Slco1a1 (solute carrier organic anion transporter family, member 1a1) - Rat Genome Database

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Gene: Slco1a1 (solute carrier organic anion transporter family, member 1a1) Rattus norvegicus
Analyze
No known orthologs.
Symbol: Slco1a1
Name: solute carrier organic anion transporter family, member 1a1
RGD ID: 3700
Description: Enables organic anion transmembrane transporter activity. Involved in organic anion transport and response to testosterone. Predicted to be located in plasma membrane. Predicted to be active in basolateral plasma membrane. Biomarker of Dubin-Johnson syndrome and primary biliary cholangitis. Orthologous to human SLCO1A2 (solute carrier organic anion transporter family member 1A2); PARTICIPATES IN multispecific organic anion transporter mediated transport pathway; .
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: OATP-1; Oatp1; organic anion-transporting polypeptide 1; Slc21a1; Slc21a3; sodium-independent organic anion transporter 1; solute carrier family (organic anion transporter) member 1; solute carrier family (organic anion transporter) member 3; solute carrier family 21 member 1; solute carrier family 21, member 1; solute carrier organic anion transporter family member 1A1; solute carrier organic anion transporter family member 1A1-like
RGD Orthologs
Alliance Orthologs
More Info homologs ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84176,606,924 - 176,682,027 (-)NCBIGRCr8
mRatBN7.24174,877,045 - 174,950,900 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4174,876,593 - 174,950,873 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx4181,171,932 - 181,245,799 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04176,956,227 - 177,030,092 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04175,576,756 - 175,650,620 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.04176,158,174 - 176,231,331 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4176,158,640 - 176,231,344 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04240,374,352 - 240,447,509 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.14179,739,781 - 179,773,529 (-)NCBI
Celera4163,412,182 - 163,485,720 (-)NCBICelera
Cytogenetic Map4q44NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Gender difference in the Oatp1-mediated tubular reabsorption of estradiol 17beta-D-glucuronide in rats. Gotoh Y, etal., Am J Physiol Endocrinol Metab 2002 Jun;282(6):E1245-54.
3. Distribution of organic anion-transporting polypeptide 2 (oatp2) and oatp3 in the rat retina. Ito A, etal., Invest Ophthalmol Vis Sci 2002 Mar;43(3):858-63.
4. Expression cloning of a rat liver Na(+)-independent organic anion transporter. Jacquemin E, etal., Proc Natl Acad Sci U S A 1994 Jan 4;91(1):133-7.
5. Increased hepatic and renal expressions of multidrug resistance-associated protein 3 in Eisai hyperbilirubinuria rats. Kuroda M, etal., J Gastroenterol Hepatol. 2004 Feb;19(2):146-53.
6. Mechanisms of pH-gradient driven transport mediated by organic anion polypeptide transporters. Leuthold S, etal., Am J Physiol Cell Physiol. 2009 Mar;296(3):C570-82. doi: 10.1152/ajpcell.00436.2008. Epub 2009 Jan 7.
7. Transport of the sulfated, amidated bile acid, sulfolithocholyltaurine, into rat hepatocytes is mediated by Oatp1 and Oatp2. Meng LJ, etal., Hepatology 2002 May;35(5):1031-40.
8. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
9. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
10. Magnetic resonance imaging with hepatospecific contrast agents in cirrhotic rat livers. Planchamp C, etal., Invest Radiol. 2005 Apr;40(4):187-94.
11. GOA pipeline RGD automated data pipeline
12. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
13. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
14. Messenger RNA profiles in liver injury and stress: a comparison of lethal and nonlethal rat models. Tygstrup N, etal., Biochem Biophys Res Commun 2002 Jan 11;290(1):518-25.
Additional References at PubMed
PMID:12130705   PMID:12702494   PMID:12842829   PMID:12883478   PMID:12923172   PMID:15878738   PMID:15994332   PMID:16519530   PMID:17640976   PMID:17845533   PMID:18031729   PMID:18308854  
PMID:18922885   PMID:21183661   PMID:22576625   PMID:24393554   PMID:25581836   PMID:26254357   PMID:27780379   PMID:31102415  


Genomics

Variants

.
Variants in Slco1a1
125 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:59
Count of miRNA genes:54
Interacting mature miRNAs:55
Transcripts:ENSRNOT00000049154
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
6478754Anxrr43Anxiety related response QTL 430.14035locomotor behavior trait (VT:0001392)distance moved per unit of time into, out of or within a discrete space in an experimental apparatus (CMO:0001493)4144639524182687754Rat
1576316Ept5Estrogen-induced pituitary tumorigenesis QTL 53.8pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)483428419177635233Rat
2303623Vencon2Ventilatory control QTL 23.8respiration trait (VT:0001943)minute ventilation (CMO:0000132)4135204660180204660Rat
724558Plsm2Polydactyly-luxate syndrome (PLS) morphotypes QTL 20.0003hindlimb integrity trait (VT:0010563)hind foot phalanges count (CMO:0001949)4132422778177422778Rat
6478693Anxrr32Anxiety related response QTL 320.00092locomotor behavior trait (VT:0001392)measurement of voluntary locomotion into, out of or within a discrete space in an experimental apparatus (CMO:0000957)4144639524182687754Rat
1578674Bmd12Bone mineral density QTL 123.8femur mineral mass (VT:0010011)compact volumetric bone mineral density (CMO:0001730)4135699135180699135Rat
1331738Bp209Blood pressure QTL 2092.979arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)4138503169179293946Rat
6478700Anxrr33Anxiety related response QTL 330.00896locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4144639524182687754Rat
634342Cia24Collagen induced arthritis QTL 244.5joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4146565735175236377Rat
10053718Scort25Serum corticosterone level QTL 252.150.0097blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)4155561574182687754Rat
1549827Scl46Serum cholesterol level QTL 463.5blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)4132396220177396220Rat
2293659Bmd35Bone mineral density QTL 354.50.0001femur strength trait (VT:0010010)femoral neck ultimate force (CMO:0001703)4137755016181392681Rat
10401796Kidm48Kidney mass QTL 48kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)4145568712182687754Rat
6478718Anxrr34Anxiety related response QTL 340.00896locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4144639524182687754Rat
2316958Gluco58Glucose level QTL 5810blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)411320076180699135Rat
1300109Rf13Renal function QTL 133.91renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)4157710145182687754Rat
6478748Anxrr42Anxiety related response QTL 420.28008locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4144639524182687754Rat

Markers in Region
D4Rat288  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.24175,181,600 - 175,181,807 (+)MAPPERmRatBN7.2
Rnor_6.04176,455,129 - 176,455,335NCBIRnor6.0
Rnor_5.04240,670,233 - 240,670,439UniSTSRnor5.0
RGSC_v3.44179,799,414 - 179,799,620UniSTSRGSC3.4
Celera4163,714,632 - 163,714,838UniSTS
FHH x ACI Map4111.32UniSTS
FHH x ACI Map4111.32RGD
Cytogenetic Map4q44UniSTS
PMC19316P1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.24174,877,453 - 174,877,836 (+)MAPPERmRatBN7.2
mRatBN7.24175,072,367 - 175,072,751 (+)MAPPERmRatBN7.2
Rnor_6.04176,345,896 - 176,346,279NCBIRnor6.0
Rnor_6.04176,158,583 - 176,158,965NCBIRnor6.0
Rnor_5.04240,560,748 - 240,561,131UniSTSRnor5.0
Rnor_5.04240,374,761 - 240,375,143UniSTSRnor5.0
RGSC_v3.44179,431,605 - 179,431,987UniSTSRGSC3.4
RGSC_v3.44179,688,414 - 179,688,797UniSTSRGSC3.4
Celera4163,606,297 - 163,606,680UniSTS
Celera4163,412,591 - 163,412,973UniSTS
Cytogenetic Map4q44UniSTS
RH139685  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.24174,975,217 - 174,975,415 (+)MAPPERmRatBN7.2
Rnor_6.04176,255,699 - 176,255,896NCBIRnor6.0
Rnor_5.04240,471,877 - 240,472,074UniSTSRnor5.0
RGSC_v3.44179,552,760 - 179,552,957UniSTSRGSC3.4
Celera4163,510,075 - 163,510,272UniSTS
RH 3.4 Map41043.4UniSTS
Cytogenetic Map4q44UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
6 7 8 45 77 76 47 16 47 6 141 44 25 37 34 29

Sequence


Ensembl Acc Id: ENSRNOT00000049154   ⟹   ENSRNOP00000040752
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl4174,879,496 - 174,950,873 (-)Ensembl
Rnor_6.0 Ensembl4176,158,640 - 176,231,344 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000102966   ⟹   ENSRNOP00000078030
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl4174,876,593 - 174,950,873 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000114721   ⟹   ENSRNOP00000084066
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl4174,876,593 - 174,928,079 (-)Ensembl
RefSeq Acc Id: NM_017111   ⟹   NP_058807
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84176,608,139 - 176,681,992 (-)NCBI
mRatBN7.24174,877,045 - 174,950,900 (-)NCBI
Rnor_6.04176,158,174 - 176,231,331 (-)NCBI
Rnor_5.04240,374,352 - 240,447,509 (-)NCBI
Celera4163,412,182 - 163,485,720 (-)RGD
Sequence:
RefSeq Acc Id: XM_063286619   ⟹   XP_063142689
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84176,606,924 - 176,682,027 (-)NCBI
RefSeq Acc Id: XM_063286620   ⟹   XP_063142690
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84176,611,644 - 176,682,008 (-)NCBI
RefSeq Acc Id: XM_063286621   ⟹   XP_063142691
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84176,608,839 - 176,682,008 (-)NCBI
RefSeq Acc Id: NP_058807   ⟸   NM_017111
- UniProtKB: P46720 (UniProtKB/Swiss-Prot),   A6IMP9 (UniProtKB/TrEMBL),   A0A8I5ZY22 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000040752   ⟸   ENSRNOT00000049154
Ensembl Acc Id: ENSRNOP00000078030   ⟸   ENSRNOT00000102966
Ensembl Acc Id: ENSRNOP00000084066   ⟸   ENSRNOT00000114721
RefSeq Acc Id: XP_063142689   ⟸   XM_063286619
- Peptide Label: isoform X1
- UniProtKB: P46720 (UniProtKB/Swiss-Prot),   A6IMP9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063142691   ⟸   XM_063286621
- Peptide Label: isoform X3
RefSeq Acc Id: XP_063142690   ⟸   XM_063286620
- Peptide Label: isoform X2
Protein Domains
Kazal-like   Major facilitator superfamily (MFS) profile

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P46720-F1-model_v2 AlphaFold P46720 1-670 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13693482
Promoter ID:EPDNEW_R4005
Type:initiation region
Name:Slco1a1_1
Description:solute carrier organic anion transporter family, member 1a1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.04176,231,361 - 176,231,421EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3700 AgrOrtholog
BioCyc Gene G2FUF-42504 BioCyc
Ensembl Genes ENSRNOG00000036984 Ensembl, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSRNOG00055010204 UniProtKB/Swiss-Prot
  ENSRNOG00060008158 UniProtKB/Swiss-Prot
  ENSRNOG00065005596 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000049154.5 UniProtKB/TrEMBL
  ENSRNOT00000102966.1 UniProtKB/Swiss-Prot
  ENSRNOT00000114721.1 UniProtKB/TrEMBL
  ENSRNOT00055017285 UniProtKB/Swiss-Prot
  ENSRNOT00060013560 UniProtKB/Swiss-Prot
  ENSRNOT00065008315 UniProtKB/Swiss-Prot
Gene3D-CATH 1.20.1250.20 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.30.60.30 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Kazal_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Kazal_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MFS_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MFS_trans_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  OATP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:50572 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 50572 ENTREZGENE
PANTHER PTHR11388 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SOLUTE CARRIER ORGANIC ANION TRANSPORTER FAMILY MEMBER 1A1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Kazal_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  OATP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Slco1a1 PhenoGen
PROSITE KAZAL_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MFS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000036984 RatGTEx
  ENSRNOG00055010204 RatGTEx
  ENSRNOG00060008158 RatGTEx
  ENSRNOG00065005596 RatGTEx
Superfamily-SCOP SSF100895 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF103473 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I5ZY22 ENTREZGENE, UniProtKB/TrEMBL
  A0A8L2QM78_RAT UniProtKB/TrEMBL
  A6IMP9 ENTREZGENE, UniProtKB/TrEMBL
  P46720 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2006-10-28 Slco1a1  solute carrier organic anion transporter family, member 1a1  Slc21a1  solute carrier family 21, member 1   Symbol and Name updated to reflect Human and Mouse nomenclature 1299863 APPROVED
2002-06-10 Slc21a1  solute carrier family 21, member 1       Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_cellular_localization localized at the sinusoidal plasma membrane of the liver and at the apical plasma membrane of the kidney in the S3 segment of the proximal tubule of the outer medulla 625763
gene_expression expression altered in response to certain types of liver damage 70249
gene_expression expressed in the retina 70527
gene_expression expressed in kidney with the expression level 20% (one-fifth) less in female than in male rats 625763
gene_process involved in tubular reabsorption (urinary clearance) of estradiol 17b-D-glucuronide which is 250-fold higher in females compared with males 625763
gene_regulation expression is mediated by the level of testosterone 625763