnor_6.01083,896,000 - 83,896,472NCBIRnor6.0
Rnor_5.01083,700,870 - 83,701,342UniSTSRnor5.0
Rnor_5.01229,133,164 - 229,133,362UniSTSRnor5.0
RGSC_v3.41209,560,365 - 209,560,563UniSTSRGSC3.4
RGSC_v3.41084,788,703 - 84,789,175UniSTSRGSC3.4
Celera1079,791,932 - 79,792,404UniSTS
Celera1201,611,163 - 201,611,361UniSTS
Cytogenetic Map1q43UniSTS
Cytogenetic Map10q31UniSTS
SSO4H11  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21081,024,160 - 81,024,617 (+)MAPPERmRatBN7.2
mRatBN7.21204,077,133 - 204,077,316 (+)MAPPERmRatBN7.2
Rnor_6.01222,142,666 - 222,142,848NCBIRnor6.0
Rnor_6.01083,896,048 - 83,896,504NCBIRnor6.0
Rnor_5.01083,700,918 - 83,701,374UniSTSRnor5.0
Rnor_5.01229,133,132 - 229,133,314UniSTSRnor5.0
RGSC_v3.41209,560,333 - 209,560,515UniSTSRGSC3.4
RGSC_v3.41084,788,751 - 84,789,207UniSTSRGSC3.4
Celera1079,791,980 - 79,792,436UniSTS
Celera1201,611,131 - 201,611,313UniSTS
Cytogenetic Map1q43UniSTS
Cytogenetic Map10q31UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000009815   ⟹   ENSRNOP00000009815
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1081,520,765 - 81,523,363 (-)Ensembl
mRatBN7.2 Ensembl1081,024,064 - 81,026,284 (+)Ensembl
Rnor_6.0 Ensembl1083,895,947 - 83,898,527 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000096943
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1081,023,925 - 81,027,124 (-)Ensembl
RefSeq Acc Id: NM_017311   ⟹   NP_059007
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81081,520,765 - 81,523,345 (-)NCBI
mRatBN7.21081,024,060 - 81,026,640 (-)NCBI
Rnor_6.01083,895,947 - 83,898,527 (-)NCBI
Rnor_5.01083,700,811 - 83,703,481 (-)NCBI
RGSC_v3.41084,788,650 - 84,791,230 (-)RGD
Celera1079,791,879 - 79,794,459 (-)RGD
Sequence:
RefSeq Acc Id: XM_006247188   ⟹   XP_006247250
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81081,520,762 - 81,523,735 (-)NCBI
mRatBN7.21081,024,056 - 81,026,780 (-)NCBI
Rnor_6.01083,895,943 - 83,898,640 (-)NCBI
Rnor_5.01083,700,811 - 83,703,481 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006247189   ⟹   XP_006247251
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81081,520,762 - 81,523,378 (-)NCBI
mRatBN7.21081,024,056 - 81,026,705 (-)NCBI
Rnor_6.01083,895,941 - 83,898,546 (-)NCBI
Rnor_5.01083,700,811 - 83,703,481 (-)NCBI
Sequence:
RefSeq Acc Id: NP_059007   ⟸   NM_017311
- Peptide Label: precursor
- UniProtKB: Q06645 (UniProtKB/Swiss-Prot),   A6HID1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006247250   ⟸   XM_006247188
- Peptide Label: isoform X1
- UniProtKB: Q06645 (UniProtKB/Swiss-Prot),   A6HID1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006247251   ⟸   XM_006247189
- Peptide Label: isoform X1
- UniProtKB: Q06645 (UniProtKB/Swiss-Prot),   A6HID1 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000009815   ⟸   ENSRNOT00000009815
Protein Domains
V-ATPase proteolipid subunit C-like

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q06645-F1-model_v2 AlphaFold Q06645 1-136 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13697627
Promoter ID:EPDNEW_R8151
Type:initiation region
Name:Atp5mc1_1
Description:ATP synthase membrane subunit c locus 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01083,898,545 - 83,898,605EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:61933 AgrOrtholog
BioCyc Gene G2FUF-23519 BioCyc
BioCyc Pathway PWY-7980 [ATP biosynthesis] BioCyc
BioCyc Pathway Image PWY-7980 BioCyc
Ensembl Genes ENSRNOG00000007235 Ensembl, ENTREZGENE
  ENSRNOG00000069121 Ensembl
Ensembl Transcript ENSRNOT00000009815 ENTREZGENE
Gene3D-CATH 1.20.20.10 UniProtKB/Swiss-Prot
InterPro ATP_synth_F0_csu UniProtKB/Swiss-Prot
  ATP_synth_F0_csu_DDCD_BS UniProtKB/Swiss-Prot
  ATP_synth_F0_csu_sf UniProtKB/Swiss-Prot
  ATPase_proteolipid_c-like_dom UniProtKB/Swiss-Prot
  F/V-ATP_Csub_sf UniProtKB/Swiss-Prot
KEGG Report rno:29754 UniProtKB/Swiss-Prot
NCBI Gene 29754 ENTREZGENE
PANTHER ATP SYNTHASE F(0) COMPLEX SUBUNIT C2, MITOCHONDRIAL UniProtKB/Swiss-Prot
  PTHR10031 UniProtKB/Swiss-Prot
Pfam ATP-synt_C UniProtKB/Swiss-Prot
PhenoGen Atp5mc1 PhenoGen
PRINTS ATPASEC UniProtKB/Swiss-Prot
PROSITE ATPASE_C UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000007235 RatGTEx
  ENSRNOG00000069121 RatGTEx
RNAcentral URS00022B25D2 RNACentral
  URS00022B5CF3 RNACentral
Superfamily-SCOP SSF81333 UniProtKB/Swiss-Prot
TIGR TC204027
UniProt A6HID1 ENTREZGENE, UniProtKB/TrEMBL
  AT5G1_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2017-11-30 Atp5mc1  ATP synthase membrane subunit c locus 1  Atp5g1  ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C1 (subunit 9)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2011-12-01 Atp5g1  ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C1 (subunit 9)  Atp5g1  ATP synthase, H+ transporting, mitochondrial F0 complex, subunit C1 (subunit 9)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-06-27 Atp5g1  ATP synthase, H+ transporting, mitochondrial F0 complex, subunit C1 (subunit 9)  Atp5g1  ATP synthase, H+ transporting, mitochondrial F0 complex, subunit c (subunit 9), isoform 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-09-10 Atp5g1  ATP synthase, H+ transporting, mitochondrial F0 complex, subunit c (subunit 9), isoform 1    ATP synthase, H+ transporting, mitochondrial F0 complex, subunit c, isoform 1   Name updated 1299863 APPROVED
2002-06-10 Atp5g1  ATP synthase, H+ transporting, mitochondrial F0 complex, subunit c, isoform 1       Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference