Slc5a1 (solute carrier family 5 member 1) - Rat Genome Database

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Gene: Slc5a1 (solute carrier family 5 member 1) Rattus norvegicus
Analyze
Symbol: Slc5a1
Name: solute carrier family 5 member 1
RGD ID: 3713
Description: Enables D-glucose:sodium symporter activity. Involved in carbohydrate utilization. Located in brush border membrane; cell-cell junction; and organelle. Human ortholog(s) of this gene implicated in glucose-galactose malabsorption. Orthologous to human SLC5A1 (solute carrier family 5 member 1); PARTICIPATES IN lactose degradation pathway; sodium-glucose cotransporter mediated glucose transport pathway; trehalose degradation pathway; INTERACTS WITH 2,2',4,4'-Tetrabromodiphenyl ether; 2,3,7,8-tetrachlorodibenzodioxine; acetamide.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: high affinity sodium-glucose cotransporter; MGC93553; Na(+)/glucose cotransporter 1; SGLT1; SGLT1a; sodium/glucose cotransporter 1; solute carrier family 5 (sodium/glucose cotransporter), member 1; Solute carrier family 5 member alpha 1 (Na+/glucose cotransporter); solute carrier family 5, member 1; Solute carrier family 5, member alpha 1 (Na+/glucose cotransporter)
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81481,778,495 - 81,843,084 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1481,778,348 - 81,846,624 (-)EnsemblGRCr8
mRatBN7.21477,553,990 - 77,618,589 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1477,553,843 - 77,618,547 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1481,996,099 - 82,060,059 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01483,236,643 - 83,300,604 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01479,681,950 - 79,745,920 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01482,910,448 - 82,975,303 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1482,909,981 - 82,975,263 (-)Ensemblrn6Rnor6.0
Rnor_5.01483,595,212 - 83,660,531 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41483,311,232 - 83,370,657 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1476,469,843 - 76,534,501 (-)NCBICelera
RGSC_v3.11483,313,626 - 83,376,968 (-)NCBI
Cytogenetic Map14q21NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-citrinin  (ISO)
(S)-naringenin  (ISO)
1,1-dichloroethene  (ISO)
1,2,4-trichloro-5-(2,5-dichlorophenyl)benzene  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,4'-trichlorobiphenyl  (ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2-hydroxypropanoic acid  (ISO)
4,4'-sulfonyldiphenol  (ISO)
5-fluorouracil  (ISO)
acetamide  (EXP)
aflatoxin B1  (ISO)
aldehydo-D-glucose  (EXP,ISO)
alpha-D-galactose  (ISO)
ammonium chloride  (EXP)
amphotericin B  (ISO)
apigenin  (ISO)
arsane  (EXP,ISO)
arsenic atom  (EXP,ISO)
Azoxymethane  (ISO)
benzo[a]pyrene  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP)
cadmium atom  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
calcium atom  (EXP)
calcium(0)  (EXP)
cannabidiol  (ISO)
carbon nanotube  (ISO)
chloroprene  (EXP)
choline  (ISO)
chromium(6+)  (ISO)
cis-caffeic acid  (ISO)
cisplatin  (EXP)
copper atom  (ISO)
copper(0)  (ISO)
crocidolite asbestos  (ISO)
D-glucose  (EXP,ISO)
dextran sulfate  (ISO)
dibenzo[a,l]pyrene  (ISO)
doxorubicin  (ISO)
ethanol  (ISO)
eugenol  (EXP)
fenvalerate  (EXP)
folic acid  (ISO)
fructose  (EXP,ISO)
galactose  (ISO)
gentamycin  (EXP)
gentamycin C  (ISO)
glucose  (EXP,ISO)
glycerol  (EXP)
GW 4064  (ISO)
hydroquinone  (ISO)
inulin  (ISO)
L-methionine  (ISO)
lead(0)  (EXP)
luteolin  (ISO)
Luteolin-4'-O-glucoside  (ISO)
O-methyleugenol  (ISO)
ochratoxin A  (ISO)
okadaic acid  (ISO)
ozone  (ISO)
paraquat  (EXP)
PCB138  (ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
phlorizin  (EXP,ISO)
quercetin  (ISO)
quercetin 3-O-beta-D-galactopyranoside  (ISO)
quercetin 3-O-beta-D-glucofuranoside  (ISO)
quercetin 3-O-beta-D-glucopyranoside  (ISO)
quercetin 4'-O-beta-D-glucopyranoside  (EXP,ISO)
rac-lactic acid  (ISO)
resveratrol  (ISO)
silicon dioxide  (ISO)
sirolimus  (EXP)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sodium atom  (ISO)
sotorasib  (ISO)
sucrose  (EXP)
sunitinib  (ISO)
Sunset Yellow FCF  (ISO)
tamoxifen  (ISO)
Tesaglitazar  (EXP)
thallium atom  (EXP)
thallium sulfate  (EXP)
titanium dioxide  (ISO)
trametinib  (ISO)
trans-caffeic acid  (ISO)
trans-piceid  (ISO)
tributylstannane  (ISO)
trichloroethene  (EXP)
triclosan  (ISO)
troglitazone  (EXP)
valproic acid  (EXP)
venlafaxine hydrochloride  (EXP)
zinc atom  (ISO)
zinc dichloride  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. The cellular fate of glucose and its relevance in type 2 diabetes. Bouche C, etal., Endocr Rev. 2004 Oct;25(5):807-30.
2. Absorption of quercetin-3-glucoside and quercetin-4'-glucoside in the rat small intestine: the role of lactase phlorizin hydrolase and the sodium-dependent glucose transporter. Day AJ, etal., Biochem Pharmacol 2003 Apr 1;65(7):1199-206.
3. Localization of the Na+-D-glucose cotransporter SGLT1 in the blood-brain barrier. Elfeber K, etal., Histochem Cell Biol. 2004 Mar;121(3):201-7. Epub 2004 Feb 19.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. Asymmetric subcellular distribution of glucose transporters in the endothelium of small contractile arteries. Gaudreault N, etal., Endothelium. 2006 Sep-Oct;13(5):317-24.
6. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
7. Induction of histone H3K4 methylation at the promoter, enhancer, and transcribed regions of the Si and Sglt1 genes in rat jejunum in response to a high-starch/low-fat diet. Inoue S, etal., Nutrition. 2015 Feb;31(2):366-72. doi: 10.1016/j.nut.2014.07.017. Epub 2014 Aug 6.
8. IGF alters jejunal glucose transporter expression and serum glucose levels in immature rats. Lane RH, etal., Am J Physiol Regul Integr Comp Physiol 2002 Dec;283(6):R1450-60.
9. The high affinity Na+/glucose cotransporter. Re-evaluation of function and distribution of expression. Lee WS, etal., J Biol Chem 1994 Apr 22;269(16):12032-9.
10. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
11. Apical GLUT2 and Cav1.3: regulation of rat intestinal glucose and calcium absorption. Morgan EL, etal., J Physiol. 2007 Apr 15;580(Pt. 2):593-604. Epub 2007 Feb 1.
12. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
13. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
14. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
15. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
16. GOA pipeline RGD automated data pipeline
17. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
18. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
19. Rat renal glucose transporter SGLT1 exhibits zonal distribution and androgen-dependent gender differences. Sabolic I, etal., Am J Physiol Renal Physiol. 2006 Apr;290(4):F913-26. Epub 2005 Oct 4.
20. The glucose transporter families SGLT and GLUT: molecular basis of normal and aberrant function. Scheepers A, etal., JPEN J Parenter Enteral Nutr. 2004 Sep-Oct;28(5):364-71.
21. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
22. The apical localization of SGLT1 glucose transporter is determined by the short amino acid sequence in its N-terminal domain. Suzuki T, etal., Eur J Cell Biol 2001 Dec;80(12):765-74.
23. Glucose/galactose malabsorption caused by a defect in the Na+/glucose cotransporter. Turk E, etal., Nature. 1991 Mar 28;350(6316):354-6.
24. The endogenous CXXC motif governs the cadmium sensitivity of the renal Na+/glucose co-transporter. Xia X, etal., J Am Soc Nephrol. 2005 May;16(5):1257-65. Epub 2005 Apr 13.
Additional References at PubMed
PMID:1702069   PMID:8563765   PMID:8836035   PMID:9214758   PMID:10973981   PMID:10997927   PMID:12773314   PMID:14659592   PMID:14733905   PMID:15333706   PMID:15489334   PMID:15601832  
PMID:15662550   PMID:15677491   PMID:17130520   PMID:17488247   PMID:17673438   PMID:17686765   PMID:17702818   PMID:18154936   PMID:18308853   PMID:18325982   PMID:18524944   PMID:18549898  
PMID:18617558   PMID:19056867   PMID:19095325   PMID:19231582   PMID:19238474   PMID:19541015   PMID:20395849   PMID:20625908   PMID:20841505   PMID:20975661   PMID:20980548   PMID:21148403  
PMID:21433280   PMID:21859816   PMID:22905389   PMID:23249697   PMID:23376485   PMID:23633155   PMID:23975336   PMID:24412219   PMID:24652792   PMID:25652450   PMID:25711084   PMID:25898949  
PMID:26130763   PMID:26316524   PMID:26423860   PMID:26658676   PMID:26902517   PMID:26920054   PMID:26945065   PMID:31828140   PMID:33608832  


Genomics

Comparative Map Data
Slc5a1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81481,778,495 - 81,843,084 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1481,778,348 - 81,846,624 (-)EnsemblGRCr8
mRatBN7.21477,553,990 - 77,618,589 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1477,553,843 - 77,618,547 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1481,996,099 - 82,060,059 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01483,236,643 - 83,300,604 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01479,681,950 - 79,745,920 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01482,910,448 - 82,975,303 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1482,909,981 - 82,975,263 (-)Ensemblrn6Rnor6.0
Rnor_5.01483,595,212 - 83,660,531 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41483,311,232 - 83,370,657 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1476,469,843 - 76,534,501 (-)NCBICelera
RGSC_v3.11483,313,626 - 83,376,968 (-)NCBI
Cytogenetic Map14q21NCBI
SLC5A1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382232,043,261 - 32,113,029 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2232,043,050 - 32,113,029 (+)Ensemblhg38GRCh38
GRCh372232,439,248 - 32,509,016 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362230,769,259 - 30,836,645 (+)NCBIBuild 36Build 36hg18NCBI36
Build 342230,763,812 - 30,831,199NCBI
Celera2216,239,500 - 16,309,474 (+)NCBICelera
Cytogenetic Map22q12.3ENTREZGENE
HuRef2215,394,743 - 15,464,755 (+)NCBIHuRef
CHM1_12232,398,482 - 32,468,466 (+)NCBICHM1_1
T2T-CHM13v2.02232,507,411 - 32,577,165 (+)NCBIT2T-CHM13v2.0
Slc5a1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39533,261,563 - 33,320,043 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl533,261,563 - 33,320,214 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38533,104,219 - 33,162,699 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl533,104,219 - 33,162,870 (+)Ensemblmm10GRCm38
MGSCv37533,446,868 - 33,505,348 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36533,421,091 - 33,479,554 (+)NCBIMGSCv36mm8
Celera530,580,692 - 30,638,639 (+)NCBICelera
Cytogenetic Map5B1NCBI
cM Map517.46NCBI
Slc5a1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554556,158,959 - 6,236,189 (+)Ensembl
ChiLan1.0NW_0049554556,158,773 - 6,236,950 (+)NCBIChiLan1.0ChiLan1.0
SLC5A1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22341,998,754 - 42,069,122 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12244,701,128 - 44,771,587 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02213,070,853 - 13,140,948 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12230,924,169 - 30,992,046 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2230,924,169 - 30,992,046 (+)EnsemblpanPan2panpan1.1
SLC5A1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12624,884,853 - 24,956,190 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2624,884,129 - 24,958,122 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha2624,753,966 - 24,825,294 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.02625,271,492 - 25,342,861 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2625,271,492 - 25,344,793 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12624,970,435 - 25,041,763 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02625,233,313 - 25,304,655 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02625,294,732 - 25,366,070 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
SLC5A1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1448,628,224 - 48,705,841 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11448,566,400 - 48,704,145 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21452,053,314 - 52,149,508 (+)NCBISscrofa10.2Sscrofa10.2susScr3
Sscrofa10.21451,945,530 - 52,000,682 (+)NCBISscrofa10.2Sscrofa10.2susScr3
SLC5A1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11914,924,954 - 14,999,369 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1914,928,160 - 15,002,498 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_023666045111,104,887 - 111,182,726 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Slc5a1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247478,452,616 - 8,540,421 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247478,368,446 - 8,542,573 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Slc5a1
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11171,667,741 - 71,727,304 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Slc5a1
629 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:362
Count of miRNA genes:210
Interacting mature miRNAs:242
Transcripts:ENSRNOT00000024165
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2313089Bss81Bone structure and strength QTL 813.40.0001body length (VT:0001256)body length, nose to rump (CMO:0000079)143802371083023710Rat
9590294Uminl4Urine mineral level QTL 45.660.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)1459848686104848686Rat
1582236Gluco22Glucose level QTL 223.30.0164blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)147764007196755654Rat
2300197Scl59Serum cholesterol level QTL 59blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)1477914838104348525Rat
70214Niddm28Non-insulin dependent diabetes mellitus QTL 284.06blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)143900944484009444Rat
70153Bp59Blood pressure QTL 593.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)147297021087582095Rat
70187Pancm5Pancreatic morphology QTL 516.7pancreas mass (VT:0010144)pancreas weight to body weight ratio (CMO:0000630)143067446985041098Rat
631523Pia13Pristane induced arthritis QTL 133.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1433424686102238540Rat
1582259Gluco23Glucose level QTL 233.10.0008blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1474255551109089856Rat
1582197Gluco27Glucose level QTL 273.40.0006blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)147764007196755654Rat
2313100Bss82Bone structure and strength QTL 8230.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)143802371083023710Rat
634328Hc5Hypercalciuria QTL 52.3urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)1462398852107398852Rat
1582250Gluco26Glucose level QTL 263.30.0009blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1477640071100078267Rat
2317879Alcrsp27Alcohol response QTL 273.30.63response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)1460854936105854936Rat
1641900Alcrsp11Alcohol response QTL 11alcohol metabolism trait (VT:0015089)blood ethanol level (CMO:0000535)1474255551109089856Rat
631839Niddm37Non-insulin dependent diabetes mellitus QTL 373.37blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1411334716100078267Rat
1582255Gluco29Glucose level QTL 293.10.0025blood glucose amount (VT:0000188)absolute change in blood glucose level area under curve (CMO:0002034)147764007196755654Rat
9589034Epfw11Epididymal fat weight QTL 1160.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)1459848686104848686Rat
1582209Gluco20Glucose level QTL 203.80.0005blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)147764007196755654Rat
2313048Bss84Bone structure and strength QTL 843.10.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)143802371083023710Rat
1300136Rf22Renal function QTL 223.9renal blood flow trait (VT:2000006)absolute change in renal vascular resistance (CMO:0001900)144261625899224555Rat
1549834Scl45Serum cholesterol level QTL 455.8blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)146592028399224555Rat
738037Hcas6Hepatocarcinoma susceptibility QTL 62.93liver integrity trait (VT:0010547)liver nonremodeling tumorous lesion volume to total liver volume ratio (CMO:0001464)143941117087582095Rat
2313084Bss83Bone structure and strength QTL 832.90.0001tibia size trait (VT:0100001)tibia midshaft endosteal cross-sectional area (CMO:0001716)143802371083023710Rat

Markers in Region
AU048701  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21477,585,188 - 77,585,431 (+)MAPPERmRatBN7.2
Rnor_6.01482,941,906 - 82,942,146NCBIRnor6.0
Rnor_5.01483,626,833 - 83,627,073UniSTSRnor5.0
RGSC_v3.41483,337,260 - 83,337,500UniSTSRGSC3.4
Celera1476,501,166 - 76,501,406UniSTS
Cytogenetic Map14q21UniSTS
AU048806  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21477,586,711 - 77,586,906 (+)MAPPERmRatBN7.2
Rnor_6.01482,943,427 - 82,943,621NCBIRnor6.0
Rnor_5.01483,628,354 - 83,628,546UniSTSRnor5.0
RGSC_v3.41483,338,781 - 83,338,975UniSTSRGSC3.4
Celera1476,502,687 - 76,502,879UniSTS
Cytogenetic Map14q21UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 2 16 53 59 68 39 42 39 6 204 66 45 81 86 29 4 4

Sequence


Ensembl Acc Id: ENSRNOT00000024165   ⟹   ENSRNOP00000024165
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1481,778,348 - 81,843,042 (-)Ensembl
mRatBN7.2 Ensembl1477,553,843 - 77,618,547 (-)Ensembl
Rnor_6.0 Ensembl1482,909,981 - 82,975,263 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000107808   ⟹   ENSRNOP00000089611
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1481,778,717 - 81,801,110 (-)Ensembl
mRatBN7.2 Ensembl1477,554,212 - 77,576,607 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000113292   ⟹   ENSRNOP00000094831
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1481,778,348 - 81,843,042 (-)Ensembl
mRatBN7.2 Ensembl1477,553,843 - 77,618,547 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000114479   ⟹   ENSRNOP00000094345
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1481,778,348 - 81,798,305 (-)Ensembl
mRatBN7.2 Ensembl1477,553,843 - 77,573,802 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000143373   ⟹   ENSRNOP00000109562
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1481,778,348 - 81,846,624 (-)Ensembl
RefSeq Acc Id: NM_013033   ⟹   NP_037165
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81481,778,495 - 81,843,084 (-)NCBI
mRatBN7.21477,553,990 - 77,618,589 (-)NCBI
Rnor_6.01482,910,448 - 82,975,303 (-)NCBI
Rnor_5.01483,595,212 - 83,660,531 (-)NCBI
RGSC_v3.41483,311,232 - 83,370,657 (-)RGD
Celera1476,469,843 - 76,534,501 (-)RGD
Sequence:
RefSeq Acc Id: NP_037165   ⟸   NM_013033
- UniProtKB: P97787 (UniProtKB/Swiss-Prot),   P53790 (UniProtKB/Swiss-Prot),   A6IK70 (UniProtKB/TrEMBL),   A6IK69 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000024165   ⟸   ENSRNOT00000024165
Ensembl Acc Id: ENSRNOP00000094345   ⟸   ENSRNOT00000114479
Ensembl Acc Id: ENSRNOP00000089611   ⟸   ENSRNOT00000107808
Ensembl Acc Id: ENSRNOP00000094831   ⟸   ENSRNOT00000113292
Ensembl Acc Id: ENSRNOP00000109562   ⟸   ENSRNOT00000143373

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P53790-F1-model_v2 AlphaFold P53790 1-665 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13699414
Promoter ID:EPDNEW_R9939
Type:single initiation site
Name:Slc5a1_1
Description:solute carrier family 5 member 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01482,975,242 - 82,975,302EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3713 AgrOrtholog
BioCyc Gene G2FUF-15252 BioCyc
Ensembl Genes ENSRNOG00000017775 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000024165 ENTREZGENE
  ENSRNOT00000024165.7 UniProtKB/Swiss-Prot
Gene3D-CATH 1.20.1730.10 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7129017 IMAGE-MGC_LOAD
InterPro Na/Glc_symporter_sf UniProtKB/Swiss-Prot
  Na/solute_symporter UniProtKB/Swiss-Prot
  Na/solute_symporter_CS UniProtKB/Swiss-Prot
KEGG Report rno:25552 UniProtKB/Swiss-Prot
MGC_CLONE MGC:93553 IMAGE-MGC_LOAD
NCBI Gene 25552 ENTREZGENE
PANTHER SODIUM/GLUCOSE COTRANSPORTER 1 UniProtKB/Swiss-Prot
  SOLUTE CARRIER FAMILY 5 UniProtKB/Swiss-Prot
Pfam SSF UniProtKB/Swiss-Prot
PhenoGen Slc5a1 PhenoGen
PROSITE NA_SOLUT_SYMP_1 UniProtKB/Swiss-Prot
  NA_SOLUT_SYMP_2 UniProtKB/Swiss-Prot
  NA_SOLUT_SYMP_3 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000017775 RatGTEx
UniProt A0A125RL27_RAT UniProtKB/TrEMBL
  A0A8I6AKD1_RAT UniProtKB/TrEMBL
  A0A8I6ALY2_RAT UniProtKB/TrEMBL
  A0ABK0M3Z7_RAT UniProtKB/TrEMBL
  A6IK69 ENTREZGENE, UniProtKB/TrEMBL
  A6IK70 ENTREZGENE, UniProtKB/TrEMBL
  P53790 ENTREZGENE
  P97787 ENTREZGENE
  SC5A1_RAT UniProtKB/Swiss-Prot
UniProt Secondary P97787 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-03-09 Slc5a1  solute carrier family 5 member 1  Slc5a1  solute carrier family 5 (sodium/glucose cotransporter), member 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-09-10 Slc5a1  solute carrier family 5 (sodium/glucose cotransporter), member 1  Slc5a1  solute carrier family 5, member 1  Name updated 1299863 APPROVED
2004-09-10 Slc5a1  solute carrier family 5 (sodium/glucose cotransporter), member 1    solute carrier family 5, member 1  Name updated 1299863 APPROVED
2003-04-09 Slc5a1  solute carrier family 5, member 1  Slc5a1  Solute carrier family 5, member alpha 1 (Na+/glucose cotransporter)  Name updated 629478 APPROVED
2003-04-09 Slc5a1  solute carrier family 5, member 1    Solute carrier family 5, member alpha 1 (Na+/glucose cotransporter)  Name updated 629478 APPROVED
2002-06-10 Slc5a1  Solute carrier family 5, member alpha 1 (Na+/glucose cotransporter)      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_cellular_localization localized to apical plasma membrane in epithelial cells of small intestine and kidney; amino acid Asp28 is important for localization to the apical plasma membrane 730194
gene_expression expressed in kidney, small intestine, liver and lung 730007
gene_function transports sodium-dependent transport of glucose 730007
gene_function transports flavinoid glucosides in small intestine 1299033
gene_homology 86-87% identical to rabbit, pig and human homologs 730007
gene_process involved in reabsorption of D-glucose in kidney 730007
gene_protein 665 amino acid protein 730007