Yes1 (YES proto-oncogene 1, Src family tyrosine kinase) - Rat Genome Database

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Gene: Yes1 (YES proto-oncogene 1, Src family tyrosine kinase) Rattus norvegicus
Analyze
Symbol: Yes1
Name: YES proto-oncogene 1, Src family tyrosine kinase
RGD ID: 3977
Description: Enables epidermal growth factor receptor binding activity and protein tyrosine kinase activity. Predicted to be involved in cell differentiation and cell surface receptor protein tyrosine kinase signaling pathway. Predicted to act upstream of or within several processes, including cellular response to platelet-derived growth factor stimulus; cellular response to retinoic acid; and cellular response to transforming growth factor beta stimulus. Is active in glutamatergic synapse and postsynaptic specialization, intracellular component. Orthologous to human YES1 (YES proto-oncogene 1, Src family tyrosine kinase); PARTICIPATES IN eicosanoid signaling pathway; ephrin - ephrin receptor bidirectional signaling axis; glypican signaling pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; aflatoxin B1; ammonium chloride.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: c-Yes; LOC363300; MGC94936; p60c-yes; p61-Yes; tyrosine-protein kinase Yes; Yamagichi sarcoma viral (v-yes-1) oncogene homolog 1; Yamaguchi sarcoma viral (v-yes) oncogene homolog; Yamaguchi sarcoma viral (v-yes) oncogene homolog 1; Yamaguchi sarcoma viral oncogene homolog 1; Yes
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr89120,646,657 - 120,753,880 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl9120,646,838 - 120,746,441 (+)EnsemblGRCr8
mRatBN7.29113,200,256 - 113,275,942 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl9113,200,256 - 113,299,837 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx9121,684,273 - 121,760,004 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.09126,813,413 - 126,889,144 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.09125,159,312 - 125,235,046 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.09121,802,471 - 121,918,906 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl9121,802,673 - 121,902,678 (+)Ensemblrn6Rnor6.0
Rnor_5.09121,252,194 - 121,327,422 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.49112,516,831 - 112,564,072 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera9110,304,110 - 110,380,060 (+)NCBICelera
Cytogenetic Map9q38NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
(S)-nicotine  (ISO)
1,2-dimethylhydrazine  (ISO)
2,3',4,4',5-Pentachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-tribromophenol  (ISO)
2,6-dimethoxyphenol  (ISO)
2-bromohexadecanoic acid  (ISO)
2-deoxy-D-glucose  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxynon-2-enal  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-fluorouracil  (ISO)
acrolein  (ISO)
aflatoxin B1  (EXP,ISO)
alpha-pinene  (ISO)
ammonium chloride  (EXP)
antimycin A  (ISO)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
benzo[a]pyrene  (ISO)
benzo[e]pyrene  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
bleomycin A2  (ISO)
bortezomib  (ISO)
C60 fullerene  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
caffeine  (ISO)
CGP 52608  (ISO)
chromium(6+)  (ISO)
cisplatin  (ISO)
cobalt dichloride  (ISO)
decabromodiphenyl ether  (ISO)
diarsenic trioxide  (ISO)
dibenzo[a,l]pyrene  (ISO)
dibutyl phthalate  (ISO)
ethanol  (ISO)
formaldehyde  (ISO)
furfural  (ISO)
HC toxin  (ISO)
hydrogen peroxide  (ISO)
irinotecan  (ISO)
ivermectin  (ISO)
methapyrilene  (ISO)
nicotine  (ISO)
Nor-9-carboxy-delta9-THC  (ISO)
ozone  (ISO)
paracetamol  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phenobarbital  (ISO)
pirinixic acid  (ISO)
ponatinib  (ISO)
quercetin  (ISO)
SB 431542  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenite  (EXP,ISO)
sodium chloride  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
trimellitic anhydride  (ISO)
triphenyl phosphate  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Identification of autophosphorylation sites in c-Yes purified from rat liver plasma membranes. Ariki M, etal., J Biochem (Tokyo) 1997 Jan;121(1):104-11.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. Interactions between Src family protein tyrosine kinases and PSD-95. Kalia LV and Salter MW, Neuropharmacology. 2003 Nov;45(6):720-8.
5. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
6. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
7. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
8. GOA pipeline RGD automated data pipeline
9. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
10. Caveolin-1 facilitates mechanosensitive protein kinase B (Akt) signaling in vitro and in vivo. Sedding DG, etal., Circ Res. 2005 Apr 1;96(6):635-42. Epub 2005 Feb 24.
11. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
12. A kinase cascade leading to Rab11-FIP5 controls transcytosis of the polymeric immunoglobulin receptor. Su T, etal., Nat Cell Biol. 2010 Dec;12(12):1143-53. Epub 2010 Oct 31.
13. MicroRNA-140 attenuates myocardial ischemia-reperfusion injury through suppressing mitochondria-mediated apoptosis by targeting YES1. Yang S, etal., J Cell Biochem. 2019 Mar;120(3):3813-3821. doi: 10.1002/jcb.27663. Epub 2018 Sep 27.
Additional References at PubMed
PMID:1381360   PMID:9799234   PMID:10861086   PMID:11448999   PMID:11546805   PMID:12496267   PMID:12538589   PMID:12923167   PMID:14634819   PMID:15039424   PMID:16921024   PMID:17623777  
PMID:18682436   PMID:18697750   PMID:19199708   PMID:20605918   PMID:20624904   PMID:21256972   PMID:21385842   PMID:21423176   PMID:21829547   PMID:22617836   PMID:23169788   PMID:23376485  
PMID:25117412  


Genomics

Comparative Map Data
Yes1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr89120,646,657 - 120,753,880 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl9120,646,838 - 120,746,441 (+)EnsemblGRCr8
mRatBN7.29113,200,256 - 113,275,942 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl9113,200,256 - 113,299,837 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx9121,684,273 - 121,760,004 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.09126,813,413 - 126,889,144 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.09125,159,312 - 125,235,046 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.09121,802,471 - 121,918,906 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl9121,802,673 - 121,902,678 (+)Ensemblrn6Rnor6.0
Rnor_5.09121,252,194 - 121,327,422 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.49112,516,831 - 112,564,072 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera9110,304,110 - 110,380,060 (+)NCBICelera
Cytogenetic Map9q38NCBI
YES1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3818721,588 - 812,753 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl18721,588 - 813,276 (-)Ensemblhg38GRCh38
GRCh3718721,588 - 812,243 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3618711,592 - 802,327 (-)NCBIBuild 36Build 36hg18NCBI36
Build 3418711,591 - 802,327NCBI
Celera18595,885 - 635,919 (-)NCBICelera
Cytogenetic Map18p11.32NCBI
HuRef18681,901 - 721,946 (-)NCBIHuRef
CHM1_118720,957 - 811,714 (-)NCBICHM1_1
T2T-CHM13v2.018875,925 - 969,846 (-)NCBIT2T-CHM13v2.0
Yes1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39532,768,502 - 32,844,410 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl532,768,515 - 32,844,401 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38532,611,171 - 32,687,066 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl532,611,171 - 32,687,057 (+)Ensemblmm10GRCm38
MGSCv37532,913,606 - 32,989,430 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36532,887,814 - 32,963,638 (+)NCBIMGSCv36mm8
Celera530,085,521 - 30,153,048 (+)NCBICelera
Cytogenetic Map5B1NCBI
cM Map517.33NCBI
Yes1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554029,226,295 - 9,256,044 (+)Ensembl
ChiLan1.0NW_0049554029,199,704 - 9,255,183 (+)NCBIChiLan1.0ChiLan1.0
YES1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21737,689,364 - 37,781,653 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11823,382,030 - 23,474,246 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01813,513,124 - 13,605,379 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11817,201,973 - 17,248,074 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1815,848,765 - 17,245,246 (+)EnsemblpanPan2panpan1.1
YES1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1767,532,790 - 67,598,285 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl767,532,790 - 67,598,285 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha766,986,484 - 67,051,985 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0767,598,792 - 67,664,338 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl767,598,792 - 67,664,338 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1767,275,521 - 67,341,129 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0767,287,110 - 67,352,610 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0767,589,051 - 67,654,785 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
YES1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl6105,505,479 - 105,600,687 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.16105,505,944 - 105,600,694 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
YES1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11860,086,011 - 60,168,973 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1860,088,525 - 60,120,114 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366605034,878,228 - 34,967,209 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Yes1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462477011,190,595 - 11,221,512 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462477011,190,103 - 11,275,823 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Yes1
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v14182,483,414 - 182,556,612 (-)NCBIRrattus_CSIRO_v1

miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:175
Count of miRNA genes:136
Interacting mature miRNAs:152
Transcripts:ENSRNOT00000056250, ENSRNOT00000056251
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2290450Scl57Serum cholesterol level QTL 574.15blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)944458256121768150Rat
1300134Bp185Blood pressure QTL 1853.73arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)968875497121768150Rat
2303178Bp334Blood pressure QTL 3343.70.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)986720043121768150Rat

Markers in Region
D9Got128  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.29113,266,747 - 113,267,037 (+)MAPPERmRatBN7.2
Rnor_6.09121,868,615 - 121,868,975NCBIRnor6.0
Rnor_5.09121,318,158 - 121,318,518UniSTSRnor5.0
RGSC_v3.49112,554,135 - 112,554,435RGDRGSC3.4
RGSC_v3.49112,554,148 - 112,554,435UniSTSRGSC3.4
Celera9110,370,870 - 110,371,155UniSTS
RGSC_v3.19112,763,627 - 112,763,915RGD
RH 3.4 Map9846.6RGD
RH 3.4 Map9846.6UniSTS
Cytogenetic Map9q38UniSTS
AI323763  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.29113,273,825 - 113,273,918 (+)MAPPERmRatBN7.2
Rnor_6.09121,875,764 - 121,875,856NCBIRnor6.0
Rnor_5.09121,325,307 - 121,325,399UniSTSRnor5.0
RGSC_v3.49112,561,956 - 112,562,048UniSTSRGSC3.4
Celera9110,377,944 - 110,378,036UniSTS
Cytogenetic Map9q38UniSTS
RH140391  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.29113,273,683 - 113,273,918 (+)MAPPERmRatBN7.2
Rnor_6.09121,875,622 - 121,875,856NCBIRnor6.0
Rnor_5.09121,325,165 - 121,325,399UniSTSRnor5.0
RGSC_v3.49112,561,814 - 112,562,048UniSTSRGSC3.4
Celera9110,377,802 - 110,378,036UniSTS
RH 3.4 Map9833.01UniSTS
Cytogenetic Map9q38UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 51 59 6 315 151 11 144 81 92 31 17 17

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001398584 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001398585 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_033298 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017596282 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017596283 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063266652 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063266653 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063266654 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063266655 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063266656 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063266657 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063266658 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063266659 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063266660 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_001839641 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_001839642 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_001839643 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_001839644 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_001839645 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_001839646 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_001839647 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_001839648 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_010054569 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_010054570 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB037472 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC079403 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH474043 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  D82931 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ215740 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000009 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000056250   ⟹   ENSRNOP00000053093
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl9121,831,716 - 121,873,578 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000056251   ⟹   ENSRNOP00000053094
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl9120,646,860 - 120,720,618 (+)Ensembl
mRatBN7.2 Ensembl9113,200,325 - 113,274,017 (+)Ensembl
Rnor_6.0 Ensembl9121,831,716 - 121,877,795 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000086534   ⟹   ENSRNOP00000072395
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl9120,646,838 - 120,722,532 (+)Ensembl
mRatBN7.2 Ensembl9113,200,256 - 113,299,837 (+)Ensembl
Rnor_6.0 Ensembl9121,802,673 - 121,902,678 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000141223   ⟹   ENSRNOP00000107592
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl9120,646,860 - 120,719,241 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000142471   ⟹   ENSRNOP00000099628
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl9120,646,860 - 120,746,441 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000173983   ⟹   ENSRNOP00000107102
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl9120,646,860 - 120,736,625 (+)Ensembl
RefSeq Acc Id: NM_001398584   ⟹   NP_001385513
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr89120,646,860 - 120,720,618 (+)NCBI
mRatBN7.29113,200,256 - 113,274,018 (+)NCBI
RefSeq Acc Id: NM_001398585   ⟹   NP_001385514
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr89120,646,860 - 120,720,618 (+)NCBI
mRatBN7.29113,200,256 - 113,274,018 (+)NCBI
RefSeq Acc Id: NM_033298   ⟹   NP_150640
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr89120,646,860 - 120,722,542 (+)NCBI
mRatBN7.29113,200,256 - 113,275,942 (+)NCBI
Rnor_6.09121,802,653 - 121,877,879 (+)NCBI
Rnor_5.09121,252,194 - 121,327,422 (+)NCBI
RGSC_v3.49112,516,831 - 112,564,072 (+)RGD
Celera9110,304,110 - 110,380,060 (+)RGD
Sequence:
RefSeq Acc Id: XM_063266652   ⟹   XP_063122722
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr89120,646,940 - 120,753,880 (+)NCBI
RefSeq Acc Id: XM_063266653   ⟹   XP_063122723
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr89120,647,291 - 120,753,880 (+)NCBI
RefSeq Acc Id: XM_063266654   ⟹   XP_063122724
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr89120,646,657 - 120,753,880 (+)NCBI
RefSeq Acc Id: XM_063266655   ⟹   XP_063122725
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr89120,646,676 - 120,753,880 (+)NCBI
RefSeq Acc Id: XM_063266656   ⟹   XP_063122726
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr89120,647,503 - 120,753,880 (+)NCBI
RefSeq Acc Id: XM_063266657   ⟹   XP_063122727
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr89120,646,657 - 120,720,618 (+)NCBI
RefSeq Acc Id: XM_063266658   ⟹   XP_063122728
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr89120,647,291 - 120,720,618 (+)NCBI
RefSeq Acc Id: XM_063266659   ⟹   XP_063122729
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr89120,646,940 - 120,753,880 (+)NCBI
RefSeq Acc Id: XM_063266660   ⟹   XP_063122730
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr89120,646,940 - 120,753,880 (+)NCBI
RefSeq Acc Id: XR_010054569
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr89120,646,940 - 120,753,880 (+)NCBI
RefSeq Acc Id: XR_010054570
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr89120,646,940 - 120,745,791 (+)NCBI
RefSeq Acc Id: NP_150640   ⟸   NM_033298
- Peptide Label: isoform 2
- UniProtKB: F1LM93 (UniProtKB/Swiss-Prot),   Q6AXQ3 (UniProtKB/TrEMBL),   F1LM92 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000053094   ⟸   ENSRNOT00000056251
Ensembl Acc Id: ENSRNOP00000053093   ⟸   ENSRNOT00000056250
Ensembl Acc Id: ENSRNOP00000072395   ⟸   ENSRNOT00000086534
RefSeq Acc Id: NP_001385514   ⟸   NM_001398585
- Peptide Label: isoform 1
- UniProtKB: F1LM93 (UniProtKB/Swiss-Prot),   Q99PW1 (UniProtKB/TrEMBL),   A6KFB6 (UniProtKB/TrEMBL),   A0A8J8XNH3 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001385513   ⟸   NM_001398584
- Peptide Label: isoform 1
- UniProtKB: F1LM93 (UniProtKB/Swiss-Prot),   Q99PW1 (UniProtKB/TrEMBL),   A6KFB6 (UniProtKB/TrEMBL),   A0A8J8XNH3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063122724   ⟸   XM_063266654
- Peptide Label: isoform X1
RefSeq Acc Id: XP_063122727   ⟸   XM_063266657
- Peptide Label: isoform X2
- UniProtKB: F1LM93 (UniProtKB/Swiss-Prot),   A0A8J8XNH3 (UniProtKB/TrEMBL),   A6KFB6 (UniProtKB/TrEMBL),   Q99PW1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063122725   ⟸   XM_063266655
- Peptide Label: isoform X1
RefSeq Acc Id: XP_063122722   ⟸   XM_063266652
- Peptide Label: isoform X1
RefSeq Acc Id: XP_063122729   ⟸   XM_063266659
- Peptide Label: isoform X3
RefSeq Acc Id: XP_063122730   ⟸   XM_063266660
- Peptide Label: isoform X4
RefSeq Acc Id: XP_063122723   ⟸   XM_063266653
- Peptide Label: isoform X1
RefSeq Acc Id: XP_063122728   ⟸   XM_063266658
- Peptide Label: isoform X2
- UniProtKB: F1LM93 (UniProtKB/Swiss-Prot),   A0A8J8XNH3 (UniProtKB/TrEMBL),   A6KFB6 (UniProtKB/TrEMBL),   Q99PW1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063122726   ⟸   XM_063266656
- Peptide Label: isoform X1
Ensembl Acc Id: ENSRNOP00000107102   ⟸   ENSRNOT00000173983
Ensembl Acc Id: ENSRNOP00000099628   ⟸   ENSRNOT00000142471
Ensembl Acc Id: ENSRNOP00000107592   ⟸   ENSRNOT00000141223
Protein Domains
Protein kinase   SH2   SH3

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-F1LM93-F1-model_v2 AlphaFold F1LM93 1-541 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13696923
Promoter ID:EPDNEW_R7442
Type:initiation region
Name:Yes1_1
Description:YES proto-oncogene 1, Src family tyrosine kinase
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.09121,802,712 - 121,802,772EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3977 AgrOrtholog
BioCyc Gene G2FUF-26306 BioCyc
Ensembl Genes ENSRNOG00000037227 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000056251 ENTREZGENE
  ENSRNOT00000086534 ENTREZGENE
Gene3D-CATH 3.30.505.10 UniProtKB/Swiss-Prot
  Phosphorylase Kinase, domain 1 UniProtKB/Swiss-Prot
  SH3 Domains UniProtKB/Swiss-Prot
  Transferase(Phosphotransferase) domain 1 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7112783 IMAGE-MGC_LOAD
InterPro Kinase-like_dom_sf UniProtKB/Swiss-Prot
  Non-receptor_tyrosine_kinases UniProtKB/Swiss-Prot
  Prot_kinase_dom UniProtKB/Swiss-Prot
  Protein_kinase_ATP_BS UniProtKB/Swiss-Prot
  Ser-Thr/Tyr_kinase_cat_dom UniProtKB/Swiss-Prot
  SH2 UniProtKB/Swiss-Prot
  SH2_dom_sf UniProtKB/Swiss-Prot
  SH3-like_dom_sf UniProtKB/Swiss-Prot
  SH3_domain UniProtKB/Swiss-Prot
  Tyr_kinase_AS UniProtKB/Swiss-Prot
  Tyr_kinase_cat_dom UniProtKB/Swiss-Prot
  Yes_SH3 UniProtKB/Swiss-Prot
MGC_CLONE MGC:94936 IMAGE-MGC_LOAD
NCBI Gene 24884 ENTREZGENE
PANTHER TYROSINE-PROTEIN KINASE UniProtKB/Swiss-Prot
Pfam Pkinase_Tyr UniProtKB/Swiss-Prot
  SH2 UniProtKB/Swiss-Prot
  SH3_1 UniProtKB/Swiss-Prot
PhenoGen Yes1 PhenoGen
PRINTS SH2DOMAIN UniProtKB/Swiss-Prot
  SH3DOMAIN UniProtKB/Swiss-Prot
  TYRKINASE UniProtKB/Swiss-Prot
PROSITE PROTEIN_KINASE_ATP UniProtKB/Swiss-Prot
  PROTEIN_KINASE_DOM UniProtKB/Swiss-Prot
  PROTEIN_KINASE_TYR UniProtKB/Swiss-Prot
  SH2 UniProtKB/Swiss-Prot
  SH3 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000037227 RatGTEx
SMART SH2 UniProtKB/Swiss-Prot
  SH3 UniProtKB/Swiss-Prot
  TyrKc UniProtKB/Swiss-Prot
Superfamily-SCOP SSF50044 UniProtKB/Swiss-Prot
  SSF55550 UniProtKB/Swiss-Prot
  SSF56112 UniProtKB/Swiss-Prot
UniProt A0A8J8XNH3 ENTREZGENE, UniProtKB/TrEMBL
  A0ABK0L9P4_RAT UniProtKB/TrEMBL
  A0ABK0LHF5_RAT UniProtKB/TrEMBL
  A0ABK0LYD3_RAT UniProtKB/TrEMBL
  A6KFB6 ENTREZGENE, UniProtKB/TrEMBL
  F1LM92 ENTREZGENE
  F1LM93 ENTREZGENE
  Q6AXQ3 ENTREZGENE, UniProtKB/TrEMBL
  Q99PW1 ENTREZGENE
  YES_RAT UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-03-16 Yes1  YES proto-oncogene 1, Src family tyrosine kinase  Yes1  Yamaguchi sarcoma viral (v-yes) oncogene homolog 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-02-23 Yes1  Yamaguchi sarcoma viral (v-yes) oncogene homolog 1  Yes_predicted  Yamaguchi sarcoma viral (v-yes) oncogene homolog (predicted)  Data merged from RGD:1310443 737654 APPROVED
2005-01-12 Yes_predicted  Yamaguchi sarcoma viral (v-yes) oncogene homolog (predicted)      Symbol and Name status set to provisional 70820 PROVISIONAL
2003-04-09 Yes1  Yamaguchi sarcoma viral (v-yes) oncogene homolog 1    Yamagichi sarcoma viral (v-yes-1) oncogene homolog 1  Name updated 629478 APPROVED
2002-06-10 Yes1  Yamagichi sarcoma viral (v-yes-1) oncogene homolog 1      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_cellular_localization localized to the plasma membrane fraction 634514