Slc16a7 (solute carrier family 16 member 7) - Rat Genome Database

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Gene: Slc16a7 (solute carrier family 16 member 7) Rattus norvegicus
Analyze
Symbol: Slc16a7
Name: solute carrier family 16 member 7
RGD ID: 3691
Description: Enables symporter activity. Involved in plasma membrane lactate transport. Is active in several cellular components, including Schaffer collateral - CA1 synapse; hippocampal mossy fiber to CA3 synapse; and parallel fiber to Purkinje cell synapse. Orthologous to human SLC16A7 (solute carrier family 16 member 7); INTERACTS WITH (+)-schisandrin B; 17alpha-ethynylestradiol; 17beta-estradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: MCT 2; Mct2; MGC93092; monocarboxylate transporter 2; solute carrier family 16 (monocarboxylate transporter), member 7; solute carrier family 16 (monocarboxylic acid transporters) member 7; solute carrier family 16 (monocarboxylic acid transporters), member 7; solute carrier family 16, member 7; solute carrier family 16, member 7 (monocarboxylic acid transporter 2)
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8762,929,067 - 63,096,995 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl762,936,567 - 63,040,386 (-)EnsemblGRCr8
mRatBN7.2761,043,667 - 61,211,547 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl761,051,167 - 61,154,994 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx762,936,997 - 63,040,542 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0765,139,665 - 65,243,207 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0764,915,969 - 65,019,570 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0768,438,341 - 68,606,312 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl768,446,193 - 68,549,763 (-)Ensemblrn6Rnor6.0
Rnor_5.0768,633,417 - 68,801,189 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4765,210,148 - 65,313,572 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera758,206,868 - 58,309,915 (-)NCBICelera
RGSC_v3.1765,230,721 - 65,390,741 (-)NCBI
Cytogenetic Map7q22NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View
obesity  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(1->4)-beta-D-glucan  (ISO)
1,1-dichloroethene  (ISO)
1,2,4-trichloro-5-(2,5-dichlorophenyl)benzene  (ISO)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (EXP)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP,ISO)
2,4,4'-trichlorobiphenyl  (ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2,4-dinitrotoluene  (EXP)
3-chloropropane-1,2-diol  (EXP)
3-iodothyronamine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
acrolein  (ISO)
aflatoxin B1  (ISO)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (ISO)
alpha-pinene  (ISO)
amiodarone  (ISO)
ammonium chloride  (EXP)
AR-C155858  (EXP,ISO)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
bis(2-chloroethyl) sulfide  (EXP)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
Butylbenzyl phthalate  (ISO)
chlordecone  (ISO)
chlorpyrifos  (ISO)
ciguatoxin CTX1B  (ISO)
cisplatin  (ISO)
copper(II) sulfate  (ISO)
coumarin  (ISO)
crocidolite asbestos  (ISO)
D-glucose  (ISO)
dibenz[a,h]anthracene  (ISO)
dichloroacetic acid  (ISO)
dieldrin  (EXP)
dorsomorphin  (ISO)
doxorubicin  (ISO)
epoxiconazole  (ISO)
ethanol  (ISO)
finasteride  (EXP)
flavonoids  (EXP)
flutamide  (EXP)
formaldehyde  (ISO)
geldanamycin  (ISO)
glafenine  (EXP)
glucose  (ISO)
heptachlor  (EXP)
hydrogen peroxide  (ISO)
inulin  (ISO)
isotretinoin  (ISO)
lanthanum trichloride  (EXP)
leflunomide  (EXP)
Licochalcone B  (ISO)
methapyrilene  (EXP)
methidathion  (ISO)
methylseleninic acid  (ISO)
mirex  (EXP)
nefazodone  (EXP)
oxamic acid  (ISO)
ozone  (ISO)
p-chloromercuribenzoic acid  (ISO)
paracetamol  (EXP,ISO)
PCB138  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phenobarbital  (ISO)
phenylephrine  (EXP)
phenylmercury acetate  (ISO)
pirinixic acid  (ISO)
pregnenolone 16alpha-carbonitrile  (EXP)
progesterone  (ISO)
resveratrol  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
streptozocin  (ISO)
tamibarotene  (ISO)
testosterone enanthate  (ISO)
tetrachloroethene  (ISO)
tetrachloromethane  (EXP,ISO)
tetracycline  (ISO)
thallium atom  (EXP)
thallium sulfate  (EXP)
thioacetamide  (EXP)
thiram  (ISO)
titanium dioxide  (ISO)
trichloroethene  (EXP)
trichostatin A  (ISO)
triphenyl phosphate  (EXP,ISO)
Triptolide  (ISO)
valdecoxib  (EXP)
valproic acid  (EXP,ISO)
vancomycin  (ISO)
vinclozolin  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Selective postsynaptic co-localization of MCT2 with AMPA receptor GluR2/3 subunits at excitatory synapses exhibiting AMPA receptor trafficking. Bergersen LH, etal., Cereb Cortex. 2005 Apr;15(4):361-70. doi: 10.1093/cercor/bhh138.
2. Characterization of the high-affinity monocarboxylate transporter MCT2 in Xenopus laevis oocytes. Bröer S, etal., Biochem J. 1999 Aug 1;341 ( Pt 3):529-35. doi: 10.1042/0264-6021:3410529.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
5. Cloning of the monocarboxylate transporter isoform MCT2 from rat testis provides evidence that expression in tissues is species-specific and may involve post-transcriptional regulation. Jackson VN, etal., Biochem J 1997 Jun 1;324 ( Pt 2):447-53.
6. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
7. AR-C155858 is a potent inhibitor of monocarboxylate transporters MCT1 and MCT2 that binds to an intracellular site involving transmembrane helices 7-10. Ovens MJ, etal., Biochem J. 2010 Jan 15;425(3):523-30. doi: 10.1042/BJ20091515.
8. The inhibition of monocarboxylate transporter 2 (MCT2) by AR-C155858 is modulated by the associated ancillary protein. Ovens MJ, etal., Biochem J. 2010 Oct 15;431(2):217-25. doi: 10.1042/BJ20100890.
9. Highly differential expression of the monocarboxylate transporters MCT2 and MCT4 in the developing rat brain. Rafiki A, etal., Neuroscience 2003;122(3):677-88.
10. GOA pipeline RGD automated data pipeline
11. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
12. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
13. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
14. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
15. Basigin (CD147) is the target for organomercurial inhibition of monocarboxylate transporter isoforms 1 and 4: the ancillary protein for the insensitive MCT2 is EMBIGIN (gp70). Wilson MC, etal., J Biol Chem. 2005 Jul 22;280(29):27213-21. Epub 2005 May 24.
Additional References at PubMed
PMID:9482213   PMID:9786900   PMID:12966567   PMID:14534079   PMID:15505343   PMID:15932892   PMID:16516162   PMID:16943667   PMID:17416968   PMID:18084728   PMID:18523157   PMID:19262019  
PMID:19401710   PMID:21488089   PMID:21624469   PMID:21741392   PMID:21753001   PMID:23638108   PMID:24260123   PMID:24610532   PMID:25827488   PMID:26831515   PMID:28388627   PMID:30143583  


Genomics

Comparative Map Data
Slc16a7
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8762,929,067 - 63,096,995 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl762,936,567 - 63,040,386 (-)EnsemblGRCr8
mRatBN7.2761,043,667 - 61,211,547 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl761,051,167 - 61,154,994 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx762,936,997 - 63,040,542 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0765,139,665 - 65,243,207 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0764,915,969 - 65,019,570 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0768,438,341 - 68,606,312 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl768,446,193 - 68,549,763 (-)Ensemblrn6Rnor6.0
Rnor_5.0768,633,417 - 68,801,189 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4765,210,148 - 65,313,572 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera758,206,868 - 58,309,915 (-)NCBICelera
RGSC_v3.1765,230,721 - 65,390,741 (-)NCBI
Cytogenetic Map7q22NCBI
SLC16A7
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381259,596,029 - 59,789,841 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1259,596,027 - 59,789,855 (+)Ensemblhg38GRCh38
GRCh371259,989,810 - 60,183,622 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361258,369,393 - 58,461,675 (+)NCBIBuild 36Build 36hg18NCBI36
Build 341258,369,392 - 58,461,674NCBI
Celera1259,745,720 - 59,838,012 (+)NCBICelera
Cytogenetic Map12q14.1NCBI
HuRef1257,038,268 - 57,232,240 (+)NCBIHuRef
CHM1_11259,958,039 - 60,151,803 (+)NCBICHM1_1
T2T-CHM13v2.01259,572,554 - 59,766,418 (+)NCBIT2T-CHM13v2.0
Slc16a7
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3910125,055,139 - 125,225,455 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl10125,055,139 - 125,225,334 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm3810125,219,270 - 125,389,586 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl10125,219,270 - 125,389,465 (-)Ensemblmm10GRCm38
MGSCv3710124,664,541 - 124,765,591 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv3610124,630,545 - 124,731,595 (-)NCBIMGSCv36mm8
Celera10127,630,780 - 127,731,940 (-)NCBICelera
Cytogenetic Map10D3NCBI
cM Map1072.31NCBI
Slc16a7
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554587,232,886 - 7,352,782 (+)Ensembl
ChiLan1.0NW_0049554587,232,886 - 7,352,782 (+)NCBIChiLan1.0ChiLan1.0
SLC16A7
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21034,537,931 - 34,726,021 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11234,529,686 - 34,722,531 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01229,128,600 - 29,317,797 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11229,390,576 - 29,587,897 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1229,390,576 - 29,528,851 (-)EnsemblpanPan2panpan1.1
SLC16A7
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1103,333,000 - 3,500,684 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl103,334,126 - 3,496,150 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha103,398,668 - 3,564,721 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0103,356,472 - 3,522,599 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl103,357,277 - 3,519,865 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1103,323,639 - 3,489,625 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0103,565,685 - 3,731,591 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0103,691,746 - 3,857,780 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Slc16a7
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494555,219,046 - 55,388,105 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366463,533,590 - 3,642,526 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049366463,482,148 - 3,647,466 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SLC16A7
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl524,713,267 - 24,875,003 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1524,713,009 - 24,871,891 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2526,710,139 - 26,864,757 (+)NCBISscrofa10.2Sscrofa10.2susScr3
SLC16A7
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11155,541,313 - 55,709,102 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1155,645,129 - 55,708,356 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_023666037190,169,996 - 190,345,973 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Slc16a7
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248028,015,061 - 8,191,012 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046248028,015,061 - 8,191,031 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Slc16a7
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11203,715,019 - 203,868,751 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Slc16a7
585 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:133
Count of miRNA genes:95
Interacting mature miRNAs:119
Transcripts:ENSRNOT00000058036
Prediction methods:Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
7411569Bw137Body weight QTL 1370.001body mass (VT:0001259)body weight gain (CMO:0000420)72380760668807606Rat
10053722Scort27Serum corticosterone level QTL 272.410.0083blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)74511390390113903Rat
1549840Bss5Bone structure and strength QTL 59.8femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)72663805771638057Rat
1300127Srn1Serum renin concentration QTL 13.87blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)72417947886817926Rat
10059605Kidm47Kidney mass QTL 472.910.05kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)74913799967614020Rat
1357336Gluco6Glucose level QTL 63.4blood glucose amount (VT:0000188)serum glucose level (CMO:0000543)75170064396700643Rat
1358361Sradr5Stress Responsive Adrenal Weight QTL 55.55adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)731770293110435881Rat
1298525Cm1Cardiac mass QTL 12.7heart mass (VT:0007028)heart wet weight (CMO:0000069)756625161101625161Rat
631513Scl7Serum cholesterol level QTL 74.1blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)73984590284845902Rat
10755453Coatc12Coat color QTL 120coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)73299870277998702Rat
631504Cm27Cardiac mass QTL 273.45heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)746307490127866166Rat
2317059Aia15Adjuvant induced arthritis QTL 152.46joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)74968283263890004Rat
7411605Foco14Food consumption QTL 1424.10.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)73617876481178764Rat
1300151Bp181Blood pressure QTL 1813.36arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)755498584105834451Rat
1643004Pain2Pain QTL 21mechanical nociception trait (VT:0002734)self mutilation severity score (CMO:0002145)71011291699900612Rat
738030Anxrr8Anxiety related response QTL 84.1exploratory behavior trait (VT:0010471)number of entries into a discrete space in an experimental apparatus (CMO:0000960)74847504993475049Rat
1300149Cm6Cardiac mass QTL 64.09heart mass (VT:0007028)heart left ventricle weight to body weight ratio (CMO:0000530)71104117804Rat
631534Lnnr1Liver neoplastic nodule remodeling QTL 13.850.001liver integrity trait (VT:0010547)liver remodeling tumorous lesion number to liver total tumorous lesion number ratio (CMO:0001705)73617876481178764Rat
634336Anxrr17Anxiety related response QTL 173.66locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)71509236116977875Rat
61357Bp38Blood pressure QTL 381.60.052arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)740540077123682549Rat
70190Mcs6Mammary carcinoma susceptibility QTL 62.29mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)72862457565788017Rat
2316947Rf58Renal function QTL 587.8kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)749682832115766396Rat
1298528Bp169Blood pressure QTL 1690.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)762963207107963207Rat
1300132Bp182Blood pressure QTL 1823.49arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)72154197786817926Rat
2316955Stl24Serum triglyceride level QTL 247.1blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)749682832115766396Rat
2316952Pur22Proteinuria QTL 225.2urine protein amount (VT:0005160)urine protein level (CMO:0000591)749682832115766396Rat
61435Cia4Collagen induced arthritis QTL 45.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)75999866163890004Rat
2303582Gluco53Glucose level QTL 533blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)74860308793603087Rat
70207Niddm31Non-insulin dependent diabetes mellitus QTL 313.9blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)72005723265057232Rat
61439Cia8Collagen induced arthritis QTL 85.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)72718291472182914Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
23 13 78 217 91 90 59 120 59 6 447 241 22 195 116 121 31 34 34

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001439467 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001439468 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001439469 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001439470 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001439471 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001439472 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001439473 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_017302 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006241432 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006241433 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006241434 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006241435 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006241436 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006241437 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039078611 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039078612 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039078613 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039078614 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039078615 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039078616 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039078617 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063263138 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063263139 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063263140 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063263141 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide BC081701 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473950 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218176 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000007 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U62316 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X97445 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000058036   ⟹   ENSRNOP00000054845
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl762,936,567 - 63,040,386 (-)Ensembl
mRatBN7.2 Ensembl761,051,167 - 61,154,994 (-)Ensembl
Rnor_6.0 Ensembl768,446,193 - 68,512,397 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000077670   ⟹   ENSRNOP00000075465
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl768,446,768 - 68,523,364 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000078014   ⟹   ENSRNOP00000073329
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl768,446,353 - 68,549,763 (-)Ensembl
RefSeq Acc Id: NM_017302   ⟹   NP_058998
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8762,937,088 - 63,040,398 (-)NCBI
mRatBN7.2761,051,688 - 61,155,006 (-)NCBI
Rnor_6.0768,446,349 - 68,549,763 (-)NCBI
Rnor_5.0768,633,417 - 68,801,189 (-)NCBI
RGSC_v3.4765,210,148 - 65,313,572 (-)RGD
Celera758,206,868 - 58,309,915 (-)RGD
Sequence:
RefSeq Acc Id: XM_006241432   ⟹   XP_006241494
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8762,929,067 - 63,020,967 (-)NCBI
mRatBN7.2761,043,667 - 61,135,526 (-)NCBI
Rnor_6.0768,438,341 - 68,530,585 (-)NCBI
Rnor_5.0768,633,417 - 68,801,189 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006241433   ⟹   XP_006241495
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8762,929,067 - 63,040,695 (-)NCBI
mRatBN7.2761,043,667 - 61,156,096 (-)NCBI
Rnor_6.0768,444,488 - 68,550,023 (-)NCBI
Rnor_5.0768,633,417 - 68,801,189 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006241434   ⟹   XP_006241496
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8762,929,067 - 63,096,995 (-)NCBI
mRatBN7.2761,043,667 - 61,211,545 (-)NCBI
Rnor_6.0768,438,341 - 68,606,311 (-)NCBI
Rnor_5.0768,633,417 - 68,801,189 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006241435   ⟹   XP_006241497
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8762,929,067 - 63,040,695 (-)NCBI
mRatBN7.2761,043,667 - 61,156,096 (-)NCBI
Rnor_6.0768,444,488 - 68,550,023 (-)NCBI
Rnor_5.0768,633,417 - 68,801,189 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006241436   ⟹   XP_006241498
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8762,929,067 - 63,096,983 (-)NCBI
mRatBN7.2761,043,667 - 61,211,547 (-)NCBI
Rnor_6.0768,438,341 - 68,606,312 (-)NCBI
Rnor_5.0768,633,417 - 68,801,189 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039078611   ⟹   XP_038934539
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8762,929,067 - 63,096,982 (-)NCBI
mRatBN7.2761,043,667 - 61,211,545 (-)NCBI
RefSeq Acc Id: XM_039078612   ⟹   XP_038934540
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8762,929,067 - 63,096,982 (-)NCBI
mRatBN7.2761,043,667 - 61,211,545 (-)NCBI
RefSeq Acc Id: XM_039078613   ⟹   XP_038934541
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8762,929,067 - 63,096,983 (-)NCBI
mRatBN7.2761,043,667 - 61,211,547 (-)NCBI
RefSeq Acc Id: XM_039078614   ⟹   XP_038934542
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8762,929,067 - 63,096,983 (-)NCBI
mRatBN7.2761,043,667 - 61,211,547 (-)NCBI
RefSeq Acc Id: XM_039078615   ⟹   XP_038934543
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8762,929,067 - 63,096,983 (-)NCBI
mRatBN7.2761,043,667 - 61,211,547 (-)NCBI
RefSeq Acc Id: XM_039078616   ⟹   XP_038934544
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8762,929,067 - 63,020,967 (-)NCBI
mRatBN7.2761,043,667 - 61,135,533 (-)NCBI
RefSeq Acc Id: XM_039078617   ⟹   XP_038934545
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8762,929,067 - 63,020,967 (-)NCBI
mRatBN7.2761,052,466 - 61,135,520 (-)NCBI
RefSeq Acc Id: XM_063263138   ⟹   XP_063119208
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8762,929,067 - 63,096,982 (-)NCBI
RefSeq Acc Id: XM_063263139   ⟹   XP_063119209
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8762,929,067 - 63,040,699 (-)NCBI
RefSeq Acc Id: XM_063263140   ⟹   XP_063119210
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8762,929,067 - 63,002,987 (-)NCBI
RefSeq Acc Id: XM_063263141   ⟹   XP_063119211
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8762,929,067 - 63,096,982 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001426396 (Get FASTA)   NCBI Sequence Viewer  
  NP_001426397 (Get FASTA)   NCBI Sequence Viewer  
  NP_001426398 (Get FASTA)   NCBI Sequence Viewer  
  NP_001426399 (Get FASTA)   NCBI Sequence Viewer  
  NP_001426400 (Get FASTA)   NCBI Sequence Viewer  
  NP_001426401 (Get FASTA)   NCBI Sequence Viewer  
  NP_001426402 (Get FASTA)   NCBI Sequence Viewer  
  NP_058998 (Get FASTA)   NCBI Sequence Viewer  
  XP_006241494 (Get FASTA)   NCBI Sequence Viewer  
  XP_006241495 (Get FASTA)   NCBI Sequence Viewer  
  XP_006241496 (Get FASTA)   NCBI Sequence Viewer  
  XP_006241497 (Get FASTA)   NCBI Sequence Viewer  
  XP_006241498 (Get FASTA)   NCBI Sequence Viewer  
  XP_038934539 (Get FASTA)   NCBI Sequence Viewer  
  XP_038934540 (Get FASTA)   NCBI Sequence Viewer  
  XP_038934541 (Get FASTA)   NCBI Sequence Viewer  
  XP_038934542 (Get FASTA)   NCBI Sequence Viewer  
  XP_038934543 (Get FASTA)   NCBI Sequence Viewer  
  XP_038934544 (Get FASTA)   NCBI Sequence Viewer  
  XP_038934545 (Get FASTA)   NCBI Sequence Viewer  
  XP_063119208 (Get FASTA)   NCBI Sequence Viewer  
  XP_063119209 (Get FASTA)   NCBI Sequence Viewer  
  XP_063119210 (Get FASTA)   NCBI Sequence Viewer  
  XP_063119211 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAB04023 (Get FASTA)   NCBI Sequence Viewer  
  AAH81701 (Get FASTA)   NCBI Sequence Viewer  
  CAA66074 (Get FASTA)   NCBI Sequence Viewer  
  EDM16524 (Get FASTA)   NCBI Sequence Viewer  
  EDM16525 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000054845
  ENSRNOP00000054845.1
GenBank Protein Q63344 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_058998   ⟸   NM_017302
- UniProtKB: Q63649 (UniProtKB/Swiss-Prot),   Q63344 (UniProtKB/Swiss-Prot),   Q66HS9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006241498   ⟸   XM_006241436
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_006241496   ⟸   XM_006241434
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_006241497   ⟸   XM_006241435
- Peptide Label: isoform X1
- UniProtKB: Q63649 (UniProtKB/Swiss-Prot),   Q63344 (UniProtKB/Swiss-Prot),   Q66HS9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006241495   ⟸   XM_006241433
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_006241494   ⟸   XM_006241432
- Peptide Label: isoform X1
- Sequence:
Ensembl Acc Id: ENSRNOP00000054845   ⟸   ENSRNOT00000058036
Ensembl Acc Id: ENSRNOP00000075465   ⟸   ENSRNOT00000077670
Ensembl Acc Id: ENSRNOP00000073329   ⟸   ENSRNOT00000078014
RefSeq Acc Id: XP_038934543   ⟸   XM_039078615
- Peptide Label: isoform X1
- UniProtKB: Q63649 (UniProtKB/Swiss-Prot),   Q63344 (UniProtKB/Swiss-Prot),   Q66HS9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038934542   ⟸   XM_039078614
- Peptide Label: isoform X1
- UniProtKB: Q63649 (UniProtKB/Swiss-Prot),   Q63344 (UniProtKB/Swiss-Prot),   Q66HS9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038934541   ⟸   XM_039078613
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038934540   ⟸   XM_039078612
- Peptide Label: isoform X1
- UniProtKB: Q63649 (UniProtKB/Swiss-Prot),   Q63344 (UniProtKB/Swiss-Prot),   Q66HS9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038934539   ⟸   XM_039078611
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038934544   ⟸   XM_039078616
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038934545   ⟸   XM_039078617
- Peptide Label: isoform X3
RefSeq Acc Id: XP_063119208   ⟸   XM_063263138
- Peptide Label: isoform X1
- UniProtKB: Q66HS9 (UniProtKB/Swiss-Prot),   Q63649 (UniProtKB/Swiss-Prot),   Q63344 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_063119211   ⟸   XM_063263141
- Peptide Label: isoform X3
RefSeq Acc Id: XP_063119209   ⟸   XM_063263139
- Peptide Label: isoform X1
RefSeq Acc Id: XP_063119210   ⟸   XM_063263140
- Peptide Label: isoform X1
- UniProtKB: Q66HS9 (UniProtKB/Swiss-Prot),   Q63649 (UniProtKB/Swiss-Prot),   Q63344 (UniProtKB/Swiss-Prot)

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q63344-F1-model_v2 AlphaFold Q63344 1-489 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13695239
Promoter ID:EPDNEW_R5764
Type:multiple initiation site
Name:Slc16a7_1
Description:solute carrier family 16 member 7
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0768,549,776 - 68,549,836EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3691 AgrOrtholog
BioCyc Gene G2FUF-33826 BioCyc
Ensembl Genes ENSRNOG00000007839 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000058036 ENTREZGENE
  ENSRNOT00000058036.4 UniProtKB/Swiss-Prot
Gene3D-CATH 1.20.1250.20 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7130138 IMAGE-MGC_LOAD
InterPro MCT UniProtKB/Swiss-Prot
  MFS UniProtKB/Swiss-Prot
  MFS_dom UniProtKB/Swiss-Prot
  MFS_trans_sf UniProtKB/Swiss-Prot
  Proton-linked_MCT UniProtKB/Swiss-Prot
KEGG Report rno:29735 UniProtKB/Swiss-Prot
MGC_CLONE MGC:93092 IMAGE-MGC_LOAD
NCBI Gene 29735 ENTREZGENE
PANTHER MONOCARBOXYLATE TRANSPORTER UniProtKB/Swiss-Prot
  PTHR11360:SF25 UniProtKB/Swiss-Prot
Pfam MFS_1 UniProtKB/Swiss-Prot
PhenoGen Slc16a7 PhenoGen
PROSITE MFS UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000007839 RatGTEx
Superfamily-SCOP SSF103473 UniProtKB/Swiss-Prot
TIGR TC222839
UniProt MOT2_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q63649 ENTREZGENE
  Q66HS9 ENTREZGENE
UniProt Secondary Q63649 UniProtKB/Swiss-Prot
  Q66HS9 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-03-09 Slc16a7  solute carrier family 16 member 7  Slc16a7  solute carrier family 16 (monocarboxylate transporter), member 7  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2013-08-02 Slc16a7  solute carrier family 16 (monocarboxylate transporter), member 7  Slc16a7  solute carrier family 16, member 7 (monocarboxylic acid transporter 2)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-09-19 Slc16a7  solute carrier family 16, member 7 (monocarboxylic acid transporter 2)  Slc16a7  solute carrier family 16 (monocarboxylic acid transporters), member 7  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-09-10 Slc16a7  solute carrier family 16 (monocarboxylic acid transporters), member 7    solute carrier family 16, member 7  Name updated 1299863 APPROVED
2002-06-10 Slc16a7  solute carrier family 16, member 7      Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in neurons and some astrocyte populations 734496