Scgb1a1 (secretoglobin family 1A member 1) - Rat Genome Database

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Gene: Scgb1a1 (secretoglobin family 1A member 1) Rattus norvegicus
Analyze
Symbol: Scgb1a1
Name: secretoglobin family 1A member 1
RGD ID: 3934
Description: Enables polychlorinated biphenyl binding activity. Involved in several processes, including response to lipopolysaccharide; response to ozone; and response to silicon dioxide. Located in extracellular space; nuclear envelope; and secretory granule. Biomarker of acute kidney failure; asthma; otitis media; and pulmonary fibrosis. Human ortholog(s) of this gene implicated in IgA glomerulonephritis; asthma; and glomerulonephritis. Orthologous to human SCGB1A1 (secretoglobin family 1A member 1); PARTICIPATES IN forkhead class A signaling pathway; INTERACTS WITH 17alpha-ethynylestradiol; 17beta-estradiol; 17beta-estradiol 3-benzoate.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: CC10; CC16; CCPBP; CCSP; clara cell phospholipid-binding protein; clara cells 10 kDa secretory protein; club cell protein 16; club secretory protein-16; PCB-binding protein; PCBB; secretoglobin, family 1A, member 1; secretoglobin, family 1A, member 1 (uteroglobin); Ugb; uteroglobin; Uteroglobin (Clara cell secretory protein); Uteroglobin (club cell secretory protein)
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81215,406,138 - 215,409,686 (-)NCBIGRCr8
mRatBN7.21205,977,060 - 205,980,610 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1205,977,060 - 205,980,610 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1214,394,838 - 214,398,402 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01221,420,410 - 221,423,956 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01214,109,801 - 214,113,347 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01225,279,698 - 225,283,246 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1225,279,676 - 225,283,326 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01232,216,740 - 232,220,289 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41211,758,103 - 211,761,651 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11211,916,532 - 211,920,081 (-)NCBI
Celera1203,487,454 - 203,490,852 (-)NCBICelera
Cytogenetic Map1q43NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP)
17beta-estradiol 3-benzoate  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
4-amino-2,6-dinitrotoluene  (EXP)
6-propyl-2-thiouracil  (EXP)
aflatoxin B1  (ISO)
aluminium atom  (EXP,ISO)
aluminium(0)  (EXP,ISO)
amiodarone  (EXP)
ammonium chloride  (EXP)
arsane  (ISO)
arsenic atom  (ISO)
atrazine  (ISO)
benzo[a]pyrene  (ISO)
Benzo[k]fluoranthene  (ISO)
bis(2-chloroethyl) sulfide  (EXP,ISO)
bleomycin A2  (EXP)
butane-2,3-dione  (EXP)
C60 fullerene  (EXP)
cadmium atom  (EXP)
Calcium arsenate  (ISO)
calcium atom  (ISO)
calcium(0)  (ISO)
carbon nanotube  (ISO)
cerium trichloride  (ISO)
CGP 52608  (ISO)
chlorpyrifos  (ISO)
ciguatoxin CTX1B  (ISO)
clofibrate  (ISO)
copper atom  (EXP)
copper(0)  (EXP)
crocidolite asbestos  (ISO)
Cuprizon  (EXP)
decabromodiphenyl ether  (EXP)
dextran sulfate  (ISO)
dioxygen  (ISO)
doxorubicin  (EXP,ISO)
fenvalerate  (EXP)
fipronil  (EXP)
furan  (EXP)
hydrogen chloride  (EXP)
lidocaine  (EXP)
naphthalene  (ISO)
nickel subsulfide  (EXP)
nickel sulfate  (ISO)
nitric oxide  (ISO)
nitrofen  (EXP,ISO)
nitroglycerin  (EXP)
ozone  (EXP,ISO)
paracetamol  (ISO)
paraquat  (ISO)
pentane-2,3-dione  (ISO)
perfluorohexanesulfonic acid  (ISO)
pirinixic acid  (ISO)
quercetin  (EXP)
silicon carbide  (EXP)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
styrene  (ISO)
styrene oxide  (ISO)
tamoxifen  (ISO)
testosterone  (EXP)
titanium dioxide  (ISO)
triptonide  (ISO)
vinclozolin  (EXP)
vinyl carbamate  (ISO)
zinc atom  (EXP)
zinc(0)  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Gene profiling reveals decreased expression of uteroglobin and other anti-inflammatory genes in nasal fluid cells from patients with intermittent allergic rhinitis. Benson M, etal., Clin Exp Allergy. 2005 Apr;35(4):473-8.
2. Changes in Clara cell 10 kDa protein (CC10)-positive cell distribution in acute lung injury following repeated lipopolysaccharide challenge in the rat. Bolton SJ, etal., Toxicol Pathol. 2008;36(3):440-8. Epub 2008 Apr 17.
3. Secretory product expression during Clara cell differentiation in the rabbit and rat. Cardoso WV, etal., Am J Physiol. 1993 Jun;264(6 Pt 1):L543-52.
4. Modulation of aquaporin-2/vasopressin2 receptor kidney expression and tubular injury after endotoxin (lipopolysaccharide) challenge. Chagnon F, etal., Crit Care Med. 2008 Nov;36(11):3054-61.
5. Role of distinct phospholipases A2 and their modulators in meconium aspiration syndrome in human neonates. De Luca D, etal., Intensive Care Med. 2011 Jul;37(7):1158-65. Epub 2011 May 13.
6. Regulation of Clara cell 10 kD protein secretion by pilocarpine: quantitative comparison of nonciliated cells in rat bronchi and bronchioles based on laser scanning confocal microscopy. Dodge DE, etal., Am J Respir Cell Mol Biol. 1994 Mar;10(3):259-70.
7. Response of bronchiolar Clara cells induced by a domestic insecticide. Analysis of CC10 kDa protein content. Elia J, etal., Histochem Cell Biol. 2000 Feb;113(2):125-33.
8. Regulation of uteroglobin/Clara cell protein expression after acute lung exposure to an organophosphoreted insecticide. Elia J, etal., Histochem Cell Biol. 2003 Jul;120(1):33-9. Epub 2003 Jul 1.
9. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
10. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
11. Solution structure of a mammalian PCB-binding protein in complex with a PCB. Hard T, etal., Nat Struct Biol. 1995 Nov;2(11):983-9.
12. Use of serum clara cell 16-kDa (CC16) levels as a potential indicator of active pulmonary fibrosis in systemic sclerosis. Hasegawa M, etal., J Rheumatol. 2011 May;38(5):877-84. Epub 2011 Jan 15.
13. Inflammatory and epithelial responses in mouse strains that differ in sensitivity to hyperoxic injury. Johnston CJ, etal., Exp Lung Res. 1998 Mar-Apr;24(2):189-202.
14. Eosinophilic inclusions in rat Clara cells and the effect of an inhaled corticosteroid. Kambara T, etal., Toxicol Pathol. 2009;37(3):315-23.
15. IL-13-induced Clara cell secretory protein expression in airway epithelium: role of EGFR signaling pathway. Kim S, etal., Am J Physiol Lung Cell Mol Physiol 2002 Jul;283(1):L67-75.
16. Expression of Clara cell secretory protein in experimental otitis media in the rat. Kim SJ and Jung HH, Acta Otolaryngol. 2005 Jan;125(1):43-7.
17. The CC16 A38G polymorphism is associated with the development of asthma in children with allergic rhinitis. Ku MS, etal., Clin Exp Allergy. 2011 Jun;41(6):794-800. doi: 10.1111/j.1365-2222.2010.03679.x. Epub 2011 Jan 24.
18. Adenoviral-mediated uteroglobin gene transfer inhibits neointimal hyperplasia after balloon injury in the rat carotid artery. Larson RA, etal., J Vasc Surg. 2000 Dec;32(6):1111-7.
19. [Expression of Clara cell secretory protein in airways of rat asthma remodel]. Luo FM, etal., Zhonghua Nei Ke Za Zhi. 2003 Jul;42(7):466-9.
20. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
21. Expression of clara cell secretory protein in the lungs of rats exposed to crystalline silica in vivo. Morimoto Y, etal., J Occup Health. 2005 Nov;47(6):504-9.
22. Role of uteroglobin G38A polymorphism in the progression of IgA nephropathy in Japanese patients. Narita I, etal., Kidney Int. 2002 May;61(5):1853-8.
23. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
24. Decreased serum and bronchoalveolar lavage levels of Clara cell secretory protein (CC16) is associated with bronchiolitis obliterans syndrome and airway neutrophilia in lung transplant recipients. Nord M, etal., Transplantation. 2002 Apr 27;73(8):1264-9.
25. Cloning, structure, and expression of a rat binding protein for polychlorinated biphenyls. Homology to the hormonally regulated progesterone-binding protein uteroglobin. Nordlund-Moller L, etal., J Biol Chem 1990 Jul 25;265(21):12690-3.
26. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
27. Antagonistic effects of dexamethasone and retinoic acid on rat lung morphogenesis. Oshika E, etal., Pediatr Res. 1998 Mar;43(3):315-24.
28. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
29. Elevation of susceptibility to ozone-induced acute tracheobronchial injury in transgenic mice deficient in Clara cell secretory protein. Plopper CG, etal., Toxicol Appl Pharmacol. 2006 May 15;213(1):74-85. Epub 2005 Oct 14.
30. Clara cell secretory protein oxidation and expression in premature infants who develop bronchopulmonary dysplasia. Ramsay PL, etal., Am J Respir Crit Care Med. 2001 Jul 1;164(1):155-61.
31. GOA pipeline RGD automated data pipeline
32. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
33. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
34. Effect of chronic daily ozone exposure on Clara cell secretory protein mRNA expression in the adult rat lung. Royce FH and Plopper CG, Exp Lung Res. 1997 Jan-Feb;23(1):51-64.
35. Polydatin up-regulates Clara cell secretory protein to suppress phospholipase A2 of lung induced by LPS in vivo and in vitro. Shiyu S, etal., BMC Cell Biol. 2011 Jul 25;12(1):31.
36. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
37. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
38. CCSP modulates airway dysfunction and host responses in an Ova-challenged mouse model. Wang SZ, etal., Am J Physiol Lung Cell Mol Physiol. 2001 Nov;281(5):L1303-11.
39. Clara cell secretory protein modulates lung inflammatory and immune responses to respiratory syncytial virus infection. Wang SZ, etal., J Immunol. 2003 Jul 15;171(2):1051-60.
40. Expression of uteroglobin in a murine model of allergic rhinitis. Won TB, etal., Acta Otolaryngol Suppl. 2007 Oct;(558):83-9.
41. The protective role of uteroglobin through the modulation of tissue transglutaminase in the experimental crescentic glomerulonephritis. Yang SH, etal., Nephrol Dial Transplant. 2008 Nov;23(11):3437-45. Epub 2008 Jun 16.
42. KGF regulates pulmonary epithelial proliferation and surfactant protein gene expression in adult rat lung. Yano T, etal., Am J Physiol Lung Cell Mol Physiol. 2000 Dec;279(6):L1146-58.
43. Serum CC-10 in inflammatory lung diseases. Ye Q, etal., Respiration. 2004 Sep-Oct;71(5):505-10.
44. Clara cell secretory protein and phospholipase A2 activity modulate acute ventilator-induced lung injury in mice. Yoshikawa S, etal., J Appl Physiol. 2005 Apr;98(4):1264-71. Epub 2004 Dec 17.
Additional References at PubMed
PMID:1560460   PMID:2349092   PMID:8813084   PMID:11724907   PMID:15356574   PMID:15489334   PMID:18156603   PMID:18303626   PMID:19080379   PMID:21805676   PMID:23533145  


Genomics

Comparative Map Data
Scgb1a1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81215,406,138 - 215,409,686 (-)NCBIGRCr8
mRatBN7.21205,977,060 - 205,980,610 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1205,977,060 - 205,980,610 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1214,394,838 - 214,398,402 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01221,420,410 - 221,423,956 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01214,109,801 - 214,113,347 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01225,279,698 - 225,283,246 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1225,279,676 - 225,283,326 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01232,216,740 - 232,220,289 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41211,758,103 - 211,761,651 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11211,916,532 - 211,920,081 (-)NCBI
Celera1203,487,454 - 203,490,852 (-)NCBICelera
Cytogenetic Map1q43NCBI
SCGB1A1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381162,419,033 - 62,423,195 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1162,405,103 - 62,423,195 (+)EnsemblGRCh38hg38GRCh38
GRCh371162,186,505 - 62,190,667 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361161,943,099 - 61,947,243 (+)NCBINCBI36Build 36hg18NCBI36
Build 341161,943,098 - 61,947,242NCBI
Celera1159,515,913 - 59,520,084 (+)NCBICelera
Cytogenetic Map11q12.3NCBI
HuRef1158,514,572 - 58,518,782 (+)NCBIHuRef
CHM1_11162,069,549 - 62,073,720 (+)NCBICHM1_1
T2T-CHM13v2.01162,408,482 - 62,412,645 (+)NCBIT2T-CHM13v2.0
Scgb1a1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39199,061,006 - 9,065,320 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl199,061,000 - 9,065,322 (-)EnsemblGRCm39 Ensembl
GRCm38199,083,642 - 9,087,956 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl199,083,636 - 9,087,958 (-)EnsemblGRCm38mm10GRCm38
MGSCv37199,158,132 - 9,162,446 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36199,150,685 - 9,154,970 (-)NCBIMGSCv36mm8
Celera198,844,116 - 8,848,457 (-)NCBICelera
Cytogenetic Map19ANCBI
cM Map196.05NCBI
Scgb1a1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_004955599688,414 - 690,644 (-)NCBIChiLan1.0ChiLan1.0
SCGB1A1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2963,645,561 - 63,650,596 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11164,688,256 - 64,692,701 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01157,774,560 - 57,780,334 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11161,133,649 - 61,137,873 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1161,133,649 - 61,137,873 (+)Ensemblpanpan1.1panPan2
SCGB1A1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11854,187,487 - 54,191,493 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1854,187,487 - 54,191,482 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1852,793,067 - 52,797,104 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01855,241,059 - 55,245,094 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1855,241,056 - 55,291,719 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11854,337,711 - 54,341,743 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01853,911,158 - 53,915,170 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01854,707,616 - 54,711,643 (-)NCBIUU_Cfam_GSD_1.0
Scgb1a1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494710,684,916 - 10,687,790 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936581798,739 - 801,633 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936581798,738 - 801,614 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SCGB1A1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl29,297,283 - 9,302,165 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.129,297,282 - 9,302,204 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.228,570,790 - 8,575,683 (+)NCBISscrofa10.2Sscrofa10.2susScr3
SCGB1A1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1111,470,091 - 11,474,915 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl111,470,195 - 11,474,149 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666038108,816,965 - 108,820,794 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Scgb1a1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046249261,029,120 - 1,030,250 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Scgb1a1
33 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:71
Count of miRNA genes:55
Interacting mature miRNAs:55
Transcripts:ENSRNOT00000027342
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1578780Cm52Cardiac mass QTL 523.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)181591954219808434Rat
731168Bp154Blood pressure QTL 1543.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)194642644214537671Rat
1354606Bp246Blood pressure QTL 2463.6arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)1102813953218753816Rat
7794788Mcs32Mammary carcinoma susceptibility QTL 322.61mammary gland integrity trait (VT:0010552)mammary tumor incidence/prevalence measurement (CMO:0000946)1115540693238914717Rat
7421630Bp362Blood pressure QTL 3620.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1118608292241799120Rat
1598853Memor3Memory QTL 34.5exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)1143506580212458660Rat
737828Hcas3Hepatocarcinoma susceptibility QTL 34.9liver integrity trait (VT:0010547)liver tumorous lesion volume to total liver volume ratio (CMO:0001082)1144267353222987745Rat
2302378Insul11Insulin level QTL 113.25blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1144267353251128347Rat
7771612Cm80Cardiac mass QTL 808.4heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)1149448574221264292Rat
724531Uae5Urinary albumin excretion QTL 54urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)1150700142252085212Rat
1578759Uae30Urinary albumin excretion QTL 303.30.003urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1150700247252085048Rat
1578778Pur4Proteinuria QTL 43.30.003urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)1150700247252085048Rat
1354610Bw34Body weight QTL 344.1body mass (VT:0001259)body weight (CMO:0000012)1151162512256448636Rat
1354646Kidm18Kidney mass QTL 185.7kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1151162512256448636Rat
1354661Bw33Body weight QTL 335.2body mass (VT:0001259)body weight (CMO:0000012)1151162512256448636Rat
1358886Bp260Blood pressure QTL 2603.67arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1151162766225824951Rat
1549837Hcar15Hepatocarcinoma resistance QTL 150.05liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1153136852260522016Rat
2312420Pur17Proteinuria QTL 177.10.0001urine protein amount (VT:0005160)urine total protein excretion rate (CMO:0000756)1156677124218753816Rat
1354580Scort1Serum corticosterone level QTL 13.4blood corticosterone amount (VT:0005345)blood corticosterone level (CMO:0001172)1156677124256448636Rat
2292222Bp307Blood pressure QTL 3073.060.0014arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1164310393213533942Rat
2292220Bp306Blood pressure QTL 3063.470.00087arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1164310393243914901Rat
619613Bp77Blood pressure QTL 770.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1164747424209747424Rat
619613Bp77Blood pressure QTL 770.01arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1164747424209747424Rat
1354653Despr9Despair related QTL 90.00019locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)1167909849212909849Rat
61341Bp26Blood pressure QTL 26arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1169537671214537671Rat
724562Rends1Renal damage susceptibility QTL 10.05kidney glomerulus integrity trait (VT:0010546)index of glomerular damage (CMO:0001135)1169537671214537671Rat
1358294Bw37Body weight QTL 3750.000011body mass (VT:0001259)body weight (CMO:0000012)1171310381216310381Rat
2293689Bss47Bone structure and strength QTL 477.250.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra trabecular cross-sectional area (CMO:0001692)1171629477216629477Rat
2293693Bss22Bone structure and strength QTL 2233.520.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)1171629477216629477Rat
2300161Bmd43Bone mineral density QTL 438.40.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)1171629477216629477Rat
2300174Bmd42Bone mineral density QTL 428.40.0001lumbar vertebra mineral mass (VT:0010511)bone mineral density (CMO:0001226)1171629477216629477Rat
2300187Bmd41Bone mineral density QTL 418.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)1171629477216629477Rat
2293654Bss30Bone structure and strength QTL 3032.650.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)1171629477216629477Rat
2293673Bss27Bone structure and strength QTL 2718.630.0001femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)1171629477216629477Rat
2293677Bss41Bone structure and strength QTL 419.380.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra cross-sectional area (CMO:0001689)1171629477216629477Rat
1549830Bss1Bone structure and strength QTL 14.8femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)1172609619217609619Rat
631214Bw61Body weight QTL613.40.0001intramuscular adipose amount (VT:0010044)intramuscular fat area (CMO:0001162)1173108781218108781Rat
70163Bw20Body weight QTL 205.1body mass (VT:0001259)body weight (CMO:0000012)1174133260219133260Rat
738032Hcas5Hepatocarcinoma susceptibility QTL 53.12liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1176426412257976495Rat
1600380Niddm70Non-insulin dependent diabetes mellitus QTL 703.10.0008blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)1176550523221550523Rat
10059600Bp378Blood pressure QTL 3783.080.05arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1176869060221869060Rat
1354624Cm35Cardiac mass QTL355.7heart left ventricle mass (VT:0007031)calculated heart weight (CMO:0000073)1177227632256448636Rat
1354652Kidm20Kidney mass QTL 204.3kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1177227632256448636Rat
1558658Bw59Body weight QTL 593.50.0003body mass (VT:0001259)body weight (CMO:0000012)1178784622223784622Rat
634321Hc1Hypercalciuria QTL 12.91urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)1178810256240830002Rat
1578763Kidm29Kidney mass QTL 293.30.0001kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1179567751260522016Rat
1302787Stl25Serum triglyceride level QTL 252.70.0073blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)1180359209210702199Rat
6903303Scl34Serum cholesterol QTL 342.50.0033blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)1180359209218108781Rat
737977Bp160Blood pressure QTL 1600.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1181133855226133855Rat
724559Pancm1Pancreatic morphology QTL 17.1islet of Langerhans morphology trait (VT:0005215)pancreatic islet damage composite score (CMO:0001156)1181759564214537555Rat
2293083Iddm25Insulin dependent diabetes mellitus QTL 254.18blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1181829673224569684Rat
634312Bp143Blood pressure QTL 14330.0002arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1182623426219932796Rat
8655655Arrd2Age-related retinal degeneration QTL 27.79retinal layer morphology trait (VT:0003727)percentage of study population developing retinopathy during a period of time (CMO:0002453)1183970203243914901Rat
8655855Arrd3Age-related retinal degeneration QTL 33.07lens clarity trait (VT:0001304)cataract incidence/prevalence measurement (CMO:0001585)1183970203243914901Rat
631838Niddm36Non-insulin dependent diabetes mellitus QTL 360.01insulin secretion trait (VT:0003564)calculated pancreatic islet insulin release measurement (CMO:0001217)1184550676229550676Rat
1300145Rf7Renal function QTL 72.96urine creatinine amount (VT:0010540)urine creatinine level (CMO:0000125)1185145134221264292Rat
2312564Glom18Glomerulus QTL 182.40.003kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)1185356336231689108Rat
1582206Kidm33Kidney mass QTL 336.9kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1188377360224054420Rat
1358898Bp255Blood pressure QTL 2553.6arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1191019702246062233Rat
10059590Kidm44Kidney mass QTL 443.420.025kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1191033875236033875Rat
1358191Ept10Estrogen-induced pituitary tumorigenesis QTL 103.8pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)1192825253243914732Rat
8552891Epfw5Epididymal fat weight QTL 54.4epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)1193113876238113876Rat
634338Hcar4Hepatocarcinoma resistance QTL 44.6liver integrity trait (VT:0010547)liver tumorous lesion number to liver area ratio (CMO:0001210)1193422268214537671Rat
1600388Niddm67Non-insulin dependent diabetes mellitus QTL 675.840.000004blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1195804352257091168Rat
1600395Niddm69Non-insulin dependent diabetes mellitus QTL 694.140.0002blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)1195804352257091168Rat
1600396Niddm68Non-insulin dependent diabetes mellitus QTL 684.970.0003blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1195804352257091168Rat
631658Cm7Cardiac mass QTL 75.320.0001aorta mass (VT:0002845)aorta weight (CMO:0000076)1196248093241248093Rat
1358292Cm37Cardiac mass QTL 376.20.00000081heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)1196248093241248093Rat
1600374Mcs17Mammary carcinoma susceptibility QTL 173mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1197670404242670404Rat
1641926Teswt2Testicular weight QTL 22.82testis mass (VT:1000644)both testes wet weight (CMO:0000175)1197697768238755659Rat
2302375Bw83Body weight QTL 834.870.0002body mass (VT:0001259)body weight (CMO:0000012)1197697768242697768Rat
61376Bp42Blood pressure QTL 4223.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1197814409242814409Rat
1298084Thym4Thymus enlargement QTL 410.68thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)1197814409242814409Rat
1357335Bw39Body weight QTL 393.3body mass (VT:0001259)body weight (CMO:0000012)1197814409242814409Rat
1331790Bp201Blood pressure QTL 2013.127arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1198211513225126682Rat
634313Niddm43Non-insulin dependent diabetes mellitus QTL 43blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1199050459259647894Rat
2292218Kidm35Kidney mass QTL 35kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1199368955224569684Rat
2293694Bss38Bone structure and strength QTL 387.050.0001femur strength trait (VT:0010010)femur stiffness (CMO:0001674)1201554356246554356Rat
7394701Uae46Urinary albumin excretion QTL 463.60.0056urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1201554356246554356Rat
2300175Bmd40Bone mineral density QTL 4015.40.0001femur mineral mass (VT:0010011)bone mineral density (CMO:0001226)1201554356246554356Rat
2293655Bss36Bone structure and strength QTL 3610.660.0001femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)1201554356246554356Rat
2293674Bss39Bone structure and strength QTL 397.10.0001femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)1201554356246554356Rat
10059587Bw173Body weight QTL 1733.230.025body mass (VT:0001259)body weight (CMO:0000012)1202069611247069611Rat
1600363Hc6Hypercalciuria QTL 62.7urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)1203995416244113296Rat

Markers in Region
RH134311  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21205,977,071 - 205,978,692 (+)MAPPERmRatBN7.2
Rnor_6.01225,279,710 - 225,281,328NCBIRnor6.0
Rnor_5.01232,216,752 - 232,218,371UniSTSRnor5.0
RGSC_v3.41211,758,115 - 211,759,733UniSTSRGSC3.4
Celera1203,487,466 - 203,488,934UniSTS
RH 3.4 Map11520.7UniSTS
Cytogenetic Map1q43UniSTS
D1Bda50  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21205,980,205 - 205,980,438 (+)MAPPERmRatBN7.2
Rnor_6.01225,282,842 - 225,283,074NCBIRnor6.0
Rnor_5.01232,219,885 - 232,220,117UniSTSRnor5.0
RGSC_v3.41211,761,247 - 211,761,479UniSTSRGSC3.4
Celera1203,490,448 - 203,490,680UniSTS
Cytogenetic Map1q43UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High 11
Medium 4 1 2
Low 1 11 23 7 19 7 8 10 11 7 10 8
Below cutoff 1 8 5 5 5 1 2 16

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000027342   ⟹   ENSRNOP00000027342
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1205,977,060 - 205,980,610 (-)Ensembl
Rnor_6.0 Ensembl1225,279,676 - 225,283,326 (-)Ensembl
RefSeq Acc Id: NM_013051   ⟹   NP_037183
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81215,406,138 - 215,409,686 (-)NCBI
mRatBN7.21205,977,060 - 205,980,610 (-)NCBI
Rnor_6.01225,279,698 - 225,283,246 (-)NCBI
Rnor_5.01232,216,740 - 232,220,289 (-)NCBI
RGSC_v3.41211,758,103 - 211,761,651 (-)RGD
Celera1203,487,454 - 203,490,852 (-)RGD
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_037183   ⟸   NM_013051
- Peptide Label: precursor
- UniProtKB: P17559 (UniProtKB/Swiss-Prot),   A6HZZ1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000027342   ⟸   ENSRNOT00000027342

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P17559-F1-model_v2 AlphaFold P17559 1-96 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13690754
Promoter ID:EPDNEW_R1279
Type:single initiation site
Name:Scgb1a1_1
Description:secretoglobin family 1A member 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01225,283,254 - 225,283,314EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3934 AgrOrtholog
BioCyc Gene G2FUF-56467 BioCyc
Ensembl Genes ENSRNOG00000020196 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOG00055017842 UniProtKB/Swiss-Prot
  ENSRNOG00060033198 UniProtKB/Swiss-Prot
  ENSRNOG00065033930 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000027342 ENTREZGENE
  ENSRNOT00000027342.4 UniProtKB/Swiss-Prot
  ENSRNOT00055030180 UniProtKB/Swiss-Prot
  ENSRNOT00060057557 UniProtKB/Swiss-Prot
  ENSRNOT00065058261 UniProtKB/Swiss-Prot
Gene3D-CATH Secretoglobin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7096714 IMAGE-MGC_LOAD
InterPro Secretoglobin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Secretoglobin_1C-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Secretoglobin_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Uteroglobin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:25575 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:91765 IMAGE-MGC_LOAD
NCBI Gene 25575 ENTREZGENE
PANTHER PTHR10136 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  UTEROGLOBIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Uteroglobin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Scgb1a1 PhenoGen
PRINTS UTEROGLOBIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE SCGB UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000020196 RatGTEx
  ENSRNOG00055017842 RatGTEx
  ENSRNOG00060033198 RatGTEx
  ENSRNOG00065033930 RatGTEx
SMART UTG UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF48201 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR TC216749
UniProt A6HZZ1 ENTREZGENE, UniProtKB/TrEMBL
  P17559 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-01-13 Scgb1a1  secretoglobin family 1A member 1  Scgb1a1  secretoglobin, family 1A, member 1 (uteroglobin)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-09-10 Scgb1a1  secretoglobin, family 1A, member 1 (uteroglobin)    secretoglobin, family 1A, member 1  Name updated 1299863 APPROVED
2003-04-09 Scgb1a1  secretoglobin, family 1A, member 1  Ugb  Uteroglobin (Clara cell secretory protein)  Symbol and Name updated 629477 APPROVED
2002-06-10 Ugb  Uteroglobin (Clara cell secretory protein)      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_cellular_localization secreted by the mucosal epithelium 628342
gene_expression expressed in lungs, uterus, prostate and breast and in some nongranulated secretory cells and some goblet cells 628342
gene_protein 16 kDa homodimeric protein 628342
gene_regulation expression in nongranulated secretory cells is induced by interleukin (IL)-13 and occurs via an EGFR signaling pathway 628342