Tsg101 (tumor susceptibility 101) - Rat Genome Database

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Gene: Tsg101 (tumor susceptibility 101) Rattus norvegicus
Analyze
Symbol: Tsg101
Name: tumor susceptibility 101
RGD ID: 3909
Description: Predicted to enable several functions, including protein homodimerization activity; ubiquitin protein ligase binding activity; and virion binding activity. Involved in endosome to lysosome transport; positive regulation of DNA-templated transcription; and positive regulation of protein monoubiquitination. Located in endosome membrane and nucleus. Human ortholog(s) of this gene implicated in breast cancer; breast carcinoma; cervix carcinoma; endometrial adenocarcinoma; and prostate cancer. Orthologous to human TSG101 (tumor susceptibility 101); PARTICIPATES IN autophagy pathway; endocytosis pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; benzo[a]pyrene; bisphenol A.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: ESCRT-I complex subunit TSG101; Rw; tumor supressor; Tumor supressor gene; tumor susceptibility gene 101
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81106,549,035 - 106,578,859 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1106,535,021 - 106,578,775 (-)EnsemblGRCr8
mRatBN7.2197,412,689 - 97,442,589 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl197,410,848 - 97,442,554 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1102,805,766 - 102,835,099 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01111,277,750 - 111,307,082 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01104,561,098 - 104,590,847 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01102,941,151 - 102,971,017 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1102,941,231 - 102,970,950 (-)Ensemblrn6Rnor6.0
Rnor_5.01104,015,969 - 104,044,641 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4197,445,040 - 97,475,141 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera191,659,356 - 91,689,173 (-)NCBICelera
RGSC_v3.1197,523,152 - 97,553,252 (-)NCBI
Cytogenetic Map1q22NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
centrosome  (IEA)
cytoplasm  (IDA,IEA,ISO,ISS)
cytosol  (IEA,ISO)
early endosome  (IEA,ISO)
early endosome membrane  (IEA)
endosome  (IDA,IEA,ISO)
endosome membrane  (IDA)
ESCRT I complex  (IBA,IEA,ISO,ISS)
extracellular exosome  (IEA,ISO)
Flemming body  (IEA)
late endosome  (IEA,ISO)
late endosome membrane  (IEA)
nucleus  (IDA,IEA)
plasma membrane  (IEA,ISO)
vesicle  (IEA)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. TSG101/mammalian VPS23 and mammalian VPS28 interact directly and are recruited to VPS4-induced endosomes. Bishop N and Woodman P, J Biol Chem. 2001 Apr 13;276(15):11735-42. Epub 2000 Dec 27.
2. TSG101 interacts with apoptosis-antagonizing transcription factor and enhances androgen receptor-mediated transcription by promoting its monoubiquitination. Burgdorf S, etal., J Biol Chem 2004 Apr 23;279(17):17524-34. Epub 2004 Feb 2.
3. Analysis of TSG101 tumour susceptibility gene transcripts in cervical and endometrial cancers. Chang JG, etal., Br J Cancer. 1999 Feb;79(3-4):445-50.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. Significant increase of a specific variant TSG101 transcript during the progression of cervical neoplasia. Klaes R, etal., Eur J Cancer. 1999 May;35(5):733-7.
6. Ubiquitylation of the gap junction protein connexin-43 signals its trafficking from early endosomes to lysosomes in a process mediated by Hrs and Tsg101. Leithe E, etal., J Cell Sci. 2009 Nov 1;122(Pt 21):3883-93. Epub 2009 Oct 6.
7. The TSG101 tumor susceptibility gene is located in chromosome 11 band p15 and is mutated in human breast cancer. Li L, etal., Cell. 1997 Jan 10;88(1):143-54.
8. Aberrant expression of TSG101 in Taiwan Chinese breast cancer. Lo YF, etal., Breast Cancer Res Treat. 2000 Apr;60(3):259-66.
9. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
10. Role of TSG101 in uterine cervix cancer. O'Boyle JD, etal., Gynecol Oncol. 1999 Dec;75(3):401-5.
11. Tsg101 is upregulated in a subset of invasive human breast cancers and its targeted overexpression in transgenic mice reveals weak oncogenic properties for mammary cancer initiation. Oh KB, etal., Oncogene. 2007 Aug 30;26(40):5950-9. Epub 2007 Mar 19.
12. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
13. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
14. GOA pipeline RGD automated data pipeline
15. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
16. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
17. How do ESCRT proteins control autophagy? Rusten TE and Stenmark H, J Cell Sci. 2009 Jul 1;122(Pt 13):2179-83.
18. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
19. Frequent abnormalities of TSG101 transcripts in human prostate cancer. Sun Z, etal., Oncogene. 1997 Dec 18;15(25):3121-5.
20. Stress-induced aberrant splicing of TSG101: association to high tumor grade and p53 status in breast cancers. Turpin E, etal., Oncogene. 1999 Dec 16;18(54):7834-7.
21. Up-regulation of tumor susceptibility gene 101 conveys poor prognosis through suppression of p21 expression in ovarian cancer. Young TW, etal., Clin Cancer Res. 2007 Jul 1;13(13):3848-54.
Additional References at PubMed
PMID:1300501   PMID:10888872   PMID:11595185   PMID:11916981   PMID:11943869   PMID:14519844   PMID:14556380   PMID:15126635   PMID:15218037   PMID:15256501   PMID:15326289   PMID:15489334  
PMID:15611048   PMID:16501490   PMID:16554368   PMID:16973552   PMID:17229889   PMID:17552904   PMID:17714434   PMID:17940959   PMID:18005716   PMID:18077552   PMID:18643869   PMID:19056867  
PMID:19520058   PMID:20654576   PMID:21757351   PMID:22232651   PMID:22315426   PMID:22660413   PMID:23092844   PMID:23376485   PMID:23533145   PMID:24105262   PMID:24205035   PMID:25392495  
PMID:30782301  


Genomics

Comparative Map Data
Tsg101
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81106,549,035 - 106,578,859 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1106,535,021 - 106,578,775 (-)EnsemblGRCr8
mRatBN7.2197,412,689 - 97,442,589 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl197,410,848 - 97,442,554 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1102,805,766 - 102,835,099 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01111,277,750 - 111,307,082 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01104,561,098 - 104,590,847 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01102,941,151 - 102,971,017 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1102,941,231 - 102,970,950 (-)Ensemblrn6Rnor6.0
Rnor_5.01104,015,969 - 104,044,641 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4197,445,040 - 97,475,141 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera191,659,356 - 91,689,173 (-)NCBICelera
RGSC_v3.1197,523,152 - 97,553,252 (-)NCBI
Cytogenetic Map1q22NCBI
TSG101
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381118,480,311 - 18,526,942 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1118,468,336 - 18,526,965 (-)Ensemblhg38GRCh38
GRCh371118,501,858 - 18,548,489 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361118,458,434 - 18,505,065 (-)NCBIBuild 36Build 36hg18NCBI36
Build 341118,458,435 - 18,505,065NCBI
Celera1118,637,463 - 18,684,120 (-)NCBICelera
Cytogenetic Map11p15.1NCBI
HuRef1118,187,557 - 18,234,372 (-)NCBIHuRef
CHM1_11118,501,223 - 18,547,842 (-)NCBICHM1_1
T2T-CHM13v2.01118,578,331 - 18,624,993 (-)NCBIT2T-CHM13v2.0
Tsg101
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39746,538,693 - 46,569,716 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl746,538,697 - 46,569,717 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38746,888,949 - 46,926,320 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl746,888,949 - 46,919,969 (-)Ensemblmm10GRCm38
MGSCv37754,144,397 - 54,175,300 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36746,757,396 - 46,787,915 (-)NCBIMGSCv36mm8
Celera742,369,255 - 42,400,171 (-)NCBICelera
Cytogenetic Map7B3NCBI
cM Map730.62NCBI
Tsg101
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541433,154,812 - 33,193,769 (-)Ensembl
ChiLan1.0NW_00495541433,154,812 - 33,193,769 (-)NCBIChiLan1.0ChiLan1.0
TSG101
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2920,797,111 - 20,843,855 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11120,757,432 - 20,804,234 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01118,518,110 - 18,564,814 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11118,201,381 - 18,248,149 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1118,189,868 - 18,248,149 (-)EnsemblpanPan2panpan1.1
TSG101
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12140,910,870 - 40,952,922 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2140,910,874 - 40,952,808 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha2140,390,143 - 40,432,212 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.02142,032,656 - 42,074,737 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2142,032,614 - 42,074,722 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12141,026,209 - 41,068,217 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02141,213,135 - 41,255,211 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02141,590,866 - 41,632,952 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
LOC101970059
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494744,718,596 - 44,726,328 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936528752,694 - 808,888 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_004936528752,572 - 809,127 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TSG101
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1240,673,187 - 40,720,681 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2243,759,512 - 43,783,691 (-)NCBISscrofa10.2Sscrofa10.2susScr3
TSG101
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1146,401,889 - 46,451,122 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl146,402,024 - 46,450,916 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_023666038143,746,335 - 143,804,463 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Tsg101
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247669,934,228 - 9,977,697 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247669,932,190 - 9,977,725 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Tsg101
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v12152,457,588 - 152,486,918 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Tsg101
320 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:53
Count of miRNA genes:49
Interacting mature miRNAs:52
Transcripts:ENSRNOT00000018194
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1582234Gluco18Glucose level QTL 183.40.0003blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)187889942132889942Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)151941022208479811Rat
1358359Sradr1Stress Responsive Adrenal Weight QTL 14.74adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)139728272132889942Rat
1331793Bp200Blood pressure QTL 2003.71601arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1102780511182384005Rat
1578654Bss10Bone structure and strength QTL 104femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)151940904168768703Rat
2300324Fetw1Fetal weight QTL 112.10.005fetal growth trait (VT:0004201)fetal body weight (CMO:0002080)192963855109494029Rat
1554320Bmd1Bone mineral density QTL 112.20.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)1101228864146228864Rat
1331800Scl25Serum cholesterol level QTL 253.013blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)187785026142582336Rat
7421628Bp361Blood pressure QTL 3610.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)183019780128019780Rat
631495Bp96Blood pressure QTL 964.52arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)166404680111404680Rat
70225Bp58Blood pressure QTL 583.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134184556172281316Rat
2298545Neuinf8Neuroinflammation QTL 84.6nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)166009857160501508Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134565911208798288Rat
631519Pia11Pristane induced arthritis QTL 115.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)193903998191260518Rat
1302788Scl19Serum cholesterol QTL 194.60.001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)166400974132889942Rat
1549903Bp267Blood pressure QTL 267arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)184107164115183752Rat
2313083Bmd74Bone mineral density QTL 7440.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)191302413136302413Rat
2313402Anxrr24Anxiety related response QTL 24aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)151511344153680016Rat
724567Tcas6Tongue tumor susceptibility QTL 66.85tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)1102359314153680016Rat
724521Uae1Urinary albumin excretion QTL 13.80.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)199645382182701046Rat
1358902Bw47Body weight QTL 471.67body mass (VT:0001259)body weight (CMO:0000012)199645382221502378Rat
1358192Ept13Estrogen-induced pituitary tumorigenesis QTL 133.4pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)186622262131622262Rat
2300164Bmd44Bone mineral density QTL 445.40.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)166077886111077886Rat
731168Bp154Blood pressure QTL 1543.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1103779152223964440Rat
631205Bp196Blood pressure QTL 19640.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)198879955208479939Rat
738022Anxrr13Anxiety related response QTL 134.60.00039locomotor behavior trait (VT:0001392)measurement of voluntary locomotion into, out of, or within a discrete space in an open field apparatus (CMO:0001514)192683681137683681Rat
10054135Gmadr2Adrenal mass QTL 21.970.0129adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)186993904131993904Rat
152025249Scl82Serum cholesterol level QTL 824.77blood cholesterol amount (VT:0000180)152891222109116986Rat
1331749Hrtrt11Heart rate QTL 112.973heart pumping trait (VT:2000009)heart rate (CMO:0000002)192683681137683681Rat
7411712Strs4Sensitivity to stroke QTL 48.7cerebrum integrity trait (VT:0010549)percentage of study population developing cerebrovascular lesions during a period of time (CMO:0000932)187558587132558587Rat
737977Bp160Blood pressure QTL 1600.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)197582336142582336Rat
2293142Bp314Blood pressure QTL 314arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1101594089146594089Rat
61433Cia2Collagen induced arthritis QTL 25joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1100345976145345976Rat
724529Cm16Cardiac mass QTL 162.7heart mass (VT:0007028)calculated heart weight (CMO:0000073)196717367160111531Rat

Markers in Region
D1Rat267  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2197,437,006 - 97,437,180 (+)MAPPERmRatBN7.2
Rnor_6.01102,965,445 - 102,965,617NCBIRnor6.0
Rnor_5.01104,039,136 - 104,039,308UniSTSRnor5.0
RGSC_v3.4197,469,635 - 97,469,808RGDRGSC3.4
RGSC_v3.4197,469,636 - 97,469,808UniSTSRGSC3.4
Celera191,683,670 - 91,683,840UniSTS
RGSC_v3.1197,547,746 - 97,547,919RGD
SHRSP x BN Map149.61RGD
SHRSP x BN Map149.61UniSTS
Cytogenetic Map1q22UniSTS
RH130601  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2197,415,035 - 97,415,219 (+)MAPPERmRatBN7.2
Rnor_6.01102,943,496 - 102,943,679NCBIRnor6.0
Rnor_5.01104,018,236 - 104,018,419UniSTSRnor5.0
RGSC_v3.4197,447,307 - 97,447,490UniSTSRGSC3.4
Celera191,661,623 - 91,661,806UniSTS
RH 3.4 Map1909.1UniSTS
Cytogenetic Map1q22UniSTS
AU047244  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2197,415,866 - 97,416,052 (+)MAPPERmRatBN7.2
Rnor_6.01102,944,326 - 102,944,511NCBIRnor6.0
Rnor_5.01104,019,066 - 104,019,251UniSTSRnor5.0
RGSC_v3.4197,448,137 - 97,448,322UniSTSRGSC3.4
Celera191,662,453 - 91,662,638UniSTS
Cytogenetic Map1q22UniSTS
AW140530  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2197,421,881 - 97,422,037 (+)MAPPERmRatBN7.2
Rnor_6.01102,950,340 - 102,950,495NCBIRnor6.0
Rnor_5.01104,025,080 - 104,025,235UniSTSRnor5.0
RGSC_v3.4197,454,151 - 97,454,306UniSTSRGSC3.4
Celera191,668,467 - 91,668,622UniSTS
RH 3.4 Map1909.1UniSTS
Cytogenetic Map1q22UniSTS
BI276330  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2197,412,802 - 97,412,956 (+)MAPPERmRatBN7.2
Rnor_6.01102,941,263 - 102,941,416NCBIRnor6.0
Rnor_5.01104,016,003 - 104,016,156UniSTSRnor5.0
RGSC_v3.4197,445,074 - 97,445,227UniSTSRGSC3.4
Celera191,659,390 - 91,659,543UniSTS
RH 3.4 Map1908.29UniSTS
Cytogenetic Map1q22UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000018194   ⟹   ENSRNOP00000018194
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1106,549,039 - 106,578,775 (-)Ensembl
mRatBN7.2 Ensembl197,412,765 - 97,442,508 (-)Ensembl
Rnor_6.0 Ensembl1102,941,231 - 102,970,950 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000097244   ⟹   ENSRNOP00000080249
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1106,549,039 - 106,570,353 (-)Ensembl
mRatBN7.2 Ensembl197,412,794 - 97,442,554 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000112656   ⟹   ENSRNOP00000080071
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1106,535,021 - 106,578,775 (-)Ensembl
mRatBN7.2 Ensembl197,410,848 - 97,442,502 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000148566   ⟹   ENSRNOP00000107951
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1106,549,039 - 106,571,846 (-)Ensembl
RefSeq Acc Id: NM_181628   ⟹   NP_853659
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81106,549,035 - 106,578,775 (-)NCBI
mRatBN7.2197,412,769 - 97,442,513 (-)NCBI
Rnor_6.01102,941,229 - 102,970,950 (-)NCBI
Rnor_5.01104,015,969 - 104,044,641 (-)NCBI
RGSC_v3.4197,445,040 - 97,475,141 (-)RGD
Celera191,659,356 - 91,689,173 (-)RGD
Sequence:
RefSeq Acc Id: XM_008759341   ⟹   XP_008757563
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81106,549,035 - 106,578,851 (-)NCBI
mRatBN7.2197,412,691 - 97,442,589 (-)NCBI
Rnor_6.01102,941,151 - 102,971,017 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039105117   ⟹   XP_038961045
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81106,549,035 - 106,571,633 (-)NCBI
mRatBN7.2197,412,689 - 97,442,568 (-)NCBI
RefSeq Acc Id: XM_039105126   ⟹   XP_038961054
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81106,549,035 - 106,569,252 (-)NCBI
mRatBN7.2197,412,691 - 97,442,568 (-)NCBI
RefSeq Acc Id: XM_063284274   ⟹   XP_063140344
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81106,549,035 - 106,578,859 (-)NCBI
RefSeq Acc Id: XM_063284275   ⟹   XP_063140345
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81106,549,035 - 106,567,536 (-)NCBI
RefSeq Acc Id: NP_853659   ⟸   NM_181628
- UniProtKB: Q7TSE5 (UniProtKB/Swiss-Prot),   Q6IRE4 (UniProtKB/Swiss-Prot),   A0A8I5ZSM6 (UniProtKB/TrEMBL),   A6JBD7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008757563   ⟸   XM_008759341
- Peptide Label: isoform X2
- UniProtKB: A0A8L2Q9C5 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000018194   ⟸   ENSRNOT00000018194
RefSeq Acc Id: XP_038961045   ⟸   XM_039105117
- Peptide Label: isoform X3
- UniProtKB: A0A8I5ZSM6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038961054   ⟸   XM_039105126
- Peptide Label: isoform X4
Ensembl Acc Id: ENSRNOP00000080249   ⟸   ENSRNOT00000097244
Ensembl Acc Id: ENSRNOP00000080071   ⟸   ENSRNOT00000112656
RefSeq Acc Id: XP_063140344   ⟸   XM_063284274
- Peptide Label: isoform X1
RefSeq Acc Id: XP_063140345   ⟸   XM_063284275
- Peptide Label: isoform X3
- UniProtKB: A0A8I5ZSM6 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000107951   ⟸   ENSRNOT00000148566
Protein Domains
SB   UEV

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q6IRE4-F1-model_v2 AlphaFold Q6IRE4 1-391 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13690070
Promoter ID:EPDNEW_R595
Type:initiation region
Name:Tsg101_1
Description:tumor susceptibility 101
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01102,970,983 - 102,971,043EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3909 AgrOrtholog
BioCyc Gene G2FUF-59602 BioCyc
Ensembl Genes ENSRNOG00000013381 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000018194 ENTREZGENE
  ENSRNOT00000112656.1 UniProtKB/Swiss-Prot
Gene3D-CATH 3.10.110.10 UniProtKB/Swiss-Prot
  6.10.140.820 UniProtKB/Swiss-Prot
  6.10.250.370 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7100763 IMAGE-MGC_LOAD
InterPro ESCRT-I_UEV_domain UniProtKB/Swiss-Prot
  ESCRT_assembly_dom UniProtKB/Swiss-Prot
  SB_dom UniProtKB/Swiss-Prot
  UBQ-conjugating_enzyme/RWD UniProtKB/Swiss-Prot
  UEV_N UniProtKB/Swiss-Prot
KEGG Report rno:292925 UniProtKB/Swiss-Prot
MGC_CLONE MGC:91392 IMAGE-MGC_LOAD
NCBI Gene Tsg101 ENTREZGENE
PANTHER TUMOR SUSCEPTIBILITY GENE 101 PROTEIN UniProtKB/Swiss-Prot
  TUMOR SUSCEPTIBILITY GENE 101 PROTEIN-RELATED UniProtKB/Swiss-Prot
Pfam UEV UniProtKB/Swiss-Prot
  Vps23_core UniProtKB/Swiss-Prot
PhenoGen Tsg101 PhenoGen
PROSITE PS51312 UniProtKB/Swiss-Prot
  UEV UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000013381 RatGTEx
SMART UBCc UniProtKB/Swiss-Prot
Superfamily-SCOP SSF140111 UniProtKB/Swiss-Prot
  SSF54495 UniProtKB/Swiss-Prot
UniProt A0A8I5ZSM6 ENTREZGENE, UniProtKB/TrEMBL
  A0A8L2Q9C5 ENTREZGENE, UniProtKB/TrEMBL
  A0ABK0LS70_RAT UniProtKB/TrEMBL
  A6JBD7 ENTREZGENE, UniProtKB/TrEMBL
  Q6IRE4 ENTREZGENE
  Q7TSE5 ENTREZGENE
  TS101_RAT UniProtKB/Swiss-Prot
UniProt Secondary Q7TSE5 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-09-17 Tsg101  tumor susceptibility 101  Tsg101  tumor susceptibility gene 101  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Tsg101  Tumor supressor gene      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_physical_interaction binds apoptosis-antagonizing transcription factor (AATF) 1300501