Psmb4 (proteasome 20S subunit beta 4) - Rat Genome Database

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Gene: Psmb4 (proteasome 20S subunit beta 4) Rattus norvegicus
Analyze
Symbol: Psmb4
Name: proteasome 20S subunit beta 4
RGD ID: 61877
Description: Predicted to enable lipopolysaccharide binding activity. Predicted to be involved in negative regulation of inflammatory response to antigenic stimulus and proteasome-mediated ubiquitin-dependent protein catabolic process. Predicted to be located in ciliary basal body. Predicted to be part of proteasome core complex, beta-subunit complex. Predicted to be active in cytosol and nucleus. Human ortholog(s) of this gene implicated in proteasome-associated autoinflammatory syndrome 3. Orthologous to human PSMB4 (proteasome 20S subunit beta 4); PARTICIPATES IN ubiquitin/proteasome degradation pathway; INTERACTS WITH 1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane; 2,2',4,4'-Tetrabromodiphenyl ether; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: beta-7; macropain beta chain; multicatalytic endopeptidase complex beta chain; proteasome (prosome macropain) subunit beta type 4; proteasome (prosome, macropain) subunit, beta type 4; proteasome beta 4 subunit; proteasome beta chain; proteasome chain 3; proteasome subunit beta 4; proteasome subunit beta type-4; proteasome subunit beta-7; RN3
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82185,131,787 - 185,134,561 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl2185,131,786 - 185,135,287 (-)EnsemblGRCr8
mRatBN7.22182,442,757 - 182,445,532 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2182,442,756 - 182,445,746 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx2190,107,410 - 190,110,182 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02187,902,789 - 187,905,556 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02182,739,879 - 182,742,651 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.02196,043,546 - 196,046,320 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2196,043,618 - 196,046,311 (-)Ensemblrn6Rnor6.0
Rnor_5.02215,536,945 - 215,539,638 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.42189,778,476 - 189,781,169 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera2174,986,061 - 174,988,835 (-)NCBICelera
RGSC_v3.12189,732,542 - 189,735,229 (-)NCBI
Cytogenetic Map2q34NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (EXP)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
1H-pyrazole  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-trinitrotoluene  (EXP)
2,6-dimethoxyphenol  (ISO)
2-nitrofluorene  (EXP)
3H-1,2-dithiole-3-thione  (EXP,ISO)
4,4'-sulfonyldiphenol  (ISO)
4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one  (EXP)
4-nonylphenol  (ISO)
4-tert-Octylphenol  (ISO)
5-aza-2'-deoxycytidine  (ISO)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
aflatoxin B1  (EXP)
alpha-Zearalanol  (EXP)
aminoglutethimide  (ISO)
amitrole  (EXP)
ammonium chloride  (EXP)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenic trichloride  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
beta-lapachone  (ISO)
beta-naphthoflavone  (ISO)
bis(2-chloroethyl) sulfide  (EXP)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
buspirone  (EXP)
Butylbenzyl phthalate  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
carbon nanotube  (ISO)
carboplatin  (EXP)
cefaloridine  (EXP)
chloropicrin  (ISO)
cisplatin  (EXP)
clobetasol  (ISO)
clofibrate  (EXP,ISO)
cobalt dichloride  (ISO)
copper(II) sulfate  (ISO)
diarsenic trioxide  (ISO)
dibutyl phthalate  (ISO)
dichlorine  (EXP)
diclofenac  (EXP)
diethylstilbestrol  (EXP,ISO)
elemental selenium  (ISO)
finasteride  (EXP)
flavonoids  (EXP)
fluoxetine  (EXP)
flutamide  (EXP)
folic acid  (ISO)
furfural  (ISO)
gentamycin  (EXP)
hydrogen peroxide  (ISO)
ivermectin  (ISO)
leflunomide  (EXP)
lithocholic acid  (EXP)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
methapyrilene  (EXP)
methimazole  (EXP)
miconazole  (ISO)
microcystin RR  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-nitrosodimethylamine  (EXP)
nefazodone  (EXP)
nickel subsulfide  (EXP)
nimesulide  (EXP)
nitrates  (ISO)
nobiletin  (ISO)
Nonylphenol  (EXP)
ozone  (EXP)
p-tert-Amylphenol  (ISO)
paracetamol  (ISO)
pentachlorophenol  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP,ISO)
phenobarbital  (EXP)
PhIP  (EXP)
piperonyl butoxide  (EXP)
pirinixic acid  (EXP,ISO)
poly(propylene imine) macromolecule  (ISO)
pregnenolone 16alpha-carbonitrile  (EXP)
rotenone  (ISO)
selenium atom  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sodium chloride  (ISO)
stattic  (ISO)
sulfadimethoxine  (EXP)
sunitinib  (ISO)
tamoxifen  (ISO)
tetrachloromethane  (ISO)
titanium dioxide  (ISO)
triadimefon  (EXP)
trichostatin A  (ISO)
triphenyl phosphate  (ISO)
tungsten  (ISO)
valdecoxib  (EXP)
valproic acid  (EXP)
vinclozolin  (EXP)
vitamin E  (ISO)
vorinostat  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
4. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
5. GOA pipeline RGD automated data pipeline
6. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
7. An abundance of free regulatory (19S) proteasome particles regulates neuronal synapses. Sun C, etal., Science. 2023 May 26;380(6647):eadf2018. doi: 10.1126/science.adf2018. Epub 2023 May 26.
8. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
9. cDNA cloning of a new type of subunit of mammalian proteasomes. Thomson S, etal., FEBS Lett 1993 May 10;322(2):135-8.
Additional References at PubMed
PMID:2335214   PMID:8645151   PMID:12874245   PMID:16857966   PMID:17323924   PMID:20458337   PMID:20498273   PMID:21630459   PMID:22793692   PMID:26524591   PMID:27514644   PMID:31505169  
PMID:32651614   PMID:33954843  


Genomics

Comparative Map Data
Psmb4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82185,131,787 - 185,134,561 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl2185,131,786 - 185,135,287 (-)EnsemblGRCr8
mRatBN7.22182,442,757 - 182,445,532 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2182,442,756 - 182,445,746 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx2190,107,410 - 190,110,182 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02187,902,789 - 187,905,556 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02182,739,879 - 182,742,651 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.02196,043,546 - 196,046,320 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2196,043,618 - 196,046,311 (-)Ensemblrn6Rnor6.0
Rnor_5.02215,536,945 - 215,539,638 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.42189,778,476 - 189,781,169 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera2174,986,061 - 174,988,835 (-)NCBICelera
RGSC_v3.12189,732,542 - 189,735,229 (-)NCBI
Cytogenetic Map2q34NCBI
PSMB4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381151,399,573 - 151,401,937 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1151,399,556 - 151,401,941 (+)Ensemblhg38GRCh38
GRCh371151,372,049 - 151,374,413 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361149,638,665 - 149,641,036 (+)NCBIBuild 36Build 36hg18NCBI36
Build 341148,185,113 - 148,187,485NCBI
Celera1124,487,307 - 124,489,678 (+)NCBICelera
Cytogenetic Map1q21.3NCBI
HuRef1122,750,051 - 122,752,422 (+)NCBIHuRef
CHM1_11152,767,631 - 152,770,002 (+)NCBICHM1_1
T2T-CHM13v2.01150,523,282 - 150,525,646 (+)NCBIT2T-CHM13v2.0
Psmb4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39394,791,635 - 94,794,269 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl394,791,404 - 94,794,272 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38394,884,324 - 94,886,958 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl394,884,093 - 94,886,961 (-)Ensemblmm10GRCm38
MGSCv37394,688,246 - 94,690,880 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36394,969,728 - 94,972,336 (-)NCBIMGSCv36mm8
Celera396,315,024 - 96,317,658 (-)NCBICelera
Cytogenetic Map3F2.1NCBI
cM Map340.74NCBI
Psmb4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955589976,321 - 978,617 (-)Ensembl
ChiLan1.0NW_004955589976,216 - 978,566 (-)NCBIChiLan1.0ChiLan1.0
PSMB4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2198,421,766 - 98,424,410 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1198,172,938 - 98,175,321 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01126,758,604 - 126,760,989 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11130,404,234 - 130,406,638 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1130,404,234 - 130,406,638 (+)EnsemblpanPan2panpan1.1
PSMB4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11760,461,208 - 60,463,604 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1760,461,240 - 60,463,594 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1759,904,234 - 59,906,625 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01761,477,234 - 61,479,628 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1761,477,244 - 61,479,618 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11760,305,058 - 60,307,449 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01760,391,008 - 60,393,402 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01761,119,636 - 61,122,029 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Psmb4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505822,580,235 - 22,582,975 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365801,609,775 - 1,618,175 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365801,610,635 - 1,613,357 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PSMB4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl497,835,547 - 97,837,921 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1497,835,544 - 97,837,909 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.24107,036,322 - 107,038,687 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PSMB4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12012,291,727 - 12,294,120 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2012,291,070 - 12,294,311 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366603811,866,110 - 11,868,521 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Psmb4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462477219,124,386 - 19,126,627 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462477219,124,327 - 19,126,731 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Psmb4
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1362,368,058 - 62,370,782 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Psmb4
12 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:85
Count of miRNA genes:72
Interacting mature miRNAs:76
Transcripts:ENSRNOT00000028484
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1358356Srcrt1Stress Responsive Cort QTL13.66blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)2163997722225110681Rat
1578648Bss11Bone structure and strength QTL 114.7femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)2169358774214358774Rat
1331734Bp204Blood pressure QTL 2043.61192arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2170656145239614549Rat
631566Bp90Blood pressure QTL 900.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2149957381221199885Rat
1298074Bp164Blood pressure QTL 1640.003arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)244537979205135428Rat
1354648Bp239Blood pressure QTL 2390.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)267845370229470703Rat
1354649Kidm17Kidney mass QTL 172.9kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)283465462229820014Rat
10755499Bp389Blood pressure QTL 3892.61arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)220695736231474293Rat
1298076Bp166Blood pressure QTL 1660.0009arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2138595962205135428Rat
1581576Pur7Proteinuria QTL 70.0001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)280396178220931218Rat
152025245Scl81Serum cholesterol level QTL 813.49blood cholesterol amount (VT:0000180)2124537199209621565Rat
1581578Cm49Cardiac mass QTL 494.90.01heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)2145807215220931416Rat
631198Cm22Cardiac mass QTL 224.30.0008heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)278269809208420281Rat
1554319Bmd2Bone mineral density QTL 213.40.0001lumbar vertebra area (VT:0010570)lumbar vertebra cross-sectional area (CMO:0001689)2122597372215234002Rat
12879836Kidm61Kidney mass QTL 610.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)2154723085199723085Rat
1581569Uae32Urinary albumin excretion QTL 320.0001urine protein amount (VT:0005160)urine albumin excretion rate (CMO:0000757)280396178220931218Rat
10043136Iddm54Insulin dependent diabetes mellitus QTL 543.40.0001blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)2145807215190807215Rat
12879837Am2Aortic mass QTL 20.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)2154723085199723085Rat
10043139Iddm55Insulin dependent diabetes mellitus QTL 553.10.0001blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)2150313808195313808Rat
12879838Cm86Cardiac mass QTL 860.002heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)2154723085199723085Rat
1302793Bw16Body weight QTL 1650.0001body mass (VT:0001259)body weight (CMO:0000012)2159440891205135267Rat
12879839Cm85Cardiac mass QTL 850.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)2154723085199723085Rat
1549833Bp257Blood pressure QTL 2570.003arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2170652929215652929Rat
1358900Bw48Body weight QTL 484.88body mass (VT:0001259)body weight (CMO:0000012)2159440891220931218Rat
4889834Pur24Proteinuria QTL 245.80.014urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)2171994826205135428Rat
1359030Bp277Blood pressure QTL 277arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)2143565208188565208Rat
1331760Bp206Blood pressure QTL 2063.62454arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)24265106205135428Rat
12879840Bw179Body weight QTL 1790.005body mass (VT:0001259)body weight (CMO:0000012)2154723085199723085Rat
1581502Esta3Estrogen-induced thymic atrophy QTL 3thymus mass (VT:0004954)thymus wet weight (CMO:0000855)2139067258192287892Rat
9589044Scfw1Subcutaneous fat weight QTL 15.80.001subcutaneous adipose mass (VT:1000472)abdominal subcutaneous fat pad weight (CMO:0002069)2184856304229856304Rat
8694435Bw166Body weight QTL 16614.080.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)2184856304229856304Rat
1359032Hrtrt18Heart rate QTL 18heart pumping trait (VT:2000009)heart rate (CMO:0000002)2159440760195313808Rat
2301966Bp322Blood pressure QTL 3223.58arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2144882354205135428Rat
1298080Bp163Blood pressure QTL 1630.02arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)267845182205135428Rat
1357991Ael2Aortic elastin QTL 24.20.000071aorta elastin amount (VT:0003905)aortic elastin2169227906214227906Rat
8662832Vetf7Vascular elastic tissue fragility QTL 73.5aorta elastin amount (VT:0003905)aorta wall extracellular elastin dry weight to aorta wall dry weight ratio (CMO:0002002)283400752223709938Rat
1298085Bp165Blood pressure QTL 1650.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)244537979205135428Rat
8694194Abfw1Abdominal fat weight QTL 111.70.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)2184856304229856304Rat
1578671Bmd10Bone mineral density QTL 105.4femur mineral mass (VT:0010011)compact volumetric bone mineral density (CMO:0001730)2175931416220931416Rat
1641891Alcrsp17Alcohol response QTL 17response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)2151869660251712708Rat
724534Uae6Urinary albumin excretion QTL 610urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)280396034220931416Rat
61374Edpm2Estrogen-dependent pituitary mass QTL 24.420.86pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)278269809205135428Rat
2300189Bmd48Bone mineral density QTL 485.80.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)2182024327227024327Rat
8662843Vetf9Vascular elastic tissue fragility QTL 92.05thoracic aorta molecular composition trait (VT:0010568)aorta wall extracellular elastin dry weight to aorta wall extracellular collagen weight ratio (CMO:0002003)2159440760228950743Rat
2301408Kidm36Kidney mass QTL 360.002kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)2184482291229482291Rat
1331794Bp202Blood pressure QTL 2023.66819arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2143344967251712708Rat
71113Cari2Carrageenan-induced inflammation QTL 22.70.009hypodermis integrity trait (VT:0010550)inflammatory exudate volume (CMO:0001429)2143746578205135428Rat
1331805Cm29Cardiac mass QTL 293.50746heart mass (VT:0007028)heart wet weight (CMO:0000069)2143344967251712708Rat
634308Sach6Saccharin preference QTL 64.9taste sensitivity trait (VT:0001986)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)2114384617215381366Rat
1598805Memor8Memory QTL 83exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)2150096616195096616Rat
1358917Cm42Cardiac mass QTL 422.82heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)227148328206613235Rat
724568Uae13Urinary albumin excretion QTL 134.4urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)2145306936212705578Rat
1358913Cm41Cardiac mass QTL 412.73heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)227148328206613235Rat
1300165Rf9Renal function QTL 93.28kidney glomerulus integrity trait (VT:0010546)index of glomerular damage (CMO:0001135)2113746222205135428Rat
61401Niddm2Non-insulin dependent diabetes mellitus QTL 24.54blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)2147287892192287892Rat
631507Bp105Blood pressure QTL 1050.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2114384617215381366Rat
1641925Alcrsp2Alcohol response QTL 2response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)2151869660223841096Rat
1354609Niddm62Non-insulin dependent diabetes mellitus QTL 624.720.000006insulin secretion trait (VT:0003564)plasma insulin level (CMO:0000342)2117415288205135428Rat
1598833Bp295Blood pressure QTL 2953.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2150096616195096616Rat
61417Cia10Collagen induced arthritis QTL 103.4joint integrity trait (VT:0010548)experimental arthritis severity measurement (CMO:0001459)2182635347227635347Rat
1354622Kidm16Kidney mass QTL 163kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)283465462225110681Rat
631266Bp132Blood pressure QTL 1320.0005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)247856345205135428Rat
631522Bp74Blood pressure QTL 740.05arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2175008837220008837Rat
8694383Bw158Body weight QTL 1587.690.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)2184856304229856304Rat
7488927Bp365Blood pressure QTL 3650.008arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2165453811210453811Rat
7488925Bp364Blood pressure QTL 3640.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2163253030208253030Rat
2306901Bp337Blood pressure QTL 3370.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2166372086229820014Rat
1354605Rf48Renal function QTL 482.9blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)276328396209350714Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_031629 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC130969 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH474015 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ215475 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ216787 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218364 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219781 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ220578 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ220909 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ223788 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ225189 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ226073 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ226711 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ227250 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ228014 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ231402 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ232850 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000002 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  L17127 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000028484   ⟹   ENSRNOP00000028484
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl2185,131,786 - 185,135,287 (-)Ensembl
mRatBN7.2 Ensembl2182,442,756 - 182,445,746 (-)Ensembl
Rnor_6.0 Ensembl2196,043,618 - 196,046,311 (-)Ensembl
RefSeq Acc Id: NM_031629   ⟹   NP_113817
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82185,131,787 - 185,134,561 (-)NCBI
mRatBN7.22182,442,757 - 182,445,532 (-)NCBI
Rnor_6.02196,043,546 - 196,046,320 (-)NCBI
Rnor_5.02215,536,945 - 215,539,638 (-)NCBI
RGSC_v3.42189,778,476 - 189,781,169 (-)RGD
Celera2174,986,061 - 174,988,835 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_113817 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA42054 (Get FASTA)   NCBI Sequence Viewer  
  EDL85768 (Get FASTA)   NCBI Sequence Viewer  
  P34067 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_113817   ⟸   NM_031629
- UniProtKB: P97719 (UniProtKB/Swiss-Prot),   P34067 (UniProtKB/Swiss-Prot),   P28071 (UniProtKB/Swiss-Prot),   A6K2T2 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000028484   ⟸   ENSRNOT00000028484

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P34067-F1-model_v2 AlphaFold P34067 1-263 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13691532
Promoter ID:EPDNEW_R2057
Type:multiple initiation site
Name:Psmb4_1
Description:proteasome subunit beta 4
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.02196,046,311 - 196,046,371EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:61877 AgrOrtholog
BioCyc Gene G2FUF-52146 BioCyc
Ensembl Genes ENSRNOG00000020979 Ensembl
Gene3D-CATH 3.60.20.10 UniProtKB/Swiss-Prot
InterPro Ntn_hydrolases_N UniProtKB/Swiss-Prot
  Proteasome_beta4 UniProtKB/Swiss-Prot
  Proteasome_bsu_CS UniProtKB/Swiss-Prot
  Proteasome_sua/b UniProtKB/Swiss-Prot
  Proteasome_suB-type UniProtKB/Swiss-Prot
NCBI Gene 58854 ENTREZGENE
PANTHER METALLOPROTEASE TLDD UniProtKB/Swiss-Prot
  PROTEASOME SUBUNIT BETA UniProtKB/Swiss-Prot
Pfam Proteasome UniProtKB/Swiss-Prot
PhenoGen Psmb4 PhenoGen
PIRSF Psome_endopept_beta UniProtKB/Swiss-Prot
PROSITE PROTEASOME_BETA_1 UniProtKB/Swiss-Prot
  PROTEASOME_BETA_2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000020979 RatGTEx
Superfamily-SCOP SSF56235 UniProtKB/Swiss-Prot
TIGR TC204347
UniProt A6K2T2 ENTREZGENE, UniProtKB/TrEMBL
  G3V8U9_RAT UniProtKB/TrEMBL
  P28071 ENTREZGENE
  P34067 ENTREZGENE
  P97719 ENTREZGENE
  PSB4_RAT UniProtKB/Swiss-Prot
UniProt Secondary P28071 UniProtKB/Swiss-Prot
  P97719 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-09-13 Psmb4  proteasome 20S subunit beta 4  Psmb4  proteasome subunit beta 4  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2015-08-19 Psmb4  proteasome subunit beta 4  Psmb4  proteasome (prosome, macropain) subunit, beta type 4  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Psmb4  proteasome (prosome, macropain) subunit, beta type 4      Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference