Slc1a3 (solute carrier family 1 member 3) - Rat Genome Database

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Gene: Slc1a3 (solute carrier family 1 member 3) Rattus norvegicus
Analyze
Symbol: Slc1a3
Name: solute carrier family 1 member 3
RGD ID: 3698
Description: Enables high-affinity L-glutamate transmembrane transporter activity. Involved in L-aspartate import across plasma membrane; L-glutamate import across plasma membrane; and malate-aspartate shuttle. Acts upstream of or within L-glutamate transmembrane transport. Located in several cellular components, including basolateral plasma membrane; dendritic spine; and neuronal cell body. Part of membrane protein complex. Human ortholog(s) of this gene implicated in episodic ataxia type 6. Orthologous to human SLC1A3 (solute carrier family 1 member 3); PARTICIPATES IN nicotinamide adenine dinucleotide metabolic pathway; glutamate signaling pathway; INTERACTS WITH 1-naphthyl isothiocyanate; 17alpha-ethynylestradiol; 17beta-estradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: EAAT1; excitatory amino acid transporter 1; GLAST; GLAST-1; glial glutamate transporter; GluT-1; glutamate transporter; glutamate/aspartate transporter; sodium-dependent glutamate/aspartate transporter 1; solute carrier family 1 (glial high affinity glutamate transporter), member 3; solute carrier family 1, member 3
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8259,482,707 - 59,557,808 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl259,482,709 - 59,557,808 (-)EnsemblGRCr8
mRatBN7.2257,755,495 - 57,830,605 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl257,755,497 - 57,830,605 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx264,851,543 - 64,926,640 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0262,946,162 - 63,021,300 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0257,947,345 - 58,022,485 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0257,860,881 - 57,935,363 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl257,860,834 - 57,935,363 (-)Ensemblrn6Rnor6.0
Rnor_5.0279,348,443 - 79,422,645 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4258,270,236 - 58,347,613 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera253,367,866 - 53,442,429 (-)NCBICelera
RGSC_v3.1258,198,470 - 58,275,846 (-)NCBI
Cytogenetic Map2q16NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1-naphthyl isothiocyanate  (EXP)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (EXP,ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2-chloroethanol  (EXP)
2-palmitoylglycerol  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3,4-methylenedioxymethamphetamine  (EXP,ISO)
3-chloropropane-1,2-diol  (EXP)
4-hydroxyphenyl retinamide  (ISO)
6-propyl-2-thiouracil  (EXP)
7,12-dimethyltetraphene  (EXP)
acetamide  (EXP)
acrolein  (EXP)
acrylamide  (EXP)
aflatoxin B1  (ISO)
agathisflavone  (EXP)
aldehydo-D-glucose  (EXP)
all-trans-retinoic acid  (ISO)
amiodarone  (ISO)
amitrole  (EXP)
ammonium chloride  (EXP)
androgen antagonist  (EXP)
atorvastatin calcium  (ISO)
atrazine  (EXP)
belinostat  (ISO)
benzo[a]pyrene  (ISO)
bexarotene  (EXP)
bis(2-chloroethyl) sulfide  (ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
Brodifacoum  (EXP)
bromobenzene  (EXP)
Butylparaben  (EXP)
butyric acid  (ISO)
cadmium atom  (ISO)
calcidiol  (EXP)
calcitriol  (ISO)
captan  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
chloroprene  (ISO)
chlorpyrifos  (EXP,ISO)
cholesterol  (ISO)
cisplatin  (ISO)
cobalt dichloride  (ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
coumarin  (ISO)
crocidolite asbestos  (ISO)
curcumin  (EXP)
D-glucose  (EXP)
deoxynivalenol  (EXP)
dexamethasone  (ISO)
diazepam  (EXP)
diazinon  (EXP)
dibutyl phthalate  (EXP)
dioxygen  (EXP)
diphenyl diselenide  (EXP)
dorsomorphin  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
enzacamene  (EXP)
ethanol  (EXP,ISO)
excitatory amino acid agonist  (EXP)
folpet  (ISO)
furan  (EXP)
genistein  (ISO)
gentamycin  (EXP)
glucose  (EXP)
haloperidol  (EXP)
hexadecanoic acid  (ISO)
hydrogen peroxide  (ISO)
ivermectin  (ISO)
kanamycin A  (ISO)
lanthanum trichloride  (EXP)
lead diacetate  (EXP)
lead(0)  (EXP)
manganese atom  (EXP,ISO)
manganese(0)  (EXP,ISO)
manganese(II) chloride  (EXP,ISO)
manganese(II) sulfate  (EXP)
medroxyprogesterone acetate  (ISO)
methamphetamine  (EXP)
methimazole  (EXP)
methylmercury chloride  (EXP)
mono(2-ethylhexyl) phthalate  (ISO)
ochratoxin A  (EXP)
oxaliplatin  (EXP)
oxidopamine  (EXP)
ozone  (ISO)
paclitaxel  (EXP)
panobinostat  (ISO)
paracetamol  (EXP,ISO)
paraoxon  (EXP)
PCB138  (EXP)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
perfluorooctanoic acid  (ISO)
phenylephrine  (EXP)
picoxystrobin  (ISO)
pirinixic acid  (EXP)
pregnenolone 16alpha-carbonitrile  (EXP)
progesterone  (ISO)
pyrrolidine dithiocarbamate  (EXP)
raloxifene  (EXP)
resveratrol  (EXP)
Riluzole  (EXP)
SB 431542  (ISO)
sodium arsenite  (EXP,ISO)
streptozocin  (EXP)
sulfadimethoxine  (EXP)
sulforaphane  (ISO)
sunitinib  (ISO)
tamoxifen  (EXP,ISO)
testosterone  (ISO)
tetrachloromethane  (EXP)
thioacetamide  (EXP)
thiram  (ISO)
titanium dioxide  (ISO)
topotecan  (EXP)
trichloroethene  (EXP)
trichostatin A  (ISO)
triclosan  (ISO)
trimellitic anhydride  (ISO)
tunicamycin  (ISO)
valproic acid  (EXP,ISO)
vinclozolin  (EXP)
vorinostat  (ISO)
XL147  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Similar perisynaptic glial localization for the Na+,K+-ATPase alpha 2 subunit and the glutamate transporters GLAST and GLT-1 in the rat somatosensory cortex. Cholet N, etal., Cereb Cortex 2002 May;12(5):515-25.
2. Preconditioning with cortical spreading depression decreases intraischemic cerebral glutamate levels and down-regulates excitatory amino acid transporters EAAT1 and EAAT2 from rat cerebal cortex plasma membranes. Douen AG, etal., J Neurochem. 2000 Aug;75(2):812-8.
3. Glutamate transporter protein subtypes are expressed differentially during rat CNS development. Furuta A, etal., J Neurosci. 1997 Nov 1;17(21):8363-75.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
6. The open reading frame of the Na(+)-dependent glutamate transporter GLAST-1 is expressed in bone and a splice variant of this molecule is expressed in bone and brain. Huggett J, etal., FEBS Lett 2000 Nov 17;485(1):13-8.
7. Cloning and expression of a bovine glutamate transporter. Inoue K, etal., Brain Res Mol Brain Res. 1995 Feb;28(2):343-8.
8. The number of glutamate transporter subtype molecules at glutamatergic synapses: chemical and stereological quantification in young adult rat brain. Lehre KP and Danbolt NC, J Neurosci. 1998 Nov 1;18(21):8751-7.
9. Identification of a glutamate/aspartate transporter in the rat cochlea. Li HS, etal., Hear Res 1994 Aug;78(2):235-42.
10. Neuronal and astrocytic shuttle mechanisms for cytosolic-mitochondrial transfer of reducing equivalents: current evidence and pharmacological tools. McKenna MC, etal., Biochem Pharmacol. 2006 Feb 14;71(4):399-407. Epub 2005 Dec 20.
11. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
12. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
13. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
14. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
15. Localization and function of the brain excitatory amino acid transporter type 1 in cardiac mitochondria. Ralphe JC, etal., J Mol Cell Cardiol. 2004 Jul;37(1):33-41.
16. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
17. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
18. Excitatory Amino Acid Transporter 1-Mediated L-Glutamate Transport at the Inner Blood-Retinal Barrier: Possible Role in L-Glutamate Elimination from the Retina. Sakurai T, etal., Biol Pharm Bull. 2015;38(7):1087-91. doi: 10.1248/bpb.b15-00226.
19. Structure, expression, and functional analysis of a Na(+)-dependent glutamate/aspartate transporter from rat brain. Storck T, etal., Proc Natl Acad Sci U S A 1992 Nov 15;89(22):10955-9.
20. Discrete cellular and subcellular localization of glutamine synthetase and the glutamate transporter GLAST in the rat vestibular end organ. Takumi Y, etal., Neuroscience. 1997 Aug;79(4):1137-44.
21. Expression cloning of a rat glutamate transporter. Tanaka K Neurosci Res 1993 Feb;16(2):149-53.
22. Object-based analysis of astroglial reaction and astrocyte subtype morphology after ischemic brain injury. Wagner DC, etal., Acta Neurobiol Exp (Wars). 2013;73(1):79-87.
23. NAD+/NADH and NADP+/NADPH in cellular functions and cell death: regulation and biological consequences. Ying W Antioxid Redox Signal. 2008 Feb;10(2):179-206.
Additional References at PubMed
PMID:7521911   PMID:7903437   PMID:8123008   PMID:8521863   PMID:9364068   PMID:9539795   PMID:9671661   PMID:9753165   PMID:11102482   PMID:11133151   PMID:12440940   PMID:12957496  
PMID:12971893   PMID:14723703   PMID:15305132   PMID:15337311   PMID:15390100   PMID:15615843   PMID:15661376   PMID:15862894   PMID:15965470   PMID:16093329   PMID:16123171   PMID:16738240  
PMID:16775204   PMID:16855093   PMID:16868771   PMID:16959378   PMID:17048262   PMID:17179860   PMID:17346885   PMID:17590480   PMID:17684014   PMID:18028233   PMID:18671901   PMID:18720515  
PMID:19323820   PMID:19440835   PMID:19551376   PMID:19553454   PMID:19570219   PMID:19717015   PMID:19728998   PMID:19804828   PMID:20477940   PMID:20521381   PMID:20531390   PMID:21233495  
PMID:21971915   PMID:22026960   PMID:22134673   PMID:22252783   PMID:22339645   PMID:22871113   PMID:22886112   PMID:23070469   PMID:23392471   PMID:23638698   PMID:24692063   PMID:25454285  
PMID:26037264   PMID:26269591   PMID:26690923   PMID:26920805   PMID:27003918   PMID:27769869   PMID:27889915   PMID:28032905   PMID:28104249   PMID:29476059   PMID:32357304   PMID:35551669  
PMID:36416239  


Genomics

Comparative Map Data
Slc1a3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8259,482,707 - 59,557,808 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl259,482,709 - 59,557,808 (-)EnsemblGRCr8
mRatBN7.2257,755,495 - 57,830,605 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl257,755,497 - 57,830,605 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx264,851,543 - 64,926,640 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0262,946,162 - 63,021,300 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0257,947,345 - 58,022,485 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0257,860,881 - 57,935,363 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl257,860,834 - 57,935,363 (-)Ensemblrn6Rnor6.0
Rnor_5.0279,348,443 - 79,422,645 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4258,270,236 - 58,347,613 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera253,367,866 - 53,442,429 (-)NCBICelera
RGSC_v3.1258,198,470 - 58,275,846 (-)NCBI
Cytogenetic Map2q16NCBI
SLC1A3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38536,596,588 - 36,688,334 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl536,596,588 - 36,688,335 (+)Ensemblhg38GRCh38
GRCh37536,606,708 - 36,688,436 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36536,642,446 - 36,724,191 (+)NCBIBuild 36Build 36hg18NCBI36
Build 34536,642,447 - 36,724,197NCBI
Celera536,493,385 - 36,575,353 (+)NCBICelera
Cytogenetic Map5p13.2NCBI
HuRef536,559,517 - 36,641,481 (+)NCBIHuRef
CHM1_1536,609,230 - 36,691,155 (+)NCBICHM1_1
T2T-CHM13v2.0536,846,426 - 36,938,148 (+)NCBIT2T-CHM13v2.0
Slc1a3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39158,663,608 - 8,742,648 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl158,663,608 - 8,740,248 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38158,634,124 - 8,710,807 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl158,634,124 - 8,710,764 (-)Ensemblmm10GRCm38
MGSCv37158,584,124 - 8,660,807 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36158,581,339 - 8,657,945 (-)NCBIMGSCv36mm8
Celera158,479,667 - 8,556,633 (-)NCBICelera
Cytogenetic Map15A1NCBI
cM Map153.82NCBI
Slc1a3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542621,371,985 - 21,451,069 (+)Ensembl
ChiLan1.0NW_00495542621,371,985 - 21,450,749 (+)NCBIChiLan1.0ChiLan1.0
SLC1A3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2473,645,238 - 73,727,200 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1571,798,870 - 71,880,587 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0573,679,841 - 73,761,591 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1578,960,797 - 79,042,694 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl578,960,797 - 79,042,694 (-)EnsemblpanPan2panpan1.1
SLC1A3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1471,936,128 - 72,014,119 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl471,936,126 - 72,014,173 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha471,545,756 - 71,624,038 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0472,446,075 - 72,524,440 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl472,445,714 - 72,524,563 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1472,192,176 - 72,270,091 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0472,315,043 - 72,393,341 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0472,846,428 - 72,924,441 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Slc1a3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213226,079,921 - 226,156,414 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365185,215,290 - 5,291,058 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365185,216,343 - 5,291,107 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SLC1A3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1621,873,691 - 21,964,990 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11621,873,691 - 21,965,315 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21622,924,641 - 23,007,781 (+)NCBISscrofa10.2Sscrofa10.2susScr3
SLC1A3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1435,473,425 - 35,557,118 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl435,473,658 - 35,557,138 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366607125,803,256 - 25,886,938 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Slc1a3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475918,325,147 - 18,400,431 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462475918,325,272 - 18,400,447 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Slc1a3
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v13171,794,220 - 171,868,023 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Slc1a3
238 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:818
Count of miRNA genes:256
Interacting mature miRNAs:326
Transcripts:ENSRNOT00000022319, ENSRNOT00000035821
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
6480225Gdil1Gastrointestinal dilation QTL 1enteric ganglion morphology trait (VT:0001045)length of intestine affected by colonic aganglionosis to total length of colon ratio (CMO:0001836)25838820177302351Rat
7387318Stl32Serum triglyceride level QTL 323.20.0003blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)22411781369117813Rat
10755436Coatc8Coat color QTL 80.02431coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)23675034481750344Rat
1298074Bp164Blood pressure QTL 1640.003arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)244537979205135428Rat
10755499Bp389Blood pressure QTL 3892.61arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)220695736231474293Rat
1358917Cm42Cardiac mass QTL 422.82heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)227148328206613235Rat
1579916Bp270Blood pressure QTL 2700.003arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)21605188361051883Rat
731167Glom4Glomerulus QTL 42.40.0082kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)22203804467038044Rat
1358913Cm41Cardiac mass QTL 412.73heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)227148328206613235Rat
152025242Bw191Body weight QTL 1913.62body mass (VT:0001259)240306867124537199Rat
1302794Stl27Serum triglyceride level QTL 274.40.0001blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)227148328145807373Rat
9590095Sffal3Serum free fatty acids level QTL 36.780.001blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)22888999173889991Rat
70174BpQTLCluster2Blood pressure QTL cluster 24.24arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)241801363104744824Rat
1358901Cm38Cardiac mass QTL 382heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)227148328159440891Rat
631208Bw1Body weight QTL15.09mesenteric fat pad mass (VT:0010427)mesenteric fat pad weight to body weight ratio (CMO:0000654)24490435585286097Rat
1331760Bp206Blood pressure QTL 2063.62454arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)24265106205135428Rat
1358899Kidm23Kidney mass QTL 233.88kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)227148328159440891Rat
1358908Bw49Body weight QTL 493.36body mass (VT:0001259)body weight (CMO:0000012)227148557159440760Rat
1300155Bp174Blood pressure QTL 1744.09arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)244537979112567334Rat
2293835Kiddil5Kidney dilation QTL 53.8kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)244537979159440891Rat
1358910Kidm27Kidney mass QTL 275.77kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)227148328159440891Rat
61355Bp36Blood pressure QTL 362.9blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)27605533104774005Rat
1358911Kidm28Kidney mass QTL 285.42kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)227148328159440891Rat
631266Bp132Blood pressure QTL 1320.0005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)247856345205135428Rat
1358904Cm39Cardiac mass QTL 392.26heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)227148328159440891Rat
1354617Bp240Blood pressure QTL 2404arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)22865266683465677Rat
1359034Bp274Blood pressure QTL 274arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)25126685996266859Rat
2293843Kiddil6Kidney dilation QTL 63.1kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)244537979184731399Rat
1358887Bw50Body weight QTL 502.39body mass (VT:0001259)body weight (CMO:0000012)227148557159440760Rat
2306903Bp336Blood pressure QTL 3360.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)238426449111295694Rat
1298085Bp165Blood pressure QTL 1650.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)244537979205135428Rat
2290453Scl55Serum cholesterol level QTL 552.83blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)228652666139067443Rat
152025206Hrtrt23Heart rate QTL 235.98heart pumping trait (VT:2000009)230219200171802126Rat
1358894Kidm24Kidney mass QTL 244.03kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)227148328159440891Rat
731184Mamtr4Mammary tumor resistance QTL 40.0003mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)21822713763227137Rat
152025204Hrtrt22Heart rate QTL 225.6heart pumping trait (VT:2000009)230219200171802126Rat
61371Edpm1Estrogen-dependent pituitary mass QTL 140.05pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)23686864381868643Rat
1354601Slep1Serum leptin concentration QTL 15.39blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)24490435589904355Rat
1582246Cm60Cardiac mass QTL 605.8heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)23326999678269996Rat
1354603Bp243Blood pressure QTL 2433.9arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)22865266673652666Rat

Markers in Region
AI504299  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2257,808,115 - 57,808,207 (+)MAPPERmRatBN7.2
Rnor_6.0257,912,870 - 57,912,961NCBIRnor6.0
Rnor_5.0279,400,231 - 79,400,322UniSTSRnor5.0
RGSC_v3.4258,325,197 - 58,325,288UniSTSRGSC3.4
Celera253,419,930 - 53,420,021UniSTS
Cytogenetic Map2q16UniSTS
RH143474  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2257,788,150 - 57,788,368 (+)MAPPERmRatBN7.2
Rnor_6.0257,893,532 - 57,893,749NCBIRnor6.0
Rnor_5.0279,381,094 - 79,381,311UniSTSRnor5.0
RGSC_v3.4258,302,892 - 58,303,109UniSTSRGSC3.4
Celera253,400,521 - 53,400,738UniSTS
Cytogenetic Map2q16UniSTS
RH139535  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2257,755,677 - 57,755,868 (+)MAPPERmRatBN7.2
Rnor_6.0257,861,064 - 57,861,254NCBIRnor6.0
Rnor_5.0279,348,626 - 79,348,816UniSTSRnor5.0
RGSC_v3.4258,270,419 - 58,270,609UniSTSRGSC3.4
Celera253,368,049 - 53,368,239UniSTS
RH 3.4 Map2333.7UniSTS
Cytogenetic Map2q16UniSTS
RH140370  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2257,755,744 - 57,755,875 (+)MAPPERmRatBN7.2
Rnor_6.0257,861,131 - 57,861,261NCBIRnor6.0
Rnor_5.0279,348,693 - 79,348,823UniSTSRnor5.0
RGSC_v3.4258,270,486 - 58,270,616UniSTSRGSC3.4
Celera253,368,116 - 53,368,246UniSTS
Cytogenetic Map2q16UniSTS
AU049927  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2257,765,991 - 57,766,219 (+)MAPPERmRatBN7.2
Rnor_6.0257,871,378 - 57,871,605NCBIRnor6.0
Rnor_5.0279,358,940 - 79,359,167UniSTSRnor5.0
RGSC_v3.4258,280,735 - 58,280,962UniSTSRGSC3.4
Celera253,378,363 - 53,378,590UniSTS
Cytogenetic Map2q16UniSTS
GDB:335409  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21130,922,942 - 30,923,111 (+)MAPPERmRatBN7.2
mRatBN7.2257,767,720 - 57,767,887 (+)MAPPERmRatBN7.2
Rnor_6.0257,873,107 - 57,873,273NCBIRnor6.0
Rnor_6.01131,837,545 - 31,837,713NCBIRnor6.0
Rnor_5.01135,446,278 - 35,446,446UniSTSRnor5.0
Rnor_5.0279,360,669 - 79,360,835UniSTSRnor5.0
RGSC_v3.4258,282,464 - 58,282,630UniSTSRGSC3.4
RGSC_v3.41131,651,927 - 31,652,095UniSTSRGSC3.4
Celera1130,590,374 - 30,590,542UniSTS
Celera253,380,092 - 53,380,258UniSTS
Cytogenetic Map11q11UniSTS
Cytogenetic Map2q16UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 162 91 90 59 43 59 6 306 143 11 141 80 92 31 14 14

Sequence


Ensembl Acc Id: ENSRNOT00000022319   ⟹   ENSRNOP00000022319
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl259,482,709 - 59,557,787 (-)Ensembl
mRatBN7.2 Ensembl257,755,497 - 57,830,584 (-)Ensembl
Rnor_6.0 Ensembl257,860,834 - 57,935,334 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000035821   ⟹   ENSRNOP00000036554
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl259,482,709 - 59,557,808 (-)Ensembl
mRatBN7.2 Ensembl257,755,497 - 57,830,605 (-)Ensembl
Rnor_6.0 Ensembl257,860,883 - 57,935,363 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000077790   ⟹   ENSRNOP00000073634
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl259,482,709 - 59,557,797 (-)Ensembl
mRatBN7.2 Ensembl257,755,497 - 57,830,594 (-)Ensembl
Rnor_6.0 Ensembl257,860,883 - 57,935,352 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000085599   ⟹   ENSRNOP00000075509
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl259,482,709 - 59,557,797 (-)Ensembl
mRatBN7.2 Ensembl257,755,497 - 57,830,594 (-)Ensembl
Rnor_6.0 Ensembl257,860,883 - 57,935,352 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000102825   ⟹   ENSRNOP00000090933
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl259,534,790 - 59,557,797 (-)Ensembl
mRatBN7.2 Ensembl257,774,911 - 57,830,575 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000107277   ⟹   ENSRNOP00000088277
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl259,482,709 - 59,542,405 (-)Ensembl
mRatBN7.2 Ensembl257,755,497 - 57,814,969 (-)Ensembl
RefSeq Acc Id: NM_001289941   ⟹   NP_001276870
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8259,482,707 - 59,557,808 (-)NCBI
mRatBN7.2257,755,495 - 57,830,605 (-)NCBI
Rnor_6.0257,860,881 - 57,935,363 (-)NCBI
Celera253,367,866 - 53,442,429 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001289942   ⟹   NP_001276871
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8259,482,707 - 59,557,797 (-)NCBI
mRatBN7.2257,755,495 - 57,830,594 (-)NCBI
Rnor_6.0257,860,881 - 57,935,352 (-)NCBI
Celera253,367,866 - 53,442,418 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001289943   ⟹   NP_001276872
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8259,482,707 - 59,557,797 (-)NCBI
mRatBN7.2257,755,495 - 57,830,594 (-)NCBI
Rnor_6.0257,860,881 - 57,935,352 (-)NCBI
Celera253,367,866 - 53,442,418 (-)NCBI
Sequence:
RefSeq Acc Id: NM_019225   ⟹   NP_062098
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8259,482,707 - 59,557,787 (-)NCBI
mRatBN7.2257,755,495 - 57,830,584 (-)NCBI
Rnor_6.0257,860,881 - 57,935,342 (-)NCBI
Rnor_5.0279,348,443 - 79,422,645 (-)NCBI
RGSC_v3.4258,270,236 - 58,347,613 (-)RGD
Celera253,367,866 - 53,442,408 (-)NCBI
Sequence:
RefSeq Acc Id: NP_062098   ⟸   NM_019225
- Peptide Label: isoform 1
- UniProtKB: Q9JK43 (UniProtKB/Swiss-Prot),   P24942 (UniProtKB/Swiss-Prot),   G3V846 (UniProtKB/TrEMBL),   A6KGI6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001276870   ⟸   NM_001289941
- Peptide Label: isoform 2
- UniProtKB: Q9JK43 (UniProtKB/Swiss-Prot),   P24942 (UniProtKB/Swiss-Prot),   A0A0G2JSU1 (UniProtKB/TrEMBL),   A6KGI5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001276872   ⟸   NM_001289943
- Peptide Label: isoform 4
- UniProtKB: A0A0G2K611 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001276871   ⟸   NM_001289942
- Peptide Label: isoform 3
- UniProtKB: Q9JK43 (UniProtKB/Swiss-Prot),   P24942 (UniProtKB/Swiss-Prot),   A0A0G2KAS7 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000036554   ⟸   ENSRNOT00000035821
Ensembl Acc Id: ENSRNOP00000075509   ⟸   ENSRNOT00000085599
Ensembl Acc Id: ENSRNOP00000073634   ⟸   ENSRNOT00000077790
Ensembl Acc Id: ENSRNOP00000022319   ⟸   ENSRNOT00000022319
Ensembl Acc Id: ENSRNOP00000088277   ⟸   ENSRNOT00000107277
Ensembl Acc Id: ENSRNOP00000090933   ⟸   ENSRNOT00000102825

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P24942-F1-model_v2 AlphaFold P24942 1-543 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13691177
Promoter ID:EPDNEW_R1701
Type:initiation region
Name:Slc1a3_1
Description:solute carrier family 1 member 3
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0257,935,309 - 57,935,369EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3698 AgrOrtholog
BioCyc Gene G2FUF-54113 BioCyc
Ensembl Genes ENSRNOG00000016163 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000022319 ENTREZGENE
  ENSRNOT00000035821 ENTREZGENE
  ENSRNOT00000077790 ENTREZGENE
  ENSRNOT00000085599 ENTREZGENE
Gene3D-CATH 1.10.3860.10 UniProtKB/Swiss-Prot
InterPro DAACS UniProtKB/Swiss-Prot
  Na-dicarboxylate_symporter UniProtKB/Swiss-Prot
  Na-dicarboxylate_symporter_CS UniProtKB/Swiss-Prot
  Na:dicarbo_symporter_sf UniProtKB/Swiss-Prot
KEGG Report rno:29483 UniProtKB/Swiss-Prot
NCBI Gene 29483 ENTREZGENE
PANTHER EXCITATORY AMINO ACID TRANSPORTER 1 UniProtKB/Swiss-Prot
  SODIUM/DICARBOXYLATE SYMPORTER-RELATED UniProtKB/Swiss-Prot
Pfam SDF UniProtKB/Swiss-Prot
PhenoGen Slc1a3 PhenoGen
PRINTS EDTRNSPORT UniProtKB/Swiss-Prot
PROSITE NA_DICARBOXYL_SYMP_1 UniProtKB/Swiss-Prot
  NA_DICARBOXYL_SYMP_2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000016163 RatGTEx
Superfamily-SCOP SSF118215 UniProtKB/Swiss-Prot
UniProt A0A0G2JSU1 ENTREZGENE, UniProtKB/TrEMBL
  A0A0G2K611 ENTREZGENE, UniProtKB/TrEMBL
  A0A0G2KAS7 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6AAG6_RAT UniProtKB/TrEMBL
  A0A8I6ADJ9_RAT UniProtKB/TrEMBL
  A6KGI5 ENTREZGENE, UniProtKB/TrEMBL
  A6KGI6 ENTREZGENE, UniProtKB/TrEMBL
  EAA1_RAT UniProtKB/Swiss-Prot
  G3V846 ENTREZGENE, UniProtKB/TrEMBL
  P24942 ENTREZGENE
  Q9JK43 ENTREZGENE
UniProt Secondary Q9JK43 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-25 Slc1a3  solute carrier family 1 member 3  Slc1a3  solute carrier family 1 (glial high affinity glutamate transporter), member 3  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-09-10 Slc1a3  solute carrier family 1 (glial high affinity glutamate transporter), member 3    solute carrier family 1, member 3  Name updated 1299863 APPROVED
2002-06-10 Slc1a3  solute carrier family 1, member 3      Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in the cerebellar Purkinje cell layer, possibly in Bergmann glia cells 70007