Clic4 (chloride intracellular channel 4) - Rat Genome Database

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Gene: Clic4 (chloride intracellular channel 4) Rattus norvegicus
Analyze
Symbol: Clic4
Name: chloride intracellular channel 4
RGD ID: 61857
Description: Enables chloride channel activity. Predicted to be involved in several processes, including cellular response to calcium ion; chloride transport; and keratinocyte differentiation. Predicted to act upstream of or within several processes, including endothelial cell morphogenesis; vacuolar acidification; and vasculature development. Located in mitochondrial outer membrane. Orthologous to human CLIC4 (chloride intracellular channel 4); INTERACTS WITH 17alpha-ethynylestradiol; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: chloride intracellular channel 4 (mitochondrial); chloride intracellular channel protein 4; glutaredoxin-like oxidoreductase CLIC4; intracellular chloride ion channel protein p64H1; mitochondrial chloride intracellular channel 4
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85152,737,371 - 152,797,118 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl5152,737,371 - 152,797,118 (-)EnsemblGRCr8
mRatBN7.25147,453,702 - 147,513,455 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5147,453,712 - 147,513,452 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx5150,157,499 - 150,214,039 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05151,928,975 - 151,985,428 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05151,913,767 - 151,970,313 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.05153,568,937 - 153,625,669 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5153,568,745 - 153,625,869 (-)Ensemblrn6Rnor6.0
Rnor_5.05157,338,299 - 157,394,464 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.45154,005,244 - 154,066,883 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera5145,866,637 - 145,923,113 (-)NCBICelera
RGSC_v3.15154,015,282 - 154,076,922 (-)NCBI
Cytogenetic Map5q36NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,6-dimethoxyphenol  (ISO)
2-butoxyethanol  (ISO)
2-methylcholine  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
6-propyl-2-thiouracil  (EXP)
acrylamide  (EXP,ISO)
all-trans-retinoic acid  (ISO)
ammonium chloride  (EXP)
antimycin A  (ISO)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
benzo[a]pyrene  (ISO)
Benzo[ghi]perylene  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
bleomycin A2  (EXP)
butanal  (ISO)
cadmium dichloride  (ISO)
carbon nanotube  (ISO)
chloroprene  (EXP)
choline  (ISO)
cisplatin  (ISO)
clozapine  (ISO)
cobalt dichloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
cyclophosphamide  (ISO)
cyclosporin A  (ISO)
DDE  (ISO)
deguelin  (ISO)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
dibutyl phthalate  (ISO)
Didecyldimethylammonium  (ISO)
diuron  (EXP,ISO)
dorsomorphin  (ISO)
entinostat  (ISO)
enzyme inhibitor  (ISO)
ethanol  (ISO)
fenpyroximate  (ISO)
fenvalerate  (EXP)
flavonoids  (EXP)
folic acid  (ISO)
furfural  (ISO)
gemcitabine  (ISO)
genistein  (EXP)
gentamycin  (EXP)
graphite  (EXP)
hydrogen peroxide  (ISO)
Indeno[1,2,3-cd]pyrene  (ISO)
indometacin  (ISO)
inulin  (ISO)
ivermectin  (ISO)
L-methionine  (ISO)
lipopolysaccharide  (ISO)
mercury dichloride  (ISO)
methamphetamine  (EXP)
methyl methanesulfonate  (ISO)
Methylazoxymethanol acetate  (EXP)
methylmercury chloride  (ISO)
methylmercury(1+)  (ISO)
microcystin RR  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
nickel atom  (ISO)
nickel sulfate  (ISO)
nitrates  (ISO)
nitrofen  (EXP)
Nivalenol  (ISO)
obeticholic acid  (ISO)
ochratoxin A  (ISO)
okadaic acid  (ISO)
ozone  (ISO)
paracetamol  (EXP,ISO)
pentachlorophenol  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
phenobarbital  (ISO)
phenylephrine  (EXP)
picoxystrobin  (ISO)
progesterone  (ISO)
propiconazole  (ISO)
pyrimidifen  (ISO)
raloxifene  (ISO)
rimonabant  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (EXP,ISO)
sodium chloride  (ISO)
Soman  (EXP)
streptozocin  (ISO)
testosterone enanthate  (ISO)
tetrachloromethane  (ISO)
thifluzamide  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
tributylstannane  (ISO)
Tributyltin oxide  (ISO)
trichloroethene  (ISO)
trichostatin A  (ISO)
triphenyl phosphate  (ISO)
undecane  (EXP)
valproic acid  (ISO)
vorinostat  (ISO)
zinc atom  (EXP)
zinc(0)  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Identification of a novel member of the chloride intracellular channel gene family (CLIC5) that associates with the actin cytoskeleton of placental microvilli. Berryman M and Bretscher A, Mol Biol Cell. 2000 May;11(5):1509-21.
2. Rat brain p64H1, expression of a new member of the p64 chloride channel protein family in endoplasmic reticulum. Duncan RR, etal., J Biol Chem 1997 Sep 19;272(38):23880-6.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
5. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
6. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
7. Molecular identity of cardiac mitochondrial chloride intracellular channel proteins. Ponnalagu D, etal., Mitochondrion. 2016 Mar;27:6-14. doi: 10.1016/j.mito.2016.01.001. Epub 2016 Jan 9.
8. Overexpressed chloride intracellular channel protein CLIC4 (p64H1) is an essential component of novel plasma membrane anion channels. Proutski I, etal., Biochem Biophys Res Commun 2002 Sep 20;297(2):317-22.
9. GOA pipeline RGD automated data pipeline
10. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
11. Chloride intracellular channel protein CLIC4 (p64H1) binds directly to brain dynamin I in a complex containing actin, tubulin and 14-3-3 isoforms. Suginta W, etal., Biochem J. 2001 Oct 1;359(Pt 1):55-64.
12. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
Additional References at PubMed
PMID:10026142   PMID:10593946   PMID:12163372   PMID:14569596   PMID:14651853   PMID:17453412   PMID:17636002   PMID:18302930   PMID:18614015   PMID:19056867   PMID:19197003   PMID:19776349  
PMID:20458337   PMID:20610659   PMID:22871113   PMID:23376485   PMID:24503951   PMID:29131056   PMID:29518790  


Genomics

Comparative Map Data
Clic4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85152,737,371 - 152,797,118 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl5152,737,371 - 152,797,118 (-)EnsemblGRCr8
mRatBN7.25147,453,702 - 147,513,455 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5147,453,712 - 147,513,452 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx5150,157,499 - 150,214,039 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05151,928,975 - 151,985,428 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05151,913,767 - 151,970,313 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.05153,568,937 - 153,625,669 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5153,568,745 - 153,625,869 (-)Ensemblrn6Rnor6.0
Rnor_5.05157,338,299 - 157,394,464 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.45154,005,244 - 154,066,883 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera5145,866,637 - 145,923,113 (-)NCBICelera
RGSC_v3.15154,015,282 - 154,076,922 (-)NCBI
Cytogenetic Map5q36NCBI
CLIC4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38124,745,447 - 24,844,321 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl124,745,342 - 24,844,321 (+)Ensemblhg38GRCh38
GRCh37125,071,938 - 25,170,812 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36124,944,435 - 25,043,346 (+)NCBIBuild 36Build 36hg18NCBI36
Build 34124,817,153 - 24,916,064NCBI
Celera123,398,865 - 23,495,461 (+)NCBICelera
Cytogenetic Map1p36.11NCBI
HuRef123,328,646 - 23,424,410 (+)NCBIHuRef
CHM1_1125,184,596 - 25,284,364 (+)NCBICHM1_1
T2T-CHM13v2.0124,582,409 - 24,679,995 (+)NCBIT2T-CHM13v2.0
Clic4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394134,941,280 - 135,000,071 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl4134,941,280 - 135,000,125 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm384135,213,969 - 135,272,760 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4135,213,969 - 135,272,814 (-)Ensemblmm10GRCm38
MGSCv374134,769,884 - 134,828,675 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv364134,486,045 - 134,544,836 (-)NCBIMGSCv36mm8
Celera4133,399,961 - 133,460,231 (-)NCBICelera
Cytogenetic Map4D3NCBI
cM Map467.19NCBI
Clic4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554524,479,783 - 4,534,115 (+)Ensembl
ChiLan1.0NW_0049554524,479,783 - 4,534,115 (+)NCBIChiLan1.0ChiLan1.0
CLIC4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21202,090,577 - 202,186,135 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11201,191,251 - 201,289,737 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0123,947,030 - 24,042,139 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1124,975,304 - 25,017,904 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl124,975,260 - 25,017,904 (+)EnsemblpanPan2panpan1.1
CLIC4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1274,903,653 - 74,974,103 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl274,906,948 - 74,974,032 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha271,477,775 - 71,548,015 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0275,465,388 - 75,535,965 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl275,465,443 - 75,535,994 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1272,288,187 - 72,358,703 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0273,294,973 - 73,365,679 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0274,299,369 - 74,369,911 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Clic4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505843,846,369 - 43,886,310 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364749,681,878 - 9,707,810 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049364749,664,872 - 9,711,036 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CLIC4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl682,401,188 - 82,483,724 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1682,401,041 - 82,483,038 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2676,224,518 - 76,244,851 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CLIC4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.120107,855,046 - 107,952,529 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_0236660338,406,443 - 8,502,483 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Clic4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247649,088,352 - 9,149,194 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Clic4
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1122,945,564 - 23,005,162 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Clic4
407 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:285
Count of miRNA genes:204
Interacting mature miRNAs:229
Transcripts:ENSRNOT00000024464
Prediction methods:Miranda
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1331796Thshl2Thyroid stimulating hormone level QTL 22.3blood thyroid-stimulating hormone amount (VT:0005119)serum thyroid stimulating hormone level (CMO:0001248)5102105698152749382Rat
10053720Scort26Serum corticosterone level QTL 262.060.0147blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)5130249266172190305Rat
1549845Scl44Serum cholesterol level QTL 446blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)544924861153890773Rat
8552960Pigfal15Plasma insulin-like growth factor 1 level QTL 15blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)5116702075161702075Rat
1354583Despr3Despair related QTL34.980.0002locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)5132930505172190305Rat
61444Strs2Sensitivity to stroke QTL 24.7cerebrum integrity trait (VT:0010549)post-insult time to onset of cerebrovascular lesion (CMO:0002343)5141212838172190305Rat
1300119Bp180Blood pressure QTL 1803.82arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)5149642129171146538Rat
61452Ciaa5CIA Autoantibody QTL 53.5blood autoantibody amount (VT:0003725)calculated serum anti-rat type 2 collagen autoantibody titer (CMO:0001281)599905133172190305Rat
70156Niddm30Non-insulin dependent diabetes mellitus QTL 303.98blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)5134369218156289444Rat
8552908Pigfal4Plasma insulin-like growth factor 1 level QTL 46.6blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)5133789363172190305Rat
1331803Rf32Renal function QTL 322.798kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)5134369199172190305Rat
61393Bp7Blood pressure QTL 74.50.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)565089051166764498Rat
7794791Mcs33Mammary carcinoma susceptibility QTL 331.93mammary gland integrity trait (VT:0010552)mammary tumor incidence/prevalence measurement (CMO:0000946)5136631198172190305Rat
7207486Bss109Bone structure and strength QTL 109femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)5112142946157142946Rat
7207481Bss106Bone structure and strength QTL 1067.9femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)5112142946157142946Rat
1302790Scl20Serum cholesterol level QTL 206.40.0001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)5110770739155770739Rat
1598861Cm64Cardiac mass QTL 642.9heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)5133081618172190305Rat
1578766Tcas11Tongue tumor susceptibility QTL 114.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)551657967166600247Rat
631263Cm24Cardiac mass QTL 243.5heart mass (VT:0007028)heart left ventricle weight to body weight ratio (CMO:0000530)5149805999162987697Rat
631505Bp103Blood pressure QTL 1033.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5138002522170842766Rat
1549838Bss4Bone structure and strength QTL 49.2femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)5112142946157142946Rat
1581505Rf54Renal function QTL 54kidney physiology trait (VT:0002136)kidney 20-HETE level (CMO:0001854)5133270647172190305Rat
2317753Glom24Glomerulus QTL 243.1kidney glomerulus integrity trait (VT:0010546)kidney sclerotic glomeruli count to total glomeruli count ratio (CMO:0001269)5141764300172190305Rat
8694169Bw148Body weight QTL 14850.001body mass (VT:0001259)body weight gain (CMO:0000420)5133789363172190305Rat
1331721Bp210Blood pressure QTL 2103.413arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)5148093485172129029Rat
1581510Cm54Cardiac mass QTL 543.40.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)5125969677172190305Rat
1576312Emca8Estrogen-induced mammary cancer QTL 84.1mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)555124766172190305Rat
2317056Wbc3White blood cell count QTL 32.510.01leukocyte quantity (VT:0000217)white blood cell count (CMO:0000027)5111236572156236572Rat
724525Bp147Blood pressure QTL 1474.30.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5131708216172190305Rat
1598847Cm62Cardiac mass QTL 623.4heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)5114131300159131300Rat
2293642Bss37Bone structure and strength QTL 374.640.0001femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)5125969677156302135Rat
2313096Bmd78Bone mineral density QTL 783.10.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)5149661912166600247Rat
7207488Bss110Bone structure and strength QTL 18.4femur strength trait (VT:0010010)femur stiffness (CMO:0001674)5112142946157142946Rat
8694441Bw169Body weight QTL 16917.610.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)5116702075161702075Rat
7207491Bss112Bone structure and strength QTL 1127femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)5112142946157142946Rat
8694389Bw160Body weight QTL 1606.170.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)5116702075161702075Rat
1354598Srn6Serum renin concentration QTL 63.8blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)574335621156302135Rat
8694198Abfw3Abdominal fat weight QTL 316.130.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)5116702075161702075Rat
1298089Scl14Serum cholesterol level QTL 145.80.0004blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)5114131300159131300Rat
1598819Bp292Blood pressure QTL 2924.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5133081618172190305Rat
1358187Emca1Estrogen-induced mammary cancer QTL 14.4mammary gland integrity trait (VT:0010552)post-insult time to mammary tumor formation (CMO:0000345)5104262817153890625Rat

Markers in Region
D5Rat93  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr85152,749,151 - 152,749,382 (+)Marker Load Pipeline
mRatBN7.25147,465,483 - 147,465,714 (+)MAPPERmRatBN7.2
Rnor_6.05153,577,601 - 153,577,831NCBIRnor6.0
Rnor_5.05157,346,963 - 157,347,193UniSTSRnor5.0
RGSC_v3.45154,013,908 - 154,014,139RGDRGSC3.4
RGSC_v3.45154,013,909 - 154,014,139UniSTSRGSC3.4
Celera5145,875,300 - 145,875,530UniSTS
RGSC_v3.15154,023,948 - 154,024,178RGD
RH 3.4 Map5999.4RGD
RH 3.4 Map5999.4UniSTS
RH 2.0 Map5939.3RGD
SHRSP x BN Map585.2699RGD
FHH x ACI Map583.1599RGD
Cytogenetic Map5q36UniSTS
D5Uwm3  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25147,489,702 - 147,489,865 (+)MAPPERmRatBN7.2
mRatBN7.267,017,967 - 7,018,606 (-)MAPPERmRatBN7.2
Rnor_6.0611,150,950 - 11,151,587NCBIRnor6.0
Rnor_6.05153,601,801 - 153,601,963NCBIRnor6.0
Rnor_5.05157,370,596 - 157,370,758UniSTSRnor5.0
Rnor_5.0621,137,478 - 21,138,115UniSTSRnor5.0
RGSC_v3.4611,059,388 - 11,060,026UniSTSRGSC3.4
RGSC_v3.45154,043,309 - 154,043,471UniSTSRGSC3.4
Celera66,769,186 - 6,769,824UniSTS
Celera5145,899,540 - 145,899,702UniSTS
RGSC_v3.15154,053,347 - 154,053,510RGD
Cytogenetic Map5q36UniSTS
RH127750  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr85152,737,490 - 152,737,708 (+)Marker Load Pipeline
mRatBN7.25147,453,821 - 147,454,039 (+)MAPPERmRatBN7.2
Rnor_6.05153,565,940 - 153,566,157NCBIRnor6.0
Rnor_5.05157,335,302 - 157,335,519UniSTSRnor5.0
RGSC_v3.45154,002,247 - 154,002,464UniSTSRGSC3.4
Celera5145,863,640 - 145,863,857UniSTS
RH 3.4 Map5999.4UniSTS
Cytogenetic Map5q36UniSTS
RH130462  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25147,455,218 - 147,455,399 (+)MAPPERmRatBN7.2
Rnor_6.05153,567,337 - 153,567,517NCBIRnor6.0
Rnor_5.05157,336,699 - 157,336,879UniSTSRnor5.0
RGSC_v3.45154,003,644 - 154,003,824UniSTSRGSC3.4
Celera5145,865,037 - 145,865,217UniSTS
RH 3.4 Map5997.7UniSTS
Cytogenetic Map5q36UniSTS
RH140130  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25147,455,152 - 147,455,335 (+)MAPPERmRatBN7.2
Rnor_6.05153,567,271 - 153,567,453NCBIRnor6.0
Rnor_5.05157,336,633 - 157,336,815UniSTSRnor5.0
RGSC_v3.45154,003,578 - 154,003,760UniSTSRGSC3.4
Celera5145,864,971 - 145,865,153UniSTS
Cytogenetic Map5q36UniSTS
RH140995  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25147,456,341 - 147,456,553 (+)MAPPERmRatBN7.2
Rnor_6.05153,568,460 - 153,568,671NCBIRnor6.0
Rnor_5.05157,337,822 - 157,338,033UniSTSRnor5.0
RGSC_v3.45154,004,767 - 154,004,978UniSTSRGSC3.4
Celera5145,866,160 - 145,866,371UniSTS
RH 3.4 Map5999.4UniSTS
Cytogenetic Map5q36UniSTS
AW532625  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25147,457,412 - 147,457,563 (+)MAPPERmRatBN7.2
Rnor_6.05153,569,531 - 153,569,681NCBIRnor6.0
Rnor_5.05157,338,893 - 157,339,043UniSTSRnor5.0
RGSC_v3.45154,005,838 - 154,005,988UniSTSRGSC3.4
Celera5145,867,231 - 145,867,381UniSTS
RH 3.4 Map5999.4UniSTS
Cytogenetic Map5q36UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000024464   ⟹   ENSRNOP00000024464
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl5152,737,371 - 152,797,118 (-)Ensembl
mRatBN7.2 Ensembl5147,453,712 - 147,513,452 (-)Ensembl
Rnor_6.0 Ensembl5153,568,745 - 153,625,869 (-)Ensembl
RefSeq Acc Id: NM_031818   ⟹   NP_114006
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85152,737,371 - 152,797,118 (-)NCBI
mRatBN7.25147,453,702 - 147,513,455 (-)NCBI
Rnor_6.05153,568,937 - 153,625,669 (-)NCBI
Rnor_5.05157,338,299 - 157,394,464 (-)NCBI
RGSC_v3.45154,005,244 - 154,066,883 (-)RGD
Celera5145,866,637 - 145,923,113 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_114006 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAD16875 (Get FASTA)   NCBI Sequence Viewer  
  ABN51165 (Get FASTA)   NCBI Sequence Viewer  
  EDL80749 (Get FASTA)   NCBI Sequence Viewer  
  EDL80750 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000024464
GenBank Protein Q9Z0W7 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_114006   ⟸   NM_031818
- UniProtKB: Q9Z0W7 (UniProtKB/Swiss-Prot),   G3V8C4 (UniProtKB/TrEMBL),   A6IT49 (UniProtKB/TrEMBL),   A3FM27 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000024464   ⟸   ENSRNOT00000024464
Protein Domains
GST C-terminal

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9Z0W7-F1-model_v2 AlphaFold Q9Z0W7 1-253 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13694151
Promoter ID:EPDNEW_R4675
Type:multiple initiation site
Name:Clic4_1
Description:chloride intracellular channel 4
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.05153,625,846 - 153,625,906EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:61857 AgrOrtholog
BioCyc Gene G2FUF-39549 BioCyc
Ensembl Genes ENSRNOG00000018109 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000024464 ENTREZGENE
Gene3D-CATH 1.20.1050.10 UniProtKB/Swiss-Prot
  Glutaredoxin UniProtKB/Swiss-Prot
InterPro CLIC UniProtKB/Swiss-Prot
  CLIC_N UniProtKB/Swiss-Prot
  Glutathione-S-Trfase_C-like UniProtKB/Swiss-Prot
  Glutathione-S-Trfase_C_sf UniProtKB/Swiss-Prot
  Glutathione_S-Trfase UniProtKB/Swiss-Prot
  Thioredoxin-like_sf UniProtKB/Swiss-Prot
KEGG Report rno:83718 UniProtKB/Swiss-Prot
NCBI Gene 83718 ENTREZGENE
PANTHER CHLORIDE INTRACELLULAR CHANNEL PROTEIN UniProtKB/Swiss-Prot
  CHLORIDE INTRACELLULAR CHANNEL PROTEIN 6-RELATED UniProtKB/Swiss-Prot
Pfam CLIC-like_N UniProtKB/Swiss-Prot
  GST_C_2 UniProtKB/Swiss-Prot
PhenoGen Clic4 PhenoGen
PRINTS INTCLCHANNEL UniProtKB/Swiss-Prot
PROSITE GST_CTER UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000018109 RatGTEx
Superfamily-SCOP SSF47616 UniProtKB/Swiss-Prot
  SSF52833 UniProtKB/Swiss-Prot
TIGR TC234480
UniProt A3FM27 ENTREZGENE, UniProtKB/TrEMBL
  A6IT48_RAT UniProtKB/TrEMBL
  A6IT49 ENTREZGENE, UniProtKB/TrEMBL
  CLIC4_RAT UniProtKB/Swiss-Prot
  G3V8C4 ENTREZGENE, UniProtKB/TrEMBL
  Q9Z0W7 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2009-11-05 Clic4  chloride intracellular channel 4  Clic4  chloride intracellular channel 4 (mitochondrial)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-02-18 Clic4  chloride intracellular channel 4 (mitochondrial)  Clic4  chloride intracellular channel 4  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Clic4  chloride intracellular channel 4      Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_cellular_localization localized to the plasma membrane 632350
gene_cellular_localization C-terminus of the integral membrane form is cytoplasmic 632350
gene_cellular_localization localized to endoplasmic reticulum 61554