Imported Disease Annotations - CTDObject Symbol | Species | Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | Slc4a3 | Rat | heart disease | | ISO | SLC4A3 (Homo sapiens) | 11554173 | CTD Direct Evidence: marker/mechanism | CTD | PMID:16844662 | | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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Imported Disease Annotations - CTDObject Symbol | Species | Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | Slc4a3 | Rat | heart disease | | ISO | SLC4A3 (Homo sapiens) | 11554173 | CTD Direct Evidence: marker/mechanism | CTD | PMID:16844662 | | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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| # | Reference Title | Reference Citation |
| 1. | Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. | Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27. |
| 2. | Rat ISS GO annotations from GOA human gene data--August 2006 | GOA data from the GO Consortium |
| 3. | cDNA cloning and tissue distribution of mRNAs for two proteins that are related to the band 3 Cl-/HCO3- exchanger. | Kudrycki KE, etal., J Biol Chem 1990 Jan 5;265(1):462-71. |
| 4. | Rat ISS GO annotations from MGI mouse gene data--August 2006 | MGD data from the GO Consortium |
| 5. | Interactions of transmembrane carbonic anhydrase, CAIX, with bicarbonate transporters. | Morgan PE, etal., Am J Physiol Cell Physiol. 2007 Aug;293(2):C738-48. Epub 2007 Jul 25. |
| 6. | Electronic Transfer of LocusLink and RefSeq Data | NCBI rat LocusLink and RefSeq merged data July 26, 2002 |
| 7. | GOA pipeline | RGD automated data pipeline |
| 8. | ClinVar Automated Import and Annotation Pipeline | RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations |
| 9. | Data Import for Chemical-Gene Interactions | RGD automated import pipeline for gene-chemical interactions |
| 10. | Chromosomal mapping of the rat Slc4a family of anion exchanger genes, Ae1, Ae2, and Ae3. | Simon JS, etal., Mamm Genome 1996 May;7(5):380-2. |
| 11. | Transport activity of AE3 chloride/bicarbonate anion-exchange proteins and their regulation by intracellular pH. | Sterling D and Casey JR, Biochem J. 1999 Nov 15;344 Pt 1(Pt 1):221-9. |
| PMID:2686841 | PMID:21608017 | PMID:22693949 | PMID:22871113 | PMID:29167417 |
| Slc4a3 (Rattus norvegicus - Norway rat) |
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| SLC4A3 (Homo sapiens - human) |
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| Slc4a3 (Mus musculus - house mouse) |
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| Slc4a3 (Chinchilla lanigera - long-tailed chinchilla) |
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| SLC4A3 (Pan paniscus - bonobo/pygmy chimpanzee) |
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| SLC4A3 (Canis lupus familiaris - dog) |
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| Slc4a3 (Ictidomys tridecemlineatus - thirteen-lined ground squirrel) |
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| SLC4A3 (Sus scrofa - pig) |
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| SLC4A3 (Chlorocebus sabaeus - green monkey) |
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| Slc4a3 (Heterocephalus glaber - naked mole-rat) |
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| Slc4a3 (Rattus rattus - black rat) |
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Variants in Slc4a3
56 total Variants
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| The detailed report is available here: | ![]() | Full Report | ![]() | CSV | ![]() | TAB | ![]() | Printer |
miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/). For more information about miRGate, see PMID:25858286 or access the full paper here. |
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| The following QTLs overlap with this region. | ![]() | Full Report | ![]() | CSV | ![]() | TAB | ![]() | Printer | ![]() | Gviewer |
| D9Bro1 |
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| D9Mco24 |
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| RH144096 |
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alimentary part of gastrointestinal system
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appendage
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circulatory system
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ectoderm
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endocrine system
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endoderm
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exocrine system
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hemolymphoid system
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hepatobiliary system
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integumental system
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mesenchyme
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mesoderm
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musculoskeletal system
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nervous system
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renal system
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reproductive system
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respiratory system
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sensory system
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visual system
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| 16 | 12 | 67 | 161 | 91 | 90 | 59 | 38 | 59 | 6 | 302 | 138 | 11 | 140 | 81 | 92 | 31 | 17 | 17 |
| RefSeq Transcripts | NM_017049 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles |
| XM_006245149 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
| XM_017596276 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
| XM_017596277 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
| XM_017596278 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
| XM_017596279 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
| XM_017596280 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
| XM_017596281 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
| XM_039083028 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
| XM_039083030 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
| XM_063266648 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
| XM_063266649 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
| XM_063266650 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
| XM_063266651 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
| GenBank Nucleotide | AC112361 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles |
| CH474004 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
| J05167 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
| JAXUCZ010000009 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles |
| Ensembl Acc Id: | ENSRNOT00000027337 ⟹ ENSRNOP00000027337 | ||||||||||||||||
| Type: | CODING | ||||||||||||||||
| Position: |
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| RefSeq Acc Id: | NM_017049 ⟹ NP_058745 | ||||||||||||||||||||||||||||
| RefSeq Status: | PROVISIONAL | ||||||||||||||||||||||||||||
| Type: | CODING | ||||||||||||||||||||||||||||
| Position: |
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| Sequence: |
| RefSeq Acc Id: | XM_006245149 ⟹ XP_006245211 | ||||||||||||||||||||
| Type: | CODING | ||||||||||||||||||||
| Position: |
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| Sequence: |
| RefSeq Acc Id: | XM_017596276 ⟹ XP_017451765 | ||||||||||||||||
| Type: | CODING | ||||||||||||||||
| Position: |
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| Sequence: |
| RefSeq Acc Id: | XM_017596277 ⟹ XP_017451766 | ||||||||||||||||
| Type: | CODING | ||||||||||||||||
| Position: |
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| Sequence: |
| RefSeq Acc Id: | XM_017596279 ⟹ XP_017451768 | ||||||||||||||||
| Type: | CODING | ||||||||||||||||
| Position: |
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| Sequence: |
| RefSeq Acc Id: | XM_017596280 ⟹ XP_017451769 | ||||||||||||||||
| Type: | CODING | ||||||||||||||||
| Position: |
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| Sequence: |
| RefSeq Acc Id: | XM_039083028 ⟹ XP_038938956 | ||||||||||||
| Type: | CODING | ||||||||||||
| Position: |
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| RefSeq Acc Id: | XM_039083030 ⟹ XP_038938958 | ||||||||||||
| Type: | CODING | ||||||||||||
| Position: |
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| RefSeq Acc Id: | XM_063266648 ⟹ XP_063122718 | ||||||||
| Type: | CODING | ||||||||
| Position: |
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| RefSeq Acc Id: | XM_063266649 ⟹ XP_063122719 | ||||||||
| Type: | CODING | ||||||||
| Position: |
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| RefSeq Acc Id: | XM_063266650 ⟹ XP_063122720 | ||||||||
| Type: | CODING | ||||||||
| Position: |
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| RefSeq Acc Id: | XM_063266651 ⟹ XP_063122721 | ||||||||
| Type: | CODING | ||||||||
| Position: |
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| Protein RefSeqs | NP_058745 | (Get FASTA) | NCBI Sequence Viewer |
| XP_006245211 | (Get FASTA) | NCBI Sequence Viewer | |
| XP_017451765 | (Get FASTA) | NCBI Sequence Viewer | |
| XP_017451766 | (Get FASTA) | NCBI Sequence Viewer | |
| XP_017451768 | (Get FASTA) | NCBI Sequence Viewer | |
| XP_017451769 | (Get FASTA) | NCBI Sequence Viewer | |
| XP_038938956 | (Get FASTA) | NCBI Sequence Viewer | |
| XP_038938958 | (Get FASTA) | NCBI Sequence Viewer | |
| XP_063122718 | (Get FASTA) | NCBI Sequence Viewer | |
| XP_063122719 | (Get FASTA) | NCBI Sequence Viewer | |
| XP_063122720 | (Get FASTA) | NCBI Sequence Viewer | |
| XP_063122721 | (Get FASTA) | NCBI Sequence Viewer | |
| GenBank Protein | AAA40798 | (Get FASTA) | NCBI Sequence Viewer |
| EDL75455 | (Get FASTA) | NCBI Sequence Viewer | |
| EDL75456 | (Get FASTA) | NCBI Sequence Viewer | |
| Ensembl Protein | ENSRNOP00000027337 | ||
| GenBank Protein | P23348 | (Get FASTA) | NCBI Sequence Viewer |
| RefSeq Acc Id: | NP_058745 ⟸ NM_017049 |
| - UniProtKB: | P23348 (UniProtKB/Swiss-Prot), G3V8P8 (UniProtKB/TrEMBL), A6JW47 (UniProtKB/TrEMBL) |
| - Sequence: |
| RefSeq Acc Id: | XP_006245211 ⟸ XM_006245149 |
| - Peptide Label: | isoform X3 |
| - Sequence: |
| RefSeq Acc Id: | XP_017451769 ⟸ XM_017596280 |
| - Peptide Label: | isoform X1 |
| - UniProtKB: | P23348 (UniProtKB/Swiss-Prot), G3V8P8 (UniProtKB/TrEMBL), A6JW47 (UniProtKB/TrEMBL) |
| - Sequence: |
| RefSeq Acc Id: | XP_017451766 ⟸ XM_017596277 |
| - Peptide Label: | isoform X1 |
| - UniProtKB: | P23348 (UniProtKB/Swiss-Prot), G3V8P8 (UniProtKB/TrEMBL), A6JW47 (UniProtKB/TrEMBL) |
| - Sequence: |
| RefSeq Acc Id: | XP_017451768 ⟸ XM_017596279 |
| - Peptide Label: | isoform X1 |
| - UniProtKB: | P23348 (UniProtKB/Swiss-Prot), G3V8P8 (UniProtKB/TrEMBL), A6JW47 (UniProtKB/TrEMBL) |
| - Sequence: |
| RefSeq Acc Id: | XP_017451765 ⟸ XM_017596276 |
| - Peptide Label: | isoform X1 |
| - UniProtKB: | P23348 (UniProtKB/Swiss-Prot), G3V8P8 (UniProtKB/TrEMBL), A6JW47 (UniProtKB/TrEMBL) |
| - Sequence: |
| Ensembl Acc Id: | ENSRNOP00000027337 ⟸ ENSRNOT00000027337 |
| RefSeq Acc Id: | XP_038938956 ⟸ XM_039083028 |
| - Peptide Label: | isoform X2 |
| - UniProtKB: | P23348 (UniProtKB/Swiss-Prot) |
| RefSeq Acc Id: | XP_038938958 ⟸ XM_039083030 |
| - Peptide Label: | isoform X6 |
| RefSeq Acc Id: | XP_063122718 ⟸ XM_063266648 |
| - Peptide Label: | isoform X1 |
| - UniProtKB: | P23348 (UniProtKB/Swiss-Prot), A6JW47 (UniProtKB/TrEMBL), G3V8P8 (UniProtKB/TrEMBL) |
| RefSeq Acc Id: | XP_063122719 ⟸ XM_063266649 |
| - Peptide Label: | isoform X4 |
| RefSeq Acc Id: | XP_063122720 ⟸ XM_063266650 |
| - Peptide Label: | isoform X4 |
| RefSeq Acc Id: | XP_063122721 ⟸ XM_063266651 |
| - Peptide Label: | isoform X5 |
| Name | Modeler | Protein Id | AA Range | Protein Structure |
| AF-P23348-F1-model_v2 | AlphaFold | P23348 | 1-1227 | view protein structure |
| eQTL | View at Phenogen | |
| WGCNA | View at Phenogen | |
| Tissue/Strain Expression | View at Phenogen |
| Database | Acc Id | Source(s) |
| AGR Gene | RGD:3712 | AgrOrtholog |
| BioCyc Gene | G2FUF-27057 | BioCyc |
| Ensembl Genes | ENSRNOG00000020138 | Ensembl, ENTREZGENE |
| Ensembl Transcript | ENSRNOT00000027337 | ENTREZGENE |
| Gene3D-CATH | Helical hairpin bin | UniProtKB/Swiss-Prot |
| Mannitol-specific EII, Chain A | UniProtKB/Swiss-Prot | |
| InterPro | Anion_exchange | UniProtKB/Swiss-Prot |
| Anion_exchange_3 | UniProtKB/Swiss-Prot | |
| Anion_exchange_CS | UniProtKB/Swiss-Prot | |
| Band3_cytoplasmic_dom | UniProtKB/Swiss-Prot | |
| HCO3_transpt_C | UniProtKB/Swiss-Prot | |
| HCO3_transpt_euk | UniProtKB/Swiss-Prot | |
| PTrfase/Anion_transptr | UniProtKB/Swiss-Prot | |
| KEGG Report | rno:24781 | UniProtKB/Swiss-Prot |
| NCBI Gene | 24781 | ENTREZGENE |
| PANTHER | PTHR11453 | UniProtKB/Swiss-Prot |
| PTHR11453:SF15 | UniProtKB/Swiss-Prot | |
| Pfam | Band_3_cyto | UniProtKB/Swiss-Prot |
| HCO3_cotransp | UniProtKB/Swiss-Prot | |
| PhenoGen | Slc4a3 | PhenoGen |
| PRINTS | ANIONEXCHNGR | UniProtKB/Swiss-Prot |
| ANIONEXHNGR3 | UniProtKB/Swiss-Prot | |
| HCO3TRNSPORT | UniProtKB/Swiss-Prot | |
| PROSITE | ANION_EXCHANGER_1 | UniProtKB/Swiss-Prot |
| ANION_EXCHANGER_2 | UniProtKB/Swiss-Prot | |
| RatGTEx | ENSRNOG00000020138 | RatGTEx |
| Superfamily-SCOP | SSF55804 | UniProtKB/Swiss-Prot |
| UniProt | A6JW47 | ENTREZGENE, UniProtKB/TrEMBL |
| B3A3_RAT | UniProtKB/Swiss-Prot | |
| G3V8P8 | ENTREZGENE, UniProtKB/TrEMBL | |
| P23348 | ENTREZGENE |
| Date | Current Symbol | Current Name | Previous Symbol | Previous Name | Description | Reference | Status |
|---|---|---|---|---|---|---|---|
| 2016-02-24 | Slc4a3 | solute carrier family 4 member 3 | Slc4a3 | solute carrier family 4 (anion exchanger), member 3 | Nomenclature updated to reflect human and mouse nomenclature | 1299863 | APPROVED |
| 2008-02-15 | Slc4a3 | solute carrier family 4 (anion exchanger), member 3 | Slc4a3 | solute carrier family 4, member 3 | Nomenclature updated to reflect human and mouse nomenclature | 1299863 | APPROVED |
| 2003-04-09 | Slc4a3 | solute carrier family 4, member 3 | Solute carrier family 4, member 3, anion exchange protein 3 | Name updated | 629478 | APPROVED | |
| 2002-06-10 | Slc4a3 | Solute carrier family 4, member 3, anion exchange protein 3 | Symbol and Name status set to approved | 70586 | APPROVED |
| Note Type | Note | Reference |
|---|---|---|
| gene_expression | mRNA expressed mostly in the heart and forestomach | 729955 |
| gene_mapping | segregates on chr 4 with blood pressure in recombinant inbred rats derived by crossing SHR and BN | 1342444 |
| gene_protein | predicted protein consists of 1227 aa residues and masses 135.4 kDa | 729955 |