Ugt2b37 (UDP-glucuronosyltransferase 2 family, member 37) - Rat Genome Database

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Gene: Ugt2b37 (UDP-glucuronosyltransferase 2 family, member 37) Rattus norvegicus
Analyze
No known orthologs.
Symbol: Ugt2b37
Name: UDP-glucuronosyltransferase 2 family, member 37
RGD ID: 3937
Description: Enables glucuronosyltransferase activity. Predicted to be located in endoplasmic reticulum membrane. Orthologous to several human genes including UGT2B10 (UDP glucuronosyltransferase family 2 member B10); UGT2B11 (UDP glucuronosyltransferase family 2 member B11); and UGT2B15 (UDP glucuronosyltransferase family 2 member B15); PARTICIPATES IN ascorbate and aldarate metabolic pathway; O-linked glycan biosynthetic pathway; pentose and glucuronate interconversion pathway; INTERACTS WITH (+)-schisandrin B; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 17-beta-hydroxysteroid specific; 17-beta-hydroxysteroid-specific UDPGT; UDP-glucuronosyltransferase 2 family, member 5; UDP-glucuronosyltransferase 2B37; UDP-glucuronosyltransferase 2B5; UDP-glucuronosyltransferase R-21; UDPGT 2B37; UDPGT 2B5; UDPGTr-21; UDPGTr-5; Ugt2b5
RGD Orthologs
Alliance Orthologs
More Info homologs ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81421,172,136 - 21,188,768 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1421,172,133 - 21,190,661 (+)EnsemblGRCr8
mRatBN7.21420,817,285 - 20,833,917 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1420,817,285 - 20,833,917 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1421,155,092 - 21,171,710 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01422,474,023 - 22,490,641 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01421,005,119 - 21,021,737 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01422,495,084 - 22,534,865 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1422,375,955 - 22,534,720 (+)Ensemblrn6Rnor6.0
Rnor_5.01422,418,687 - 22,435,535 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41422,404,705 - 22,421,315 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1420,325,559 - 20,354,202 (+)NCBICelera
RGSC_v3.11422,404,704 - 22,421,315 (+)NCBI
Cytogenetic Map14p21NCBI
JBrowse:




Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. The cDNA sequence and expression of a variant 17 beta-hydroxysteroid UDP-glucuronosyltransferase. Mackenzie PI J Biol Chem 1990 May 25;265(15):8699-703.
3. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
4. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
5. GOA pipeline RGD automated data pipeline
6. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
7. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
Additional References at PubMed
PMID:12477932  


Genomics

Variants

.
Variants in Ugt2b37
76 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:17
Count of miRNA genes:16
Interacting mature miRNAs:17
Transcripts:ENSRNOT00000047655
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300114Srn2Serum renin concentration QTL 23.27blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)14395787821572472Rat
631528Scl11Serum cholesterol level QTL 114.9blood cholesterol amount (VT:0000180)blood total cholesterol level (CMO:0000051)141787564536079022Rat
7411573Bw139Body weight QTL 1394.70.001body mass (VT:0001259)body weight gain (CMO:0000420)14140068101Rat
9589814Gluco67Glucose level QTL 674.540.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)14140068101Rat
731183Pia20Pristane induced arthritis QTL 203.55joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)14939329839411170Rat
631212Bw5Body weight QTL55.43retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)141133490630674469Rat
2302277Gluco38Glucose level QTL 385.8blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)141133471628389666Rat
1331740Bw26Body weight QTL 263.028body mass (VT:0001259)body weight (CMO:0000012)14395787831121464Rat
1358296Ael3Aortic elastin QTL 33.70.00051aorta elastin amount (VT:0003905)aortic elastin14862139853621398Rat
61420Pia6Pristane induced arthritis QTL 64.9joint integrity trait (VT:0010548)arthritic paw count (CMO:0001460)141891545442433608Rat
70195Mcs8Mammary carcinoma susceptibility QTL 84.28mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)14395787824886169Rat
631839Niddm37Non-insulin dependent diabetes mellitus QTL 373.37blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1411334716100078267Rat
2313397Coatc1Coat color QTL1coat/hair pigmentation trait (VT:0010463)coat/hair color measurement (CMO:0001808)141889519263895192Rat
631262Tcas4Tongue tumor susceptibility QTL 47.29tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)141790672654251504Rat
634352Apr6Acute phase response QTL 63.7blood interleukin-6 amount (VT:0008595)plasma interleukin-6 level (CMO:0001927)14141415516Rat
70204Niddm20Non-insulin dependent diabetes mellitus QTL 205.10.000008blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)14131893212Rat
2302045Pia39Pristane induced arthritis QTL 394.90.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G2a level (CMO:0002116)14862139853621398Rat
1300140Srn3Serum renin concentration QTL 33.19blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)141513759431238250Rat

Markers in Region
AI118071  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21420,833,484 - 20,833,616 (+)MAPPERmRatBN7.2
Rnor_6.01422,534,189 - 22,534,320NCBIRnor6.0
Rnor_5.01422,435,117 - 22,435,248UniSTSRnor5.0
RGSC_v3.41422,420,905 - 22,421,036UniSTSRGSC3.4
Cytogenetic Map14p21UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
6 5 27 33 30 18 4 18 6 51 18 16 9 18 12

Sequence


Ensembl Acc Id: ENSRNOT00000047655   ⟹   ENSRNOP00000045002
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1420,817,285 - 20,833,917 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000130103   ⟹   ENSRNOP00000109960
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1421,172,133 - 21,190,661 (+)Ensembl
RefSeq Acc Id: NM_001007264   ⟹   NP_001007265
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81421,172,136 - 21,188,768 (+)NCBI
mRatBN7.21420,817,285 - 20,833,917 (+)NCBI
Rnor_6.01422,517,759 - 22,534,621 (+)NCBI
Rnor_5.01422,418,687 - 22,435,535 (+)NCBI
RGSC_v3.41422,404,705 - 22,421,315 (+)RGD
Celera1420,325,559 - 20,354,202 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001007265 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA03216 (Get FASTA)   NCBI Sequence Viewer  
  AAA03217 (Get FASTA)   NCBI Sequence Viewer  
  AAA03218 (Get FASTA)   NCBI Sequence Viewer  
  AAA03219 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000109960
GenBank Protein P19488 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_001007265   ⟸   NM_001007264
- Peptide Label: precursor
- UniProtKB: P19489 (UniProtKB/Swiss-Prot),   P19488 (UniProtKB/Swiss-Prot),   F1M7N8 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000045002   ⟸   ENSRNOT00000047655
Ensembl Acc Id: ENSRNOP00000109960   ⟸   ENSRNOT00000130103

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P19488-F1-model_v2 AlphaFold P19488 1-530 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13699255
Promoter ID:EPDNEW_R9779
Type:initiation region
Name:Ugt2b_3
Description:UDP glycosyltransferase 2 family, polypeptide B
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R9778  EPDNEW_R9777  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01422,517,753 - 22,517,813EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3937 AgrOrtholog
BioCyc Gene G2FUF-16101 BioCyc
Ensembl Genes ENSRNOG00000046540 Ensembl
  ENSRNOG00000081572 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000130103 ENTREZGENE
Gene3D-CATH Glycogen Phosphorylase B UniProtKB/Swiss-Prot
InterPro UDP-glycosyltransferase UniProtKB/Swiss-Prot
  UDP_glucos_trans UniProtKB/Swiss-Prot
  UDP_glycos_trans_CS UniProtKB/Swiss-Prot
NCBI Gene 29623 ENTREZGENE
PANTHER EG:EG0003.4 PROTEIN-RELATED UniProtKB/Swiss-Prot
  UDP GLUCURONOSYLTRANSFERASE 2 FAMILY, POLYPEPTIDE B38-RELATED UniProtKB/Swiss-Prot
Pfam UDPGT UniProtKB/Swiss-Prot
PhenoGen Ugt2b37 PhenoGen
PROSITE UDPGT UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000046540 RatGTEx
  ENSRNOG00000081572 RatGTEx
Superfamily-SCOP UDP-Glycosyltransferase/glycogen phosphorylase UniProtKB/Swiss-Prot
TIGR TC232113
UniProt A0ABK0LGK3_RAT UniProtKB/TrEMBL
  F1M7N8 ENTREZGENE, UniProtKB/TrEMBL
  P19488 ENTREZGENE
  P19489 ENTREZGENE
  UDB37_RAT UniProtKB/Swiss-Prot
UniProt Secondary P19489 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-03-31 Ugt2b37  UDP-glucuronosyltransferase 2 family, member 37  Ugt2b5  UDP-glucuronosyltransferase 2 family, member 5   Symbol and Name updated to reflect Human and Mouse nomenclature 1299863 APPROVED
2002-06-10 Ugt2b5  UDP-glucuronosyltransferase 2 family, member 5       Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_domains contains a signal peptide and a transmembrane-anchoring domain at the carboxyl terminus 70049