Tpi1 (triosephosphate isomerase 1) - Rat Genome Database

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Gene: Tpi1 (triosephosphate isomerase 1) Rattus norvegicus
Analyze
Symbol: Tpi1 (Ensembl: Tpi1l1)
Name: triosephosphate isomerase 1 (Ensembl:triosephosphate isomerase 1 like 1)
RGD ID: 3896
Description: Enables triose-phosphate isomerase activity. Predicted to be involved in several processes, including glucose metabolic process; glyceraldehyde-3-phosphate biosynthetic process; and methylglyoxal biosynthetic process. Predicted to act upstream of or within glucose metabolic process. Predicted to be located in cytoplasm. Predicted to be active in cytosol. Biomarker of ocular hypertension. Human ortholog(s) of this gene implicated in carbohydrate metabolic disorder and triosephosphate isomerase deficiency. Orthologous to human TPI1 (triosephosphate isomerase 1); PARTICIPATES IN Fanconi syndrome pathway; fructose and mannose metabolic pathway; fructose-1,6-bisphosphatase deficiency pathway; INTERACTS WITH (+)-schisandrin B; 1,2,4-trimethylbenzene; 1,3-dinitrobenzene.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: LOC100911515; methylglyoxal synthase; MGC156639; TIM; Tpi; triose-phosphate isomerase; triosephosphate isomerase; triosephosphate isomerase-like
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Related Pseudogenes: LOC681129  
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84159,301,558 - 159,305,088 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl4159,301,562 - 159,305,413 (-)EnsemblGRCr8
mRatBN7.24157,615,283 - 157,618,813 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4157,615,386 - 157,619,541 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx4163,843,450 - 163,846,958 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04159,626,360 - 159,629,868 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04158,261,966 - 158,265,490 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.04157,328,375 - 157,331,905 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_5.04224,345,971 - 224,349,501 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.44160,933,341 - 160,936,871 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera4146,353,273 - 146,356,791 (-)NCBICelera
RGSC_v3.14161,178,382 - 161,181,807 (-)NCBI
Cytogenetic Map4q42NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
1,2,4-trimethylbenzene  (EXP)
1,2-dimethylhydrazine  (ISO)
1,3-dinitrobenzene  (EXP)
1-bromopropane  (EXP)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (EXP,ISO)
2,4-dinitrotoluene  (EXP)
2,5-hexanedione  (EXP)
2,6-dimethoxyphenol  (ISO)
3-chloropropane-1,2-diol  (EXP)
4,4'-sulfonyldiphenol  (EXP,ISO)
4-hydroxynon-2-enal  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (EXP)
acrolein  (ISO)
acrylamide  (EXP)
all-trans-retinoic acid  (ISO)
all-trans-retinol  (EXP)
alpha-naphthoflavone  (ISO)
alpha-pinene  (ISO)
alpha-Zearalanol  (EXP)
ammonium chloride  (EXP)
amphetamine  (EXP)
aristolochic acid A  (ISO)
arsane  (EXP)
arsenic atom  (EXP)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
Azaspiracid  (ISO)
benzalkonium chloride  (ISO)
benzo[a]pyrene  (ISO)
bis(2-chloroethyl) sulfide  (EXP)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
bisphenol F  (EXP,ISO)
bortezomib  (ISO)
bromobenzene  (EXP)
bucladesine  (ISO)
bufalin  (ISO)
Butylbenzyl phthalate  (EXP,ISO)
cadmium acetate  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
caffeine  (ISO)
capsaicin  (ISO)
captan  (ISO)
carbamazepine  (ISO)
carbon dioxide  (EXP)
carbon nanotube  (ISO)
casticin  (ISO)
ceruletide  (EXP)
chloropicrin  (ISO)
chlorpyrifos  (ISO)
cisplatin  (ISO)
clobetasol  (ISO)
clofibrate  (EXP)
clozapine  (EXP)
cobalt dichloride  (EXP)
copper(II) sulfate  (ISO)
coumestrol  (ISO)
cyclosporin A  (ISO)
deguelin  (ISO)
desferrioxamine B  (EXP)
dexamethasone  (ISO)
dextran sulfate  (ISO)
diarsenic trioxide  (ISO)
dibutyl phthalate  (EXP,ISO)
diethyl phthalate  (ISO)
dihydroartemisinin  (ISO)
dihydroxyacetone  (EXP)
dihydroxyacetone phosphate  (EXP)
diisobutyl phthalate  (ISO)
diisononyl phthalate  (ISO)
dinophysistoxin 1  (ISO)
dioxygen  (ISO)
dipotassium bis[mu-tartrato(4-)]diantimonate(2-) trihydrate  (ISO)
dizocilpine maleate  (EXP)
dorsomorphin  (ISO)
doxorubicin  (ISO)
elemental selenium  (ISO)
Enterolactone  (ISO)
enzyme inhibitor  (ISO)
ethanol  (EXP,ISO)
etoposide  (ISO)
fenthion  (ISO)
flutamide  (EXP)
folic acid  (ISO)
folpet  (ISO)
FR900359  (ISO)
furan  (EXP)
furfural  (ISO)
genistein  (EXP)
haloperidol  (EXP)
hydralazine  (ISO)
ibuprofen  (ISO)
indometacin  (EXP)
ivermectin  (ISO)
lithium atom  (EXP)
lithium hydride  (EXP)
mancozeb  (ISO)
medroxyprogesterone acetate  (ISO)
methamphetamine  (EXP)
methidathion  (ISO)
methimazole  (EXP)
methotrexate  (ISO)
methylisothiazolinone  (ISO)
methylmercury chloride  (ISO)
microcystin-LR  (EXP)
N-methyl-4-phenylpyridinium  (ISO)
N-nitrosodiethylamine  (ISO)
nickel dichloride  (EXP,ISO)
nickel subsulfide  (EXP,ISO)
niclosamide  (ISO)
nimesulide  (EXP)
nitrates  (ISO)
okadaic acid  (ISO)
olomoucine  (ISO)
ouabain  (ISO)
ozone  (EXP,ISO)
p-menthan-3-ol  (ISO)
p-toluidine  (EXP)
paracetamol  (EXP,ISO)
paraquat  (EXP)
perfluorooctanoic acid  (EXP)
Pf-06840003  (ISO)
phenylpropanolamine  (ISO)
pioglitazone  (ISO)
pirinixic acid  (EXP)
pregnenolone 16alpha-carbonitrile  (EXP)
quartz  (ISO)
quercetin  (ISO)
resveratrol  (ISO)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (EXP)
sarin  (EXP)
SB 431542  (ISO)
selenium atom  (ISO)
silicon dioxide  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sodium chloride  (ISO)
sodium dichromate  (ISO)
sodium fluoride  (ISO)
T-2 toxin  (EXP)
tamoxifen  (ISO)
tetrachloromethane  (EXP,ISO)
thapsigargin  (ISO)
thifluzamide  (ISO)
thimerosal  (ISO)
thiram  (ISO)
toosendanin  (EXP)
trichloroethene  (EXP)
trimellitic anhydride  (ISO)
triphenyl phosphate  (ISO)
trovafloxacin  (EXP)
tunicamycin  (ISO)
undecane  (EXP)
valproic acid  (ISO)
vincristine  (ISO)
vitamin E  (ISO)
vorinostat  (ISO)
Yessotoxin  (ISO)
zearalenone  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IEA)
cytosol  (IBA,ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Evidence for founder effect of the Glu104Asp substitution and identification of new mutations in triosephosphate isomerase deficiency. Arya R, etal., Hum Mutat. 1997;10(4):290-4.
2. Key enzymes of carbohydrate metabolism as targets of the 11.5-kDa Zn(2+)-binding protein (parathymosin). Brand IA and Heinickel A, J Biol Chem. 1991 Nov 5;266(31):20984-9.
3. The glycolytic enzymes, glyceraldehyde-3-phosphate dehydrogenase, triose-phosphate isomerase, and pyruvate kinase are components of the K(ATP) channel macromolecular complex and regulate its function. Dhar-Chowdhury P, etal., J Biol Chem. 2005 Nov 18;280(46):38464-70. Epub 2005 Sep 16.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
6. Differences in expression of retinal proteins between diabetic and normal rats. Liu SQ, etal., World J Gastroenterol. 2007 Apr 14;13(14):2118-24.
7. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
8. Proteomic analysis of rat retina in a steroid-induced ocular hypertension model: potential vulnerability to oxidative stress. Miyara N, etal., Jpn J Ophthalmol. 2008 Mar-Apr;52(2):84-90. Epub 2008 Apr 30.
9. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
10. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
11. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
12. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
13. GOA pipeline RGD automated data pipeline
14. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
15. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
16. Information Derived from GenBank Report RGD, Sept. 2003
17. Proteomics profiling of nuclear proteins for kidney fibroblasts suggests hypoxia, meiosis, and cancer may meet in the nucleus. Shakib K, etal., Proteomics. 2005 Jul;5(11):2819-38.
18. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
Additional References at PubMed
PMID:204065   PMID:566475   PMID:566476   PMID:2693209   PMID:3796661   PMID:6434534   PMID:8417789   PMID:15155459   PMID:15489334   PMID:15632090   PMID:16502470   PMID:16854843  
PMID:17023274   PMID:18562316   PMID:19056867   PMID:19182904   PMID:19725078   PMID:21630459   PMID:22420779   PMID:22664934   PMID:22871113   PMID:23376485   PMID:23533145   PMID:23580065  
PMID:26316108   PMID:26945066   PMID:28131823   PMID:29476059   PMID:33450132   PMID:35111160   PMID:35352799   PMID:36755387  


Genomics

Comparative Map Data
Tpi1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84159,301,558 - 159,305,088 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl4159,301,562 - 159,305,413 (-)EnsemblGRCr8
mRatBN7.24157,615,283 - 157,618,813 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4157,615,386 - 157,619,541 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx4163,843,450 - 163,846,958 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04159,626,360 - 159,629,868 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04158,261,966 - 158,265,490 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.04157,328,375 - 157,331,905 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_5.04224,345,971 - 224,349,501 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.44160,933,341 - 160,936,871 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera4146,353,273 - 146,356,791 (-)NCBICelera
RGSC_v3.14161,178,382 - 161,181,807 (-)NCBI
Cytogenetic Map4q42NCBI
TPI1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38126,867,420 - 6,870,948 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl126,867,119 - 6,870,948 (+)Ensemblhg38GRCh38
GRCh37126,976,584 - 6,980,112 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36126,846,967 - 6,850,253 (+)NCBIBuild 36Build 36hg18NCBI36
Build 34126,846,966 - 6,850,253NCBI
Celera128,593,870 - 8,597,397 (+)NCBICelera
Cytogenetic Map12p13.31NCBI
HuRef126,830,312 - 6,833,839 (+)NCBIHuRef
CHM1_1126,975,582 - 6,979,109 (+)NCBICHM1_1
T2T-CHM13v2.0126,876,717 - 6,880,246 (+)NCBIT2T-CHM13v2.0
Tpi1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm396124,787,549 - 124,791,121 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl6124,787,549 - 124,791,259 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm386124,810,586 - 124,814,158 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl6124,810,586 - 124,814,296 (-)Ensemblmm10GRCm38
MGSCv376124,760,610 - 124,764,314 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv366124,776,334 - 124,780,031 (-)NCBIMGSCv36mm8
Celera6126,486,721 - 126,490,425 (-)NCBICelera
Cytogenetic Map6F2NCBI
cM Map659.17NCBI
Tpi1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554134,467,566 - 4,471,177 (+)Ensembl
ChiLan1.0NW_0049554134,467,615 - 4,471,594 (+)NCBIChiLan1.0ChiLan1.0
TPI1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21012,430,570 - 12,434,002 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11212,427,328 - 12,430,760 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0126,999,275 - 7,002,678 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1126,910,819 - 6,914,056 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl126,910,813 - 6,913,612 (+)EnsemblpanPan2panpan1.1
TPI1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12738,154,519 - 38,157,900 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2738,154,519 - 38,158,137 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha278,458,847 - 8,462,228 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.02738,507,407 - 38,510,797 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2738,507,407 - 38,510,859 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12738,381,481 - 38,384,861 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02738,422,508 - 38,425,888 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0277,937,580 - 7,940,961 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Tpi1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404945102,280,602 - 102,283,888 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936709945,201 - 951,441 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_004936709948,151 - 951,430 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TPI1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl563,838,506 - 63,843,134 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1563,839,473 - 63,842,853 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2566,274,980 - 66,278,361 (-)NCBISscrofa10.2Sscrofa10.2susScr3
TPI1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1116,900,762 - 6,904,188 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl116,900,787 - 6,906,787 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_0236660631,319,371 - 1,323,379 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Tpi1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248603,533,320 - 3,539,755 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046248603,533,226 - 3,536,786 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Tpi1
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1623,077,982 - 23,081,492 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Tpi1
24 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:135
Count of miRNA genes:107
Interacting mature miRNAs:114
Transcripts:ENSRNOT00000020647
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
6478754Anxrr43Anxiety related response QTL 430.14035locomotor behavior trait (VT:0001392)distance moved per unit of time into, out of or within a discrete space in an experimental apparatus (CMO:0001493)4146370897184426481Rat
724558Plsm2Polydactyly-luxate syndrome (PLS) morphotypes QTL 20.0003hindlimb integrity trait (VT:0010563)hind foot phalanges count (CMO:0001949)4134095016179095016Rat
1582237Kidm34Kidney mass QTL 3440.0001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)4149763204169799698Rat
6478693Anxrr32Anxiety related response QTL 320.00092locomotor behavior trait (VT:0001392)measurement of voluntary locomotion into, out of or within a discrete space in an experimental apparatus (CMO:0000957)4146370897184426481Rat
6478757Anxrr44Anxiety related response QTL 440.01087locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4155834926184426481Rat
1358364Sradr4Stress Responsive Adrenal Weight QTL 44.92adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)4131384565176384565Rat
10755501Bp390Blood pressure QTL 3902.5arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)427730518170099664Rat
61451Ciaa4CIA Autoantibody QTL 43.1blood autoantibody amount (VT:0003725)calculated serum anti-rat type 2 collagen autoantibody titer (CMO:0001281)4123870974168870974Rat
1331802Srn5Serum renin concentration QTL 53.045renin activity (VT:0005581)plasma renin activity level (CMO:0000116)4117559384162559384Rat
1331738Bp209Blood pressure QTL 2092.979arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)4140059299181024663Rat
6478700Anxrr33Anxiety related response QTL 330.00896locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4146370897184426481Rat
1298524Oia8Oil induced arthritis QTL 8joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4140059299184426481Rat
10053718Scort25Serum corticosterone level QTL 252.150.0097blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)4157292416184426481Rat
738009Sach4Saccharine consumption QTL 44.90.000016consumption behavior trait (VT:0002069)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)460916264184426481Rat
634335Anxrr16Anxiety related response QTL 167.22locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)494638356168870820Rat
737821Hcar9Hepatocarcinoma resistance QTL 93.7liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)4106848959168870974Rat
7411558Bw133Body weight QTL 13313.840.001body mass (VT:0001259)body weight gain (CMO:0000420)4127263297172263297Rat
6478778Anxrr51Anxiety related response QTL 510.25384locomotor behavior trait (VT:0001392)measurement of voluntary locomotion into, out of or within a discrete space in an experimental apparatus (CMO:0000957)4126334185171334185Rat
10401796Kidm48Kidney mass QTL 48kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)4147299608184426481Rat
6478718Anxrr34Anxiety related response QTL 340.00896locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4146370897184426481Rat
6478782Anxrr52Anxiety related response QTL 520.02091locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4155834926184426481Rat
631511Pia7Pristane induced arthritis QTL 74.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4123870974168870974Rat
634347Hcar8Hepatocarcinoma resistance QTL 85.8liver integrity trait (VT:0010547)liver tumorous lesion area to total liver area ratio (CMO:0001075)4124700988169700988Rat
6478720Alc23Alcohol consumption QTL 230.00509drinking behavior trait (VT:0001422)ethanol drink intake rate to body weight ratio (CMO:0001616)4155834926184426481Rat
6478785Anxrr53Anxiety related response QTL 530.01397locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4155834926184426481Rat
738031Alc14Alcohol consumption QTL 147.60.00003consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)460916264174095838Rat
1576316Ept5Estrogen-induced pituitary tumorigenesis QTL 53.8pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)4100752691179366077Rat
1581566Eae21Experimental allergic encephalomyelitis QTL 216.2body mass (VT:0001259)maximum body weight loss to initial body weight ratio (CMO:0001400)4137447185182447185Rat
1578674Bmd12Bone mineral density QTL 123.8femur mineral mass (VT:0010011)compact volumetric bone mineral density (CMO:0001730)4137430611182430611Rat
6478728Anxrr36Anxiety related response QTL 360.01061locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4155834926184426481Rat
738016Alc16Alcohol consumption QTL 163.60.00015consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)460916264184426481Rat
1358202Gluco11Glucose level QTL 112.40.02adipocyte glucose uptake trait (VT:0004185)absolute change in adipocyte glucose uptake (CMO:0000873)486709649168870974Rat
61422Cia13Collagen induced arthritis QTL 134.5joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4134199006168870974Rat
634342Cia24Collagen induced arthritis QTL 244.5joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4148121375176967367Rat
6478733Anxrr37Anxiety related response QTL 370.00095locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4155834926184426481Rat
737978Pia23Pristane induced arthritis QTL 235.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4123870974168870974Rat
61362Oia2Oil induced arthritis QTL 20.001joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4140059299184426481Rat
6478737Anxrr38Anxiety related response QTL 380.00159locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4155834926184426481Rat
12798519Anxrr54Anxiety related response QTL 542.540.05locomotor behavior trait (VT:0001392)distance moved per unit of time into, out of or within a discrete space in an experimental apparatus (CMO:0001493)4116184844161184844Rat
2316958Gluco58Glucose level QTL 5810blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)412212457182430611Rat
6478748Anxrr42Anxiety related response QTL 420.28008locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4146370897184426481Rat
12798525Anxrr57Anxiety related response QTL 573.210.05locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4148834094168870974Rat

Markers in Region
RH94523  
Rat AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map4q42UniSTS
RH129184  
Rat AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map4q42UniSTS
AI411387  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.24157,619,843 - 157,620,056 (-)MAPPERmRatBN7.2
mRatBN7.24157,619,843 - 157,620,056 (+)MAPPERmRatBN7.2
Rnor_6.04157,332,936 - 157,333,148NCBIRnor6.0
Rnor_6.0920,212,509 - 20,212,721NCBIRnor6.0
Rnor_5.04224,350,532 - 224,350,744UniSTSRnor5.0
Rnor_5.0919,088,485 - 19,088,697UniSTSRnor5.0
RGSC_v3.44160,937,902 - 160,938,114UniSTSRGSC3.4
Celera4146,357,822 - 146,358,034UniSTS
RH 3.4 Map41005.8UniSTS
Cytogenetic Map4q42UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
25 23 116 273 173 174 113 113 113 12 561 281 11 236 126 147 61 17 17

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_022922 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC115420 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC061781 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC126087 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473964 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ212675 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ214607 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ214670 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ214759 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ214880 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ215018 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ215213 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ215529 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ215606 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ215810 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ215834 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ215973 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ216226 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ216307 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ216332 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ216584 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ216804 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ223237 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ224880 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ224920 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ224970 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000004 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  L36250 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000020647   ⟹   ENSRNOP00000020647
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl4159,301,562 - 159,305,413 (-)Ensembl
mRatBN7.2 Ensembl4157,615,386 - 157,619,050 (-)Ensembl
Rnor_6.0 Ensembl4157,328,379 - 157,331,905 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000071439   ⟹   ENSRNOP00000067409
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl4159,301,562 - 159,305,088 (-)Ensembl
mRatBN7.2 Ensembl4157,615,386 - 157,618,825 (-)Ensembl
Rnor_6.0 Ensembl920,213,776 - 20,216,608 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000089341   ⟹   ENSRNOP00000069904
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl920,213,588 - 20,217,176 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000117284   ⟹   ENSRNOP00000088185
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl4157,615,386 - 157,619,541 (-)Ensembl
RefSeq Acc Id: NM_022922   ⟹   NP_075211
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84159,301,558 - 159,305,088 (-)NCBI
mRatBN7.24157,615,283 - 157,618,813 (-)NCBI
Rnor_6.04157,328,375 - 157,331,905 (-)NCBI
Rnor_5.04224,345,971 - 224,349,501 (-)NCBI
RGSC_v3.44160,933,341 - 160,936,871 (-)RGD
Celera4146,353,273 - 146,356,791 (-)RGD
Sequence:
RefSeq Acc Id: NP_075211   ⟸   NM_022922
- UniProtKB: A0JN18 (UniProtKB/Swiss-Prot),   Q6P793 (UniProtKB/Swiss-Prot),   P48500 (UniProtKB/Swiss-Prot),   Q6SA19 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000020647   ⟸   ENSRNOT00000020647
Ensembl Acc Id: ENSRNOP00000067409   ⟸   ENSRNOT00000071439
Ensembl Acc Id: ENSRNOP00000069904   ⟸   ENSRNOT00000089341
Ensembl Acc Id: ENSRNOP00000088185   ⟸   ENSRNOT00000117284

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P48500-F1-model_v2 AlphaFold P48500 1-249 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13693390
Promoter ID:EPDNEW_R3915
Type:multiple initiation site
Name:Tpi1_1
Description:triosephosphate isomerase 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.04157,331,917 - 157,331,977EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3896 AgrOrtholog
BioCyc Gene G2FUF-43066 BioCyc
BioCyc Pathway ANAGLYCOLYSIS-PWY [glycolysis III (from glucose)] BioCyc
  PWY66-373 [sucrose degradation V (sucrose alpha-glucosidase)] BioCyc
  PWY66-399 [gluconeogenesis III] BioCyc
BioCyc Pathway Image ANAGLYCOLYSIS-PWY BioCyc
  PWY66-373 BioCyc
  PWY66-399 BioCyc
Ensembl Genes ENSRNOG00000015290 Ensembl, ENTREZGENE
  ENSRNOG00000050669 Ensembl
Ensembl Transcript ENSRNOT00000020647 ENTREZGENE
Gene3D-CATH 3.20.20.70 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:5623367 IMAGE-MGC_LOAD
  IMAGE:8368624 IMAGE-MGC_LOAD
InterPro Aldolase_TIM UniProtKB/Swiss-Prot
  TIM_sf UniProtKB/Swiss-Prot
  TrioseP_Isoase_bac/euk UniProtKB/Swiss-Prot
  Triosephosphate_isomerase UniProtKB/Swiss-Prot
  Triosephosphate_isomerase_AS UniProtKB/Swiss-Prot
KEGG Report rno:24849 UniProtKB/Swiss-Prot
MGC_CLONE MGC:156639 IMAGE-MGC_LOAD
  MGC:72436 IMAGE-MGC_LOAD
NCBI Gene 24849 ENTREZGENE
PANTHER PTHR21139 UniProtKB/Swiss-Prot
  TRIOSEPHOSPHATE ISOMERASE UniProtKB/Swiss-Prot
Pfam TIM UniProtKB/Swiss-Prot
PhenoGen Tpi1 PhenoGen
PROSITE TIM_1 UniProtKB/Swiss-Prot
  TIM_2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000015290 RatGTEx
  ENSRNOG00000050669 RatGTEx
Superfamily-SCOP SSF51351 UniProtKB/Swiss-Prot
UniProt A0A8L2QAQ2_RAT UniProtKB/TrEMBL
  A0A8L2R053_RAT UniProtKB/TrEMBL
  A0JN18 ENTREZGENE
  P48500 ENTREZGENE
  Q6P793 ENTREZGENE
  Q6SA19 ENTREZGENE
  TPIS_RAT UniProtKB/Swiss-Prot
UniProt Secondary A0JN18 UniProtKB/Swiss-Prot
  Q6P793 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-03-09 Tpi1  triosephosphate isomerase 1  LOC100911515  triosephosphate isomerase-like  Data merged from RGD:6492323 737654 PROVISIONAL
2012-07-05 LOC100911515  triosephosphate isomerase-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2003-04-09 Tpi1  triosephosphate isomerase 1    Triosephosphate isomerase 1  Name updated 629478 APPROVED
2002-06-10 Tpi1  Triosephosphate isomerase 1      Symbol and Name status set to approved 70586 APPROVED