Ttpa (alpha tocopherol transfer protein) - Rat Genome Database

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Gene: Ttpa (alpha tocopherol transfer protein) Rattus norvegicus
Analyze
Symbol: Ttpa
Name: alpha tocopherol transfer protein
RGD ID: 3915
Description: Enables vitamin E binding activity. Involved in several processes, including intracellular pH reduction; negative regulation of epithelial cell apoptotic process; and response to pH. Located in late endosome. Biomarker of liver benign neoplasm. Human ortholog(s) of this gene implicated in familial isolated deficiency of vitamin E. Orthologous to human TTPA (alpha tocopherol transfer protein); INTERACTS WITH (+)-schisandrin B; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: alpha-tocopherol transfer protein; alpha-tocopherol transfer protein-like; alpha-TTP; LOC100909929; tocopherol (alpha) transfer protein; Tocopherol transfer protein alpha; TTP
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8538,294,415 - 38,315,471 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl538,292,665 - 38,315,804 (+)EnsemblGRCr8
mRatBN7.2533,497,537 - 33,518,936 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl533,497,137 - 33,518,073 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx535,611,035 - 35,631,425 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0537,203,240 - 37,223,637 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0537,142,746 - 37,163,146 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0534,007,926 - 34,029,315 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl534,007,920 - 34,028,452 (+)Ensemblrn6Rnor6.0
Rnor_5.0538,661,259 - 38,681,785 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4534,638,551 - 34,659,077 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera532,573,008 - 32,593,536 (+)NCBICelera
RGSC_v3.1534,638,729 - 34,659,256 (+)NCBI
Cytogenetic Map5q13NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(1->4)-beta-D-glucan  (ISO)
1,2,4-trichloro-5-(2,5-dichlorophenyl)benzene  (ISO)
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (EXP,ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,4'-trichlorobiphenyl  (ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
3H-1,2-dithiole-3-thione  (EXP)
4,4'-sulfonyldiphenol  (ISO)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
aflatoxin B1  (ISO)
ammonium chloride  (EXP)
antirheumatic drug  (ISO)
benzo[a]pyrene  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
CGP 52608  (ISO)
chromium atom  (ISO)
cyclosporin A  (ISO)
dicrotophos  (ISO)
dieldrin  (EXP)
doxorubicin  (ISO)
endosulfan  (EXP)
ethanol  (ISO)
flutamide  (EXP)
furan  (EXP)
glafenine  (EXP)
gliotoxin  (EXP)
methapyrilene  (EXP)
methylparaben  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
N-nitrosodiethylamine  (EXP)
N-Nitrosopyrrolidine  (ISO)
nickel sulfate  (ISO)
nicotinic acid  (ISO)
O-methyleugenol  (ISO)
okadaic acid  (ISO)
ozone  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP)
parathion  (ISO)
PCB138  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phenobarbital  (ISO)
potassium dichromate  (ISO)
progesterone  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenite  (EXP,ISO)
Soman  (EXP)
sotorasib  (ISO)
sulforaphane  (ISO)
testosterone  (ISO)
tetrachloroethene  (ISO)
tetrachloromethane  (EXP)
thioacetamide  (EXP)
titanium dioxide  (ISO)
trametinib  (ISO)
trichloroethene  (EXP)
tris(2-butoxyethyl) phosphate  (ISO)
troglitazone  (EXP)
urethane  (ISO)
valproic acid  (ISO)
vitamin E  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IEA)
late endosome  (IBA,IDA)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. alpha-tocopherol transfer protein stimulates the secretion of alpha-tocopherol from a cultured liver cell line through a brefeldin A-insensitive pathway. Arita M, etal., Proc Natl Acad Sci U S A. 1997 Nov 11;94(23):12437-41.
2. alpha-Tocopherol transfer protein expression in rat liver exposed to hyperoxia. Ban R, etal., Free Radic Res. 2002 Sep;36(9):933-8.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
5. pH-dependent translocation of alpha-tocopherol transfer protein (alpha-TTP) between hepatic cytosol and late endosomes. Horiguchi M, etal., Genes Cells. 2003 Oct;8(10):789-800.
6. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
7. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
8. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
9. Ataxia with isolated vitamin E deficiency is caused by mutations in the alpha-tocopherol transfer protein. Ouahchi K, etal., Nat Genet. 1995 Feb;9(2):141-5.
10. GOA pipeline RGD automated data pipeline
11. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
12. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
13. Primary structure of alpha-tocopherol transfer protein from rat liver. Homology with cellular retinaldehyde-binding protein. Sato Y, etal., J Biol Chem 1993 Aug 25;268(24):17705-10.
14. Liver alpha-tocopherol transfer protein and its mRNA are differentially altered by dietary vitamin E deficiency and protein insufficiency in rats. Shaw HM and Huang C, J Nutr. 1998 Dec;128(12):2348-54.
15. A novel role for alpha-tocopherol transfer protein (alpha-TTP) in protecting against chloroquine toxicity. Shichiri M, etal., J Biol Chem. 2012 Jan 20;287(4):2926-34. doi: 10.1074/jbc.M111.321281. Epub 2011 Dec 6.
16. Developmental changes in the expression of alpha-tocopherol transfer protein during the neonatal period of rat. Tamai H, etal., Biofactors. 1998;7(1-2):87-91.
17. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
18. Correlation of repressed transcription of alpha-tocopherol transfer protein with serum alpha-tocopherol during hepatocarcinogenesis. Wu CG, etal., Int J Cancer. 1997 May 16;71(4):686-90.
19. Identification, purification, and immunochemical characterization of a tocopherol-binding protein in rat liver cytosol. Yoshida H, etal., J Lipid Res. 1992 Mar;33(3):343-50.
Additional References at PubMed
PMID:11076932   PMID:11095717   PMID:16014812   PMID:16024914   PMID:16257640   PMID:19923370   PMID:23535541   PMID:23599266   PMID:24231105   PMID:25866300  


Genomics

Comparative Map Data
Ttpa
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8538,294,415 - 38,315,471 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl538,292,665 - 38,315,804 (+)EnsemblGRCr8
mRatBN7.2533,497,537 - 33,518,936 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl533,497,137 - 33,518,073 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx535,611,035 - 35,631,425 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0537,203,240 - 37,223,637 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0537,142,746 - 37,163,146 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0534,007,926 - 34,029,315 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl534,007,920 - 34,028,452 (+)Ensemblrn6Rnor6.0
Rnor_5.0538,661,259 - 38,681,785 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4534,638,551 - 34,659,077 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera532,573,008 - 32,593,536 (+)NCBICelera
RGSC_v3.1534,638,729 - 34,659,256 (+)NCBI
Cytogenetic Map5q13NCBI
TTPA
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38863,058,409 - 63,086,053 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl863,048,553 - 63,086,153 (-)Ensemblhg38GRCh38
GRCh37863,970,968 - 63,998,612 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36864,135,985 - 64,161,166 (-)NCBIBuild 36Build 36hg18NCBI36
Build 34864,135,984 - 64,161,166NCBI
Celera859,962,246 - 59,988,643 (-)NCBICelera
Cytogenetic Map8q12.3NCBI
HuRef859,459,917 - 59,486,481 (-)NCBIHuRef
CHM1_1864,025,060 - 64,051,623 (-)NCBICHM1_1
T2T-CHM13v2.0863,482,981 - 63,510,623 (-)NCBIT2T-CHM13v2.0
Ttpa
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39420,007,889 - 20,030,823 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl420,007,938 - 20,030,785 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38420,007,894 - 20,030,822 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl420,007,938 - 20,030,785 (+)Ensemblmm10GRCm38
MGSCv37419,935,575 - 19,957,932 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36419,935,575 - 19,957,932 (+)NCBIMGSCv36mm8
Celera419,766,254 - 19,788,914 (+)NCBICelera
Cytogenetic Map4A3NCBI
cM Map47.76NCBI
Ttpa
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495544415,869,940 - 15,894,544 (+)Ensembl
ChiLan1.0NW_00495544415,877,972 - 15,891,949 (+)NCBIChiLan1.0ChiLan1.0
TTPA
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2778,785,141 - 78,813,436 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1854,424,191 - 54,452,443 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0859,591,592 - 59,619,658 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1861,266,954 - 61,293,165 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl861,266,954 - 61,293,699 (-)EnsemblpanPan2panpan1.1
TTPA
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12913,177,690 - 13,198,910 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2913,182,308 - 13,192,553 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha2913,507,263 - 13,526,254 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.02913,283,050 - 13,302,075 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2913,283,050 - 13,302,076 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12913,294,501 - 13,313,489 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02913,412,121 - 13,431,143 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02913,677,780 - 13,696,792 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Ttpa
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440530364,318,193 - 64,375,529 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493649610,454,605 - 10,465,301 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493649610,409,948 - 10,466,722 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TTPA
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl470,961,465 - 70,980,876 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1470,960,580 - 70,980,883 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2477,238,492 - 77,250,293 (+)NCBISscrofa10.2Sscrofa10.2susScr3
TTPA
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1858,952,685 - 58,979,083 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl858,950,626 - 58,978,258 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366603982,604,603 - 82,632,422 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ttpa
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474428,713,320 - 28,739,539 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462474428,713,596 - 28,738,435 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Ttpa
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11122,998,219 - 123,019,357 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Ttpa
80 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:231
Count of miRNA genes:152
Interacting mature miRNAs:187
Transcripts:ENSRNOT00000009611
Prediction methods:Microtar, Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2293666Bmd38Bone mineral density QTL 384.4femur size trait (VT:1000369)femoral neck cortical cross-sectional area (CMO:0001702)51373115343590997Rat
1578776Stresp18Stress response QTL 182.9thymus mass (VT:0004954)thymus wet weight (CMO:0000855)53275164977751649Rat
1298067Scl15Serum cholesterol level QTL 154.80.001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)53801167083011670Rat
6907115Mcs29Mammary carcinoma susceptibility QTL 29mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)53800433183004331Rat
1358353Srcrtb2Stress Responsive Cort Basal QTL 23.480.003blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)52367149379046465Rat
70212Niddm25Non-insulin dependent diabetes mellitus QTL 253.54blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)538207390136631402Rat
1300117Hrtrt8Heart rate QTL 83.49heart pumping trait (VT:2000009)heart rate (CMO:0000002)5862723052665523Rat
634305Mamtr1Mammary tumor resistance QTL 10.0001mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)51757663362576633Rat
1578774Tcas8Tongue tumor susceptibility QTL 83.47tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)51570745160707451Rat
1598807Glom12Glomerulus QTL 122.7kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)53801167083011670Rat
1302786Kidm8Kidney mass QTL 828.15kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)53801167083011670Rat
6903292Stl28Serum triglyceride level QTL 282.60.0073blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)53331167378311673Rat
1578767Stresp17Stress response QTL 174.30.01blood aldosterone amount (VT:0005346)plasma aldosterone level (CMO:0000551)53275164977751649Rat
1549901Neudeg2Neurodegradation QTL 240nervous system integrity trait (VT:0010566)mononuclear cell count (CMO:0002119)53113042148841739Rat
1641922Alcrsp8Alcohol response QTL 8alcohol metabolism trait (VT:0015089)blood ethanol level (CMO:0000535)51748608062486080Rat
2313085Bss59Bone structure and strength QTL 592.90.0001long bone metaphysis morphology trait (VT:0000133)tibia midshaft total cross-sectional area (CMO:0001715)5862723053627230Rat
1576314Eutr1Estrogen induced uterine response QTL 1uterus integrity trait (VT:0010575)pyometritis severity score (CMO:0002009)5692228281330203Rat
6903306Scl35Serum cholesterol QTL 352.60.0073blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)53331167378311673Rat
7394712Emca13Estrogen-induced mammary cancer QTL 13mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)51460607859606078Rat
1331771Rf35Renal function QTL 354.36965kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)51001906491770353Rat
8662454Vetf3Vascular elastic tissue fragility QTL 327.4artery integrity trait (VT:0010639)number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)5706553574335773Rat
2290448Scl54Serum cholesterol level QTL 542.93blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)536460764136631402Rat
1641903Alcrsp3Alcohol response QTL 3response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)51748608062486080Rat
1331756Rf34Renal function QTL 344.16275kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)51001906487027358Rat
8552954Pigfal14Plasma insulin-like growth factor 1 level QTL 149blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)52602321171023211Rat
2303577Gluco47Glucose level QTL 473blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)51652001961520019Rat
1600358Mamtr5Mammary tumor resistance QTL 5mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)52367149368671493Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
15 9 65 154 91 90 59 40 59 6 297 134 11 130 81 92 31 14 14

Sequence


Ensembl Acc Id: ENSRNOT00000009611   ⟹   ENSRNOP00000009611
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl538,292,665 - 38,315,468 (+)Ensembl
mRatBN7.2 Ensembl533,497,456 - 33,518,073 (+)Ensembl
Rnor_6.0 Ensembl534,007,920 - 34,028,452 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000103084   ⟹   ENSRNOP00000088814
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl538,294,050 - 38,315,804 (+)Ensembl
mRatBN7.2 Ensembl533,497,137 - 33,518,073 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000149952   ⟹   ENSRNOP00000107412
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl538,294,422 - 38,315,804 (+)Ensembl
RefSeq Acc Id: NM_013048   ⟹   NP_037180
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8538,294,421 - 38,314,941 (+)NCBI
mRatBN7.2533,497,537 - 33,518,073 (+)NCBI
Rnor_6.0534,007,926 - 34,028,452 (+)NCBI
Rnor_5.0538,661,259 - 38,681,785 (+)NCBI
RGSC_v3.4534,638,551 - 34,659,077 (+)RGD
Celera532,573,008 - 32,593,536 (+)RGD
Sequence:
RefSeq Acc Id: XM_017593163   ⟹   XP_017448652
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8538,296,718 - 38,315,471 (+)NCBI
mRatBN7.2533,499,819 - 33,518,936 (+)NCBI
Rnor_6.0534,010,970 - 34,029,315 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017593164   ⟹   XP_017448653
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8538,294,529 - 38,315,471 (+)NCBI
mRatBN7.2533,497,579 - 33,518,936 (+)NCBI
Rnor_6.0534,007,968 - 34,029,315 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039109317   ⟹   XP_038965245
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8538,294,415 - 38,315,471 (+)NCBI
mRatBN7.2533,497,613 - 33,518,936 (+)NCBI
RefSeq Acc Id: XM_039109318   ⟹   XP_038965246
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8538,296,442 - 38,315,471 (+)NCBI
mRatBN7.2533,499,563 - 33,518,936 (+)NCBI
RefSeq Acc Id: XM_039109319   ⟹   XP_038965247
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8538,300,801 - 38,315,471 (+)NCBI
mRatBN7.2533,503,933 - 33,518,936 (+)NCBI
RefSeq Acc Id: XM_063287196   ⟹   XP_063143266
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8538,295,717 - 38,315,471 (+)NCBI
RefSeq Acc Id: NP_037180   ⟸   NM_013048
- UniProtKB: P41034 (UniProtKB/Swiss-Prot),   A0A8L2Q527 (UniProtKB/TrEMBL),   A6IID4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017448653   ⟸   XM_017593164
- Peptide Label: isoform X4
- Sequence:
RefSeq Acc Id: XP_017448652   ⟸   XM_017593163
- Peptide Label: isoform X1
- UniProtKB: A0A8I6GHG2 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000009611   ⟸   ENSRNOT00000009611
RefSeq Acc Id: XP_038965245   ⟸   XM_039109317
- Peptide Label: isoform X3
- UniProtKB: A0A8I6GHG2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038965246   ⟸   XM_039109318
- Peptide Label: isoform X4
RefSeq Acc Id: XP_038965247   ⟸   XM_039109319
- Peptide Label: isoform X5
Ensembl Acc Id: ENSRNOP00000088814   ⟸   ENSRNOT00000103084
RefSeq Acc Id: XP_063143266   ⟸   XM_063287196
- Peptide Label: isoform X2
- UniProtKB: A0A8I6GHG2 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000107412   ⟸   ENSRNOT00000149952
Protein Domains
CRAL-TRIO

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P41034-F1-model_v2 AlphaFold P41034 1-278 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13693591
Promoter ID:EPDNEW_R4116
Type:initiation region
Name:Ttpa_1
Description:alpha tocopherol transfer protein
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0534,007,927 - 34,007,987EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3915 AgrOrtholog
BioCyc Gene G2FUF-41833 BioCyc
Ensembl Genes ENSRNOG00000007139 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000009611 ENTREZGENE
  ENSRNOT00000149952 ENTREZGENE
Gene3D-CATH 3.40.525.10 UniProtKB/Swiss-Prot
  Alpha-tocopherol transfer UniProtKB/Swiss-Prot
  N-terminal domain of phosphatidylinositol transfer protein sec14p UniProtKB/Swiss-Prot
InterPro CRAL-TRIO_dom UniProtKB/Swiss-Prot
  CRAL-TRIO_dom_sf UniProtKB/Swiss-Prot
  CRAL/TRIO_N_dom UniProtKB/Swiss-Prot
  CRAL/TRIO_N_dom_sf UniProtKB/Swiss-Prot
KEGG Report rno:25571 UniProtKB/Swiss-Prot
NCBI Gene 25571 ENTREZGENE
PANTHER ALPHA-TOCOPHEROL TRANSFER PROTEIN UniProtKB/Swiss-Prot
  ALPHA-TOCOPHEROL TRANSFER PROTEIN-RELATED UniProtKB/Swiss-Prot
Pfam CRAL_TRIO UniProtKB/Swiss-Prot
  CRAL_TRIO_N UniProtKB/Swiss-Prot
PhenoGen Ttpa PhenoGen
PRINTS CRETINALDHBP UniProtKB/Swiss-Prot
PROSITE CRAL_TRIO UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000007139 RatGTEx
SMART CRAL_TRIO_N UniProtKB/Swiss-Prot
  SEC14 UniProtKB/Swiss-Prot
Superfamily-SCOP SSF46938 UniProtKB/Swiss-Prot
  SSF52087 UniProtKB/Swiss-Prot
TIGR TC216679
UniProt A0A8I6GHG2 ENTREZGENE, UniProtKB/TrEMBL
  A0A8L2Q527 ENTREZGENE, UniProtKB/TrEMBL
  A0ABK0LZF9_RAT UniProtKB/TrEMBL
  A6IID4 ENTREZGENE, UniProtKB/TrEMBL
  A6IID5 ENTREZGENE, UniProtKB/TrEMBL
  P41034 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-03-09 Ttpa  alpha tocopherol transfer protein  LOC100909929  alpha-tocopherol transfer protein-like  Data merged from RGD:6500944 737654 PROVISIONAL
2016-06-03 Ttpa  alpha tocopherol transfer protein  Ttpa  tocopherol (alpha) transfer protein  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2012-07-05 LOC100909929  alpha-tocopherol transfer protein-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2003-04-09 Ttpa  tocopherol (alpha) transfer protein    Tocopherol transfer protein alpha  Name updated 629478 APPROVED
2002-06-10 Ttpa  Tocopherol transfer protein alpha      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_function binds alpha-Tocopherol 730016