Pvr (PVR cell adhesion molecule) - Rat Genome Database

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Gene: Pvr (PVR cell adhesion molecule) Rattus norvegicus
Analyze
Symbol: Pvr
Name: PVR cell adhesion molecule
RGD ID: 3813
Description: Enables virus receptor activity. Predicted to be involved in several processes, including heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules; homophilic cell adhesion via plasma membrane adhesion molecules; and positive regulation of leukocyte mediated cytotoxicity. Predicted to act upstream of or within cell migration; cell-cell adhesion; and negative regulation of natural killer cell mediated cytotoxicity. Predicted to be located in cell surface and membrane. Predicted to be active in adherens junction and plasma membrane. Orthologous to human PVR (PVR cell adhesion molecule); INTERACTS WITH (+)-schisandrin B; 1-naphthyl isothiocyanate; 17alpha-ethynylestradiol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: poliovirus receptor; Taa1; Tage4; tumor-associated antigen 1; tumor-associated glycoprotein E4; tumor-associated glycoprotein pE4
RGD Orthologs
Human
Mouse
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8188,689,235 - 88,704,641 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl188,688,981 - 88,704,630 (-)EnsemblGRCr8
mRatBN7.2179,561,294 - 79,576,700 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl179,546,879 - 79,576,715 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx184,955,696 - 84,971,120 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0193,505,836 - 93,521,203 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0186,710,813 - 86,726,237 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0180,820,306 - 80,835,712 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl180,820,050 - 80,835,701 (-)Ensemblrn6Rnor6.0
Rnor_5.0182,085,555 - 82,100,961 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4179,213,654 - 79,229,063 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera174,018,461 - 74,033,867 (-)NCBICelera
RGSC_v3.1179,291,499 - 79,307,163 (-)NCBI
RH 3.4 Map1819.8RGD
Cytogenetic Map1q21NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(1->4)-beta-D-glucan  (ISO)
1,2,4-trichloro-5-(2,5-dichlorophenyl)benzene  (ISO)
1,2-dimethylhydrazine  (ISO)
1-naphthyl isothiocyanate  (EXP)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,4'-trichlorobiphenyl  (ISO)
2,4-diaminotoluene  (ISO)
2,4-dinitrotoluene  (EXP)
2,6-dinitrotoluene  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3,3',5,5'-tetrabromobisphenol A  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-amino-2,6-dinitrotoluene  (EXP)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
acrylamide  (EXP)
aflatoxin B1  (EXP)
aldehydo-D-glucose  (ISO)
amitrole  (EXP)
ammonium chloride  (EXP)
antirheumatic drug  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
atrazine  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
Bisphenol B  (ISO)
bromobenzene  (EXP)
cadmium dichloride  (EXP,ISO)
carbofuran  (EXP)
carbon nanotube  (ISO)
cefaloridine  (EXP)
chloroform  (EXP)
cisplatin  (ISO)
Cuprizon  (EXP)
cyclosporin A  (ISO)
cyproconazole  (EXP)
D-glucose  (ISO)
deoxynivalenol  (ISO)
dibutyl phthalate  (EXP)
dicrotophos  (ISO)
dioxygen  (EXP,ISO)
doxorubicin  (EXP,ISO)
endosulfan  (EXP)
fluoranthene  (ISO)
folic acid  (ISO)
formaldehyde  (EXP)
furan  (EXP)
gentamycin  (EXP)
glucose  (ISO)
glycidol  (EXP)
gold atom  (ISO)
gold(0)  (ISO)
graphite  (EXP)
GW 7647  (ISO)
indole-3-methanol  (EXP)
isoprenaline  (EXP)
ivermectin  (ISO)
lead(0)  (ISO)
leflunomide  (ISO)
lidocaine  (EXP)
lipopolysaccharide  (EXP,ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
mercury dichloride  (EXP)
methamphetamine  (EXP)
methapyrilene  (EXP)
methimazole  (EXP)
methoxychlor  (EXP)
N1'-[2-[[5-[(dimethylamino)methyl]-2-furanyl]methylthio]ethyl]-N1-methyl-2-nitroethene-1,1-diamine  (EXP)
nickel atom  (ISO)
nickel dichloride  (EXP)
orphenadrine  (EXP)
oxaliplatin  (EXP)
ozone  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP)
PCB138  (ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP,ISO)
phenobarbital  (EXP)
phenylephrine  (EXP)
pirinixic acid  (EXP,ISO)
propiconazole  (ISO)
ranitidine  (EXP)
rotenone  (EXP,ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
silicon dioxide  (ISO)
Soman  (EXP)
sulfadimethoxine  (EXP)
tert-butyl hydroperoxide  (ISO)
tetrachloromethane  (EXP,ISO)
tetracycline  (EXP)
thioacetamide  (EXP)
topotecan  (EXP)
torcetrapib  (ISO)
triadimefon  (EXP)
trichloroethene  (EXP)
triptonide  (ISO)
valproic acid  (ISO)
vancomycin  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cell surface  (ISO)
membrane  (IEA,ISO)
plasma membrane  (ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Organization of the rat Tage4 gene and herpesvirus entry activity of the encoded protein. Baury B, etal., Gene 2001 Mar 7;265(1-2):185-94.
2. A novel member of the immunoglobulin gene superfamily expressed in rat carcinoma cell lines. Chadeneau C, etal., J Biol Chem 1994 Jun 3;269(22):15601-5.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
5. High-density rat radiation hybrid maps containing over 24,000 SSLPs, genes, and ESTs provide a direct link to the rat genome sequence. Kwitek AE, etal., Genome Res. 2004 Apr;14(4):750-7
6. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
7. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
8. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
9. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:11751937   PMID:12477932   PMID:12740392   PMID:12913096   PMID:15039383   PMID:16304049   PMID:16440345   PMID:16831868   PMID:20680398   PMID:21423176   PMID:22027834   PMID:23376485  
PMID:27733379  


Genomics

Comparative Map Data
Pvr
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8188,689,235 - 88,704,641 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl188,688,981 - 88,704,630 (-)EnsemblGRCr8
mRatBN7.2179,561,294 - 79,576,700 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl179,546,879 - 79,576,715 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx184,955,696 - 84,971,120 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0193,505,836 - 93,521,203 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0186,710,813 - 86,726,237 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0180,820,306 - 80,835,712 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl180,820,050 - 80,835,701 (-)Ensemblrn6Rnor6.0
Rnor_5.0182,085,555 - 82,100,961 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4179,213,654 - 79,229,063 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera174,018,461 - 74,033,867 (-)NCBICelera
RGSC_v3.1179,291,499 - 79,307,163 (-)NCBI
RH 3.4 Map1819.8RGD
Cytogenetic Map1q21NCBI
PVR
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381944,643,910 - 44,666,162 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1944,643,798 - 44,666,162 (+)Ensemblhg38GRCh38
GRCh371945,147,210 - 45,169,430 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361949,839,066 - 49,858,690 (+)NCBIBuild 36Build 36hg18NCBI36
Build 341949,839,065 - 49,858,689NCBI
Celera1941,951,144 - 41,973,471 (+)NCBICelera
Cytogenetic Map19q13.31NCBI
HuRef1941,579,341 - 41,601,754 (+)NCBIHuRef
CHM1_11945,149,748 - 45,172,111 (+)NCBICHM1_1
T2T-CHM13v2.01947,468,632 - 47,490,944 (+)NCBIT2T-CHM13v2.0
Pvr
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39719,637,503 - 19,655,068 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl719,637,503 - 19,655,085 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38719,903,578 - 19,921,143 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl719,903,578 - 19,921,160 (-)Ensemblmm10GRCm38
MGSCv37720,488,927 - 20,506,492 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36719,062,100 - 19,079,613 (-)NCBIMGSCv36mm8
Celera717,310,717 - 17,327,912 (-)NCBICelera
Cytogenetic Map7A3NCBI
cM Map79.95NCBI
PVR
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22050,803,497 - 50,823,257 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11952,675,478 - 52,695,282 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01941,592,042 - 41,614,397 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11950,196,980 - 50,216,832 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1950,196,980 - 50,217,006 (+)EnsemblpanPan2panpan1.1
PVR
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11110,692,906 - 110,713,209 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1110,697,911 - 110,754,296 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1110,175,812 - 110,196,115 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01111,257,096 - 111,277,399 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1111,261,295 - 111,277,390 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11110,898,742 - 110,919,041 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01110,534,429 - 110,554,736 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01111,404,145 - 111,424,445 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Pvr
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934917,009,613 - 17,022,236 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049367061,357,041 - 1,370,442 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049367061,356,690 - 1,369,547 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PVR
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1651,161,320 - 51,178,464 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2647,020,048 - 47,038,024 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PVR
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1638,127,864 - 38,141,612 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_023667612773 - 12,781 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0

Variants

.
Variants in Pvr
76 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:253
Count of miRNA genes:82
Interacting mature miRNAs:98
Transcripts:ENSRNOT00000043096, ENSRNOT00000064305
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1578649Bmd8Bone mineral density QTL 84.9femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)151940904101229020Rat
1582234Gluco18Glucose level QTL 183.40.0003blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)187889942132889942Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)151941022208479811Rat
1358359Sradr1Stress Responsive Adrenal Weight QTL 14.74adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)139728272132889942Rat
4889929Bss87Bone structure and strength QTL 876.7tibia area (VT:1000281)tibia-fibula cortical bone endosteal cross-sectional area (CMO:0001722)14630261591302615Rat
2313062Bmd73Bone mineral density QTL 733.90.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)14630261591302615Rat
1578654Bss10Bone structure and strength QTL 104femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)151940904168768703Rat
2313065Bss67Bone structure and strength QTL 673.10.0001tibia area (VT:1000281)tibia total energy absorbed before break (CMO:0001736)14630261591302615Rat
1331800Scl25Serum cholesterol level QTL 253.013blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)187785026142582336Rat
7421628Bp361Blood pressure QTL 3610.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)183019780128019780Rat
631495Bp96Blood pressure QTL 964.52arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)166404680111404680Rat
2313069Bss68Bone structure and strength QTL 682.90.0001tibia size trait (VT:0100001)tibia total energy absorbed before break (CMO:0001736)14630261591302615Rat
70225Bp58Blood pressure QTL 583.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134184556172281316Rat
2313075Bss66Bone structure and strength QTL 663.40.0001tibia length (VT:0004357)tibia length (CMO:0000450)14630261591302615Rat
631512Scl6Serum cholesterol level QTL 69.6blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)18126986099645535Rat
2298545Neuinf8Neuroinflammation QTL 84.6nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)166009857160501508Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134565911208798288Rat
2313077Bss69Bone structure and strength QTL 693.50.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)14630261591302615Rat
1302788Scl19Serum cholesterol QTL 194.60.001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)166400974132889942Rat
1549903Bp267Blood pressure QTL 267arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)184107164115183752Rat
2313402Anxrr24Anxiety related response QTL 24aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)151511344153680016Rat
61342Bp27Blood pressure QTL 273.40.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)16540563796805205Rat
4889962Bss94Bone structure and strength QTL 943.8tibia area (VT:1000281)tibia-fibula cortical bone endosteal cross-sectional area (CMO:0001722)15190920691302615Rat
1358192Ept13Estrogen-induced pituitary tumorigenesis QTL 133.4pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)186622262131622262Rat
6903308Scl36Serum cholesterol QTL 3620.0125blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)158769992103769992Rat
2300164Bmd44Bone mineral density QTL 445.40.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)166077886111077886Rat
2313092Bmd72Bone mineral density QTL 722.50.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)14630261591302615Rat
2313097Bss70Bone structure and strength QTL 703.50.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)14630261591302615Rat
10054135Gmadr2Adrenal mass QTL 21.970.0129adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)186993904131993904Rat
152025249Scl82Serum cholesterol level QTL 824.77blood cholesterol amount (VT:0000180)152891222109116986Rat
7411712Strs4Sensitivity to stroke QTL 48.7cerebrum integrity trait (VT:0010549)percentage of study population developing cerebrovascular lesions during a period of time (CMO:0000932)187558587132558587Rat
4889919Bss86Bone structure and strength QTL 864.1tibia area (VT:1000281)tibia midshaft total cross-sectional area (CMO:0001715)14630261591302615Rat

Markers in Region
RH133112  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2179,561,340 - 79,561,528 (+)MAPPERmRatBN7.2
Rnor_6.0180,820,353 - 80,820,540NCBIRnor6.0
Rnor_5.0182,085,602 - 82,085,789UniSTSRnor5.0
RGSC_v3.4179,213,701 - 79,213,888UniSTSRGSC3.4
Celera174,018,508 - 74,018,695UniSTS
RH 3.4 Map1787.1UniSTS
Cytogenetic Map1q22UniSTS
RH142229  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2179,561,654 - 79,561,824 (+)MAPPERmRatBN7.2
Rnor_6.0180,820,667 - 80,820,836NCBIRnor6.0
Rnor_5.0182,085,916 - 82,086,085UniSTSRnor5.0
RGSC_v3.4179,214,015 - 79,214,184UniSTSRGSC3.4
Celera174,018,822 - 74,018,991UniSTS
RH 3.4 Map1819.8UniSTS
Cytogenetic Map1q22UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 161 91 90 59 90 59 6 354 190 11 140 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000064305   ⟹   ENSRNOP00000061458
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl188,688,981 - 88,704,630 (-)Ensembl
mRatBN7.2 Ensembl179,546,879 - 79,576,715 (-)Ensembl
Rnor_6.0 Ensembl180,820,050 - 80,835,701 (-)Ensembl
RefSeq Acc Id: NM_017076   ⟹   NP_058772
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8188,689,235 - 88,704,641 (-)NCBI
mRatBN7.2179,561,294 - 79,576,700 (-)NCBI
Rnor_6.0180,820,306 - 80,835,712 (-)NCBI
Rnor_5.0182,085,555 - 82,100,961 (-)NCBI
RGSC_v3.4179,213,654 - 79,229,063 (-)RGD
Celera174,018,461 - 74,033,867 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_058772 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAB80767 (Get FASTA)   NCBI Sequence Viewer  
  AAD25486 (Get FASTA)   NCBI Sequence Viewer  
  AAF13362 (Get FASTA)   NCBI Sequence Viewer  
  AAH85741 (Get FASTA)   NCBI Sequence Viewer  
  EDM08126 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000061458
  ENSRNOP00000061458.1
RefSeq Acc Id: NP_058772   ⟸   NM_017076
- Peptide Label: precursor
- UniProtKB: Q5U334 (UniProtKB/TrEMBL),   A6J8V8 (UniProtKB/TrEMBL),   Q9R1E1 (UniProtKB/TrEMBL),   F7FK02 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000061458   ⟸   ENSRNOT00000064305
Protein Domains
Ig-like

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q5U334-F1-model_v2 AlphaFold Q5U334 1-412 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13689784
Promoter ID:EPDNEW_R309
Type:single initiation site
Name:PVR_1
Description:poliovirus receptor
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0180,835,733 - 80,835,793EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3813 AgrOrtholog
BioCyc Gene G2FUF-60480 BioCyc
Ensembl Genes ENSRNOG00000019202 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000064305 ENTREZGENE
  ENSRNOT00000064305.5 UniProtKB/TrEMBL
Gene3D-CATH 2.60.40.10 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7191422 IMAGE-MGC_LOAD
InterPro CD80_C2-set UniProtKB/TrEMBL
  Ig-like UniProtKB/TrEMBL
  Ig-like_dom_sf UniProtKB/TrEMBL
  Ig-like_fold UniProtKB/TrEMBL
  Ig_sub UniProtKB/TrEMBL
  Ig_V-set UniProtKB/TrEMBL
  Nectin/PVR UniProtKB/TrEMBL
KEGG Report rno:25066 UniProtKB/TrEMBL
MGC_CLONE MGC:93502 IMAGE-MGC_LOAD
NCBI Gene 25066 ENTREZGENE
PANTHER NECTIN-2 UniProtKB/TrEMBL
  PVR CELL ADHESION MOLECULE UniProtKB/TrEMBL
Pfam C2-set_2 UniProtKB/TrEMBL
  Ig_3 UniProtKB/TrEMBL
  V-set UniProtKB/TrEMBL
PhenoGen Pvr PhenoGen
PROSITE IG_LIKE UniProtKB/TrEMBL
RatGTEx ENSRNOG00000019202 RatGTEx
SMART IGv UniProtKB/TrEMBL
  SM00409 UniProtKB/TrEMBL
Superfamily-SCOP SSF48726 UniProtKB/TrEMBL
UniProt A6J8V8 ENTREZGENE, UniProtKB/TrEMBL
  F7FK02 ENTREZGENE, UniProtKB/TrEMBL
  Q5U334 ENTREZGENE
  Q9R1E1 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary Q5U334 UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-04-03 Pvr  PVR cell adhesion molecule  PVR  poliovirus receptor  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-09-10 PVR  poliovirus receptor  Taa1  tumor-associated antigen 1  Symbol and Name updated 1299863 APPROVED
2003-04-09 Taa1  tumor-associated antigen 1  Tage4  tumor-associated glycoprotein pE4  Symbol and Name updated 629477 APPROVED
2002-06-10 Tage4  tumor-associated glycoprotein pE4      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_disease overexpressed in colon tumors 68704
gene_process may mediate entry of some viruses 68704
gene_product member of the immunoglobulin superfamily 68704