Spn (sialophorin) - Rat Genome Database

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Gene: Spn (sialophorin) Rattus norvegicus
Analyze
Symbol: Spn
Name: sialophorin
RGD ID: 3750
Description: Enables protein domain specific binding activity. Involved in several processes, including T cell receptor signaling pathway; monocyte activation; and thymocyte aggregation. Located in cell surface; cleavage furrow; and microvillus. Orthologous to human SPN (sialophorin); INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 4-amino-2,6-dinitrotoluene.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Cd43; gpL115; leukocyte sialoglycoprotein; Leukosialin; leukosianin; Lsn; Lsn1; Sialophorin (gpL115 leukosianin CD43); Sialophorin (gpL115, leukosianin, CD43); W3/13 antigen
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Is Marker For: Strains:   SD-Del(Sult1a1-Spn)/YahIcsOrl   SD-Dp(Sult1a1-Spn)/YahIcsOrl  
QTLs:   Bp43   Pancm1   Iddm10   Bp84  
Candidate Gene For: Pancm1
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81191,177,449 - 191,190,115 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1191,178,096 - 191,187,852 (-)EnsemblGRCr8
mRatBN7.21181,746,937 - 181,759,564 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1181,746,429 - 181,759,628 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1190,098,274 - 190,102,501 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01197,284,362 - 197,288,589 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01189,953,011 - 189,957,242 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01198,572,999 - 198,585,664 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1198,572,999 - 198,577,226 (-)Ensemblrn6Rnor6.0
Rnor_5.01205,563,659 - 205,576,290 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41186,388,120 - 186,391,887 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1179,399,985 - 179,404,212 (-)NCBICelera
RGSC_v3.11186,538,248 - 186,541,733 (-)NCBI
Cytogenetic Map1q37NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2-palmitoylglycerol  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-amino-2,6-dinitrotoluene  (EXP)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
aflatoxin B1  (EXP)
Aflatoxin B2 alpha  (ISO)
all-trans-retinoic acid  (ISO)
alpha-Zearalanol  (EXP)
amitrole  (EXP)
ammonium chloride  (EXP)
amphetamine  (EXP)
antirheumatic drug  (ISO)
atropine  (ISO)
aurantio-obtusin  (ISO)
Azoxymethane  (ISO)
benzo[a]pyrene  (ISO)
Benzo[k]fluoranthene  (ISO)
beta-lapachone  (ISO)
bisphenol A  (EXP,ISO)
bortezomib  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
carbon nanotube  (ISO)
chloroprene  (EXP,ISO)
chlorpyrifos  (ISO)
chromium(6+)  (ISO)
cisplatin  (EXP)
copper atom  (EXP)
copper(0)  (EXP)
Cuprizon  (EXP)
dextran sulfate  (ISO)
Dibutyl phosphate  (ISO)
dicrotophos  (ISO)
digitonin  (ISO)
diuron  (ISO)
doxorubicin  (ISO)
ethanol  (EXP)
folic acid  (ISO)
gadodiamide hydrate  (ISO)
genistein  (ISO)
gentamycin  (EXP)
GSK-J4  (ISO)
lipopolysaccharide  (ISO)
mercury dichloride  (ISO)
methimazole  (EXP)
methyl methanesulfonate  (ISO)
metoprolol  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
N(gamma)-nitro-L-arginine methyl ester  (EXP)
naringin  (EXP)
nickel atom  (ISO)
okadaic acid  (ISO)
ozone  (ISO)
paracetamol  (ISO)
paraquat  (EXP)
perfluorooctane-1-sulfonic acid  (ISO)
prazosin  (ISO)
progesterone  (ISO)
raloxifene  (EXP)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenate  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
triclosan  (ISO)
trimellitic anhydride  (ISO)
trimethaphan  (ISO)
triphenyl phosphate  (ISO)
triptonide  (ISO)
tropan-3alpha-yl 3-hydroxy-2-phenylpropanoate  (ISO)
trovafloxacin  (ISO)
tungsten  (ISO)
valproic acid  (ISO)
venlafaxine hydrochloride  (EXP)
vinclozolin  (EXP)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Identification of two subpopulations of rat monocytes expressing disparate molecular forms and quantities of CD43. Ahuja V, etal., Cell Immunol. 1995 Jun;163(1):59-69.
2. Protective role of sialophorin (CD43)-expressing cells in experimental Staphylococcus aureus infection. Bremell T, etal., Infect Immun. 1994 Oct;62(10):4637-40.
3. Genetic modifiers of Leprfa associated with variability in insulin production and susceptibility to NIDDM. Chung WK, etal., Genomics 1997 May 1;41(3):332-44
4. The importance of cross-linking in the homotypic aggregation of lymphocytes induced by anti-leukosialin (CD43) antibodies. Cyster JG and Williams AF, Eur J Immunol. 1992 Oct;22(10):2565-72.
5. Prenatal stress leads to chromatin and synaptic remodeling and excessive alcohol intake comorbid with anxiety-like behaviors in adult offspring. Dong E, etal., Neuropharmacology. 2018 Sep 15;140:76-85. doi: 10.1016/j.neuropharm.2018.07.010. Epub 2018 Aug 4.
6. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
7. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
8. CD45 ectodomain controls interaction with GEMs and Lck activity for optimal TCR signaling. Irles C, etal., Nat Immunol 2003 Feb;4(2):189-97. Epub 2002 Dec 23.
9. The sequence of rat leukosialin (W3/13 antigen) reveals a molecule with O-linked glycosylation of one third of its extracellular amino acids. Killeen N, etal., EMBO J 1987 Dec 20;6(13):4029-34.
10. Novel quantitative trait loci for blood pressure and related traits on rat chromosomes 1, 10, and 18. Kovacs P, etal., Biochem Biophys Res Commun 1997 Jun 18;235(2):343-8
11. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
12. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
13. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
14. GOA pipeline RGD automated data pipeline
15. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
16. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
17. Rat monocytes up-regulate NKR-P1A and down-modulate CD4 and CD43 during activation in vivo: monocyte subpopulations in normal and IFN-gamma-treated rats. Scriba A, etal., J Leukoc Biol. 1997 Dec;62(6):741-52.
18. An antiserum raised against the recombinant cytoplasmic tail of the human CD43 glycoprotein identifies CD43 in many mammalian species. Szlanka T, etal., Immunology. 1999 Jan;96(1):74-82.
19. Structural basis of the cytoplasmic tail of adhesion molecule CD43 and its binding to ERM proteins. Takai Y, etal., J Mol Biol. 2008 Sep 5;381(3):634-44. Epub 2008 Jun 7.
20. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
21. PECAM-1 and leukosialin (CD43) expression correlate with heightened inflammation in rat adjuvant-induced arthritis. Volin MV, etal., Exp Mol Pathol. 1999 Aug;66(3):211-9.
22. Concentration of an integral membrane protein, CD43 (leukosialin, sialophorin), in the cleavage furrow through the interaction of its cytoplasmic domain with actin-based cytoskeletons. Yonemura S, etal., J Cell Biol. 1993 Jan;120(2):437-49.
23. Ezrin/radixin/moesin (ERM) proteins bind to a positively charged amino acid cluster in the juxta-membrane cytoplasmic domain of CD44, CD43, and ICAM-2. Yonemura S, etal., J Cell Biol. 1998 Feb 23;140(4):885-95.
24. Functional characterization of Delta3,Delta2-enoyl-CoA isomerases from rat liver. Zhang D, etal., J Biol Chem. 2002 Mar 15;277(11):9127-32. Epub 2002 Jan 7.
Additional References at PubMed
PMID:7477353   PMID:7514104   PMID:7566153   PMID:7790813   PMID:7795661   PMID:8920854   PMID:9645617   PMID:10429671   PMID:10899905   PMID:10943842   PMID:11238599   PMID:11380685  
PMID:11728336   PMID:11828253   PMID:11937524   PMID:11994475   PMID:12354383   PMID:14635057   PMID:15117976   PMID:15843532   PMID:17221298   PMID:17638845   PMID:18036228   PMID:19299737  
PMID:19946888   PMID:20333395   PMID:20360400   PMID:20458337   PMID:20605918   PMID:20633027   PMID:21289089   PMID:24250818   PMID:26700769  


Genomics

Comparative Map Data
Spn
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81191,177,449 - 191,190,115 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1191,178,096 - 191,187,852 (-)EnsemblGRCr8
mRatBN7.21181,746,937 - 181,759,564 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1181,746,429 - 181,759,628 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1190,098,274 - 190,102,501 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01197,284,362 - 197,288,589 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01189,953,011 - 189,957,242 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01198,572,999 - 198,585,664 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1198,572,999 - 198,577,226 (-)Ensemblrn6Rnor6.0
Rnor_5.01205,563,659 - 205,576,290 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41186,388,120 - 186,391,887 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1179,399,985 - 179,404,212 (-)NCBICelera
RGSC_v3.11186,538,248 - 186,541,733 (-)NCBI
Cytogenetic Map1q37NCBI
SPN
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381629,662,963 - 29,670,876 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1629,662,979 - 29,670,876 (+)Ensemblhg38GRCh38
GRCh371629,674,284 - 29,682,197 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361629,581,801 - 29,589,329 (+)NCBIBuild 36Build 36hg18NCBI36
Build 34864,262,738 - 64,263,150NCBI
Celera1673,114,178 - 73,121,702 (-)NCBICelera
Cytogenetic Map16p11.2NCBI
HuRef1627,335,753 - 27,343,116 (+)NCBIHuRef
CHM1_11630,686,100 - 30,693,653 (+)NCBICHM1_1
T2T-CHM13v2.01629,945,006 - 29,952,917 (+)NCBIT2T-CHM13v2.0
Spn
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm397126,731,404 - 126,743,785 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl7126,731,404 - 126,736,995 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm387127,123,637 - 127,145,552 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl7127,132,232 - 127,137,823 (-)Ensemblmm10GRCm38
MGSCv377134,276,978 - 134,281,331 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv367126,924,612 - 126,928,965 (-)NCBIMGSCv36mm8
Celera7126,982,004 - 126,986,358 (-)NCBICelera
Cytogenetic Map7F3NCBI
cM Map769.35NCBI
Spn
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049554937,256,505 - 7,258,607 (-)NCBIChiLan1.0ChiLan1.0
SPN
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21830,412,474 - 30,416,344 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11635,809,899 - 35,813,772 (-)NCBINHGRI_mPanPan1
PanPan1.11630,034,739 - 30,037,033 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1630,035,243 - 30,036,445 (+)EnsemblpanPan2panpan1.1
SPN
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1617,770,303 - 17,774,946 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha619,347,439 - 19,352,997 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0617,904,551 - 17,908,967 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl617,904,284 - 17,906,869 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1617,704,496 - 17,710,054 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0617,619,970 - 17,625,528 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0617,935,701 - 17,941,231 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Spn
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024409344124,676,088 - 124,678,845 (-)NCBIHiC_Itri_2
SpeTri2.0NW_00493650112,773,967 - 12,776,642 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SPN
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl317,978,801 - 17,982,864 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1317,978,731 - 17,982,222 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2318,608,470 - 18,612,200 (-)NCBISscrofa10.2Sscrofa10.2susScr3
SPN
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1526,987,810 - 26,990,214 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_0236660682,533,410 - 2,535,788 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Spn
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462478213,471,083 - 13,483,712 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Spn
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1274,744,429 - 74,755,537 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Spn
111 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:60
Count of miRNA genes:52
Interacting mature miRNAs:57
Transcripts:ENSRNOT00000055013
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1578778Pur4Proteinuria QTL 43.30.003urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)1160111531262090437Rat
1354646Kidm18Kidney mass QTL 185.7kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1160573753266453731Rat
1354652Kidm20Kidney mass QTL 204.3kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1186658830266453731Rat
2302378Insul11Insulin level QTL 113.25blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1153679879198679879Rat
1354653Despr9Despair related QTL 90.00019locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)1177339686222339686Rat
1578770Stresp23Stress response QTL 23kidney sympathetic nerve activity (VT:0004050)stimulated renal sympathetic nerve activity to basal renal sympathetic nerve activity ratio (CMO:0001786)1132760429191848948Rat
2293673Bss27Bone structure and strength QTL 2718.630.0001femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)1181059071226059071Rat
61326Eae6Experimental allergic encephalomyelitis QTL 65.3body mass (VT:0001259)change in body weight (CMO:0002045)1182383862191260518Rat
2293677Bss41Bone structure and strength QTL 419.380.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra cross-sectional area (CMO:0001689)1181059071226059071Rat
70160Bw18Body weight QTL 185.7body mass (VT:0001259)body weight (CMO:0000012)1153679879205813246Rat
1549830Bss1Bone structure and strength QTL 14.8femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)1182039247227039247Rat
70163Bw20Body weight QTL 205.1body mass (VT:0001259)body weight (CMO:0000012)1183564652228564652Rat
8694166Bw147Body weight QTL 1476.830.001body mass (VT:0001259)body weight gain (CMO:0000420)1153788989198788989Rat
1354624Cm35Cardiac mass QTL355.7heart left ventricle mass (VT:0007031)calculated heart weight (CMO:0000073)1186658830266453731Rat
1600397Edcs4Endometrial carcinoma susceptibility QTL 42.2uterus morphology trait (VT:0001120)percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759)1176288899270518180Rat
1354636Lmblg1Limb length QTL 16.4tibia length (VT:0004357)tibia length (CMO:0000450)1160573753210707719Rat
1549837Hcar15Hepatocarcinoma resistance QTL 150.05liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1162548015270518180Rat
2293689Bss47Bone structure and strength QTL 477.250.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra trabecular cross-sectional area (CMO:0001692)1181059071226059071Rat
152025235Bw194Body weight QTL 1944.86body mass (VT:0001259)1132966869252856240Rat
1598853Memor3Memory QTL 34.5exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)1152919152268496042Rat
61341Bp26Blood pressure QTL 26arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1139442053223964440Rat
1354634Kidm12Kidney mass QTL 123.9kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)1160573753210707719Rat
4889428Stresp24Stress response QTL 240.05heart pumping trait (VT:2000009)absolute change in electrocardiographic low frequency R-R spectral component to high frequency R-R spectral component ratio (CMO:0002162)1165278545210278545Rat
2293693Bss22Bone structure and strength QTL 2233.520.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)1181059071226059071Rat
1578759Uae30Urinary albumin excretion QTL 303.30.003urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1160111531262090437Rat
61343Bp28Blood pressure QTL 28arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1161077990206077990Rat
152025232Bw192Body weight QTL 1923.93body mass (VT:0001259)1127329268206393015Rat
2300161Bmd43Bone mineral density QTL 438.40.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)1181059071226059071Rat
1358902Bw47Body weight QTL 471.67body mass (VT:0001259)body weight (CMO:0000012)199645382221502378Rat
61347Bp197Blood pressure QTL 1974.2arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)1168063662213063662Rat
61348Bp30Blood pressure QTL 302.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1159894717207261263Rat
2303622Vencon6Ventilatory control QTL 60.001respiration trait (VT:0001943)respiration rate (CMO:0000289)1163992710208992710Rat
8655649Arrd1Age-related retinal degeneration QTL 14.89retinal layer morphology trait (VT:0003727)percentage of study population developing retinopathy during a period of time (CMO:0002453)1109493780193400781Rat
631214Bw61Body weight QTL613.40.0001intramuscular adipose amount (VT:0010044)intramuscular fat area (CMO:0001162)1182535316227535316Rat
7771612Cm80Cardiac mass QTL 808.4heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)1146080545243492863Rat
731168Bp154Blood pressure QTL 1543.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1103779152223964440Rat
631205Bp196Blood pressure QTL 19640.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)198879955208479939Rat
2300174Bmd42Bone mineral density QTL 428.40.0001lumbar vertebra mineral mass (VT:0010511)bone mineral density (CMO:0001226)1181059071226059071Rat
1300158Bp173Blood pressure QTL 1733.48arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)1155359438194575574Rat
737828Hcas3Hepatocarcinoma susceptibility QTL 34.9liver integrity trait (VT:0010547)liver tumorous lesion volume to total liver volume ratio (CMO:0001082)1153679879232414077Rat
1354661Bw33Body weight QTL 335.2body mass (VT:0001259)body weight (CMO:0000012)1160573753266453731Rat
1358886Bp260Blood pressure QTL 2603.67arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1160574007235238518Rat
1331751Bp199Blood pressure QTL 1993.60022arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1116099376191260518Rat
2293654Bss30Bone structure and strength QTL 3032.650.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)1181059071226059071Rat
724531Uae5Urinary albumin excretion QTL 54urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)1160111426262090599Rat
2300187Bmd41Bone mineral density QTL 418.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)1181059071226059071Rat
1641895Bp298Blood pressure QTL 298arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1132760429191848948Rat
70209Niddm23Non-insulin dependent diabetes mellitus QTL 232.82blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1162753891207753891Rat
1354580Scort1Serum corticosterone level QTL 13.4blood corticosterone amount (VT:0005345)blood corticosterone level (CMO:0001172)1154961463266453731Rat
1358294Bw37Body weight QTL 3750.000011body mass (VT:0001259)body weight (CMO:0000012)1180739993225739993Rat
61378Bp43Blood pressure QTL 4322.6arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1191177449205813246Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)151941022208479811Rat
724559Pancm1Pancreatic morphology QTL 17.1islet of Langerhans morphology trait (VT:0005215)pancreatic islet damage composite score (CMO:0001156)1191190115223964326Rat
2312420Pur17Proteinuria QTL 177.10.0001urine protein amount (VT:0005160)urine total protein excretion rate (CMO:0000756)1172718770228180370Rat
10059600Bp378Blood pressure QTL 3783.080.05arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1186298393231298393Rat
1354591Cm36Cardiac mass QTL 364.1heart left ventricle mass (VT:0007031)calculated heart weight (CMO:0000073)1111949780210707719Rat
2312558Glom17Glomerulus QTL 173.90.001kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)1175967553200707874Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134565911208798288Rat
631519Pia11Pristane induced arthritis QTL 115.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)193903998191260518Rat
619614Bp78Blood pressure QTL 780.001arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1178547286206690557Rat
634321Hc1Hypercalciuria QTL 12.91urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)1188241285250779312Rat
724562Rends1Renal damage susceptibility QTL 10.05kidney glomerulus integrity trait (VT:0010546)index of glomerular damage (CMO:0001135)1139442053223964440Rat
2292222Bp307Blood pressure QTL 3073.060.0014arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1186298393231298393Rat
2292220Bp306Blood pressure QTL 3063.470.00087arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1186298393231298393Rat
1354615Cm32Cardiac mass QTL 325.2heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)1111949780210707719Rat
1600380Niddm70Non-insulin dependent diabetes mellitus QTL 703.10.0008blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)1185979875230979875Rat
1354610Bw34Body weight QTL 344.1body mass (VT:0001259)body weight (CMO:0000012)1160573753266453731Rat
1354620Kidm19Kidney mass QTL 194kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1160573753210707719Rat
1576310Schws2Schwannoma susceptibility QTL 20.029nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)1153788989198788989Rat
1354618Kidm15Kidney mass QTL 155kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)1165707719210707719Rat
6903303Scl34Serum cholesterol QTL 342.50.0033blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)1173363824227535316Rat
631544Bp84Blood pressure QTL 845.6arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1132760429191190115Rat
152025212Bw190Body weight QTL 1905.7body mass (VT:0001259)1132966869206393015Rat
1358189Cstrr1Cold stress response QTL 10.0001catecholamine amount (VT:0010543)urine norepinephrine level (CMO:0001629)1132760429191848948Rat
1354606Bp246Blood pressure QTL 2463.6arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)1111949780228180370Rat
738032Hcas5Hepatocarcinoma susceptibility QTL 53.12liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1185857683270518180Rat
2325727Pia41Pristane induced arthritis QTL 41joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1188241285233241285Rat
2325725Eae31Experimental allergic encephalomyelitis QTL 31nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis severity score (CMO:0001419)1188241285197807511Rat
1354602Bw35Body weight QTL 3512.2body mass (VT:0001259)body weight (CMO:0000012)1160573753210707719Rat
7411599Foco11Food consumption QTL 1118.50.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)1153788989198788989Rat
631670Iddm10Insulin dependent diabetes mellitus QTL 101.9blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1183564652205813246Rat

Markers in Region
D12Wox9  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_5.01220,239,828 - 20,239,932NCBIRnor5.0
Rnor_5.01220,239,829 - 20,239,932NCBIRnor5.0
Rnor_5.01205,564,367 - 205,564,501NCBIRnor5.0
Rnor_5.01205,564,366 - 205,564,501NCBIRnor5.0
RGSC_v3.41186,388,833 - 186,388,966UniSTSRGSC3.4
RGSC_v3.41216,601,685 - 16,601,788RGDRGSC3.4
RGSC_v3.41186,388,832 - 186,388,966RGDRGSC3.4
RGSC_v3.41216,601,686 - 16,601,788UniSTSRGSC3.4
Celera1217,843,923 - 17,844,025UniSTS
Celera1179,400,694 - 179,400,827UniSTS
RGSC_v3.11186,538,713 - 186,538,847RGD
RH 3.4 Map12241.0UniSTS
Cytogenetic Map1q36UniSTS
D1Wox20  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_5.01205,563,901 - 205,567,387NCBIRnor5.0
RGSC_v3.41186,388,367 - 186,391,852RGDRGSC3.4
RH 3.4 Map12241.0RGD
RH 2.0 Map12172.1RGD


Related Rat Strains
The following Strains have been annotated to Spn
SD-Del(Sult1a1-Spn)/YahIcsOrl     SD-Dp(Sult1a1-Spn)/YahIcsOrl    


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 160 91 90 59 92 59 6 356 192 11 139 81 92 31 13 13

Sequence


Ensembl Acc Id: ENSRNOT00000055013   ⟹   ENSRNOP00000051894
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1191,178,096 - 191,181,246 (-)Ensembl
mRatBN7.2 Ensembl1181,746,429 - 181,759,628 (-)Ensembl
Rnor_6.0 Ensembl1198,572,999 - 198,577,226 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000100623   ⟹   ENSRNOP00000081397
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1191,178,338 - 191,181,246 (-)Ensembl
mRatBN7.2 Ensembl1181,746,429 - 181,751,629 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000150721   ⟹   ENSRNOP00000100729
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1191,179,440 - 191,187,852 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000157992   ⟹   ENSRNOP00000103347
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1191,178,483 - 191,181,246 (-)Ensembl
RefSeq Acc Id: NM_001271086   ⟹   NP_001258015
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81191,177,449 - 191,181,676 (-)NCBI
mRatBN7.21181,746,937 - 181,751,164 (-)NCBI
Rnor_6.01198,572,999 - 198,577,226 (-)NCBI
Rnor_5.01205,563,659 - 205,576,290 (-)NCBI
Celera1179,399,985 - 179,404,212 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006230213   ⟹   XP_006230275
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81191,177,685 - 191,190,113 (-)NCBI
mRatBN7.21181,747,180 - 181,759,564 (-)NCBI
Rnor_6.01198,573,000 - 198,585,664 (-)NCBI
Rnor_5.01205,563,659 - 205,576,290 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008759858   ⟹   XP_008758080
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81191,177,685 - 191,181,680 (-)NCBI
mRatBN7.21181,747,180 - 181,751,166 (-)NCBI
Rnor_6.01198,573,000 - 198,577,792 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039100858   ⟹   XP_038956786
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81191,177,685 - 191,190,115 (-)NCBI
mRatBN7.21181,747,180 - 181,759,564 (-)NCBI
RefSeq Acc Id: NP_001258015   ⟸   NM_001271086
- Peptide Label: precursor
- UniProtKB: P13838 (UniProtKB/Swiss-Prot),   R9PXZ7 (UniProtKB/TrEMBL),   A6I9L7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006230275   ⟸   XM_006230213
- Peptide Label: isoform X1
- UniProtKB: P13838 (UniProtKB/Swiss-Prot),   R9PXZ7 (UniProtKB/TrEMBL),   A6I9L7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008758080   ⟸   XM_008759858
- Peptide Label: isoform X1
- UniProtKB: P13838 (UniProtKB/Swiss-Prot),   R9PXZ7 (UniProtKB/TrEMBL),   A6I9L7 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000051894   ⟸   ENSRNOT00000055013
RefSeq Acc Id: XP_038956786   ⟸   XM_039100858
- Peptide Label: isoform X1
- UniProtKB: P13838 (UniProtKB/Swiss-Prot),   R9PXZ7 (UniProtKB/TrEMBL),   A6I9L7 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000081397   ⟸   ENSRNOT00000100623
Ensembl Acc Id: ENSRNOP00000103347   ⟸   ENSRNOT00000157992
Ensembl Acc Id: ENSRNOP00000100729   ⟸   ENSRNOT00000150721

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P13838-F1-model_v2 AlphaFold P13838 1-378 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13690426
Promoter ID:EPDNEW_R950
Type:single initiation site
Name:Spn_1
Description:sialophorin
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01198,577,226 - 198,577,286EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3750 AgrOrtholog
BioCyc Gene G2FUF-57387 BioCyc
Ensembl Genes ENSRNOG00000036711 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000055013 ENTREZGENE
InterPro Leukosialin UniProtKB/Swiss-Prot
NCBI Gene 24796 ENTREZGENE
PANTHER LEUKOSIALIN UniProtKB/Swiss-Prot
  PTHR35265 UniProtKB/Swiss-Prot
PhenoGen Spn PhenoGen
RatGTEx ENSRNOG00000036711 RatGTEx
TIGR TC207090
UniProt A0ABK0LFW2_RAT UniProtKB/TrEMBL
  A6I9L7 ENTREZGENE, UniProtKB/TrEMBL
  LEUK_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  R9PXZ7 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2003-04-09 Spn  sialophorin      Name updated 629478 APPROVED
2003-03-07 Spn  sialophorin  Lsn  Leukosialin  Data merged from RGD:61295 628472 PROVISIONAL
2003-03-07   sialophorin  Spn  Sialophorin (gpL115, leukosianin, CD43)  Symbol and Name updated to reflect Human and Mouse nomenclature 61478 PENDING
2002-06-10 Spn  Sialophorin (gpL115, leukosianin, CD43)      Symbol and Name status set to approved 70586 APPROVED
2002-06-10 Lsn  Leukosialin      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_product a third of the extracellular amino acids may be O-glycosylated 729976
gene_protein 371 amino acids 729976