Ucn (urocortin) - Rat Genome Database

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Gene: Ucn (urocortin) Rattus norvegicus
Analyze
Symbol: Ucn
Name: urocortin
RGD ID: 3929
Description: Enables corticotropin-releasing hormone receptor 1 binding activity; corticotropin-releasing hormone receptor 2 binding activity; and histone deacetylase inhibitor activity. Involved in several processes, including negative regulation of cell size; positive regulation of macromolecule metabolic process; and regulation of hormone secretion. Located in axon; dendrite; and perikaryon. Used to study Parkinsonism and thromboangiitis obliterans. Biomarker of asthma; colitis; and thromboangiitis obliterans. Orthologous to human UCN (urocortin); PARTICIPATES IN corticotropin-releasing hormone signaling pathway; INTERACTS WITH 6-propyl-2-thiouracil; ammonium chloride; astressin.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: corticotensin
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8630,958,086 - 30,958,916 (+)NCBIGRCr8
mRatBN7.2625,238,120 - 25,238,950 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl625,238,120 - 25,238,950 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx625,538,943 - 25,539,773 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0625,854,837 - 25,855,667 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0625,333,721 - 25,334,551 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0626,602,144 - 26,602,974 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl626,602,144 - 26,602,974 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0636,418,524 - 36,419,354 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4625,216,788 - 25,217,618 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1625,219,740 - 25,220,571 (+)NCBI
Celera624,729,244 - 24,730,074 (+)NCBICelera
Cytogenetic Map6q14NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
activation of protein kinase A activity  (IDA)
aerobic respiration  (IDA)
associative learning  (IDA)
drinking behavior  (IMP)
feeding behavior  (IMP)
female pregnancy  (IEP)
learning or memory  (IDA)
negative regulation of apoptotic process  (IDA)
negative regulation of appetite  (IDA)
negative regulation of blood pressure  (IDA)
negative regulation of cell size  (IDA)
negative regulation of cellular process  (IDA)
negative regulation of feeding behavior  (IBA,IDA)
negative regulation of gene expression  (IDA)
negative regulation of hormone secretion  (IDA)
negative regulation of neuron apoptotic process  (IDA)
neuron projection development  (IDA)
neuropeptide signaling pathway  (IDA)
positive regulation of behavioral fear response  (IDA)
positive regulation of calcium ion import  (IDA)
positive regulation of cAMP-mediated signaling  (IDA)
positive regulation of cardiac muscle contraction  (IDA)
positive regulation of cell growth  (IDA)
positive regulation of cellular process  (IDA)
positive regulation of collagen biosynthetic process  (IDA)
positive regulation of corticotropin secretion  (IDA,ISO)
positive regulation of DNA replication  (IDA)
positive regulation of gene expression  (IDA)
positive regulation of interleukin-6 production  (IDA)
positive regulation of peptidyl-serine phosphorylation  (IDA)
positive regulation of protein phosphorylation  (IDA)
positive regulation of transcription by RNA polymerase II  (ISO)
positive regulation of translation  (IDA)
positive regulation of vascular permeability  (IDA)
prepulse inhibition  (ISO)
regulation of synaptic transmission, glutamatergic  (IDA)
response to auditory stimulus  (ISO)
response to estradiol  (IEP)
response to glucocorticoid  (IEP)
response to immobilization stress  (ISO)
response to oxidative stress  (IDA)
response to pain  (IEP)
response to starvation  (ISO)
sensory perception of sound  (IEA)
social behavior  (IDA)
startle response  (ISO)
vasodilation  (IDA)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Analysis of the mechanism of the vasodepressor effect of urocortin in anesthetized rats. Abdelrahman AM, etal., Pharmacology. 2005 Mar;73(4):175-9. Epub 2004 Dec 14.
2. Urocortin expression in rat brain: evidence against a pervasive relationship of urocortin-containing projections with targets bearing type 2 CRF receptors. Bittencourt JC, etal., J Comp Neurol. 1999 Dec 20;415(3):285-312.
3. Urocortin induces positive inotropic effect in rat heart. Calderon-Sanchez E, etal., Cardiovasc Res. 2009 Sep 1;83(4):717-25. Epub 2009 May 21.
4. Hypertrophic effects of urocortin homologous peptides are mediated via activation of the Akt pathway. Chanalaris A, etal., Biochem Biophys Res Commun. 2005 Mar 11;328(2):442-8.
5. Protective effects of the urocortin homologues stresscopin (SCP) and stresscopin-related peptide (SRP) against hypoxia/reoxygenation injury in rat neonatal cardiomyocytes. Chanalaris A, etal., J Mol Cell Cardiol. 2003 Oct;35(10):1295-305.
6. Possible role of CRF peptides in burn-induced hypermetabolism. Chance WT, etal., Life Sci. 2006 Jan 11;78(7):694-703. Epub 2005 Aug 24.
7. Urocortin 1 modulates immunosignaling in a rat model of colitis via corticotropin-releasing factor receptor 2. Chang J, etal., Am J Physiol Gastrointest Liver Physiol. 2011 May;300(5):G884-94. Epub 2011 Feb 17.
8. Genetically encoded chemical probes in cells reveal the binding path of urocortin-I to CRF class B GPCR. Coin I, etal., Cell. 2013 Dec 5;155(6):1258-69. doi: 10.1016/j.cell.2013.11.008. Epub 2013 Nov 27.
9. Local secretion of urocortin 1 promotes microvascular permeability during lipopolysaccharide-induced inflammation. Cureton EL, etal., Endocrinology. 2009 Dec;150(12):5428-37. Epub 2009 Oct 9.
10. Hypothalamic paraventricular nucleus injections of urocortin alter food intake and respiratory quotient. Currie PJ, etal., Brain Res. 2001 Oct 19;916(1-2):222-8.
11. Reduced urocortin 1 immunoreactivity in the non-preganglionic Edinger-Westphal nucleus during late pregnancy in rats. Fatima A, etal., Regul Pept. 2007 Oct 4;143(1-3):34-8. Epub 2007 Mar 1.
12. High maternal and fetal plasma urocortin levels in pregnancies complicated by hypertension. Florio P, etal., J Hypertens. 2006 Sep;24(9):1831-40.
13. Mechanisms of the protective effects of urocortin on coronary endothelial function during ischemia-reperfusion in rat isolated hearts. Garcia-Villalon AL, etal., Br J Pharmacol. 2005 Jun;145(4):490-4.
14. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
15. Urocortins and CCK-8 Act Synergistically to Increase Satiation in Lean but not Obese Mice: Involvement of CRF2 Pathway. Gourcerol G, etal., Endocrinology. 2007 Oct 11;.
16. Stimulation of rat pancreatic exocrine secretion by urocortin and corticotropin releasing factor. Guzman EA, etal., Peptides. 2003 May;24(5):727-34.
17. Estrogen receptors alpha and beta differentially regulate the transcriptional activity of the Urocortin gene. Haeger P, etal., J Neurosci. 2006 May 3;26(18):4908-16.
18. Distribution of corticotropin-releasing factor binding protein-immunoreactivity in the rat hypothalamus: association with corticotropin-releasing factor-, urocortin 1- and vimentin-immunoreactive fibres. Henry BA, etal., J Neuroendocrinol. 2005 Mar;17(3):135-44.
19. The molecular mechanisms underlying the regulation of the biological activity of corticotropin-releasing hormone receptors: implications for physiology and pathophysiology. Hillhouse EW and Grammatopoulos DK, Endocr Rev. 2006 May;27(3):260-86. Epub 2006 Feb 16.
20. Ligand affinity for amino-terminal and juxtamembrane domains of the corticotropin releasing factor type I receptor: regulation by G-protein and nonpeptide antagonists. Hoare SR, etal., Biochemistry. 2004 Apr 6;43(13):3996-4011.
21. Urocortin modulates dopaminergic neuronal survival via inhibition of glycogen synthase kinase-3beta and histone deacetylase. Huang HY, etal., Neurobiol Aging. 2011 Sep;32(9):1662-77. Epub 2009 Oct 28.
22. Cardiac expression of urocortin (Ucn) in diseased heart; preliminary results on possible involvement of Ucn in pathophysiology of cardiac diseases. Ikeda K, etal., Mol Cell Biochem. 2003 Oct;252(1-2):25-32.
23. Urocortin-related peptides increase interleukin-6 output via cyclic adenosine 5'-monophosphate-dependent pathways in A7r5 aortic smooth muscle cells. Kageyama K and Suda T, Endocrinology. 2003 Jun;144(6):2234-41.
24. Modulation of Ca2+ influx by corticotropin-releasing factor (CRF) family of peptides via CRF receptors in rat pancreatic beta-cells. Kageyama K, etal., Peptides. 2006 Jul;27(7):1814-9. Epub 2006 Feb 28.
25. Urocortin. Latchman DS, Int J Biochem Cell Biol. 2002 Aug;34(8):907-10.
26. Urocortin protects cardiac myocytes from ischemia/reperfusion injury by attenuating calcium-insensitive phospholipase A2 gene expression. Lawrence KM, etal., FASEB J. 2003 Dec;17(15):2313-5. Epub 2003 Oct 16.
27. Corticotropin-releasing factor and Urocortin I modulate excitatory glutamatergic synaptic transmission. Liu J, etal., J Neurosci. 2004 Apr 21;24(16):4020-9.
28. The use of H-2 mutants as models for the study of T cell activation. McKenzie IF, etal., Immunol Rev 1977;35:179-230.
29. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
30. Role of corticotropin-releasing factor receptor type 2 beta in urocortin-induced vasodilation of rat aortas. Miki I, etal., J Pharmacol Sci. 2004 Oct;96(2):170-6. Epub 2004 Oct 2.
31. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
32. Urocortin, a member of the corticotropin-releasing factor family, in normal and diseased heart. Nishikimi T, etal., Am J Physiol Heart Circ Physiol. 2000 Dec;279(6):H3031-9.
33. Urocortin in the ventromedial hypothalamic nucleus acts as an inhibitor of feeding behavior in rats. Ohata H, etal., Brain Res. 2000 Apr 7;861(1):1-7.
34. Genomic organization and tissue-specific expression of rat urocortin. Park JH, etal., Neurosci Lett 2000 Sep 29;292(1):45-8.
35. Urocortin, but not urocortin II, protects cultured hippocampal neurons from oxidative and excitotoxic cell death via corticotropin-releasing hormone receptor type I. Pedersen WA, etal., J Neurosci 2002 Jan 15;22(2):404-12.
36. Modulation of learning and anxiety by corticotropin-releasing factor (CRF) and stress: differential roles of CRF receptors 1 and 2. Radulovic J, etal., J Neurosci. 1999 Jun 15;19(12):5016-25.
37. Cardiotrophin-1 and urocortin cause protection by the same pathway and hypertrophy via distinct pathways in cardiac myocytes. Railson JE, etal., Cytokine 2002 Mar 7;17(5):243-53.
38. GOA pipeline RGD automated data pipeline
39. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
40. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
41. Differential responses of corticotropin-releasing factor and urocortin 1 to acute pain stress in the rat brain. Rouwette T, etal., Neuroscience. 2011 Jun 2;183:15-24. Epub 2011 Apr 2.
42. Injections of urocortin 1 into the basolateral amygdala induce anxiety-like behavior and c-Fos expression in brainstem serotonergic neurons. Spiga F, etal., Neuroscience. 2006;138(4):1265-76. Epub 2006 Feb 20.
43. Corticotropin-releasing factor and urocortin differentially modulate rat Purkinje cell dendritic outgrowth and differentiation in vitro. Swinny JD, etal., Eur J Neurosci. 2004 Apr;19(7):1749-58.
44. The localisation of urocortin in the adult rat cerebellum: a light and electron microscopic study. Swinny JD, etal., Neuroscience. 2002;114(4):891-903.
45. Cardioprotective activity of urocortin by preventing caspase-independent, non-apoptotic death in cultured neonatal rat cardiomyocytes exposed to ischemia. Takatani-Nakase T and Takahashi K, Biochem Biophys Res Commun. 2010 Nov 12;402(2):216-21. Epub 2010 Oct 8.
46. Urocortin, a mammalian neuropeptide related to fish urotensin I and to corticotropin-releasing factor. Vaughan J, etal., Nature 1995 Nov 16;378(6554):287-92.
47. Odorranalectin-conjugated nanoparticles: preparation, brain delivery and pharmacodynamic study on Parkinson's disease following intranasal administration. Wen Z, etal., J Control Release. 2011 Apr 30;151(2):131-8. Epub 2011 Feb 26.
48. Plasma urocortin 1 in human heart failure. Wright SP, etal., Circ Heart Fail. 2009 Sep;2(5):465-71. Epub 2009 Jul 8.
49. Enhanced expression of urocortin in lung tissues of rats with allergic asthma. Wu Y, etal., Biochem Biophys Res Commun. 2006 Mar 10;341(2):532-40. Epub 2006 Jan 13.
50. Urocortin promotes the development of vasculitis in a rat model of thromboangiitis obliterans via corticotrophin-releasing factor type 1 receptors. Xu Y, etal., Br J Pharmacol. 2009 Aug;157(8):1368-79. Epub 2009 Jun 30.
51. Urocortin 1 reduces food intake and ghrelin secretion via CRF(2) receptors. Yakabi K, etal., Am J Physiol Endocrinol Metab. 2011 Jul;301(1):E72-82. Epub 2011 May 3.
52. Urocortin shares the memory modulating effects of corticotropin-releasing factor (CRF): mediation by CRF1 receptors. Zorrilla EP, etal., Brain Res 2002 Oct 18;952(2):200-10.
Additional References at PubMed
PMID:9423932   PMID:11329063   PMID:11416224   PMID:12091910   PMID:12110614   PMID:12192058   PMID:12559087   PMID:15024751   PMID:15457505   PMID:15979199   PMID:16198122   PMID:16337313  
PMID:16423352   PMID:16650605   PMID:17090973   PMID:17154253   PMID:17478891   PMID:17483234   PMID:17659087   PMID:17947696   PMID:18804421   PMID:19395554   PMID:19426783   PMID:19694731  
PMID:19729048   PMID:19833156   PMID:20237592   PMID:20833218   PMID:21303672   PMID:21621194   PMID:21627635   PMID:22244812   PMID:22432129   PMID:23183626   PMID:23707488   PMID:24064363  
PMID:24856473   PMID:25641682   PMID:26146233   PMID:27045550   PMID:27659706   PMID:27826101   PMID:30422021   PMID:31073117   PMID:32196844  


Genomics

Comparative Map Data
Ucn
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8630,958,086 - 30,958,916 (+)NCBIGRCr8
mRatBN7.2625,238,120 - 25,238,950 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl625,238,120 - 25,238,950 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx625,538,943 - 25,539,773 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0625,854,837 - 25,855,667 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0625,333,721 - 25,334,551 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0626,602,144 - 26,602,974 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl626,602,144 - 26,602,974 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0636,418,524 - 36,419,354 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4625,216,788 - 25,217,618 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1625,219,740 - 25,220,571 (+)NCBI
Celera624,729,244 - 24,730,074 (+)NCBICelera
Cytogenetic Map6q14NCBI
UCN
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38227,307,400 - 27,308,445 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl227,307,400 - 27,308,445 (-)EnsemblGRCh38hg38GRCh38
GRCh37227,530,268 - 27,531,313 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36227,383,769 - 27,384,634 (-)NCBINCBI36Build 36hg18NCBI36
Build 34227,441,915 - 27,442,781NCBI
Celera227,377,369 - 27,378,234 (-)NCBICelera
Cytogenetic Map2p23.3NCBI
HuRef227,272,488 - 27,273,352 (-)NCBIHuRef
CHM1_1227,460,211 - 27,461,076 (-)NCBICHM1_1
T2T-CHM13v2.0227,349,815 - 27,350,860 (-)NCBIT2T-CHM13v2.0
Ucn
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39531,295,333 - 31,296,239 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl531,295,407 - 31,296,173 (-)EnsemblGRCm39 Ensembl
GRCm38531,137,989 - 31,138,895 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl531,138,063 - 31,138,829 (-)EnsemblGRCm38mm10GRCm38
MGSCv37531,440,362 - 31,441,268 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36531,414,570 - 31,415,476 (-)NCBIMGSCv36mm8
Celera528,616,898 - 28,617,804 (-)NCBICelera
Cytogenetic Map5B1NCBI
cM Map517.11NCBI
Ucn
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554699,277,637 - 9,278,641 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554699,277,637 - 9,278,641 (-)NCBIChiLan1.0ChiLan1.0
UCN
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21299,203,119 - 99,205,065 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12A99,207,076 - 99,209,033 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02A27,309,458 - 27,311,268 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12A27,397,175 - 27,399,053 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2A27,397,295 - 27,397,669 (-)Ensemblpanpan1.1panPan2
UCN
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11721,278,512 - 21,280,404 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1721,278,932 - 21,279,312 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1721,170,573 - 21,171,891 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01721,600,051 - 21,601,369 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1721,600,211 - 21,600,591 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11721,286,746 - 21,288,064 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01721,296,246 - 21,297,564 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01721,344,471 - 21,345,789 (-)NCBIUU_Cfam_GSD_1.0
Ucn
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440629265,578,803 - 65,579,918 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364935,260,219 - 5,260,602 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364935,258,574 - 5,260,692 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
UCN
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl3111,835,125 - 111,835,508 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.13111,834,082 - 111,835,932 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
UCN
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11480,303,210 - 80,304,910 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1480,304,416 - 80,304,790 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604531,847,056 - 31,848,892 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ucn
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247389,393,329 - 9,393,706 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247389,393,004 - 9,393,966 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Ucn
2 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:120
Count of miRNA genes:95
Interacting mature miRNAs:102
Transcripts:ENSRNOT00000008037
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
738023Alc17Alcohol consumption QTL 173.10.003consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)6127574569Rat
1354616Despr12Despair related QTL 120.0012locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)6127574569Rat
1549905Stresp10Stress response QTL 106.830.0066stress-related behavior trait (VT:0010451)number of approaches toward negative stimulus before onset of defensive burying response (CMO:0001960)6127574569Rat
2300176Bmd51Bone mineral density QTL 5111.70.0001femur mineral mass (VT:0010011)bone mineral density (CMO:0001226)6127574569Rat
2300190Bmd52Bone mineral density QTL 5211.20.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)6127574569Rat
1331743Uae28Urinary albumin excretion QTL 284.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)6134235784Rat
1578758Tcas9Tongue tumor susceptibility QTL 93.29tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)6137618905Rat
1598843Cm63Cardiac mass QTL 632.6heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)6139036266Rat
7411603Foco13Food consumption QTL 135.50.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)6141223769Rat
8552962Pigfal16Plasma insulin-like growth factor 1 level QTL 169.4blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)6141223769Rat
7411542Bw127Body weight QTL 1275.50.001body mass (VT:0001259)body weight gain (CMO:0000420)6141223769Rat
9589129Insul24Insulin level QTL 2419.060.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)6141223769Rat
9589048Scfw3Subcutaneous fat weight QTL 34.570.001subcutaneous adipose mass (VT:1000472)abdominal subcutaneous fat pad weight (CMO:0002069)6141223769Rat
2293709Bss23Bone structure and strength QTL 235.180.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)6142487980Rat
2293650Bss31Bone structure and strength QTL 315.050.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)6142487980Rat
2293656Bss28Bone structure and strength QTL 286.790.0001femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)6142487980Rat
7411584Foco4Food consumption QTL 44.30.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)6142838846Rat
738024Sach5Saccharine consumption QTL 53.90.00039consumption behavior trait (VT:0002069)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)6143394190Rat
2301972Bp325Blood pressure QTL 3254.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)6172227641Rat
1300128Rf16Renal function QTL 163.89renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)6507449734434305Rat
1300164Rf15Renal function QTL 153.12renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)6507449754641141Rat
4145119Mcs25Mammary carcinoma susceptibility QTL 250.0001mammary gland integrity trait (VT:0010552)ratio of deaths to total study population during a period of time (CMO:0001023)610894415110548006Rat
1578665Bss16Bone structure and strength QTL 164.4femur morphology trait (VT:0000559)bone trabecular cross-sectional area (CMO:0002311)61173566972593685Rat
1578668Bmd14Bone mineral density QTL 143.8femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)61173566972593685Rat
10401812Kidm54Kidney mass QTL 54kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)61436878859368788Rat
10401800Kidm49Kidney mass QTL 49kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)61436878859368788Rat
1576309Emca7Estrogen-induced mammary cancer QTL 74mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)615107216107351382Rat
1359023Bp272Blood pressure QTL 2722.5arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)61653614027261739Rat
2292589Emca10Estrogen-induced mammary cancer QTL 100.048mammary gland integrity trait (VT:0010552)post-insult time to mammary tumor formation (CMO:0000345)61653614061536140Rat
1354664Slep2Serum leptin concentration QTL 24.49blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)61653614071636405Rat
1641898Colcr4Colorectal carcinoma resistance QTL43.710.0007intestine integrity trait (VT:0010554)well differentiated malignant colorectal tumor surface area measurement (CMO:0002077)62033877762613667Rat
2293839Kiddil2Kidney dilation QTL 24.8kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)62086642281133036Rat
2293841Kiddil4Kidney dilation QTL 44.4kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)62086642281133036Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium
Low 10 8 11 5 2 8
Below cutoff 1 5 5 1 8 1 23 3 13 8

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000008037   ⟹   ENSRNOP00000008037
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl625,238,120 - 25,238,950 (+)Ensembl
Rnor_6.0 Ensembl626,602,144 - 26,602,974 (+)Ensembl
RefSeq Acc Id: NM_019150   ⟹   NP_062023
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8630,958,086 - 30,958,916 (+)NCBI
mRatBN7.2625,238,120 - 25,238,950 (+)NCBI
Rnor_6.0626,602,144 - 26,602,974 (+)NCBI
Rnor_5.0636,418,524 - 36,419,354 (+)NCBI
RGSC_v3.4625,216,788 - 25,217,618 (+)RGD
Celera624,729,244 - 24,730,074 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_062023 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA87566 (Get FASTA)   NCBI Sequence Viewer  
  AAF63153 (Get FASTA)   NCBI Sequence Viewer  
  EDM02930 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000008037
  ENSRNOP00000008037.1
  ENSRNOP00055027561
  ENSRNOP00060017939
  ENSRNOP00065031765
GenBank Protein P55090 (Get FASTA)   NCBI Sequence Viewer  
Reference Protein Sequences
RefSeq Acc Id: NP_062023   ⟸   NM_019150
- Peptide Label: precursor
- UniProtKB: P55090 (UniProtKB/Swiss-Prot),   A6HA75 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000008037   ⟸   ENSRNOT00000008037
Protein Domains
Corticotropin-releasing factor

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P55090-F1-model_v2 AlphaFold P55090 1-122 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3929 AgrOrtholog
BioCyc Gene G2FUF-38346 BioCyc
Ensembl Genes ENSRNOG00000006090 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOG00055019865 UniProtKB/Swiss-Prot
  ENSRNOG00060013274 UniProtKB/Swiss-Prot
  ENSRNOG00065022893 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000008037 ENTREZGENE
  ENSRNOT00000008037.3 UniProtKB/Swiss-Prot
  ENSRNOT00055033939 UniProtKB/Swiss-Prot
  ENSRNOT00060022619 UniProtKB/Swiss-Prot
  ENSRNOT00065039111 UniProtKB/Swiss-Prot
Gene3D-CATH 6.10.250.1920 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Corticotropin-releasing_fac_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CRF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Urocortin_CRF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:29151 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 29151 ENTREZGENE
PANTHER CORTICOLIBERIN/UROCORTIN UniProtKB/TrEMBL, UniProtKB/Swiss-Prot
  UROCORTIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam CRF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB UCN RGD
PhenoGen Ucn PhenoGen
PRINTS CRFFAMILY UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE CRF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000006090 RatGTEx
  ENSRNOG00055019865 RatGTEx
  ENSRNOG00060013274 RatGTEx
  ENSRNOG00065022893 RatGTEx
SMART CRF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A6HA75 ENTREZGENE, UniProtKB/TrEMBL
  P55090 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-06-10 Ucn  urocortin      Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_process protects hippocampal neurons from stress induced injury through binding corticotropin hormone receptor 1 70047
gene_process protects hippocampal neurons from stress induced injury through binding corticotropin hormone receptor 1 70397