RGD Reference Report - Reduced urocortin 1 immunoreactivity in the non-preganglionic Edinger-Westphal nucleus during late pregnancy in rats. - Rat Genome Database

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Reduced urocortin 1 immunoreactivity in the non-preganglionic Edinger-Westphal nucleus during late pregnancy in rats.

Authors: Fatima, A  Haroon, MF  Wolf, G  Engelmann, M  Spina, MG 
Citation: Fatima A, etal., Regul Pept. 2007 Oct 4;143(1-3):34-8. Epub 2007 Mar 1.
RGD ID: 1642779
Pubmed: PMID:17391780   (View Abstract at PubMed)
DOI: DOI:10.1016/j.regpep.2007.02.010   (Journal Full-text)

Pregnancy is accompanied by an array of adaptive changes that play an important role in pre- and postnatal events. In rats, urocortin 1, a corticotropin-releasing factor-like peptide, is expressed mainly in the non-preganglionic Edinger-Westphal nucleus. We investigated the number of neurons immunoreactive for urocortin 1 at three different levels of the Edinger-Westphal nucleus in female rats by immunohistochemistry. The number of urocortin 1 immunoreactive cells was found to be decreased in pregnant rats compared to virgin rats. These results indicate that the hormonal status of the female rat affects urocortin 1 immunoreactive neurons in the non-preganglionic Edinger-Westphal nucleus and its signaling to target brain areas.

Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
female pregnancy  IEP 1642779 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Ucn  (urocortin)


Additional Information