Sstr2 (somatostatin receptor 2) - Rat Genome Database

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Gene: Sstr2 (somatostatin receptor 2) Rattus norvegicus
Analyze
Symbol: Sstr2
Name: somatostatin receptor 2
RGD ID: 3763
Description: Enables PDZ domain binding activity and somatostatin receptor activity. Involved in several processes, including brain development; cellular response to estradiol stimulus; and peristalsis. Predicted to be located in cytosol; membrane; and nucleoplasm. Predicted to be part of G protein-coupled receptor heterodimeric complex. Predicted to be active in neuron projection and plasma membrane. Orthologous to human SSTR2 (somatostatin receptor 2); INTERACTS WITH (+)-pilocarpine; 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: Smstr2; somatostatin receptor subtype 2; somatostatin receptor type 2; somatotropin release-inhibiting factor receptor; SRIF-1; SS-2-R; SS2-R; SS2R
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81099,163,353 - 99,170,519 (+)NCBIGRCr8
mRatBN7.21098,664,204 - 98,671,370 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1098,664,216 - 98,674,351 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx10103,716,316 - 103,723,467 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.010103,179,358 - 103,186,509 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01098,584,256 - 98,591,422 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.010102,136,283 - 102,143,449 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl10102,136,283 - 102,143,434 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.010101,816,029 - 101,823,337 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.410103,246,880 - 103,254,444 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.110103,261,249 - 103,268,805 (+)NCBI
Celera1097,271,562 - 97,278,691 (+)NCBICelera
Cytogenetic Map10q32.1NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model



  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Sstr2RatBrain Injuries  IEP 2325002 RGD 
Sstr2RatExperimental Diabetes Mellitus  IEP 2325008 RGD 
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Sstr2Ratneuroendocrine tumor  ISOSSTR2 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:17625444
Sstr2Ratpancreatic cancer  ISOSSTR2 (Homo sapiens)11554173CTD more ...CTDPMID:15259086 more ...
Sstr2Ratparaganglioma  ISOSSTR2 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:29163802
Sstr2Ratstatus epilepticus  ISOSSTR2 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:18951627

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Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Sstr2Rat(+)-pilocarpine increases expressionEXP 6480464Pilocarpine results in increased expression of SSTR2 proteinCTDPMID:18951627
Sstr2Rat17alpha-ethynylestradiol increases expressionISOSstr2 (Mus musculus)6480464Ethinyl Estradiol results in increased expression of SSTR2 mRNACTDPMID:17942748
Sstr2Rat17alpha-ethynylestradiol multiple interactionsISOSstr2 (Mus musculus)6480464[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of SSTR2 mRNACTDPMID:17942748
Sstr2Rat17alpha-ethynylestradiol affects expressionISOSstr2 (Mus musculus)6480464Ethinyl Estradiol affects the expression of SSTR2 mRNACTDPMID:17555576
Sstr2Rat2,3,7,8-tetrachlorodibenzodioxine multiple interactionsISOSstr2 (Mus musculus)6480464[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of SSTR2 mRNACTDPMID:17942748
Sstr2Rat2,3,7,8-tetrachlorodibenzodioxine increases expressionEXP 6480464Tetrachlorodibenzodioxin results in increased expression of SSTR2 mRNACTDPMID:32109520
Sstr2Rat2,3,7,8-tetrachlorodibenzodioxine increases expressionISOSstr2 (Mus musculus)6480464Tetrachlorodibenzodioxin results in increased expression of SSTR2 mRNACTDPMID:17942748
Sstr2Rat3',5'-cyclic AMP multiple interactionsISOSSTR2 (Homo sapiens)6480464[64Cu-CB-TE2A-Y3-TATE co-treated with SSTR2 protein] inhibits the reaction [Colforsin results in increased chemical synthesis of Cyclic AMP] and [SST protein co-treated with SSTR2 protein] inhibits the reaction [Colforsin results in increased chemical synthesis of Cyclic AMP]CTDPMID:22056254
Sstr2Rat3,4-methylenedioxymethamphetamine decreases expressionISOSstr2 (Mus musculus)6480464N-Methyl-3 and 4-methylenedioxyamphetamine results in decreased expression of SSTR2 mRNACTDPMID:19285098
Sstr2Rat4,4'-diaminodiphenylmethane increases expressionISOSstr2 (Mus musculus)64804644 and 4'-diaminodiphenylmethane results in increased expression of SSTR2 mRNACTDPMID:18648102
Sstr2Rat6-propyl-2-thiouracil affects expressionEXP 6480464Propylthiouracil affects the expression of SSTR2 mRNACTDPMID:24780913
Sstr2Rat6-propyl-2-thiouracil decreases expressionEXP 6480464Propylthiouracil results in decreased expression of SSTR2 mRNACTDPMID:30047161
Sstr2Rataflatoxin B1 decreases expressionISOSstr2 (Mus musculus)6480464Aflatoxin B1 results in decreased expression of SSTR2 mRNACTDPMID:19770486
Sstr2Rataflatoxin B1 increases methylationISOSSTR2 (Homo sapiens)6480464Aflatoxin B1 results in increased methylation of SSTR2 exonCTDPMID:30157460
Sstr2Ratall-trans-retinoic acid decreases expressionISOSSTR2 (Homo sapiens)6480464Tretinoin results in decreased expression of SSTR2 mRNACTDPMID:21934132 and PMID:23724009
Sstr2Ratall-trans-retinoic acid increases expressionISOSstr2 (Mus musculus)6480464Tretinoin results in increased expression of SSTR2 mRNACTDPMID:36189433
Sstr2Ratamitrole decreases expressionEXP 6480464Amitrole results in decreased expression of SSTR2 mRNACTDPMID:30047161
Sstr2Ratammonium chloride affects expressionEXP 6480464Ammonium Chloride affects the expression of SSTR2 mRNACTDPMID:16483693
Sstr2Rataristolochic acid A increases expressionISOSSTR2 (Homo sapiens)6480464aristolochic acid I results in increased expression of SSTR2 mRNACTDPMID:33212167
Sstr2Ratarsenous acid decreases expressionISOSSTR2 (Homo sapiens)6480464Arsenic Trioxide results in decreased expression of SSTR2 mRNACTDPMID:26705709

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Biological Process
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Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Sstr2Ratadenylate cyclase-inhibiting G protein-coupled receptor signaling pathway acts_upstream_of_or_withinISOSstr2 (Mus musculus)1624291 PMID:9166719RGDPMID:9166719
Sstr2Ratcellular response to estradiol stimulus  IEP 2325004 RGD 
Sstr2Ratcellular response to estradiol stimulus involved_inIBAPANTHER:PTN002796148 and Sstr2 (Rattus norvegicus)1600115GO_REF:0000033GO_CentralGO_REF:0000033
Sstr2Ratcellular response to glucocorticoid stimulus  IEP 2325001 RGD 
Sstr2Ratcellular response to glucocorticoid stimulus involved_inIBAPANTHER:PTN002796148 and Sstr2 (Rattus norvegicus)1600115GO_REF:0000033GO_CentralGO_REF:0000033
Sstr2Ratcellular response to hormone stimulus involved_inIEAARBA:ARBA000266441600115GO_REF:0000117UniProtGO_REF:0000117
Sstr2Ratcellular response to lipid involved_inIEAARBA:ARBA000278031600115GO_REF:0000117UniProtGO_REF:0000117
Sstr2Ratcerebellum development  IEP 2325007 RGD 
Sstr2Ratforebrain development  IEP 2325003 RGD 
Sstr2RatG protein-coupled receptor signaling pathway acts_upstream_of_or_withinISOSstr2 (Mus musculus)1624291 PMID:7929134RGDPMID:7929134
Sstr2RatG protein-coupled receptor signaling pathway involved_inIEAInterPro:IPR000276 more ...1600115GO_REF:0000002InterProGO_REF:0000002
Sstr2RatG protein-coupled receptor signaling pathway involved_inIEAUniProtKB-KW:KW-02971600115GO_REF:0000043UniProtGO_REF:0000043
Sstr2Ratnegative regulation of growth hormone secretion involved_inISOSSTR2 (Sus scrofa)1624291 PMID:16543371RGDPMID:16543371
Sstr2Ratneuropeptide signaling pathway acts_upstream_of_or_withinISOSstr2 (Mus musculus)1624291 PMID:9166719RGDPMID:9166719
Sstr2Ratneuropeptide signaling pathway involved_inIBAFB:FBgn0036789 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Sstr2Ratperistalsis  IMP 727490 RGD 
Sstr2Ratresponse to starvation  IEP 2325008 RGD 
Sstr2Ratsignal transduction involved_inIEAUniProtKB-KW:KW-08071600115GO_REF:0000043UniProtGO_REF:0000043
Sstr2Ratsomatostatin signaling pathway involved_inIEAGO:00049941600115GO_REF:0000108GOCGO_REF:0000108
Sstr2Ratspermatogenesis  IEP 2325005 RGD 
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Cellular Component
1 to 14 of 14 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Sstr2Ratcytoplasm located_inIEAUniProtKB-SubCell:SL-00861600115GO_REF:0000044UniProtGO_REF:0000044
Sstr2Ratcytoplasm located_inIEAUniProtKB-KW:KW-09631600115GO_REF:0000043UniProtGO_REF:0000043
Sstr2Ratcytosol located_inISOSSTR2 (Homo sapiens) and UniProtKB:P30874-11624291 RGDGO_REF:0000052
Sstr2RatG protein-coupled receptor heterodimeric complex part_ofISOSSTR2 (Sus scrofa)1624291 PMID:24368669RGDPMID:24368669
Sstr2Ratmembrane located_inISOSstr2 (Mus musculus)1624291 PMID:7929134RGDPMID:7929134
Sstr2Ratmembrane located_inIEAUniProtKB-KW:KW-04721600115GO_REF:0000043UniProtGO_REF:0000043
Sstr2Ratmembrane located_inIEAInterPro:IPR000276 more ...1600115GO_REF:0000002InterProGO_REF:0000002
Sstr2Ratneuron projection is_active_inIBAMGI:2180756 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Sstr2Ratnucleoplasm located_inISOSSTR2 (Homo sapiens) and UniProtKB:P30874-11624291 RGDGO_REF:0000052
Sstr2Ratplasma membrane located_inISOSSTR2 (Sus scrofa)1624291 PMID:24368669RGDPMID:24368669
Sstr2Ratplasma membrane located_inISOSstr2 (Mus musculus)1624291 PMID:9166719RGDPMID:9166719
Sstr2Ratplasma membrane is_active_inIBAFB:FBgn0036789 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Sstr2Ratplasma membrane located_inIEAUniProtKB-KW:KW-10031600115GO_REF:0000043UniProtGO_REF:0000043
Sstr2Ratplasma membrane located_inIEAUniProtKB-SubCell:SL-00391600115GO_REF:0000044UniProtGO_REF:0000044
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Molecular Function
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#
Reference Title
Reference Citation
1. Somatostatin sst(2) receptors inhibit peristalsis in the rat and mouse jejunum. Abdu F, etal., Am J Physiol Gastrointest Liver Physiol 2002 Apr;282(4):G624-33.
2. Gain of chromosome arm 17q is associated with unfavourable prognosis in neuroblastoma, but does not involve mutations in the somatostatin receptor 2(SSTR2) gene at 17q24. Abel F, etal., Br J Cancer 1999 Dec;81(8):1402-9.
3. Identification of multiple somatostatin receptors in the rat somatosensory cortex during development. Bologna E and Leroux P, J Comp Neurol. 2000 May 15;420(4):466-80.
4. Expression changes of somatostatin receptor subtypes sst2A, sst2B, sst3 and sst4 after a cortical contusion trauma in rats. Braun H, etal., Brain Res. 2002 Mar 15;930(1-2):191-9.
5. Pituitary and hypothalamic somatostatin receptor subtype messenger ribonucleic acid expression in the food-deprived and diabetic rat. Bruno JF, etal., Endocrinology. 1994 Nov;135(5):1787-92.
6. Intra-islet somatostatin regulates glucagon release via type 2 somatostatin receptors in rats. Cejvan K, etal., Diabetes 2003 May;52(5):1176-81.
7. Inhibitory control of growth hormone secretion by somatostatin in rat pituitary GC cells: sst(2) but not sst(1) receptors are coupled to inhibition of single-cell intracellular free calcium concentrations. Cervia D, etal., Neuroendocrinology 2002 Aug;76(2):99-110.
8. Effect of 17beta-estradiol on somatostatin receptor expression and inhibitory effects on growth hormone and prolactin release in rat pituitary cell cultures. Djordjijevic D, etal., Endocrinology. 1998 May;139(5):2272-7.
9. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
10. Expression cloning of a rat brain somatostatin receptor cDNA. Kluxen FW, etal., Proc Natl Acad Sci U S A 1992 May 15;89(10):4618-22.
11. Identification of proteins interacting with the rat somatostatin receptor subtype 2. Kreienkamp HJ, etal., J Physiol Paris. 2000 May-Aug;94(3-4):193-8.
12. Expression of the five somatostatin receptor (SSTR1-5) subtypes in rat pituitary somatotrophes: quantitative analysis by double-layer immunofluorescence confocal microscopy. Kumar U, etal., Endocrinology. 1997 Oct;138(10):4473-6.
13. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
14. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
15. Role of glucocorticoids in the regulation of pituitary somatostatin receptor subtype (sst1-sst5) mRNA levels: evidence for direct and somatostatin-mediated effects. Park S, etal., Neuroendocrinology. 2003 Sep;78(3):163-75.
16. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
17. Somatostatin immunoreactivity in axon terminals in rat nucleus tractus solitarii arising from central nucleus of amygdala: coexistence with GABA and postsynaptic expression of sst2A receptor. Saha S, etal., J Chem Neuroanat 2002 Jun;24(1):1-13.
18. Spinal somatostatin SSTR2A receptors are preferentially up-regulated and involved in thermonociception but not mechanonociception. Song P, etal., Exp Neurol 2002 Dec;178(2):280-7.
19. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
20. Differential expression of multiple somatostatin receptors in the rat cerebellum during development. Viollet C, etal., J Neurochem. 1997 Jun;68(6):2263-72.
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PMID:1346068   PMID:1348934   PMID:7929134   PMID:8386508   PMID:9166719   PMID:9437026   PMID:10373412   PMID:11250922   PMID:12403839   PMID:12639941   PMID:12665520   PMID:12895520  
PMID:15601946   PMID:15728843   PMID:16000155   PMID:16280179   PMID:16379030   PMID:16543371   PMID:17327372   PMID:17347306   PMID:17521381   PMID:17603546   PMID:17617126   PMID:17706880  
PMID:17706924   PMID:18363859   PMID:18566118   PMID:18793718   PMID:18795252   PMID:19001189   PMID:19434240   PMID:19910453   PMID:20814067   PMID:21539874   PMID:21795688   PMID:23073237  
PMID:23473742   PMID:23913690   PMID:24368669   PMID:24412308   PMID:24828612   PMID:24846611   PMID:24978951   PMID:25926390   PMID:26311777   PMID:26462807   PMID:28991052   PMID:29380671  
PMID:29522573   PMID:30291955   PMID:30544226   PMID:30609928   PMID:32315148   PMID:33045023   PMID:34487822  



Sstr2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81099,163,353 - 99,170,519 (+)NCBIGRCr8
mRatBN7.21098,664,204 - 98,671,370 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1098,664,216 - 98,674,351 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx10103,716,316 - 103,723,467 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.010103,179,358 - 103,186,509 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01098,584,256 - 98,591,422 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.010102,136,283 - 102,143,449 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl10102,136,283 - 102,143,434 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.010101,816,029 - 101,823,337 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.410103,246,880 - 103,254,444 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.110103,261,249 - 103,268,805 (+)NCBI
Celera1097,271,562 - 97,278,691 (+)NCBICelera
Cytogenetic Map10q32.1NCBI
SSTR2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381773,165,010 - 73,176,633 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1773,165,010 - 73,176,633 (+)EnsemblGRCh38hg38GRCh38
GRCh371771,161,149 - 71,172,772 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361768,672,755 - 68,679,689 (+)NCBINCBI36Build 36hg18NCBI36
Build 341768,672,754 - 68,679,655NCBI
Celera1767,744,235 - 67,751,169 (+)NCBICelera
Cytogenetic Map17q25.1NCBI
HuRef1766,570,255 - 66,577,187 (+)NCBIHuRef
CHM1_11771,225,325 - 71,232,224 (+)NCBICHM1_1
T2T-CHM13v2.01774,054,801 - 74,066,425 (+)NCBIT2T-CHM13v2.0
Sstr2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3911113,510,153 - 113,516,854 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl11113,510,168 - 113,516,854 (+)EnsemblGRCm39 Ensembl
GRCm3811113,619,327 - 113,626,028 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl11113,619,342 - 113,626,028 (+)EnsemblGRCm38mm10GRCm38
MGSCv3711113,485,571 - 113,486,950 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3611113,435,574 - 113,441,985 (+)NCBIMGSCv36mm8
Celera11125,379,798 - 125,381,177 (+)NCBICelera
Cytogenetic Map11E2NCBI
cM Map1179.05NCBI
Sstr2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495547860,489 - 90,209 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495547861,126 - 123,806 (-)NCBIChiLan1.0ChiLan1.0
SSTR2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21989,182,442 - 89,194,105 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11794,007,294 - 94,018,946 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01767,093,013 - 67,099,086 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11772,549,167 - 72,556,106 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1772,553,506 - 72,554,615 (+)Ensemblpanpan1.1panPan2
SSTR2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.196,989,488 - 7,004,851 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl96,996,874 - 7,000,778 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha97,620,598 - 7,621,707 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.097,662,314 - 7,677,653 (-)NCBIROS_Cfam_1.0
UMICH_Zoey_3.197,712,309 - 7,713,418 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.097,815,153 - 7,816,262 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.097,876,175 - 7,877,284 (-)NCBIUU_Cfam_GSD_1.0
Sstr2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244056027,552,830 - 7,558,761 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366551,051,447 - 1,052,556 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366551,050,835 - 1,056,609 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SSTR2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl127,783,431 - 7,789,488 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1127,783,401 - 7,789,483 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2128,063,456 - 8,069,876 (-)NCBISscrofa10.2Sscrofa10.2susScr3
SSTR2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11648,462,472 - 48,470,586 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1648,464,342 - 48,465,451 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607719,280,096 - 19,290,449 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Sstr2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248013,198,204 - 3,206,481 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248013,198,137 - 3,205,936 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

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Variants in Sstr2
74 total Variants

Predicted Target Of
Summary Value
Count of predictions:98
Count of miRNA genes:77
Interacting mature miRNAs:87
Transcripts:ENSRNOT00000003734, ENSRNOT00000003735
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


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The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
1354641Bvd2Brain ventricular dilatation QTL 26.360.001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)1093223816107057807Rat
61449Ciaa2CIA Autoantibody QTL 27.1blood autoantibody amount (VT:0003725)calculated serum anti-type 2 collagen antibody titer (CMO:0001279)1063221094107211142Rat
61325Aia5Adjuvant induced arthritis QTL 50.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
1298078Stresp5Stress response QTL 52.990.00025blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)1042045676104670812Rat
1549831Bss6Bone structure and strength QTL 64lumbar vertebra strength trait (VT:0010574)vertebra ultimate force (CMO:0001678)1057576521102576521Rat
1579915Bp280Blood pressure QTL 2800.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1090404397107211142Rat
70164Bw21Body weight QTL 214.360.00005body mass (VT:0001259)body weight (CMO:0000012)105379749498952626Rat
2298548Neuinf7Neuroinflammation QTL 73.4nervous system integrity trait (VT:0010566)spinal cord RT1-B protein level (CMO:0002132)1072224939107211142Rat
1302404Cia27Collagen induced arthritis QTL 272.60.0045joint integrity trait (VT:0010548)experimental arthritis severity measurement (CMO:0001459)1076452683107211142Rat
2317754Glom25Glomerulus QTL 253.5urine protein amount (VT:0005160)urine protein level (CMO:0000591)1082685200107211142Rat

1 to 10 of 67 rows
AU047965  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21098,665,236 - 98,665,482 (+)MAPPERmRatBN7.2
Rnor_6.010102,137,316 - 102,137,561NCBIRnor6.0
Rnor_5.010101,817,062 - 101,817,307UniSTSRnor5.0
RGSC_v3.410103,247,913 - 103,248,158UniSTSRGSC3.4
Celera1097,272,595 - 97,272,840UniSTS
Cytogenetic Map10q32.1UniSTS
SSTR2  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21098,669,935 - 98,670,339 (+)MAPPERmRatBN7.2
Rnor_6.010102,142,015 - 102,142,418NCBIRnor6.0
Rnor_5.010101,821,903 - 101,822,306UniSTSRnor5.0
RGSC_v3.410103,253,010 - 103,253,413UniSTSRGSC3.4
Celera1097,277,257 - 97,277,660UniSTS
Cytogenetic Map10q32.1UniSTS




alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 6 22 113 78 77 46 24 46 6 169 66 93 42 56 31



Ensembl Acc Id: ENSRNOT00000003735   ⟹   ENSRNOP00000003735
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1098,664,357 - 98,671,080 (+)Ensembl
Rnor_6.0 Ensembl10102,136,283 - 102,143,434 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000116317   ⟹   ENSRNOP00000094133
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1098,664,216 - 98,674,351 (+)Ensembl
RefSeq Acc Id: NM_019348   ⟹   NP_062221
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81099,163,353 - 99,170,519 (+)NCBI
mRatBN7.21098,664,204 - 98,671,370 (+)NCBI
Rnor_6.010102,136,283 - 102,143,449 (+)NCBI
Rnor_5.010101,816,029 - 101,823,337 (+)NCBI
RGSC_v3.410103,246,880 - 103,254,444 (+)RGD
Celera1097,271,562 - 97,278,691 (+)RGD
Sequence:
1 to 10 of 10 rows
Protein RefSeqs NP_062221 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA42165 (Get FASTA)   NCBI Sequence Viewer  
  AAA42166 (Get FASTA)   NCBI Sequence Viewer  
  CAA66886 (Get FASTA)   NCBI Sequence Viewer  
  EDM06514 (Get FASTA)   NCBI Sequence Viewer  
  EDM06515 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000003735.3
  ENSRNOP00000094133.1
  ENSRNOP00000110504
GenBank Protein P30680 (Get FASTA)   NCBI Sequence Viewer  
1 to 10 of 10 rows
RefSeq Acc Id: NP_062221   ⟸   NM_019348
- UniProtKB: P30680 (UniProtKB/Swiss-Prot),   A6HKG0 (UniProtKB/TrEMBL),   A6HKF9 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000003735   ⟸   ENSRNOT00000003735
Ensembl Acc Id: ENSRNOP00000094133   ⟸   ENSRNOT00000116317
Name Modeler Protein Id AA Range Protein Structure
AF-P30680-F1-model_v2 AlphaFold P30680 1-369 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen



1 to 28 of 28 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-22761 BioCyc
Ensembl Genes ENSRNOG00000002793 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000003735.4 UniProtKB/Swiss-Prot
  ENSRNOT00000116317.1 UniProtKB/Swiss-Prot
  ENSRNOT00000133830 ENTREZGENE
Gene3D-CATH Rhodopsin 7-helix transmembrane proteins UniProtKB/Swiss-Prot
InterPro GPCR_Rhodpsn UniProtKB/Swiss-Prot
  GPCR_Rhodpsn_7TM UniProtKB/Swiss-Prot
  Somatstn_rcpt UniProtKB/Swiss-Prot
  Somatstn_rcpt_2 UniProtKB/Swiss-Prot
KEGG Report rno:54305 UniProtKB/Swiss-Prot
NCBI Gene 54305 ENTREZGENE
PANTHER NEUROPEPTIDES RECEPTOR UniProtKB/Swiss-Prot
  SOMATOSTATIN RECEPTOR TYPE 2 UniProtKB/Swiss-Prot
Pfam 7tm_1 UniProtKB/Swiss-Prot
PhenoGen Sstr2 PhenoGen
PRINTS GPCRRHODOPSN UniProtKB/Swiss-Prot
  SOMATOSTATNR UniProtKB/Swiss-Prot
  SOMATOSTTN2R UniProtKB/Swiss-Prot
PROSITE G_PROTEIN_RECEP_F1_1 UniProtKB/Swiss-Prot
  G_PROTEIN_RECEP_F1_2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000002793 RatGTEx
SMART 7TM_GPCR_Srsx UniProtKB/Swiss-Prot
Superfamily-SCOP Family A G protein-coupled receptor-like UniProtKB/Swiss-Prot
TIGR TC223639
UniProt A6HKF9 ENTREZGENE, UniProtKB/TrEMBL
  A6HKG0 ENTREZGENE, UniProtKB/TrEMBL
  P30680 ENTREZGENE, UniProtKB/Swiss-Prot
1 to 28 of 28 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2003-04-09 Sstr2  somatostatin receptor 2      Symbol and Name updated 629477 APPROVED
2003-03-12 Sstr2  somatostatin receptor 2  Smstr2  somatostatin receptor 2  Data merged from RGD:620193 628472 PROVISIONAL
2002-08-07 Smstr2  somatostatin receptor 2      Symbol and Name status set to provisional 70820 PROVISIONAL
2002-06-10 Sstr2  somatostatin receptor subtype 2      Name updated 70584 APPROVED

Note Type Note Reference
gene_expression expressed in brain cortex and hippocampus 70025
gene_physical_interaction binds to somatotropin release-inhibiting factor (SRIF) 70025
gene_process inhibits peristalsis in the jejunum upon binding to somatostatin 737668
gene_process may modulate activity of neurons in nucleus tractus solitarii from the central nucleus of the amygdala in response to fear or emotional stimuli 730237
gene_process activation with somatostatin inhibits release of glucagon but not insulin in islets 1299053
gene_product putative transmembrane G-protein coupled receptor 70025