Foxm1 (forkhead box M1) - Rat Genome Database

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Gene: Foxm1 (forkhead box M1) Rattus norvegicus
Analyze
Symbol: Foxm1
Name: forkhead box M1
RGD ID: 61807
Description: Enables sequence-specific DNA binding activity. Involved in response to cAMP and response to gonadotropin. Predicted to be active in nucleus. Orthologous to human FOXM1 (forkhead box M1); INTERACTS WITH 1-naphthyl isothiocyanate; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: forkhead box protein M1; INS-1 winged helix; winged-helix factor from INS-1 cells
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84163,325,628 - 163,338,100 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl4163,325,614 - 163,337,172 (+)EnsemblGRCr8
mRatBN7.24161,639,538 - 161,652,012 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4161,638,816 - 161,650,684 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx4167,869,266 - 167,880,288 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04163,652,202 - 163,663,224 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04162,286,242 - 162,297,264 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.04161,685,236 - 161,697,633 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4161,685,258 - 161,696,305 (+)Ensemblrn6Rnor6.0
Rnor_5.04226,891,344 - 226,903,694 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.44165,383,666 - 165,394,688 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera4150,341,256 - 150,352,278 (+)NCBICelera
RGSC_v3.14165,628,601 - 165,639,621 (+)NCBI
Cytogenetic Map4q42NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,1-dichloroethene  (ISO)
1,2,4-trichloro-5-(2,5-dichlorophenyl)benzene  (ISO)
1,2-dimethylhydrazine  (ISO)
1-naphthyl isothiocyanate  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,4'-trichlorobiphenyl  (ISO)
2,4-dinitrotoluene  (EXP)
2,6-di-tert-butyl-4-methylphenol  (ISO)
2-palmitoylglycerol  (ISO)
3',4',5-trihydroxy-3,7-dimethoxyflavone  (ISO)
3',5'-cyclic AMP  (ISO)
3-methylcholanthrene  (ISO)
4-hydroxynon-2-enal  (ISO)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
acrylamide  (ISO)
aflatoxin B1  (ISO)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (ISO)
androstane  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
azathioprine  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
berberine  (ISO)
beta-carotene  (ISO)
beta-lapachone  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bisphenol A  (EXP,ISO)
Butylbenzyl phthalate  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
calcitriol  (ISO)
carbon nanotube  (ISO)
cerium trichloride  (ISO)
CGP 52608  (ISO)
chenodeoxycholic acid  (ISO)
choline  (ISO)
chromium(6+)  (ISO)
cisplatin  (ISO)
citraconic acid  (ISO)
cobalt dichloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
coumarin  (ISO)
coumestrol  (ISO)
Cuprizon  (EXP)
cyclosporin A  (ISO)
D-glucose  (ISO)
diallyl trisulfide  (ISO)
diarsenic trioxide  (ISO)
diazinon  (ISO)
dibutyl phthalate  (EXP,ISO)
dichloroacetic acid  (ISO)
dicrotophos  (ISO)
diminazene diaceturate  (ISO)
dioxygen  (EXP)
diquat  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
Enterolactone  (ISO)
fipronil  (EXP)
folic acid  (ISO)
FR900359  (ISO)
fulvestrant  (ISO)
gentamycin  (EXP)
geraniol  (ISO)
glucose  (ISO)
guggulsterone  (ISO)
GW 7647  (ISO)
harmine  (ISO)
hydrogen peroxide  (ISO)
L-ascorbic acid  (ISO)
L-methionine  (ISO)
lanthanum trichloride  (ISO)
lead(0)  (ISO)
lipopolysaccharide  (ISO)
lucanthone  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
menadione  (ISO)
methotrexate  (ISO)
miconazole  (ISO)
microcystin-LR  (ISO)
N-acetyl-L-cysteine  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-nitrosodiethylamine  (ISO)
niclosamide  (ISO)
nitrogen dioxide  (ISO)
obeticholic acid  (ISO)
okadaic acid  (ISO)
oxaliplatin  (EXP)
ozone  (ISO)
palbociclib  (ISO)
paracetamol  (EXP,ISO)
paraquat  (ISO)
PCB138  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctanoic acid  (ISO)
phenethyl isothiocyanate  (ISO)
phenobarbital  (ISO)
phytoestrogen  (ISO)
pirinixic acid  (ISO)
piroxicam  (ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
propanal  (ISO)
propiconazole  (ISO)
quercetin  (ISO)
reactive oxygen species  (ISO)
resveratrol  (ISO)
silicon dioxide  (ISO)
Siomycin A  (ISO)
sirolimus  (ISO)
sodium arsenite  (ISO)
Soman  (EXP)
sulindac sulfide  (ISO)
sunitinib  (ISO)
tamoxifen  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (ISO)
tetrachloromethane  (EXP,ISO)
thioacetamide  (EXP)
thiostrepton  (ISO)
thiram  (ISO)
titanium dioxide  (ISO)
topotecan  (EXP)
trichloroethene  (ISO)
trimellitic anhydride  (ISO)
triptonide  (ISO)
troglitazone  (ISO)
trovafloxacin  (ISO)
tungsten  (ISO)
tunicamycin  (ISO)
urethane  (ISO)
valproic acid  (ISO)
vitamin E  (ISO)
Yangonin  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (ISO)
nucleolus  (IEA,ISO)
nucleoplasm  (IEA,ISO)
nucleus  (IBA,IEA,ISO)

References

References - curated
# Reference Title Reference Citation
1. Role of winged helix transcription factor (WIN) in the regulation of Sertoli cell differentiated functions: WIN acts as an early event gene for follicle-stimulating hormone. Chaudhary J, etal., Endocrinology. 2000 Aug;141(8):2758-66.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. The FOXM1-induced resistance to oxaliplatin is partially mediated by its novel target gene Mcl-1 in gastric cancer cells. Hu CJ, etal., Biochim Biophys Acta. 2015 Mar;1849(3):290-9. doi: 10.1016/j.bbagrm.2014.11.008. Epub 2014 Dec 4.
4. Down-regulation of microRNA-494 via loss of SMAD4 increases FOXM1 and β-catenin signaling in pancreatic ductal adenocarcinoma cells. Li L, etal., Gastroenterology. 2014 Aug;147(2):485-97.e18. doi: 10.1053/j.gastro.2014.04.048. Epub 2014 May 20.
5. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
6. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
7. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
8. Comprehensive gene review and curation RGD comprehensive gene curation
9. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
10. Molecular analysis of a novel winged helix protein, WIN. Expression pattern, DNA binding property, and alternative splicing within the DNA binding domain. Yao KM, etal., J Biol Chem 1997 Aug 8;272(32):19827-36.
11. Gestational diabetes mellitus resulting from impaired beta-cell compensation in the absence of FoxM1, a novel downstream effector of placental lactogen. Zhang H, etal., Diabetes. 2010 Jan;59(1):143-52. Epub 2009 Oct 15.
Additional References at PubMed
PMID:8889548   PMID:9032290   PMID:10523841   PMID:15531365   PMID:15817462   PMID:17101782   PMID:17261592   PMID:19160488   PMID:19696738   PMID:20531406   PMID:21860419   PMID:23152492  
PMID:23386122   PMID:24194502   PMID:24478626   PMID:29290032   PMID:29848205   PMID:30669752   PMID:36107242   PMID:38338955  


Genomics

Comparative Map Data
Foxm1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84163,325,628 - 163,338,100 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl4163,325,614 - 163,337,172 (+)EnsemblGRCr8
mRatBN7.24161,639,538 - 161,652,012 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4161,638,816 - 161,650,684 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx4167,869,266 - 167,880,288 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04163,652,202 - 163,663,224 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04162,286,242 - 162,297,264 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.04161,685,236 - 161,697,633 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4161,685,258 - 161,696,305 (+)Ensemblrn6Rnor6.0
Rnor_5.04226,891,344 - 226,903,694 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.44165,383,666 - 165,394,688 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera4150,341,256 - 150,352,278 (+)NCBICelera
RGSC_v3.14165,628,601 - 165,639,621 (+)NCBI
Cytogenetic Map4q42NCBI
FOXM1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38122,857,680 - 2,877,174 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl122,857,676 - 2,877,174 (-)Ensemblhg38GRCh38
GRCh37122,966,846 - 2,986,340 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36122,837,110 - 2,856,564 (-)NCBIBuild 36Build 36hg18NCBI36
Celera124,580,805 - 4,600,257 (-)NCBICelera
Cytogenetic Map12p13.33NCBI
HuRef122,824,362 - 2,843,552 (-)NCBIHuRef
CHM1_1122,966,095 - 2,985,580 (-)NCBICHM1_1
T2T-CHM13v2.0122,863,691 - 2,883,185 (-)NCBIT2T-CHM13v2.0
Foxm1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm396128,339,957 - 128,352,849 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl6128,339,930 - 128,353,109 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm386128,362,994 - 128,375,886 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl6128,362,967 - 128,376,146 (+)Ensemblmm10GRCm38
MGSCv376128,313,012 - 128,325,904 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv366128,328,595 - 128,341,501 (+)NCBIMGSCv36mm8
Celera6130,039,894 - 130,052,715 (+)NCBICelera
Cytogenetic Map6F3NCBI
cM Map662.98NCBI
Foxm1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542918,393,470 - 18,405,254 (-)Ensembl
ChiLan1.0NW_00495542918,392,545 - 18,405,254 (-)NCBIChiLan1.0ChiLan1.0
FOXM1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2108,407,936 - 8,428,504 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1128,404,695 - 8,425,266 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0122,978,400 - 2,999,077 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1122,910,028 - 2,930,503 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl122,910,028 - 2,930,503 (-)EnsemblpanPan2panpan1.1
FOXM1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12741,894,605 - 41,905,656 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2741,894,672 - 41,905,663 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha274,778,534 - 4,791,647 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.02742,250,470 - 42,263,807 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2742,252,557 - 42,262,817 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12742,192,286 - 42,205,394 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02742,161,889 - 42,175,002 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0274,138,252 - 4,151,367 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Foxm1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404945105,982,169 - 105,999,205 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366063,185,982 - 3,198,378 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049366063,185,289 - 3,198,427 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
FOXM1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl567,263,117 - 67,270,949 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1 Ensembl567,245,694 - 67,263,211 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1567,246,219 - 67,263,215 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2569,532,909 - 69,549,908 (+)NCBISscrofa10.2Sscrofa10.2susScr3
FOXM1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1112,920,903 - 2,941,011 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl112,920,663 - 2,940,823 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_0236660635,375,678 - 5,395,462 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Foxm1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624860207,242 - 219,959 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_004624860206,367 - 222,035 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Foxm1
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1619,325,199 - 19,337,537 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Foxm1
97 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:571
Count of miRNA genes:178
Interacting mature miRNAs:206
Transcripts:ENSRNOT00000008003, ENSRNOT00000008012, ENSRNOT00000048415
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
6478754Anxrr43Anxiety related response QTL 430.14035locomotor behavior trait (VT:0001392)distance moved per unit of time into, out of or within a discrete space in an experimental apparatus (CMO:0001493)4146370897184426481Rat
724558Plsm2Polydactyly-luxate syndrome (PLS) morphotypes QTL 20.0003hindlimb integrity trait (VT:0010563)hind foot phalanges count (CMO:0001949)4134095016179095016Rat
1582237Kidm34Kidney mass QTL 3440.0001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)4149763204169799698Rat
6478757Anxrr44Anxiety related response QTL 440.01087locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4155834926184426481Rat
6478693Anxrr32Anxiety related response QTL 320.00092locomotor behavior trait (VT:0001392)measurement of voluntary locomotion into, out of or within a discrete space in an experimental apparatus (CMO:0000957)4146370897184426481Rat
1358364Sradr4Stress Responsive Adrenal Weight QTL 44.92adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)4131384565176384565Rat
10755501Bp390Blood pressure QTL 3902.5arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)427730518170099664Rat
61451Ciaa4CIA Autoantibody QTL 43.1blood autoantibody amount (VT:0003725)calculated serum anti-rat type 2 collagen autoantibody titer (CMO:0001281)4123870974168870974Rat
1331738Bp209Blood pressure QTL 2092.979arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)4140059299181024663Rat
6478700Anxrr33Anxiety related response QTL 330.00896locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4146370897184426481Rat
1298524Oia8Oil induced arthritis QTL 8joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4140059299184426481Rat
10053718Scort25Serum corticosterone level QTL 252.150.0097blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)4157292416184426481Rat
738009Sach4Saccharine consumption QTL 44.90.000016consumption behavior trait (VT:0002069)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)460916264184426481Rat
737821Hcar9Hepatocarcinoma resistance QTL 93.7liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)4106848959168870974Rat
634335Anxrr16Anxiety related response QTL 167.22locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)494638356168870820Rat
7411558Bw133Body weight QTL 13313.840.001body mass (VT:0001259)body weight gain (CMO:0000420)4127263297172263297Rat
6478778Anxrr51Anxiety related response QTL 510.25384locomotor behavior trait (VT:0001392)measurement of voluntary locomotion into, out of or within a discrete space in an experimental apparatus (CMO:0000957)4126334185171334185Rat
10401796Kidm48Kidney mass QTL 48kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)4147299608184426481Rat
6478718Anxrr34Anxiety related response QTL 340.00896locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4146370897184426481Rat
6478782Anxrr52Anxiety related response QTL 520.02091locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4155834926184426481Rat
631511Pia7Pristane induced arthritis QTL 74.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4123870974168870974Rat
634347Hcar8Hepatocarcinoma resistance QTL 85.8liver integrity trait (VT:0010547)liver tumorous lesion area to total liver area ratio (CMO:0001075)4124700988169700988Rat
6478720Alc23Alcohol consumption QTL 230.00509drinking behavior trait (VT:0001422)ethanol drink intake rate to body weight ratio (CMO:0001616)4155834926184426481Rat
6478785Anxrr53Anxiety related response QTL 530.01397locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4155834926184426481Rat
738031Alc14Alcohol consumption QTL 147.60.00003consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)460916264174095838Rat
1576316Ept5Estrogen-induced pituitary tumorigenesis QTL 53.8pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)4100752691179366077Rat
1581566Eae21Experimental allergic encephalomyelitis QTL 216.2body mass (VT:0001259)maximum body weight loss to initial body weight ratio (CMO:0001400)4137447185182447185Rat
1578674Bmd12Bone mineral density QTL 123.8femur mineral mass (VT:0010011)compact volumetric bone mineral density (CMO:0001730)4137430611182430611Rat
6478728Anxrr36Anxiety related response QTL 360.01061locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4155834926184426481Rat
738016Alc16Alcohol consumption QTL 163.60.00015consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)460916264184426481Rat
1358202Gluco11Glucose level QTL 112.40.02adipocyte glucose uptake trait (VT:0004185)absolute change in adipocyte glucose uptake (CMO:0000873)486709649168870974Rat
61422Cia13Collagen induced arthritis QTL 134.5joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4134199006168870974Rat
634342Cia24Collagen induced arthritis QTL 244.5joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4148121375176967367Rat
6478733Anxrr37Anxiety related response QTL 370.00095locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4155834926184426481Rat
737978Pia23Pristane induced arthritis QTL 235.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4123870974168870974Rat
61362Oia2Oil induced arthritis QTL 20.001joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4140059299184426481Rat
6478737Anxrr38Anxiety related response QTL 380.00159locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4155834926184426481Rat
2293659Bmd35Bone mineral density QTL 354.50.0001femur strength trait (VT:0010010)femoral neck ultimate force (CMO:0001703)4160623982184426481Rat
2316958Gluco58Glucose level QTL 5810blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)412212457182430611Rat
6478748Anxrr42Anxiety related response QTL 420.28008locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4146370897184426481Rat
12798525Anxrr57Anxiety related response QTL 573.210.05locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4148834094168870974Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 160 91 90 59 91 59 6 355 191 11 139 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000008003   ⟹   ENSRNOP00000008003
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl4163,325,750 - 163,336,772 (+)Ensembl
mRatBN7.2 Ensembl4161,639,660 - 161,650,684 (+)Ensembl
Rnor_6.0 Ensembl4161,685,283 - 161,696,305 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000008012   ⟹   ENSRNOP00000008012
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl4163,325,628 - 163,337,172 (+)Ensembl
mRatBN7.2 Ensembl4161,638,816 - 161,650,684 (+)Ensembl
Rnor_6.0 Ensembl4161,685,258 - 161,695,513 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000110534   ⟹   ENSRNOP00000088409
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl4163,325,614 - 163,336,949 (+)Ensembl
mRatBN7.2 Ensembl4161,638,816 - 161,650,684 (+)Ensembl
RefSeq Acc Id: NM_001413985   ⟹   NP_001400914
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84163,325,628 - 163,338,100 (+)NCBI
mRatBN7.24161,639,538 - 161,652,012 (+)NCBI
RefSeq Acc Id: NM_031633   ⟹   NP_113821
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84163,325,750 - 163,336,772 (+)NCBI
mRatBN7.24161,639,660 - 161,650,684 (+)NCBI
Rnor_6.04161,685,283 - 161,696,305 (+)NCBI
Rnor_5.04226,891,344 - 226,903,694 (+)NCBI
RGSC_v3.44165,383,666 - 165,394,688 (+)RGD
Celera4150,341,256 - 150,352,278 (+)RGD
Sequence:
RefSeq Acc Id: XM_006237416   ⟹   XP_006237478
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84163,325,651 - 163,338,100 (+)NCBI
mRatBN7.24161,639,561 - 161,652,012 (+)NCBI
Rnor_6.04161,685,236 - 161,697,633 (+)NCBI
Rnor_5.04226,891,344 - 226,903,694 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006237418   ⟹   XP_006237480
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84163,325,651 - 163,338,100 (+)NCBI
mRatBN7.24161,639,561 - 161,652,012 (+)NCBI
Rnor_6.04161,685,236 - 161,697,633 (+)NCBI
Rnor_5.04226,891,344 - 226,903,694 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006237419   ⟹   XP_006237481
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84163,325,651 - 163,338,100 (+)NCBI
mRatBN7.24161,639,561 - 161,652,012 (+)NCBI
Rnor_6.04161,685,236 - 161,697,633 (+)NCBI
Rnor_5.04226,891,344 - 226,903,694 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006237420   ⟹   XP_006237482
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84163,325,651 - 163,338,100 (+)NCBI
mRatBN7.24161,639,561 - 161,652,012 (+)NCBI
Rnor_6.04161,685,236 - 161,697,633 (+)NCBI
Rnor_5.04226,891,344 - 226,903,694 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006237421   ⟹   XP_006237483
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84163,325,651 - 163,338,100 (+)NCBI
mRatBN7.24161,639,561 - 161,652,012 (+)NCBI
Rnor_6.04161,685,236 - 161,697,633 (+)NCBI
Rnor_5.04226,891,344 - 226,903,694 (+)NCBI
Sequence:
RefSeq Acc Id: NP_113821   ⟸   NM_031633
- Peptide Label: isoform 2
- UniProtKB: D3ZLE1 (UniProtKB/TrEMBL),   A6IM05 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006237478   ⟸   XM_006237416
- Peptide Label: isoform X1
- UniProtKB: P97691 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006237481   ⟸   XM_006237419
- Peptide Label: isoform X4
- UniProtKB: P97691 (UniProtKB/Swiss-Prot),   A0A8I6A7T5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006237480   ⟸   XM_006237418
- Peptide Label: isoform X2
- UniProtKB: P97691 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006237483   ⟸   XM_006237421
- Peptide Label: isoform X3
- UniProtKB: P97691 (UniProtKB/Swiss-Prot),   A6IM06 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006237482   ⟸   XM_006237420
- Peptide Label: isoform X5
- UniProtKB: P97691 (UniProtKB/Swiss-Prot)
- Sequence:
Ensembl Acc Id: ENSRNOP00000008012   ⟸   ENSRNOT00000008012
Ensembl Acc Id: ENSRNOP00000008003   ⟸   ENSRNOT00000008003
Ensembl Acc Id: ENSRNOP00000088409   ⟸   ENSRNOT00000110534
RefSeq Acc Id: NP_001400914   ⟸   NM_001413985
- Peptide Label: isoform 1
- UniProtKB: P97691 (UniProtKB/Swiss-Prot),   F1LN13 (UniProtKB/TrEMBL)
Protein Domains
Fork-head

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P97691-F1-model_v2 AlphaFold P97691 1-759 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13693425
Promoter ID:EPDNEW_R3947
Type:initiation region
Name:Foxm1_2
Description:forkhead box M1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R3948  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.04161,685,161 - 161,685,221EPDNEW
RGD ID:13693423
Promoter ID:EPDNEW_R3948
Type:multiple initiation site
Name:Foxm1_1
Description:forkhead box M1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R3947  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.04161,685,285 - 161,685,345EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:61807 AgrOrtholog
BioCyc Gene G2FUF-42862 BioCyc
Ensembl Genes ENSRNOG00000005936 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000008003 ENTREZGENE
  ENSRNOT00000008012 ENTREZGENE
  ENSRNOT00000110534 ENTREZGENE
Gene3D-CATH 1.10.10.10 UniProtKB/Swiss-Prot
InterPro FH_FOXM1 UniProtKB/Swiss-Prot
  Fork_head_dom UniProtKB/Swiss-Prot
  FOXM1 UniProtKB/Swiss-Prot
  TF_fork_head_CS_1 UniProtKB/Swiss-Prot
  TF_fork_head_CS_2 UniProtKB/Swiss-Prot
  WH-like_DNA-bd_sf UniProtKB/Swiss-Prot
  WH_DNA-bd_sf UniProtKB/Swiss-Prot
NCBI Gene 58921 ENTREZGENE
PANTHER FORKHEAD BOX PROTEIN M1 UniProtKB/Swiss-Prot
  PTHR46878 UniProtKB/Swiss-Prot
Pfam Forkhead UniProtKB/Swiss-Prot
PhenoGen Foxm1 PhenoGen
PRINTS FORKHEAD UniProtKB/Swiss-Prot
PROSITE FORK_HEAD_1 UniProtKB/Swiss-Prot
  FORK_HEAD_2 UniProtKB/Swiss-Prot
  FORK_HEAD_3 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000005936 RatGTEx
SMART SM00339 UniProtKB/Swiss-Prot
Superfamily-SCOP SSF46785 UniProtKB/Swiss-Prot
TIGR TC234183
UniProt A0A8I6A7T5 ENTREZGENE, UniProtKB/TrEMBL
  A6IM05 ENTREZGENE, UniProtKB/TrEMBL
  A6IM06 ENTREZGENE, UniProtKB/TrEMBL
  D3ZLE1 ENTREZGENE, UniProtKB/TrEMBL
  F1LN13 ENTREZGENE, UniProtKB/TrEMBL
  FOXM1_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-06-10 Foxm1  forkhead box M1      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_domains DNA binding domain is encoded by four exons 728214
gene_expression mRNA expressed in thymus, testis, lung and intestine 728214
gene_transcript two exons (4 and 6) are alternatively spliced; may generate at least 3 classes of alternative mRNA transcripts 728214