Ugt2b (UDP glycosyltransferase 2 family, polypeptide B) - Rat Genome Database

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Gene: Ugt2b (UDP glycosyltransferase 2 family, polypeptide B) Rattus norvegicus
Analyze
No known orthologs.
Symbol: Ugt2b
Name: UDP glycosyltransferase 2 family, polypeptide B
RGD ID: 3936
Description: Enables glucuronosyltransferase activity. Predicted to be located in endoplasmic reticulum membrane. Orthologous to several human genes including UGT2B10 (UDP glucuronosyltransferase family 2 member B10); UGT2B11 (UDP glucuronosyltransferase family 2 member B11); and UGT2B15 (UDP glucuronosyltransferase family 2 member B15); PARTICIPATES IN ascorbate and aldarate metabolic pathway; O-linked glycan biosynthetic pathway; pentose and glucuronate interconversion pathway; INTERACTS WITH 1-naphthyl isothiocyanate; 17alpha-ethynylestradiol; 2,3,4,7,8-Pentachlorodibenzofuran.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 3-hydroxyandrogen specific; 3-hydroxyandrogen-specific UDPGT; Androsterone UDP-glucuronosyltransferase; LOC688226; RLUG23; UDP glucuronosyltransferase; UDP-glucuronosyltransferase 2B2; UDPGT 2B2; UDPGTr-4; Ugt2b2
RGD Orthologs
Alliance Orthologs
More Info homologs ...
Related Pseudogenes: Ugt2b-ps1  
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81420,985,449 - 21,006,267 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1420,985,108 - 21,020,850 (+)EnsemblGRCr8
mRatBN7.21420,630,572 - 20,665,062 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1420,630,250 - 20,651,776 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1420,820,758 - 20,841,575 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01422,139,677 - 22,160,494 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
Rnor_6.0 Ensembl1422,375,955 - 22,534,720 (+)Ensemblrn6Rnor6.0
Rnor_5.01422,323,542 - 22,344,064 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41422,154,370 - 22,178,222 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
RGSC_v3.11422,066,518 - 22,177,852 (+)NCBI
Cytogenetic Map14p21NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. The full length coding sequence of rat liver androsterone UDP-glucuronyltransferase cDNA and comparison with other members of this gene family. Jackson MR and Burchell B, Nucleic Acids Res 1986 Jan 24;14(2):779-95.
3. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
4. Rat liver UDP-glucuronosyltransferase. cDNA sequence and expression of a form glucuronidating 3-hydroxyandrogens. Mackenzie PI J Biol Chem 1986 Oct 25;261(30):14112-7.
5. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
6. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
7. GOA pipeline RGD automated data pipeline
8. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:1909872   PMID:7492328   PMID:12477932   PMID:17435758   PMID:23230277  


Genomics

Variants

.
Variants in Ugt2b
289 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:53
Count of miRNA genes:46
Interacting mature miRNAs:48
Transcripts:ENSRNOT00000052369
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300114Srn2Serum renin concentration QTL 23.27blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)14395787821572472Rat
631528Scl11Serum cholesterol level QTL 114.9blood cholesterol amount (VT:0000180)blood total cholesterol level (CMO:0000051)141787564536079022Rat
7411573Bw139Body weight QTL 1394.70.001body mass (VT:0001259)body weight gain (CMO:0000420)14140068101Rat
9589814Gluco67Glucose level QTL 674.540.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)14140068101Rat
731183Pia20Pristane induced arthritis QTL 203.55joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)14939329839411170Rat
631212Bw5Body weight QTL55.43retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)141133490630674469Rat
2302277Gluco38Glucose level QTL 385.8blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)141133471628389666Rat
1331740Bw26Body weight QTL 263.028body mass (VT:0001259)body weight (CMO:0000012)14395787831121464Rat
1358296Ael3Aortic elastin QTL 33.70.00051aorta elastin amount (VT:0003905)aortic elastin14862139853621398Rat
61420Pia6Pristane induced arthritis QTL 64.9joint integrity trait (VT:0010548)arthritic paw count (CMO:0001460)141891545442433608Rat
70195Mcs8Mammary carcinoma susceptibility QTL 84.28mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)14395787824886169Rat
631839Niddm37Non-insulin dependent diabetes mellitus QTL 373.37blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1411334716100078267Rat
2313397Coatc1Coat color QTL1coat/hair pigmentation trait (VT:0010463)coat/hair color measurement (CMO:0001808)141889519263895192Rat
631262Tcas4Tongue tumor susceptibility QTL 47.29tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)141790672654251504Rat
634352Apr6Acute phase response QTL 63.7blood interleukin-6 amount (VT:0008595)plasma interleukin-6 level (CMO:0001927)14141415516Rat
70204Niddm20Non-insulin dependent diabetes mellitus QTL 205.10.000008blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)14131893212Rat
2302045Pia39Pristane induced arthritis QTL 394.90.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G2a level (CMO:0002116)14862139853621398Rat
1300140Srn3Serum renin concentration QTL 33.19blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)141513759431238250Rat

Markers in Region
RH127922  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21420,651,730 - 20,651,948 (+)MAPPERmRatBN7.2
Rnor_6.01422,438,390 - 22,438,607NCBIRnor6.0
Rnor_6.01422,157,582 - 22,157,799NCBIRnor6.0
Rnor_5.01422,071,655 - 22,071,872UniSTSRnor5.0
Rnor_5.01422,344,386 - 22,344,603UniSTSRnor5.0
RGSC_v3.41422,179,529 - 22,179,746UniSTSRGSC3.4
RGSC_v3.41422,178,177 - 22,179,746UniSTSRGSC3.4
Cytogenetic Map14p22-p21.2UniSTS


Expression

RNA-SEQ Expression

hemolymphoid system
mesenchyme
mesoderm
renal system
1 17 1 16

Sequence


Ensembl Acc Id: ENSRNOT00000052369   ⟹   ENSRNOP00000043239
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1420,985,108 - 21,006,634 (+)Ensembl
mRatBN7.2 Ensembl1420,630,250 - 20,651,776 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000145904   ⟹   ENSRNOP00000112858
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1420,985,451 - 21,020,850 (+)Ensembl
RefSeq Acc Id: NM_031533   ⟹   NP_113721
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81420,985,449 - 21,006,267 (+)NCBI
mRatBN7.21420,630,591 - 20,651,409 (+)NCBI
Rnor_5.01422,323,542 - 22,344,064 (+)NCBI
RGSC_v3.41422,154,370 - 22,178,222 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_113721 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH89792 (Get FASTA)   NCBI Sequence Viewer  
  CAA27198 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000043239
GenBank Protein P08541 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_113721   ⟸   NM_031533
- Peptide Label: precursor
- UniProtKB: Q5EBC8 (UniProtKB/TrEMBL),   A1XF83 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000043239   ⟸   ENSRNOT00000052369
Ensembl Acc Id: ENSRNOP00000112858   ⟸   ENSRNOT00000145904

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P08541-F1-model_v2 AlphaFold P08541 1-530 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3936 AgrOrtholog
BioCyc Gene G2FUF-16112 BioCyc
BioCyc Pathway PWY-5874 [heme degradation I] BioCyc
  PWY-6261 [thyroid hormone metabolism II (via conjugation and/or degradation)] BioCyc
  PWY-6313 [serotonin degradation] BioCyc
  PWY-6398 [melatonin degradation I] BioCyc
BioCyc Pathway Image PWY-5874 BioCyc
  PWY-6261 BioCyc
  PWY-6313 BioCyc
  PWY-6398 BioCyc
Ensembl Genes ENSRNOG00000046540 Ensembl
  ENSRNOG00000069670 Ensembl
  ENSRNOG00000083891 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000052369 ENTREZGENE
Gene3D-CATH Glycogen Phosphorylase B UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7370057 IMAGE-MGC_LOAD
InterPro UDP-glycosyltransferase UniProtKB/Swiss-Prot
  UDP_glucos_trans UniProtKB/Swiss-Prot
  UDP_glycos_trans_CS UniProtKB/Swiss-Prot
MGC_CLONE MGC:108656 IMAGE-MGC_LOAD
NCBI Gene 24862 ENTREZGENE
PANTHER EG:EG0003.4 PROTEIN-RELATED UniProtKB/Swiss-Prot
  UDP GLUCURONOSYLTRANSFERASE 2 FAMILY, POLYPEPTIDE B38-RELATED UniProtKB/Swiss-Prot
Pfam UDPGT UniProtKB/Swiss-Prot
PhenoGen Ugt2b PhenoGen
PROSITE UDPGT UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000046540 RatGTEx
  ENSRNOG00000069670 RatGTEx
  ENSRNOG00000083891 RatGTEx
Superfamily-SCOP UDP-Glycosyltransferase/glycogen phosphorylase UniProtKB/Swiss-Prot
UniProt A0ABK0L4Q8_RAT UniProtKB/TrEMBL
  A0ABK0M0V7_RAT UniProtKB/TrEMBL
  A0ABK0M3P2_RAT UniProtKB/TrEMBL
  A1XF83 ENTREZGENE, UniProtKB/TrEMBL
  P08541 ENTREZGENE
  Q5EBC8 ENTREZGENE, UniProtKB/TrEMBL
  UD2B2_RAT UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-03-29 Ugt2b  UDP glycosyltransferase 2 family, polypeptide B  LOC688226  similar to UDP-glucuronosyltransferase 2B2 precursor (UDPGT) (3-hydroxyandrogen specific) (UDPGTr-4) (RLUG23)  Data merged from RGD:1591199 737654 PROVISIONAL
2006-11-20 LOC688226  similar to UDP-glucuronosyltransferase 2B2 precursor (UDPGT) (3-hydroxyandrogen specific) (UDPGTr-4) (RLUG23)      Symbol and Name status set to provisional 70820 PROVISIONAL
2003-04-09 Ugt2b  UDP glycosyltransferase 2 family, polypeptide B  Ugt2b2  Androsterone UDP-glucuronosyltransferase  Symbol and Name updated 629477 APPROVED
2002-06-10 Ugt2b2  Androsterone UDP-glucuronosyltransferase      Symbol and Name status set to approved 70586 APPROVED