Slc4a3 (solute carrier family 4 member 3) - Rat Genome Database

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Pathways
Gene: Slc4a3 (solute carrier family 4 member 3) Rattus norvegicus
Analyze
Symbol: Slc4a3
Name: solute carrier family 4 member 3
RGD ID: 3712
Description: Enables chloride:bicarbonate antiporter activity and enzyme binding activity. Predicted to be involved in several processes, including bicarbonate transport; regulation of cardiac muscle cell action potential; and regulation of pH. Predicted to act upstream of or within cardiac conduction. Located in plasma membrane. Orthologous to human SLC4A3 (solute carrier family 4 member 3); INTERACTS WITH 1-naphthyl isothiocyanate; 2,3,7,8-tetrachlorodibenzodioxine; acetamide.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: AE 3; Ae3; Aep3; anion exchange protein 3; anion exchanger 3; B3RP-3; band 3-related protein 3; neuronal band 3-like protein; solute carrier family 4 (anion exchanger), member 3; Solute carrier family 4 member 3 anion exchange protein 3; solute carrier family 4, member 3; Solute carrier family 4, member 3, anion exchange protein 3
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8984,484,749 - 84,497,746 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl984,485,085 - 84,497,738 (+)EnsemblGRCr8
mRatBN7.2977,036,243 - 77,053,940 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl977,037,016 - 77,049,105 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx985,481,242 - 85,493,343 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0990,610,117 - 90,622,218 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0988,996,301 - 89,008,402 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0982,742,207 - 82,755,119 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl982,741,920 - 82,755,153 (+)Ensemblrn6Rnor6.0
Rnor_5.0982,512,289 - 82,524,380 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4974,823,769 - 74,835,860 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera974,606,698 - 74,618,789 (+)NCBICelera
RGSC_v3.1974,983,838 - 74,995,930 (+)NCBI
Cytogenetic Map9q33NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
external side of plasma membrane  (IEA,ISO)
membrane  (IEA)
plasma membrane  (IBA,IDA,IEA,ISO)

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. cDNA cloning and tissue distribution of mRNAs for two proteins that are related to the band 3 Cl-/HCO3- exchanger. Kudrycki KE, etal., J Biol Chem 1990 Jan 5;265(1):462-71.
4. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
5. Interactions of transmembrane carbonic anhydrase, CAIX, with bicarbonate transporters. Morgan PE, etal., Am J Physiol Cell Physiol. 2007 Aug;293(2):C738-48. Epub 2007 Jul 25.
6. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
7. GOA pipeline RGD automated data pipeline
8. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
9. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
10. Chromosomal mapping of the rat Slc4a family of anion exchanger genes, Ae1, Ae2, and Ae3. Simon JS, etal., Mamm Genome 1996 May;7(5):380-2.
11. Transport activity of AE3 chloride/bicarbonate anion-exchange proteins and their regulation by intracellular pH. Sterling D and Casey JR, Biochem J. 1999 Nov 15;344 Pt 1(Pt 1):221-9.
Additional References at PubMed
PMID:2686841   PMID:21608017   PMID:22693949   PMID:22871113   PMID:29167417  


Genomics

Comparative Map Data
Slc4a3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8984,484,749 - 84,497,746 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl984,485,085 - 84,497,738 (+)EnsemblGRCr8
mRatBN7.2977,036,243 - 77,053,940 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl977,037,016 - 77,049,105 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx985,481,242 - 85,493,343 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0990,610,117 - 90,622,218 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0988,996,301 - 89,008,402 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0982,742,207 - 82,755,119 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl982,741,920 - 82,755,153 (+)Ensemblrn6Rnor6.0
Rnor_5.0982,512,289 - 82,524,380 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4974,823,769 - 74,835,860 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera974,606,698 - 74,618,789 (+)NCBICelera
RGSC_v3.1974,983,838 - 74,995,930 (+)NCBI
Cytogenetic Map9q33NCBI
SLC4A3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382219,627,630 - 219,641,971 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2219,627,011 - 219,641,980 (+)Ensemblhg38GRCh38
GRCh372220,492,352 - 220,506,693 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362220,200,536 - 220,214,946 (+)NCBIBuild 36Build 36hg18NCBI36
Build 342220,317,791 - 220,332,197NCBI
Celera2214,262,260 - 214,276,669 (+)NCBICelera
Cytogenetic Map2q35NCBI
HuRef2212,345,224 - 212,359,627 (+)NCBIHuRef
CHM1_12220,498,113 - 220,512,522 (+)NCBICHM1_1
T2T-CHM13v2.02220,112,359 - 220,126,699 (+)NCBIT2T-CHM13v2.0
Slc4a3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39175,522,688 - 75,536,075 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl175,522,910 - 75,538,816 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38175,546,044 - 75,559,431 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl175,546,266 - 75,562,172 (+)Ensemblmm10GRCm38
MGSCv37175,542,841 - 75,556,006 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36175,429,444 - 75,442,227 (+)NCBIMGSCv36mm8
Celera176,037,295 - 76,050,423 (+)NCBICelera
Cytogenetic Map1C4NCBI
cM Map139.16NCBI
Slc4a3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545313,843,556 - 13,859,705 (-)Ensembl
ChiLan1.0NW_00495545313,846,444 - 13,859,707 (-)NCBIChiLan1.0ChiLan1.0
SLC4A3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v213122,257,661 - 122,272,044 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12B122,272,628 - 122,287,010 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02B106,884,750 - 106,899,143 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12B225,475,148 - 225,489,189 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B225,475,148 - 225,489,189 (+)EnsemblpanPan2panpan1.1
SLC4A3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13726,136,589 - 26,149,312 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3726,136,412 - 26,149,312 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha3726,962,037 - 26,974,762 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.03726,151,769 - 26,167,414 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3726,151,769 - 26,165,924 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13726,055,607 - 26,068,323 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03725,991,659 - 26,004,366 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03726,012,382 - 26,025,125 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Slc4a3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405303175,650,060 - 175,662,989 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365691,992,814 - 2,008,800 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365691,992,850 - 2,005,770 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SLC4A3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl15121,630,316 - 121,643,539 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.115121,629,794 - 121,643,554 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
SLC4A3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.110105,528,845 - 105,543,657 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl10105,529,093 - 105,543,405 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366604093,858,750 - 93,872,999 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Slc4a3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248235,439,336 - 5,453,801 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046248235,440,213 - 5,453,683 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Slc4a3
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v14148,898,439 - 148,911,436 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Slc4a3
56 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:51
Count of miRNA genes:41
Interacting mature miRNAs:49
Transcripts:ENSRNOT00000027337
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631656Bp108Blood pressure QTL 1085.970.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)956047863101047863Rat
7411571Bw138Body weight QTL 13814.30.001body mass (VT:0001259)body weight gain (CMO:0000420)94002992585029925Rat
1582203Gluco19Glucose level QTL 193.30.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)963376862108376862Rat
724515Uae16Urinary albumin excretion QTL 168urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)965657365108376720Rat
61352Bp34Blood pressure QTL 345arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)98216882386720295Rat
8662828Vetf6Vascular elastic tissue fragility QTL 63.9artery integrity trait (VT:0010639)patent ductus arteriosus score (CMO:0002566)94445825699506504Rat
1598834Memor11Memory QTL 112.5exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)94445825685262605Rat
70218Cm28Cardiac mass QTL 288.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)94172029586720295Rat
724544Uae9Urinary albumin excretion QTL 94.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)964220169109220169Rat
1578760Cm53Cardiac mass QTL 533.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)964220169109220169Rat
2290450Scl57Serum cholesterol level QTL 574.15blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)944458256121768150Rat
1581580Uae34Urinary albumin excretion QTL 34urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)964220169109220169Rat
1300134Bp185Blood pressure QTL 1853.73arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)968875497121768150Rat
1354626Bvd1Brain ventricular dilatation QTL 13.730.001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)983161999118999486Rat
731164Uae25Urinary albumin excretion QTL 253.50.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)948718864108376862Rat
7411656Foco26Food consumption QTL 269.80.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)94002992585029925Rat
1578757Pur6Proteinuria QTL 63.30.005urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)964220169109220169Rat
4889943Bss90Bone structure and strength QTL 904.1tibia area (VT:1000281)tibia-fibula cortical bone endosteal cross-sectional area (CMO:0001722)95450650499506504Rat

Markers in Region
D9Bro1  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr8984,474,983 - 84,475,093 (+)Marker Load Pipeline
mRatBN7.2977,026,343 - 77,026,453 (+)MAPPERmRatBN7.2
Rnor_6.0982,732,357 - 82,732,466NCBIRnor6.0
Rnor_5.0982,501,618 - 82,501,727UniSTSRnor5.0
RGSC_v3.4974,813,097 - 74,813,207RGDRGSC3.4
RGSC_v3.4974,813,098 - 74,813,207UniSTSRGSC3.4
RGSC_v3.1974,973,168 - 74,973,277RGD
RH 3.4 Map9757.3UniSTS
RH 3.4 Map9757.3RGD
Cytogenetic Map9q34UniSTS
Cytogenetic Map9q33UniSTS
D9Mco24  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2977,044,883 - 77,045,128 (+)MAPPERmRatBN7.2
Rnor_6.0982,750,896 - 82,751,142NCBIRnor6.0
Rnor_5.0982,520,157 - 82,520,403UniSTSRnor5.0
RGSC_v3.4974,831,637 - 74,831,883UniSTSRGSC3.4
Celera974,614,566 - 74,614,812UniSTS
Cytogenetic Map9q34UniSTS
RH144096  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2977,047,808 - 77,048,901 (+)MAPPERmRatBN7.2
Rnor_6.0982,753,823 - 82,754,915NCBIRnor6.0
Rnor_5.0982,523,084 - 82,524,176UniSTSRnor5.0
RGSC_v3.4974,834,564 - 74,835,656UniSTSRGSC3.4
Celera974,617,493 - 74,618,585UniSTS
RH 3.4 Map9766.3UniSTS
Cytogenetic Map9q34UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 161 91 90 59 38 59 6 302 138 11 140 81 92 31 17 17

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_017049 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006245149 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017596276 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017596277 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017596278 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017596279 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017596280 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017596281 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039083028 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039083030 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063266648 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063266649 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063266650 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063266651 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC112361 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH474004 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  J05167 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000009 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000027337   ⟹   ENSRNOP00000027337
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl984,485,085 - 84,497,738 (+)Ensembl
mRatBN7.2 Ensembl977,037,016 - 77,049,105 (+)Ensembl
Rnor_6.0 Ensembl982,741,920 - 82,755,153 (+)Ensembl
RefSeq Acc Id: NM_017049   ⟹   NP_058745
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8984,485,655 - 84,497,746 (+)NCBI
mRatBN7.2977,037,016 - 77,049,105 (+)NCBI
Rnor_6.0982,743,028 - 82,755,119 (+)NCBI
Rnor_5.0982,512,289 - 82,524,380 (+)NCBI
RGSC_v3.4974,823,769 - 74,835,860 (+)RGD
Celera974,606,698 - 74,618,789 (+)RGD
Sequence:
RefSeq Acc Id: XM_006245149   ⟹   XP_006245211
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8984,488,351 - 84,497,746 (+)NCBI
mRatBN7.2977,039,690 - 77,053,940 (+)NCBI
Rnor_6.0982,745,232 - 82,755,119 (+)NCBI
Rnor_5.0982,512,289 - 82,524,380 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017596276   ⟹   XP_017451765
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8984,485,232 - 84,497,746 (+)NCBI
mRatBN7.2977,036,595 - 77,053,940 (+)NCBI
Rnor_6.0982,742,591 - 82,755,119 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017596277   ⟹   XP_017451766
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8984,484,880 - 84,497,746 (+)NCBI
mRatBN7.2977,036,243 - 77,053,940 (+)NCBI
Rnor_6.0982,742,207 - 82,755,119 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017596279   ⟹   XP_017451768
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8984,484,749 - 84,497,746 (+)NCBI
mRatBN7.2977,036,243 - 77,053,940 (+)NCBI
Rnor_6.0982,742,207 - 82,755,119 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017596280   ⟹   XP_017451769
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8984,484,880 - 84,497,746 (+)NCBI
mRatBN7.2977,036,243 - 77,053,940 (+)NCBI
Rnor_6.0982,742,207 - 82,755,119 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039083028   ⟹   XP_038938956
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8984,486,051 - 84,497,746 (+)NCBI
mRatBN7.2977,037,415 - 77,053,940 (+)NCBI
RefSeq Acc Id: XM_039083030   ⟹   XP_038938958
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8984,490,425 - 84,497,746 (+)NCBI
mRatBN7.2977,041,785 - 77,053,940 (+)NCBI
RefSeq Acc Id: XM_063266648   ⟹   XP_063122718
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8984,485,458 - 84,497,746 (+)NCBI
RefSeq Acc Id: XM_063266649   ⟹   XP_063122719
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8984,486,051 - 84,497,746 (+)NCBI
RefSeq Acc Id: XM_063266650   ⟹   XP_063122720
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8984,486,084 - 84,497,746 (+)NCBI
RefSeq Acc Id: XM_063266651   ⟹   XP_063122721
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8984,490,406 - 84,497,746 (+)NCBI
RefSeq Acc Id: NP_058745   ⟸   NM_017049
- UniProtKB: P23348 (UniProtKB/Swiss-Prot),   G3V8P8 (UniProtKB/TrEMBL),   A6JW47 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006245211   ⟸   XM_006245149
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_017451769   ⟸   XM_017596280
- Peptide Label: isoform X1
- UniProtKB: P23348 (UniProtKB/Swiss-Prot),   G3V8P8 (UniProtKB/TrEMBL),   A6JW47 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017451766   ⟸   XM_017596277
- Peptide Label: isoform X1
- UniProtKB: P23348 (UniProtKB/Swiss-Prot),   G3V8P8 (UniProtKB/TrEMBL),   A6JW47 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017451768   ⟸   XM_017596279
- Peptide Label: isoform X1
- UniProtKB: P23348 (UniProtKB/Swiss-Prot),   G3V8P8 (UniProtKB/TrEMBL),   A6JW47 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017451765   ⟸   XM_017596276
- Peptide Label: isoform X1
- UniProtKB: P23348 (UniProtKB/Swiss-Prot),   G3V8P8 (UniProtKB/TrEMBL),   A6JW47 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000027337   ⟸   ENSRNOT00000027337
RefSeq Acc Id: XP_038938956   ⟸   XM_039083028
- Peptide Label: isoform X2
- UniProtKB: P23348 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_038938958   ⟸   XM_039083030
- Peptide Label: isoform X6
RefSeq Acc Id: XP_063122718   ⟸   XM_063266648
- Peptide Label: isoform X1
- UniProtKB: P23348 (UniProtKB/Swiss-Prot),   A6JW47 (UniProtKB/TrEMBL),   G3V8P8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063122719   ⟸   XM_063266649
- Peptide Label: isoform X4
RefSeq Acc Id: XP_063122720   ⟸   XM_063266650
- Peptide Label: isoform X4
RefSeq Acc Id: XP_063122721   ⟸   XM_063266651
- Peptide Label: isoform X5
Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P23348-F1-model_v2 AlphaFold P23348 1-1227 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3712 AgrOrtholog
BioCyc Gene G2FUF-27057 BioCyc
Ensembl Genes ENSRNOG00000020138 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000027337 ENTREZGENE
Gene3D-CATH Helical hairpin bin UniProtKB/Swiss-Prot
  Mannitol-specific EII, Chain A UniProtKB/Swiss-Prot
InterPro Anion_exchange UniProtKB/Swiss-Prot
  Anion_exchange_3 UniProtKB/Swiss-Prot
  Anion_exchange_CS UniProtKB/Swiss-Prot
  Band3_cytoplasmic_dom UniProtKB/Swiss-Prot
  HCO3_transpt_C UniProtKB/Swiss-Prot
  HCO3_transpt_euk UniProtKB/Swiss-Prot
  PTrfase/Anion_transptr UniProtKB/Swiss-Prot
KEGG Report rno:24781 UniProtKB/Swiss-Prot
NCBI Gene 24781 ENTREZGENE
PANTHER PTHR11453 UniProtKB/Swiss-Prot
  PTHR11453:SF15 UniProtKB/Swiss-Prot
Pfam Band_3_cyto UniProtKB/Swiss-Prot
  HCO3_cotransp UniProtKB/Swiss-Prot
PhenoGen Slc4a3 PhenoGen
PRINTS ANIONEXCHNGR UniProtKB/Swiss-Prot
  ANIONEXHNGR3 UniProtKB/Swiss-Prot
  HCO3TRNSPORT UniProtKB/Swiss-Prot
PROSITE ANION_EXCHANGER_1 UniProtKB/Swiss-Prot
  ANION_EXCHANGER_2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000020138 RatGTEx
Superfamily-SCOP SSF55804 UniProtKB/Swiss-Prot
UniProt A6JW47 ENTREZGENE, UniProtKB/TrEMBL
  B3A3_RAT UniProtKB/Swiss-Prot
  G3V8P8 ENTREZGENE, UniProtKB/TrEMBL
  P23348 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-24 Slc4a3  solute carrier family 4 member 3  Slc4a3  solute carrier family 4 (anion exchanger), member 3  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-02-15 Slc4a3  solute carrier family 4 (anion exchanger), member 3  Slc4a3  solute carrier family 4, member 3  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2003-04-09 Slc4a3  solute carrier family 4, member 3    Solute carrier family 4, member 3, anion exchange protein 3  Name updated 629478 APPROVED
2002-06-10 Slc4a3  Solute carrier family 4, member 3, anion exchange protein 3      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression mRNA expressed mostly in the heart and forestomach 729955
gene_mapping segregates on chr 4 with blood pressure in recombinant inbred rats derived by crossing SHR and BN 1342444
gene_protein predicted protein consists of 1227 aa residues and masses 135.4 kDa 729955